CN102178757B - Medicinal composition containing ferment caterpillar fungus powder and pears serving as raw materials - Google Patents
Medicinal composition containing ferment caterpillar fungus powder and pears serving as raw materials Download PDFInfo
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- CN102178757B CN102178757B CN2011101071034A CN201110107103A CN102178757B CN 102178757 B CN102178757 B CN 102178757B CN 2011101071034 A CN2011101071034 A CN 2011101071034A CN 201110107103 A CN201110107103 A CN 201110107103A CN 102178757 B CN102178757 B CN 102178757B
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- fermented cordyceps
- cordyceps powder
- bulbus fritillariae
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Abstract
The invention belongs to the technical field of medicaments, and discloses a medicinal composition containing ferment caterpillar fungus powder and pears serving as raw materials. The medicinal is characterized by comprising the following raw materials in parts by weight: 0.01 to 0.1 part of the ferment caterpillar fungus powder, 50 to 500 parts of pears, and 1 to 10 parts of one of unibract fritillary bulb, dwarf lilyturf turber, dendrobium nobile and purple perilla wrapped plum and/or one or more of hawthorn, liquorice, dried tangerine peel, lemon grass and pandan leaves. The medicinal composition has better treatment effect on deficiency-cold of lung.
Description
Technical field
The present invention relates to medical technical field, be specifically related to the pharmaceutical composition that a kind of raw material contains fermented Cordyceps powder and pears.
Fermented Cordyceps powder of the present invention be meant from natural cordyceps separate and arbitrary strain through artificial fermentation and mycelium powder, comprise the peacilomyce hepiahi bacterium powder, Hirsutella hepiali Chen et Shen powder, Cordyceps militaris (L.) Link. mycopowder.
Fermented Cordyceps powder can be used cordycepin, cordycepic acid, one or more of adenosine in the pharmaceutical composition of the present invention.
Pears of the present invention can be the pears powder, the extract of pears or Fructus Pyri thin paste.
Background technology
Cough is the reflex action of a kind of protectiveness of human body, can secretions in the respiratory tract and the extraneous foreign body of inhaling the people be excreted.The reason that causes coughing has a variety of, and wherein the cold cough of the deficiency of the lung is more common a kind of, how to be attacked by heresy of wind and cold; In strongly fragrant lung qi, lung qi obstruction and cause that expelling wind and cold, lung qi dispersing cough-relieving are adopted in traditional treatment more; Promptly use the medicine of relieving cough and asthma, such as Chinese medicines such as Pandan Leaves, Bulbus Fritillariae Cirrhosae, Semen Armeniacae Amarum, Radix Glycyrrhizae, Flos Farfarae, Radix Asteris, the Radixs Stemonae, though said medicine or its compositions can reach certain therapeutic effect; But the cause of disease-battalion that does not take into full account the cold cough of the deficiency of the lung defends not normal; Therefore, the cold cough of the treatment deficiency of the lung should add the medicine that improves immunity and can better treat above-mentioned disease on the said medicine basis.
It is the medicine of raw material that Chinese patent 200510118228.1 discloses with fermented Cordyceps powder, Folium Eriobotryae, Bulbus Fritillariae Cirrhosae; Though this medicine considers from deficiency of the lung cause of disease angle, on the basis of Pandan Leaves, Bulbus Fritillariae Cirrhosae, add fermented Cordyceps powder in the hope of can improving patient's immunity, whether the combination that this compatibility of drugs does not take into full account fermented Cordyceps powder and Pandan Leaves, Bulbus Fritillariae Cirrhosae is excellent effect; Therefore; Need further further investigation, obtain the drug effect better medicament, be patient and clinical service.
Summary of the invention
For these reasons, the applicant from the medicine of numerous raising immunity, optimizes compositionss such as fermented Cordyceps powder and Bulbus Fritillariae Cirrhosae, pears through discovering, obtains new pharmaceutical composition, and this pharmaceutical composition is trembled with fear to the deficiency of the lung and had better therapeutical effect.
