CN106343567A - Noni oral liquid and preparing method thereof - Google Patents

Noni oral liquid and preparing method thereof Download PDF

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Publication number
CN106343567A
CN106343567A CN201610764286.XA CN201610764286A CN106343567A CN 106343567 A CN106343567 A CN 106343567A CN 201610764286 A CN201610764286 A CN 201610764286A CN 106343567 A CN106343567 A CN 106343567A
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China
Prior art keywords
radix
noni fruit
fructus
oral liquid
noni
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CN201610764286.XA
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Inventor
郑超
纪明慧
马龙
秦伟
陈光英
孙振范
蒋应良
那日松
郑彩娟
宋小平
韩长日
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Hainan Normal University
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Hainan Normal University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K2236/30—Extraction of the material
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    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a noni oral liquid and preparing method, wherein, the oral liquid consisting of the followings by weight: crude drug: noni 3 : 3 - 12 : 3, the crude drug comprising the following components: chrysanthemum budz, hawthorn fruit, liquorice root, peppermint, medlar, red dates, longans, dwarf lilyturf, boat-fruited sterculia, herbal tea, pericarpium citri reticulatae, angelica dahurica, ginseng, codonopsis, rhizoma chuanxiong, astragalus, rose, red ginseng, yellow skin dry, jasmine. Frequently taking oral liquid could increase immune system, improve fatigue, reduce blood viscosity, resist thrombus, subsidiarily treat the disease of heart head blood-vessel, lower blood pressure and blood fat, alleviate diabetes and other symptoms. The preparing method is mixing noni frementation broth and water extract stoste of various medicinal materials, the noni frementation broth could help Chinese herbal medicine playing efficacy and promote cells to absorb, playing the health care efficacy of enhancing immunity and resist fatigue.

Description

A kind of Noni fruit oral liquid and preparation method thereof
Technical field
The present invention relates to technical field of food healthcare, more particularly, to a kind of Noni fruit oral liquid and preparation method thereof.
Background technology
Noni (noni), also known as Morinda Citifolia, Morinda citrifolia Linn., Solanum pseudo-capsicumvar diflorum (Vell.)Bitter etc., genus rubia section Morinda plant.This plant master It is distributed in the South Sea Islands small island, such as Philippine, Australia etc..Existing China is mainly distributed on the heat such as Hainan, the Xisha Islands Band area, has been carried out planting on a large scale.Noni has stronger functional character, and root, stem, leaf, flower and fruit all can be used as medicine. Root can obtain yellow or the dyestuff of redness is used for contaminating clothes, and edible fruit is used, as food stage health product.South Pacific Ocean island Noni is had more than 2000 year by Polynesian as food, medicine.Noni, as a kind of world medicinal plants new lover, draws Food, the extensive concern of medicine researcher are played, therefrom isolation identification out about 200 compounds, mainly comprise anthraquinone, flavone, perfume (or spice) The composition of the compositions such as legumin, glucosides, triterpeness, its Middle East scopola booth, rutin, maloic acid, tannin card are considered as in noni Effective active composition.In addition noni is peaceful rich in unsaturated fatty acid, vitamin, mineral, antioxidant, rare element and celo Peaceful invertase of former, celo etc..At present the bioactivity research of noni is focused primarily upon with antibacterial, prophylaxis of tumours, removes free radical And antioxidation and other functional characteristics.Due to the unique functional characteristic of noni, it has been one of global best-selling health-oriented products. Noni, because of with health role and multiple nutrient substance, therefore can be made fruit juice or make oral liquid, mix with other extracts Close, form the health promoting product with peculiar flavour.But due to noni stock solution bitter taste itself, still can be residual in oral liquid and fruit juice Stay the distinctive bad smell of noni, the following process that this abnormal smells from the patient has had a strong impact on raw material is used.
Content of the invention
In view of this, the invention provides a kind of Noni fruit oral liquid and preparation method thereof, described Noni fruit oral liquid is in fact The effect having showed enhancing immunity and having improved fatigue, and additionally provide the preparation method of described oral liquid.
The technological means that the present invention adopts are as follows: a kind of Noni fruit oral liquid, including the component of following weight proportion:
Crude drug: Noni fruit is 3:3～12:3, described crude drug includes following components: tire chrysanthemum, Fructus Crataegi, Radix Glycyrrhizae, Herba Menthae, Fructus Lycii, Fructus Jujubae, Arillus Longan, Radix Ophiopogonis, Semen Sterculiae Lychnophorae, Fructus Momordicae, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae, Korean Ginseng, Radix Codonopsis, Rhizoma Chuanxiong, the Radix Astragali, Flos Rosae Rugosae, Radix Ginseng Rubra, Clausena lansium (Lour.) Skeels do, Flos Jasmini Sambac.
