CN103768480B - A kind of Chinese medicine for the treatment of facial spasm and preparation method thereof - Google Patents
A kind of Chinese medicine for the treatment of facial spasm and preparation method thereof Download PDFInfo
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- CN103768480B CN103768480B CN201410046904.8A CN201410046904A CN103768480B CN 103768480 B CN103768480 B CN 103768480B CN 201410046904 A CN201410046904 A CN 201410046904A CN 103768480 B CN103768480 B CN 103768480B
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Abstract
The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of facial spasm and preparation method thereof.The Chinese medicine for the treatment of facial spasm of the present invention, is made up of the raw material of Chinese medicine medicine of following weight portion: Rhizoma alpiniae pumilae 25-35 part, Radix et rhizoma smilacinae japonicae 10-20 part, Radix Zanthoxyli Spinifolii 20-30 part, teacher ancestral fiber crops 4-8 part, Radix Saposhnikoviae 10-20 part, Herba Polygoni Runcinati 4-8 part, tetramerous jasminorange leaf 4-8 part, Scolopendra 2-4 part, Bombyx Batryticatus 6-12 part, Radix Clematidis 4-8 part, Radix Astragali 25-35 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Radix Angelicae Sinensis 10-20 part, Radix Glycyrrhizae 6-12 part.Chinese medicine of the present invention has dispelling wind and removing obstruction in the collateral, relaxing muscles and tendons and activating QI and blood in the collateral, nourishing YIN to relieve dryness, effect of cooling blood and relieving pain, clinical in facial spasm.This Chinese medicine has instant effect, good effect, the advantage had no adverse reaction, and avoids the misery performed the operation and be locally administered to patient and bring.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of facial spasm and preparation method thereof.
Background technology
Facial spasm refers to that the not autonomous paroxysmal tic sample of facial muscle shrinks, generally mostly be one-sided face, accidental bilateral, often originate in the not autonomous small twitch in eyelid bottom, gradually to face expansion, increase the weight of, along with the prolongation above-mentioned symptom of the course of disease can increase the weight of gradually when nervous fatigue, by time every day twitch for several times and develop into every day tens times, tic amplitude can cause violent tic by the little tic development in local.
Facial spasm Therapeutic Method is more, and the past often adopts antiepileptic, is aided with acupuncture and moxibustion therapy, and because toleration appears in long term combined use, and curative effect and toxic and side effects all exist dose dependent, so be subject to the restriction of drug dose, long-term efficacy is undesirable.Some cases makes stylomastoid foramen facial nerve block therapy, or percutaneous puncture radio frequency temperature control coagulation treatment heat, because its facial paralysis incidence rate reaches 100%, therefore fails to popularize.The microsurgical [neuro-of carrying out in recent years, because wound is large, technical requirement is high, risk is large, and is unfavorable for promoting at intermediate and small hospital.Local injection ethanol, creotoxin, pain is obvious, and patient treatment gets up more painful, has more on the face to inject the tiny needle eye shadow stayed and ring attractive in appearance.
Summary of the invention
Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine for the treatment of facial spasm and preparation method thereof.This Chinese medicine has instant effect, good effect, the advantage had no adverse reaction, and avoids the misery performed the operation and be locally administered to patient and bring.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine for facial spasm, be made up of the raw material of Chinese medicine medicine of following weight portion:
Rhizoma alpiniae pumilae 25-35 part, Radix et rhizoma smilacinae japonicae 10-20 part, Radix Zanthoxyli Spinifolii 20-30 part, teacher ancestral fiber crops 4-8 part, Radix Saposhnikoviae 10-20 part, Herba Polygoni Runcinati 4-8 part, tetramerous jasminorange leaf 4-8 part, Scolopendra 2-4 part, Bombyx Batryticatus 6-12 part, Radix Clematidis 4-8 part, Radix Astragali 25-35 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Radix Angelicae Sinensis 10-20 part, Radix Glycyrrhizae 6-12 part.
