CN111632112A - Wind-calming and collateral-dredging preparation and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation for calming endogenous wind and dredging collaterals and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials, by weight, 240 parts of 200-containing gastrodia elata, 290 parts of 280-containing uncaria, 260 parts of 220-containing arisaema cum bile, 400 parts of 350-containing white paeony root, 250 parts of 210-containing codonopsis pilosula, 500 parts of 460-containing oyster, 250 parts of 230-containing asparagus, 380 parts of 350-containing caulis spatholobi, 270 parts of 230-containing salvia miltiorrhiza, 160 parts of 140-containing scorpio, 250 parts of 230-containing bombyx batryticatus and 280 parts of 230-containing achyranthes bidentata. Through tests, the effective rate of the medicine for treating the apoplexy patients reaches 96.29 percent, and the medicine meets the requirement of safety test.

Description

Wind-calming and collateral-dredging preparation and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation for calming endogenous wind and dredging collaterals and a preparation method thereof.

Background

Stroke is a clinically common neurological disorder. It is mainly manifested as hemiplegia, slurred speech and facial and lingual deflection. The Chinese medicine of this disease is recorded specially in the "Nei Jing" (internal classic). The pathogenesis of apoplexy is complicated, and it is common to have obstruction of collaterals by wind-phlegm and obstruction of phlegm-blood stasis. Wind-phlegm obstructing the collaterals, phlegm-stasis obstructing each other and brain collaterals obstruction, so hemiplegia, facial distortion and slurred speech are seen.

Although there are various preparations of Chinese and Western medicines in clinic, the curative effect of apoplexy is not ideal from the clinical practical treatment result.

Disclosure of Invention

The invention provides a preparation for calming endogenous wind and dredging collaterals and a preparation method thereof, and solves the technical problem that the preparation in the prior art has poor curative effect on the endogenous wind.

In order to achieve the purpose, one aspect of the embodiment of the invention provides a preparation for calming endogenous wind and dredging collaterals, which comprises the following raw materials, by weight, 240 parts of gastrodia elata 200-.

Further, the preparation for calming endogenous wind and dredging collaterals comprises the following raw materials, by weight, 200 parts of gastrodia elata, 280 parts of uncaria, 220 parts of arisaema cum bile, 350 parts of white paeony root, 210 parts of codonopsis pilosula, 460 parts of oyster, 230 parts of radix asparagi, 350 parts of suberect spatholobus stem, 230 parts of salvia miltiorrhiza, 140 parts of scorpion, 230 parts of stiff silkworm and 230 parts of twotooth achyranthes root.

Furthermore, the preparation for calming endogenous wind and dredging collaterals comprises the following raw materials, by weight, 240 parts of gastrodia elata, 288 parts of uncaria, 240 parts of arisaema cum bile, 360 parts of white paeony root, 240 parts of codonopsis pilosula, 480 parts of oyster, 240 parts of asparagus, 360 parts of suberect spatholobus stem, 240 parts of salvia miltiorrhiza, 144 parts of scorpion, 240 parts of stiff silkworm and 240 parts of achyranthes root.

Furthermore, the preparation for calming endogenous wind and dredging collaterals comprises, by weight, 240 parts of gastrodia elata, 290 parts of uncaria, 260 parts of arisaema cum bile, 400 parts of white paeony root, 250 parts of codonopsis pilosula, 500 parts of oyster, 250 parts of asparagus, 380 parts of suberect spatholobus stem, 270 parts of salvia miltiorrhiza, 160 parts of scorpion, 250 parts of stiff silkworm and 280 parts of twotooth achyranthes root.

Further, the preparation for calming endogenous wind and dredging collaterals is one of tablets, capsules, granules or pills.

A method for preparing pill for calming endogenous wind and dredging collaterals comprises (1) mixing rhizoma Gastrodiae, ramulus Uncariae cum uncis, rhizoma arisaematis cum bile, radix Paeoniae alba, radix Codonopsis, Concha Ostreae, radix asparagi, caulis Spatholobi, Saviae Miltiorrhizae radix, Scorpio, Bombyx Batryticatus and Achyranthis radix, air-blast drying at 60 deg.C, pulverizing into fine powder, and sieving; (2) adding refined honey 80-100 parts per 100 parts of powder, making into honeyed pill, and packaging to obtain the final product.

