CN106039172A - Traditional Chinese medicine composition containing centella asiatica and capable of improving memory function and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition containing centella asiatica and capable of improving memory function and application of traditional Chinese medicine composition Download PDFInfo
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- CN106039172A CN106039172A CN201610528132.0A CN201610528132A CN106039172A CN 106039172 A CN106039172 A CN 106039172A CN 201610528132 A CN201610528132 A CN 201610528132A CN 106039172 A CN106039172 A CN 106039172A
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- chinese medicine
- medicine composition
- traditional chinese
- memory function
- herba centellae
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- 235000004032 Centella asiatica Nutrition 0.000 title abstract description 4
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition containing centella asiatica and capable of improving the memory function and application of the traditional Chinese medicine composition. According to the technical scheme, the traditional Chinese medicine composition is characterized by comprising, by weight, 10-30 parts of centella asiatica, 3-15 parts of longan pulp, 3-60 parts of oyster meat, 2-9 parts of fructus alpiniae oxyphyllae and 1-15 parts of ginseng. The traditional Chinese medicine composition can improve memory and is good in curative effect, safe and reliable, free of side effect and easy in raw material obtaining.
Description
Technical field
The present invention relates to field of medicaments, a kind of containing Herba Centellae have improve memory function Chinese medicine compound and
Its application.
Technical background
Learning and memory is the senior function of mankind central nervous system, be brain most basic be also most important senior god
Through one of function, it is to weigh the important indicator that human intelligence is grown.Memory is a kind of psychological process, is that people are to living through, sending out
The impression of the thing given birth to, preserves in the brain through processing, and extracts when needed, recalls out.Adult's memory is with the age
Increasing and change, this is a kind of physiological change, is the normal aging of a kind of memory.
Hypomnesis, the most especially crowd with 40～60 years old are the most common.Its main risk factor has age increases
Greatly, health total quality decline, senile dementia early symptom, mental work are excessively etc..In addition, memory is also good for body
Health situation is relevant, as the diseases such as brain tumor, diabetes, alcoholism, hypothyroidism, nerve syphilis all can cause
Hypomnesis.Memory and mental health also have highly important relation simultaneously, be chronically at that social pressure is big, depressed, feel oneself inferior,
Also dysmnesia can be caused during the mental statuss such as anxiety.
Distinguished veteran doctors of TCM expert through numerous studies find, hypomnesis belong to the traditional Chinese medical science " forgetful ", " forgetfulness ", " poor memory ",
The sick category such as " forgetting well ", the ancient prescription traditional Chinese medical science thinks forgetful and forgetfulness, is due to excessive thinking, nervous exhaustion, controls and preferably nourish heart kidney.Main
For " god's residence of people depends on kidney in the heart, the essence of the heart ", and the brain being the house of mentality, the sea of marrow, real memory institute with also.
In recent years being increasingly subject to pay attention on the research that animal learning memory function affects about Chinese medicine and extract thereof, experiment is ground
Study carefully and show that Chinese medicine goes down and has its unique distinction improving animal learning memory function.Use modem technology and method, from
In Chinese medicine, exploitation has and improves the product of learning and memory function and have good prospect.
Summary of the invention
It is an object of the invention to provide and a kind of improve the Chinese medicine composition of memory function containing having of Herba Centellae, it is controlled
Therapeutic effect is good.
For achieving the above object, the present invention adopts the following technical scheme that merit is remembered in a kind of improvement that has containing Herba Centellae
The Chinese medicine composition of energy, it is characterised in that formed by the traditional Chinese medicine of following weight ratio: Herba Centellae: Arillus Longan: Carnis ostreae: Fructus Alpiniae Oxyphyllae
Core: Radix Ginseng=(10-30): (3-15): (3-60): (2-9): (1-15).