Preferably, the Chinese medicine of above-mentioned treatment facial spasm, be made up of the raw material of Chinese medicine medicine of following weight portion:
Rhizoma alpiniae pumilae 27-33 part, Radix et rhizoma smilacinae japonicae 13-17 part, Radix Zanthoxyli Spinifolii 23-27 part, teacher ancestral fiber crops 5-7 part, Radix Saposhnikoviae 13-17 part, Herba Polygoni Runcinati 5-7 part, tetramerous jasminorange leaf 5-7 part, Scolopendra 2.5-3.5 part, Bombyx Batryticatus 7-11 part, Radix Clematidis 5-7 part, Radix Astragali 27-33 part, Rhizoma Atractylodis Macrocephalae 27-33 part, Radix Angelicae Sinensis 13-17 part, Radix Glycyrrhizae 7-11 part.
Preferred, the Chinese medicine of above-mentioned treatment facial spasm, be made up of the raw material of Chinese medicine medicine of following weight portion:
Rhizoma alpiniae pumilae 30 parts, Radix et rhizoma smilacinae japonicae 15 parts, Radix Zanthoxyli Spinifolii 25 parts, teacher ancestral fiber crops 6 parts, Radix Saposhnikoviae 15 parts, Herba Polygoni Runcinati 6 parts, tetramerous jasminorange leaf 6 parts, Scolopendra 3 parts, Bombyx Batryticatus 9 parts, Radix Clematidis 6 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Radix Angelicae Sinensis 15 parts, 9 parts, Radix Glycyrrhizae.
The Chinese medicine of above-mentioned treatment facial spasm, this Chinese medicine is oral formulations, and preferably, the dosage form of this Chinese medicine is granule.
The preparation method of the Chinese medicine granules of above-mentioned treatment facial spasm, comprises following steps:
A () is by Rhizoma alpiniae pumilae, Radix et rhizoma smilacinae japonicae, Radix Zanthoxyli Spinifolii, Shi Zuma, Radix Saposhnikoviae, Herba Polygoni Runcinati, tetramerous jasminorange leaf, Radix Angelicae Sinensis 75% soak with ethanol of medical material volume 3 ~ 5 times amount reflux, extract, 2 times after 10 ~ 14 hours, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.05 ~ 0.07MPa for filtrate, and 60 DEG C are evaporated to the clear paste that relative density is 1.20 ~ 1.25;
B Scolopendra, Bombyx Batryticatus, Radix Clematidis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae 6 taste medical material are added the soak by water 2 times of above-mentioned medical material 6 ~ 8 times of weight by (), each decoction 0.5 ~ 1.5 hour, merge the fried liquid of twice, the half that former fried liquid is long-pending is evaporated at 60 DEG C, incline and to cool, cold preservation 12 hours, filter, filtrate 60 DEG C is evaporated to the clear paste that relative density is 1.25 ~ 1.28;
C () merges two parts clear paste, mixing, and drying under reduced pressure is pulverized, and crosses 100 mesh sieves, is prepared into extract powder, adds pharmaceutically acceptable adjuvant and make granule, to obtain final product.
Product carries out quality inspection, after the assay was approved package sterilization.Every bag heavy 10g, every gram, containing crude drug in whole 1.5 ~ 2.5g, takes three every day, each 1 bag.
Described pharmaceutically acceptable adjuvant is selected from: sucrose, starch, magnesium stearate, mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, tie up main plain E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, polysorbate60 ~ 80, department class ~ 80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, fine jade, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, β ~ cyclodextrin, phospholipid material, Kaolin, Pulvis Talci, calcium stearate etc.
Chinese medicine of the present invention has dispelling wind and removing obstruction in the collateral, relaxing muscles and tendons and activating QI and blood in the collateral, nourishing YIN to relieve dryness, effect of cooling blood and relieving pain, clinical in facial spasm.
In the Chinese medicine for the treatment of facial spasm of the present invention,
Rhizoma alpiniae pumilae another name Alpinia japonica (Thunb.) Miq., nine Jiang Lian, magnificent Rhizoma Alpiniae Officinarum are Zingiberaceae Alpinia plants Huashan Rhizoma Zingiberis Recens Alpinia chinensis Rosc. root stock.Pungent, temperature.Have expelling wind and removing dampness, vital energy regualting and blood circulation-promoting, removing toxic substances, effect of pain relieving, can relieving cough and asthma, dispersing cold for relieving pain, except rheumatism, separates sore.For wind and cold cough with asthma, peratodynia, Fengshi Guanjie pain, falls and damages blood stasis stagnation, menoxenia, innominate toxic swelling.