Preferably, described crude drug includes the component of following weight proportion: tire chrysanthemum: Fructus Crataegi is 1:1～4:3, Fructus Crataegi: Radix Glycyrrhizae For 2:1～5:2, Herba Menthae: Fructus Lycii is 1:1～3:2, Fructus Lycii: Fructus Jujubae is 5:4～2:1, Fructus Jujubae: Arillus Longan is 1:1～3:2, Radix Ophiopogonis: Semen Sterculiae Lychnophorae is 1:1～2:1, Semen Sterculiae Lychnophorae: Fructus Momordicae is 4:3～3:2, Fructus Momordicae: Pericarpium Citri Reticulatae is 1:1～5:2, the Radix Angelicae Dahuricae: Korean Ginseng is 1:1～3:2, Korean Ginseng: Radix Codonopsis is 5:3～2:1, Rhizoma Chuanxiong: the Radix Astragali is 4:3～2:1, the Radix Astragali: Flos Rosae Rugosae is 3:2～2:1, Flos Rosae Rugosae: Radix Ginseng Rubra is 4:3～3:2, and Clausena lansium (Lour.) Skeels do: Flos Jasmini Sambac is 1:1～2:1.
Preferably, described crude drug also includes Flos Lonicerae.
Preferably, described crude drug includes the component of following weight proportion: tire chrysanthemum: Fructus Crataegi is 3:2～5:2, Radix Glycyrrhizae: Herba Menthae For 1:1～4:3, Flos Lonicerae: Fructus Lycii is 4:3～3:2, Flos Lonicerae: Fructus Jujubae is 3:2～2:1, Fructus Jujubae: Arillus Longan is 1:1～5:3, wheat Winter: Semen Sterculiae Lychnophorae is 5:4～2:1, Semen Sterculiae Lychnophorae: Fructus Momordicae is 4:3～3:2, Pericarpium Citri Reticulatae: the Radix Angelicae Dahuricae is 1:1～3:2, Korean Ginseng: Radix Codonopsis is 3:2～5:2, Radix Codonopsis: Rhizoma Chuanxiong is 1:1～3:2, Rhizoma Chuanxiong: the Radix Astragali is 5:4～3:2, Flos Rosae Rugosae: Radix Ginseng Rubra is 4:3～2:1, Radix Ginseng Rubra: yellow Pi Gan is 1:1～5:4, and Clausena lansium (Lour.) Skeels do: Flos Jasmini Sambac is 3:2～5:2.
Present invention additionally comprises a kind of preparation method of Noni fruit oral liquid, comprise the following steps:
(1) Noni fruit cleans, inoculates, entering tank, fermentation, obtains Noni fruit fermentation liquid；
(2) take crude drug, add pure water, boil, the water extract stock solution that cooled and filtered obtains；
(3) water extract stock solution is mixed with Noni fruit fermentation liquid, after adjusting ph value 5～7, sterilization filling.
Preferably, calculate by mass percentage, described step (1) inoculates 3% bacillus bifiduss and 2% breast for putting into activation In acidfast bacilli mixed fermentation strain liquid, and the content of mixed fermentation strain liquid is the 5% of Noni fruit gross weight.
Preferably, described step (1) ferment be 28 DEG C～32 DEG C of temperature, ph value 5.8～7.2, pressure 0.05mpa～ Under 0.09mpa, ferment 90 days～120 days.
Preferably, 2～8:2 mixes water extract stock solution in proportion with Noni fruit fermentation liquid.
Using a kind of Noni fruit oral liquid provided by the present invention and preparation method thereof, wherein Noni fruit oral liquid, mixing The Chinese crude drug that substantial amounts of daily life is commonly used, Noni fruit fermentation liquid can help Chinese crude drug to play drug effect, promotes cell to absorb Effect.Wherein based on Noni fruit fermentation liquid, Noni fruit has repair cell, removes interior free yl and alluvial toxin, stops Cellular oxidation, and strengthen cell, the effect of delaying cell aging；Secondly, Radix Glycyrrhizae has the activity of suppression tryrosinase, and has The functions such as antiinflammatory, defying age, uvioresistant；Again, the Radix Astragali passes through to suppress b16 melanocyte propagation to reach whitening effect；? Afterwards, Fructus Jujubae, Arillus Longan have lively atmosphere of enriching blood, make and having rosy cheeks.Other Chinese crude drugs such as scalding, Radix Ginseng, Radix Angelicae Sinensis also may select from into Row is compounding.And in Fructus Crataegi, vitamin content is high and flavone compound is 20 times of common fruit, has blood circulation promoting and blood stasis dispelling, treatment Suffer from diarrhoea, reduce blood pressure and cholesterol, vessel softening and diuresis, calm effect.Flos Lonicerae plays pathogenic microorganism, antiinflammatory solution Poison, has reached unexpected effect in cosmetic slimming, health care.Tire chrysanthemum can the effect such as antioxidation, antitumor, blood sugar lowering.Water Extract farthest remains the important component in raw material, substantially improves the bitter taste of Noni fruit stock solution so as to noni Fruit oral liquid reaches the effects such as enhance immunity, resisting fatigue, appetizing, blood fat reducing, antitumor, aesthetic health care.
