CN105687480A - Immunoregulatory traditional Chinese medicine composition and preparation - Google Patents

Immunoregulatory traditional Chinese medicine composition and preparation Download PDF

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Publication number
CN105687480A
CN105687480A CN201610121170.4A CN201610121170A CN105687480A CN 105687480 A CN105687480 A CN 105687480A CN 201610121170 A CN201610121170 A CN 201610121170A CN 105687480 A CN105687480 A CN 105687480A
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chinese medicine
immunoregulatory
medicine composition
tremella
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周建湘
肖玉平
吴坚麟
黄晓君
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Guangdong Fushouxian Biotechnology Co Ltd
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

The invention discloses an immunoregulatory traditional Chinese medicine composition and a preparation. According to the formulation, the immunoregulatory traditional Chinese medicine composition is prepared from, by weight, 40-60 parts of ganoderma, 40-60 parts of monkey head mushrooms, 40-60 parts of tremella, 30-50 parts of lentinus edodes, 30-50 parts of poria cocos, 10-30 parts of milkvetch roots, 10-30 parts of lotus seeds, 20-40 parts of fructus lycii, 10-30 parts of radix codonopsis and 10-30 parts of gorgon fruits. Main effective ingredients of Chinese herbal medicine under compatibility include biotic polysaccharide, protein, flavonoid and the like, the functional ingredients are in scientific compatibility, and the immunomodulatory effect is good. Besides, the immunoregulatory traditional Chinese medicine composition aims at performing regulation, supporting the healthy energy, invigorating the spleen and stomach, supplementing both qi and blood and the like, and can enhance the immunologic function and disease resistance of an organism.

Description

A kind of immunoregulatory Chinese medicine composition and preparation
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of immunoregulatory Chinese medicine composition。
Background technology
Immunity is the meaning of " release pestilence " the earliest, refers to the health resistance again infecting generation to infectious agent, and the power of resistance can be expressed by immunity。So-called infectious agent refers to the pathogenic microorganism such as antibacterial, virus, and this just makes immunity and microbiology closely related, makes to it is believed that immunity only refers to the health defense function to infecting, and health is all advantageous for by immunity。Along with going deep into of research, immunity be there has also been new understanding, the early stage concept thinking above-mentioned can not definitely reflect the essence of immunity because it is found that the anaphylaxis unrelated with infectious disease, organ-graft refection, tumor develop, sterile, old and feeble etc. actually all relevant with immunity。So the Concept of Immunity in modern times should refer to health identification " self " and the activity of " dissident ", it it is exactly a kind of activity distinguishing " enemy ", " I ", " dissident " (enemy) can be the organ in he human blood, the transplant that the blood group that the microorganism in intrusive body, blood transfusion accidentally enter is not inconsistent, be different from the tumor cell etc. of body normal components, this all of " foreign body " that body can be stimulated to produce immunne response, is referred to as " antigen "。The immune function of body, is first to discriminate between self and dissident's composition, then passes through immunologic process, is eventually exhibited as the repulsion to dissident's composition (antigen), and the consequence that this repulsion causes is many favourable to body, such as opposing infection etc.；But body is then harmful to by some, as there is anaphylaxis, autoimmune disease etc., so it is considered that it is incomplete that body is all advantageous for concept by immunity。
