CN108030074A - Improve complex nutrient preparation of plateau lower oxygen concentration resistance adaptability and preparation method thereof - Google Patents
Improve complex nutrient preparation of plateau lower oxygen concentration resistance adaptability and preparation method thereof Download PDFInfo
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- CN108030074A CN108030074A CN201711287208.6A CN201711287208A CN108030074A CN 108030074 A CN108030074 A CN 108030074A CN 201711287208 A CN201711287208 A CN 201711287208A CN 108030074 A CN108030074 A CN 108030074A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Abstract
The present invention relates to the micro composite nutrient technical field of food, more particularly to improve the complex nutrient preparation of plateau lower oxygen concentration resistance adaptability and preparation method thereof, it is the soft capsule for including core contents and capsule skin, core contents include 0.86 part of vitamin V A, vitamin V B12.0~3.0 parts, vitamin V B22.3~2.8 parts, 40~50 parts of nicotinic acid, 50~70 parts of vitamin V C, 15~20 parts of vitamin V E, 3.5~5.5 parts of panaxoside, 4.5~6.5 parts of spina date seed, 6~8 parts of ganoderma lucidum polysaccharide；Capsule skin includes gelatin, glycerine, additives, opacifier and distilled water.The complex nutrient preparation drug effect of the present invention is rapid-action, the continuous action time is long and without side-effects, hypoxia-bearing capability can be improved, strengthen immunity of organisms, with cardiac stimulant tonifying Qi, enrich blood, the effect of tranquilizing and allaying excitement, balance of the body under anaerobic environment is adjusted, high altitude anoxia adaptability is improved by human nutrition intervention.
Description
Technical field
The present invention relates to food nutrition agent technical field, more particularly to improve the compound nutritional of plateau lower oxygen concentration resistance adaptability
Preparation and preparation method thereof.
Background technology
In recent years, country strengthens construction to Tibet, many batches of in order to develop plateau resource, safeguard and the height that builds up one's motherland
Former, borderland the personnel and by interior the Chinese people bodyguard to plateau enters Tibet of aiding Tibet interiorly, they need long-term work with
Live in the environment of plateau hypobaric hypoxia, the altitude sickness thus triggered is influenced to bringing great puzzlement to them
They are normal to work and lives；In addition, Tibet train is open-minded, the convenient door of Xizang road bridge is opened, people are to see
The original landscape and natural views in Tibet swarm forward, but altitude sickness makes most people's pain worry, and altitude sickness is to man-machine
The harmful effect of body so that people lose the excitement played, it has to rest in room, or even groups of people are because of strong height
Original reaction has to abandon to appreciate plateau beautiful scenery scene and return, and makes some not to the people on plateau once mentioning altitude sickness to removing height
Original tourism is hung back.
The area that more than 3000 meters of height above sea level, is known as highlands.There is rarefaction of air, air to force down for highlands, oxygen
Force down, is cold, the features such as wind is big, ultraviolet is strong.Numerous studies are shown, under hypoxic plateau environment, energy and battalion in human body
Support element VA, VB1, VB2, VC and trace elements iron intake is reduced, so that enzyme and energetic supersession are influenced, to myocardial enzymes and freedom
Base damage has an impact.After the people of low altitude area enters plateau, due to the change dramatically of weather etc., normal person is exceeded
The limit of body automatic adjustment.The function of Induced by Hypoxia vivo system changes, and causes a variety of hypoxic conditions, and health is threatened
It is very big.Anoxic early stage, body excite corresponding adaptation reaction by a series of induction mechanisms, as mitochondria number increases, have
Oxygen metabolism enzyme system is expressed and activity change, by Metabolism regulation, strengthens the transport of oxygen and using efficiency, to ensure important organ
The heart, brain cell energy supply.And the clinical symptoms of acute high altitude hypoxia reaction then show as headache, dizzy, nervous, uncomfortable in chest, evil
The heart, vomiting, it is weak, receive that poor, sleep-disorder, brothers are numb, and face and four limbs may occur in which oedema etc., such as cannot be properly at treatment
Reason, can develop into plateau pneumochysis and plateau brain edema etc., the life security of entail dangers to sufferer, the prevention of polarity altitude sickness and
Treat as one of the difficult point in current medical field.