Specific embodiment
Hereinafter the principle and feature of the present invention is described, example is served only for explaining the present invention, is not intended to limit Determine the scope of the present invention.
Embodiment 1
A kind of Noni fruit oral liquid, including the component of following weight proportion: crude drug: Noni fruit is 3:3, described crude drug Component including following weight proportion: tire chrysanthemum: Fructus Crataegi is 1:1, Fructus Crataegi: Radix Glycyrrhizae is 2:1, Herba Menthae: Fructus Lycii is 1:1, Fructus Lycii: Fructus Jujubae For 5:4, Fructus Jujubae: Arillus Longan is 1:1, Radix Ophiopogonis: Semen Sterculiae Lychnophorae is 1:1, Semen Sterculiae Lychnophorae: Fructus Momordicae is 4:3, Fructus Momordicae: Pericarpium Citri Reticulatae is 1:1, in vain The root of Dahurian angelica: Korean Ginseng is 1:1, Korean Ginseng: Radix Codonopsis is 5:3, Rhizoma Chuanxiong: the Radix Astragali is 4:3, the Radix Astragali: Flos Rosae Rugosae is 3:2, Flos Rosae Rugosae: Radix Ginseng Rubra is 4:3, Clausena lansium (Lour.) Skeels do: Flos Jasmini Sambac is 1:1.
Wherein, crude drug 50g, Noni fruit 50g are taken, described crude drug includes the component of following weight: tire chrysanthemum 10g, Fructus Crataegi 10g, Radix Glycyrrhizae 5g, Herba Menthae 5g, Fructus Lycii 5g, Fructus Jujubae 4g, Arillus Longan 4g, Radix Ophiopogonis 8g, Semen Sterculiae Lychnophorae 8g, Fructus Momordicae 6g, Pericarpium Citri Reticulatae 6g, the Radix Angelicae Dahuricae 5g, Korean Ginseng 5g, Radix Codonopsis 3g, Rhizoma Chuanxiong 4g, Radix Astragali 3g, Flos Rosae Rugosae 2g, Radix Ginseng Rubra 1.5g, Clausena lansium (Lour.) Skeels do 3g, Flos Jasmini Sambac 3g.
A kind of preparation method of Noni fruit oral liquid, comprises the following steps:
(1) Noni fruit cleaning, the Noni fruit draining is put into inoculation in the mixed fermentation strain liquid of activation, wherein, containing 3% Bifidus bacilluss and 2% lactobacilluss, and the interpolation content of mixed fermentation strain liquid be Noni fruit gross weight 5%, in 28 DEG C, Ph value for soaking 2 minutes under conditions of 5.8, after proceed in fermentation tank, remaining fermentation fluid strain is uniformly spilled in fermentation tank, Close valve, temperature-control pressure-control is answered in fermentation, and temperature is 25 DEG C, pressure is 0.05mpa, fermentation time is 90 days, obtain Noni fruit fermentation Liquid.
(2) take crude drug, add 1000ml pure water, boil 20min, the water extract that cooled and filtered obtains 600ml is former Liquid.
(3) water extract stock solution is mixed with Noni fruit fermentation liquid 2:2, after adjusting ph value 5～7, gone out in sterilizer Bacterium is processed, 95 ± 2 DEG C of temperature, and 5～10 seconds time carried out sterilization treatment, fill after sterilizing.
Embodiment 2
A kind of Noni fruit oral liquid, including the component of following weight proportion: crude drug: Noni fruit is 9:3, described crude drug Component including following weight proportion: tire chrysanthemum: Fructus Crataegi is 4:3, Fructus Crataegi: Radix Glycyrrhizae is 5:2, Herba Menthae: Fructus Lycii is 3:2, Fructus Lycii: Fructus Jujubae For 2:1, Fructus Jujubae: Arillus Longan is 3:2, Radix Ophiopogonis: Semen Sterculiae Lychnophorae is 2:1, Semen Sterculiae Lychnophorae: Fructus Momordicae is 3:2, Fructus Momordicae: Pericarpium Citri Reticulatae is 5:2, in vain The root of Dahurian angelica: Korean Ginseng is 3:2, Korean Ginseng: Radix Codonopsis is 2:1, Rhizoma Chuanxiong: the Radix Astragali is 2:1, the Radix Astragali: Flos Rosae Rugosae is 2:1, Flos Rosae Rugosae: Radix Ginseng Rubra is 3:2, Clausena lansium (Lour.) Skeels do: Flos Jasmini Sambac is 2:1.
