CN102526456A - Health-care medicine formula capable of enhancing immunity and promoting sleep function - Google Patents
Health-care medicine formula capable of enhancing immunity and promoting sleep function Download PDFInfo
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Abstract
The invention relates to a health-care medicine formula capable of enhancing immunity and promoting the sleep function, which is prepared from the following raw materials in parts by weight: 6-15 parts of broccoli extract, 9-15 parts of poria cocos, 9-12 parts of spina date seed extract, 4.5-8 parts of lily, 3.6-10 parts of microcrystalline cellulose, 2.2-8 parts of sorbitol, 7.5-15 parts of mannite, 0.45-1 part of sucralose and 0.315-0.45 parts of magnesium stearate. According to the health-care medicine formula capable of enhancing the immunity and promoting the sleep function, the symptoms of insomnia and dreamful sleep of people can be improved to improve the health level of people and improve the quality of life of people with low immunity. The health-care medicine formula does not have side effect or adverse reaction. Because of adopting the modern preparation technology and an advanced quality control method, the product is safe and stable and has controllable quality.
Description
Technical field
The present invention relates to a kind of health medicine, relate in particular to a kind of enhancing immunity, hypnotic functional health pharmaceutical formulation.
Background technology
Along with the quickening of development of times and rhythm of life, the continuous development of society, the fierceness day by day of competition, the life stress that people face is also increasing.The insomnia problem that professional population often has each colony that begun to extend.Insomnia is meant to fall asleep and maybe can't keeps sleep state, causes not having enough sleep.Be weighed into again and sleep and keep sleep disorder (DIMS); Chinese medicine is called again: be insomnia, insomnia, must not crouch, the unable to close the eyes; Be often can not obtain a kind of disease that ortho sleep is a characteristic; For a variety of causes causes that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep are not enough or of poor quality etc., the common reason that causes having a sleepless night mainly contains environment reason, individual factors, body reason, Nervous and Mental Factors, emotional factor etc.According to Traditional Chinese medical theory, the reason of insomnia is mainly the internal organs disorder, especially the YIN nourishing function of the warming YANG function of the heart and kidney can not coordination, deficiency of qi and blood, imbalance of YIN and YANG etc.Not have sleep just not have health be the medical research personnel according in recent years to the neodoxy that latest result proposed of sleep study.The quality of sleep quality relates to normally carrying out of each item functional activity when waking up.Relevant research shows, but sleep produces outside the new vitality human body except allaying tiredness, also with the ability that improves immunity, resist the disease substantial connection is arranged.Sleep disorder then has a strong impact on quality of life.Reach the change of life style with the quickening pace of modern life, the sickness rate of sleep disorder increases gradually, and has become a major issue of the current medical circle of puzzlement.
Sleep disorder increases along with the increase at age, and the sickness rate in the old people is especially high.World Health Organization (WHO) proposes, and the over-65s person of developed country is the old people, developing country more than 60 years old the person be the old people.China more than 60 years old aging population with annual 3.2% speed increment.Foreign study finds that the prevalence rate of sleep disorder is 30%-40% among the old people.International spiritual and neurological foundation investigation demonstration in 2002 has 45% to have sleep disorder in the population of China, its middle-aged and elderly people accounts for 56.7%.In various sleep disorder, insomnia is modal one type, and it is meant starting of sleep and keeps the generation obstacle, is sleep quality or up a kind of subjective experience the less than normal demand.Secular insomnia, but the serious harm old people is physically and mentally healthy, also is simultaneously accident and the dead high risk factor that takes place.So how safe and reasonable ground uses the medicine of sleeping peacefully, and improves the physically and mentally healthy level of old people, has become the research focus of life sciences, people also can treat the effective proved recipe of safety economy of neurasthenia in continuous searching.
China is engaged in the research and the production of natural drug; Advantageous condition is arranged; The rarity of Traditional Chinese Medicine, it has clinical experience in several thousand, from present pharmaceutical research trend; Searching new drug or discovery guide are combined to thing and it are carried out the important content that structural modification is a drug development from natural product, add growth in the living standard and also make people that the quality of life has been had higher pursuit.Thereby pay attention to health more, pay attention to sleeper effect.Under this background, this prescription utilization high-tech means and with free of contamination pure natural animals and plants be aided with the enhancing immunity that other functional components are raw material, the health product of hypnotic function arise at the historic moment, and develop rapidly.