The present invention realizes through following technical proposals.
A kind of raw material contains the pharmaceutical composition of fermented Cordyceps powder and pears, it is characterized in that the drug regimen raw material is a fermented Cordyceps powder 0.01-0.1 weight portion, pears 50-500 weight portion.
Pharmaceutical composition also comprises Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Herba Dendrobii, a kind of 1-5 weight portion in the SUGUOMEI.
Pharmaceutical composition also comprises Fructus Crataegi, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Herba Cymbopogonis Citrari, one or more 1-10 weight portions of Pandan Leaves.
Wherein pharmaceutical composition can also add crystal sugar, chinese cymbidium, Fructus Citri, rose candy, Sweet-scented Osmanthus, maltose, glucose or Fructus Mume.
The drug regimen raw material is a fermented Cordyceps powder 0.01-1 weight portion, pears 50-500 weight portion, Bulbus Fritillariae Cirrhosae 1-5 weight portion, Pandan Leaves 1-10 weight portion, crystal sugar.
The wherein pharmaceutical preparation of preparation of pharmaceutical compositions or food.
Wherein the pharmaceutical preparation of preparation of pharmaceutical compositions or food are tablet, granule, pill, oral liquid or capsule.
The beverage of preparation of pharmaceutical compositions wherein.
Fermented Cordyceps powder of the present invention be meant from natural cordyceps separate and arbitrary strain through artificial fermentation and mycelium powder, comprise the peacilomyce hepiahi bacterium powder, Hirsutella hepiali Chen et Shen powder, Cordyceps militaris (L.) Link. mycopowder.
Fermented Cordyceps powder can be used cordycepin, cordycepic acid, fermented Cordyceps powder, one or more of adenosine in the pharmaceutical composition of the present invention.
Pears of the present invention can be the pears powder, the extract of pears or Fructus Pyri thin paste.
One, optimization test
Trial drug:
1 group of medicine: fermented Cordyceps powder 3g, Bulbus Fritillariae Cirrhosae 8g;
2 groups of medicines: ginseng polysaccharide 50mg, Pandan Leaves 8g, Bulbus Fritillariae Cirrhosae 5g, pears 200g;
3 groups of medicines: astragalus polysaccharides 50mg, Pandan Leaves 8g, Bulbus Fritillariae Cirrhosae 5g, pears 200g;
4 groups of medicines: LBP 50mg, Pandan Leaves 8g, Bulbus Fritillariae Cirrhosae 5g, pears 200g;
5 groups of medicines: lentinan 50mg, Pandan Leaves 8g, Bulbus Fritillariae Cirrhosae 5g, pears 200g;
6 groups of medicines: fermented Cordyceps powder 50mg, Pandan Leaves 8g, Bulbus Fritillariae Cirrhosae 5g, pears 200g;
Test method: get body weight 20-30g mice, male and female half and half, random packet, 10 every group, 1 group of dosage of medicine is 2.7g/kg; Gastric infusion, every day 1 time, totally 7 days, 7 groups of dosages of 2 groups-medicine of medicine were 2.5g/kg, gastric infusion; Every day 1 time, totally 7 days, after the last administration 1 hour, each only organized lumbar injection 0.5% phenol red solution 0.5ml/, after 30 minutes; Put to death mice, separate trachea, use 5% sodium bicarbonate solution 0 then, 5ml; Irrigating solution is collected in lavation 3 times, detects at 500nm with the spectrophotometer of U.S. Hash company, and result of the test is seen table 1:
Table 1 different pharmaceutical phlegm-dispelling functions
Annotate: compare * P＜0.05 for 1 group with test; Compare ##P＜0.01 for 3 groups with test.
Conclusion (of pressure testing): above-mentioned experiment shows, with fermented Cordyceps powder and Pandan Leaves, Bulbus Fritillariae Cirrhosae compatibility, adds pears, has better pharmacological effect, proves absolutely that medicine material combination of the present invention is significant.