Wherein, crude drug 60g, Noni fruit 20g are taken, described crude drug includes the component of following weight proportion: tire chrysanthemum 12g, Fructus Crataegi 9g, Radix Glycyrrhizae 3.6g, Herba Menthae 18g, Fructus Lycii 12g, Fructus Jujubae 6g, Arillus Longan 4g, Radix Ophiopogonis 24g, Semen Sterculiae Lychnophorae 12g, Fructus Momordicae 8g, Pericarpium Citri Reticulatae 3.2g, Radix Angelicae Dahuricae 12g, Korean Ginseng 8g, Radix Codonopsis 4g, Rhizoma Chuanxiong 48g, Radix Astragali 24g, Flos Rosae Rugosae 12g, Radix Ginseng Rubra 8g, Clausena lansium (Lour.) Skeels do 20g, Flos Jasmini Sambac 10g.
A kind of preparation method of Noni fruit oral liquid, comprises the following steps:
(1) Noni fruit cleaning, the Noni fruit draining is put into inoculation in the mixed fermentation strain liquid of activation, wherein, containing 3% Bifidus bacilluss and 2% lactobacilluss, and the interpolation content of mixed fermentation strain liquid be Noni fruit gross weight 5%, in 32 DEG C, Ph value for soaking 3 minutes under conditions of 7.2, after proceed in fermentation tank, remaining fermentation fluid strain is uniformly spilled in fermentation tank, Close valve, temperature-control pressure-control is answered in fermentation, and temperature is 35 DEG C, pressure is 0.09mpa, fermentation time is 120 days, obtains Noni fruit and sends out Zymotic fluid.
(2) take crude drug, add 1000ml pure water, boil 30min, the water extract that cooled and filtered obtains 600ml is former Liquid.
(3) by water extract stock solution, 3:2 mixes in proportion with Noni fruit fermentation liquid, after adjusting ph value 5～7, in sterilizer Carry out sterilization treatment, 95 ± 2 DEG C of temperature, 5～10 seconds time carried out sterilization treatment, fill after sterilizing.
Embodiment 3
A kind of Noni fruit oral liquid, including the component of following weight proportion: crude drug: Noni fruit is 5:3, described crude drug Component including following weight proportion: tire chrysanthemum: Fructus Crataegi is 3:2, Radix Glycyrrhizae: Herba Menthae is 1:1, Flos Lonicerae: Fructus Lycii is 4:3, Flos Lonicerae: Fructus Jujubae is 3:2, Fructus Jujubae: Arillus Longan is 1:1, Radix Ophiopogonis: Semen Sterculiae Lychnophorae is 5:4, Semen Sterculiae Lychnophorae: Fructus Momordicae is 4:3, Pericarpium Citri Reticulatae: the Radix Angelicae Dahuricae is 1:1, Korean Ginseng: Radix Codonopsis is 3:2, Radix Codonopsis: Rhizoma Chuanxiong is 1:1, Rhizoma Chuanxiong: the Radix Astragali is 5:4, Flos Rosae Rugosae: Radix Ginseng Rubra is 4:3, Radix Ginseng Rubra: Clausena lansium (Lour.) Skeels do as 1: 1, Clausena lansium (Lour.) Skeels do: Flos Jasmini Sambac is 3:2.
Wherein, crude drug 50g, Noni fruit 30g are taken, described crude drug includes the component of following weight: tire chrysanthemum 9g, Fructus Crataegi 4g, Radix Glycyrrhizae 10g, Herba Menthae 10g, Flos Lonicerae 12g, Fructus Lycii 9g, Fructus Jujubae 8g, Arillus Longan 8g, Radix Ophiopogonis, 5g, Semen Sterculiae Lychnophorae 4g, Fructus Momordicae 3g, old Skin 6g, Radix Angelicae Dahuricae 6g, Korean Ginseng 9g, Radix Codonopsis 6g, Rhizoma Chuanxiong 6g, Radix Astragali 4.8g, Flos Rosae Rugosae 8g, Radix Ginseng Rubra 6g, Clausena lansium (Lour.) Skeels do 6g, Flos Jasmini Sambac 4g.
A kind of preparation method of Noni fruit oral liquid, comprises the following steps:
(1) Noni fruit cleaning, the Noni fruit draining is put into inoculation in the mixed fermentation strain liquid of activation, wherein, containing 3% Bifidus bacilluss and 2% lactobacilluss, and the interpolation content of mixed fermentation strain liquid be Noni fruit gross weight 5%, in 30 DEG C, Ph value for soaking 5 minutes under conditions of 6.5, after proceed in fermentation tank, remaining fermentation fluid strain is uniformly spilled in fermentation tank, Close valve, temperature-control pressure-control is answered in fermentation, and temperature is 30 DEG C, pressure is 0.07mpa, fermentation time is 100 days, obtain Noni fruit fermentation Liquid.
(2) take crude drug, add 1000ml pure water, boil 25min, the water extract that cooled and filtered obtains 600ml is former Liquid.
(3) by water extract stock solution, 7:2 mixes in proportion with Noni fruit fermentation liquid, after adjusting ph value 5～7, in sterilizer Carry out sterilization treatment, 95 ± 2 DEG C of temperature, 5～10 seconds time carried out sterilization treatment, fill after sterilizing.