Compared with the prior art, the invention has the beneficial effects that: the gastrodia elata, the uncaria and the scorpion are used together for calming liver wind and relaxing channels and collaterals, the gastrodia elata, the uncaria and the scorpion are combined as monarch drugs, the raw white paeony root, the suberect spatholobus stem and the radix asparagi are used for calming liver and nourishing blood and yin, the arisaema cum bile and the stiff silkworm are used for reducing phlegm, calming endogenous wind and dredging collaterals; the salvia miltiorrhiza removes stasis and relieves pain, and activates blood and stimulates the menstrual flow; codonopsis pilosula tonifies middle-jiao energy, qi circulation is blood circulation; the seven medicines are used as ministerial medicines together, and cooperate with monarch medicines to play the roles of eliminating phlegm, calming endogenous wind, removing blood stasis and dredging collaterals; the oyster has the effects of yin-nourishing, yang-tonifying, hardness-softening and stagnation-dissipating, the achyranthes root is used for removing blood stasis and stimulating the menstrual flow, and blood is led to descend, the two medicines are used as adjuvant and guiding medicines together, the effects of eliminating phlegm and calming wind, removing blood stasis and dredging collaterals are achieved, and the oyster has a better treatment effect on patients with stroke which are distinguished as wind-phlegm stasis type. Through tests, the effective rate of the medicine for treating the apoplexy patients reaches 96.29 percent, and the medicine meets the requirement of safety test.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The terms "first" and "second," and the like, in the description and in the claims of embodiments of the present invention are used for distinguishing between different objects and not for describing a particular order of the objects. For example, the first parameter set and the second parameter set, etc. are used to distinguish different parameter sets, rather than to describe a particular order of parameter sets.

In the description of the embodiments of the present invention, the meaning of "a plurality" means two or more unless otherwise specified. For example, a plurality of elements refers to two elements or more.

The term "and/or" herein is an association relationship describing an associated object, and means that there may be three relationships, for example, a display panel and/or a backlight, which may mean: there are three cases of a display panel alone, a display panel and a backlight at the same time, and a backlight alone. The symbol "/" herein denotes a relationship in which the associated object is or, for example, input/output denotes input or output.

In the embodiments of the present invention, words such as "exemplary" or "for example" are used to mean serving as examples, illustrations or descriptions. Any embodiment or design described as "exemplary" or "e.g.," an embodiment of the present invention is not necessarily to be construed as preferred or advantageous over other embodiments or designs. Rather, use of the word "exemplary" or "such as" is intended to present concepts related in a concrete fashion.

Apoplexy is usually caused by imbalance of yin and yang, adverse qi and blood attacking the brain, sudden coma, unconsciousness, hemiplegia, and tongue and mouth

Inclining; or coma, hemiplegia, mouth and tongue

Oblique, difficult speaking and hemianesthesia are the main symptoms. According to traditional Chinese medicine, the stroke is the syndrome of origin deficiency and secondary excess, and the origin is the predominance of yin and yang, and the qi movement is disordered; the signs are flaring of wind and fire, phlegm stagnation and blood stasis. Therefore, the treatment should be performed by calming liver wind, clearing heat and eliminating phlegm, eliminating phlegm and clearing hollow viscera, promoting blood circulation and removing obstruction in channels. The wind-calming collateral-dredging preparation provided by the embodiment of the invention is a traditional Chinese medicine compound preparation which is developed according to the traditional Chinese medicine theory and on the basis of long-term clinical application in the institute, and by referring to modern pharmacological research results.

The pill is prepared from rhizoma Gastrodiae, ramulus Uncariae cum uncis, rhizoma arisaematis cum bile, radix Paeoniae alba, radix Codonopsis, Concha Ostreae, radix asparagi, caulis Spatholobi, Saviae Miltiorrhizae radix, Scorpio, Bombyx Batryticatus, and Achyranthis radix. It is mainly used for treating hemiplegia due to wind phlegm stagnation, manifested by facial distortion, language slurred or aphasia, numbness of limbs, dizziness, excessive and sticky phlegm, dark tongue, thin white or white greasy tongue fur, and wiry and slippery pulse.

