CN101244154B - Pharmaceutical combination for bearing and rearing better children, preventing birth defect and improving anamnesis - Google Patents
Pharmaceutical combination for bearing and rearing better children, preventing birth defect and improving anamnesis Download PDFInfo
- Publication number
- CN101244154B CN101244154B CN 200810057780 CN200810057780A CN101244154B CN 101244154 B CN101244154 B CN 101244154B CN 200810057780 CN200810057780 CN 200810057780 CN 200810057780 A CN200810057780 A CN 200810057780A CN 101244154 B CN101244154 B CN 101244154B
- Authority
- CN
- China
- Prior art keywords
- folic acid
- vitamin
- additive
- appropriate amount
- microcapsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a drug combination for birth defect prevention and memory improving in prepotency, comprising Largehead Atractylodes Rhizome, medlar, root of herbaceous peony, compound vitamin B and microelements zinc and selenium. The drug combination has the advantages of good effect on birth defect prevention and memory improving in prepotency, efficacy of health care and invigoration and no any side effect even with long-term application.
Description
Technical field: the present invention relates to the Medicines and Health Product technical field.Pharmaceutical composition in particular for prenatal and postnatal care prevention birth defect and improvement memory.
Background technology: birth defect refers to fetus in parent in organ formative process, and is disorderly by the fetal development due to the various factors effect, comprises that morphosis is abnormal, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.China's Prevalence rate of birth defect is up to 5% left and right of birth sum, the defective infant that just displays after annual Congenital Malformed Children and birth several months, the developmental disability child up to 1,000,000 people about.Great on the population quality impact, cause white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo is subject to the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
By the prenatal diagnosis termination of pregnancy, can reduce the generation of birth defect; The defective youngster who has been born can realize certain attractive in appearance or improvement by shaping, reparation and treatment, but this mends the fold after the sheep is lost after all.Reducing and prevent birth defect by various preventive measures is to improve the preferred policy of prenatal and postnatal care.
Pharmaceutical composition of the present invention is the policy of following prenatal and postnatal care, by eliminating the harmful factor to the embryo, the generation of prevention birth defect, reach prenatal and postnatal care and lower the purpose of birth defect sickness rate, simultaneously user is improved the effect of memory and intelligence and antiabortive fetus nourishing, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba, compound vitamin B and trace element zinc and selenium, and wherein compound vitamin B comprises vitamin B
1, B
6, B
12And folic acid.
The Rhizoma Atractylodis Macrocephalae is a kind of natural Chinese medicine, and invigorating the spleen and benefiting QI is arranged, the dampness diuretic, the hidroschesis consolidating superficial resistance, and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; Modern clinic is multiplex in cirrhotic ascites, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, and reduce the content of peroxide, avoid harmful substance to the destruction of cellularity and function; And be improved the active trend of SOD, the ability of enhancing body to free radical scavenging, thereby the damage of minimizing radical pair body.2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppress simultaneously the brain activity of monoamine oxidase, (monoamine oxidase, MAO is the old and feeble material of brain), can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects.3, the Rhizoma Atractylodis Macrocephalae has the enhancing immunization, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system.4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external, the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, Chromatin condensation, cell do not divide or seldom division.5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood body weight to increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or radiotherapy tumor.Rhizoma Atractylodis Macrocephalae antioxidation can stop peroxide and radical pair embryo's damage; Rhizoma Atractylodis Macrocephalae inhibition monoamine oxidase, MAO and erythrocyte autoxidation haemolysis can play the protective effect to the embryo; The Rhizoma Atractylodis Macrocephalae strengthens the effect of immunity can resist biological factor to embryo's infringement.The Rhizoma Atractylodis Macrocephalae suppresses activity and the antioxidation of brain mono-oxygenase, to improving memory and intelligence, positive effect is arranged.The antiabortive fetus nourishing of the Rhizoma Atractylodis Macrocephalae should be combined with modern medicine and fully develop and utilize in the existing long history clinically of motherland's medical science.
