CN103463584B - Peptic ulcer treatment traditional Chinese medicine composition and preparation method thereof - Google Patents

Peptic ulcer treatment traditional Chinese medicine composition and preparation method thereof Download PDF

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CN103463584B
CN103463584B CN201310342074.9A CN201310342074A CN103463584B CN 103463584 B CN103463584 B CN 103463584B CN 201310342074 A CN201310342074 A CN 201310342074A CN 103463584 B CN103463584 B CN 103463584B
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chinese medicine
medicine composition
radix
peptic ulcer
rhizoma
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CN103463584A (en
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马其胜
陈华彪
张勇
尹群
孙鹏
朱学娟
李保琴
吕式军
杨进辉
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Anhui BBCA Pharmaceutical Co Ltd
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Anhui BBCA Pharmaceutical Co Ltd
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Abstract

The present invention provides a peptic ulcer treatment traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following bulk drugs: corydalis tuber, dan-shen root, dried ginger, cassia bark, tangerine peel, costusroot, licorice root, dangshen, common bletilla tuber, cuttlebone and ansu apricot seed. The peptic ulcer treatment traditional Chinese medicine composition has characteristics of definite therapeutic effect, low recurrence rate, low cost and strong antibacterial effect, and can be used as an ideal peptic ulcer treatment drug.

Description

Chinese medicine composition for the treatment of peptic ulcer and preparation method thereof
Technical field
The present invention relates to Chinese medicine composition field, specifically, relate to a kind of Chinese medicine composition for the treatment of peptic ulcer and preparation method thereof.
Background technology
Modern medicine is thought, peptic ulcer refers to gastric duodenal ulcer, in gastroesophageal reflux disease, be also shown in esophageal peptic ulcer, is also shown in the peptic ulcer of ileum far-end in Meckel diverticulum patient.It is generally acknowledged that the mucosa injury factor (gastric acid, pepsin and helicobacter pylori etc.) and protective factors (Gastric Mucosa Blood Flow amount, mucus barrier and prostaglandin) are in poised state; once damage factor effect reinforcement or protective factors declines, all peptic ulcer can be caused.The most important reason of peptic ulcer disease is caused to be that gastric antrum portion Hp infects, caused by the duodenal ulcer of about 90% and the gastric ulcer of 80% infect by Hp.The external factor of peptic ulcer is caused to have: heredity, geographical environment, spirit, diet, smoking, medicine and chemicals (such as, NSAID (non-steroidal anti-inflammatory drug) and antiplatelet drug) etc.
Motherland's medical science is thought, peptic ulcer belongs to " gastric abscess ", " syndrome of feeling fullness and distension in the upper abdomen ", " noisy ", the category such as " acid regurgitation ", the factor such as inappropriate and body constitution of its pathogenic factor and diseases caused by exogenous pathogenic factor six climate exopathogens, internal damage by the excessive seven emotions, daily life is closely related.Its course of disease is long, recurrent exerbation, meets the traditional Chinese medical science " prolonged illness must empty ", saying of " prolonged illness must the stasis of blood ".Many because of drinking and eating irregularly, angry resentment of being worried, pathogenic fire derived from stagnation of liver-QI, the bright stomach-Yin of heat, cause gastric mucosa impaired; Or, insufficiency of the spleen mistake fortune, damp cohesion, corrosion body of stomach, with the passing of time puzzled, all can cause the generation of Peptic Ulcers.Stagnation of QI due to depression of the liver, taste are become estranged, disorder of QI movement, and it is this pathogenetic basic pathogenesis that stomach mistake is moistened foster.Gastric qi blocks, stomach-QI being unable to descend normally, " stagnation of QI and blood may bring about pain "; Cold-evil's impairment of YANG, spleen YANG deficiency, the stomach failing to be warmed; YIN damaged by pathogenic heat, deficiency of stomach-Yin, stomach mistake is moistened foster, " not Rong Ze pain ".