Embodiment 4
A kind of Noni fruit oral liquid, including the component of following weight proportion: crude drug: Noni fruit is 12:3, described raw material Medicine includes the component of following weight proportion: tire chrysanthemum: Fructus Crataegi is 5:2, Radix Glycyrrhizae: Herba Menthae is 4:3, Flos Lonicerae: Fructus Lycii is 3:2, gold silver Flower: Fructus Jujubae is 2:1, Fructus Jujubae: Arillus Longan is 5:3, Radix Ophiopogonis: Semen Sterculiae Lychnophorae is 2:1, Semen Sterculiae Lychnophorae: Fructus Momordicae is 3:2, Pericarpium Citri Reticulatae: the Radix Angelicae Dahuricae is 3: 2, Korean Ginseng: Radix Codonopsis is 5:2, Radix Codonopsis: Rhizoma Chuanxiong is 3:2, Rhizoma Chuanxiong: the Radix Astragali is 3:2, Flos Rosae Rugosae: Radix Ginseng Rubra is 2:1, Radix Ginseng Rubra: Clausena lansium (Lour.) Skeels are dry to be 5:4, Clausena lansium (Lour.) Skeels do: Flos Jasmini Sambac is 5:2.
Wherein, crude drug 120g, Noni fruit 30g are taken, described crude drug includes the component of following weight: tire chrysanthemum 10g, Fructus Crataegi 4g, Radix Glycyrrhizae 40g, Herba Menthae 30g, Flos Lonicerae 30g, Fructus Lycii 20g, Fructus Jujubae 15g, Arillus Longan 9g, Radix Ophiopogonis 18g, Semen Sterculiae Lychnophorae 9g, Fructus Momordicae 6g, Pericarpium Citri Reticulatae 9g, Radix Angelicae Dahuricae 6g, Korean Ginseng 45g, Radix Codonopsis 18g, Rhizoma Chuanxiong 12g, Radix Astragali 8g, Flos Rosae Rugosae 50g, Radix Ginseng Rubra 25g, Clausena lansium (Lour.) Skeels do 20g, Flos Jasmini Sambac 8g.
A kind of preparation method of Noni fruit oral liquid, comprises the following steps:
(1) Noni fruit cleaning, the Noni fruit draining is put into inoculation in the mixed fermentation strain liquid of activation, wherein, containing 3% Bifidus bacilluss and 2% lactobacilluss, and the interpolation content of mixed fermentation strain liquid be Noni fruit gross weight 5%, in 28 DEG C, Ph value for soaking 2 minutes under conditions of 5.8, after proceed in fermentation tank, remaining fermentation fluid strain is uniformly spilled in fermentation tank, Close valve, temperature-control pressure-control is answered in fermentation, and temperature is 25 DEG C, pressure is 0.05mpa, fermentation time is 90 days, obtain Noni fruit fermentation Liquid.
(2) take crude drug, add 1000ml pure water, boil 20min, the water extract that cooled and filtered obtains 600ml is former Liquid.
(3) by water extract stock solution, 8:2 mixes in proportion with Noni fruit fermentation liquid, after adjusting ph value 5～7, in sterilizer Carry out sterilization treatment, 95 ± 2 DEG C of temperature, 5～10 seconds time carried out sterilization treatment, fill after sterilizing.
Wherein: bacillus bifiduss are one of most important physiological antibacterials in humans and animals intestinal, have maintenance ecological balance, Many physiological functions such as biological antagonist, immunomodulating and nutrition.Lactobacillus genus lactic acid Bacteriaceae, because sugar fermentation produces A large amount of lactic acid and name, it exists extensively, acidophilia, and existence optimum ph is 5.5～6.0, safeguards health and adjusts immunity The effect of function is widely recognized as.Bifidus bacilluss and lactobacilluss are adopted to send out as compound in Noni fruit fermentation liquid preparation process Yeast-like fungi kind, can produce cooperative effect, more can give full play to the respective advantage of this strain, improve fermentation efficiency, mouthfeel is more preferably.Promise Beautiful fruit fermentation liquid preparation process, the interpolation content of component, reaction temperature, the control of ph value, pressure and time are impact noni The key factor of fruit fermentation quality.
The Noni fruit oral liquid that this preparation method produces, additive-free preservative free, low temperature preparation, step is simple, maximum The extraction of limit and remain Noni fruit and the drug effect of Chinese crude drug, not only easily absorbs, steady quality, and substantially improves promise The bitter taste of beautiful fruit stock solution, mouthfeel is fabulous.
