CN101366805A - Medicament composition for preventing birth defect and improving memory and intelligence - Google Patents
Medicament composition for preventing birth defect and improving memory and intelligence Download PDFInfo
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- CN101366805A CN101366805A CNA2008102231503A CN200810223150A CN101366805A CN 101366805 A CN101366805 A CN 101366805A CN A2008102231503 A CNA2008102231503 A CN A2008102231503A CN 200810223150 A CN200810223150 A CN 200810223150A CN 101366805 A CN101366805 A CN 101366805A
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- atractylodis macrocephalae
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Abstract
The invention relates to a medical composition for preventing birth defects and improving memory and intelligence, which comprises Langehead Atractylodes Rhizome, rhodiola, vitamin B complex, and trace elements of zinc and selenium. The medical composition is mainly suitable for pregestational women, pregnant women and wet nurses, is very effective in preventing the birth defects and improving the memory and the intelligence, has both health care and tonic efficacies, and does not generate any side effects even after long-term application.
Description
Technical field: the present invention relates to the Medicines and Health Product technical field; Pharmaceutical composition in particular for prevention birth defect and improvement memory and intelligence.
Background technology: birth defect is meant that fetus is in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprise that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.; China's birth defect incidence rate is up to about 5% of the birth sum, annual youngster in congenital malformation and the defective infant that just displays after the birth several months, the developmental disability child up to 1,000,000 people about, great to the population quality influence, cause white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor; Environmental factors comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the harmful factor to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate, simultaneously user there are the effect that improves memory and intelligence and antiabortive fetus nourishing, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae, compound vitamin B and trace element zinc and selenium, and wherein compound vitamin B comprises vitamin B
1, B
6, B
12And folic acid.
The Rhizoma Atractylodis Macrocephalae is a kind ofly can invigorating the spleen and benefiting QI be arranged as the QI invigorating class natural Chinese medicine of health food, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, and reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function; And SOD activity improving trend is arranged, and enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body; 2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppress the brain activity of monoamine oxidase simultaneously, (monoamine oxidase, MAO is the old and feeble material of brain), can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects; 3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system; 4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division; 5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor; Traditional Chinese medical science custom in prescription the compatibility Rhizoma Atractylodis Macrocephalae with the absorption, particularly compatibility gold that promote the medicine active ingredient, stone class medicine to promote the absorption and the utilization of mineral.
Radix Rhodiolae is a kind ofly can benefiting vital QI for tranquillizing be arranged as the natural Chinese medicine of health food, clearing heat and moistening lung, the effect that hemostasis is invigorated blood circulation; Clinical being used for the treatment of a little less than the empty gas of body, palpitation and insomnia, dyspnea and cough due to lung-heat, void is coughed chronic cough, heat in blood hemoptysis, diseases such as traumatic injury; Modern pharmacological research confirms that Radix Rhodiolae has: 1, brain healthy effect; 2, resisting fatigue, resisting oxygen lack; 3, anti-aging effects; 4, antitumor action; 5, arrhythmia and the effect of protection heart; 6, enhance immunity effect; 7, internal organs such as kidney, lung, liver had protective effect; 8, antinoise effect; 9, antivirus action; 10, resisting microwave radiation effect etc.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises a variety of vitamin, and the vitamin that wherein relates to prevention birth defect and improvement memory and intelligence mainly contains vitamin B
1, B
6, B
12And folic acid; Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; Homocysteine energy inducing embryo gene differential expression, so it also is the virulence factor of all kinds birth defect; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid; It is the necessary material of more than 200 kind of zinc dependence enzyme in the human body, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve; Anemia of pregnant woman's zinc deficiency can influence the growth promoter of fetus to some extent, so that causes all deformities of fetus; Zinc deficiency can cause brain development bad, incomplete development of mind.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, the protection embryo is not subjected to the injury of superoxides, prevention of cardiac, anticancer by enhance immunity recognition system removing cancerous cell, remove and drain heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.
Application contains vitamin B
1, B
6, B
12, folic acid and the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and trace element zinc, selenium has been known as the compositions of active component, but with vitamin B
1, B
6, B
12, folic acid and the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and trace element zinc, selenium compatibility be as prevention birth defect and the pharmaceutical composition that improves memory and intelligence report as yet.
Current medicine that is used to improve memory or health food kind have multiple, and aim at pregnant before the medicine or the health food that are used to improve memory and intelligence of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen relevant folic acid is used to prevent the report of neural tube defects; Its target spot is few, and the link shortcoming needs perfect; And will prevent the effect of birth defect and improvement memory and intelligence and be used for same medicine person not see as yet.