In the recipe, Tian Ma is sweet, pungent and mild. It enters liver, spleen, kidney, gallbladder, heart and bladder meridians. The function of calming endogenous wind and relieving spasm; calming liver yang; dispel wind and dredge collaterals. The traditional Chinese medicine composition is mainly used for treating headache, dizziness, hemiplegia, limb numbness and rheumatic arthralgia clinically. The 'materia medica new edition' includes: gastrodia elata has the effects of relieving dizziness, treating wind and dampness, treating spasm and paralysis of tendons and bones, promoting blood circulation and inducing resuscitation. In the treatise on herb property, Tian Ma can be indicated for stubborn cold-air arthralgia, paralysis and paralysis, absentmindedness, and convulsion and loss of will. Uncaria rhynchophylla is sweet and bitter in taste and slightly cold in nature. Has the functions of clearing heat, calming liver, calming endogenous wind and relieving spasm. Compendium contains: dizziness due to rotation of the head of the adult, calming liver wind, removing heart heat, abdominal pain during fishing in children, and macula.

Uncaria is recorded in the book of materia medica: it is indicated for paralysis due to apoplexy, facial distortion, pain of palms and soles, spasm of limbs and joints. It is also indicated for gout, paralysis and spasm of tendons and muscles in the last year. In the formula, the gastrodia elata and the uncaria are mutually reinforced to play the roles of calming liver wind and suppressing yang, and are set aiming at the key of pathogenesis and are monarch drugs.

Bai Shao is bitter and sour in flavor and slightly cold in nature. It enters liver and spleen meridians. Has the functions of calming the liver, relieving pain, nourishing blood, regulating menstruation, astringing yin and arresting sweating. It is often used for treating irregular menstruation; the recipe can enhance the effect of the monarch drug in calming the liver, and can be used for treating abdominal pain during menstruation, metrorrhagia and metrostaxis, spontaneous perspiration and night sweat, hypochondriac pain, abdominal pain, limb contracture pain, headache and vertigo. Codonopsis pilosula is sweet in flavor and neutral in nature. It enters spleen and lung meridians. Is mainly used for treating spleen and stomach weakness, anorexia, loose stool, extremity debilitation, lung deficiency, cough and asthma, short breath, spontaneous perspiration, and deficiency of both qi and blood. Tian Dong is sweet, bitter and cold in nature. It enters liver, lung, kidney and lung meridians. Has the effects of soothing the nerves, nourishing the heart, moistening the lung, tonifying, nourishing the kidney and relaxing the bowels. For cough with lung-qi, rapid respiration, heat-clearing, kidney-qi dredging, lung atrophy treating, carbuncle generating, pus discharging, damp scabies treating, thirst quenching, heat-clearing and apoplexy curing, it is suitable for long-term use in the treatmentof the herb property treatmentof the drug in the treatmentof the drug property treatmentof the drug in the recipe.

Spatholobus stem, bitter in taste, slightly sweet and warm in nature. It enters heart and spleen meridians. The main treatment is as follows: numbness of hands and feet; paralysis of limbs; rheumatic arthralgia; irregular menstruation of women; dysmenorrhea; amenorrhea. Compendium of materia Medica supplement: promoting blood circulation, warming waist and knees, and treating paralysis. Decoction piece New references: to remove blood stasis, promote blood generation and induce diuresis. For summer-heat syndrome, wind-blood arthralgia. Dan Shen is bitter in taste and slightly cold in nature. It enters heart, pericardium and liver meridians. Has the effects of promoting blood circulation and removing blood stasis; regulating menstruation and relieving pain; nourishing blood and tranquilization; cool blood and cure abscess. The seven ingredients are used as ministerial drugs in the formula or assist monarch drugs to strengthen the effect of calming liver wind, or assist the effect of promoting blood circulation and removing obstruction in channels, or assist the effect of removing blood stasis and removing obstruction in channels.

Mu Li is salty in taste and slightly cold in nature. The functions of the Chinese herbal medicine are heavy in weight, tranquilize mind, subdue yang, tonify yin, soften hardness, dissipate stagnation, astringe and arrest discharge. Arisaema cum bile, bitter in taste and cool in nature. Has the functions of clearing heat, resolving phlegm, calming endogenous wind and arresting convulsion. The two medicines enhance the effect of the monarch and ministerial medicines on calming endogenous wind and reducing phlegm in the formula.