The Noni fruit Liquid detection result of the embodiment of the present invention 1～4 preparation is as follows:
In order to verify beneficial effects of the present invention, the present invention carries out tests below:
First, the test method of enhancing immunity function and experimental result are as follows:
1st, test method
Take mice 90, single sex, be randomly divided into 6 groups, negative (distilled water) matched group, the positive (ANSHEN BUNAO YE) are right According to group, Noni fruit oral liquid experimental group 1 (embodiment 1), experimental group 2 (embodiment 2), experimental group 3 (embodiment 3), experimental group 4 (embodiment 4).
Negative (distilled water) matched group: in experiment process, any process is not made in normal raising.
Positive (ANSHEN BUNAO YE) matched group: add the ANSHEN BUNAO YE of half in the drinking water raised, one month even After continuous raising, extract mouse blood to be checked.Wherein ANSHEN BUNAO YE is commercially available ANSHEN BUNAO YE.
Experimental group 1,2,3,4: add the Noni fruit oral liquid of half, a continuous raising in month in the drinking water raised Afterwards, extract each group mouse blood to be detected, with flow cytomery t cell subsets content.Specifically include that t-helper drenches Bar cell (cd4+), cytotoxic T lymphocyte (cd8+), cd4+/cd8+.
2nd, experimental result
Result shows that the cd8+ of experimental group 1～4 dramatically increases.The cd4+ cell proportion of experimental group 1～4 also increases simultaneously. Comparatively speaking, experimental group 1 and experimental group 4 effect are preferable.Cd4+/cd8+ (%) is in normal scope.
2nd, the present invention has also done the experiment of resisting fatigue, and its experimental technique and result are as follows:
1st, experimental animal: 210 healthy and strong male white mouses, body weight 25g.There is provided by Guangzhou animal experimental center.Experiment periods Between all animals give cleaning grade Mus pellet and aquesterilisa freely eats.
2nd, test method and result
Dosage choice: animal used is all respectively divided into 14 groups by body weight white mice, as negative (distilled water) matched group, sun Property (ANSHEN BUNAO YE) matched group, Noni fruit oral liquid experimental group 1 (embodiment 1 low dosage), experimental group 2 (agent in embodiment 1 Amount), experimental group 3 (embodiment 1 high dose), experimental group 4 (embodiment 2 low dosage), experimental group 5 (embodiment 2 middle dosage), experiment Group 6 (embodiment 2 high doses), experimental group 7 (embodiment 3 low dosage), experimental group 8 (embodiment 3 middle dosage), experimental group 9 (are implemented Example 3 high dose), experimental group 10 (embodiment 4 low dosage), experimental group 11 (embodiment 4 middle dosage), (embodiment 4 is high for experimental group 12 Dosage), every group 15.According to white mice body weight, mice continuous gavage 30d, experimental group gives each group Noni fruit oral liquid, cloudy Property matched group give to wait capacity solvent distilled water, positive controls (ANSHEN BUNAO YE) give 0.2ml/10g.Wherein low dosage refers to 0.2ml/10g, middle dosage refers to 0.4ml/10g, and high dose refers to 0.6ml/10g.During test, mice freely ingests and drinks water, every 2d weighs a body weight, adjusts gavage amount according to body weight.
Swimming with a load attached to the body is tested: after administration 30d, after last gavage 30min, puts white mice in glass swimming cylinder went swimming, Mus The sheet lead of root of the tail portion load body weight 5%, record mice starts to be unable to floatation time to submerged 8s from swimming, and the power of being recorded as exhausts Time (min).Swimming endurance experimental result see table:
Conclusion (of pressure testing): compare * p ＜ 0.05, * * p the ＜ 0.01, (experiment of the middle and high dosage group of the present composition with matched group Group 3,6,9,12) can significantly extend mice swimming time, there is pole significant (p ＜ 0.01), show Noni fruit of the present invention The compositionss of oral liquid have antifatigue effect.From table, each dosage group mice swimming time all extends than matched group, its In, there were significant differences compared with negative control class value for middle and high dosage group, and middle and high dosage group is also had compared with positive control class value Significant difference, between basic, normal, high dosage group, difference is not notable, when showing that Noni fruit oral liquid has prolongation mice burden swimming Between act on.In embodiment, 1 and 4 effects are preferable.This sample Loaned swimming test is positive, evaluates mark according to function of health food Standard, this sample has the effect of alleviating physical fatigue.Noni fruit oral liquid shows good antifatigue effect, thus is a kind of There is very much the natural anti-fatigue health-product containing of potentiality to be exploited.
3rd, the present invention has a following clinical efficacy:
1.1 are suitable for crowd
Teenager, 50, immunologic hypofunction, easily catch a cold, averagely monthly 2 times and more than, be off one's feed.
Adult, 50, melanin is many, and speckle acne print is many, poor sleeping quality.
Old people, suffers from multiple chronic diseases, hypertension and osteoporosises by 50.
1.2 method of administration
The oral embodiment of the present invention 1,4,2 times a day, 5 grams every time, continuously takes 3 months.
1.3 observation index
Carry out routine examination, and observed and recorded: heating, sniffle, pharyngeal symptom, body temperature, picture of the tongue pulse condition, skin smooth The feature such as degree and immunity.