Two, the real test of pharmacology
Test 1 antitussive effect
Trial drug:
1 group of medicine: fermented Cordyceps powder 10mg, Pandan Leaves 1g, Bulbus Fritillariae Cirrhosae 1g, pears 50g;
2 groups of medicines: fermented Cordyceps powder 100mg, Pandan Leaves 10g, Bulbus Fritillariae Cirrhosae 5g, pears 500g;
3 groups of medicines: fermented Cordyceps powder 30mg, Pandan Leaves 9g, Bulbus Fritillariae Cirrhosae 2g, pears 450g;
4 groups of medicines: fermented Cordyceps powder 90mg, Pandan Leaves 2g, Bulbus Fritillariae Cirrhosae 4g, pears 60g;
5 groups of medicines: fermented Cordyceps powder 60mg, Pandan Leaves 5g, Bulbus Fritillariae Cirrhosae 2.5g, pears 250g;
6 groups of medicines: fermented Cordyceps powder 40g, Bulbus Fritillariae Cirrhosae 12g, Folium Eriobotryae 140g
Experimental animal: Kunming mouse, 20-25g, male and female half and half.
Test method: get mice, random packet: blank group, administration group, the blank group gives normal saline, gastric infusion; Every day 1 time, continuous 7 days, administration group gastric infusion, dosage 2.5g/kg; Continuous 7 days, last administration 1 was as a child sprayed to cause under 0.3-0.4 air pressure with 25% ammonia and is coughed; Sprayed for 5 seconds, the cough latent period and the number of times of coughing in 2 minutes of record mice, result of the test is seen table 2:
Table 2 medicine of the present invention is to the mice antitussive effect
Annotate: compare ##P＜0.01, #P＜0.05 with the normal saline group; Compare Δ P＜0.05 for 6 groups with test.
Test 2
Vivo bacteria corrosion action to the mouse infection model is observed
Experimental animal: Kunming mouse (18～22g), before the experiment, equal one week of breeding observing of each animal.Infection bacteria species: staphylococcus aureus all is clinical isolating pathogenic bacterium.
Trial drug:
1 group of medicine: fermented Cordyceps powder 60g, Folium Eriobotryae 180g, Bulbus Fritillariae Cirrhosae 8g;
2 groups of medicines: cordycepic acid 50mg, Pandan Leaves 2g, Bulbus Fritillariae Cirrhosae 5g, pears 200g;
Experimental technique:
(1) preparation of bacterium liquid: with clinical isolating typical gold Staphylococcus aureus be inoculated in the Carnis Bovis seu Bubali cream soup body culture test tube, in 37 ℃ of incubators, cultivate 18h.The bacterium liquid of this cultivation is used the turbidimetry for Determination bacterial concentration, add 5% yeast mixture doubling dilution again and become variable concentrations.
(2) get the healthy Kunming mouse of body weight 18～22g, male and female half and half (female unpregnancy), random pair divides into groups, gastric infusion, dosage is 2.5g/kg, administration 5d, the blank group is irritated stomach isometric(al) normal saline.With administration in the 5th day after 30 minutes, every mouse peritoneal injection staphylococcus aureus 9.5 * 10
6CFU/ml, 0.5ml.Equal conditions is raised, and continues administration 7d.Every day, the dead mouse number respectively organized in record.The result sees table 3.
The vivo bacteria corrosion action of table 3 pair mouse infection model is observed
Annotate: compare ##P＜0.01 with blank control group; Compare Δ P＜0.05 for 1 group with medicine
Conclusion (of pressure testing): above-mentioned pharmacological testing further specifies, and the combination of medicine material of the present invention has the effect of good clearing away lung-heat to relieve cough.
Three, preparation embodiment
Embodiment 1
Fermented Cordyceps powder 0.01g, Pandan Leaves 1g, Bulbus Fritillariae Cirrhosae 1g, pears 50g, Mel is an amount of;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage.
Embodiment 2
Fermented Cordyceps powder 0.1g, Pandan Leaves 10g, Bulbus Fritillariae Cirrhosae 5g, pears 500g, chitosan is an amount of;
To be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage.