Current people use the method regulating immunity a lot, but respectively have superiority and be respectively arranged with deficiency, so research and development have its huge social value and economic worth with China's Chinese material medicine resource advantage and product that motherland's theory of medicine advantage is background, no side effects, super quality and competitive price。
Summary of the invention
For solving the problems referred to above, it is an object of the invention to provide immunoregulatory Chinese medicine composition, it has adjustment immunologic function, no side effects, super quality and competitive price。
The object of the present invention is achieved like this: a kind of immunoregulatory Chinese medicine composition, it is characterized in that: calculate by weight, its formula is composed of the following components: Ganoderma 40～60 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 40～60 parts, 40～60 parts of Tremella, 30～50 parts of Lentinus Edodes, 30～50 parts of Poria, the Radix Astragali 10～30 parts, 10～30 parts of Semen Nelumbinis, Fructus Lycii 20～40 parts, Radix Codonopsis 10～30 parts, Semen Euryales 10～30 parts。
Preferably, calculating by weight, its formula is composed of the following components: Ganoderma 45～55 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 45～55 parts, 45～55 parts of Tremella, 35～45 parts of Lentinus Edodes, 35～45 parts of Poria, the Radix Astragali 15～25 parts, 15～25 parts of Semen Nelumbinis, Fructus Lycii 25～35 parts, Radix Codonopsis 15～25 parts, Semen Euryales 15～25 parts。
Optimum, calculating by weight, its formula is composed of the following components: Ganoderma 50 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 50 parts, 50 parts of Tremella, 45 parts of Lentinus Edodes, 40 parts of Poria, the Radix Astragali 15 parts, 20 parts of Semen Nelumbinis, Radix Codonopsis 10 parts, Fructus Lycii 20 parts, Semen Euryales 20 parts。
A kind of immunoregulatory Chinese medicine preparation, including effective ingredient, this effective ingredient is the extract of above-mentioned immunoregulatory Chinese medicine composition。
The dosage form of described Chinese medicine preparation is oral liquid, electuary, capsule or tablet。
The extract of described Chinese medicine composition is water extract。
The Chinese herbal medicine principle active component of compatibility of the present invention is biological polyoses, protein, flavonoid etc., functional component proportioning science, immunoregulation effect effect is good, additionally, currently invention addresses adjustment, strengthening the body resistance, spleen reinforcing stomach invigorating, qi and blood tonifying etc. can the immunologic function of enhancing body and resistances against diseases。
Detailed description of the invention
The present invention is a kind of immunoregulatory Chinese medicine composition, calculating by weight, its formula is composed of the following components: Ganoderma 40～60 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 40～60 parts, 40～60 parts of Tremella, 30～50 parts of Lentinus Edodes, 30～50 parts of Poria, the Radix Astragali 10～30 parts, 10～30 parts of Semen Nelumbinis, Fructus Lycii 20～40 parts, Radix Codonopsis 10～30 parts, Semen Euryales 10～30 parts。
Preferably, calculating by weight, its formula is composed of the following components: Ganoderma 45～55 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 45～55 parts, 45～55 parts of Tremella, 35～45 parts of Lentinus Edodes, 35～45 parts of Poria, the Radix Astragali 15～25 parts, 15～25 parts of Semen Nelumbinis, Fructus Lycii 25～35 parts, Radix Codonopsis 15～25 parts, Semen Euryales 15～25 parts。
Optimum, calculating by weight, its formula is composed of the following components: Ganoderma 50 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 50 parts, 50 parts of Tremella, 45 parts of Lentinus Edodes, 40 parts of Poria, the Radix Astragali 15 parts, 20 parts of Semen Nelumbinis, Fructus Lycii 20 parts, Radix Codonopsis 10 parts, Semen Euryales 20 parts。