Radix et rhizoma smilacinae japonicae is rhizome and the root of Liliaceae Smilacina plant Radix et rhizoma smilacinae japonicae Smilacina japonica A.Gray.Sweetness and bitterness, temperature.Sweet have QI invigorating kidney tonifying, expelling wind and removing dampness, effect of promoting blood flow to regulate menstruation.The clinical treatment consumptive disease that is mainly used in is hindered, sexual impotence, inclined, aching all over the head, rheumatalgia, traumatic injury, acute mastitis, menoxenia.
Radix Zanthoxyli Spinifolii is root or the root bark of dicotyledon medicine rutaceae Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils Zanthoxylum dimorphophyllumHemsl.Var.spinifolium Rehd.Et Wils..Another name Radix Zanthoxyli Spinifolii, yellow pepper, thorn Acanthopanan trifoliatus (L.) Merr., red Sedum aizoon L..Pungent, temperature, enters liver, lung meridian.There is expelling wind and cold, relaxing muscles and tendons to promote blood circulation, analgesic effect.Clinically be mainly used in cough due to wind and cold, rheumatic numbness, traumatic injury, traumatic hemorrhage, constipation.
Teacher ancestral fiber crops are root bark and the peel of stem of thymelaeceae daphne plant Daphne Giraldii Nitsche Daphne giraldii Nitsche2.Daphne tanguticaMaxim.3.Daphne retusa Hemsl, call as Daphne Giraldii Nitsche, rescue greatly, Flos Wikstroemiae Nutantis, yellow dog skin.Arduous, temperature, slightly poisonous.Can expelling wind and removing dampness, pain relieving dissipating blood stasis.Clinically be mainly used in rheumatic arthralgia, numb limbs and tense tendons, headache, stomachache, traumatic injury.
Radix Saposhnikoviae is the root of the DivaricateSaposhnikoviaRoot of umbelliferae Saposhnikovia divaricata, another name copper rue, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds, there is expelling wind and removing dampness, effect of pain relieving dissipating blood stasis.Clinically be mainly used in rheumatic arthralgia, numb limbs and tense tendons, headache, stomachache, traumatic injury.
Herba Polygoni Runcinati is that Liliaceae Herba Polygoni Runcinati AspidistraluridaKer-Gawl. is used as medicine with root stock.Micro-hardship, flat.There is warming middle-JIAO, cold expelling, dispel the wind, the effect of invigorating blood circulation.Control coldness and pain in the epigastrium, rheumatism bones and muscles pain.
Tetramerous jasminorange leaf calls smelly paint, printing opacity grass, derives from Rutaceae Murraya plant tetramerous jasminorange leaf Murraya tetramera Huang, is used as medicine with Ye Hegen.Pungent, micro-hardship, tepor.There is expelling pathogenic wind from the body surface, promoting the circulation of QI to relieve pain, effect of promoting blood circulation to remove blood stasis.For cold, fever, bronchitis, asthma, rheumatic numbness, bones and muscles pain, traumatic injury swelling and pain due to blood stasis, skin pruritus, eczema, venom, malaria, stomachache, edema etc.
All the other Scolopendras, Bombyx Batryticatus, Radix Clematidis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Glycyrrhizae 7 taste medicine are the medical material that Chinese Pharmacopoeia 2010 editions is recorded.
