CN109481656A - A kind of drug for treating senile dementia - Google Patents
A kind of drug for treating senile dementia Download PDFInfo
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Abstract
Be as made from the raw material of following parts by weight the invention discloses a kind of drug for treating senile dementia: 15-25 parts of Radix Astragali, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of radix aconiti lateralis preparata, 15-20 parts of Uncinata Spikemoss Herb, 10-20 parts of fructus viticis, 12-16 parts of smallflower galinsoga herb, 5-10 parts of rhizoma zingiberis, 3-8 parts of folium photiniae, 10-15 parts of fructus lycii, 8-12 parts of Sword Jackbean Seed, 6-10 parts of Chinese knotweed herb, fries jujube nucleus 10-16 parts at 10-15 parts of waxgourd seed.The present invention is pure Chinese medicinal preparation, and for senile dementia etiology and pathogenesis, ingredients respectively has its effect, coordinate mutually, follow strengthening vital QI to eliminate pathogenic factors, the principle of reatment for the treatment of both manifestation and root cause of disease, all medicines share, warming kidney and strengthening spleen, invigorating qi for strengthening superficies, effect promoting blood circulation and removing obstruction in channels are played altogether, there is excellent therapeutic effect to senile dementia, cure rate is high, has no toxic side effect, it does not recur, is effectively treated senile dementia.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of drug for treating senile dementia.
Background technique
Dementia is common disease of old people, and the difficult treatment that current the world of medicine is generally acknowledged, according to World Health Organization, 65 years old
In above the elderly, there is 10% people that obstacle intelligently occurs, and wherein 60% human hair is raw dull-witted, and with the increasing at age
Height, dementia incidence are in the trend of substantial increase.Senile dementia means the various chronic brain syndromes occurred in the senescence phase,
Including Alzheimer disease (AD), vascular dementia (VD), Mixed dementia (AD+VD) and other dementias.First two is old age
Property dull-witted main Types, account for 90% or more of all dementias.AD is a kind of retrogression pathological changes with brain, and brain cell atrophy is it
The dull-witted syndrome of pathologic basis.And VD is mostly caused by ischemic, hemorrhagic cerebrovascular disease and hypoxia-induced cerebrovascular disease.
Mixed dementia (AD+VD) is common in old dementia patients, and the pathology of the two, symptom and neurobiochemistry feature are often mutual
Be overlapping, people had once done many work and have gone to identify AD and VD, but with the continuous deepening of research, similitude between the two and
The two may plyability in itself increasingly paid attention to by people.They clinically show as because of cognitive decrease
Caused decrease of memory, behavior is slow, exercise not harmony.Its main pathological characters is that intracerebral a large amount of senile plaques, nerve occurs
Fibre matting, beta-amyloid protein deposition and neuron vacuolar degeneration and a large amount of forfeitures.
Traditional Chinese medicine by senile dementia be included into " demented ", " melancholia ", " dementia " scope, it is believed that its sick position is in brain, and people is extremely
Old age, kidney essence deficiency, brain become homeless it is feeding, it is then raw dull-witted.The channels of brains is a part of whole body channels, its physiology, pathology changes
Becoming the variation with whole body channels has something in common, but has distinguishingly pathological change because occupying unique status.Tang's SUN Si miao
" Qianjin Yao Fang moxibustion therapy door " cloud: " head person, the head of body, people's mind are infused, and port is astute, 365 networks all on be attributed to
Head." brain is to spoil the dirty, house of mental activity, the ground of spirit, the source of refreshing machine, the blood of the five internal organs essence, six internal organs are clear positive depressed to converge at brain.
The member divine tool of brain has the function of commander's the five internal organs mind.In addition, traditional Chinese medicine thinks the spirit and consciousness activity of people, though the five internal organs can be belonged to,
But Master Home is in the physiological function that The heart controls mental activities.
Since senile dementia pathology change procedure is considerably complicated, it is related to multisystem, the exception of multiple target point, although the world
Various countries have put into a large amount of man power and material in the research for finding the effective therapeutic agent of senile dementia, but achievement extremely has
Limit.
