CN101391023A - Medicine composition for preventing the birth defect and improving the memory - Google Patents
Medicine composition for preventing the birth defect and improving the memory Download PDFInfo
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- CN101391023A CN101391023A CNA2008101150161A CN200810115016A CN101391023A CN 101391023 A CN101391023 A CN 101391023A CN A2008101150161 A CNA2008101150161 A CN A2008101150161A CN 200810115016 A CN200810115016 A CN 200810115016A CN 101391023 A CN101391023 A CN 101391023A
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Abstract
Disclosed is a medicine combination for preventing birth defect and improving memory, which includes Atractylodes macrocephaia, ophiopogon root, vitamin A, renieratene Beta, vitamin B complex, vitaminC, vitamin D, vitamin E, macroelement calcium and magnesium; the medicine combination is mainly applied to progestational women, pregnant women and wet nurses; the medicine combination has obvious effect for preventing birth defect and improving memory and has health care and nourishing functions at the same time, and even has no side effects for long time using.
Description
Technical field: the present invention relates to the Medicines and Health Product technical field.Also can improve the pharmaceutical composition of memory in particular for the prevention birth defect.
Background technology: birth defect is meant that fetus is in parent and in the organ formative process of birth back, by embryo due to the various factors effect and paedomorphosis disorder, comprise that morphosis is unusual, 4 types of physiological metabolism obstacle, congenital mental retardation and intrauterine growth retardations etc.Various countries' birth defect incidence rate is up to about 5% of the birth sum, and is great to the population quality influence, causes white elephant for family, society, become the common great public health problem of paying close attention in the present whole world.
The pathogenic factors of birth defect is very complicated, and inherited genetic factors is arranged, and environmental factors also has other multiple uncertain factor.Environmental factors comprises biological factor, physical factor, chemical factor; The embryo is subjected to the injury of environment harmful factor and other multiple uncertain factor, the birth defect sickness rate is increased, and eliminate these harmful factors, and the birth defect sickness rate is lowered.
Pharmaceutical composition of the present invention is a policy of following prenatal and postnatal care, by eliminating the birth defect factor that causes to the embryo, the generation of prevention birth defect reaches the purpose that lowers the birth defect sickness rate, simultaneously user there is the memory impairments of improvement, favourable mothers and sons two generations's health; Said composition comprises the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium.
The Rhizoma Atractylodis Macrocephalae is a kind of QI invigorating class natural Chinese medicine, and invigorating the spleen and benefiting QI is arranged, the dampness diuretic, the hidroschesis consolidating superficial resistance and in antiabortive effect; Ancient Chinese medicine is classified the Rhizoma Atractylodis Macrocephalae as on Chinese medicine product, antiabortive monarch drug, the panacea of fetus nourishing; The modern clinical cirrhotic ascites that are used for more, diarrhoea, Mo Niai syndrome, edema spontaneous perspiration, frequent fetal movement etc.; Modern pharmacological research confirms: 1, Rhizoma Atractylodis Macrocephalae Wheat Protein, can alleviate lipid peroxidation, and reduce the content of peroxide, avoid the destruction of harmful substance pair cell 26S Proteasome Structure and Function; And SOD activity improving trend is arranged, and enhancing body is to the ability of free radical scavenging, thus the damage of minimizing radical pair body.2, the Rhizoma Atractylodis Macrocephalae has delaying senility function, Rhizoma Atractylodis Macrocephalae decoct can improve the erythrocytic superoxide dismutase of aged mouse (SOD) activity, suppresses the brain activity of monoamine oxidase simultaneously, can also suppress erythrocytic autoxidation haemolysis, directly remove free radical, show anti-aging effects.3, the Rhizoma Atractylodis Macrocephalae has the enhance immunity effect, and oral lymhocyte transformation rate and the serum IgG content of making of Rhizoma Atractylodis Macrocephalae decoct significantly rises, and shows that the Rhizoma Atractylodis Macrocephalae has immunostimulation, and can strengthen the vigor of macrophage, strengthens the phagocytic function of reticuloendothelial system.4, anticancer tumor effect, Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to murine sarcoma S180, and external have direct killing action to the ehrlich ascites tumor cell, and external the Eca109 esophageal cancer cell is presented inhibition, can make cell detachment, karyopycnosis, chromatin concentrates, and cell does not divide or seldom division.5, the Rhizoma Atractylodis Macrocephalae also has the blood lipid-reducing blood sugar-decreasing effect, antibacterial action, and blood coagulation resisting function promotes the brood weight increase, physical potentiation raises to can be made leukocyte count by the leukopenia that causes after chemotherapy or the radiotherapy tumor.Traditional Chinese medical science custom in prescription the compatibility Rhizoma Atractylodis Macrocephalae with the absorption, particularly compatibility gold that promote the medicine active ingredient, stone class medicine to promote the absorption and the utilization of mineral.The Rhizoma Atractylodis Macrocephalae is the article that can be used for health food.