Medicament for resisting peptic ulcer plays antiulcer action by impact damage or protective factors, is mainly divided into four classes: (1) antacid, and conventional alkalescence inorganic salt, can neutralize too much gastric acid after oral, raises gastric pH, eliminates the stimulation infringement of gastric acid; PH raises and suppresses peptic activity of stomach again simultaneously.(2) H 2receptor antagonist, specific inhibition parietal cell H 2receptor, gastric acid secretion inhibiting.(3) parietal cell H +pump depressant, oral rear and coat of the stomach H +pump (proton pump) combines, and suppresses H +pump, reduces gastric acid secretion.Stronger inhibitory action is all had to the gastric acid secretion that basal gastric acid secretion and histamine, gastrin, food etc. cause.Act on length of holding time, also can have anti-helicobacter pylori effect.(4) mucosa protection medicine, can protect the Mucosa Barrier of damage.
But the modern medicines of existing treatment peptic ulcer have following deficiency: 1) antacid uncertain therapeutic efficacy is cut, side effect is large, and life-time service is often with untoward reaction, and as diarrhoea or constipation, all antacid all produce temporary compensatory hydrochloric acid secretion to be increased.2) H 2receptor antagonist should not use part special population, and as gestation and women breast-feeding their children, acute pancreatitis person, has allergies, hepatic and kidney function obstacle person and child, serious heart and respiratory system disease, systemic lupus erythematosus (sle), encephalosis person.3) H +pump depressant, mainly contains headache, drowsiness and gastrointestinal symptom, occasionally has erythra, peripheral nervous inflammation, abnormal liver function and gynecomastia etc.To pregnant and women breast-feeding their children, child's forbidding; Long term maintenance therapy should not be used for; Be cautious use of having drug allergy history person, hepatic insufficiency patient and People.4) Drug therapy of effecting a radical cure Hp infection easily causes the general drug resistance of bacterial antibiotic.5) after treatment, the relapse rate of peptic ulcer is higher.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of peptic ulcer and preparation method thereof.
In order to realize the object of the invention, a kind of Chinese medicine composition for the treatment of peptic ulcer of the present invention, is made up of following crude drug: Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Rhizoma Zingiberis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Radix Glycyrrhizae, Radix Codonopsis, Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae and Semen Armeniacae Amarum.
The Chinese medicine composition for the treatment of peptic ulcer of the present invention, is made up of the crude drug of following weight portion: Rhizoma Corydalis 28-52, Radix Salviae Miltiorrhizae 42-78, Rhizoma Zingiberis 21-39, Cortex Cinnamomi 21-39, Pericarpium Citri Reticulatae 35-65, Radix Aucklandiae 17-33, Radix Glycyrrhizae 17-33, Radix Codonopsis 42-78, Pseudobulbus Bletillae (Rhizoma Bletillae) 56-104, Endoconcha Sepiae 56-104 and Semen Armeniacae Amarum 14-26.
Preferably, the Chinese medicine composition for the treatment of peptic ulcer of the present invention, is made up of the crude drug of following weight portion: Rhizoma Corydalis 32-48, Radix Salviae Miltiorrhizae 48-72, Rhizoma Zingiberis 24-36, Cortex Cinnamomi 24-36, Pericarpium Citri Reticulatae 40-60, Radix Aucklandiae 20-30, Radix Glycyrrhizae 20-30, Radix Codonopsis 48-72, Pseudobulbus Bletillae (Rhizoma Bletillae) 64-96, Endoconcha Sepiae 64-96 and Semen Armeniacae Amarum 16-24.
More preferably, the Chinese medicine composition for the treatment of peptic ulcer of the present invention, is made up of the crude drug of following weight portion: Rhizoma Corydalis 40, Radix Salviae Miltiorrhizae 60, Rhizoma Zingiberis 30, Cortex Cinnamomi 30, Pericarpium Citri Reticulatae 50, the Radix Aucklandiae 25, Radix Glycyrrhizae 25, Radix Codonopsis 60, Pseudobulbus Bletillae (Rhizoma Bletillae) 80, Endoconcha Sepiae 80 and Semen Armeniacae Amarum 20.