Quan Xie is pungent in flavor and neutral in nature. It enters liver meridian. Has the effects of dispelling pathogenic wind and relieving spasm; dredging collaterals and relieving pain; it is said from KAI BAO BEN CAO (KAI BAO materia Medica) that it can cure the symptoms of hemiplegia due to apoplexy, facial distortion, unsmooth speech, and dragging hands and feet. The scorpion recorded in materia medica Zhenzhen records that the scorpion specially enters the liver to dispel wind, and is not used for treating infantile convulsion, hemiplegia, facial distortion, slurred speech, tetany, malaria, cold and hot, deafness and leukorrhagia due to exogenous wind and endogenous cold.

Bombyx Batryticatus is pungent, salty and neutral in flavor. It enters liver, lung and stomach meridians. Has the functions of dispelling wind, arresting convulsion, reducing phlegm and resolving masses. Can be used for treating convulsion, and sore throat. In the recipe, quan Xie and Jiang Can are mainly aimed at the symptoms of wind hemiplegia, facial distortion, unsmooth speech and headache. The four medicines are used as adjuvant medicines in the prescription.

Niu xi, bitter and sour in taste, neutral in nature, enters liver and kidney meridians. Has the functions of nourishing liver and kidney, strengthening bones and muscles, promoting blood circulation and stimulating the menstrual flow, and guiding various medicines downwards. Therefore, they are used as guiding drugs in the recipe. The prescription is good at the pathogenesis, delicate in compatibility and great in medicinal power. Rhizoma Gastrodiae, ramulus Uncariae cum uncis, radix Paeoniae alba, rhizoma arisaematis cum bile, Concha Ostreae, Scorpio, and Bombyx Batryticatus can calm liver, stop endogenous wind and subdue yang. Radix Paeoniae alba is combined with radix Codonopsis, radix asparagi, caulis Spatholobi, and Saviae Miltiorrhizae radix etc. to nourish blood, promote blood circulation, remove blood stasis, and dredge collaterals. Concha Ostreae, Arisaema cum bile, Scorpio, and Bombyx Batryticatus are added to dispel wind and relieve spasm, resolve phlegm and dissipate nodulation. The whole formula has the effects of eliminating phlegm and calming wind, and removing blood stasis and dredging collaterals. It can be used for treating hemiplegia due to wind phlegm stagnation, manifested by facial distortion, language handicap, numbness of limbs, dizziness, excessive phlegm, pale tongue, thin white tongue fur, and wiry and smooth pulse.

One aspect of the embodiment of the invention provides a wind-calming and collateral-dredging preparation, which comprises the following raw materials, by weight, 240g of gastrodia elata 200-.

The gastrodia elata, the uncaria and the scorpion are used together for calming liver wind and relaxing channels and collaterals, the gastrodia elata, the uncaria and the scorpion are combined as monarch drugs, the raw white paeony root, the suberect spatholobus stem and the radix asparagi are used for calming liver and nourishing blood and yin, the arisaema cum bile and the stiff silkworm are used for reducing phlegm, calming endogenous wind and dredging collaterals; the salvia miltiorrhiza removes stasis and relieves pain, and activates blood and stimulates the menstrual flow; codonopsis pilosula tonifies middle-jiao energy, qi circulation is blood circulation; the seven medicines are used as ministerial medicines together, and cooperate with monarch medicines to play the roles of eliminating phlegm, calming endogenous wind, removing blood stasis and dredging collaterals; the oyster has the effects of yin-nourishing, yang-tonifying, hardness-softening and stagnation-dissipating, the achyranthes root is used for removing blood stasis and stimulating the menstrual flow, and blood is led to descend, the two medicines are used as adjuvant and guiding medicines together, the effects of eliminating phlegm and calming wind, removing blood stasis and dredging collaterals are achieved, and the oyster has a better treatment effect on patients with stroke which are distinguished as wind-phlegm stasis type. Through tests, the effective rate of the medicine for treating the apoplexy patients reaches 96.29 percent, and the medicine meets the requirement of safety test.