Summary of the invention
For solving the problems of the technologies described above, the present invention provides a kind of enhancing immunity, hypnotic functional health pharmaceutical formulation.
Enhancing immunity of the present invention, hypnotic functional health pharmaceutical formulation are processed by the raw material that comprises following parts by weight: Caulis et Folium Brassicae capitatae 6-15, Poria 9-15; Semen Ziziphi Spinosae extract 9-12, Bulbus Lilii 4.5-8, microcrystalline Cellulose 3.6-10; Sorbitol 2.2-8; Mannitol 7.5-15, sucralose 0.45-1, magnesium stearate 0.315-0.45.
The method for preparing of enhancing immunity of the present invention, hypnotic functional health medicine may further comprise the steps:
1) Poria 9-15 part, Bulbus Lilii 4.5-8 part are pulverized respectively, cross the 80-100 mesh sieve;
2) powder that step 1) is obtained mixes with the raw material of following parts by weight: Caulis et Folium Brassicae capitatae 6-15, Semen Ziziphi Spinosae extract 9-12, microcrystalline Cellulose 3.6-10; Sorbitol 2.2-8; Mannitol 7.5-15, sucralose 0.45-1, magnesium stearate 0.315-0.45; Incorporation time 45-50 minute;
3) will pass through step 2) mixture that obtains carries out tabletting, and control strip focuses within the inner quality standard, screens and inner packing again, carries out outer package then, at last by touchstone check warehouse-in.
Beneficial effect compared with prior art of the present invention is: enhancing immunity of the present invention, hypnotic functional health medicine can improve people's insomnia and dreamful sleep symptom; Improve people's health level; Improve immunocompromised person's quality of life, have no side effect and untoward reaction, and use modern preparation technique; Advanced method of quality control makes product accomplish safety, stable, quality controllable.
The specific embodiment
Below in conjunction with embodiment, specific embodiments of the invention describes in further detail.Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1
A kind of enhancing immunity, hypnotic functional health pharmaceutical formulation are processed by the raw material that comprises following weight (gram): Caulis et Folium Brassicae capitatae 15, Poria 10, Semen Ziziphi Spinosae extract 10; Bulbus Lilii 6, microcrystalline Cellulose 4, Sorbitol 5; Mannitol 8, sucralose 0.5, magnesium stearate 0.315.
The method for preparing of described enhancing immunity, hypnotic functional health medicine may further comprise the steps:
1) Poria 10 grams, Bulbus Lilii 6 grams are pulverized respectively, crossed the 80-100 mesh sieve;
2) powder that step 1) is obtained mixes with the raw material of following weight (gram): Caulis et Folium Brassicae capitatae 15, Semen Ziziphi Spinosae extract 10, microcrystalline Cellulose 4, Sorbitol 5, mannitol 8, sucralose 0.5, magnesium stearate 0.315; Incorporation time 45-50 minute;
3) will pass through step 2) mixture that obtains carries out tabletting, and control strip focuses within the inner quality standard, screens and inner packing again, carries out outer package then, at last by touchstone check warehouse-in.
Embodiment 2
A kind of enhancing immunity, hypnotic functional health pharmaceutical formulation are processed by the raw material that comprises following weight (gram): Caulis et Folium Brassicae capitatae 12, Poria 12, Semen Ziziphi Spinosae extract 12; Bulbus Lilii 4.5, microcrystalline Cellulose 3.6, Sorbitol 2.2; Mannitol 9, sucralose 1, magnesium stearate 0.45.
The method for preparing of described enhancing immunity, hypnotic functional health medicine is with embodiment 1.
Embodiment 3
A kind of enhancing immunity, hypnotic functional health pharmaceutical formulation are processed by the raw material that comprises following weight (gram): Caulis et Folium Brassicae capitatae 8, Poria 15, Semen Ziziphi Spinosae extract 11; Bulbus Lilii 8, microcrystalline Cellulose 9, Sorbitol 8; Mannitol 14, sucralose 0.8, magnesium stearate 0.4.
The method for preparing of described enhancing immunity, hypnotic functional health medicine is with embodiment 1.
Enhancing immunity of the present invention, hypnotic functional health medicine can improve insomniac's symptom; Improve people's health level; Improve insomniac's quality of life, have no side effect and untoward reaction, and use modern preparation technique; Advanced method of quality control makes product accomplish safety, stable, quality controllable.
