CN100584363C - Traditional Chinese medicine oral liquid for treating damnification of immunity function after chemotherapy of cancer of the esophagus cancer patient - Google Patents
Traditional Chinese medicine oral liquid for treating damnification of immunity function after chemotherapy of cancer of the esophagus cancer patient Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal oral liquid for treating immunological function damage for patients of esophagus cancer after chemotherapy, wherein the oral liquid is prepared from the following raw materials (by weight proportion): ginseng 9-11%, astragalus root 18-22%, fine Chinese caterpillar fungus 8-10%, white atractylodes rhizome 9-11%, poria cocos wolf 14-16%, licorice root 8-10%, Chinese angelica root 11-13% and wolfberry fruit 14-16%.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine oral liquid for the treatment of the patient with esophageal carcinoma damnification of immunity function after chemotherapy.
Background technology
The esophageal carcinoma is China and one of modal malignant tumor in the world, and sickness rate has the trend that rises year by year in recent years, and its clinical manifestation is a primary symptom with carrying out property dysphagia, and pain or the like behind companion's breastbone or under the xiphoid-process belongs to the category of motherland's medical science " dysphagic " more.The pathogenesis of the esophageal carcinoma is not illustrated so far fully, Chinese medicine thinks that the occurrence cause of tumor mainly is owing to qi depression to blood stasis, phlegm-damp cohesion, evil poison pent up, just QI-insufficiency, deficient qi and blood etc. cause visceral dysfunction, so that the stasis of blood, expectorant, poison, void are assembled mutually, pent up with the passing of time, accumulation forms due to the lump.For the treatment of the esophageal carcinoma, effective method is exactly an excision, carries out chemotherapy or radiotherapy afterwards, and this method is widely used at home and abroad at present.
Accept to put, in the process of chemotherapy, medicine lacks specific selection to tumor cell, in kill cancer cell, normal cell also there is not unison damage, toxicity in various degree can appear in nearly all patient, as: loss of appetite, feel sick, vomiting, asthenia, weak, hemogram reduction, anemia etc., cause body damage, body constitution decline void, malnutrition, damnification of immunity function, even have the part patient can not adhere to treatment.Therefore the treatment that improves the patient immune function more and more is subject to people's attention in the patient with esophageal carcinoma Comprehensive Treatment.
Chinese medicine thinks that the toxic and side effects of chemotherapy, radiotherapy is that poison is evil and invades in the human body, and poison of drug gathers, and due to wasting QI-blood, the body fluid, and then causes the lifting imbalance of spleen and stomach function, and healthy energy is impaired, and QI and blood is two loses, and occurs that bone marrow depression, hemogram descend, damnification of immunity function.Carry out Comprehensive Treatment in conjunction with Chinese medicine and can alleviate above-mentioned toxic and side effects, make chemotherapy both can have the function of control postoperative recurrence and transfer, enhancing human body immunity again by carrying out in the original plan.In addition, tcm theory is thought, gas is the very strong cereal nutrient of a kind of vigor, the defence exopathogen is arranged, excite growth, warm blood vessels, many-sided functions such as meridians and adjusting metabolism, and think from the Chinese medical discrimination angle, the radiotherapy that the patient with esophageal carcinoma postoperative is carried out, the toxic and side effects that chemotherapy caused mostly is the transformation and transportation of the spleen and stomach imbalance, spleen master fortune, stomach the master receive, spleen rises stomach and falls, be the foundation of acquired constitution, therefore source of generating QI and blood adopts strengthening the body resistance, invigorating the spleen and benefiting QI, the Chinese prescription of nourishing the liver and kidney is to control radiotherapy, toxic and side effects after the chemotherapy has significance with improving the patient immune function and improving the prognosis effect.
Summary of the invention
The objective of the invention is to diagnostic techniques by modern medicine, in conjunction with basic theory of tcm, a kind of toxic and side effects that alleviates after patient with esophageal carcinoma chemotherapy, the radiotherapy is provided, improves a kind of Chinese medicine oral liquid for the treatment of the patient with esophageal carcinoma damnification of immunity function after chemotherapy of patient with esophageal carcinoma immunity.