Summary of the invention
The present invention provides a kind of good effect, cure rate height, the drugs for treating senile dementia having no toxic side effect.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of drug for treating senile dementia is as made from the raw material of following parts by weight: 15-25 parts of Radix Astragali, waxgourd seed
10-15 parts, it is 8-12 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of radix aconiti lateralis preparata, 15-20 parts of Uncinata Spikemoss Herb, 10-20 parts of fructus viticis, 12-16 parts of smallflower galinsoga herb, dry
5-10 parts of ginger, 3-8 parts of folium photiniae, 10-15 parts of fructus lycii, 8-12 parts of Sword Jackbean Seed, 6-10 parts of Chinese knotweed herb, 8-12 parts of Ficus lyrata,
Fry jujube nucleus 10-16 parts.
Preferably, a kind of drug for treating senile dementia is as made from the raw material of following parts by weight: 18-22 parts of Radix Astragali,
11-13 parts of waxgourd seed, 9-11 parts of Rhizoma Atractylodis Macrocephalae, 11-13 parts of radix aconiti lateralis preparata, 17-19 parts of Uncinata Spikemoss Herb, 13-18 parts of fructus viticis, smallflower galinsoga herb 13-
15 parts, 6-9 parts of rhizoma zingiberis, 4-6 parts of folium photiniae, 11-13 parts of fructus lycii, 9-11 parts of Sword Jackbean Seed, 7-9 parts of Chinese knotweed herb, Ficus lyrata 9-
11 parts, jujube nucleus 12-14 parts of stir-fry.
It is furthermore preferred that a kind of drug for treating senile dementia, is as made from the raw material of following parts by weight: 20 parts of Radix Astragali,
12 parts of waxgourd seed, 10 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of radix aconiti lateralis preparata, 18 parts of Uncinata Spikemoss Herb, 15 parts of fructus viticis, 14 parts of smallflower galinsoga herb, 7 parts of rhizoma zingiberis, Chinese photinia
5 portions of leaf, 10 parts of Sword Jackbean Seed, 8 parts of Chinese knotweed herb, 10 parts of Ficus lyrata, fries 13 parts of jujube nucleus at 12 parts of fructus lycii.
The present invention treats the preparation method of the drug of senile dementia, is prepared by the following steps to obtain:
Formula ratio raw medicinal material is taken, appropriate chopping or crushing, setting is suitable for decocting in container, adds 1500-2000ml water immersion
Medicinal material, impregnate 1.5 hours after, be heated to boiling, then separate fried liquid after decocting 30 minutes, added in the dregs of a decoction 1000ml water according to
Method is 2-3 times fried again, and after collecting each fried liquid and mixing after being centrifugated or settling filtration, low temperature is concentrated into opposite at 85 DEG C
Density is the paste of 1.30-1.35.Suitable conventional pharmaceutical adjuvants are added into above-mentioned thick paste, are filled after whole grain, dry disinfection
Enter in capsule shells, every capsule weight 0.5g.
Usage and dosage: it is oral, three times per day, one time 4.20 days are 1 course for the treatment of, and the general 2-4 course for the treatment of can cure.
The pharmacology of each bulk pharmaceutical chemicals is as follows:
Radix Astragali: sweet in flavor, slightly warm in nature.Return lung, spleen, liver and kidney channel.Tonifying Qi and lifting yang, invigorating qi for consolidating superficies.Modern medicine study shows:
Radix Astragali has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial action.It can eliminate
Experimental nephritis proteinuria enhances myocardial contractive power, adjusts blood-sugar content.Radix Astragali can not only coronary artery dilator, improve cardiac muscle
Blood supply improves immune function, and is capable of the process of delaying cell aging.
Waxgourd seed: it is cold in nature, it is sweet in flavor.Clearing lung and eliminating phlegm, the carbuncle that disappears apocenosis.For cough with lung heat, pulmonary abscess, acute appendicitis from the beginning of.
