CN101912575B - External medicament for treating painful swelling of joints and gout diseases and preparation process thereof - Google Patents
External medicament for treating painful swelling of joints and gout diseases and preparation process thereof Download PDFInfo
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Abstract
The invention discloses an external medicament for treating painful swelling of joints and gout diseases, which is prepared from the following raw materials: kelp, bletilla, radices trichosanthis, seaweed, Chinese violet, lightyellow sophora root, golden cypress, baical skullcap root, common selfheal fruit-spike, lychee seed, cherokee rose fruit, cape jasmine, common andrographis herb, paris root, common burreed rhizome, rhubarb, curcuma zedoary, akebiaquinata, turmeric and borneol. The external medicament is prepared from natural traditional Chinese medicines serving as raw materials, and can be prepared into powder, paste, spray, emulsion or cream by a conventional preparation method for Chinese medicinal preparations. The medicament is preferably powder, and has the advantages of remarkable and stable curative effect without toxic or side effect, convenient use, simple and convenient preparation and the like.
Description
Technical field
The present invention relates to a kind of external used medicine of treating arthralgia and gout, particularly relating to a kind of is the treatment arthralgia processed of raw material and the external used medicine and the preparation technology of gout with the natural Chinese medicine.
Background technology
Arthralgia and gout are the osteoarticular commonly encountered diseases of mankind nowadays, frequently-occurring disease, are the world-class especially difficult disease of osteoarthrosis a kind of chronic noninfective diseases associated with inflammation, particularly gout.Mostly its clinical manifestation symptom is: one or more arthralgia, hyperemia, deformity, heating, rubescent, the enlargement in surface; Dysfunction etc.; Modern medicine does not still have specific medicament; More lack external medication, gout is many to carry out acid-base neutralization or anti-inflammatory analgetic treatment with alkali electroless medicine or adrenocortical hormone.The patient is difficult to accept hormone and chemicals to the toxic and side effects of human body, more is ready to take the Chinese medicine external treatment.
The existing external used medicine that is used to treat arthralgia, gout mainly contains active wine, SHANGSHI ZHITONG GAO etc. on the market, but all there are defectives such as curative effect is remarkable inadequately to some extent in these medicines.
Summary of the invention
The object of the invention just is to overcome the deficiency of prior art, and providing a kind of is the treatment arthralgia processed of raw material and the external used medicine and the preparation technology of gout with Chinese medicine, and this curative effect of medication is remarkable; External use; Have no side effect, the use aspect, simple for production.
The objective of the invention is to realize through following technical scheme: the external used medicine of treatment arthralgia and gout, process by following natural Chinese medicine raw material in this external used medicine of weight proportion: Thallus Laminariae (Thallus Eckloniae) 12-18, Pseudobulbus Bletillae (Rhizoma Bletillae) 9-15, Radix Trichosanthis 9-15, Sargassum 12-18; Herba Violae 15-30, Radix Sophorae Flavescentis 15-30, Cortex Phellodendri 21-30, Radix Scutellariae 9-15; Spica Prunellae 30-45, Semen Litchi 12-18, Fructus Rosae Laevigatae 21-30, Fructus Gardeniae 12-18; Herba Andrographis 30-45, Rhizoma Paridis 15-30, triangular 12-18, Radix Et Rhizoma Rhei 6-10; Rhizoma Curcumae 12-18, Caulis Akebiae 15-20, Rhizoma Curcumae Longae 12-18, Borneolum Syntheticum 6-9.
Optimum, this external used medicine is processed by following Chinese medicine raw materials by weight proportion:
Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23, Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15, Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15, Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8.
The external used medicine of treatment arthralgia of the present invention and gout can adopt the conventional formulation method of Chinese medicine preparation to be prepared into any suitable clinical external preparation, for example can be powder, unguentum, Emulsion, cream or spray.
The step of external used medicine for preparing this treatment arthralgia and gout is following:
(1) take by weighing each raw material by following formula ratio:
Thallus Laminariae (Thallus Eckloniae) 12-18, Pseudobulbus Bletillae (Rhizoma Bletillae) 9-15, Radix Trichosanthis 9-15, Sargassum 12-18, Herba Violae 15-30; Radix Sophorae Flavescentis 15-30, Cortex Phellodendri 21-30, Radix Scutellariae 9-15, Spica Prunellae 30-45, Semen Litchi 12-18; Fructus Rosae Laevigatae 21-30, Fructus Gardeniae 12-18, Herba Andrographis 30-45, Rhizoma Paridis 15-30, triangular 12-18; Radix Et Rhizoma Rhei 6-10, Rhizoma Curcumae 12-18, Caulis Akebiae 15-20, Rhizoma Curcumae Longae 12-18, Borneolum Syntheticum 6-9;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei are total to Six-element decocte with water 2 times, each one to two hour, relative density 1.30 to 1.32 when collecting decoction, filtration, filtrating were concentrated into 60 ℃, got I;
(5) with above-mentioned fine powder and I mixing, drying becomes powder, unguentum, spray, Emulsion or cream with pharmaceutically acceptable preparing carriers.