Fructus Lycii is a kind of natural Chinese medicine, and liver and kidney tonifying is arranged, nourishing YIN and supplementing blood, and replenishing vital essence to improve eyesight, the effect of nourishing the lung to arrest cough is flat tonic thing simply.Ancient Chinese medicine is classified Fructus Lycii as on Chinese medicine product, wherein " book on Chinese herbal medicine converge with speech " to evaluation especially high, think that it has the advantage of tens kinds of Chinese medicines concurrently, claims it: " gas can be filled, and blood can be mended, Yang Kesheng, the moon can be grown, fire can fall, rheumatism can be gone." being mainly used in Liver and kidney two void, the soreness of the waist and knees of asthenia of essence and blood is had a dizzy spell, early whitening of beard and hair, visual deterioration, the diseases such as sexual hypofunction.Modern pharmacological research confirms that Fructus Lycii has: 1, strengthen immunity and reconcile immune effect; 2 anti-cancer and inhibiting tumor effects: 3, remove harmful free radical in body, fat-reducing liver-protecting effect; 4, hypoglycemic activity; 5, resisting fatigue and high temperature resistance effect; 6, strengthen the animal heart, cerebral tissue catalase, the activity of lactic acid dehydrogenase can make superoxide dismutase activity rising in old human blood, and LPO reduces, hematopoietic stem cell is strengthened, have the effect of defying age and stimulating animal growth promoter; 7, promote the function of intelligence and improvement memory.The Fructus Lycii nature and flavor are gentle, have many useful value to promoting human physiological metabolism's function.
The Radix Paeoniae Alba is a kind of natural Chinese medicine, the yin fluid astringing that nourishes blood, and suppressing liver-YANG, the effect of easing the affected liver to relieve pain is mainly used in the headache feeling of fullness in the head of deficiecny of liver-YIN, excessive rising of liver-YANG, vertigo and tinnitus, irritated irritability; Deficiency of liver-blood, battalion defend the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of the wet resistance of deficiency of the liver stasis, abdominal pain during pregnancy; And spontaneous sweating, the gastral cavity abdomen pain over the hypochondriac region, the diseases such as contracture of the limbs pain.Modern pharmacological research confirms that the Radix Paeoniae Alba has: 1, coronary artery dilator increase myocardial nutritional flow amount and anti-platelet aggregation, antithrombotic effect; 2, protect the liver, reduce transaminase's effect; 3, gastrointestinal smooth muscle, vascular smooth muscle, uterine smooth muscle all there are inhibitory action, can alleviate gastrointestinal and uterine smooth muscle spasm, and have slight hypotensive activity; 4, antibacterial, antiinflammatory, analgesic activity; 5, calm, anticonvulsant action; 6, the effect of antiulcer, raising immunity of organisms and hypoxia-bearing capability.In the Chinese Traditional Medicine prescription, the compatibility that the Radix Paeoniae Alba and the Rhizoma Atractylodis Macrocephalae or the Radix Paeoniae Alba and Fructus Lycii or three have concurrently all has the effect of harmonizing.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises a variety of vitamin, and the vitamin that wherein relates to prevention birth defect and improvement memory and intelligence mainly contains vitamin B
1, B
6, B
12And folic acid.Vitamin B
1Have the effect of keeping the nervous system normal function, occur carbohydrate metabolism during shortage incomplete, the phenomenon such as heat energy is under-supply, thus cause hypomnesis, affect the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, can improve memory, concentration power and learning capacity; Vitamin B in addition
1Suppress in addition cholinesterase, improve the function of cholinergic nerve.Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn.Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and metabolism fatty and sugar, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin function complete has certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, impact is to blood supply in brain.Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and during shortage, normal cell can not carry out mitosis, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by the serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is important neurotransmitter in human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with the homotype cysteine of removing in human body, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain.There are some researches show, homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; Homocysteine energy inducing embryo gene differential expression, so it is also the virulence factor of all kinds birth defect.Homocysteine also can cause miscarriage, premature labor in addition, the clinical disastrous effect such as preeclampsia.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid; It is the necessary material of more than 200 kind of zinc dependence enzyme in human body, and the existence of zinc enzyme is arranged in six large fermentoids; Zinc is also the essential element that strengthens immune vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase.Zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, causes glucose tolerance curve abnormal; Anemia of pregnant woman's zinc deficiency can affect the growth promoter of fetus to some extent, so that causes all deformities of fetus; Zinc deficiency can cause brain development bad, incomplete development of mind.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the effect of superabundant fats metabolism in acceleration bodies; Selenium also has the strong anti-oxidation function; the protection embryo is not subjected to the injury of superoxides; prevention of cardiac; anticancer by strengthening immune recognition system to remove cancerous cell; remove and the excretion heavy metal ion; hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor.Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and accelerates human senility and intelligence decline.