Medicine currently used for treating altitude sickness is quick, but side reaction is more serious, such as acetazolamide diamox, furosemide
It is usually used in preventing the edema disease caused by the discomfort of plateau.There are sleepy, facial and four using acetazolamide diamox common adverse reactions
Acroanesthesia sense, can cause kidney complications etc.；Excessive use furosemide sulfanilamide (SN) is likely to occur slight nausea, diarrhea, drug rash, scabies
Itch, the adverse reaction such as eye-blurred；In addition, common inhibitor, Inosine tablets, glucose etc. are often influenced by individual technical ability condition,
Dose is larger, and effect is less obvious；It is grown in addition, also having using Rhodiola rosea capsules prevention acute high altitude reaction, rhodiola root
More stone and coarse sand mountainous regions of 3500~5100 meters of height above sea level, it is big to have adapted to anoxic, high and cold, dry, strong ultraviolet radiation, diurnal temperature
Etc. most evil bad changeable natural environment, therefore possess anti anoxia, anti-blast, radioresistance, the special drug effect of low-temperature resistance drying, but
It is to take rhodiola rosea formulated product process up to one week, slow and unstable, clinical response unsatisfactory curative effect is acted on, especially to clinical head
The symptom effect such as bitterly, dizzy, uncomfortable in chest is unsatisfactory.
Currently, China goes to highlands tourism, the people of Working Life up to as many as ten million every year, and with annual 15% speed
Degree increases.Therefore, the medicine with resisting oxygen lack and Small side effects of the efficient holding effect of development and production, health products are with wide
Market prospects and good social benefit.
The content of the invention
In view of this, the object of the present invention is to provide the complex nutrient preparation and its system for improving plateau lower oxygen concentration resistance adaptability
Preparation Method, the complex nutrient preparation drug effect being prepared into is rapid-action, long action time and without side-effects, body can be promoted to resist tired
Labor, improves hypoxia-bearing capability, strengthens immunity of organisms, has cardiac stimulant tonifying Qi, enriches blood, the effect of tranquilizing and allaying excitement, adjusts body and exists
Balance under anaerobic environment, high altitude anoxia adaptability is improved by human nutrition intervention.
The present invention solves above-mentioned technical problem by following technological means：
The complex nutrient preparation of plateau lower oxygen concentration resistance adaptability is improved, the complex nutrient preparation is to include core contents
With the soft capsule of capsule skin, the core contents include the raw material of following parts by weight：0.86 part of vitamin V A, vitamin
VB12.0~3.0 parts, vitamin V B22.3~2.8 parts, 40~50 parts of nicotinic acid, 50~70 parts of vitamin V C, vitamin V E 15~
20 parts, 3.5~5.5 parts of panaxoside, 4.5~6.5 parts of spina date seed, 6~8 parts of ganoderma lucidum polysaccharide.
Based on the above technical solutions, the present invention has also done following improvement：
Further, the capsule skin includes gelatin, glycerine, additives, opacifier and distilled water, and the gelatin, glycerine, add
The mass ratio of agent, opacifier and water is 10:(4~5):(0.1~0.2):(0.05~0.1):(10~12).
Further, the additives are one kind in hydroxyethyl starch, hydroxypropul starch, and the opacifier is titanium dioxide
Titanium.
In addition, the invention also discloses the preparation method of the above-mentioned complex nutrient preparation for being used to alleviate altitude sickness, including
Following steps：
The configuration of content, takes vitamin V A, vitamin V B1, vitamin V B2, nicotinic acid, vitamin V C, vitamin V E, people
Ginseng saponin, spina date seed, ganoderma lucidum polysaccharide, which are added in colloid mill, grinds 1h, obtains core contents, stand-by；
The configuration of capsule hide glue gelatin, will be uniformly mixed in glycerine and distilled water being put into glue tank, is heated to 80~85 DEG C of inputs
Gelatin, additives and opacifier stirring, are again heated to 90 DEG C to whole meltings, decompression vacuum pumping degassing, crosses 100 mesh sieves, obtain
Glue is stand-by；
Pelletization drying is suppressed, content and capsule hide glue gelatin are transferred in pellet press after pelleting processing, shaped into rolling in cage
1.5~2h is handled, obtained capsule pill drying to the capsule severe edema due to hypofunction of the spleen point is less than 11%, obtains soft capsule, i.e. complex nutrient preparation.