Summary of the invention: in order to overcome the shortcoming and defect of existing prevention birth defect and/or improvement memory and intelligence medicine, the purpose of this invention is to provide a kind of compositions, said composition is passed through vitamin B
1, B
6, B
12, folic acid and trace element zinc, selenium increases the effect of the antiabortive and Rhizoma Atractylodis Macrocephalae of Rhizoma Atractylodis Macrocephalae fetus nourishing and Radix Rhodiolae brain healthy, antioxidation, defying age, enhance immunity, antitumor, blood lipid-reducing blood sugar-decreasing; Promote the absorption and the utilization of vitamin, mineral simultaneously by the Rhizoma Atractylodis Macrocephalae, and replenish and strengthen compound vitamin B and trace element zinc, selenium, prevention birth defect and improve the effect of memory and intelligence with Radix Rhodiolae is collaborative; Even chronic administration is also without any side effect; Because the result of broad research, the inventor has found vitamin B
1, B
6, B
12, folic acid, zinc, selenium and the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae novel combination, this novel combination is for the prevention birth defect and improve memory and intelligence has synergy; And it is single with compound vitamin B and trace element zinc, selenium and the Chinese medicine Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae, its effect is all not as good as this compositions, and the effective ingredient of each component has the addition complementary action to the health care tonification of human body, the Rhizoma Atractylodis Macrocephalae as the used dosage of this compositions has invigorating the spleen and benefiting QI, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Radix Rhodiolae has the effect that benefiting vital QI for tranquillizing, clearing heat and moistening lung, hemostasis invigorate blood circulation and the effect of brain healthy; Trace element zinc is the necessary material of six big class 200 plurality of enzymes in the human body, also is the essential element of enhance immunity vigor; But the metabolism of superabundant fats has the strong anti-oxidation function, prevention of cardiac function, anti-cancer function etc. in the trace element-selenium acceleration bodies; Vitamin B and for example
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the compositions that is used to prevent birth defect and improves memory and intelligence, it comprises the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and vitamin B as active component
1, B
6, B
12, folic acid and trace element zinc, selenium.
The Rhizoma Atractylodis Macrocephalae is a Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae Atractylodes macrocephaia koidz rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and life usefulness or parching with earth, parched with bran are used.The used Rhizoma Atractylodis Macrocephalae of the present invention can be with its extract as raw material.
Radix Rhodiolae is that root, stem or the Herb of Crassulaceae rhodiola herbaceos perennial or semishrub plant's Radix Rhodiolae (RhodiolaSPP.) supplies to use, kind surplus having 80, mainly contain Radix Rhodiolae (R.crenulata), Rhodiola kirilowii (Regel) Maxim. (R.kirilowil), Radix Rhodiolae (R.sacra) etc., China accounts for 90% resource, mainly is distributed in ground such as Qinghai-Tibet Platean and northeast, North China, northwest; Tibetan language claims " Suo Luomabu ", and the title of " plateau Radix Ginseng " is arranged; The used Radix Rhodiolae of the present invention can be with its extract as raw material.
Be used for compound vitamin B of the present invention and include vitamin B
1(VitaminB
1), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (Folic Acid), all are water soluble vitamins, do not accumulate in vivo; Zinc and selenium are micro elements needed by human, wherein, trace element zinc can be selected zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, zinc citrate for use, zinc gluconate etc., trace element-selenium can be selected Selenomethionine, selenocarrageenan, selenocysteine, selenizing methionine, selenium yeast, sodium selenite etc. for use; Professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom and Time of Administration length, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 300-15000mg/ days with whole crude drug, and the effective dose of Radix Rhodiolae extract is counted 300-f0000mg/ days with whole crude drug, and vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae, vitamin B
1, B
6, B
12, folic acid and trace element zinc, selenium each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, to preventing birth defect and improvement memory and intelligence that significant effect is arranged, sufficient raw, cost is low, and each component has no side effect in the compositions, no incompatibility, except that prevention birth defect and improvement memory and intelligence, human body still there is the health care benefiting action.
Subordinate list 1 be this compositions with the Rhizoma Atractylodis Macrocephalae and Radix Rhodiolae group and compound vitamin B and trace element zinc, the young rat/mouse labyrinth test effect of selenium group relatively.
Subordinate list 2 be this compositions with the Rhizoma Atractylodis Macrocephalae and Radix Rhodiolae group and compound vitamin B and trace element zinc, selenium group Aged Mice maze test effect relatively.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Prescription:
Rhizoma Atractylodis Macrocephalae 5000mg (by whole crude drug),
Radix Rhodiolae 500mg (by whole crude drug),
Vitamin B
12mg,
Vitamin B
61.5mg,
Vitamin B
120.003mg,
Folic acid 0.6mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, and wherein folic acid coats with microcapsule earlier, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Prescription:
Rhizoma Atractylodis Macrocephalae 600mg (by whole crude drug),
Radix Rhodiolae 500mg (by whole crude drug),
Vitamin B
62mg,
Vitamin B
120.008mg,
Folic acid 0.8mg.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, and wherein folic acid coats with microcapsule earlier, makes 3 bag shot-like particles again.Obey every day 3 times, obey a bag at every turn.