Rhizoma Atractylodis Macrocephalae: it is bitter, sweet, it is warm-natured.Returns spleen, stomach meridian.It invigorates the spleen and benefits qi, eliminate dampness and have diuretic effect, it acts as: stomach invigorating is aid digestion, right
Preventing or arresting vomiting antidiarrheal has certain effect, but need to often match Chinese digestant drugs for removing food accumulation or damp-clearing drug；Diuresis is more apparent and lasting, it may be possible to due to
Reabsorption function is resisted, the excretion of sodium is increased；Contained volatile oil has sedation in a small amount.In addition, clinical observation Rhizoma Atractylodis Macrocephalae
The effects of there are also hidroschesis, nourishing.
Radix aconiti lateralis preparata: acrid flavour, sweet, extremely hot in nature.Recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.It collapses for yang depletion, limb cold
Weak pulse, impotence, palace cold, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.
Uncinata Spikemoss Herb: it is sweet in flavor, light, it is cool in nature.Clearing heat and promoting diuresis, hemostasis, cough-relieving.For enteritis, dysentery, nephritic dropsy, urinary system
Infection, rheumatic arthritis, hemoptysis of pulmonary tuberculosis.
Fructus viticis: cold nature, acrid flavour, hardship.Dispelling wind and heat from the body, head clearing.It has a headache for anemopyretic cold, gingivitis, mesh
Red more tears, mesh is secretly unknown, has a dizzy spell.
Smallflower galinsoga herb: it is lightly seasoned, it is mild-natured.Anti-inflammatory, hemostasis.Treating tonsillitis, sphagitis, acute icteric hepatitis, traumatic hemorrhage.
Rhizoma zingiberis: warm spleen sun helps water-wet transporting, warming yang for resolving fluid retention.
Folium photiniae: mild-natured, acrid flavour, hardship.Wind-dispelling, dredging collateral, kidney-nourishing.For wind-warm syndrome numbness pain, aching pain in waist and back, the foot and knee being feeble, partially
Headache.
Fructus lycii: it is mild-natured, it is sweet in flavor.Nourishing the liver, nourshing kidney, moistening lung.For caused by liver and kidney deficiency, have a dizzy spell, visually unclear, waist and knee acid
Soft, cough due to consumptive disease quenches one's thirst and draws drink.
Sword Jackbean Seed: it is sweet in flavor, it is warm-natured, nontoxic.Returns spleen, stomach, large intestine, kidney channel.Middle benefit gas, lower gas, only oh, kidney-nourishing complement.For
Deficiency-cold in spleen and stomach, hiccup, vomiting, abdominal distension, diarrhea, kidney deficiency, pain in the loins, defect inflatable pain, timid cold limb cold, pale complexion, phlegm asthma.
Chinese knotweed herb: acrid flavour, hardship, it is cool in nature.Clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, calming the liver and improving eyesight are activated blood and relaxed tendons.For dysentery, let out
It rushes down, abscess of throat, diphtheria, cough with lung heat, pertussis, hepatitis, leukorrhagia, cancerous swelling, tympanitis, eczema, dizziness and tinnitus, cornea cloud
Screen, traumatic injury.
Ficus lyrata: it is sweet in flavor, pungent, it is warm-natured.The promoting flow of qi and blood circulation, relaxing tendons and activating collaterals, menstruation regulating.For aching pain in waist and back, traumatic injury, cream
Carbuncle, dysmenorrhea, malaria.
Fry jujube nucleus: it is sweet in flavor, it is mild-natured.Return heart, spleen, liver, gallbladder channel.Antitoxic heart-soothing and sedative, nourishing the liver, arrest sweating.For restlessness of asrhenia type and insomnia, shy
Throb with fear palpitation, physically weak spontaneous perspiration, night sweat.