China's Ministry of Public Health has been listed the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba in the article list that can be used for health food, and it is namely that food is also the list of medicine that Fructus Lycii is listed in.
Application contains vitamin B
1, B
6, B
12, folic acid and the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba and trace element zinc, selenium is known as the compositions of active component, but with vitamin B
1, B
6, B
12, folic acid and the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba and trace element zinc, selenium compatibility not yet report as prenatal and postnatal care prevention birth defect and the pharmaceutical composition that improves memory.
Factor due to the childbearing age, psychic trauma or stress factor, pathology or medication factor, dietetic life custom or the reasons such as nutritional imbalance and environmental pollution have a very large colony because the Deficiency of Intake of aforementioned one or more electrolytes and minerals causes hypomnesis, intelligence decline or dysnoesia to affect normal operation, living and studying.The normal development that also has a strong impact on simultaneously fetus even causes birth defect.Current medicine or health food kind for improving memory has multiplely, but effect is all undesirable, and the medicine or the health food that are used for improving memory and intelligence that aim at pregnant front women, anemia of pregnant woman, wet nurse's development are not yet seen.The function of melatonin is to improve sleep, and has little or nothing to do with the improvement memory.The medicine that is used for the prevention birth defect is not yet seen, and is used for the rarely seen Si Lian of medicine of prevention neural tube defects, and the function composition only has a kind of active ingredient of folic acid, and its target spot is few, the link shortcoming, and effect is undesirable, and clinical value needs perfect.
Summary of the invention: in order to overcome the shortcoming and defect of existing prenatal and postnatal care prevention birth defect and/or improvement memory and intelligence medicine, the purpose of this invention is to provide a kind of compositions, said composition is passed through vitamin B
1, B
6, B
12, folic acid and trace element zinc, selenium increases the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Paeoniae Alba brain healthy, improve memory and the effects such as antiabortive fetus nourishing, nourishing YIN and supplementing blood, simultaneously by effects such as the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the antiabortive fetus nourishing of the Radix Paeoniae Alba, nourishing YIN and supplementing blood, replenish and strengthen compound vitamin B and trace element zinc, selenium, the prevention birth defect is also improved the effect of memory and intelligence; Reach the purpose of prenatal and postnatal care; Even chronic administration is also without any side effect.Due to the result of broad research, the inventor has found vitamin B
1, B
6, B
12, folic acid, zinc, selenium and the Rhizoma Atractylodis Macrocephalae, the novel combination of Fructus Lycii, the Radix Paeoniae Alba, this novel combination is for prenatal and postnatal care prevention birth defect and improve memory and intelligence has synergy.And alone compound vitamin B and trace element zinc, selenium and Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba, its effect is all not as good as this compositions.And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of this compositions dosage used, invigorating the spleen and benefiting QI is arranged, the dampness diuretic, the hidroschesis consolidating superficial resistance, and in antiabortive effect; Fructus Lycii has the effect of liver and kidney tonifying, nourishing YIN and supplementing blood, replenishing vital essence to improve eyesight, nourishing the lung to arrest cough; The Radix Paeoniae Alba yin fluid astringing that nourishes blood, suppressing liver-YANG, the effect of easing the affected liver to relieve pain.Trace element zinc is the necessary material of six large class 200 plurality of enzymes in human body, is also the essential element that strengthens immune vigor; But in the trace element-selenium acceleration bodies, the metabolism of superabundant fats, have the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc.Vitamin B and for example
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
6Can eliminate intraepithelial neoplasia cells, strengthen immunologic function, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias, and neural disease; Folic acid also has cardioprotection and antitumaous effect.There is not incompatibility in this compositions, has no side effect, and sufficient raw, and cost is low, except prevention birth defect and improvement memory, to being subjected to the user, the health care benefiting action is arranged still, and be that the good health and a long life of benefiting from after fetus is born are laid a good foundation, thereby consist of the present invention.