In the medicinal raw material that the present invention adopts, Ganoderma: Ganoderma is the basidiomycetes of Polyporaceae, it begins to be loaded in the Shennong's Herbal of Han dynasty as medicine, and successive dynasties medical book is classified as top grade。Ganoderma has the effect such as invigorating the spleen and replenishing QI, relieving cough and asthma, for diseases such as malaise, insomnia cardiopalmus, cough and asthma due to lung deficiency, asthenia is losed heart, anorexias。Ganoderma is a kind of Chinese crude drug that " Chinese Pharmacopoeia " includes, and is also a kind of fungus of dietotherapeutic。Ganoderma is containing ganoderan, triterpenoid compound etc.；Modern pharmacological research shows, Ganoderma has many-sided biological activity, including antitumor, protect the liver, immunomodulating, to central nervous system, immune system, cardiovascular system, blood sugar lowering, blood fat reducing, defying age, antioxidation, raising body's hypoxia tolerance and resisting fatigue, additionally it is possible to anti-inflammation, relieving cough and asthma, eliminate the phlegm and treat chronic tracheitis etc.。
Tremella: Tremella Tremellaceae, Tremella fungus, is famous and precious nutritious tonifying good merchantable brand, is again the strong tonic of righting, and its tremella polysaccharide has the pharmacological actions such as immunostimulant, defying age, antitumor, mutation, hepatoprotective and reducing blood sugar and blood fat；Regulate immunology tremella polysaccharide and tremella polysaccharide spore can activate Turnover of Mouse Peritoneal Macrophages, increase its phagocytic activity；Humoral immunization。Tremella polysaccharide can promote that the hemolysin of normal mouse and the suppressed mice of immunologic function is formed；Impact on cellular immunization。Tremella polysaccharide has the LT effect of certain promotion, makes T lymphocyte and bone-marrow-derived lymphocyte all have increase；Also there is the effect of agglutinin, can the red thin race of coagulation, participate in the effect such as cytophagous activation and biophylaxis, improve nonspecific immunity function。
Lentinus Edodes: Lentinus Edodes is the basidiomycetes of Pleurotaceae, famous and precious edible one of the medicinal fungus of holding concurrently in the world, it contains multiple effective Pharmaceutical ingredients, and the lentinan that especially it contains is to have antiviral, antitumor, adjustment immunologic function and stimulate the functions such as interferon formation；The pharmacological action of lentinan is it is not direct aggression etiology, but by immune stimulatory cell maturation, differentiation and propagation, improves host body balance, reaches to recover and improve the host cell reactivity to lymphokine, hormone and other physiologically active factor。Therefore it is often biological response modifier by person。
Poria: Poria is On Polyporaceae, for one of Chinese medicine eight delicacies, nature and flavor are sweet, light, flat；GUIXIN, lung, spleen, kidney channel；There is the effects such as promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, tranquilizing by nourishing the heart。Have loose bowels for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool, irritability, the disease such as palpitation with fear insomnia。Poria main component has pachyman, fuling triterpene etc., modern pharmacology research show Poria there is immunomodulating, antitumor, protect the liver, antioxidation, antiinflammatory, antiviral, the multiple pharmacological effect such as diuresis。
Fructus Lycii: Fructus Lycii is plant of Solanaceae, its sweet in the mouth, property is put down。Return Liver Channel, kidney channel, lung meridian。Function: nourishing the liver, nourishing kidney, lung moistening。Cure mainly: caused by liver and kidney deficiency；Have a dizzy spell；Visually unclear；Soreness of the waist and knees；Impotence and seminal emission；Cough due to consumptive disease；Quench one's thirst taking fluids profusely, be famous and precious medical material and tonic。Modern study finds that Fructus Lycii main nutrient composition has lycium barbarum polysaccharide, essence fiber, glycine betaine, aminoacid etc.；There is promotion immunity, antioxidation, slow down aging, reduction blood glucose, promote the effects such as apoptosis of tumor cells, Antiradiation injury, blood fat reducing。