Each component has following characteristics in enhancing immunity of the present invention, the hypnotic functional health pharmaceutical formulation:
1) Caulis et Folium Brassicae capitatae extracts from Caulis et Folium Brassicae capitatae, and Caulis et Folium Brassicae capitatae has another name called broccoli, blue and white Lay, sprouting broccoli etc., belongs to the mutation that the Cruciferae Caulis et Folium Brassicae campestris belongs to brassica specie, is one, the biennial herb plant, originates in Italy.Existing experiment proof Caulis et Folium Brassicae capitatae contains abundant cancer-resisting substance and can lower the formation to the mouse breast tumor, stops the activity of carcinogen.Scientist finds that the anti-cancer material in the brassicaceous vegetables such as Caulis et Folium Brassicae capitatae is the enzymatic hydrolysate or the derivant of thioglycoside, wherein isothiocyanate class most importantly.
Radix Raphani sulfur glycosides is a kind of of thioglycoside, extensively is present in the Caulis et Folium Brassicae capitatae, and Radix Raphani sulfur glycosides produces isothiocyanate through myrosinase enzymolysis or acid hydrolysis: sulforaphen.Sulforaphen is the strongest anti-cancer active matter of finding in the vegetable up to now, because of it finds to gain the name in Radix Raphani.The ocean son professor of Japan nutritionist good fortune man waits and passes through verification experimental verification: contained isothiocyanic acid ester derivant sulforaphen has treatment cancer and the effectiveness of killing leukocyte in the crucifers such as Brassica oleracea L.var.capitata and Caulis et Folium Brassicae capitatae, and this is to confirm that it has the effect of killing the leukaemia for the first time.Show that according to research Radix Raphani sulfur glycosides (3-methylsulfinyl acrylic thioglycoside) and 4-methylsulfinyl cyclobutenyl thioglycoside account for 78% of total glucosinolate content in the fresh Caulis et Folium Brassicae capitatae of freshly harvested.Under common content, Radix Raphani sulfur glycosides has important benefits with its catabolite to health, though Radix Raphani sulfur glycosides is not direct beneficial organism active substance, its hydrolyzate sulforaphen has the defencive function of enhances human body.
The relation of sulforaphen and immunocompetence mainly is: external existing research proof sulforaphen has the function that improves immunity.Experiment shows: gave BALB/c (4-6 age in week) mouse every day (every of 500ug/) feed sulforaphen in continuous 9 days; The total leukocyte counting was strengthened one times of amount in the 9th day; The quantity of medullary cell and esterase A positive cell has also increased by one times; The hemolysis plaque number obviously raises, and the synthetic antibody number obviously increases, and sulforaphen has also improved the activate the phagocytic capacity of peritoneal macrophage.Radix Raphani sulfur greatly reduces the higher leveled TNF-a that stimulates macrophage to produce by LPS (endotoxin) in addition.These results show that it is obvious that sulforaphen raising immunity and auxiliary obesity are improved the interior microenvironment effect of body.
Show through zoopery in addition: sulforaphen is remarkable in the effect of anti-tumor aspect.Sulforaphen is after continuously giving mouse high dose (μ mol/kg every days 100) feed in 4-5 days, and the activity that II separates toxenzyme mutually in mouse liver, lung, mammary gland, pancreas, stomach, small intestinal and colon all has raising.Munday etc. [9] have compared six kinds of abilities that ITCs induces QR (quinone reductase), GST Phase II such as (glutathione transferases) to separate toxenzyme in the mouse Different Organs.Test dose is μ mol/kg every days 40, and feeding is 5 days continuously.The result shows that all ITCs have shown the activity of in duodenum, stomach, bladder, inducing QR and GST, and wherein sulforaphen induces the activity of GST the strongest in duodenum and bladder, and the effect with bladder is the most remarkable again in all organs.Jackson discovers; F311 breast cancer cell to the BALB/c mouse when sulforaphen reaches 15nmol/L concentration has inhibitory action; Gave BALB/c mouse injection 15nmol/d in continuous 13 days, the sulforaphen of concentration, the F311 breast cancer cell of mouse reduces about 60%.
Above experimental data proof sulforaphen has significant raising immunity and antitumor efficacy; But because sulforaphen itself is very unstable; These article adopt its prerequisite Radix Raphani sulfur glycosides as main component, take Radix Raphani sulfur glycosides through the zoopery proof, become sulforaphen through enzymolysis in animal body; Can reach and directly take the identical effect of sulforaphen, and product is more stable.
