CN101342308A - Medicament composition for preventing birth defect and improving memory - Google Patents
Medicament composition for preventing birth defect and improving memory Download PDFInfo
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- CN101342308A CN101342308A CNA2008101150180A CN200810115018A CN101342308A CN 101342308 A CN101342308 A CN 101342308A CN A2008101150180 A CNA2008101150180 A CN A2008101150180A CN 200810115018 A CN200810115018 A CN 200810115018A CN 101342308 A CN101342308 A CN 101342308A
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Abstract
The present invention relates to a medicinal composition which is used for preventing birth defects and improving memory. The composition comprises Astraolylis lancea formalyrata, dwarf lilyturf root, vitamin A, beta-carotene, composite vitamin B, vitamin C, vitamin D, and vitamin E. The composition is mainly used for pre-pregnant women, pregnant women and nursing mothers, and has significant effects on preventing the birth defects and improving the memory. Simultaneously, the composition has the effects of health care and replenishment. Even in the long-term use, the medicine has no side effects.
Description
Technical field:
The present invention relates to the Medicines and Health Product technical field.Also can improve the pharmaceutical composition of memory in particular for the prevention birth defect.
Background technology:
Birth defect is meant fetus in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprises that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the birth defect factor that causes to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate, simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E.
The Rhizoma Atractylodis Macrocephalae is a kind ofly can invigorating the spleen and benefiting QI be arranged as the QI invigorating class natural Chinese medicine of health food, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, and reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function; And SOD activity improving trend is arranged, and enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body.2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects.3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system.4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division.5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor.Traditional Chinese medical science custom in prescription the compatibility Rhizoma Atractylodis Macrocephalae to promote the absorption of medicine active ingredient.
Be a kind ofly can nourishing lung-YIN be arranged, reinforcing stomach reg fluid, the relieving restlessness that clears away heart-fire, the effect of loosening bowel to relieve constipation as the nourishing YIN class natural Chinese medicine of health food Radix Ophiopogonis; Cure mainly deficiency of YIN chronic cough, interior-heat is quenched one's thirst, vexed insomnia, diseases such as dryness of the intestine constipation; Modern pharmacological research confirms to have Radix Ophiopogonis: 1, improve myocardial contraction and heart pump function; 2, the effect of protection cardiac muscle; 3, Antishock function; 4, oxygen lack resistant function; 5, remove the free radical effect; 6, anti-aging effects; 7, enhance immunity effect; 8, hypoglycemic activity; 9, accelerate the intestinal progradation; 10, antibacterial action etc.
Vitamin A also claims retinol, and the effect that improves vision, prevents nyctalopia is arranged, and the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function is arranged, and can promote mucopolysaccharide synthetic, influences renewal, the growth of osseous tissue, and long bone is grown to both-end; If vitamin A deficiency is prone to premature labor or fetal congenital deformity.Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Having another name called riboflavin, is the ingredient of many important coenzyme in the body, and it participates in intravital substance metabolism, promotes fetus and baby's growth promoter to play an important role vitamin B to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin C claims ascorbic acid again.Vitamin C and collagen in close relations, the vessel softening effect is not only arranged, the effect that purifies the blood in addition, prevent arteriosclerosis, can also promote the absorption of human body to ferrum in the food, for hemopoietic provides essential raw material, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, subcutaneous hemorrhage can appear in anemia of pregnant woman's hypovitaminosis C or deficiency, swelling and aching of gum, symptom such as bleed, fester, the long-term lacking vitamin C easily has virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, the function unanimity, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption, the then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest.Have the effect of eliminating free radical, slow down aging, prevention maxicell hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or anemia of pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell hemolytic anemia and red blood cell life span shortening can take place also.
Application contains the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E has been known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E compatibility is used for prenatal and postnatal care prevention birth defect and can improves the pharmaceutical composition of remembering and report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen report that folic acid prevention neural tube defects is arranged; But its target spot is few, and the link shortcoming needs perfect.Do not see as yet and will prevent birth defect also can improve the effect of memory and be used for same medicine person.
Summary of the invention:
In order to overcome existing prevention birth defect and/or to improve the shortcoming and defect of remembering medicine, the purpose of this invention is to provide a kind of compositions, said composition promotes the absorption and the utilization of vitamin by the Rhizoma Atractylodis Macrocephalae, and with collaborative vitamin A, beta-carotene, the vitamin B of increasing Radix Ophiopogonis
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E improves the effect of memory and prevention birth defect, simultaneously by vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the antiabortive and Rhizoma Atractylodis Macrocephalae of Rhizoma Atractylodis Macrocephalae fetus nourishing with Radix Ophiopogonis anti-sorrow always, effects such as anti-hypoxia, removing free radical, enhance immunity; Even chronic administration is also without any side effect.Because the result of broad research, the inventor have found the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E novel combination, this novel combination is for the prevention birth defect and can improve to remember synergy is arranged; And singly use the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions have that fetus nourishing is antiabortive, the effect of defying age, enhance immunity, physical strength reinforcing; Nourishing lung-YIN, reinforcing stomach reg fluid are arranged Radix Ophiopogonis, clear away heart-fire and remove effect dry, loosening bowel to relieve constipation; Vitamin A has the raising vision, prevents the effect of nyctalopia; Vitamin B
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin C has vessel softening, purifies the blood, prevents arteriosclerotic effect; Vitamin E has the free radical of removing, function in delaying senility; The effect of vitamin D protection skeleton.There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides and be used to prevent birth defect and can improve the compositions of remembering, it comprises as the Rhizoma Atractylodis Macrocephalae of active component and Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E.