The present invention also provides the method preparing above-mentioned Chinese medicine composition, comprises the following steps:
1) Radix Salviae Miltiorrhizae, Endoconcha Sepiae and the Radix Aucklandiae are worn into coarse powder, then by coarse powder and Rhizoma Corydalis, Cortex Cinnamomi alcohol reflux, filter, decompression filtrate recycling ethanol, obtains ethanol concentrated solution;
2), after Semen Armeniacae Amarum being smashed to pieces, soak together with Pseudobulbus Bletillae (Rhizoma Bletillae) with Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Radix Codonopsis; By the medical material water extraction in the medical material after immersion and step 1) after alcohol reflux, filter, concentrated filtrate, obtains filtrate concentrated solution; The volatile oil obtained in water extraction process collected by another device simultaneously;
3) above-mentioned ethanol concentrated solution and filtrate concentrated solution are merged, be condensed into thick paste;
4) volatile oil and thick paste are merged, to obtain final product.
In aforementioned preparation process, in step 1), the concrete grammar of alcohol reflux is: the concentration adding 8-12 times of medical material weight is the ethanol of 70%-90%, heating and refluxing extraction 1h-4h, filters, decompression filtrate recycling ethanol.
In aforementioned preparation process, step 2) in medical material is soaked (not having medical material to be advisable with water logging) 8-24h before water extraction.The method of water extraction is specially: use water extraction 2-3 time, add the water of 6-12 times of medical material weight, each decocting time is 1-3h at every turn; After decoction, filter, merging filtrate, be evaporated to appropriate.Collect volatile oil, another device is deposited, for subsequent use simultaneously.
Preferably, step 2) in the method for water extraction be specially: extracting in water 3 times, adds the soak by water 1.5h of 10 times of medical material weight for the 1st time, adds the soak by water 1h of 8 times of medical material weight for the 2nd time and the 3rd time respectively.
The method preparing Chinese medicine composition of the present invention can also be: ratio is taken above ten a herb materials, be directly ground into fine powder, be used as medicine with powder.
The present invention also provides the preparation containing described Chinese medicine composition, and described Chinese medicine composition or its preparation are capsule, tablet, powder, pill, decoction, mixture or granule etc.
The present invention further provides the application in the medicine for the preparation for the treatment of peptic ulcer in described Chinese medicine composition.Described peptic ulcer refers to gastric duodenal ulcer, esophageal peptic ulcer, ileum far-end peptic ulcer etc.
The compatibility of medicines in a prescription of Chinese medicine composition provided by the invention:
Endoconcha Sepiae treating spontaneous emission and leukorrhagia, astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore is monarch drug.
Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation, Pseudobulbus Bletillae (Rhizoma Bletillae) joins Endoconcha Sepiae, and hemostasis power is strong, promotes ulcer healing, controls the haematemesis of peptic ulcer, effect of having blood in stool is good; Rhizoma Corydalis, Radix Salviae Miltiorrhizae promoting blood circulation to disperse blood clots and relieves pain; Pericarpium Citri Reticulatae, Radix Aucklandiae circulation of qi promoting stomach invigorating, eliminate symptom, and it is solid basic to mend, and is ministerial drug altogether.
Semen Armeniacae Amarum loosening bowel to relieve constipation; Rhizoma Zingiberis warming middle-JIAO, recuperating depleted YANG, warming the lung to resolve fluid-retention; It is supporing yang that Cortex Cinnamomi mends fire, and guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian is adjuvant drug altogether.
The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, expelling phlegm for arresting cough, removing toxic substances, relieving spasm to stop pain, relaxes the property of medicine; Radix Codonopsis invigorating the spleen and replenishing QI, spermatogenesis nourishes blood, altogether for making medicine.
The research of modern pharmacology effect shows:
Rhizoma Corydalis: analgesia, antiulcer etc.
Radix Salviae Miltiorrhizae: improve microcirculation, immunity moderation function, antiinflammatory, antibacterial etc.
Rhizoma Zingiberis: strengthen function of intestinal canal, facilitating digestion, antiulcer, protection gastric mucosa, analgesia, antiinflammatory, improves immunologic function, antibacterial etc.