For reaching above purpose, the technical solution adopted in the present invention is: this a kind of Chinese medicine oral liquid for the treatment of the patient with esophageal carcinoma damnification of immunity function after chemotherapy is characterized in that it is made up of the medicine material of following percentage by weight: Radix Ginseng 9-11%, Radix Astragali 18-22%, Cordyceps 8-10%, Rhizoma Atractylodis Macrocephalae 9-11%, Poria 14-16%, Radix Glycyrrhizae 8-10%, Radix Angelicae Sinensis 11-13%, Fructus Lycii 14-16%.Medicine material optimum weight percentage ratio in the Chinese medicine oral liquid of this treatment patient with esophageal carcinoma damnification of immunity function after chemotherapy is: Radix Ginseng 10%, the Radix Astragali 20%, Cordyceps 9%, the Rhizoma Atractylodis Macrocephalae 10%, Poria 15%, Radix Glycyrrhizae 9%, Radix Angelicae Sinensis 12%, Fructus Lycii 15%; Described Radix Glycyrrhizae, half is arranged is Radix Glycyrrhizae, half is a Radix Glycyrrhizae Preparata.Its preparation process is: 1, take by weighing each medicine material by above proportioning; 2, half of Radix Glycyrrhizae processed system, second half Radix Glycyrrhizae of making a living; 3, above all medicine material mixing are placed in the jacketed pan, add water and cover powder 2cm, soaked 10 minutes, heated and boiled 1.5 hours, cooled and filtered, filtering residue adds an amount of post-heating of water again and boiled 1 hour, refilters, and twice filtrate is merged; Filtering residue is added 70% ethanol to powder again and soaked 4 hours, squeeze and filter closes to such an extent that mix filtrate with above-mentioned filtrate; To mix filtrate again and heat back not heat up in a steamer to having the alcohol flavor, being concentrated into and contain crude drug in whole 2g in the 1ml medicinal liquid, and put cooled and filtered, fill is sealed in the bottle of 250ml, and 100 ℃ of flowing steam sterilizations promptly got this Chinese medicine oral liquid in 30 minutes, and this preparation process is a prior art.Instructions of taking: oral, chemotherapy begins to take the previous day, and every day three times, each 20ml serve on 21 days.Utilize the Chinese medicine oral liquid of this treatment patient with esophageal carcinoma damnification of immunity function after chemotherapy, having 102 examples tries out, from trial state, have 95 routine patients aspect peripheral blood immunoglobulin concentration, serum cytokines concentration, hemogram variation, the clinical state remarkable result being arranged all, obvious effective rate is 93.1%.
Beneficial effect of the present invention is: compare with injection Radix Astragali injection after the present esophageal carcinoma chemotherapy, aspect peripheral blood immunoglobulin, serum cytokines interleukin, hemogram, clinical symptoms, all show tangible curative effect, and have no side effect, and can reduce patient's medical expense.