Further, the rotating speed of the pelleting processing is controlled in 4~6r/min, and sprinkler body temperature control is at 40~45 DEG C.
Further, the temperature of the heat treatment for 20~25 DEG C, relative humidity be 35%.
Further, the temperature conditionss of the capsule pill drying are 20~25 DEG C, and relative humidities are 20%.
Further, the capsule skin thickness of soft capsule prepared by the method is 0.85~0.90mm, and loading amount is 0.5g/.
Beneficial effects of the present invention：The present invention complex nutrient preparation in containing the vitamin closely related with oxygen metabolism,
Trace element and the nutrient such as amino acid, panaxoside therein, spina date seed, ganoderma lucidum polysaccharide can cooperate with promotion body fatigue resistance,
Hypoxia-bearing capability is improved, strengthens immunity of organisms, there is cardiac stimulant tonifying Qi, enrich blood, the effect of tranquilizing and allaying excitement, adjusts body in anoxic
Balance under environment, high altitude anoxia adaptability is improved by human nutrition intervention；Make in the complex nutrient preparation of the present invention
With traditional Chinese medicine ganoderma lucidum, ganoderma lucidum has the effect of benefiting qi and nourishing blood, mental-tranquilization, and ganoderma lucidum polysaccharide can promote and adjust body to exempt from
Epidemic disease function, promotes the synthesis of human nucleic acid and protein, removes free radical, prevents damage of the free radical to alveolar, and protection lung is thin
Born of the same parents, it is nervous for just entering hypoxic plateau environment in addition, ganoderma lucidum has effects that tranquilizing and allaying excitement, palpitating speed and cause to lose
Sleep, it is qi-blood deficiency caused by high altitude anoxia to be respectively provided with extraordinary curative effect；Soft capsule is made in the complex nutrient preparation of the present invention,
Holding time extends, and up to 3 years as long as, capsule small volume, convenient to take, bioavailability was higher, and drug effect is rapid-action, holds
It is continuous permanent and without side-effects；The complex nutrient preparation of the present invention for be initially entered the local work personnel on plateau, Male Soldiers,
Traveller and it is respectively provided with the resident of low altitude area with asthma, acute and chronic tracheitis, bronchitis and pulmonary heart disease etc. good
The effect of good, can improve cardiopulmonary anoxic conditions, mitigate respiratory disease symptom, favourable patients ' recovery.
Embodiment
Below with reference to specific embodiment, the present invention is described in detail：
The complex nutrient preparation for being used to improve plateau lower oxygen concentration resistance adaptability of the present invention, is to include core contents and capsule
The soft capsule of skin, core contents include the raw material of following parts by weight：0.86 part of vitamin V A, vitamin V B12.0~3.0
Part, vitamin V B22.3~2.8 parts, 40~50 parts of nicotinic acid, 50~70 parts of vitamin V C, 15~20 parts of vitamin V E, ginseng
3.5~5.5 parts of saponin, 4.5~6.5 parts of spina date seed, 6~8 parts of ganoderma lucidum polysaccharide, wherein, additives are hydroxyethyl starch, hydroxypropyl
One kind in starch, opacifier are titanium dioxide；Capsule skin includes gelatin, glycerine, additives, opacifier and distilled water, gelatin, sweet
Oil, additives, the mass ratio of opacifier and water are 10:(4~5):(0.1~0.2):(0.05~0.1):(10~12).
The preparation method of the complex nutrient preparation for improving plateau lower oxygen concentration resistance adaptability of the present invention is as follows：
The configuration of content, takes vitamin V A, vitamin V B1, vitamin V B2, nicotinic acid, vitamin V C, vitamin V E, people
Ginseng saponin, spina date seed, ganoderma lucidum polysaccharide, which are added in colloid mill, grinds 1h, obtains core contents, stand-by；The configuration of capsule hide glue gelatin, will
It is uniformly mixed in glycerine and distilled water being put into glue tank, is heated to 80~85 DEG C of input gelatin, additives and opacifier stirring, then
90 DEG C are heated to whole meltings, decompression vacuum pumping degassing, crosses 100 mesh sieves, it is stand-by to obtain glue；Pelletization drying is suppressed, by
Tolerant and capsule hide glue gelatin is transferred to pelleting in pellet press and handles, and the rotating speed of pelleting processing is controlled in 4~6r/min, sprinkler body temperature control
At 40~45 DEG C, 1.5~2h of heat treatment in rolling cage is subsequently entered, the temperature of heat treatment is 20~25 DEG C, relative humidity is
35%, the capsule pill drying obtained after sizing to the capsule severe edema due to hypofunction of the spleen point is less than 11%, and dry temperature conditionss are 20~25 DEG C, relatively wet
Degree condition is 20%, and soft capsule, i.e. complex nutrient preparation are obtained after dry, and the capsule skin thickness of soft capsule is 0.85~0.90mm,
Loading amount is 0.5g/.