Cortex Cinnamomi: antiulcer, analgesia, antiinflammatory, antibacterial etc.
Pericarpium Citri Reticulatae: suppress gastrointestinal smooth muscle, anti-gastric-ulcer, antiinflammatory, antibacterial etc.
The Radix Aucklandiae: adjustment gastrointestinal motility, anti-peptic ulcer, analgesia, antibacterial etc.
Radix Glycyrrhizae: anti-peptic ulcer, removing toxic substances, antiinflammatory, antibacterial etc.
Radix Codonopsis: regulate gastrointestinal function, protection gastric mucosa, promotes the healing of gastric ulcer, enhancing human body immunity function, antibacterial etc.
Pseudobulbus Bletillae (Rhizoma Bletillae): improve microcirculation, protection gastric mucosa, anti-peptic ulcer, antibacterial.
Endoconcha Sepiae: anti-peptic ulcer, in and gastric acid, change gastric content pH value, reduce pepsin activity, promote ulcer surface healing, ulcer surface forms protecting film.
Semen Armeniacae Amarum: suppress pepsin activity etc.
The present invention has the following advantages:
(1) Chinese medicine composition provided by the invention is a kind of novel treatment Antiulcer drugs, and treating both the principal and secondary aspects of a disease, determined curative effect, cost is low.
(2) this product has stronger antibacterial action, can suppress and kill helicobacter pylori, reaches the object for the treatment of peptic ulcer.
(3) because Chinese medicine composition of the present invention is not containing modern medicines, decrease medicine contraindication, reduce untoward reaction, expand medication crowd.
(4) generation of Resistant strain is not easily caused.
(5) cure rate is high, and relapse rate is low.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.If do not specialize, the conventional means that technological means used in embodiment is well known to those skilled in the art, is raw materials usedly commercial goods.
Embodiment 1 treats the Chinese medicine composition of peptic ulcer
1, Chinese crude drug formula is in table 1:
Table 1 Chinese crude drug formula
Chinese crude drug Weight (kg) Percentage by weight (%)
Rhizoma Corydalis 40 8
Radix Salviae Miltiorrhizae 60 12
Rhizoma Zingiberis 30 6
Cortex Cinnamomi 30 6
Pericarpium Citri Reticulatae 50 10
The Radix Aucklandiae 25 5
Radix Glycyrrhizae 25 5
Radix Codonopsis 60 12
Pseudobulbus Bletillae (Rhizoma Bletillae) 80 16
Endoconcha Sepiae 80 16
Semen Armeniacae Amarum 20 4
Add up to 500 100
2, preparation method:
1) above ten Herba indigoferae Pseudotinctoriae are taken by table 1 formula.
2) Radix Salviae Miltiorrhizae, Endoconcha Sepiae and Radix Aucklandiae powder are broken into coarse powder, concentration coarse powder and Rhizoma Corydalis, Cortex Cinnamomi being added 10 times of medical material weight is the ethanol of 80%, heating and refluxing extraction 3h, and filter, decompression filtrate recycling ethanol, obtains ethanol concentrated solution.
3), after being smashed to pieces by Semen Armeniacae Amarum, 8h is soaked with Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Radix Codonopsis together with Pseudobulbus Bletillae (Rhizoma Bletillae).
4) by the medical material after soaking in step 3) and step 2) in medical material after alcohol reflux water extraction 3 times, add the soak by water 1.5h of 10 times of medical material weight for 1st time, add the soak by water 1h of 8 times of medical material weight for the 2nd time and the 3rd time respectively, collect volatile oil, another device is deposited, for subsequent use.Filter, merging filtrate, be evaporated to appropriate, obtain filtrate concentrated solution.
5) above-mentioned ethanol concentrated solution and filtrate concentrated solution merged, being concentrated into relative density is 1.25 ~ 1.30(80 DEG C) thick paste, for subsequent use.
6) by the volatile oil of gained and thick paste mixing, technique is prepared into capsule routinely.