Preferably, the traditional Chinese medicine of following weight ratio form: Herba Centellae: Arillus Longan: Carnis ostreae: Fructus Alpiniae Oxyphyllae: Radix Ginseng=
(10-20)∶(3-12)∶(3-30)∶(1-6)∶(1-6)。
Most preferably, the traditional Chinese medicine of following weight ratio form: Herba Centellae: Arillus Longan: Carnis ostreae: Fructus Alpiniae Oxyphyllae: Radix Ginseng
=15: 6: 15: 3: 2.
Described Chinese medicine composition is applied to prepare medicine or the health food improving memory function.
Described medicine or the dosage form of health food are decoction, oral liquid, syrup, capsule, tablet, granule or ball
Agent.
Described medicine or health food are that the extract of component, as effective ingredient, adds in described Traditional Chinese medicine composition formula
Add the preparation that pharmaceutic adjuvant prepares.
Described extract is water extract.
The present invention has the effect improving memory, and its therapeutic effect is good, safe and reliable, has no side effect, and uses Chinese medicine, raw material
It is easy to get.
Detailed description of the invention
The present invention is a kind of to improve the Chinese medicine composition of memory function, by following weight ratio containing having of Herba Centellae
Medicine is formulated: Herba Centellae: Arillus Longan: Carnis ostreae: Fructus Alpiniae Oxyphyllae: Radix Ginseng=(10-30): (3-15): (3-60): (2-9): (1-
15).Preferably, the traditional Chinese medicine of following weight ratio form: Herba Centellae: Arillus Longan: Carnis ostreae: Fructus Alpiniae Oxyphyllae: Radix Ginseng=(10-
20)∶(3-12)∶(3-30)∶(1-6)∶(1-6).Most preferably, the traditional Chinese medicine of following weight ratio form: Herba Centellae: Arillus Longan
Meat: Carnis ostreae: Fructus Alpiniae Oxyphyllae: Radix Ginseng=15: 6: 15: 3: 2.Described Chinese medicine composition is applied to prepare the medicine improving memory function
Or health food.
This medicine or health food can be decoction.Or, the convenience taken for patient and the characteristic according to extract,
Can make preparation, in described Traditional Chinese medicine composition formula, the extract of component is as effective ingredient, adds corresponding pharmaceutic adjuvant, presses
It is prepared as any oral formulations according to Chinese medicine conventional formulation technique.The dosage form of preparation can be oral liquid, syrup, capsule
Agent, tablet, dissolved granule, pill etc..Wherein extract is preferably water extract, can prepare, such as by extraction process by water routinely: take
The medical material of formula mixes according to monarch prescription ratio, every time with the water of 8～12 times of medical material deals, soaks post-heating backflow and carries
Take 1～3 hour, extract 1～3 time, filter, merging filtrate, be concentrated to every milliliter contained 0.5～5.0g, to obtain final product.Again to extraction
Thing adds corresponding pharmaceutic adjuvant can be prepared as any oral formulations.
Chinese medicine used in the present invention has the feature that
Herba Centellae: for the dry herb of samphire Herba Centellae Centella asiatica (L.) Urb..It is bitter, pungent,
Cold.There is clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling, it is usually used in jaundice due to damp-heat, heatstroke is suffered from diarrhoea, stranguria caused by urinary stone stranguria with blood, and carbuncle sore tumefacting virus falls and flutters
Damage." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controlling meridian hectic fever, dizziness, be afraid of cold, limbs are aching and tired, poor appetite, and man's woman child's infantile malnutrition, deficient fever does not moves back
Person with it, diuresis, buffalo meat is for drawing.”
Arillus Longan: for the aril of sapindaceous plant Arillus Longan Dimocarpus longan Lour..There is the tonification heart
Spleen, effect of nourishing blood to tranquillize the mind.It is usually used in insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion." book on Chinese herbal medicine is looked for the truth ": " Arillus Longan
More the sweet temperature of abnormal smells from the patient, have and be similar to Fructus Jujubae, but this sugariness is heavier, and profit gas is the most, among QI invigorating, the most more has the power enriched blood, therefore book
Carry can the long intelligence of strengthening the spleen, nourish heart guarantor's blood, for heart spleen key medicine, is to see forgetful, palpitation with a distress feeling, palpitation with fear, and discharging fresh blood stool with thought impairment caused by overstrain, all
Available this for controlling ".