Wherein, the ganoderma lucidum polysaccharide that the present invention uses is plural gel, is to answer ovalbumin, ganoderma lucidum polysaccharide and ganoderma lucidum polypeptide
Obtained microgel is closed, ganoderma lucidum polysaccharide is made into microgel and increases specific surface area, the work(of ganoderma lucidum polysaccharide tranquilizing and allaying excitement can be extended
Effect, further such that more lasting the effect of the complex nutrient preparation.Preparing for the ganoderma lucidum polysaccharide plural gel of the present invention is as follows：
By ovalbumin and ganoderma lucidum polysaccharide in mass ratio 2:1 priority is dissolved in phosphate buffer, is made into the protein solution of 10g/L, cold
Lyophilized dry rear grinding, is subsequently placed in culture dish, 60 DEG C of temperature, 70% relative humidity ring is placed on the aluminium foil sealing of acanthopore
10h is reacted under border, cooling is taken out and obtains ovalbumin-ganoderma lucidum polysaccharide compound, Cord blood；Take ovalbumin-ganoderma lucidum polysaccharide
Compound is dissolved in distilled water, and ultrasonic wave makes it fully dissolve, and adds the ganoderma lucidum polypeptide stirring of ganoderma lucidum polysaccharide equal quality
30min, adjusts pH=5 with the hydrochloric acid solution of 0.1mol/L, continues to stir 30min, rapid cold in 85 DEG C of water-bath 30min
But ice-bath ultrasonic process 5min, that is, obtain the plural gel containing ganoderma lucidum polysaccharide and ganoderma lucidum polypeptide after.
In addition, the opacifier titanium dioxide that the present invention uses is porous hollow micro-sphere structure, porous hollow micro-sphere structure
For titanium dioxide due to the specific surface area with unique hollow structure and super large, stability is good, has superpower material conveying, table
Face is permeated and good optical property, its shading performance are stronger.The titanium dioxide for the porous hollow micro-sphere structure that the present invention uses
Prepare it is as follows：The concentrated sulfuric acid of 5g surfaces crosslinked polystyrene microsphere with holes, the concentrated nitric acid of 100mL, 100mL are taken at 38 DEG C
3h is reacted, reaction product centrifuge washing is taken out to neutrality, obtains the crosslinked polystyrene microsphere of nitration；Add mass fraction
For 20% sodium hydroxide solution and sodium peroxydisulfate, react 5h in 70 DEG C and obtain amidized crosslinked polystyrene microsphere；Take 2g
Amidized crosslinked polystyrene microsphere, 100mL absolute ethyl alcohols, 20mL glacial acetic acid, 20mL deionized waters, are slowly added dropwise metatitanic acid fourth
Ester solution, in 35 DEG C of water-bath 3h, taking-up reactant is multiple with ultra-pure water centrifuge washing, and drying and grinding obtains powder, by powder
End is put into tube furnace, is calcined 5h in air atmosphere in 400 DEG C or so, is obtained the titanium dioxide of porous hollow micro-sphere structure.