1.4 criterion
1.4.1 efficacy of immunity criterion
Effective: body immunity significantly improves, teenager times of common cold one month is once even without adult occurs without Poor sleeping quality, blood pressure of old people is reduced to normal range and keeps stable, occurs without osteoporosises phenomenon.
Effective: body immunity improves, and once poor sleeping quality number of times to teenager times of common cold in adult within one month Few, blood pressure of old people is slightly higher and keeps stable,.
Invalid: teenager, adult and old people's symptom are not improved.
1.4.2 skin improves criterion
Effective: skin is clearly better, acne print and speckle no longer occur.
Effective: cutaneous roughness weakens.
Invalid: pachylosiies do not improve.
1.5 therapeutic evaluation
1.5.1 immunity therapeutic evaluation
Table 1 immunity therapeutic evaluation
Number of cases Effective Effectively Invalid Total effective rate %
Embodiment 1 50 32 11 7 86
Embodiment 4 50 34 8 8 84
1.5.2 skin improves therapeutic evaluation
Table 2 skin improves therapeutic evaluation
Number of cases Effective Effectively Invalid Total effective rate %
Embodiment 1 50 29 14 7 86
Embodiment 4 50 31 14 5 90
Can be drawn by table 1, table 2, embodiment 1, the total effective rate of 4 enhance immunities are respectively 86%, 84%, and skin changes Kind total effective rate is respectively 86%, 90%.Show that the present invention has enhance immunity and improves skin coarseness, there is beauty treatment And other effects.
4th, other clinical efficacies:
1st, method of administration:
Drink in half an hour before meals (on an empty stomach), drink same amount daily, cooperation substantial amounts of drinking-water effect is more preferable.Oral liquid General one bottle after meal (25ml/ bottle) sooner or later (can increment according to required health-care effect).Noni fruit oral liquid is typically drunk three months More than.
2nd, the healing crisis of Noni fruit oral liquid are drunk:
Comedo: the initial stage can somewhat increase, the later stage can disappear quickly.
Suffer from indiestion: after taking, digestion is strengthened with functions of expelling toxin, and appetizing is aid digestion, and appetite improves.
Black speck, chloasma: the initial stage takes no significant change, speckle can be gradually thin out afterwards, can eliminate melanin, speckle dispelling Disappear acne print, improve the health care of sleep, lose weight, whitening and skin-protecting.
Hypertension: after taking, can blood pressure lowering and blood fat reducing etc..
Diabetes: start blood glucose and understand some increases, can alleviate later.
Body constitution is poor: can increase body self-resistance, promote the growth of skeleton.
Gout: general powerlessness or ache, just disappear after a few days, can strengthen trick motility, prevent osteoporosises, Suppression arthritis, promotion cell regeneration.
Fat-reducing: long-term taking promotes reduction blood fat, reaches the effect of fat-reducing
Blood circulation promoting and blood stasis dispelling: contribute to contacting local congestion state, have auxiliary curative effect to traumatic injury.
Insomnia: can be used for the insomnia caused by insufficiency of the spleen damage of the heart etc., tranquilization and refreshment.
Long-term taking will feel the change that body occurs, and bodily tissue organ strengthens immunologic function, energetic, skin Skin is ruddy flexible, provides various nutrient substance for human body.
In sum, using a kind of Noni fruit oral liquid provided by the present invention and preparation method thereof, Noni fruit is fermented Afterwards, the materials such as the protein being easily absorbed by the body, saccharide are resolved into, simultaneously the also presence containing materials such as solubility calcium, ferrum, will Noni fruit fermentation liquid is mixed with the water extract of multiple medical material mixed rehousings, and Noni fruit itself contains various nutrient elements, and The water extract disposing is all common health product in life, be used in mixed way can play enhancing immunity, improve tired, no any Side effect, supplements the nutritional labeling of needed by human body, is suitable for various crowd demand's scopes.By instructions of taking, can strengthen from body Matter, promotes the absorption of the materials such as skeletal calcium.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention Within god and principle, any modification, equivalent substitution and improvement done etc., should be included within the scope of protection of the invention.

Claims (8)

1. a kind of Noni fruit oral liquid is it is characterised in that include the component of following weight proportion:
Crude drug: Noni fruit is 3:3～12:3, described crude drug includes following components: tire chrysanthemum, Fructus Crataegi, Radix Glycyrrhizae, Herba Menthae, Fructus Lycii, Fructus Jujubae, Arillus Longan, Radix Ophiopogonis, Semen Sterculiae Lychnophorae, Fructus Momordicae, Pericarpium Citri Reticulatae, the Radix Angelicae Dahuricae, Korean Ginseng, Radix Codonopsis, Rhizoma Chuanxiong, the Radix Astragali, Flos Rosae Rugosae, Radix Ginseng Rubra, Clausena lansium (Lour.) Skeels Dry, Flos Jasmini Sambac.