The preparation technology of the external used medicine of treatment arthralgia of the present invention and gout, its step is following:
(1) takes by weighing each raw material by following weight ratio: Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23; Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15; Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15; Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) with totally six decocte with water 2 times of above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei, each one to two hour, merge and decoct, filter, relative density 1.30 to 1.32 when filtrating is concentrated into 60 ℃, I;
(5) with above-mentioned fine powder and I mixing, drying was pulverized 120 mesh sieves and was prepared into powder.
The present invention provides the external used medicine of treatment arthralgia and gout, is that raw material is processed with Chinese medicine, has evident in efficacyly, has no side effect lamp advantage easy to use and easy to make.
The specific embodiment
Embodiment 1
A kind of preparation of powder of external used medicine of treating arthralgia and gout:
(1) take by weighing each raw material by following weight ratio:
Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23, Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15, Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15, Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) with totally six decocte with water 2 times of above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei, each one to two hour, merge and decoct, filter, relative density 1.30 to 1.32 when filtrating is concentrated into 60 ℃, I;
(5) with above-mentioned fine powder and I mixing, drying was pulverized 120 mesh sieves and was prepared into powder.
Embodiment 2
A kind of preparation of unguentum of external used medicine of treating arthralgia and gout:
Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23, Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15, Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15, Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) with totally six decocte with water 2 times of above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei, each one to two hour, merge and decoct, filter, relative density 1.30 to 1.32 when filtrating is concentrated into 60 ℃, I;
(5) with above-mentioned fine powder and I mixing, drying is prepared into unguentum by general unguentum method for making.
Embodiment 3
A kind of preparation of Emulsion of external used medicine of treating arthralgia and gout:
Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23, Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15, Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15, Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) with totally six decocte with water 2 times of above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei, each one to two hour, merge and decoct, filter, relative density 1.30 to 1.32 when filtrating is concentrated into 60 ℃, I;
(5) with above-mentioned fine powder and I mixing, drying is prepared into Emulsion by the method for making of general Emulsion.
Embodiment 4
A kind of preparation of cream of external used medicine of treating arthralgia and gout:
Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23, Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15, Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15, Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) with totally six decocte with water 2 times of above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei, each one to two hour, merge and decoct, filter, relative density 1.30 to 1.32 when filtrating is concentrated into 60 ℃, I;
(5) with above-mentioned fine powder and I mixing, drying is prepared into cream by the method for making of general cream.
Embodiment 5
A kind of preparation of spray of external used medicine of treating arthralgia and gout:
Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23, Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15, Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15, Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) with totally six decocte with water 2 times of above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei, each one to two hour, merge and decoct, filter, relative density 1.30 to 1.32 when filtrating is concentrated into 60 ℃, I;
(5) with above-mentioned fine powder and I mixing, drying is prepared into spray by the method for making of general spray.
The clinical observation test of external used medicine according to the invention;
(1) physical data: accept onlooker totally 3660 for medical treatment, the age is at 2-85 between year.
(2) severity extent
Gout then pathology is longer, the swollen sharp ache of heat, and surperficial glow shows effect repeatedly, and very joint deformity or gout calculus appear in the person, starve blood examination blood count uric acid index and are higher than 430.This is the fundamental difference of gout and other arthralgia, and the contact of the two then disease gene all centers on around the joint ill.
(3) Therapeutic Method: the area at dosage of the present invention and dosage form and pathological changes outbreak position etc. are relevant.For referencial use with powder: every 5-10 square centimeter is 1 subsides, and cold water, vegetable oil or Mel are transferred and applied, and once-a-day, the same day, random time was applied ointment or plaster, and 10 days is a course of treatment.
(4) efficacy assessment standard
Cure: the arthralgia complete obiteration; Take a turn for the better: the area that swells and ache dwindles, and pain disappears basically; Invalid: swelling and ache obviously increases or maintains the original state.
(5) therapeutic outcome
Gout, articular sprain, contusion, infection of joint inflammation etc., all can cure a course of treatment.Observe in 3660 examples, cure 3655 examples, 5 examples that take a turn for the better, cure rate is 99%, total effective rate is 100%.