Embodiment one
The preparation method of the complex nutrient preparation of the raising plateau lower oxygen concentration resistance adaptability of the present embodiment is as follows：
The configuration of content, takes vitamin V A 0.86mg, vitamin V B12.0mg, vitamin V B22.3mg, nicotinic acid 50mg,
Vitamin V C 50mg, vitamin V E 15mg, panaxoside 5.5mg, spina date seed 4.5mg, ganoderma lucidum polysaccharide 8mg are added in colloid mill
1h is ground, obtains core contents, it is stand-by；
The configuration of capsule hide glue gelatin, the mass ratio of gelatin, glycerine, additives, opacifier and water in the present embodiment is 10:4:
1.5:1:10, take in glycerine 40g and distilled water 100g being put into glue tanks and be uniformly mixed, be heated to 80 DEG C of input gelatin 100g, hydroxyls
Hydroxyethyl starch 1.5g and titanium dioxide 1g stirrings, are again heated to 90 DEG C and deaerate to whole meltings, decompression vacuum pumping, cross 100 mesh sieves,
Glue is obtained, it is stand-by；
Pelletization drying is suppressed, by content and capsule hide glue gelatin in mass ratio 1:3 mixing, are transferred to rapidly in pellet press at pelleting
Reason, the rotating speed control of pelleting processing enter sizing in rolling cage in 4r/min, sprinkler body temperature control after 40~45 DEG C, pelleting processing
1.5h is handled, the temperature of heat treatment is 20 DEG C, relative humidity is 35%, the capsule pill drying obtained after sizing to the capsule severe edema due to hypofunction of the spleen point
Less than 11%, dry temperature conditionss are 20 DEG C, and relative humidities are 20%, and soft capsule, i.e. compound nutritional are obtained after dry
Preparation, the capsule skin thickness of soft capsule is 0.85~0.90mm, and loading amount is about 0.5g/.
Embodiment two
The preparation method of the complex nutrient preparation of the raising plateau lower oxygen concentration resistance adaptability of the present embodiment is as follows：
The configuration of content, takes vitamin V A 0.855mg, vitamin V B12.6mg, vitamin V B22.5mg, nicotinic acid
47mg, vitamin V C 60mg, vitamin V E 18mg, panaxoside 5mg, spina date seed 5mg, ganoderma lucidum polysaccharide 5mg add colloid mill
Middle mill 1h, obtains core contents, stand-by；
The configuration of capsule hide glue gelatin, the mass ratio of gelatin, glycerine, additives, opacifier and water in the present embodiment is 10:
4.5:1:0.5:11, take in glycerine 45g and distilled water 110g being put into glue tanks and be uniformly mixed, be heated to 85 DEG C of input gelatin
100g, hydroxypropul starch 1g and titanium dioxide 0.5g stirrings, are again heated to 90 DEG C to whole meltings, decompression vacuum pumping degassing, mistake
100 mesh sieves, obtain glue, stand-by；
Pelletization drying is suppressed, by content and capsule hide glue gelatin in mass ratio 3:7 mixing, are transferred to rapidly in pellet press at pelleting
Reason, the rotating speed control of pelleting processing enter sizing in rolling cage in 5r/min, sprinkler body temperature control after 40~45 DEG C, pelleting processing
2h is handled, the temperature of heat treatment is 23 DEG C, relative humidity is 35%, and the capsule pill drying obtained after sizing is low to the capsule severe edema due to hypofunction of the spleen point
In 11%, dry temperature conditionss are 23 DEG C, and relative humidities are 20%, and soft capsule, i.e. compound nutritional system are obtained after dry
Agent, the capsule skin thickness of soft capsule is 0.85~0.90mm, and loading amount is about 0.5g/.
Embodiment three
The preparation method of the complex nutrient preparation of the raising plateau lower oxygen concentration resistance adaptability of the present embodiment is as follows：
The configuration of content, takes vitamin V A 0.86mg, vitamin V B13.0mg, vitamin V B22.8mg, nicotinic acid 40mg,
Vitamin V C 70mg, vitamin V E 20mg, panaxoside 3.5mg, spina date seed 6.5mg, ganoderma lucidum polysaccharide 6mg are added in colloid mill
1h is ground, obtains core contents, it is stand-by；
The configuration of capsule hide glue gelatin, the mass ratio of gelatin, glycerine, additives, opacifier and water in the present embodiment is 10:5:
2:0.8:12, take in glycerine 50g and distilled water 120g being put into glue tanks and be uniformly mixed, be heated to 82 DEG C of input gelatin 100g, hydroxyls
Propyl group starch 2g and titanium dioxide 0.8g stirrings, are again heated to 90 DEG C and deaerate to whole meltings, decompression vacuum pumping, cross 100 mesh sieves,
Glue is obtained, it is stand-by；
Pelletization drying is suppressed, by content and capsule hide glue gelatin in mass ratio 3:7 mixing, are transferred to rapidly in pellet press at pelleting
Reason, the rotating speed control of pelleting processing enter sizing in rolling cage in 6r/min, sprinkler body temperature control after 40~45 DEG C, pelleting processing
1.6h is handled, the temperature of heat treatment is 25 DEG C, relative humidity is 35%, the capsule pill drying obtained after sizing to the capsule severe edema due to hypofunction of the spleen point
Less than 11%, dry temperature conditionss are 25 DEG C, and relative humidities are 20%, and soft capsule, i.e. compound nutritional are obtained after dry
Preparation, the capsule skin thickness of soft capsule is 0.85~0.90mm, and loading amount is about 0.5g/.