The invention provides for prenatal and postnatal care prevention birth defect and improve the compositions of remembering, it comprises the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba and vitamin B as active component
1, B
6, B
12, folic acid and trace element zinc, selenium.
The Rhizoma Atractylodis Macrocephalae is the rhizome of the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala Koidz).Main product in Zhejiang, the ground such as Hubei, Hunan.Gather winter, dries or dry, and life use or parching with earth, parched with bran are used.
Fructus Lycii is the mature fruit of matrimony vine of solanaceae plant (L.chinense mill).The ground such as main product Ningxia, Xinjiang; Have another name called Fructus Lycii, FRUCTUS LYCII, day essence, ground celestial being etc.
The Radix Paeoniae Alba is the root of Ranunculaceae herbaceos perennial Radix Paeoniae (Paeonia Lactiflora Pall).Main product in Zhejiang, the ground such as Anhui, Sichuan; Summer, Qiu Erji excavated, and put and removed crust after boiling in boiling water, or boil after peeling again, to without hard-core, picked up and dried; Shave is used.
Be used for compound vitamin B of the present invention and include vitamin B
1(VitaminB
1), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), are all water soluble vitamins, do not accumulate in vivo; Zinc and selenium are micro elements needed by human; Professional production factory and supplier are all arranged.
The Rhizoma Atractylodis Macrocephalae of the present invention, Fructus Lycii, the Radix Paeoniae Alba can be with its extract as raw material; Compound vitamin B of the present invention and trace element zinc, selenium each component can be with pharmaceutical grade or the food additive grade raw materials as this compositions.
Compositions of the present invention mainly is applicable to pregnant early stage women, anemia of pregnant woman and wet nurse.By the present invention, the effective dose of the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba take whole crude drug according to the administration period length Rhizoma Atractylodis Macrocephalae as 200-15000mg/ days, Fructus Lycii is 200-15000mg/ days, the Radix Paeoniae Alba is 200-15000mg/ days, and vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
6Effective dose be 0.5-5mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, the effective dose of trace element zinc is 10-30mg/ days, the effective dose of selenium is 0.03-0.3mg/ days.
compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), to mix and prepare with other known additive, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, coating agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc., be prepared or they are added food as functional component or additive by usual way.
By the present invention, single component and the vitamin B of the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba
1, B
6, B
12, folic acid and trace element zinc, selenium each component can distinguish preparation, use after the preparation of each component can being mixed when using or do not mix simultaneously and use.
Advantage of the present invention is that this compositions has significant effect to prenatal and postnatal care prevention birth defect and improvement memory, sufficient raw, cost is low, in compositions, each component has no side effect, without incompatibility, except prenatal and postnatal care prevention birth defect and improvement memory, human body still there is the health care benefiting action.
Subordinate list 1 be this compositions with the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Paeoniae Alba group and compound vitamin B and trace element zinc, the young rat/mouse labyrinth test effect of selenium group relatively.
Subordinate list 2 be this compositions with the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Paeoniae Alba group and compound vitamin B and trace element zinc, selenium group Aged Mice maze test effect relatively.
Be described in detail the present invention below with reference to embodiment and test implementation example effect comparison list.