Hericium erinaceus (Bull. Ex Fr.) Pers.: be famous medicine-food two-purpose fungus。Hericium erinaceus (Bull. Ex Fr.) Pers. property is put down, sweet in the mouth, and favourable the five internal organs are aid digestion, and the effect such as nourish the body, and particularly to gastric ulcer, the patient such as duodenal ulcer and neurasthenia has good health-care effect。Hericium Erinaceus Polysaccharide is one of its main active, has the effects such as immunomodulating, antitumor, defying age, blood sugar lowering, blood fat reducing, mutation, radioprotective。
The Radix Astragali: the Radix Astragali is leguminous plant, has effect of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, expelling pus and toxin by strengthening QI, inducing diuresis to remove edema, expelling pus and promoting granulation。Modern pharmacological research shows, the Radix Astragali has enhancing human body immunity function, and heart tonifying blood pressure lowering, blood sugar lowering, diuresis, defying age, resisting fatigue, antitumor, antiviral, calmness, analgesia etc. act on。
Semen Nelumbinis: Semen Nelumbinis are the nutrient healths that China is traditional, sweet-puckery flavor, property are flat。Recording according to Compendium of Materia Medica, Semen Nelumbinis are laid one's heart bear effect of kidney, thick the intestines and stomach, controlling nocturnal emission with astringent drugs gas, tonifying deficiency, profit knowledge, tool nourishing the heart and kidney, invigorating the spleen to arrest diarrhea。Semen Nelumbinis contain the trace element such as starch, polysaccharide, protein, fat and calcium, phosphorus, ferrum, zinc, possibly together with alkaloids such as nuciferine, oxoushinsunine, liensinines。Oxoushinsunine, has the effect suppressing nasopharyngeal carcinoma, and liensinine has hypotensive effect。
Semen Euryales: begin to be loaded in Shennong's Herbal, it is classified as top grade, have another name called Caput Gallus domesticus, go through version " Chinese Pharmacopoeia " all on the books, for the dry mature kernal of nymphaeaceae plant Gorgon euryale, there is effect of supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, damp eliminating leukorrhagia stopping, cure mainly nocturnal emission, spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia。Have " in water Radix Ginseng " and the good reputation of " in water Arillus Longan ", be traditional Chinese crude drug and precious natural tonic。Modern study shows flavone and cyclic peptide, glucityl sterol compound etc.；There is antioxidation, regulate the effect of immunity。
Radix Codonopsis: be Campanulaceae, its sweet in the mouth, property is put down, and enters spleen, lung two warp, has invigorating the spleen and replenishing QI, the merit of the stomach function regulating that promotes the production of body fluid。Containing polysaccharide and the several amino acids constituting nutrient substance, multiple inorganic elements；Promoting blood and immunization of cell, Radix Codonopsis can improve the body resistivity to destructive stimulus, and Radix Codonopsis extract can strengthen the ability of peritoneal macrophage phagocytosis chicken red blood cell。
The present invention with Ganoderma, Hericium erinaceus (Bull. Ex Fr.) Pers. for monarch drug, stomach function regulating spleen invigorating, strengthening the body resistance, and the combination of ganoderan, Hericium Erinaceus Polysaccharide can significantly improve the vigor of macrophage, strengthens its phagocytic activity；With Tremella, Poria, Lentinus Edodes, the Radix Astragali, Semen Nelumbinis for ministerial drug, spleen invigorating eliminating dampness by diuresis, QI invigorating, and pachyman, tremella polysaccharide, lentinan, astragalus polysaccharides, Semen Nelumbinis polysaccharide etc. combine and can significantly improve a large amount of propagation that can promote immunocyte, cytokine such as interleukin 1, interleukin II, tumor necrosis factor is made to secrete in a large number；With Fructus Lycii, Radix Codonopsis, Semen Euryales for adjuvant drug QI invigorating YIN nourishing, and the combination of lycium barbarum polysaccharide, Radix Codonopsis polysaccharide, Semen Euryales flavone can significantly improve the raising body resistivity to destructive stimulus。All medicines share can regulate, strengthening the body resistance, spleen reinforcing stomach invigorating, qi and blood tonifying etc. can the immunologic function of enhancing body and resistances against diseases。