Zoopery：
Randomly select SPF grades, the healthy male mice 80 that weight is 19~21g, mouse is randomly divided into three groups by weight,
Every group each 40, one of which nutritional preparation for composite tests mouse oxygen deficit tolerance, and another group is simulated in hypobaric chamber
Different altitude height, hypobaric hypoxia experiment is carried out to mouse.
1st, oxygen deficit tolerance is tested：Mouse is divided into four groups, every group 10, and respectively prepared by the embodiment one to sample equal quality
Complex nutrient preparation, embodiment two prepare complex nutrient preparation, embodiment three prepare complex nutrient preparation as experiment
Group, the distilled water to sample equal quality are 0.2g/kg to sample amount depending on mice weights as a control group.By these mouse
Continuous gavage one month, after last gives sample 1h respectively, mouse is respectively put into the 250mL port grinding bottles for filling 5g soda limes (every
1, bottle), bottleneck is sealed with vaseline, covers tightly, is allowed to air tight, immediately timing, until mouse breathing stops, record mouse is because lacking
Oxygen and the time of death, as a result such as table 1.
| Packet | Time-to-live (min) |
| Embodiment one | 49.08±3.87 |
| Embodiment two | 49.98±3.51 |
| Embodiment three | 49.23±3.74 |
| Control group | 31.62±3.46 |
Table 1
2nd, hypobaric hypoxia is tested：Same mouse is divided into four groups, every group 10, and the embodiment one to sample equal quality is made respectively
Complex nutrient preparation prepared by complex nutrient preparation prepared by standby complex nutrient preparation, embodiment two, embodiment three is as examination
Group is tested, the distilled water to sample equal quality is 0.2g/kg to sample amount depending on mice weights as a control group.These are small
Mouse continuous gavage one month, after last gives sample 1h respectively, mouse is respectively put into hypobaric chamber, is allowed to air tight, immediately timing,
Until mouse breathing stops, the record mouse time dead because of anoxic, as a result such as table 2.
Table 2
The above results show that complex nutrient preparation of the invention shows good lower oxygen concentration resistance energy relative to control group
Power, can promote body fatigue resistance, improve hypoxia-bearing capability, strengthen immunity of organisms, have cardiac stimulant tonifying Qi, enrich blood, calm peace
The effect of god, adjusts balance of the body under anaerobic environment, high altitude anoxia adaptability is improved by human nutrition intervention.Separately
Outside, complex nutrient preparation of the invention is for being initially entered the local work personnel on plateau, Male Soldiers, traveller and in low sea
Pull out in Area Inhabitants and be respectively provided with the effect of good with asthma, acute and chronic tracheitis, bronchitis and pulmonary heart disease etc., the heart can be improved
Lung anoxic conditions, mitigate respiratory disease symptom, favourable patients ' recovery.
The above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, although with reference to preferred embodiment to this hair
It is bright to be described in detail, it will be understood by those of ordinary skill in the art that, it can modify to technical scheme
Or equivalent substitution, without departing from the objective and scope of technical solution of the present invention, it should all cover the claim in the present invention
Among scope.The present invention be not described in detail technology, shape, construction part be known technology.
Claims (8)
1. improve the complex nutrient preparation of plateau lower oxygen concentration resistance adaptability, it is characterised in that the complex nutrient preparation is to include
The soft capsule of core contents and capsule skin, the core contents include the raw material of following parts by weight：Vitamin V A 0.86
Part, vitamin V B12.0~3.0 parts, vitamin V B22.3~2.8 parts, 40~50 parts of nicotinic acid, 50~70 parts of vitamin V C, dimension
Raw 15~20 parts of element VE, 3.5~5.5 parts of panaxoside, 4.5~6.5 parts of spina date seed, 6~8 parts of ganoderma lucidum polysaccharide.