Embodiment 3:
Prescription:
Rhizoma Atractylodis Macrocephalae 5000mg (by whole crude drug),
Radix Rhodiolae 500mg (by whole crude drug),
Vitamin B
11.8mg,
Vitamin B
60.8mg,
Vitamin B
120.01mg,
Folic acid 1 0.9mg,
Zinc citrate 20mg (in element zinc).
With the additive of the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent, mix and make 3 bag electuaries more equably; Earlier folic acid is coated with microcapsule, again and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9; Obey each electuary 1 bag, 3 in tablet every day 3 times.
Embodiment 4:
Prescription:
Rhizoma Atractylodis Macrocephalae 1000mg (by whole crude drug),
Radix Rhodiolae 400mg (by whole crude drug),
Vitamin B
11.8mg,
Vitamin B
60.8mg,
Vitamin B
120.01mg,
Folic acid 0.2mg,
Selenomethionine 0.05mg (in elemental selenium).
With the additive of the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent, mix and make 3 bag electuaries more equably; Earlier folic acid is coated with microcapsule, again and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9; Obey each electuary 1 bag, 3 in tablet every day 3 times.
Embodiment 5:
Prescription:
Rhizoma Atractylodis Macrocephalae 2000mg (by whole crude drug),
Radix Rhodiolae 500mg (by whole crude drug),
Vitamin B
60.8mg,
Vitamin B
120.01mg,
Folic acid 0.3mg,
Zinc citrate 10mg (in element zinc),
Selenomethionine 0.05mg (in elemental selenium).
With the additive of the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent, mix and make 3 bag electuaries more equably; Earlier folic acid is coated with microcapsule, again and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9; Obey each electuary 1 bag, 3 in tablet every day 3 times.
Embodiment 6:
Prescription:
Rhizoma Atractylodis Macrocephalae 2000mg (by whole crude drug),
Radix Rhodiolae 600mg (by whole crude drug),
Vitamin B
60.8mg,
Vitamin B
120.01mg,
Folic acid 0.4mg,
Zinc citrate 6mg (in element zinc).
With the additive of the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent, mix and make 3 bag electuaries more equably; Earlier folic acid is coated with microcapsule, again and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9; Obey each electuary 1 bag, 3 in tablet every day 3 times.
Embodiment 7:
Prescription:
Rhizoma Atractylodis Macrocephalae 8000mg (by whole crude drug),
Radix Rhodiolae, 8000mg (by whole crude drug),
Vitamin B
60.8mg,
Vitamin B
120.01mg,
Folic acid 0.3mg,
Selenomethionine 0.05mg (in elemental selenium).
With the additive of the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent, mix and make 3 bag electuaries more equably; Earlier folic acid is coated with microcapsule, again and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9; Obey each electuary 1 bag, 3 in tablet every day 3 times.
Embodiment 8:
Prescription:
Rhizoma Atractylodis Macrocephalae 300mg (by whole crude drug),
Radix Rhodiolae 300mg (by whole crude drug),
Vitamin B
10.5mg,
Vitamin B
60.5mg,
Vitamin B
120.001mg,
Folic acid 0.1mg,
Zinc citrate 5mg (in element zinc),
Selenomethionine 0.015mg (in elemental selenium).
With the additive of the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent, mix and make 3 bag electuaries more equably; Earlier folic acid is coated with microcapsule, again and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9; Obey each electuary 1 bag, 3 in tablet every day 3 times.
Embodiment 9:
Prescription:
Rhizoma Atractylodis Macrocephalae 15000mg (by whole crude drug),
Radix Rhodiolae 10000mg (by whole crude drug),
Vitamin B
120mg,
Vitamin B
610mg,
Vitamin B
120.025mg,
Folic acid 1mg,
Zinc citrate 20mg (in element zinc),
Selenomethionine 0.1mg (in elemental selenium).