Motherland's medical science is thought, facial spasm morbidity is many, and because of human righteousness's deficiency, venation is hollow, and space between skin and muscles is solid, and ailment said due to cold or exposure holds the warp that expectorant enters the bright few sun of septum reset sun under the arm, and cause muscle of facial expression natural fibre line of meat obstruction of meridians and collaterals, QI-blood circulation is unfavorable, and muscle muscle arteries and veins loses in moistening foster, therefore it is vertical to cause facial muscle contracture relaxation.The Radix Astragali, Rhizoma Atractylodis Macrocephalae invigorating the spleen and replenishing QI in Chinese medicine of the present invention, Radix Saposhnikoviae, Bombyx Batryticatus evacuate facial ailment said due to cold or exposure, Rhizoma alpiniae pumilae, Radix et rhizoma smilacinae japonicae, Radix Zanthoxyli Spinifolii, Shi Zuma, Herba Polygoni Runcinati, tetramerous jasminorange leaf, Radix Clematidis, Scolopendra wind-damp dispelling, the meridian dredging, expectorant saliva; According to the theory of " blood wind is from going out ", Chinese angelica blood supplementing is selected to invigorate blood circulation, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and play invigorating the spleen and replenishing QI altogether, expelling wind and removing dampness, phlegm reduction of blood circulation promoting, effect of removing obstruction in the collateral to relieve pain.
The invention has the advantages that:
(1) the invention provides a kind of Chinese medicine for the treatment of facial spasm newly, meet clinical needs.
(2) Chinese drug preparation for the treatment of facial spasm is become granule by the present invention, has both maintained decoction and has absorbed fast, effective feature rapidly, overcomes again before decoction is taken and interim to decoct, and is long placed in easily mouldly to lose rotten shortcoming, and can cover the bitterness of Chinese medicine.Chinese medicine granules Chinese crude drug of the present invention all through refining extraction, volume-diminished, transporting, carrying, taking convenience.
(3) clinical test results shows, the routine patient for the treatment of group 30 of the present invention fully recover 16 example, take a turn for the better 12 example, invalid 2 example, cure rate is 53.3%, and total effective rate is 93.3%; The routine patient of matched group 30 fully recover 7 example, take a turn for the better 17 example, invalid 6 example, cure rate is 23.2%, and total effective rate is 80%; 2 groups of cure rates have pole significant difference (P < 0.01), and total effective rate compares significant difference (P < 0.05).Matched group has 6 routine patients and occurs the symptom such as dizziness, Nausea and vomiting, erythra, abdominal distention, blurred vision in various degree, and above-mentioned untoward reaction does not all appear in treatment group.2 groups of adverse reaction rates compare significant difference (P < 0.05).
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Prescription
Rhizoma alpiniae pumilae 300g, Radix et rhizoma smilacinae japonicae 150g, Radix Zanthoxyli Spinifolii 250g, teacher ancestral fiber crops 60g, Radix Saposhnikoviae 150g, Herba Polygoni Runcinati 60g, tetramerous jasminorange leaf 60g, Scolopendra 30g, Bombyx Batryticatus 90g, Radix Clematidis 60g, Radix Astragali 300g, Rhizoma Atractylodis Macrocephalae 300g, Radix Angelicae Sinensis 150g, Radix Glycyrrhizae 90g.
Preparation method:
A () is by Rhizoma alpiniae pumilae, Radix et rhizoma smilacinae japonicae, Radix Zanthoxyli Spinifolii, Shi Zuma, Radix Saposhnikoviae, Herba Polygoni Runcinati, tetramerous jasminorange leaf, Radix Angelicae Sinensis 75% soak with ethanol of medical material volume 4 times amount reflux, extract, 2 times after 12 hours, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.05 ~ 0.07MPa for filtrate, and 60 DEG C are evaporated to the clear paste that relative density is 1.20 ~ 1.25;
B Scolopendra, Bombyx Batryticatus, Radix Clematidis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae 6 taste medical material are added the soak by water 2 times of above-mentioned medical material 7 times of weight by (), each decoction hour, merge the fried liquid of twice, the half that former fried liquid is long-pending is evaporated at 60 DEG C, incline and to cool, cold preservation 12 hours, filter, filtrate 60 DEG C is evaporated to the clear paste that relative density is 1.25 ~ 1.28;
C () merges two parts clear paste, mixing, and drying under reduced pressure is pulverized, and crosses 100 mesh sieves, is prepared into extract powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule 1000g, to obtain final product.
Prepare granule 100 bags altogether, every bag heavy 10g.