Embodiment 2 treats the Chinese medicine composition of peptic ulcer
1, Chinese crude drug formula is in table 2:
Table 2 Chinese crude drug formula
Chinese crude drug Weight (kg) Percentage by weight (%)
Rhizoma Corydalis 52 10.46
Radix Salviae Miltiorrhizae 42 8.45
Rhizoma Zingiberis 39 7.85
Cortex Cinnamomi 21 4.23
Pericarpium Citri Reticulatae 65 13.08
The Radix Aucklandiae 17 3.42
Radix Glycyrrhizae 33 6.64
Radix Codonopsis 42 8.45
Pseudobulbus Bletillae (Rhizoma Bletillae) 104 20.93
Endoconcha Sepiae 56 11.27
Semen Armeniacae Amarum 26 5.23
Add up to 497 100
2, preparation method:
1) above ten Herba indigoferae Pseudotinctoriae are taken by table 2 formula.
2) Radix Salviae Miltiorrhizae, Endoconcha Sepiae and Radix Aucklandiae powder are broken into coarse powder, the concentration that coarse powder and Rhizoma Corydalis, Cortex Cinnamomi add 8 times of medical material weight is the ethanol of 90%, heating and refluxing extraction 2h, and filter, decompression filtrate recycling ethanol, obtains ethanol concentrated solution.
3), after being smashed to pieces by Semen Armeniacae Amarum, 12h is soaked with Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Radix Codonopsis together with Pseudobulbus Bletillae (Rhizoma Bletillae).
4) by the medical material after soaking in step 3) and step 2) in medical material after alcohol reflux water extraction 2 times, add the soak by water 3h of 8 times of medical material weight for the 1st time, add the soak by water 2h of 6 times of medical material weight for the 2nd time, collect volatile oil, another device is deposited, for subsequent use.Filter, merging filtrate, be evaporated to appropriate, obtain filtrate concentrated solution.
5) above-mentioned ethanol concentrated solution and filtrate concentrated solution merged, being concentrated into relative density is 1.25 ~ 1.30(80 DEG C) thick paste, for subsequent use.
6) by the volatile oil of gained and thick paste mixing, technique is prepared into tablet routinely.
Embodiment 3 treats the Chinese medicine composition of peptic ulcer
1, Chinese crude drug formula is in table 3:
Table 3 Chinese crude drug formula
Chinese crude drug Weight (kg) Percentage by weight (%)
Rhizoma Corydalis 28 5.57
Radix Salviae Miltiorrhizae 78 15.51
Rhizoma Zingiberis 21 4.17
Cortex Cinnamomi 39 7.75
Pericarpium Citri Reticulatae 35 6.96
The Radix Aucklandiae 33 6.56
Radix Glycyrrhizae 17 3.38
Radix Codonopsis 78 15.51
Pseudobulbus Bletillae (Rhizoma Bletillae) 56 11.13
Endoconcha Sepiae 104 20.68
Semen Armeniacae Amarum 14 2.78
Add up to 503 100
2, preparation method:
1) above ten Herba indigoferae Pseudotinctoriae are taken by table 3 formula.
2) Radix Salviae Miltiorrhizae, Endoconcha Sepiae and Radix Aucklandiae powder are broken into coarse powder, concentration coarse powder and Rhizoma Corydalis, Cortex Cinnamomi being added 12 times of medical material weight is the ethanol of 80%, heating and refluxing extraction 4h, and filter, decompression filtrate recycling ethanol, obtains ethanol concentrated solution.
3), after being smashed to pieces by Semen Armeniacae Amarum, 16h is soaked with Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Radix Codonopsis together with Pseudobulbus Bletillae (Rhizoma Bletillae).
4) by the medical material after soaking in step 3) and step 2) in medical material after alcohol reflux water extraction 3 times, add the soak by water 2h of 12 times of medical material weight for 1st time, add the soak by water 1.5h of 10 times of medical material weight for 2nd time, add the soak by water 1h of 8 times of medical material weight for 3rd time, collect volatile oil, another device is deposited, for subsequent use.Filter, merging filtrate, be evaporated to appropriate, obtain filtrate concentrated solution.