The prescription pharmacology of this invention is:
Radix Ginseng: sweet, hardship, slightly warm in nature.Go into spleen, lung meridian.Effect: invigorating primordial QI, recuperating the depleted YANG to cure collapse-syndrome as emergency treatment, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst effect such as calm the nerves.Modern pharmacology shows, contains volatile oil, polysaccharide, aminoacid, pyrite and ginsenoside in the Radix Ginseng, has resisting fatigue, oxygen lack resistant function, also has effects such as heart tonifying, blood fat reducing, calmness, anticancer, sexual function improving;
The Radix Astragali: sweet, temperature is returned lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis detoxification, benefiting qi and raising yang, expelling pus and promoting granulation.Be mainly used in the disease of asthenia of pulmonosplenic qi and deficient qi and blood, and chronic nephritis, albuminuria etc.Be a kind of Chinese medicine of setting upright commonly used, the pharmaceutical chemistry analysis confirms, the Radix Astragali contains triterpenoid saponin derivant, chalcopyrite cpds, polysaccharide, several amino acids, trace element and vitamin etc., energy enhancing body resistance is regulated immunologic function, prevents from and alleviate virus to damage, promote the metabolism of water sodium, improve hypercoagulability, also have the effect of similar angiotensin converting enzyme inhibitor, unique kidney protective effect is arranged;
Cordyceps: sweet, flat, return lung, kidney channel.Effect: invigorating the lung and the kidney, hemostasia and dissipation blood stasis.Modern pharmacology shows and mainly contains cordycepic acid, carbohydrate, sugar, mineral etc. to have expansion bronchus, calmness, hypnotic effect, and various bacteria is had inhibitory action, has simultaneously to strengthen and regulate immunization;
The Rhizoma Atractylodis Macrocephalae: sweet, hardship, temperature.Return spleen, stomach warp.Effect: replenishing QI to invigorate the spleen, strengthening superficial resistance to stop perspiration, immunoregulation effect.Modern pharmacology shows that it not only has immunoregulation effect, also has tangible antioxidation, and enhancing body is removed the ability of free radical, reduces the damage of radical pair body.The single Rhizoma Atractylodis Macrocephalae can improve immunosuppressant animal splenocyte in vitro cultivation survival rate, prolongs lymphocyte life span, and the TH cell is obviously increased, improve TH/TS ratio, correct T cell distribution disturbance state, low IL-2 level is significantly improved, and can strengthen the expression of T lymphocytic cell surface IL-2R;
Poria: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Modern pharmacology shows and mainly contains pachyman, pachymic acid, lecithin etc.Have diuresis, analgesia, influence immunity, also can reduce gastric secretion and free acid content effect;
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Main chemical compositions is flavonoid alkaloid, polysaccharide etc.Pharmacological research confirms to have immunomodulating, antivirus action, promotes adrenal cortex secretion, antiinflammatory in addition, eliminates the phlegm, convulsion, detoxifcation, blood fat reducing, effect such as protects the liver;
Radix Angelicae Sinensis: acrid in the mouth, sweet, and slightly warm in nature.Go into the heart, liver, spleen three warps.Effect: enrich blood invigorate blood circulation, menstruction regulating and pain relieving, the function of moisturizing the strong bone of laxation, granulation promoting.Modern pharmacology studies show that, mainly contain chemical constituents such as volatile oil, saccharide, aminoacid, organic acid in the Radix Angelicae Sinensis, and further proved the Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling, effect such as the pain relieving of enriching blood, find also that simultaneously Radix Angelicae Sinensis has antiinflammatory, removes effects such as oxygen-derived free radicals, hepatic cholagogic, protection kidney, raise immunity;
Fructus Lycii: sweet, flat, go into liver, kidney channel.Effect: nourishing the liver and kidney, beneficial intensive culture blood, the removing nebula that makes eye bright, the lung cough-relieving disappears.Modern pharmacology studies confirm that, Fructus Lycii scalable body's immunity, the effect that can effectively suppress tumor growth and cell mutation, have aspects such as slow down aging, anti-fatty liver, blood lipid regulation and blood glucose.
Theory of Chinese medical science is thought radiotherapy, chemotherapy damage human righteousness, and having formed is the five internal organs gas, blood, the essence of core, the weakened body resistance syndrome of body fluid deficiency void with the deficiency of spleen and stomach, and has occurred the real syndromes of mark such as the stagnation of QI, expectorant be turbid on weakened body resistance basis for this.The Chinese medicine oral liquid of this treatment patient with esophageal carcinoma damnification of immunity function after chemotherapy, this crucial pathogenesis that links closely just, said medicine is combined, obtained remarkable efficacy.The modern pharmacology proof Radix Astragali can not only strengthen the cell function of normal body, T cell function in the time of also improving immunosuppressive condition, the activity of Rhizoma Atractylodis Macrocephalae energy anticancer propagation.Poria, Radix Glycyrrhizae have the effect of antitumor jointly.The Radix Astragali and Cordyceps are associated with, and improve function and adrenal cortex reinforcing function thereby have warming and recuperating the kidney-YANG, dispel hiding ailment said due to cold or exposure function to reach.Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Astragali, Radix Angelicae Sinensis have functions such as invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, blood circulation promoting and blood stasis dispelling, strengthening the body resistance, enhance immunity jointly.Fructus Lycii nourishing the liver and kidney QI invigorating, and Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.In addition, for solving patient with esophageal carcinoma spleen and stomach function weakness, the problem of a large amount of Chinese medicine decoction of can not taking food, its concentration extraction is made oral liquid, not only improve drug level, reduce patient's dose, be convenient to the stomach and esophageal carcinoma excision patient and take, and it is convenient that the patient is taken.In sum, the Chinese medicine oral liquid of this treatment patient with esophageal carcinoma damnification of immunity function after chemotherapy, not only have alleviate patient's postoperative stress with the opsonization of inflammatory reaction, also obvious enhancing body cellular immune function.