These article any side effect and untoward reaction all do not occur through acute toxicology, nursing experiment in 30 days.These article adopt ethanol and water from the vegetable Caulis et Folium Brassicae capitatae, to extract in addition, do not have other pollution.The dosage that adopts is in usual Caulis et Folium Brassicae capitatae vegetable edible range.Show that this prescription is feasible, have good using value.
2) Poria, Poria are a kind of funguses that is grown in the pinaster root.Its property slightly sweet flavor has promoting diuresis to eliminate damp pathogen, the effect of invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, and disease curing range is quite extensive, is applicable to diseases such as edema oliguria, insufficiency of the spleen lack of appetite, irritability, insomnia and dreamful sleep, and is best to women and old people's tonic effect.Poria is classified as top grade in Shennong's Herbal, claims its " clothes are pacified soul and reposed not hungry prolonging life for a long time ".In recent years pharmacological research also proves, the pachyman that is rich in the Poria can the enhances human body immunologic function, can improve the resistance against diseases of human body, plays anti-and function in delaying senility.Containing hydroxyl pachyman (CMP) in the Poria, is one of Poria live part.The immunological enhancement of CMP: CMP can obviously strengthen the tumor-bearing mice phagocytosis of macrophages; Obviously increase mice spleen antibody secreting cell number (PFC) and special ABC number (SRFC); Obviously strengthen mice to the inductive delayed hypersensitivity of bovine serum albumin (BSA) (DTH); Obviously strengthen the growth of mice spleen T cell growth factor (TCGF), this possibly be one of mechanism of its enhance immunity answering and tumour inhibiting rate.CMP can induce people's blood lymphocyte to produce interferon one a (IFNa), interferon .7 (IFN.7), interleukin .2 (IL.2), interleukin .6 (IL-6), tumor necrosis factor .a (TNF.n) and grain. M-CSF (GM.CSF).Pharmacological testing proves that CMP can strengthen immune function of mice, shows that CMP is a kind of antineoplastic immune reinforcing agent.CMP intravenous injection dosage is 5,10,50mgkg.Mice spleen lymphocytes proliferation, peritoneal macrophage phagocytic function all had obvious facilitation at 1 o'clock, treated in vitro concentration 0.1～50t-tgnlL " time mice spleen lymphocytes proliferation had direct facilitation.The mice mixed lymphocyte reaction is also had obvious facilitation, and CMP also significantly strengthens the breeder reaction of ConA and the activatory mouse spleen lymphocyte of LPS and the effect that Turnover of Mouse Peritoneal Macrophages is engulfed dimethyl diaminophenazine chloride.Explain that the administration of CMP inside and outside all can significantly strengthen immune function of mice.CMP protects the liver and syngignoscism: CMP has hepatoprotective effect, the continuous intraperitoneal administration 5d of CMP100ms/kSd and Z00ms/kgd, and the mice serum glutamate pyruvate transaminase reduces by 27.32% and 41.03% respectively, with normal saline matched group ratio, P＜0.05 and P＜0.01.Press the continuous intraperitoneal administration 4d of 100rag/ksd before the rat liver partial excision operation, continuous again intraperitoneal administration 3d after the operation.Liver regeneration degree of rat and Liver Regeneration are heavy, and body weight increases by 73,29% and 18.95% respectively, with normal saline matched group ratio, and P＜0.01 and P＜0.001.CMP has syngignoscism, and the continuous intraperitoneal administration 7d of CMP momg/ksd can strengthen the inhibition of penthiobarbital to the mice maincenter, and the time that the mice righting reflex loss continues is 4.69 times of penthiobarbital matched group.With the penthiobarbital matched group than P＜O.05.So Poria extract can not only enhancing immunity, also can improve the quality of sleep.
3) Semen Ziziphi Spinosae, Ziziphi Spinosae is used the history in existing more than 2000 year as Chinese medicine, is mainly used in the treatment of cards such as deficiency of QI in middle-JIAO, weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, blood deficiency and yellow complexion, women's hysteria.Pharmacological research is found in recent years; Contain multiple bioactive substance in the Ziziphi Spinosae; Like Ziziphi Spinosae polysaccharide, flavonoid, saponins, triterpenes, alkaloids, cyclic adenosine monophosphate (cAMP), cycli phosphate crow glycosides (cGMP) etc.; Human body there is the plurality kinds of health care effect of curing the disease. Fructus Jujubae has effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, is patient's good health care nutriments such as weakness of the spleen and stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.See from clinical practice and to take Ziziphi Spinosae for the slight insomnia auxiliary treatment preferably of can yet be regarded as.