Be a kind ofly can nourishing lung-YIN be arranged, reinforcing stomach reg fluid, the relieving restlessness that clears away heart-fire, the effect of loosening bowel to relieve constipation as the nourishing YIN class natural Chinese medicine of health food Radix Ophiopogonis; Cure mainly deficiency of YIN chronic cough, interior-heat is quenched one's thirst, vexed insomnia, diseases such as dryness of the intestine constipation; Modern pharmacological research confirms to have Radix Ophiopogonis: 1, improve myocardial contraction and heart pump function; 2, the effect of protection cardiac muscle; 3, Antishock function; 4, oxygen lack resistant function; 5, remove the free radical effect; 6, anti-aging effects; 7, enhance immunity effect; 8, hypoglycemic activity; 9, accelerate the intestinal progradation; 10, antibacterial action etc.
Vitamin A also claims retinol, and the effect that improves vision, prevents nyctalopia is arranged, and the anemia of pregnant woman of enhancing Abwehrkraft des Koepers function is arranged, and can promote mucopolysaccharide synthetic, influences renewal, the growth of osseous tissue, and long bone is grown to both-end; If vitamin A deficiency is prone to premature labor or fetal congenital deformity.Beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B
1Have the effect of keeping the nervous system normal function, phenomenon such as it is incomplete to occur carbohydrate metabolism during shortage, and heat energy is under-supply, thus cause hypomnesis, influence the normal function of brain, if vitamin B
1Abundance can effectively form the energy of brain cell activity necessity, but improving memory, concentration power and learning capacity, vitamin B in addition
1Suppress cholinesterase in addition, improve the function of cholinergic nerve; Vitamin B
2Having another name called riboflavin, is the ingredient of many important coenzyme in the body, and it participates in intravital substance metabolism, promotes fetus and baby's growth promoter to play an important role vitamin B to the activity that earns a bare living
2Be to keep skin and the requisite vitamin of eye health, anemia of pregnant woman's vitamin B
2Lack or can not cause or inspire pregnant early pregnancy completely and vomit, second trimester angular cheilitis, glossitis, cheilitis and premature infant's incidence rate increase; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B
6Most important to the maincenter neurodevelopment, if shortage can make the nervus centralis hypoevolutism, intelligence descends, and it has the assistance vitamin B
1Effect, be the vitamin that can improve concentration power and stimulate desire learn; Vitamin B
12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B
12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.; Human body can be at vitamin B in addition
12Under the effect of folic acid as cofactors, by serine of taking in and the synthetic choline of methionine, choline is the key component of acetylcholine, and acetylcholine is an important neurotransmitter in the human body; Folic acid, vitamin B are arranged again
6And vitamin B
12Can work in coordination with and remove the intravital homotype cysteine of people, the homotype cysteine is a kind of neurotoxin, can cause the self murder of brain; There are some researches show that homocysteine is a kind of potential teratogen of independently growing, and is related closely with congenital heart disease and neural tube defects; Homocysteine also can cause miscarriage, premature labor in addition, clinical disastrous effect such as preeclampsia.