Usage and dosage: each 1 bag, every day 3 times.
Embodiment 2
Prescription
Rhizoma alpiniae pumilae 270g, Radix et rhizoma smilacinae japonicae 170g, Radix Zanthoxyli Spinifolii 230g, teacher ancestral fiber crops 70g, Radix Saposhnikoviae 130g, Herba Polygoni Runcinati 70g, tetramerous jasminorange leaf 50g, Scolopendra 3.50g, Bombyx Batryticatus 70g, Radix Clematidis 70g, Radix Astragali 270g, Rhizoma Atractylodis Macrocephalae 330g, Radix Angelicae Sinensis 130g, Radix Glycyrrhizae 110g.
Preparation method
Preparation method:
A () is by Rhizoma alpiniae pumilae, Radix et rhizoma smilacinae japonicae, Radix Zanthoxyli Spinifolii, Shi Zuma, Radix Saposhnikoviae, Herba Polygoni Runcinati, tetramerous jasminorange leaf, Radix Angelicae Sinensis 75% soak with ethanol of medical material volume 5 times amount reflux, extract, 2 times after 10 hours, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.05 ~ 0.07MPa for filtrate, and 60 DEG C are evaporated to the clear paste that relative density is 1.20 ~ 1.25;
B Scolopendra, Bombyx Batryticatus, Radix Clematidis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae 6 taste medical material are added the soak by water 2 times of above-mentioned medical material 6 times of weight by (), each decoction 0.5 hour, merge the fried liquid of twice, the half that former fried liquid is long-pending is evaporated at 60 DEG C, incline and to cool, cold preservation 12 hours, filter, filtrate 60 DEG C is evaporated to the clear paste that relative density is 1.25 ~ 1.28;
C () merges two parts clear paste, mixing, and drying under reduced pressure is pulverized, and crosses 100 mesh sieves, is prepared into extract powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule 1000g, to obtain final product.
Prepare granule 100 bags altogether, every bag heavy 10g.
Usage and dosage: each 1 bag, every day 3 times.
Embodiment 3
Prescription
Rhizoma alpiniae pumilae 330g, Radix et rhizoma smilacinae japonicae 130g, Radix Zanthoxyli Spinifolii 270g, teacher ancestral fiber crops 50g, Radix Saposhnikoviae 170g, Herba Polygoni Runcinati 50g, tetramerous jasminorange leaf 70g, Scolopendra 2.50g, Bombyx Batryticatus 110g, Radix Clematidis 50g, Radix Astragali 330g, Rhizoma Atractylodis Macrocephalae 270g, Radix Angelicae Sinensis 170g, Radix Glycyrrhizae 70g.
Preparation method:
A () is by Rhizoma alpiniae pumilae, Radix et rhizoma smilacinae japonicae, Radix Zanthoxyli Spinifolii, Shi Zuma, Radix Saposhnikoviae, Herba Polygoni Runcinati, tetramerous jasminorange leaf, Radix Angelicae Sinensis 75% soak with ethanol of medical material volume 35 times amount reflux, extract, 2 times after 14 hours, each 1 hour, filter, merging filtrate, decompression recycling ethanol is to medicinal liquid without alcohol taste under 0.05 ~ 0.07MPa for filtrate, and 60 DEG C are evaporated to the clear paste that relative density is 1.20 ~ 1.25;
B Scolopendra, Bombyx Batryticatus, Radix Clematidis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae 6 taste medical material are added the soak by water 2 times of above-mentioned medical material 8 times of weight by (), each decoction 1.5 hours, merge the fried liquid of twice, the half that former fried liquid is long-pending is evaporated at 60 DEG C, incline and to cool, cold preservation 12 hours, filter, filtrate 60 DEG C is evaporated to the clear paste that relative density is 1.25 ~ 1.28;
C () merges two parts clear paste, mixing, and drying under reduced pressure is pulverized, and crosses 100 mesh sieves, is prepared into extract powder, add sucrose, mixing, make wetting agent with 75% ethanol and granulate, dry, granulate, makes granule 1000g, to obtain final product.