The clinical trial analysis data
1, source of data
Have 200 routine esophageal carcinoma patient with operation and participate in test, all from the patient with esophageal carcinoma that after Shandong Tumor Hospital's row radical excision operation, carries out chemotherapy between year June March to 2006 calendar year 2001, informed consent adheres to taking in accordance with regulations this Chinese medicine oral liquid or contrast medicine.(fluorouracil is 5-Fu:350mg/m to chemotherapy with the PF scheme
2, the 4th, 5 day; Cisplatin: 50mg/m
2, 1-5 days).
By be admitted to hospital sequencing numbering of patient, express according to random digit and to be divided into two groups: 102 examples are organized in treatment, 32～74 years old age, 58.4 years old mean age.When using traditional chemotherapy, take this Chinese medicine oral liquid; Matched group 98 examples, 33～73 years old age, 56.7 years old mean age.Use the chemotherapy regimen identical, give the Radix Astragali injection injection simultaneously with treatment group patient.All health check-up liver before the case chemotherapy, kidney cardiac function are normal, two groups of cases difference not statistically significant aspect age, sex, staging.
2, Therapeutic Method
The treatment group is taken this " Chinese medicine oral liquid of treatment patient with esophageal carcinoma damnification of immunity function after chemotherapy " when using traditional chemotherapeutic, and begins to take in preceding 1 day in chemotherapy, and every day 3 times, each 20ml serve on 21 days.The matched group patient uses the chemotherapy regimen identical with the treatment group, begins to give Radix Astragali injection 20ml in preceding 1 day in chemotherapy simultaneously, adds quiet of liquid, one day 1 time, injects 21 days.
Treatment group and matched group patient all the 1st, 7,15 day behind preceding 2 days of chemotherapy and end of chemotherapy detect indexs variations such as immune indexes peripheral blood immunoglobulin, blood cell factor interleukin and hemogram respectively, and at sensitivity and the toleration of chemotherapeutic period observation patient to chemotherapeutic, patients ' life quality (as symptom of digestive tract feel sick, situation such as vomiting), wherein the preceding 2 days detected value of chemotherapy as chemotherapy before normal value.
3, curative effect testing index
1. (concentration IgM) detects the peripheral blood immunoglobulin for IgG, IgA, adopts radio immunoassay; 2. serum cytokines interleukin IL-2, the concentration of IL-6 detects, and adopts kit measurement; 3. blood test is adopted in the variation of hemogram (hemoglobin [Hb], leukocyte [WBC], platelet [PLT]); 4. clinical symptoms and comparison: observation patient symptom of digestive tract is as performances such as nauseating, vomiting, loss of appetite.
4, efficacy result analysis
1. (IgG, IgA IgM) compare (seeing Table 1): as seen from Table 1, the treatment group is identical with the expression of the preceding peripheral blood immunoglobulin IgG of matched group patient chemotherapy, IgA, IgM for treatment group and matched group patient peripheral blood after chemotherapy immunoglobulin.The 1st day immunoglobulin IgG, IgA, IgM all have reduction in various degree after the chemotherapy, but matched group patient reduction is more obvious.Treatment group and matched group patient are when using this Chinese medicine oral liquid and Radix Astragali injection the 7th day and the 15th day respectively, peripheral blood Immunoglobulin IgA, IgG, IgM all have rise in various degree, but treatment group IgG, IgA, IgM rise amplitude are apparently higher than matched group.Therefore, this Chinese medicine oral liquid can alleviate the damage of chemotherapy to immunoglobulin, and the amplitude that immunoglobulin reduces in the blood is alleviated, and very fast recovery reaches normal level, increase patient's immunity.