2. a kind of Noni fruit oral liquid according to claim 1 is it is characterised in that described crude drug includes following weight joins The component of ratio: tire chrysanthemum: Fructus Crataegi is 1:1～4:3, Fructus Crataegi: Radix Glycyrrhizae is 2:1～5:2, Herba Menthae: Fructus Lycii is 1:1～3:2, Fructus Lycii: red Fructus Jujubae is 5:4～2:1, Fructus Jujubae: Arillus Longan is 1:1～3:2, Radix Ophiopogonis: Semen Sterculiae Lychnophorae is 1:1～2:1, Semen Sterculiae Lychnophorae: Fructus Momordicae is 4:3～3: 2, Fructus Momordicae: Pericarpium Citri Reticulatae is 1:1～5:2, the Radix Angelicae Dahuricae: Korean Ginseng is 1:1～3:2, Korean Ginseng: Radix Codonopsis is 5:3～2:1, Rhizoma Chuanxiong: the Radix Astragali For 4:3～2:1, the Radix Astragali: Flos Rosae Rugosae is 3:2～2:1, Flos Rosae Rugosae: Radix Ginseng Rubra is 4:3～3:2, Clausena lansium (Lour.) Skeels do: Flos Jasmini Sambac is 1:1～2:1.
3. a kind of Noni fruit oral liquid according to claim 1 is it is characterised in that described crude drug also includes Flos Lonicerae.
4. a kind of Noni fruit oral liquid according to claim 3 is it is characterised in that described crude drug includes following weight joins The component of ratio: tire chrysanthemum: Fructus Crataegi is 3:2～5:2, Radix Glycyrrhizae: Herba Menthae is 1:1～4:3, Flos Lonicerae: Fructus Lycii is 4:3～3:2, gold silver Flower: Fructus Jujubae is 3:2～2:1, Fructus Jujubae: Arillus Longan is 1:1～5:3, Radix Ophiopogonis: Semen Sterculiae Lychnophorae is 5:4～2:1, Semen Sterculiae Lychnophorae: Fructus Momordicae is 4: 3～3:2, Pericarpium Citri Reticulatae: the Radix Angelicae Dahuricae is 1:1～3:2, Korean Ginseng: Radix Codonopsis is 3:2～5:2, Radix Codonopsis: Rhizoma Chuanxiong is 1:1～3:2, Rhizoma Chuanxiong: yellow Stilbene is 5:4～3:2, Flos Rosae Rugosae: Radix Ginseng Rubra is 4:3～2:1, Radix Ginseng Rubra: Clausena lansium (Lour.) Skeels do as 1:1～5:4, and Clausena lansium (Lour.) Skeels do: Flos Jasmini Sambac is 3:2～5: 2.
5. a kind of preparation method of the Noni fruit oral liquid according to any one of Claims 1 to 4 is it is characterised in that include Following steps:
(1) Noni fruit cleans, inoculates, entering tank, fermentation, obtains Noni fruit fermentation liquid；
(2) take crude drug, add pure water, boil, the water extract stock solution that cooled and filtered obtains；
(3) water extract stock solution is mixed with Noni fruit fermentation liquid, after adjusting ph value 5～7, sterilization filling.
6. a kind of preparation method of Noni fruit oral liquid according to claim 5 is it is characterised in that by mass percentage Calculate, described step (1) is inoculated in 3% bacillus bifiduss and 2% lactobacilluss mixed fermentation strain liquid for putting into activation, and mix The content of fermented bacterium liquid is the 5% of Noni fruit gross weight.
7. a kind of preparation method of Noni fruit oral liquid according to claim 5 is it is characterised in that described step (1) is sent out Ferment is under 28 DEG C～32 DEG C of temperature, ph value 5.8～7.2, pressure 0.05mpa～0.09mpa, ferments 90 days～120 days.
8. a kind of Noni fruit oral liquid according to claim 5 preparation method it is characterised in that water extract stock solution with 2～8:2 the mixing in proportion of Noni fruit fermentation liquid.
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CN108271975A (en) * 2018-01-18 2018-07-13 深圳中科荣耀生物科技有限公司 A kind of antifatigue Noni fruit zymotic fluid composite fruit juice and preparation method thereof
CN108851064A (en) * 2018-08-24 2018-11-23 唐山市奥源生物科技有限公司 A kind of Chinese medicine and health food of fermentation
CN109527496A (en) * 2018-11-30 2019-03-29 海南职业技术学院 A kind of preparation method of food composite nourishing energizing agent
CN109874897A (en) * 2019-04-03 2019-06-14 海南酵老师生物科技有限公司 A kind of Noni fruit fermentation fruit tea and preparation method thereof
CN113243530A (en) * 2021-05-25 2021-08-13 海南华美益实业有限公司 Noni powder electuary and preparation method thereof

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Application publication date: 20170125