Vitamin C claims ascorbic acid again.Vitamin C and collagen in close relations, the vessel softening effect is not only arranged, the effect that purifies the blood in addition, prevent arteriosclerosis, can also promote the absorption of human body to ferrum in the food, for hemopoietic provides essential raw material, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious; Pregnancy duration, subcutaneous hemorrhage can appear in anemia of pregnant woman's hypovitaminosis C or deficiency, swelling and aching of gum, symptom such as bleed, fester, the long-term lacking vitamin C easily has virus flu, and increases the danger of fetus teratogenesis, and famine can cause miscarriage.
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation
3, ergosterol produces vitamin D behind ultraviolet radiation
2, the two originates different, the function unanimity, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption, the then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest.Have the effect of eliminating free radical, slow down aging, prevention maxicell hemolytic anemia, medically often adopting vitamin E treatment male and female infertility and threatened abortion; Vitamin E deficiency or anemia of pregnant woman's reproductive system is suffered damage, irreversible variation takes place in germinal epithelium, in addition, phenomenons such as maxicell hemolytic anemia and red blood cell life span shortening can take place also.
Calcium is the macroelement that body weight for humans is wanted, and mainly plays two aspects, the one, constitute sclerous tissueses such as bone tooth; The 2nd, constitute the material of specific function with protein bound or with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Anemia of pregnant woman and wet nurse's calcium deficiency can influence the growth of its body constitution and fetus or infant, and calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning, and anemia of pregnant woman and wet nurse are owing to physiological characteristics, the Deficiency of Intake of ubiquity calcium.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another function of magnesium is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis takes place magnesium deficiency easily, fractures easily; Magnesium is protected heart in addition and is prevented and treated the function etc. of diabetes in addition.
Application contains the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium has been known as the compositions of active component, but with the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium compatibility be used for prenatal and postnatal care prevention birth defect and can improve the pharmaceutical composition of remembering and report as yet.
Current medicine that is used to improve memory or health food kind have multiple, but aim at pregnant before the medicine or the health food that are used to improve memory of women, anemia of pregnant woman, wet nurse's development do not see as yet; Do not see the medicine label that is used to prevent birth defect as yet, rarely seen report that folic acid prevention neural tube defects is arranged; But its target spot is few, and the link shortcoming needs perfect.Do not see as yet and will prevent birth defect also can improve the effect of memory and be used for same medicine person.
Summary of the invention: in order to overcome existing prevention birth defect and/or to improve the shortcoming and defect of remembering medicine, the purpose of this invention is to provide a kind of compositions, said composition promotes the absorption and the utilization of vitamin, mineral by the Rhizoma Atractylodis Macrocephalae, and with collaborative vitamin A, beta-carotene, the vitamin B of increasing Radix Ophiopogonis
1, vitamin B
2, vitamin B
6, nicotiamide, pantothenic acid, biotin, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium improves the effect of memory and prevention birth defect, simultaneously by macroelement calcium, magnesium and vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen the antiabortive and Rhizoma Atractylodis Macrocephalae of Rhizoma Atractylodis Macrocephalae fetus nourishing and Radix Ophiopogonis effect such as defying age, anti-hypoxia, removing free radical, enhance immunity; Even chronic administration is also without any side effect.Because the result of broad research, the inventor have found the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium novel combination, this novel combination is for the prevention birth defect and can improve to remember synergy is arranged; And singly use the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium, its effect is all not as good as this compositions; And the effective ingredient of each component has the addition complementary action to the health care tonification of human body, as the Rhizoma Atractylodis Macrocephalae of the used dosage of this compositions have that fetus nourishing is antiabortive, the effect of defying age, enhance immunity, physical strength reinforcing; Nourishing lung-YIN, reinforcing stomach reg fluid are arranged Radix Ophiopogonis, clear away heart-fire and remove effect dry, loosening bowel to relieve constipation; Vitamin A has the raising vision, prevents the effect of nyctalopia; Vitamin B
1Can prevent and treat vitamin B1 deficiency, keep the normal activity of nerve, digestion, muscle, blood circulation; Vitamin B
2Be to keep skin and the requisite vitamin of eye health; Pellagra can take place in nicotinamide deficiency; The pantothenic acid shortage can cause Metabolic disorder; Biotin can be prevented and treated poliosis, alopecia; Vitamin B
6Can eliminate intraepithelial neoplasia cells, raise immunity, the protection blood vessel; Vitamin B
12Be used for various megaloblastic anemias and neural disease; Folic acid is protected heart and antitumaous effect in addition; Vitamin C has vessel softening, purifies the blood, prevents arteriosclerotic effect; Vitamin E has the free radical of removing, function in delaying senility; Macroelement calcium, magnesium and vitamin D are brought into play the effect of protection skeleton jointly.There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides and be used to prevent birth defect and can improve the compositions of remembering, it comprises as the Rhizoma Atractylodis Macrocephalae of active component and Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium.