Carnis ostreae: for Ostreidae animal long Concha Ostreae Ostrea gigas Thunberg, Dalian Bay Concha Ostreae Ostrea
Talien whanensis Crosse or the dry software part of Crassostrea rivularis Ostrea rivularis Gould.Sweet, salty,
Flat.Return liver, gallbladder, kidney channel.Function nourishing YIN and benefiting blood.Have a sleepless night for dysphoria with smothery sensation, irritability, erysipelas.Supplement to the Herbal: cook, main void
Damage, married woman's vim and vigour, in tune, solve erysipelas.It is eaten raw in ginger vinegar, main erysipelas, after drinking dysphoria with smothery sensation, quench the thirst.
Fructus Alpiniae Oxyphyllae: for the dry mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae Alpinia oxyphylla Miq..Acrid in the mouth, warm in nature,
Enter the heart, spleen, kidney channel.Function the kidney warming controlling nocturnal emission with astringent drugs reducing urination, saliva is taken the photograph in warming the spleen appetizing.Cure mainly spleen-kidney vacuity cold, abdominal pain diarrhea；Or kidney qi deficiency and coldness is little
Just frequency, the enuresis, seminal emission, nebulousurine；Or in chronic diarrhea caused by Deficiency and coldness of spleen and stomach and mouth saliva outflow and can not effector.Fructus Alpiniae Oxyphyllae
Core is containing volatile oil, Fructus Alpiniae Oxyphyllae ketone, vitamin B1, vitamin B2, vitamin C, vitamin E and several amino acids, fatty acid etc..Benefit
Intelligence core decoct has stomach invigorating, diuresis, the effect of minimizing salivation.Its water extract has suppression ascitogenous sarcoma S180 cell
The effect increased.Its water extract and ethanol extraction have the effect of suppression ileum contraction.Additionally, its methanolic extract has enhancing
The effects such as the activity exempting from aorta contraction and suppression prostaglandin synthetase that left atrium contracts power, suppression potassium chloride cause.
Radix Ginseng: the dry root of Araliaceae Radix Ginseng PanaxginsengC.A.Mey. and rhizome.Hardship sweet, micro-, tepor.Return
Spleen, lung, the heart, kidney channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid and nourishes blood, Fructus Alpiniae Oxyphyllae of calming the nerves.For weak body and prostration, cold extremities
Faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung breathes with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, and prolonged illness void is won, palpitation with fear insomnia, sexual impotence cold womb.
" property of medicine opinion ": " main the five internal organs QI-insufficiency, five kinds of strain and seven kinds of impairment, deficient thin and weak, tell inverse lower food, only cholera unhappiness is vomitted the sound of vomiting, tonifying five ZANG-organs six
Internal organs, keeps god in guarantor." " disappears expectorant in the heart, main consumptive lung disease vomiting pus and epilepsy disease, and cold air is against upper, and the lower food of typhoid fever, suffers from that people is empty and dreaminess is diverse and confused,
Add and use it."
Take a broad view of full side, Herba Centellae clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling；Carnis ostreae nourishing YIN and benefiting blood.Both are monarch drug altogether.The big benefit of Radix Ginseng
Vigour, promotes the production of body fluid and nourishes blood, Fructus Alpiniae Oxyphyllae of calming the nerves.For ministerial drug.Arillus Longan invigorating the heart and spleen, nourishing blood to tranquillize the mind, for adjuvant drug；Fructus Alpiniae Oxyphyllae the kidney warming controlling nocturnal emission with astringent drugs contracts
Urine, warming the spleen appetizing takes the photograph saliva for making medicine.Full side plays heat clearing away YIN nourishing, blood-enriching tranquillizing effect altogether.