After medicine of the present invention configures according to component, can take directly as decoction decocting, corresponding dosage form can also be prepared into by the common process of pharmacy of Chinese materia medica, such as oral liquid, electuary, capsule or tablet etc., including effective ingredient, this effective ingredient is the extract of above-mentioned immunoregulatory Chinese medicine composition。Preferably, this extract is the water extract obtained by conventional decocting (being such as commonly performed twice water to carry)。Pharmaceutic adjuvant can be added as required。
Below in conjunction with object lesson, the present invention is further explained, but the present invention is not limited to this specific examples。
Embodiment 1
Formula: Ganoderma 50 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 50 parts, 50 parts of Tremella, 45 parts of Lentinus Edodes, 40 parts of Poria, the Radix Astragali 15 parts, 20 parts of Semen Nelumbinis, Fructus Lycii 20 parts, Radix Codonopsis 10 parts, Semen Euryales 20 parts。
Take ten tastes such as Ganoderma and add 12 times amount water；Infiltrate 1 hour；Decoct 2 hours；Filter；The another device of filtrate preserves；Filtering residue adds 10 times amount water；Decoct 2 hours；Filter；Collecting decoction；Being evaporated to relative density is 1.05；Cold preservation 48 hours；Take cold preservation liquid to be centrifuged；Boiling 10 minutes, cooling, titanium rod filters；Add water to quantitatively；Subpackage sterilizing, thus obtaining the product oral liquid。For mouthfeel more preferably, appropriate crystal sugar can be added in oral liquid。Consider diabetes patient colony, it is also possible to without crystal sugar。The present embodiment oral liquid (1ml is containing medical material 0.5g), crowd recommends daily intaking amount to be 30ml/60kgBW (i.e. 0.5ml/kgBW)。
Embodiment 2
Formula: Ganoderma 40 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 40 parts, 40 parts of Tremella, 30 parts of Lentinus Edodes, 30 parts of Poria, the Radix Astragali 10 parts, 10 parts of Semen Nelumbinis, Fructus Lycii 20 parts, Radix Codonopsis 10 parts, Semen Euryales 10 parts。
Preparation method is with embodiment 1。
Embodiment 3
Formula: Ganoderma 60 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 60 parts, 60 parts of Tremella, 50 parts of Lentinus Edodes, 50 parts of Poria, the Radix Astragali 30 parts, 30 parts of Semen Nelumbinis, Fructus Lycii 40 parts, Radix Codonopsis 30 parts, Semen Euryales 30 parts。
Preparation method is with embodiment 1。
Embodiment 4
Formula: Ganoderma 45 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 50 parts, 45 parts of Tremella, 35 parts of Lentinus Edodes, 40 parts of Poria, the Radix Astragali 20 parts, 15 parts of Semen Nelumbinis, Fructus Lycii 15 parts, Radix Codonopsis 15 parts, Semen Euryales 15 parts。
Preparation method is with embodiment 1。
Embodiment 5
Formula: Ganoderma 55 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 55 parts, 55 parts of Tremella, 45 parts of Lentinus Edodes, 45 parts of Poria, the Radix Astragali 25 parts, 25 parts of Semen Nelumbinis, Fructus Lycii 35 parts, Radix Codonopsis 25 parts, Semen Euryales 25 parts。
Preparation method is with embodiment 1。
Embodiment 6
Formula: Ganoderma 50 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 50 parts, 45 parts of Tremella, 30 parts of Lentinus Edodes, 50 parts of Poria, the Radix Astragali 25 parts, 15 parts of Semen Nelumbinis, Fructus Lycii 35 parts, Radix Codonopsis 15 parts, Semen Euryales 25 parts。
Preparation method is with embodiment 1。
Test example
Illustrate that medicine of the present invention strengthens the effect of immunologic function by animal experiment report。With the mice of immunologic hypofunction caused by hydrocortisone for animal subject model, using levamisole as positive control。
1. sample source and process