Table 1 peripheral blood determination of immunoglobulin result comparison (mean+SD, g/L)
2. treatment group and the forward and backward serum cytokines IL-2 of matched group patient chemotherapy, IL-6 measurement result be (seeing Table 2) relatively: as seen from Table 2, treatment group and the preceding serum cytokines IL-2 of matched group patient chemotherapy, IL-6 expression are identical.The 1st day serum cytokines IL-2, IL-6 all have reduction in various degree after the chemotherapy, but that the matched group patient reduces is more obvious, and matched group IL-2 has on average reduced 91ng/L than treatment group, and IL-6 has on average reduced 40ng/L than treatment group.Treatment group and matched group patient are when using this Chinese medicine oral liquid and Radix Astragali injection the 7th day and the 15th day respectively, serum cytokines IL-2, IL-6 all have rise in various degree, but treatment group serum cytokines IL-2, IL-6 rise amplitude are apparently higher than matched group, and the effect of treatment group obviously is better than matched group.Therefore, this Chinese medicine oral liquid can alleviate the damage of chemotherapy to serum cytokines IL-2, IL-6, the amplitude that serum cytokines IL-2, IL-6 reduce in the blood is alleviated, and return to normal level quickly, increases the patient to antineoplastic immunity.
Table 2 serum cytokines IL-2, IL-6 measurement result be (ng/L) relatively
3. hemogram (hemoglobin [Hb], leukocyte [WBC], platelet [PLT]) change (seeing Table 3) before and after treatment group and the treatment of control group: as seen from Table 3, treatment group and the preceding hemoglobin of matched group patient chemotherapy, leukocyte, hematoblastic expression are identical.The 1st day hemoglobin, leukocyte, platelet all have reduction in various degree after the chemotherapy, but matched group patient reduction is more obvious.Treatment group and matched group patient are when using this Chinese medicine oral liquid and Radix Astragali injection the 7th day and the 15th day respectively, peripheral blood hemoglobin, leukocyte, platelet all have rise in various degree, but treatment group hemoglobin, leukocyte, platelet rise amplitude are apparently higher than matched group.Therefore, this Chinese medicine oral liquid can alleviate the damage of chemotherapy to hemocyte, and recovers the number of hemocyte quickly, the effect of performance rising hemoglobin, leukocyte, platelet counts.
Hemogram changes before and after the table 3 liang group patient chemotherapy
4. clinical symptoms relatively (seeing Table 4): as seen from Table 4, treatment group symptom such as weak, appetite descends, feel sick, effective routine number that vomiting improves is apparently higher than matched group.Illustrate that this Chinese medicine oral liquid can alleviate patient's side reaction symptom effectively, alleviates patient's misery.
The improvement of clinical symptoms relatively after the table 4 liang group patient chemotherapy
The specific embodiment
Embodiment 1:
Take by weighing Radix Ginseng 1000g, Radix Astragali 2000g, Cordyceps 900g, Rhizoma Atractylodis Macrocephalae 1000g, Poria 1500g, Radix Glycyrrhizae 900g, Radix Angelicae Sinensis 1200g, Fructus Lycii 1500g.Half 450g of Radix Glycyrrhizae is processed system, and 450g is a Radix Glycyrrhizae in addition.Above medicine material is mixed, place in the jacketed pan, add water and cover powder 2cm, soaked 10 minutes, heated and boiled 1.5 hours, cold filtration, filtering residue add water and boiled in right amount 1 hour, filter merging filtrate; Filtering residue reuse 70% soak with ethanol 4 hours, squeeze and filter merges each time filtrate, and reheat returns and heats up in a steamer to there not being the alcohol flavor, be concentrated into and contain crude drug in whole 2g in the 1ml medicinal liquid, cold filtration is loaded in the bottle of containing 250ml, seals, 100 ℃ of flowing steam sterilizations 30 minutes promptly get this Chinese medicine oral liquid, take fully.