Below in conjunction with embodiment, the present invention is further illustrated, but the present invention is not limited to this specific examples:
Embodiment 1
Take Herba Centellae 150g, Arillus Longan 60g, Carnis ostreae 150g, Fructus Alpiniae Oxyphyllae 30g, Radix Ginseng 20g, add 10 times amount water, soak 30
Minute, reflux, extract, 1.5 hours, extract 2 times, filter, merging filtrate, be concentrated into 250ml, obtain decoction.
Embodiment 2
Take Herba Centellae 300g, Arillus Longan 60g, Carnis ostreae 30g, Fructus Alpiniae Oxyphyllae 90g, Radix Ginseng 10g, add 10 times amount water, soak 30
Minute, reflux, extract, 1.5 hours, extract 2 times, filter, merging filtrate, be concentrated into 250ml, obtain decoction.
Embodiment 3
Herba Centellae 150g, Arillus Longan 90g, Carnis ostreae 200g, Fructus Alpiniae Oxyphyllae 30g, Radix Ginseng 50g, add 10 times amount water, soaks 45 points
Clock, reflux, extract, 2 hours, extract 3 times, filter, merging filtrate, be concentrated into 250ml, obtain decoction.
Embodiment 4
Taking above-described embodiment 1 gained decoction, add 10 times amount water, agitating heating is boiled, and boils 20 minutes, to be cooled to 30
～when 40 DEG C, add appropriate chitosan and potassium sorbate, be stirred to dissolve uniformly, filter, finally add pure water adjust to
1000ml, filters, subpackage, sterilizing, obtains oral liquid.Every oral liquid 10ml.
Embodiment 5
Take above-described embodiment 1 gained decoction, separately take sucrose 600g and make simple syrup, treat that syrup temp is down to less than 60 DEG C,
Add embodiment 1 decoction stir evenly with ethyl hydroxybenzoate 0.lg, vanilla 2ml, filtration, add from filter pure water adjust to
1000ml, mixing, subpackage, sterilizing, obtain syrup.Every 100ml.
Embodiment 6
Take above-described embodiment 1 gained decoction, concentrate, be dried, obtain dry extract；Take dry extract 25.8g, be ground into fine powder, add
Enter appropriate medical starch and micropowder silica gel, mixing, cross 14 mesh sieves and pelletize, 65 DEG C are dried, carry out granulate after 14 mesh sieves,
It is subsequently adding appropriate magnesium stearate, mixing, it is pressed into 100, obtains tablet.Every tablet weight 0.45g.
Embodiment 7
Take above-described embodiment 1 gained decoction, concentrate, be dried, obtain dry extract；Take dry extract 14g, be ground into fine powder, add
Appropriate medical starch and magnesium stearate, mix homogeneously, sieves, loads capsule, make 100, obtain hard capsule.Every intragranular holds
Thing weight 0.25g.
Embodiment 8
Take above-described embodiment 1 gained decoction, concentrate, be dried, obtain dry extract；Take dry extract 25.6g, be ground into fine powder, add
Enter appropriate dextrin and lactose, mixing, pelletize, 65 DEG C are dried, and cross 14 mesh sieves and carry out granulate, and subpackage prepares 100 bags, obtain
Granule.Often bag weight 4.5g.
Embodiment 9
Take above-described embodiment 1 gained decoction, concentrate, be dried, obtain dry extract；Take dry extract 26.8g, be ground into fine powder,
Sieve, mixing, with water pill, prepare 100, obtain pill, every weight 1.45g.
Experimental example: improve the little experiment of memory function
1. experiment material
Kunming SPF level male mice 78, body weight 23-28g, Nanfang Medical Univ's Experimental Animal Center provide.Qualified
Card number: SCXK (Guangdong) 2011-0015.Test medicine uses decoction prepared by embodiment 1 quantitatively to prepare.Morris water maze
Experimental system (includes Morris water maze, computer camera system, software kit analyzes system).