Clinical material tested, 67 men and 41 women; the age is 40-69 years; of the three cases, 48 cases of cerebral hemorrhage, 60 cases of cerebral infarction, 89 cases of limb dysfunction, 69 cases of language dysfunction, 36 cases of limb numbness and 49 cases of swallowing dysfunction. Of 106 cases taking the Naodesheng, 69 men and 37 women; age between 41-69 years; among them, 46 cases of cerebral hemorrhage, 60 cases of cerebral infarction, 88 cases of patients with limb dysfunction, 65 cases of patients with language dysfunction, 33 cases of patients with limb numbness, and 45 cases of patients with dysphagia. According to the "diagnosis criteria of apoplexy syndromes", all cases refer to the syndrome of wind-phlegm stasis, wherein 5 cases of mild syndrome, 68 cases of moderate syndrome and 35 cases of severe syndrome are taken as the pill for calming wind and dredging collaterals in this embodiment. The disease course of all cases is within 6 months after taking 6 cases with mild syndrome, 68 cases with moderate syndrome and 32 cases with severe syndrome.

Diagnosis standard of stroke: according to the Chinese medicine administration's brain disease emergency scientific research cooperative group drafted ' Zhongfeng disease diagnosis and treatment effect evaluation Standard ' (trial).

The main symptoms are: hemiplegia, coma, slurred speech or loss of speech, abnormal sensation in the body, and facial distortion.

The secondary symptoms are as follows: headache, vertigo, mydriasis, choking of drinking water, impaired vision and ataxia.

Acute onset usually has a predisposing cause before onset, and a premonitory symptom is usually observed.

The onset age is usually 40 years or older.

The diagnosis can be confirmed by combining the onset, the cause, the premonitory symptoms and the age, wherein the number of the main symptoms is more than 2, or 1 main symptom and 2 secondary symptoms; without the above conditions, the diagnosis can be confirmed by combining the results of the imaging examination.

2. Syndrome diagnostic criteria

The diagnosis standard of apoplexy syndrome is formulated according to the national institute of traditional Chinese medicine and drug cooperative for brain disease and emergency research.

The test method comprises the following steps:

the test group takes the oral preparation for calming endogenous wind and dredging collaterals, 1 pill is taken once, 2 times a day, and 4 weeks are a course of treatment.

The control group comprises Naodesheng tablets, pseudo-ginseng, safflower, ligusticum wallichii, hawthorn, kudzu root and the like, and the Naodesheng tablets are orally taken 3 tablets each time and 3 times a day with warm boiled water. Specification: each tablet weighs 0.4 g; appearance: the product is in the form of tablet, and is in yellow brown color after coating is removed; slightly bitter in taste.

The curative effect standard is as follows:

the basic cure is as follows: the functional impairment score is reduced by 91-100%, and the disease disability degree is grade 0.

The remarkable progress is that: the functional impairment score is reduced by 46-90%, and the disease disability degree is grade 1-3.

The improvement is as follows: the functional impairment score is reduced by 18-45%.

No change: the functional impairment score is reduced or increased by within 18%.

Deterioration: the functional impairment score is increased by more than 18%.

And (3) safety evaluation:

first-stage: safe and has no adverse reaction; the security index checks for no anomalies.

And (2) second stage: is safe, has mild adverse reaction, and can continue to treat without any treatment; the security index checks for no anomalies.

Third-stage: has safety problem, moderate adverse reaction or slight abnormality in safety index inspection, and can continue to be treated after treatment.

And (4) fourth stage: discontinuation of the test due to severe adverse reactions; or an abnormality is manifested upon checking the safety index.

Neurological impairment scores change by difference pre-treatment-post-treatment scores.

Neurological deficit score-score before treatment-score after treatment)/score before treatment × 100%.

This study will employ a benefit analysis. All statistical tests adopt a two-sided test, and if no special description is given, P is less than 0.05 to be used as a standard for judging that the difference has statistical significance.