Typical case case: Li Haixia on probation, esophageal carcinoma operation back chemotherapy begins preceding Chinese medicine oral liquid of taking this prescription in 1 day, and every day 3 times, each 20ml took 21 days.Preceding 2 days peripheral blood immunoglobulin IgG, IgA, the IgM of chemotherapy is respectively 11.86g/L, 2.21g/L, 1.97g/L; Serum cytokines IL-2 is 1299g/L, and IL-6 is 453g/L; Peripheral blood Hb127.5g/L, WBC 6.99 * 10
9/ L, PLT 237.8 * 10
9/ L.
Behind the end of chemotherapy the 1st day, in the stage that had the greatest impact by chemotherapy, reducing did not significantly appear in peripheral blood immunoglobulin, serum cytokines and hemogram, is respectively IgG 6.13g/L, IgA 1.46g/L, IgM 1.42g/L; IL-2 is 875g/L, and IL-6 is 299g/L; Hb 98.6g/L, WBC 3.45 * 10
9/ L, PLT 153.5 * 10
9/ L.Then obviously rose in the 7th day behind the end of chemotherapy, be respectively IgG 8.34g/L, IgA 1.73g/L, IgM1.71g/L, IL-2 are 945g/L, IL-6 is 397g/L, Hb110.3g/L, WBC 3.82 * 10
9/ L, PLT 187.2 * 10
9/ L.Behind the end of chemotherapy the 15th day, patient's immunoglobulin, serum cytokines IL-2 and IL-6, hemogram recovered normal level, use this Chinese medicine oral liquid after, the amplitude that immunoglobulin reduces reduces, and recovers very fast.Clinical symptoms no longer includes vomiting and feels sick.
Embodiment 2
Take by weighing Radix Ginseng 1100g, Radix Astragali 2100g, Cordyceps 800g, Rhizoma Atractylodis Macrocephalae 900g, Poria 1600g, Radix Glycyrrhizae 1000g, Radix Angelicae Sinensis 1100g, Fructus Lycii 1400g.Half 500g of Radix Glycyrrhizae is processed system.Produce step with embodiment 1.Instructions of taking is with embodiment 1.
Typical case case: Xie Fengxian on probation, the man, the beginning in preceding 1 day of esophageal carcinoma excision chemotherapy, by the Chinese medicine oral liquid that this programme is taken this prescription, preceding 2 days of chemotherapy, peripheral blood serum IgG 12.13g/L, IgA2.45g/L, IgM 1.84g/L; IL-2 is 1267g/L, and IL-6 is 476g/L; Hb 131.2g/L, WBC 6.56 * 10
9/ L, PLT 213.4 * 10
9/ L.Behind the end of chemotherapy the 1st day, be respectively IgG 6.31g/L, IgA 1.37g/L, IgM 1.39g/L; IL-2 is 868g/L, and IL-6 is 284g/L; Hb 102.3g/L, WBC 3.21 * 10
9/ L, PLT173.5 * 10
9/ L.
Then be clearly better in the 7th day behind the end of chemotherapy, be respectively IgG 8.57g/L, IgA 1.74g/L, IgM 1.68g/L, IL-2 are 987g/L, IL-6 is 375g/L, Hb113.5g/L, WBC 3.92 * 10
9/ L, PLT 194.2 * 10
9/ L.Behind the end of chemotherapy the 15th day, patient's immunoglobulin, serum cytokines IL-2 and IL-6, hemogram recovered normal level, use this Chinese medicine oral liquid after, the amplitude that immunoglobulin reduces reduces, and recovers very fast, patient's body constitution is significantly improved.Clinical symptoms no longer vomits, weak, also have nauseating once in a while.