Jujuboside is one of main component of Semen Ziziphi Spinosae sedative-hypnotic effect, and the improvement of sleeping is had good effect.And, the improvement sleep effect of jujuboside is studied through the zoopery of jujuboside to mice sleep.
(1) jujuboside is tested the influence of the sleeping rate of subliminal hypnosis dosage barbital sodium mice: show like table 1 result; Jujuboside is to having injected sub-threshold dose crust sodium; With more than the righting reflex loss 30s as sleeping criterion, right influence than the sleeping rate of the mice of appropriate sodium, best with middle dose groups effect; It reflects and recovers to be the animal awakening, and righting reflex loss is a high dose group to recovering inferior during this period of time.
Table 1 jujuboside to each group mice medicine after the influence of sleep rate
(2) jujuboside is to the barbital sodium preclinical influence test of sleeping: show like table 2 result; The jujuboside of low dosage is to preclinical improvement effect of mice sleep and blank control group zero difference; The quadrature analysis test data group and the blank control group of middle dose groups and high dose table 2 ultrasonic extraction jujuboside more all have utmost point significant difference; Can find out, along with the increase of dosage, mice sleep shortening incubation period.
Table 2 jujuboside to each group mice administration after shadow noon of incubation period and the length of one's sleep
Annotate: compare with blank control group,
*P＜0.05,
*P＜0.01,
(3) jujuboside is to prolonging the influence test of the length of one's sleep of barbital sodium inducing mouse: show like table 2 result; Jujuboside is for the prolongation of the inductive sleep mouse sleep time of barbital sodium; The most obvious with high dose group; Secondly be middle dose groups, with blank control group utmost point significant difference arranged more all, low dose group and blank control group relatively have significant difference.Result of study shows that jujuboside has regulating action preferably for mice sleep, and to the influence of the sleeping rate of barbital sodium mice under the threshold, the jujuboside of middle high dose group has increase to the sleeping rate of mice, and low dose group is and the blank control group zero difference; To the preclinical influence of mice sleep, low dose group and blank control group be zero difference relatively, and there are utmost point significant difference in middle and high dose groups and blank group mice sleep incubation period, can significantly shorten mice sleep incubation period, and present certain dose-effect relationship; To the influence of the length of one's sleep of barbital sodium inducing mouse; Each dose groups all has the prolongation effect length of one's sleep to the barbital sodium inducing mouse; There are significant difference in low dose group and blank group on the length of one's sleep of mice; Relatively there are utmost point significant difference in middle and high dose groups and blank group, and present certain dose-effect relationship.
In sum, Semen Ziziphi Spinosae has obvious facilitation to sleep.
4) Bulbus Lilii extract, Bulbus Lilii are the medicine-food two-purpose conventional Chinese medicine, record the earliest in Shennong's Herbal and are listed as middle article.Chinese Pharmacopoeia record Bulbus Lilii has nourishing the lung to arrest cough, mind tranquilizing and the heart calming effect.Modern pharmacological research shows that Bulbus Lilii has effects such as YIN nourishing, lung moistening, tonifying the lung gas, cough-relieving, antiinflammatory, enhancing body immune function.In recent years, the domestic research report that effects such as many discovery Bulbus Lilii polysaccharide antitumor, immunostimulant are arranged makes the research of Bulbus Lilii polysaccharide class obtain gratifying progress.In order to clinical practice foundation to be provided, this experimental design emphasis adopts the new fresh Bulbus Lilii of single, contrasts with dry product medical material Bulbus Lilii, has carried out the experiment to the influence of pentobarbital sodium mouse sleep time.
Get mice random packet numbering, the administration group is gastric infusion respectively, and matched group is given the normal saline of equal volume; Behind the 30min; Lumbar injection pentobarbital sodium 35mg.kg-1, accurate recording administration time and righting reflex loss time, and with between this moment as the mice time for falling asleep.Related data is carried out design data method of inspection processing in groups.Experimental result is seen table 3.
The influence of table 3 pair nembutal mouse sleep time
Annotate:
*P＜0.05
Bulbus Lilii has syngignoscism preferably.Pentobarbital sodium is a central nervous depressant, and its threshold dose can produce sedative-hypnotic effect, makes the mice righting reflex loss, and tranquilizer can obviously be worked in coordination with this effect, shortens the mice time for falling asleep.Experimental result proves that Bulbus Lilii can significantly shorten the mice time for falling asleep, compares with the blank group, and BH-X (50) or BH-X (30) have than significance meaning (P＜0.05).