Prepare granule 100 bags altogether, every bag heavy 10g.
Usage and dosage: each 1 bag, every day 3 times.
Embodiment 4
Prescription
Rhizoma alpiniae pumilae 250g, Radix et rhizoma smilacinae japonicae 200g, Radix Zanthoxyli Spinifolii 200g, teacher ancestral fiber crops 80g, Radix Saposhnikoviae 100g, Herba Polygoni Runcinati 80g, tetramerous jasminorange leaf 40g, Scolopendra 40g, Bombyx Batryticatus 60g, Radix Clematidis 80g, Radix Astragali 250g, Rhizoma Atractylodis Macrocephalae 350g, Radix Angelicae Sinensis 100g, Radix Glycyrrhizae 120g.
Preparation method is with embodiment 1.
Embodiment 5
Prescription
Rhizoma alpiniae pumilae 350g, Radix et rhizoma smilacinae japonicae 100g, Radix Zanthoxyli Spinifolii 300g, teacher ancestral fiber crops 40g, Radix Saposhnikoviae 200g, Herba Polygoni Runcinati 40g, tetramerous jasminorange leaf 80g, Scolopendra 20g, Bombyx Batryticatus 120g, Radix Clematidis 40g, Radix Astragali 350g, Rhizoma Atractylodis Macrocephalae 250g, Radix Angelicae Sinensis 200g, Radix Glycyrrhizae 60g.
Preparation method is with embodiment 1.
Carried out clinical pharrnacokinetics test to the preparation of embodiments of the invention l, result is as follows:
Physical data
60 routine facial spasm patients, all from this Out-patient Department or inpatient, meet pure " facial spasm " diagnosis.Outlet face tension syndrome, medicine causes the tension change of facial expression muscle, gets rid of cerebellopontine angle tumours Secondary cases facial spasm and other Intracranial Diseases.Adopt random digits table that patient is divided into 2 groups at random: treatment group 30 example, man 14 example, female 15 example; Year at age (36.6 ± 6.8), individual month of the course of disease (7.2 ± 4.1); Matched group 30 example, man 12 example, female 18 example; Year at age (35.9 ± 6.3), the course of disease (6.9 ± 4.4 months.Difference (P > 0.05) that 2 groups of physical data compare that there are no significant, has comparability.
Therapeutic Method
The oral carbamazepine of matched group (production of Beijing dawn Pharmaceutical Co) 200mg/d, 3 times/d.
The Chinese medicine for the treatment of facial spasm prepared by the oral embodiment of the present invention 1 for the treatment of group, each 1 bag, every day 3 times, one after each meal.Within 10 days, be 1 course for the treatment of, observe the curative effect after 1 course for the treatment of.
Observational technique
Observe weekly the improvement situation of clinical symptoms of attack times, persistent period, attack degree, observing clinical adverse, 12 weeks is 1 course for the treatment of.
Efficacy assessment standard
Spasm strength grading standard: 0 grade, without spasm; 1 grade, outside stimulus causes slight spasm; 2 grades, slight spasm, visible facial muscle twitches, nonfunctional obstacle; 3 grades, moderate spasm, facial spasm is obvious, has slight dysfunction; 4 grades, severe spasm, has severe dysfunction, affects work and life.Cure: transference cure, spasm is classified as 0 grade, without recurrence in March; Take a turn for the better: symptom obviously alleviates, and spasm frequency, amplitude all obviously reduce, spasm classification declines and is greater than 1 grade
Statistical procedures
Adopt SPSS10.5 statistical software, enumeration data X 2 test; Measurement data mean ± standard deviation (x ± s) represents, adopts t inspection.
Result is the results detailed in Table 1.
Table 1 treatment group and matched group comparitive study
| Group | Cure | Effectively | Invalid | Cure rate (%) | Total effective rate (%) |
| Treatment group (30) | 16 | 12 | 2 | 53.3 ** | 93.3 * |
| Matched group (30) | 7 | 17 | 6 | 23.3 | 80 |
Note:
*compare with matched group, P<O.01;
*compare with matched group, P<O.05.