In the present invention, Radix Astragali and Sword Jackbean Seed are monarch, and the two cooperation, tonifying Qi and lifting yang, invigorating qi for consolidating superficies, kidney and spleen invigorating can bushings
The gas of spleen, and QI invigorating, with blood-nourishing, beneficial will of calming the nerves improves immunity, expands blood vessel, inhibit platelet aggregation, reduces blood viscosity,
Improve the perfusion flow of blood circulation and brain, and then improves corticocerebral excited, process of inhibition.Waxgourd seed, Rhizoma Atractylodis Macrocephalae and Uncinata Spikemoss Herb
For minister, clearing heat and promoting diuresis, dissipating phlegm for resuscitation, and principal drug assistance is invigorated the spleen and benefited qi, and local blood circulation is increased, reach platelet aggregation-against and
Thrombolytic effect, reduces myocardial oxygen consumption and coefficient of oxygen utilization, and expansion of cerebral vascular promotes brain cell metabolism.Radix aconiti lateralis preparata, is done fructus viticis
Ginger, fructus lycii and stir-fry jujube nucleus are assistant, and warming yang for resolving fluid retention, calming the heart and calming the nerves, nourishing the liver warm kidney moisten blood vessels, qualcomm meridian, harmonizing the functional activities of vital QI, drop
Low brain tissue cholinesterase activity inhibits accumulation of the aluminium ion in brain tissue, and then improves memory disorders.Smallflower galinsoga herb, Chinese photinia
Leaf, Chinese knotweed herb and Ficus lyrata are to make, activating microcirculation and removing stasis medicinal dredging collateral, promoting the circulation of qi relaxing muscles and tendons kidney-nourishing, reach hemostasis and do not stay the stasis of blood, stagnation resolvation is not hurt positive
Effect improves the protective effect to nerve cell, and nervous system is promoted to restore.
Beneficial effects of the present invention: the present invention is pure Chinese medicinal preparation, and for senile dementia etiology and pathogenesis, ingredients is each
Have its effect, coordinate mutually, it then follows it is solid to play warming kidney and strengthening spleen, tonifying Qi altogether for strengthening vital QI to eliminate pathogenic factors, the principle of reatment for the treatment of both manifestation and root cause of disease, all medicines share
Table, effect promoting blood circulation and removing obstruction in channels have excellent therapeutic effect to senile dementia, and cure rate is high, has no toxic side effect, does not recur, makes
Senile dementia is effectively treated.
Specific embodiment
It elaborates below to the present invention, to enable those of ordinary skill in the art refering to can be real accordingly after this specification
It applies.
Embodiment 1
A kind of drug for treating senile dementia is as made from the raw material of following parts by weight: 15 parts of Radix Astragali, waxgourd seed 15
Part, 12 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of radix aconiti lateralis preparata, 20 parts of Uncinata Spikemoss Herb, 10 parts of fructus viticis, 12 parts of smallflower galinsoga herb, 10 parts of rhizoma zingiberis, 3 parts of folium photiniae, Chinese holly
15 parts of matrimony vine, 10 parts of Chinese knotweed herb, 8 parts of Ficus lyrata, fries 16 parts of jujube nucleus at 8 parts of Sword Jackbean Seed.
The present embodiment treats the preparation method of the drug of senile dementia, is prepared by the following steps to obtain: taking formula ratio
Raw medicinal material, appropriate chopping or crushing, setting is suitable for decocting in container, adds 2000ml water immersion medicinal material, after impregnating 1.5 hours, is added
Heat then separates fried liquid after decocting 30 minutes to boiling, and adds 1000ml water again fried 2 times in accordance with the law in the dregs of a decoction, collects each decoct
Out liquid and mix after after being centrifugated or settling filtration, when low temperature is concentrated into 85 DEG C relative density be 1.35 paste.To
Suitable conventional pharmaceutical adjuvants are added in above-mentioned thick paste, are fitted into capsule shells after whole grain, dry disinfection, every capsule weight 0.5g.
Embodiment 2
A kind of drug for treating senile dementia is as made from the raw material of following parts by weight: 18 parts of Radix Astragali, waxgourd seed 13
Part, 11 parts of Rhizoma Atractylodis Macrocephalae, 11 parts of radix aconiti lateralis preparata, 19 parts of Uncinata Spikemoss Herb, 13 parts of fructus viticis, 13 parts of smallflower galinsoga herb, 9 parts of rhizoma zingiberis, 4 parts of folium photiniae, Chinese holly
13 parts of matrimony vine, 9 parts of Chinese knotweed herb, 9 parts of Ficus lyrata, fries 14 parts of jujube nucleus at 9 parts of Sword Jackbean Seed.