2. experimental technique
2.1 packets and administration
78 mices are randomly divided into three groups, respectively high dose group, low dose group, blank group, often group 26；High dose
Group dosage is 14.90g/kg (crude drug amount/every kg animal weight), and low dose group dosage is 5.96g/kg (crude drug amount/every
Kg animal weight), it is administered in gavage mode, once a day, continuous 22 days, blank group gave equal-volume normal saline.
2.2Morris water maze laboratory
Morris water maze is divided into 4 quadrants, the sky blue platform of a diameter of 10cm is placed in the fourth quadrant of pond, water
Pond diameter about 1 meter, the inside is higher than platform 1-2cm equipped with ink, the water surface.Pond photographic head installed above also connects computer, from
Dynamic collection animal swimming trace image also automatically analyzes and processes, and record mice finds the time (escape latency) of platform.If
Mice does not finds platform in 60s, then caused platform and stop 10s, and escape latency is designated as 60s, Therapy lasted 6d time.
Calculate every mice respectively and enter the average escape latency of water every day from four quadrants, using its meansigma methods as little
The escape latency of this day of Mus, then calculate blank group with excel respectively, low dose group, the escape of high dose group mice every day is dived
The meansigma methods of volt phase and variance, result represents with x ± s, as shown in table 1.
The impact (x ± s, n=26) on ability of learning and memory in mice of table 1 Experimental agents
Note: * represents significant difference (P ＜ 0.05) compared with blank group.
By table 1 result all in all, the escape latency of each group mice shortens the most day by day, illustrates that mice has study
The ability of memory；From first day to the 6th day, the escape plateau of each group mice, was essentially all blank group > low dose group > high
Dosage group, wherein plays high dose group on the 3rd day and compares with blank group and have significant difference, point out medicine of the present invention to have improvement to learn
The effect of memory ability, and high dose effect is more notable.
Claims (7)
1. one kind containing Herba Centellae there is the Chinese medicine composition improving memory function, it is characterised in that by following weight ratio
Medicine is formulated: Herba Centellae: Arillus Longan: Carnis ostreae: Fructus Alpiniae Oxyphyllae: Radix Ginseng=(10-30): (3-15): (3-60): (2-9): (1-
15)。
The most according to claim 1 improve the Chinese medicine composition of memory function containing having of Herba Centellae, it is characterised in that
Formed by the traditional Chinese medicine of following weight ratio: Herba Centellae: Arillus Longan: Carnis ostreae: Fructus Alpiniae Oxyphyllae: Radix Ginseng=(10-20): (3-12):
(3-30)∶(1-6)∶(1-6)。
The most according to claim 1 improve the Chinese medicine composition of memory function containing having of Herba Centellae, it is characterised in that
Formed by the traditional Chinese medicine of following weight ratio: Herba Centellae: Arillus Longan: Carnis ostreae: Fructus Alpiniae Oxyphyllae: Radix Ginseng=15: 6: 15: 3: 2.
4. Chinese medicine composition described in claim 1-3 any claim is applied to prepare medicine or the health care improving memory function
Food.
The most according to claim 4, Chinese medicine composition is applied to prepare medicine or the health food improving memory function, and it is special
Levy and be: described medicine or the dosage form of health food are decoction, oral liquid, syrup, capsule, tablet, granule or ball
Agent.
The most according to claim 4, Chinese medicine composition is applied to prepare medicine or the health food improving memory function, and it is special
Levy and be: described medicine or health food are that the extract of component, as effective ingredient, adds in described Traditional Chinese medicine composition formula
Add the preparation that pharmaceutic adjuvant prepares.
The most according to claim 6, Chinese medicine composition is applied to prepare medicine or the health food improving memory function, and it is special
Levy and be: described extract is water extract.
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