Embodiment 1:
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 3
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 5
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 6
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 7
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 8
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 9:
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 10:
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 11
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 12
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 13
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 14
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 15
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 16
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 17:
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 18:
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 19
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 20
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 21
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 22
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 23
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 24
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 25:
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 26:
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 27
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 28
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 29
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 30
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 31
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 32
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 33:
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 34:
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 35
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 36
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 37
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 38
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 39
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 40
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 41:
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 42:
Formula:
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and its Folic Acid first coats with microcapsule, then makes 3 bag shot-like particles.Take every day 3 times, each serving a bag.
Embodiment 43
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 44
Formula:
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and its Folic Acid first coats with microcapsule, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 45
Formula:
The additive of the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent are mixed equably make again 3 bag electuaries; First folic acid is coated with microcapsule, then and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent evenly are mixed and made into independent 9; Take each electuary 1 bag, 3, tablet every day 3 times.
Embodiment 46
Formula:
The additive of the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent are mixed equably make again 3 bag electuaries; First folic acid is coated with microcapsule, then and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent evenly are mixed and made into independent 9; Take each electuary 1 bag, 3, tablet every day 3 times.
Embodiment 47
Formula:
The additive of the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent are mixed equably make again 3 bag electuaries; First folic acid is coated with microcapsule, then and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent evenly are mixed and made into independent 9; Take each electuary 1 bag, 3, tablet every day 3 times.
Embodiment 48
Formula:
The additive of the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent are mixed equably make again 3 bag electuaries; First folic acid is coated with microcapsule, then and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent evenly are mixed and made into independent 9; Take each electuary 1 bag, 3, tablet every day 3 times.
Belong to nontoxic level through animal experiment proved compositions; The crowd takes and also has no toxicity.
Subordinate list 1: this compositions and the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba and compound vitamin B and trace element zinc, selenium are respectively organized young rat/mouse labyrinth test effect relatively:
Subordinate list 2: this compositions and the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Radix Paeoniae Alba and compound vitamin B and trace element zinc, selenium are respectively organized Aged Mice maze test effect relatively:
Annotate: in subordinate list 1, subordinate list 2, each group was tested by dosage feed in table respectively in 60 days; In table, consumption converts by per kilogram of body weight; Zinc, selenium are in trace element.
Select 80 of newly-married healthy womens, 25 years old mean age, take continuously this compositions from beginning in pregnant front 3 months, followed up a case by regular visits to none routine birth defect to the baby due in 6 months.With associated materials statistics contrasts, the annual Fetal malformation of China accounts for the 4-6% of newborn population sum, and there were significant differences.
Can obviously find out from table 1, table 2, this compositions by rat/mouse labyrinth test with compositions in Chinese medicine component and compound vitamin B and trace element component contrast, the statistical result of mistake percentage rate is better than simple Chinese medicine component or compound vitamin B and trace element component on the function of the memory of this composition for improved and intelligence; With the blank group, significant difference is arranged relatively.