By each for the embodiment of the present invention 1 medical material according to proved recipe ratio compatibility, routine prepares water decoction, changes mice dosage into by adult's clinical application amount, and adjusting concentration is that large and small 2 dosage (being respectively equivalent to crude drug 1g/ml, 0.25g/ml) are standby。
2 animals
Kunming mice 50, male and female half and half, weight 18～22g, it is randomly divided into that Normal group, model group, levamisole positive controls and invention oral liquid be low, high dose group, often group 10。Normal group and model group gavage normal saline, 0.5mL/d, continuous 10d；Levamisole group gavage levamisole, 5mg/kg, continuous 10d；Invention oral liquid is low, the conventional water decoction of preparing of high dose group, 0.5mL/d, continuous 10d。Each group mice 4-7d subcutaneous injection hydrocortisone, 50mg/d, continuous 4d except Normal group。
3. macrophage phagocytosis of mice test
Each group mice last is administered next day, takes out peritoneal exudate cells after every lumbar injection 5% chicken red blood cells 1mL, 2h, the fixing dyeing of acetone-methanol (1: 1), measures macrophage phagocytic percentage rate and phagocytic index。
Phagocytic percentage=100 macrophage swallows macrophage number/100 macrophage × 100% of chicken red blood cell；Phagocytic index=100 macrophage swallows chicken red blood cell number/100 macrophage。
4. Oral Liquid On Mice immune organ of the present invention impact test
Next day is put to death animal in each group mice last administration, wins thymus and spleen, weighs quality, calculates Thymus and Spleen index。Thymus index or index and spleen index=Organ weight/weight × 100%。
5. the impact of mouse immune organ and immune factor is tested each group of mice last and is administered next day, plucks eyeball and takes blood, separate serum, surveys the content of IL-2, TNF-α, IFN-γ by test kit description method。
6. statistical procedures experimental data all adopts SPSS13.0 software to carry out statistical analysis, and between different groups, indicator difference adopts one factor analysis of variance。
7. result
Hydrocortisone is caused the impact of hypoimmunity mice Peritoneal Macrophage Phagocytosis and compares with Normal group by 7.1 oral liquids of the present invention, model group the phagocytosis ratio and phagocytosis index of macrophage significantly reduces (P < 0.05), it was shown that animal model modeling success；Comparing with model group, oral liquid of the present invention is low, high dose group mouse macrophage phagocytic rate and phagocytic index significantly raise (P < 0.05), it was shown that oral liquid of the present invention can improve macrophage phagocytosis of mice。In Table 1。
Table 1 oral liquid of the present invention hydrocortisone is caused hypoimmunity mice Peritoneal Macrophage Phagocytosis impact (N=10)
Note: * P < 0.05
Hydrocortisone is caused the impact of hypoimmunity mice Immune Organs Index and compares with Normal group by 7.2 oral liquids of the present invention, model group Thymus and Spleen index significantly reduces (P < 0.05), it was shown that the model modeling success of hydrocortisone induced mice immunologic hypofunction；Comparing with model group, oral liquid high dose group Thymus and Spleen index of the present invention significantly raises (P < 0.05), it was shown that oral liquid of the present invention has the effect improving immune organ function。In Table 2。
Table 2 oral liquid of the present invention hydrocortisone is caused hypoimmunity mice Immune Organs Index impact (N=10)
Note: * P < 0.05
Hydrocortisone is caused the impact of hypoimmunity mice immune factor by 7.3 oral liquids of the present invention
Comparing with model group, oral liquid high dose low, of the present invention all can promote that T cell is secreted, and makes the immune factors such as IL-2 in immunologic hypofunction mice serum caused by hydrocortisone, TNF-α and TNF-γ significantly raise (P < 0.05)。In Table 3。
Table 3 oral liquid of the present invention hydrocortisone is caused immune factor content in hypoimmunity mice serum impact (N=10)
Note: * P < 0.05