The present embodiment treats the preparation method of the drug of senile dementia, is prepared by the following steps to obtain: taking formula ratio
Raw medicinal material, appropriate chopping or crushing, setting is suitable for decocting in container, adds 1800ml water immersion medicinal material, after impregnating 1.5 hours, is added
Heat then separates fried liquid after decocting 30 minutes to boiling, and adds 1000ml water again fried 3 times in accordance with the law in the dregs of a decoction, collects each decoct
Out liquid and mix after after being centrifugated or settling filtration, when low temperature is concentrated into 85 DEG C relative density be 1.30 paste.To
Suitable conventional pharmaceutical adjuvants are added in above-mentioned thick paste, are fitted into capsule shells after whole grain, dry disinfection, every capsule weight 0.5g.
Embodiment 3
A kind of drug for treating senile dementia is as made from the raw material of following parts by weight: 20 parts of Radix Astragali, waxgourd seed 12
Part, 10 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of radix aconiti lateralis preparata, 18 parts of Uncinata Spikemoss Herb, 15 parts of fructus viticis, 14 parts of smallflower galinsoga herb, 7 parts of rhizoma zingiberis, 5 parts of folium photiniae, Chinese holly
12 parts of matrimony vine, 8 parts of Chinese knotweed herb, 10 parts of Ficus lyrata, fries 13 parts of jujube nucleus at 10 parts of Sword Jackbean Seed.
The present embodiment treats the preparation method of the drug of senile dementia, is prepared by the following steps to obtain: taking formula ratio
Raw medicinal material, appropriate chopping or crushing, setting is suitable for decocting in container, adds 1800ml water immersion medicinal material, after impregnating 1.5 hours, is added
Heat then separates fried liquid after decocting 30 minutes to boiling, and adds 1000ml water again fried 3 times in accordance with the law in the dregs of a decoction, collects each decoct
Out liquid and mix after after being centrifugated or settling filtration, when low temperature is concentrated into 85 DEG C relative density be 1.35 paste.To
Suitable conventional pharmaceutical adjuvants are added in above-mentioned thick paste, are fitted into capsule shells after whole grain, dry disinfection, every capsule weight 0.5g.
Embodiment 4
A kind of drug for treating senile dementia is as made from the raw material of following parts by weight: 22 parts of Radix Astragali, waxgourd seed 11
Part, 9 parts of Rhizoma Atractylodis Macrocephalae, 13 parts of radix aconiti lateralis preparata, 17 parts of Uncinata Spikemoss Herb, 18 parts of fructus viticis, 15 parts of smallflower galinsoga herb, 6 parts of rhizoma zingiberis, 6 parts of folium photiniae, fructus lycii
11 parts of son, 7 parts of Chinese knotweed herb, 11 parts of Ficus lyrata, fries 12 parts of jujube nucleus at 11 parts of Sword Jackbean Seed.
The present embodiment treats the preparation method of the drug of senile dementia, is prepared by the following steps to obtain: taking formula ratio
Raw medicinal material, appropriate chopping or crushing, setting is suitable for decocting in container, adds 1800ml water immersion medicinal material, after impregnating 1.5 hours, is added
Heat then separates fried liquid after decocting 30 minutes to boiling, and adds 1000ml water again fried 3 times in accordance with the law in the dregs of a decoction, collects each decoct
Out liquid and mix after after being centrifugated or settling filtration, when low temperature is concentrated into 85 DEG C relative density be 1.30 paste.To
Suitable conventional pharmaceutical adjuvants are added in above-mentioned thick paste, are fitted into capsule shells after whole grain, dry disinfection, every capsule weight 0.5g.
Embodiment 5
A kind of drug for treating senile dementia is as made from the raw material of following parts by weight: 25 parts of Radix Astragali, waxgourd seed 10
Part, 8 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of radix aconiti lateralis preparata, 15 parts of Uncinata Spikemoss Herb, 20 parts of fructus viticis, 16 parts of smallflower galinsoga herb, 5 parts of rhizoma zingiberis, 8 parts of folium photiniae, fructus lycii
10 parts of son, 6 parts of Chinese knotweed herb, 12 parts of Ficus lyrata, fries 10 parts of jujube nucleus at 12 parts of Sword Jackbean Seed.