Embodiment 3
Fermented Cordyceps powder 0.02g, Pandan Leaves 9g, Bulbus Fritillariae Cirrhosae 1.5g, pears 480g, Mel is an amount of;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage
Embodiment 4
Fermented Cordyceps powder 0.09g, Pandan Leaves 2g, Bulbus Fritillariae Cirrhosae 4.5g, pears 60g, crystal sugar is an amount of;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage
Embodiment 5
Fermented Cordyceps powder 0.06g, Pandan Leaves 4g, Bulbus Fritillariae Cirrhosae 3g, pears 245g;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage.
Embodiment 6
Fermented Cordyceps powder 0.08g, Pandan Leaves 3g, Bulbus Fritillariae Cirrhosae 5g, pears 450g;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage.
Embodiment 7
Cordycepic acid 0.01g, Pandan Leaves 1g, Bulbus Fritillariae Cirrhosae 1g, pears 50g, Mel is an amount of;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage.
Embodiment 8
Cordycepic acid 0.1g, Pandan Leaves 10g, Bulbus Fritillariae Cirrhosae 5g, pears 500g, chitosan is an amount of;
To be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage.
Embodiment 9
Cordycepin 0.02g, Pandan Leaves 9g, Radix Ophiopogonis 1.5g, pears 480g;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage
Embodiment 10
Fermented Cordyceps powder 0.09g, Pandan Leaves 2g, Radix Glycyrrhizae 6g, Herba Dendrobii 4.5g, pears 60g;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage
Embodiment 11
Fermented Cordyceps powder 0.06g, Pandan Leaves 4g, Bulbus Fritillariae Cirrhosae 3g, pears 245g;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage.
Embodiment 12
Fermented Cordyceps powder 0.08g, Pandan Leaves 1g, Fructus Crataegi 3g, Pericarpium Citri Reticulatae 4g, Bulbus Fritillariae Cirrhosae 5g, pears 450g;
Be prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Perhaps the method for preparing according to conventional beverage is prepared into beverage
Claims (3)
1. a raw material contains the pharmaceutical composition of fermented Cordyceps powder and pears, it is characterized in that pharmaceutical composition comprises fermented Cordyceps powder 0.01-0.1 weight portion, pears 50-500 weight portion.
2. a kind of raw material according to claim 1 contains the pharmaceutical composition of fermented Cordyceps powder and pears, and pharmaceutical composition also comprises Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Herba Dendrobii, a kind of 1-5 weight portion in the SUGUOMEI.
3. a kind of raw material according to claim 1 and 2 contains the pharmaceutical composition of fermented Cordyceps powder and pears, and pharmaceutical composition also comprises Fructus Crataegi, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Herba Cymbopogonis Citrari, one or more 1-10 weight portions of Pandan Leaves.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101071034A CN102178757B (en) | 2011-04-28 | 2011-04-28 | Medicinal composition containing ferment caterpillar fungus powder and pears serving as raw materials |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101071034A CN102178757B (en) | 2011-04-28 | 2011-04-28 | Medicinal composition containing ferment caterpillar fungus powder and pears serving as raw materials |
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| Publication Number | Publication Date |
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| CN102178757A CN102178757A (en) | 2011-09-14 |
| CN102178757B true CN102178757B (en) | 2012-10-31 |
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| CN108850944B (en) * | 2018-07-12 | 2020-10-02 | 河南省农业科学院园艺研究所 | Processing method of natural pear syrup |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456204A (en) * | 2003-01-03 | 2003-11-19 | 江西南昌桑海制药厂 | Oral liquid for tonifying Qi and kidney |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101953985A (en) * | 2010-10-12 | 2011-01-26 | 郭景龙 | Drug with function of removing heat from lung to relieve cough |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1456204A (en) * | 2003-01-03 | 2003-11-19 | 江西南昌桑海制药厂 | Oral liquid for tonifying Qi and kidney |
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Granted publication date: 20121031 Termination date: 20130428 |