Clinical trial proves, various subhealth states and the disease because of immunity caused by abnormal is respectively provided with effect of well taking good care of by the medicine of the present invention。It addition, the raw material of the medicine of the present invention is the plant of integration of edible and medicinal herbs, no side effects, it it is a kind of well health promoting product simultaneously。

Claims (6)

1. an immunoregulatory Chinese medicine composition, it is characterized in that: calculate by weight, its formula is composed of the following components: Ganoderma 40～60 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 40～60 parts, 40～60 parts of Tremella, 30～50 parts of Lentinus Edodes, 30～50 parts of Poria, the Radix Astragali 10～30 parts, 10～30 parts of Semen Nelumbinis, Fructus Lycii 20～40 parts, Radix Codonopsis 10～30 parts, Semen Euryales 10～30 parts。
2. immunoregulatory Chinese medicine composition according to claim 1, it is characterized in that: calculate by weight, its formula is composed of the following components: Ganoderma 45～55 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 45～55 parts, 45～55 parts of Tremella, 35～45 parts of Lentinus Edodes, 35～45 parts of Poria, the Radix Astragali 15～25 parts, 15～25 parts of Semen Nelumbinis, Fructus Lycii 25～35 parts, Radix Codonopsis 15～25 parts, Semen Euryales 15～25 parts。
3. immunoregulatory Chinese medicine composition according to claim 1, it is characterized in that: calculate by weight, its formula is composed of the following components: Ganoderma 50 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 50 parts, 50 parts of Tremella, 45 parts of Lentinus Edodes, 40 parts of Poria, the Radix Astragali 15 parts, 20 parts of Semen Nelumbinis, Radix Codonopsis 10 parts, Fructus Lycii 20 parts, Semen Euryales 20 parts。
4. an immunoregulatory Chinese medicine preparation, including effective ingredient, this effective ingredient is the extract of immunoregulatory Chinese medicine composition described in claim 1,2 or 3。
5. immunoregulatory Chinese medicine preparation according to claim 4, it is characterised in that: the dosage form of described Chinese medicine preparation is oral liquid, electuary, capsule or tablet。
6. immunoregulatory Chinese medicine preparation according to claim 4, it is characterised in that: the extract of described Chinese medicine composition is water extract。
CN201610121170.4A 2016-03-03 2016-03-03 Immunoregulatory traditional Chinese medicine composition and preparation Pending CN105687480A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109078112A (en) * 2018-10-09 2018-12-25 河南知鑫生物科技有限公司 Improve tumour, inflammation class disease formula and preparation method thereof
CN110115356A (en) * 2019-06-06 2019-08-13 广州市美澳健生物科技有限公司 A kind of strengthen immunity and protection gastric mucosa composition and application method
CN115153016A (en) * 2021-04-06 2022-10-11 大连鑫玉龙海洋生物种业科技股份有限公司 Sea cucumber polypeptide chelated zinc oral liquid and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN101491334A (en) * 2009-02-19 2009-07-29 南方李锦记有限公司 Health food with immunity reinforcement function
CN102048154A (en) * 2009-11-10 2011-05-11 天津市百奥生物技术有限公司 Health protection food having function of regulating blood sugar and preparation method thereof
CN104887953A (en) * 2015-05-14 2015-09-09 邓学峰 Oral anti-aging paste formula

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN101491334A (en) * 2009-02-19 2009-07-29 南方李锦记有限公司 Health food with immunity reinforcement function
CN102048154A (en) * 2009-11-10 2011-05-11 天津市百奥生物技术有限公司 Health protection food having function of regulating blood sugar and preparation method thereof
CN104887953A (en) * 2015-05-14 2015-09-09 邓学峰 Oral anti-aging paste formula

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109078112A (en) * 2018-10-09 2018-12-25 河南知鑫生物科技有限公司 Improve tumour, inflammation class disease formula and preparation method thereof
CN110115356A (en) * 2019-06-06 2019-08-13 广州市美澳健生物科技有限公司 A kind of strengthen immunity and protection gastric mucosa composition and application method
CN115153016A (en) * 2021-04-06 2022-10-11 大连鑫玉龙海洋生物种业科技股份有限公司 Sea cucumber polypeptide chelated zinc oral liquid and preparation method thereof

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