The Rhizoma Atractylodis Macrocephalae is the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala koidz) rhizome.Main product in Zhejiang, ground such as Hubei, Hunan.Gather winter, dries or dry, and life usefulness or parching with earth, parched with bran are used.The used Rhizoma Atractylodis Macrocephalae of the present invention can be with its extract as raw material.
Be the tuber of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (L.f.) Ker-Gawl. Radix Ophiopogonis.Main product is in Zhejiang, Sichuan and other places.Excavate summer.This product feeble QI perfume (or spice), it is little sweet puckery to distinguish the flavor of, the toughness of chewing; The gentle person of, matter faint yellow, loose with the surface is good.Give birth to and use.The present invention used Radix Ophiopogonis can be with its extract as raw material.
Be used for vitamin B of the present invention
1(VitaminB
1), vitamin B
2(VitaminB
2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B
6(VitaminB
6), vitamin B
12(VitaminB
12), folic acid (FolicAcid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (Beta Carotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Calcium (Ca), magnesium (Mg) are the macroelements of needed by human; Macroelement calcium among the present invention can be selected calcium gluconate, calcium lactate, calcium carbonate etc. for use, and macroelement magnesium can be selected magnesium chloride, magnesium gluconate, magnesium lactate, magnesium carbonate etc. for use, and professional production factory and supplier are all arranged.
Compositions of the present invention mainly is applicable to women in pregnant early stage, anemia of pregnant woman and wet nurse; Be subjected to the influence of factors such as geology, food chain, dietetic life custom, the effective dose that the crowd that benefits from benefits from this compositions each component has certain difference; By the present invention, the effective dose of Rhizoma Atractylodis Macrocephalae extract is counted 500-15000mg/ days with whole crude drug, and the effective dose of Radix Ophiopogonis extract is counted 300-12000mg/ days with whole crude drug, vitamin B
1Effective dose be 0.5-20mg/ days, vitamin B
2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B
6Effective dose be 0.5-10mg/ days, vitamin B
12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, and the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, and the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, and the effective dose of macroelement calcium is 250-1000mg/ days, and the effective dose of magnesium is 100-300mg/ days.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, vitamin A, beta-carotene, vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, biotin, vitamin B
6, vitamin B
12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is eliminated the multiple factor that causes birth defect and cause hypomnesis from too many levels, multisystem, many target spots, the effect of collaborative performance effect is arranged between the each component, also can improve memory to the prevention birth defect significant effect is arranged, sufficient raw, cost is low, and each component has no side effect in the compositions, no incompatibility, also can improve the memory except that the prevention birth defect, human body is still had the health care benefiting action.
Subordinate list 1 be this compositions with the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis component and the young rat/mouse labyrinth test effect of vitamin added elements component relatively.
Subordinate list 2 be this compositions with the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis component and vitamin added elements component Aged Mice maze test effect relatively.