The present embodiment treats the preparation method of the drug of senile dementia, is prepared by the following steps to obtain: taking formula ratio
Raw medicinal material, appropriate chopping or crushing, setting is suitable for decocting in container, adds 1500ml water immersion medicinal material, after impregnating 1.5 hours, is added
Heat then separates fried liquid after decocting 30 minutes to boiling, and adds 1000ml water again fried 2 times in accordance with the law in the dregs of a decoction, collects each decoct
Out liquid and mix after after being centrifugated or settling filtration, when low temperature is concentrated into 85 DEG C relative density be 1.30 paste.To
Suitable conventional pharmaceutical adjuvants are added in above-mentioned thick paste, are fitted into capsule shells after whole grain, dry disinfection, every capsule weight 0.5g.
One, mouse Jumping test
Animal packet: mouse 70,20 ± 2g of weight, half male and half female, random point 7 groups, every group 10, half male and half female,
In two groups be control group, feeding chow diet, three times a day, continuous feeding 30 days；Experimental group 1-5 distinguishes feeding and adds embodiment
The feed of the treatment medicine for senile dementia of 1-5 preparation, additive amount are 20mg/d/, three times a day, continuous feeding 30 days.
Animal model preparation: hyoscine is respectively adopted and causes Memory acquisition sexual dysfunction model, the 1h after last feeding gives
Five groups of mouse for giving experimental group 1-5 carry out intraperitoneal injection scopolamine hydrobromide injection 3mg/kg respectively, volume are injected intraperitoneally
For 10ml/kg；Scopolamine hydrobromide injection is injected intraperitoneally as model control group in the mouse of one group of feeding chow diet
3mg/kg, intraperitoneal injection volume are 10ml/kg；The physiology salt of the capacity such as the blank control group injection of another group of feeding chow diet
Water carries out Jumping test after 10min.
Jumping test: Jumping test case bottom is covered with copper grid as stimulating electrode, and right lateral side places a valve rubber in case
The safety zone of electric shock is escaped as mouse.It is first put into rat and adapts to 5min, be subsequently passed 70V, 0.5A-0.7A electric current, mouse meets with
Normal reaction is to jump onto platform to hide noxious stimulation after to electric shock.It is used from be initially powered up appearing on the stage completely to record rat
Time resurveys afterwards test once to survey memory capability for 24 hours, and experimental result is as shown in table 1.
Data statistics: all data are indicated with (x ± s), are that difference is statistically significant with P < 0.05.
1 mouse Jumping test result of table
Note: * P < 0.05
The above results are shown, compared with blank control group, the learning ability and memory capability of model control group have conspicuousness
Decline illustrates model foundation success.For experimental group 1-5 compared with model control group, learning ability and memory capability have conspicuousness poor
It is different, and be decline, it follows that drug of the invention has remarkable result to treatment senile dementia.
Clinical data
General information: clinical observation old dementia patients 60,2 groups are randomly divided into.Treatment group 30, wherein male 15,
Female 15, the age 62-85 years old, average age 69.2 ± 4.8 years old, course of disease 1-12, average course of disease 5.5 ± 2.4 years；Control group 30
Example, wherein male 16, female 14, the age 61-84 years old, average age 68.9 ± 5.9 years old, course of disease 1-12, average course of disease 5.6 ±
2.2 year.Two groups of patients are not statistically significant (P > 0.05) in the general information comparing difference such as gender, age, the course of disease, state of an illness, tool
There is comparativity.