Claims (1)
1. be used for prenatal and postnatal care prevention birth defect and improve the pharmaceutical composition of remembering, it is characterized in that, it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 200-15000mg,
Fructus Lycii 200-15000mg,
Radix Paeoniae Alba 200-15000mg,
Vitamin B
60.5-5mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10.5-20mg,
Zinc is in the zinc 10-30mg of trace element zinc,
Selenium is in the selenium 0.03-0.3mg of trace element-selenium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810057780 CN101244154B (en) | 2008-02-18 | 2008-02-18 | Pharmaceutical combination for bearing and rearing better children, preventing birth defect and improving anamnesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810057780 CN101244154B (en) | 2008-02-18 | 2008-02-18 | Pharmaceutical combination for bearing and rearing better children, preventing birth defect and improving anamnesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101244154A CN101244154A (en) | 2008-08-20 |
| CN101244154B true CN101244154B (en) | 2013-06-05 |
Family
ID=39944975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200810057780 Expired - Fee Related CN101244154B (en) | 2008-02-18 | 2008-02-18 | Pharmaceutical combination for bearing and rearing better children, preventing birth defect and improving anamnesis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101244154B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366867B (en) * | 2008-09-22 | 2012-05-30 | 北京冠五洲生物科学研究院 | Medicament composition for preventing birth defect and improving memory |
| CN101366872B (en) * | 2008-09-22 | 2012-07-04 | 北京冠五洲生物科学研究院 | Medicament composition for preventing birth defect and improving memory |
-
2008
- 2008-02-18 CN CN 200810057780 patent/CN101244154B/en not_active Expired - Fee Related
Non-Patent Citations (5)
| Title |
|---|
| 张安镛.多种维生素及微量元素制剂的开发及其在妇女妊娠期的应用.《世界临床药物(国外药学-合成药、生化药、制剂分册)》.1986,第7卷(第6期),342-346. * |
| 李恒华等.浅谈白术的研究、应用及开发重点.《重庆中草药研究》.2007,(第2期),55-61. * |
| 蒋午峻等.白芍总苷的药理作用和质量控制方法研究进展.《河北医科大学学报》.2006,第27卷(第5期),500-502. * |
| 计晶晶等.枸杞对D2半乳糖致衰老小鼠学习记忆影响.《中国公共卫生》.2007,第23卷(第3期),359-360. * |
| 钱彦丛等.枸杞子的化学成分及药理研究新进展.《中医药学报》.2000,(第4期),33-35. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101244154A (en) | 2008-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101366868A (en) | Medicament composition for preventing birth defect, improving memory and intelligence | |
| CN101396419A (en) | Medicine composition for preventing the birth defect and improving the memory | |
| CN101244154B (en) | Pharmaceutical combination for bearing and rearing better children, preventing birth defect and improving anamnesis | |
| CN101264140A (en) | Medicinal composition for preventing birth defect and improving memory and intelligence | |
| CN101306042A (en) | Medicine composition for preventing the birth defect and improving the memory | |
| CN101293024A (en) | Pharmaceutical combination for preventing birth defect and improving anamnesis | |
| CN101390892A (en) | Medicine composition for preventing the birth defect and improving the memory and intelligence | |
| CN101332257A (en) | Medicine composition for preventing the birth defect and improving the memory | |
| CN101371865A (en) | Pharmaceutical combination for preventing birth-defect and improving memory and intelligence | |
| CN101361780A (en) | Medicine composition for preventing the birth defect and improving the memory | |
| CN101366751A (en) | Medicament composition for preventing birth defect and improving memory and intelligence | |
| CN101297905A (en) | Pharmaceutical combination for preventing birth-defect and improving memory and intelligence | |
| CN101366805A (en) | Medicament composition for preventing birth defect and improving memory and intelligence | |
| CN101385752A (en) | Medicine composition for preventing the birth defect and improving the memory | |
| CN101375916A (en) | Pharmaceutical combination for preventing birth-defect and improving memory and intelligence | |
| CN101375908A (en) | Pharmaceutical combination for preventing birth-defect and improving memory and intelligence | |
| CN101297699A (en) | Pharmaceutical combination for preventing birth-defect and improving memory and intelligence | |
| CN101306068A (en) | Medicine composition for preventing the birth defect and improving the memory | |
| CN101406616A (en) | Pharmaceutical combination for preventing birth-defect and improving memory and intelligence | |
| CN101306039A (en) | Medicine composition for preventing the birth defect and improving the memory | |
| CN101422499A (en) | Medicine composition for preventing the birth defect and improving the memory | |
| CN101406507A (en) | Pharmaceutical combination for preventing birth-defect and improving memory and intelligence | |
| CN101361852A (en) | Medicine composition for preventing the birth defect and improving the memory and intelligence | |
| CN101396513A (en) | Medicine composition for prenatal and postnatal care and preventing the birth defect and improving the memory | |
| CN101342308A (en) | Medicament composition for preventing birth defect and improving memory |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| DD01 | Delivery of document by public notice |
Addressee: Beijing Guanwuzhou Biological Scientific Institute Document name: Notification to Pay the Fees |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130605 Termination date: 20150218 |
|
| EXPY | Termination of patent right or utility model |