And (3) test results:

after 12 weeks of treatment, the functions of the neurological deficits of the two groups are improved and compared, the U is 1.41, the P is more than 0.05, and the difference is not significant. However, after the two groups of data, the treatment group is treated for 12 weeks, and the mild syndrome types of the 5 cases before treatment are basically all normal; the mild pattern in the 6 cases before the treatment in the control group was all normal in 5 cases, and 1 case was unchanged. The test group had 43 of the 68 cases of moderate syndrome before treatment changed to mild syndrome (63.24%), and 25 cases were all normal (36.76%); in the 68 cases before the treatment of the control group, 40 of the moderate syndrome types are changed into mild syndrome types (accounting for 58.82 percent), 22 cases are basically all normal (accounting for 32.35 percent), and 6 cases are not obviously changed. The test group had 18 cases of severe syndrome type to moderate syndrome type (accounting for 51.43%), 8 cases to mild syndrome type (accounting for 22.86%) and 9 cases with no obvious change (accounting for 25.71%) before treatment; in the control group, 15 of the 32 cases before treatment were changed from the severe syndrome type to the moderate syndrome type (46.88%), 7 cases were changed to the mild syndrome type (21.88%), and 10 cases were not obvious (31.25%). The test group is proved to have better effect on improving the function of the nerve defect.

In the treatment group, no obvious adverse reaction is found, and no influence on liver, kidney function and hematopoietic system is found, which indicates that the product is safe to use.

Apoplexy is a disease mainly caused by sudden syncope, unconsciousness, hemiplegia, facial distortion and language disorder, and mild patients may have no syncope but only hemiplegia and facial distortion

Oblique, etc. Su Wen & Sheng Qi Tong Tian Lun (plain questions & Qi Tong Tian Lun) Yun: the occurrence of this disease is considered to be related to the restlessness and rage, because the yang qi is anger and qi is exhausted, and the blood is higher than the blood and causes faint. Modern physicians summarize the previous experience, and further recognize that the disease is mainly caused by transformation of liver yang into wind, adverse flow of qi and blood, and direct attack on the brain. The acute stage of the disease is characterized by sudden expansion of liver yang, internal wind rotation, phlegm inclusion and fire inclusion, transverse channel and collateral channeling and mind shielding, the treatment is mainly to dispel phlegm and stop the wind, remove blood stasis and dredge collaterals, the effects of calming the liver and relieving the wind, dredging the channels and dredging the collaterals are taken by the gastrodia elata, the uncaria and the scorpion together, the three are combined as monarch drugs, the white paeony root, the suberect spatholobus stem and the asparagus fern are used for calming the liver and nourishing yin, the arisaema cum bile and the stiff silkworm are used; the salvia miltiorrhiza removes stasis and relieves pain, and activates blood and stimulates the menstrual flow; codonopsis pilosula tonifies middle-jiao energy, qi circulation is blood circulation; the seven medicines are used as ministerial medicines together, and cooperate with monarch medicines to play the roles of eliminating phlegm, calming endogenous wind, removing blood stasis and dredging collaterals; oyster shell, achyranthes and cyathula root, radix achyranthis bidentatae, oyster shell, radix achyranthis bidentatae, achyranthes and cyathula root, radix achyranthis bidentatae, and achyranthes and cyathula root, radix achyranthis bidentatae, the above two. The medicines are used together to achieve the effects of eliminating phlegm and calming endogenous wind, and removing blood stasis and dredging collaterals, and are particularly effective for patients suffering from wind-phlegm stasis type apoplexy.