Claims (6)
1. external used medicine of treating arthralgia and gout is characterized in that: processed by following natural Chinese medicine raw material in this external used medicine of weight proportion:
Thallus Laminariae (Thallus Eckloniae) 12-18, Pseudobulbus Bletillae (Rhizoma Bletillae) 9-15, Radix Trichosanthis 9-15, Sargassum 12-18, Herba Violae 15-30; Radix Sophorae Flavescentis 15-30, Cortex Phellodendri 21-30, Radix Scutellariae 9-15, Spica Prunellae 30-45, Semen Litchi 12-18; Fructus Rosae Laevigatae 21-30, Fructus Gardeniae 12-18, Herba Andrographis 30-45, Rhizoma Paridis 15-30, triangular 12-18; Radix Et Rhizoma Rhei 6-10, Rhizoma Curcumae 12-18, Caulis Akebiae 15-20, Rhizoma Curcumae Longae 12-18, Borneolum Syntheticum 6-9.
2. a kind of external used medicine of treating arthralgia and gout according to claim 1 is characterized in that this external used medicine processed by following Chinese medicine raw materials by weight proportion:
Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23, Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15, Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15, Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8.
3. a kind of external used medicine of treating arthralgia and gout according to claim 1 is characterized in that: the dosage form of this external used medicine is powder, unguentum or spray.
4. a kind of external used medicine of treating arthralgia and gout according to claim 3, it is characterized in that: this external used medicine is a powder.
5. the method for preparing of an external used medicine as claimed in claim 1, the step that it is characterized in that preparing this external used medicine is following:
(1) take by weighing each raw material by following formula ratio:
Thallus Laminariae (Thallus Eckloniae) 12-18, Pseudobulbus Bletillae (Rhizoma Bletillae) 9-15, Radix Trichosanthis 9-15, Sargassum 12-18, Herba Violae 15-30; Radix Sophorae Flavescentis 15-30, Cortex Phellodendri 21-30, Radix Scutellariae 9-15, Spica Prunellae 30-45, Semen Litchi 12-18; Fructus Rosae Laevigatae 21-30, Fructus Gardeniae 12-18, Herba Andrographis 30-45, Rhizoma Paridis 15-30, triangular 12-18; Radix Et Rhizoma Rhei 6-10, Rhizoma Curcumae 12-18, Caulis Akebiae 15-20, Rhizoma Curcumae Longae 12-18, Borneolum Syntheticum 6-9;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei are total to Six-element decocte with water 2 times, each one to two hour, relative density 1.30 to 1.32 when collecting decoction, filtration, filtrating were concentrated into 60 ℃, got I;
(5) with above-mentioned fine powder and I mixing, drying becomes powder, unguentum or spray with pharmaceutically acceptable preparing carriers.
6. the method for preparing of an external used medicine as claimed in claim 5, the step that it is characterized in that preparing this external used medicine is following:
(1) takes by weighing each raw material by following weight ratio: Thallus Laminariae (Thallus Eckloniae) 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Radix Trichosanthis 12, Sargassum 15, Herba Violae 23; Radix Sophorae Flavescentis 23, Cortex Phellodendri 26, Radix Scutellariae 12, Spica Prunellae 38, Semen Litchi 15; Fructus Rosae Laevigatae 21, Fructus Gardeniae 15, Herba Andrographis 38, Rhizoma Paridis 23, triangular 15; Radix Et Rhizoma Rhei 8, Rhizoma Curcumae 15, Caulis Akebiae 18, Rhizoma Curcumae Longae 15, Borneolum Syntheticum 8;
(2) Thallus Laminariae (Thallus Eckloniae), Sargassum, Herba Violae, Radix Scutellariae, Spica Prunellae, Semen Litchi, Fructus Rosae Laevigatae, Herba Andrographis, Rhizoma Paridis, triangular, Rhizoma Curcumae, Caulis Akebiae, Rhizoma Curcumae Longae are pulverized, cross that 120 mesh sieves get fine powder and coarse powder is for use;
(3) borneol and grinding is become fine powder, cross 120 mesh sieves, for use;
(4) above-mentioned coarse powder and Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Trichosanthis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Gardeniae, Radix Et Rhizoma Rhei are total to Six-element decocte with water 2 times, each one to two hour, collecting decoction, filtration, relative density 1.30 to 1.32 when filtrating is concentrated into 60 ℃ gets I;
(5) with above-mentioned fine powder and I mixing, drying was pulverized 120 mesh sieves and was prepared into powder.
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CN105250817A (en) * | 2015-11-11 | 2016-01-20 | 广东明荃生物科技有限公司 | Herbaceous plant containing tea for treating gout and joint pain and reducing uric acid |
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