The Rhizoma Atractylodis Macrocephalae is the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala koidz) rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and life usefulness or parching with earth, parched with bran are used.The used Rhizoma Atractylodis Macrocephalae of the present invention can be with its extract as raw material.
Be the tuber of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (L.f.) Ker-Gawl. Radix Ophiopogonis.Main product is in Zhejiang, Sichuan and other places.Excavate summer.This product feeble QI perfume (or spice), it is little sweet puckery to distinguish the flavor of, the toughness of chewing; The gentle person of, matter faint yellow, loose with the surface is good.Give birth to and use.The present invention used Radix Ophiopogonis can be with its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (FolicAcid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (Beta Carotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, and the effective dose of Radix Ophiopogonis extract is counted 300-12000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, and the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, also can improve memory to the prevention birth defect significant effect is arranged, sufficient raw, cost is low, and each component has no side effect in the compositions, no incompatibility, also can improve the memory except that the prevention birth defect, human body is still had the health care benefiting action.
Subordinate list 1 be this compositions with the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis component and the young rat/mouse labyrinth test effect of vitamin component relatively.
Subordinate list 2 be this compositions with the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis component and vitamin component Aged Mice maze test effect relatively.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 5:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Pantothenic acid 10mg,
Biotin 0.05mg,
Vitamin C 30mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: this composition and the bighead atractylodes rhizome and the tuber of dwarf lilyturf component and the young rat/mouse labyrinth test effect of vitamin component relatively:
| Group | Medicine | Consumption | Sample number | The mistake percentage |
| The A group | Control group | 0 | 12 | 21.6％ |
| The B group | The bighead atractylodes rhizome and the tuber of dwarf lilyturf are organized | The bighead atractylodes rhizome 100mg+ 50mg/ tuber of dwarf lilyturf days | 12 | 18.9％ |
| The C group | The vitamin group | VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 16.8％ |
| The D group | The bighead atractylodes rhizome and the tuber of dwarf lilyturf+the vitamin group | Bighead atractylodes rhizome 100mg+ 50mg+VB tuber of dwarf lilyturf60.08mg+VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 15.6％ |
Subordinate list 2: this composition and the bighead atractylodes rhizome and the tuber of dwarf lilyturf component and vitamin component Aged Mice maze test effect relatively:
| Group | Medicine | Consumption | Sample number | The mistake percentage |
| The A group | Control group | 0 | 12 | 53.3％ |
| The B group | The bighead atractylodes rhizome and the tuber of dwarf lilyturf are organized | The bighead atractylodes rhizome 100mg+ 50mg/ tuber of dwarf lilyturf days | 12 | 35％ |
| The C group | The vitamin group | VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 31.1％ |
| The D group | The bighead atractylodes rhizome and the tuber of dwarf lilyturf+the vitamin group | Bighead atractylodes rhizome 100mg+ 50mg+VB tuber of dwarf lilyturf60.08mg+VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 30.2％ |
Annotate: each group is fed to raise by dosage in the table respectively and was tested in 60 days in subordinate list 1, the subordinate list 2; Consumption in the table Convert by per kilogram of body weight.
Select 50 of newly-married healthy womens, 25 years old mean age, take continuously this group from beginning in pregnant front 3 months Compound was followed up a case by regular visits to none routine inborn defect in 6 months to the baby due. With the contrast of associated materials statistics, Fetal malformation accounts for the 4-6% of newborn population sum, and there were significant differences.
Can find out obviously that from table 1, table 2 this composition is by the bighead atractylodes rhizome group in rat/mouse labyrinth test and the composition Part and the contrast of vitamin added elements component, mistake percentage statistics, the function of this composition for improved memory Be better than bighead atractylodes rhizome component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (5)
1, a kind of being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
2, according to claim 1 being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
3, according to claim 1 being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 5-150mg a-TE.
4, according to claim 1 being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
5, according to claim 1 being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101150180A CN101342308A (en) | 2008-06-13 | 2008-06-13 | Medicament composition for preventing birth defect and improving memory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101150180A CN101342308A (en) | 2008-06-13 | 2008-06-13 | Medicament composition for preventing birth defect and improving memory |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101342308A true CN101342308A (en) | 2009-01-14 |
Family
ID=40244500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101150180A Pending CN101342308A (en) | 2008-06-13 | 2008-06-13 | Medicament composition for preventing birth defect and improving memory |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101342308A (en) |
-
2008
- 2008-06-13 CN CNA2008101150180A patent/CN101342308A/en active Pending
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Open date: 20090114 |