Patient xuwenhe, male, 65 years old, farmer, shaxi. The patient is admitted to the hospital 10, 8 days in 2016 because of dizziness, headache, numbness of the left limbs and twitching of the eyes and mouth for 10 hours. The patient feels discomfort due to head swelling and numbness of the two upper limbs after morning exercise 10 hours before admission, the dizziness gradually worsens and the headache occurs 8 hours before admission, the mouth and the canthus on the left side continuously twitch, the symptom is continuously not reduced, nausea and vomiting do not occur, the patient does not see object rotation, the patient feels weakness in the left hand and movement difficulty and the lower limbs on the left side on the basis of the symptoms 3 hours before admission, the dizziness is reduced before the patient takes 'Beijing decompression No. 0', and the admission symptoms are shown: dizziness and headache are aggravated by forehead and back occipital, convulsion on the left face, dribbling, numbness and weakness of the left limbs, clear speech, poor sleep and smooth defecation. The past history of hypertension is 8 years, and the history of cerebral hemorrhage and cerebral infarction is 1 year. Physical examination: clear spirit, poor spirit, clear speech and left hand. The left nasolabial sulcus becomes shallow, the tongue is stretched to the right, the muscle tension of four limbs is not high, the near-end muscle strength of the left upper limb is 4-grade, the far-end muscle strength is 4-grade, and the muscle strength of the left lower limb is 4+ grade. Left biceps brachii reflex, radial periosteal reflex, knee tendon reflex, and achilles tendon reflex (+++). Double sided Hoffman sign (-), double sided Babinski sign (+). NIHSS scoring: and 36 minutes. A pale-red tongue with white and greasy coating and a wiry and slippery pulse, which is sunken in the ulnar part and weak. Head MRI show: ischemic changes in the right basal ganglia region. Admission diagnosis: traditional Chinese medicine diagnosis: apoplexy-involving the meridians (wind-phlegm obstructing the collaterals); and (3) Western diagnosis: cerebral infarction. The treatment scheme comprises the following steps: orally administering pill for calming endogenous wind and dredging collaterals, acupuncture Jianjiayu, Jiquan, Quchi, Shousanli, Hegu, Waiguan, Huanjiao, Yanglingquan, Taichong, Taixi, Fenglong, Zusanli, etc. After 4 weeks of treatment, the patient occasionally had dizziness and discomfort, convulsion occurred in the left corner of the mouth, and the left limb was more powerful but with obvious heavy sensation. Physical examination: blood pressure 150/80mmHg, left nasolabial sulcus becomes shallow, left muscle tension is not high, left tendon reflex is weakened, distal muscle strength of left upper limb is grade 3, proximal end is grade 4, bilateral knee tendon reflex is active, left hypoalgesia is caused, and pathological reflex is not led out. NIHSS scoring: and 65 minutes. A pale-red tongue with thin and white coating and a thready and slippery pulse, and a deep ulnar part failing to act. Order the patient to take the medicine out of the hospital and follow the clinic for discomfort.

By observing 108 patients with apoplexy sequelae, no obvious adverse reaction is found, and no influence on liver, kidney function and hematopoietic system is found, which indicates that the product is safe to use. And is widely favored by patients for the curative effect of the preparation.

Example 1, the wind-calming and collateral-dredging preparation is prepared from 200g of gastrodia elata, 280g of uncaria, 220g of arisaema cum bile, 350g of radix paeoniae alba, 210g of codonopsis pilosula, 460g of oyster, 230g of radix asparagi, 350g of caulis spatholobi, 230g of salvia miltiorrhiza, 140g of scorpion, 230g of stiff silkworm and 230g of achyranthes bidentata.

The preparation for calming wind and dredging collaterals in the embodiment is a pill and comprises the following steps of (1) mixing 200g of gastrodia elata, 280g of uncaria, 220g of arisaema cum bile, 350g of white paeony root, 210g of codonopsis pilosula, 460g of oyster, 230g of asparagus, 350g of suberect spatholobus stem, 230g of salvia miltiorrhiza, 140g of scorpion, 230g of stiff silkworm and 230g of twotooth achyranthes root, drying by blowing at 60 ℃, crushing into fine powder and sieving for later use; (2) adding refined honey 80g per 100g powder, making into honeyed pill, packaging inside, packaging outside, and packaging to obtain the final product.

Example 2, the wind-calming and collateral-dredging preparation is prepared from 240g of gastrodia elata, 288g of uncaria, 240g of arisaema cum bile, 360g of white peony root, 240g of codonopsis pilosula, 480g of oyster, 240g of asparagus, 360g of suberect spatholobus stem, 240g of salvia miltiorrhiza, 144g of scorpion, 240g of stiff silkworm and 240g of achyranthes bidentata.

The preparation for calming wind and dredging collaterals in the embodiment is a pill and comprises the following steps of (1) mixing 240g of gastrodia elata, 288g of uncaria, 240g of arisaema cum bile, 360g of white paeony root, 240g of codonopsis pilosula, 480g of oyster, 240g of asparagus, 360g of suberect spatholobus stem, 240g of salvia miltiorrhiza, 144g of scorpion, 240g of stiff silkworm and 240g of twotooth achyranthes root, drying by blowing at 60 ℃, crushing into fine powder and sieving for later use; (2) adding 90g of refined honey into every 100g of powder, and making into honeyed pills, internal packaging, external packaging, boxing and packaging to obtain the finished product.