Diagnostic criteria: using in American Psychiatry disease association fourth edition " diagnostic and statistical manual (DSM--IV) of mental disease "
The diagnostic criteria of senile dementia.1. many-sided cognitive defect occurs, cashes to be following two sides person: (study is new for A. memory defects
The ability of information is impaired or cannot recall pervious acquired information)；B. one of at least following cognitive disorder: (1) aphasia
(2) agnosia (3) appraxia (4) executes the obstacle of managerial ability.2. above-mentioned performance leads to social or occupational function defect, and can
It was found that before these functions are obviously not so good as.3. the onset feature of the course of disease is gradually onset, continuous downturn.4. above-mentioned cognitive defect is simultaneously
Non- to be caused by underlying cause: other lead to memory or recognize the central nervous system situation of progressive defect A, such as: cerebrovascular disease
Deng；The bright general disease for leading to dementia of B reason.5. not due to caused by delirium.6. not due to Serious depression and spirit
Caused by division
Be included in standard: meeting Americanism obstacle to dull-witted clinical criteria, MMSE scoring 10~24/,
Schooling belongs to light moderate senile dementia more than junior middle school, will be with seriousness patient with nervous system disease, the seriousness heart
Lung, liver and kidney disease exclude；With memory disorders, the symptoms such as appraxia and judgment obstacle；Age was at 60-85 years old.
Exclusion criteria: 1. the age is below 60 one full year of life or 85 one full year of life above person；2. cutting out other teams in therapeutic process
The influential drug of cognitive function；3. being associated with the severe primaries disease patient such as angiocarpy, lung, liver, kidney and hemopoietic system；4. essence
Refreshing patient；5. all not by the not congruent judgement person that affects the treatment of regulation medication or data
Treatment method: control group oral hydrochloride donepezil (production of Tianjin Li Sheng pharmaceutcal corporation, Ltd, every 5mg) 5mg,
10min is oral before sleeping, and 20 days are 1 course for the treatment of, shares 3 courses for the treatment of of medicine.The drug of present invention treatment senile dementia, mouth are taken by treatment group
Clothes, three times per day, one time 4,20 days be 1 course for the treatment of, share 3 courses for the treatment of of medicine.Strong tea, coffee, pungent stimulation food are avoided during treatment
Object.
Curative effect determinate standard: curative effect is evaluated according to " diagnosis, differentiation of symptoms and signs for classification of syndrome and the efficacy assessment standard of senile dementia ".
Effective: cardinal symptom is restored substantially, sanity, accurate positioning, answers a question correct, is quick on the draw, and life is certainly
Reason, can be carried out mass society activity；
Effective: main spirits symptom is mitigated or partial disappearance, and basic self-care of living answers a question and is in the main true, but
Slow in reacting, intelligence, personality still have obstacle；Control: main spirits state is without exacerbation, and situation of taking care of oneself variation is unobvious, instead
It is blunt to answer, and intelligence, personality still have obstacle but without exacerbations；
Invalid: cardinal symptom has development can't take care of oneself without change, the state of an illness, answers a question incorrect, mental dementia.
Total effective rate=[(effective+effectively)/total number of cases] × 100%.
Efficacy evaluation: Chinese medicine intelligent comprehensive point system, (1) memory (6 points) are used；(2) directive force (4 points)；(3) thinking
Ability (4 points)；(4) power (4 points) are calculated；(5) affective activity (3 points)；(6) two just function (3 points)；(7) activity of daily living (4
Point).
As a result efficacy assessment standard: MMSE scoring increase and decrease situation carries out efficacy evaluation after treatment before being treated according to patient.It treats
Imitate index: (post treatment integral-pre-treatment score)/pre-treatment score × 100%.
Effective therapeutic index >=20%；
Effective therapeutic index >=12%；
Futile treatment index < 12%；
Deteriorate therapeutic index < -12%.
Therapeutic effect of syndrome judgment criteria
Effective integral increases > 8 and divides or up to 28 points；
Effective integral increases 4-7 points；
Invalid integral increases < 3 and divides.
Treatment results: the treatment results for the treatment of group and control group are shown in Table 2.
2 two groups of clinical treatment outcomes (%) of table
Note: compared with the control group,ΔP < 0.05
As shown in Table 2, effective 10 for the treatment of group, effective 12, invalid 8, total effective rate 73.3%；Control group is effective
5, effective 8, invalid 17, total effective rate 43.3%.2 groups of cure rates and total effective rate comparing difference are statistically significant
(P < 0.05), treatment group's curative effect are better than control group.