With the additive of the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae and appropriate amount such as sodium citrate, malic acid, sucrose, benzoic acid and flavoring agent, mix and make 3 bag electuaries more equably; Earlier folic acid is coated with microcapsule, again and vitamin B
1, B
6, B
12, zinc, selenium and appropriate amount starch, polyvinyl pyrrolidone, light anhydrous silicic acid, Polyethylene Glycol and flavoring agent uniform mixing are made independent 9; Obey every day 3 times, each electuary 1 bag, 3 in tablet serve on 3, withdraws at 3 days at 2 taking medicine twice a days.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Rhodiolae and compound vitamin B and trace element zinc, selenium are respectively organized young rat/mouse labyrinth test effect relatively:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 21.6％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Rhodiolae group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Rhodiolae 50mg/ days | 12 | 18.6％ |
| The C group | Compound vitamin B+trace element group | VB 10.1mg+VB 60.08mg+VB12 0.2mg/ days+selenium of 0.008mg/ days+zinc of 0.0001mg+ folic acid 0.001mg/ days | 12 | 18.7％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Rhodiolae+compound vitamin B+trace element group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Rhodiolae 50mg+ VB 10.1mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg/ days+zinc 0.2mg/ days+selenium 0.001mg/ days | 12 | 17％ |
Subordinate list 2: this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Rhodiolae and compound vitamin B and trace element zinc, selenium are respectively organized Aged Mice maze test effect relatively:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 53.3％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Rhodiolae group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Rhodiolae 50mg/ days | 12 | 34.4％ |
| The C group | Compound vitamin B+trace element group | VB 10.1mg+VB 60.08mg+VB12 0.2mg/ days+selenium of 0.008mg/ days+zinc of 0.0001mg+ folic acid 0.001mg/ days | 12 | 33.2％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Rhodiolae+compound vitamin B+trace element group | Rhizoma Atractylodis Macrocephalae 100mg+ Radix Rhodiolae 50mg+ VB 10.1mg+VB 60.08mg+VB 120.0001mg+ folic acid 0.008mg/ days+zinc 0.2mg/ days+selenium 0.001mg/ days | 12 | 30.1％ |
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due.With associated materials statistics contrasts, the annual birth defect youngster of China account for the newborn population sum 4-6% there were significant differences.
Can obviously find out from table 1, table 2, this compositions is by the Chinese medicine component in rat/mouse labyrinth test and the compositions and compound vitamin B and the contrast of trace element component, the statistical result of mistake percentage rate is better than simple Chinese medicine component or compound vitamin B and trace element component on the function of memory of this composition for improved and intelligence; With the blank group significant difference is arranged relatively.
Claims (8)
1. pharmaceutical composition that is used to prevent birth defect and improves memory and intelligence is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Rhodiolae 300-10000mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10-20mg,
Zinc 0-20mg,
Selenium 0-0.1mg.
2. the pharmaceutical composition that is used to prevent birth defect and improves memory and intelligence according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Rhodiolae 300-10000mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10-20mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg.
3. the pharmaceutical composition that is used to prevent birth defect and improves memory and intelligence according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Rhodiolae 300-10000mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10-20mg,
Zinc 5-20mg,
Selenium 0-0.1mg.
4. the pharmaceutical composition that is used to prevent birth defect and improves memory and intelligence according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Rhodiolae 300-10000mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10-20mg,
Zinc 0-20mg,
Selenium 0.015-0.1mg.
5. the pharmaceutical composition that is used to prevent birth defect and improves memory and intelligence according to claim 1 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Rhodiolae 300-10000mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10.5-20mg,
Zinc 0-20mg,
Selenium 0-0.1mg.
6. the pharmaceutical composition that is used to prevent birth defect and improves memory and intelligence according to claim 5 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Rhodiolae 300-10000mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10.5-20mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg.
7. the pharmaceutical composition that is used to prevent birth defect and improves memory and intelligence according to claim 5 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Rhodiolae 300-10000mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10.5-20mg,
Zinc 5-20mg,
Selenium 0-0.1mg.
8. the pharmaceutical composition that is used to prevent birth defect and improves memory and intelligence according to claim 5 is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 300-15000mg,
Radix Rhodiolae 300-10000mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Folic acid 0.1-1mg,
Vitamin B
10.5-20mg,
Zinc 0-20mg,
Selenium 0.015-0.1mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102231503A CN101366805A (en) | 2008-09-26 | 2008-09-26 | Medicament composition for preventing birth defect and improving memory and intelligence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102231503A CN101366805A (en) | 2008-09-26 | 2008-09-26 | Medicament composition for preventing birth defect and improving memory and intelligence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101366805A true CN101366805A (en) | 2009-02-18 |
Family
ID=40410897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008102231503A Pending CN101366805A (en) | 2008-09-26 | 2008-09-26 | Medicament composition for preventing birth defect and improving memory and intelligence |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101366805A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103463169A (en) * | 2013-09-18 | 2013-12-25 | 北京利千秋科技发展有限公司 | Pharmaceutical composition for preventing birth defects and improving memory |
-
2008
- 2008-09-26 CN CNA2008102231503A patent/CN101366805A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103463169A (en) * | 2013-09-18 | 2013-12-25 | 北京利千秋科技发展有限公司 | Pharmaceutical composition for preventing birth defects and improving memory |
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