5) above-mentioned ethanol concentrated solution and filtrate concentrated solution merged, being concentrated into relative density is 1.25 ~ 1.30(80 DEG C) thick paste, for subsequent use.
6) by the volatile oil of gained and thick paste mixing, technique is prepared into powder routinely.
Embodiment 4 treats the Chinese medicine composition of peptic ulcer
1, Chinese crude drug formula is in table 4:
Table 4 Chinese crude drug formula
Chinese crude drug Weight (kg) Percentage by weight (%)
Rhizoma Corydalis 48 9.64
Radix Salviae Miltiorrhizae 48 9.64
Rhizoma Zingiberis 36 7.23
Cortex Cinnamomi 24 4.82
Pericarpium Citri Reticulatae 60 12.05
The Radix Aucklandiae 20 4.02
Radix Glycyrrhizae 30 6.02
Radix Codonopsis 48 9.64
Pseudobulbus Bletillae (Rhizoma Bletillae) 96 19.28
Endoconcha Sepiae 64 12.85
Semen Armeniacae Amarum 24 4.82
Add up to 498 100
2, preparation method:
1) above ten Herba indigoferae Pseudotinctoriae are taken by table 4 formula.
2) Radix Salviae Miltiorrhizae, Endoconcha Sepiae and Radix Aucklandiae powder are broken into coarse powder, concentration coarse powder and Rhizoma Corydalis, Cortex Cinnamomi being added 9 times of medical material weight is the ethanol of 70%, heating and refluxing extraction 3h, and filter, decompression filtrate recycling ethanol, obtains ethanol concentrated solution.
3), after being smashed to pieces by Semen Armeniacae Amarum, 20h is soaked with Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Radix Codonopsis together with Pseudobulbus Bletillae (Rhizoma Bletillae).
4) by the medical material after soaking in step 3) and step 2) in medical material after alcohol reflux water extraction 2 times, add the soak by water 2h of 12 times of medical material weight for 1st time, add the soak by water 1.5h of 10 times of medical material weight for the 2nd time, collect volatile oil, another device is deposited, for subsequent use.Filter, merging filtrate, be evaporated to appropriate, obtain filtrate concentrated solution.
5) above-mentioned ethanol concentrated solution and filtrate concentrated solution merged, being concentrated into relative density is 1.25 ~ 1.30(80 DEG C) thick paste, for subsequent use.
6) by the volatile oil of gained and thick paste mixing, technique is prepared into pill routinely.
Embodiment 5 treats the Chinese medicine composition of peptic ulcer
1, Chinese crude drug formula is in table 5:
Table 5 Chinese crude drug formula
Chinese crude drug Weight (kg) Percentage by weight (%)
Rhizoma Corydalis 32 6.37
Radix Salviae Miltiorrhizae 72 14.34
Rhizoma Zingiberis 24 4.78
Cortex Cinnamomi 36 7.17
Pericarpium Citri Reticulatae 40 7.97
The Radix Aucklandiae 30 5.98
Radix Glycyrrhizae 20 3.98
Radix Codonopsis 72 14.34
Pseudobulbus Bletillae (Rhizoma Bletillae) 64 12.75
Endoconcha Sepiae 96 19.12
Semen Armeniacae Amarum 16 3.19
Add up to 502 100
2, preparation method:
1) above ten Herba indigoferae Pseudotinctoriae are taken by table 5 formula.
2) Radix Salviae Miltiorrhizae, Endoconcha Sepiae and Radix Aucklandiae powder are broken into coarse powder, concentration coarse powder and Rhizoma Corydalis, Cortex Cinnamomi being added 11 times of medical material weight is the ethanol of 80%, heating and refluxing extraction 2h, and filter, decompression filtrate recycling ethanol, obtains ethanol concentrated solution.
3), after being smashed to pieces by Semen Armeniacae Amarum, 24h is soaked with Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Radix Codonopsis together with Pseudobulbus Bletillae (Rhizoma Bletillae).