Embodiment 3:
Take by weighing Radix Ginseng 900g, Radix Astragali 1800g, Cordyceps 1000g, Rhizoma Atractylodis Macrocephalae 1100g, Poria 1400g, Radix Glycyrrhizae 1000g, Radix Angelicae Sinensis 1300g, Fructus Lycii 1500g.Half 500g of Radix Glycyrrhizae is processed system.Produce step with embodiment 1.
Typical case case: Han Ling on probation, the woman, esophageal carcinoma cancer excision chemotherapy begins to take the traditional Chinese medicine mouth of this prescription and takes medicine in the time of preceding 1 day.Preceding 2 days of chemotherapy, peripheral blood serum IgG 11.56g/L, IgA2.12g/L, IgM 1.67g/L; IL-2 is 1176g/L, and IL-6 is 478g/L; Hb121.3g/L, WBC 6.54 * 10
9/ L, PLT 243.4 * 10
9/ L.Behind the end of chemotherapy the 1st day, be respectively IgG 6.01g/L, IgA1.31g/L, IgM 1.35g/L; IL-2 is 812g/L, and IL-6 is 259g/L; Hb 98.4g/L, WBC 3.06 * 10
9/ L, PLT 167.9 * 10
9/ L.
Then be clearly better in the 7th day behind the end of chemotherapy, be respectively IgG 8.95g/L, IgA1.68g/L, IgM 1.59g/L, IL-2 are 987g/L, IL-6 is 384g/L, Hb110.3g/L, WBC 3.72 * 10
9/ L, PLT 183.1 * 10
9/ L.Behind the end of chemotherapy the 15th day, patient's immunoglobulin, serum cytokines IL-2 and IL-6, hemogram recover normal level, use this Chinese medicine oral liquid after, the amplitude that immunoglobulin, IL-2 and IL-6 reduce reduces, and recover very fast, patient's body constitution is significantly improved.Nauseating, vomiting, weak that clinical symptoms no longer includes.
Claims (2)
1, a kind of Chinese medicine oral liquid for the treatment of the patient with esophageal carcinoma damnification of immunity function after chemotherapy, it is characterized in that it is made up of the medicine material of following percentage by weight: Radix Ginseng 9-11%, Radix Astragali 18-22%, Cordyceps 8-10%, Rhizoma Atractylodis Macrocephalae 9-11%, Poria 14-16%, Radix Glycyrrhizae 8-10%, Radix Angelicae Sinensis 11-13%, Fructus Lycii 14-16%, described Radix Glycyrrhizae, half is arranged is Radix Glycyrrhizae, and half is a Radix Glycyrrhizae Preparata; The preparation process of this Chinese medicine oral liquid is: (1), take by weighing each medicine material by above proportioning; (2), half of Radix Glycyrrhizae processed system, second half is a Radix Glycyrrhizae; (3), above all medicine material mixed place in the jacketed pan, add water and cover powder 2cm, soaked 10 minutes, heated and boiled 1.5 hours, cooled and filtered, filtering residue adds an amount of post-heating of water again and boiled 1 hour, refilters, with twice filtrate merging; Filtering residue is added 70% ethanol to powder again and soaked 4 hours, squeeze and filter closes to such an extent that mix filtrate with above-mentioned filtrate; To mix filtrate again and heat back not heat up in a steamer to having the alcohol flavor, being concentrated into and contain crude drug in whole 2g in the 1ml medicinal liquid, and put cooled and filtered, fill is sealed in the bottle of 250ml, and 100 ℃ of flowing steam sterilizations promptly got this Chinese medicine oral liquid in 30 minutes.
2, the Chinese medicine oral liquid of treatment patient with esophageal carcinoma damnification of immunity function after chemotherapy according to claim 1 is characterized in that the best proportioning value of described raw material weight percentage ratio is: Radix Ginseng 10%, the Radix Astragali 20%, Cordyceps 9%, the Rhizoma Atractylodis Macrocephalae 10%, Poria 15%, Radix Glycyrrhizae 9%, Radix Angelicae Sinensis 12%, Fructus Lycii 15%.
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