5) Sorbitol, mannitol, sucralose, magnesium stearate, microcrystalline Cellulose: consider that Caulis et Folium Brassicae capitatae, Poria, Semen Ziziphi Spinosae, Bulbus Lilii contain sugar and vitamin is higher and the taste medicine does not meet the characteristics of modern's custom; And the operability of the course of processing we selected food additive Sorbitol, mannitol, sucralose, magnesium stearate, microcrystalline Cellulose for use, show in " one one kinds of multi-functional macromolecular materials of microcrystalline Cellulose " literary composition of on " Guangzhou chemical industry " 1993 the 21st the 3rd phases of volume, delivering according to the Zhu Yu of Guangzhou Inst of Chemistry, Chinese Academy of Sciences qin, Tang Liegui, Pan Songhan: microcrystalline Cellulose can be used as antiplastering aid.The microcrystalline Cellulose addition meets GB2760 " food additive use sanitary standard " for 15% of prescription, and microcrystalline Cellulose toxicity property ADI does not do particular provisions (FAO/WHO, 1994); Sorbitol, mannitol, sucralose, magnesium stearate are corrected mouthfeel as sweetener, and addition meets GB2760 " food additive use sanitary standard " makes its whole prescription have more reasonability and science like this.
Each component is auxilliary mutually in whole prescription in enhancing immunity of the present invention, the hypnotic functional health pharmaceutical formulation deposits mutually; Bring out the best in each other; Make full side present effect preferably; Meet the composite reason of Chinese medicine, product has tangible enhancing immunity and hypnotic function through these article of function test proof.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from know-why of the present invention; Can also make some improvement and modification, these improve and modification also should be regarded as protection scope of the present invention.
Claims (1)
1. an enhancing immunity, hypnotic functional health pharmaceutical formulation is characterized in that, are processed by the raw material that comprises following parts by weight: Caulis et Folium Brassicae capitatae 6-15; Poria 9-15, Semen Ziziphi Spinosae extract 9-12, Bulbus Lilii 4.5-8; Microcrystalline Cellulose 3.6-10, Sorbitol 2.2-8, mannitol 7.5-15; Sucralose 0.45-1, magnesium stearate 0.315-0.45.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103751511A (en) * | 2014-02-13 | 2014-04-30 | 北京世纪中康医药科技有限公司 | Powder for improving sleeping |
| CN105076332A (en) * | 2015-09-08 | 2015-11-25 | 张丽雯 | Biscuit capable of reducing insomnia and making method thereof |
| CN116035215A (en) * | 2022-10-09 | 2023-05-02 | 上海耐欣科技有限公司 | Food composition with effects of soothing nerves and aiding sleep and preparation method thereof |
| CN116785374A (en) * | 2023-06-08 | 2023-09-22 | 成都中医药大学 | Traditional Chinese medicine effervescent tablet for soothing nerves and aiding sleep and preparation method thereof |
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| CN1626188A (en) * | 2004-08-09 | 2005-06-15 | 刘勇成 | Health product for enhancing immunity and soothing the nerves |
| CN101664428A (en) * | 2009-03-20 | 2010-03-10 | 宁波海逸生物科技有限公司 | Broccoli polyphenol capsules |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1626188A (en) * | 2004-08-09 | 2005-06-15 | 刘勇成 | Health product for enhancing immunity and soothing the nerves |
| CN101664428A (en) * | 2009-03-20 | 2010-03-10 | 宁波海逸生物科技有限公司 | Broccoli polyphenol capsules |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751511A (en) * | 2014-02-13 | 2014-04-30 | 北京世纪中康医药科技有限公司 | Powder for improving sleeping |
| CN105076332A (en) * | 2015-09-08 | 2015-11-25 | 张丽雯 | Biscuit capable of reducing insomnia and making method thereof |
| CN116035215A (en) * | 2022-10-09 | 2023-05-02 | 上海耐欣科技有限公司 | Food composition with effects of soothing nerves and aiding sleep and preparation method thereof |
| CN116785374A (en) * | 2023-06-08 | 2023-09-22 | 成都中医药大学 | Traditional Chinese medicine effervescent tablet for soothing nerves and aiding sleep and preparation method thereof |
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Application publication date: 20120704 |