In treatment clinical course, the vital sign (blood pressure, heart rate, body temperature, breathing) of patient, physical examination, blood biochemical
Analysis, electrocardiogram and the routine urinalysis Non Apparent Abnormality during treatment.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (3)
1. a kind of drug for treating senile dementia, which is characterized in that be as made from the raw material of following parts by weight: Radix Astragali 15-25
Part, 10-15 parts of waxgourd seed, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of radix aconiti lateralis preparata, 15-20 parts of Uncinata Spikemoss Herb, 10-20 parts of fructus viticis, smallflower galinsoga herb
12-16 parts, 5-10 parts of rhizoma zingiberis, 3-8 parts of folium photiniae, 10-15 parts of fructus lycii, 8-12 parts of Sword Jackbean Seed, 6-10 parts of Chinese knotweed herb, stir-fry acid
10-16 parts of jujube core.
2. treating the drug of senile dementia according to claim 1, which is characterized in that be made by the raw material of following parts by weight
: 18-22 parts of Radix Astragali, 11-13 parts of waxgourd seed, 9-11 parts of Rhizoma Atractylodis Macrocephalae, 11-13 parts of radix aconiti lateralis preparata, 17-19 parts of Uncinata Spikemoss Herb, fructus viticis 13-
18 parts, 13-15 parts of smallflower galinsoga herb, 6-9 parts of rhizoma zingiberis, 4-6 parts of folium photiniae, 11-13 parts of fructus lycii, 9-11 parts of Sword Jackbean Seed, Chinese knotweed herb
7-9 parts, jujube nucleus 12-14 parts of stir-fry.
3. treating the drug of senile dementia according to claim 2, which is characterized in that be made by the raw material of following parts by weight
: 20 parts of Radix Astragali, 12 parts of waxgourd seed, 10 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of radix aconiti lateralis preparata, 18 parts of Uncinata Spikemoss Herb, 15 parts of fructus viticis, 14 parts of smallflower galinsoga herb,
7 parts of rhizoma zingiberis, 12 parts of fructus lycii, 10 parts of Sword Jackbean Seed, 8 parts of Chinese knotweed herb, fries 13 parts of jujube nucleus at 5 parts of folium photiniae.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912597A (en) * | 2010-08-27 | 2010-12-15 | 葛德钜 | Medicament for treating senile dementia and preparation method thereof |
| CN104922286A (en) * | 2015-07-15 | 2015-09-23 | 高淑贤 | Medicine for treating senile dementia and preparation method thereof |
| CN106728639A (en) * | 2016-12-11 | 2017-05-31 | 郑州众易软件开发有限公司 | A kind of Chinese medicine for treating senile dementia |
| CN108653475A (en) * | 2018-08-13 | 2018-10-16 | 吴惠金 | A kind of Chinese medicine and preparation method thereof of prevention senile dementia |
-
2018
- 2018-11-23 CN CN201811437860.6A patent/CN109481656B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912597A (en) * | 2010-08-27 | 2010-12-15 | 葛德钜 | Medicament for treating senile dementia and preparation method thereof |
| CN104922286A (en) * | 2015-07-15 | 2015-09-23 | 高淑贤 | Medicine for treating senile dementia and preparation method thereof |
| CN106728639A (en) * | 2016-12-11 | 2017-05-31 | 郑州众易软件开发有限公司 | A kind of Chinese medicine for treating senile dementia |
| CN108653475A (en) * | 2018-08-13 | 2018-10-16 | 吴惠金 | A kind of Chinese medicine and preparation method thereof of prevention senile dementia |
Non-Patent Citations (4)
| Title |
|---|
| 李玉梅: "老年痴呆辨治体会", 《实用中医药杂志》 * |
| 胡久略: "温肾醒脑方对血管性痴呆大鼠认知功能和神经干细胞增殖的影响", 《辽宁中医药杂志》 * |
| 赵立群: "朱振铎教授治疗老年痴呆经验", 《中医药学刊》 * |
| 陈冠勋: "老年性痴呆的辨治体会", 《河北中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112717031A (en) * | 2021-01-13 | 2021-04-30 | 诸城市精神卫生中心 | Pharmaceutical composition for treating Alzheimer's disease and preparation method thereof |
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