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules
Embodiment 4:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Embodiment 5:
Rhizoma Atractylodis Macrocephalae 2000mg,
Radix Ophiopogonis 500mg,
Folic acid 0.3mg,
Vitamin B
62mg,
Vitamin B
120.003mg,
Vitamin B
13mg,
Vitamin B
23mg,
Nicotiamide 10mg,
Pantothenic acid 10mg,
Biotin 0.05mg,
Vitamin C 30mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Retinol equivalent (vitamin A and/or beta-carotene) 300 μ g RE,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles.Obey every day 3 times, obey a bag at every turn.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Subordinate list 1: this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis component and the young rat/mouse labyrinth test effect of vitamin added elements component relatively:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 21.6％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis are organized | Rhizoma Atractylodis Macrocephalae 100mg+ 50mg/ Radix Ophiopogonis days | 12 | 18.9％ |
| The C group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 16.1％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ 50mg+ Radix Ophiopogonis calcium 10mg+ magnesium 5mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 15.6％ |
Subordinate list 2: this compositions and the Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis component and vitamin added elements component Aged Mice maze test effect relatively:
| Group | Medicine | Consumption | Sample number | The mistake percentage rate |
| The A group | Matched group | 0 | 12 | 53.3％ |
| The B group | The Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis are organized | Rhizoma Atractylodis Macrocephalae 100mg+ 50mg/ Radix Ophiopogonis days | 12 | 35％ |
| The C group | Vitamin+element set | Calcium 10mg+ magnesium 5mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 32.3％ |
| The D group | The Rhizoma Atractylodis Macrocephalae and Radix Ophiopogonis+vitamin+element set | Rhizoma Atractylodis Macrocephalae 100mg+ 50mg+ Radix Ophiopogonis calcium 10mg+ magnesium 5mg+VB 60.08mg +VB 120.0001mg+ folic acid 0.008mg/ days | 12 | 30.3％ |
Annotate: each group was tested by dosage feed in the table respectively in 60 days in subordinate list 1, the subordinate list 2; Consumption converts by per kilogram of body weight in the table; Calcium, magnesium are in element.
Select 50 of newly-married healthy womens, 25 years old mean age, take this compositions continuously from beginning in pregnant preceding 3 months, followed up a case by regular visits to none routine birth defect in 6 months to the baby due.With associated materials statistics contrasts, birth defect youngster account for the newborn population sum 4-6% there were significant differences.
Can obviously find out from table 1, table 2, this compositions is by Rhizoma Atractylodis Macrocephalae component in rat/mouse labyrinth test and the compositions and the contrast of vitamin added elements component, the statistical result of mistake percentage rate, the function of this composition for improved memory is better than Rhizoma Atractylodis Macrocephalae component or vitamin added elements component; With the blank group significant difference is arranged relatively.
Claims (5)
1, a kind of being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10-20mg,
Vitamin B
20-20mg,
Nicotiamide 0-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
2, according to claim 1 being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 0-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 0-150mg a-TE.
3, according to claim 1 being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotinoyl 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 5-150mg a-TE.
4, according to claim 1 being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
5, according to claim 1 being used to prevents birth defect and can improve the pharmaceutical composition of remembering, and it is characterized in that it is made by weight ratio by following raw materials according:
The Rhizoma Atractylodis Macrocephalae 500-15000mg,
Radix Ophiopogonis 300-12000mg,
Folic acid 0.1-1mg,
Vitamin B
60.5-10mg,
Vitamin B
120.001-0.025mg,
Vitamin B
10.5-20mg,
Vitamin B
20.5-20mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101150161A CN101391023A (en) | 2008-06-13 | 2008-06-13 | Medicine composition for preventing the birth defect and improving the memory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101150161A CN101391023A (en) | 2008-06-13 | 2008-06-13 | Medicine composition for preventing the birth defect and improving the memory |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101391023A true CN101391023A (en) | 2009-03-25 |
Family
ID=40491664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101150161A Pending CN101391023A (en) | 2008-06-13 | 2008-06-13 | Medicine composition for preventing the birth defect and improving the memory |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101391023A (en) |
-
2008
- 2008-06-13 CN CNA2008101150161A patent/CN101391023A/en active Pending
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