Example 3, the wind-calming and collateral-dredging preparation is prepared from 240g of gastrodia elata, 290g of uncaria, 260g of arisaema cum bile, 400g of radix paeoniae alba, 250g of codonopsis pilosula, 500g of oyster, 250g of radix asparagi, 380g of caulis spatholobi, 270g of salvia miltiorrhiza, 160g of scorpion, 250g of stiff silkworm and 280g of achyranthes bidentata.

The preparation for calming wind and dredging collaterals in the embodiment is a pill and comprises the following steps of (1) mixing 240g of gastrodia elata, 290g of uncaria, 260g of arisaema cum bile, 400g of white paeony root, 250g of codonopsis pilosula, 500g of oyster, 250g of asparagus, 380g of suberect spatholobus stem, 270g of salvia miltiorrhiza, 160g of scorpion, 250g of stiff silkworm and 280g of twotooth achyranthes root, drying by blowing at 60 ℃, crushing into fine powder and sieving for later use; (2) adding 90g of refined honey into every 100g of powder, and making into honeyed pills, internal packaging, external packaging, boxing and packaging to obtain the finished product.

The preparation for calming endogenous wind and dredging collaterals is one of tablets, capsules, granules or pills.

The above embodiments are only used for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof; such modifications and substitutions do not depart from the spirit and scope of the present invention as set forth in the appended claims.

Claims (6)

1. A preparation for calming endogenous wind and dredging collaterals is characterized in that: the traditional Chinese medicine composition comprises the following raw materials, by weight, 240 parts of 200-containing gastrodia elata, 290 parts of 280-containing uncaria, 260 parts of 220-containing arisaema cum bile, 400 parts of 350-containing white paeony root, 250 parts of 210-containing codonopsis pilosula, 500 parts of 460-containing oyster, 250 parts of 230-containing asparagus, 380 parts of 350-containing caulis spatholobi, 270 parts of 230-containing salvia miltiorrhiza, 160 parts of 140-containing scorpio, 250 parts of 230-containing bombyx batryticatus and 280 parts of 230-containing achyranthes bidentata.

2. The wind-calming collateral-dredging preparation according to claim 1, wherein: the traditional Chinese medicine composition comprises, by weight, 200 parts of gastrodia elata, 280 parts of uncaria, 220 parts of arisaema cum bile, 350 parts of white paeony root, 210 parts of codonopsis pilosula, 460 parts of oyster, 230 parts of asparagus, 350 parts of suberect spatholobus stem, 230 parts of salvia miltiorrhiza, 140 parts of scorpion, 230 parts of stiff silkworm and 230 parts of achyranthes bidentata.

3. The wind-calming collateral-dredging preparation according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 240 parts of gastrodia elata, 288 parts of uncaria, 240 parts of arisaema cum bile, 360 parts of white paeony root, 240 parts of codonopsis pilosula, 480 parts of oyster, 240 parts of asparagus, 360 parts of caulis spatholobi, 240 parts of salvia miltiorrhiza, 144 parts of scorpion, 240 parts of stiff silkworm and 240 parts of achyranthes bidentata.

4. The wind-calming collateral-dredging preparation according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 240 parts of gastrodia elata, 290 parts of uncaria, 260 parts of arisaema cum bile, 400 parts of white paeony root, 250 parts of codonopsis pilosula, 500 parts of oyster, 250 parts of asparagus, 380 parts of suberect spatholobus stem, 270 parts of salvia miltiorrhiza, 160 parts of scorpion, 250 parts of stiff silkworm and 280 parts of achyranthes root.

5. The wind-calming collateral-dredging preparation according to any one of claims 1 to 4, wherein: the preparation for calming endogenous wind and dredging collaterals is one of tablets, capsules, granules or pills.

6. A preparation method of pills for calming endogenous wind and dredging collaterals is characterized by comprising the following steps: comprises the following steps of (1) mixing gastrodia elata, uncaria, arisaema cum bile, white paeony root, codonopsis pilosula, oyster, asparagus cochinchinensis, suberect spatholobus stem, salvia miltiorrhiza, scorpion, stiff silkworm and twotooth achyranthes root, drying by blowing air at 60 ℃, crushing into fine powder and sieving for later use; (2) adding refined honey 80-100 parts per 100 parts of powder, making into honeyed pill, and packaging to obtain the final product.