2. the complex nutrient preparation according to claim 1 for improving plateau lower oxygen concentration resistance adaptability, it is characterised in that described
Capsule skin includes gelatin, glycerine, additives, opacifier and distilled water, the gelatin, glycerine, additives, the quality of opacifier and water
Than for 10:(4~5):(0.1~0.2):(0.05~0.1):(10~12).
3. the complex nutrient preparation according to claim 2 for improving plateau lower oxygen concentration resistance adaptability, it is characterised in that described
Additives are hydroxyethyl starch, one kind in hydroxypropul starch.
4. the preparation method of the complex nutrient preparation according to claim 3 for improving plateau lower oxygen concentration resistance adaptability, it is special
Sign is, comprises the following steps：
The configuration of content, takes vitamin V A, vitamin V B1, vitamin V B2, nicotinic acid, vitamin V C, vitamin V E, ginseng soap
Glucoside, spina date seed, ganoderma lucidum polysaccharide, which are added in colloid mill, grinds 1h, obtains core contents, stand-by；
The configuration of capsule hide glue gelatin, will in glycerine and distilled water being put into glue tank be uniformly mixed, be heated to 80~85 DEG C input gelatin,
Additives and opacifier stirring, are again heated to 90 DEG C to whole meltings, decompression vacuum pumping degassing, crosses 100 mesh sieves, obtain glue and treat
With；
Suppress pelletization drying, after content and capsule hide glue gelatin are transferred in pellet press pelleting processing, into rolling cage in heat treatment
1.5~2h, obtained capsule pill drying to the capsule severe edema due to hypofunction of the spleen point are less than 11%, obtain soft capsule, i.e. complex nutrient preparation.
5. the preparation method of the complex nutrient preparation according to claim 4 for improving plateau lower oxygen concentration resistance adaptability, it is special
Sign is that the rotating speed of the pelleting processing is controlled in 4~6r/min, and sprinkler body temperature control is at 40~45 DEG C.
6. the preparation method of the complex nutrient preparation according to claim 5 for improving plateau lower oxygen concentration resistance adaptability, it is special
Sign is, the temperature of the heat treatment is 20~25 DEG C, relative humidity is 35%.
7. the preparation method of the complex nutrient preparation according to claim 6 for improving plateau lower oxygen concentration resistance adaptability, it is special
Sign is that the temperature conditionss of the capsule pill drying are 20~25 DEG C, and relative humidities are 20%.
8. the preparation method of the complex nutrient preparation according to claim 7 for improving plateau lower oxygen concentration resistance adaptability, it is special
Sign is that the capsule skin thickness of soft capsule prepared by the method is 0.85~0.90mm, and loading amount is 0.5g/.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115836732A (en) * | 2022-11-24 | 2023-03-24 | 中国人民解放军陆军勤务学院 | High-altitude functional adhesive with functions of hypoxia resistance and immunity enhancement and preparation method thereof |
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|---|---|---|---|---|
| CN101279049A (en) * | 2007-04-06 | 2008-10-08 | 王洪飞 | Soft capsules for resisting altitude stress |
| CN102894444A (en) * | 2012-10-15 | 2013-01-30 | 康美药业股份有限公司 | Ginseng functional drink, preparation method of ginseng functional drink and application of ginseng functional drink |
| CN104544130A (en) * | 2014-12-17 | 2015-04-29 | 山东天地健生物工程有限公司 | Soft capsule for improving alimentary anemia and preparation method of soft capsule |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279049A (en) * | 2007-04-06 | 2008-10-08 | 王洪飞 | Soft capsules for resisting altitude stress |
| CN102894444A (en) * | 2012-10-15 | 2013-01-30 | 康美药业股份有限公司 | Ginseng functional drink, preparation method of ginseng functional drink and application of ginseng functional drink |
| CN104544130A (en) * | 2014-12-17 | 2015-04-29 | 山东天地健生物工程有限公司 | Soft capsule for improving alimentary anemia and preparation method of soft capsule |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115836732A (en) * | 2022-11-24 | 2023-03-24 | 中国人民解放军陆军勤务学院 | High-altitude functional adhesive with functions of hypoxia resistance and immunity enhancement and preparation method thereof |
| CN115836732B (en) * | 2022-11-24 | 2023-11-21 | 中国人民解放军陆军勤务学院 | High-prototype functional adhesive with functions of hypoxia tolerance and immunity enhancement and preparation method thereof |
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