The routine patient for the treatment of group 30 fully recover 16 example, take a turn for the better 12 example, invalid 2 example, cure rate is 53.3%, and total effective rate is 93.3%; The routine patient of matched group 30 fully recover 7 example, take a turn for the better 17 example, invalid 6 example, cure rate is 23.2%, and total effective rate is 80%; 2 groups of cure rates have pole significant difference (P < 0.01), and total effective rate compares significant difference (P < 0.05).
Matched group has 6 routine patients and occurs the symptom such as dizziness, Nausea and vomiting, erythra, abdominal distention, blurred vision in various degree, and above-mentioned untoward reaction does not all appear in treatment group.2 groups of adverse reaction rates compare significant difference (P < 0.05).
Claims (4)
1. treat a Chinese medicine for facial spasm, be made up of the raw material of Chinese medicine medicine of following weight portion:
Rhizoma alpiniae pumilae 25-35 part, Radix et rhizoma smilacinae japonicae 10-20 part, Radix Zanthoxyli Spinifolii 20-30 part, teacher ancestral fiber crops 4-8 part, Radix Saposhnikoviae 10-20 part, Herba Polygoni Runcinati 4-8 part, tetramerous jasminorange leaf 4-8 part, Scolopendra 2-4 part, Bombyx Batryticatus 6-12 part, Radix Clematidis 4-8 part, Radix Astragali 25-35 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Radix Angelicae Sinensis 10-20 part, Radix Glycyrrhizae 6-12 part.
2. the Chinese medicine for the treatment of facial spasm according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight portion:
Rhizoma alpiniae pumilae 27-33 part, Radix et rhizoma smilacinae japonicae 13-17 part, Radix Zanthoxyli Spinifolii 23-27 part, teacher ancestral fiber crops 5-7 part, Radix Saposhnikoviae 13-17 part, Herba Polygoni Runcinati 5-7 part, tetramerous jasminorange leaf 5-7 part, Scolopendra 2.5-3.5 part, Bombyx Batryticatus 7-11 part, Radix Clematidis 5-7 part, Radix Astragali 27-33 part, Rhizoma Atractylodis Macrocephalae 27-33 part, Radix Angelicae Sinensis 13-17 part, Radix Glycyrrhizae 7-11 part.
3. the Chinese medicine for the treatment of facial spasm according to claim 2, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight portion:
Rhizoma alpiniae pumilae 30 parts, Radix et rhizoma smilacinae japonicae 15 parts, Radix Zanthoxyli Spinifolii 25 parts, teacher ancestral fiber crops 6 parts, Radix Saposhnikoviae 15 parts, Herba Polygoni Runcinati 6 parts, tetramerous jasminorange leaf 6 parts, Scolopendra 3 parts, Bombyx Batryticatus 9 parts, Radix Clematidis 6 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Radix Angelicae Sinensis 15 parts, 9 parts, Radix Glycyrrhizae.
4. the Chinese medicine of the treatment facial spasm according to claim 1 or 2 or 3, is characterized in that, the dosage form of this Chinese medicine is granule.
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| CN1544051A (en) * | 2003-11-24 | 2004-11-10 | 游国峰 | Chinese traditional medicine for treating facial paralysis, facial spasm and trifacial neuralgia |
| CN1785370A (en) * | 2005-11-15 | 2006-06-14 | 唐浩 | Medicine for treating facial paralysis spasm |
| CN1785409A (en) * | 2005-11-17 | 2006-06-14 | 西安千禾药业有限责任公司 | Medicine for treating epilepsy clonus, child convulsion, prosopospasm and its preparation method |
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| CN1544051A (en) * | 2003-11-24 | 2004-11-10 | 游国峰 | Chinese traditional medicine for treating facial paralysis, facial spasm and trifacial neuralgia |
| CN1785370A (en) * | 2005-11-15 | 2006-06-14 | 唐浩 | Medicine for treating facial paralysis spasm |
| CN1785409A (en) * | 2005-11-17 | 2006-06-14 | 西安千禾药业有限责任公司 | Medicine for treating epilepsy clonus, child convulsion, prosopospasm and its preparation method |
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