4) by the medical material after soaking in step 3) and step 2) in medical material after alcohol reflux water extraction 3 times, add the soak by water 3h of 10 times of medical material weight for 1st time, add the soak by water 1h of 8 times of medical material weight for 2nd time, add the soak by water 1h of 6 times of medical material weight for 3rd time, collect volatile oil, another device is deposited, for subsequent use.Filter, merging filtrate, be evaporated to appropriate, obtain filtrate concentrated solution.
5) above-mentioned ethanol concentrated solution and filtrate concentrated solution merged, being concentrated into relative density is 1.25 ~ 1.30(80 DEG C) thick paste, for subsequent use.
6) by the volatile oil of gained and thick paste mixing, technique is prepared into granule routinely.
Embodiment 6 treats the Chinese medicine composition of peptic ulcer
1, Chinese crude drug formula is in table 6:
Table 6 Chinese crude drug formula
Chinese crude drug Weight (kg) Percentage by weight (%)
Rhizoma Corydalis 40 8
Radix Salviae Miltiorrhizae 60 12
Rhizoma Zingiberis 30 6
Cortex Cinnamomi 30 6
Pericarpium Citri Reticulatae 50 10
The Radix Aucklandiae 25 5
Radix Glycyrrhizae 25 5
Radix Codonopsis 60 12
Pseudobulbus Bletillae (Rhizoma Bletillae) 80 16
Endoconcha Sepiae 80 16
Semen Armeniacae Amarum 20 4
Add up to 500 100
2, preparation method:
Take above ten Herba indigoferae Pseudotinctoriae by table 6 formula, be ground into fine powder, mix homogeneously.Technique is prepared into tablet routinely.
The curative effect of the Chinese medicine composition of embodiment 7 treatment peptic ulcer of the present invention
1, case selection
1) diagnostic criteria
Western medicine diagnose standard: the periodicity of prolonged and repeated generation, the chronic epigastrium pain of rhythmicity, using basic medicine can be alleviated; Epigastrium has limitation deeply in tenderness; X-ray canel barium meal contrast examination is shown in Ulcer niche; Splanchnoscopy can see active stage ulcer.
TCM syndrome diagnostic criteria: syndrome of stagnation of QI: primary symptom: epigastric distending pain, two side of body feeling of distension and oppression, chance feelings will is unsuccessful, increases the weight of, and belch or arrow gas then relax, susceptible to get angry, sighing frequently; Secondary disease: lack of appetite uncomfortable in chest, general acid regurgitation water, thin white fur of tongue, stringy pulse.Hot and suffocating card: primary symptom: gastric abscess gesture is urgent, has burning sensation, eats pain and obviously alleviate, or eat easy pain, xerostomia and bitter, red tongue with yellow fur, stringy pulse or number; Secondary disease: desire for cold drinks, acid regurgitation, noisy, be in a very depressed state or irritable, constipation.Yin deficiency syndrome: primary symptom: the indistinct causalgia of gastral cavilty, increases the weight of on an empty stomach, and like hunger but having no desire to eat, xerostomia is not for drink, and red tongue with a little fluid, has crackle, or few tongue, or exfoliative fur; Secondary disease: dry mouth and tougue, indigestion and loss of appetite retch, constipation with dry stool, feverish sensation in the palms and soles.Deficiency-cold syndrome: primary symptom: indistinctly, desire for warm and being pressed, whenever cold or tired easy outbreak or increase the weight of, pain of empty stomach weight, obtain food alleviation of pain, abdominal distention after meal, pale and tender tongue in stomachache, while there is indentation, white and thin fur, deep-thready pulse or late; Secondary disease: fatigue and weakness, spiritlessness and sparing of words, aversion to cold and cold limbs, the stool pool is thin.Blood stasis symptom: primary symptom: stomachache is as thorn as cut, pain in fixed position, body of the tongue purple is dim or have petechia, ecchymosis; Secondary disease: sharp ache, can pain thorough thoracic dorsal, cold extremities, sweating, hematemesis or melena history.
2) inclusive criteria
Meet peptic ulcer diagnostic criteria and TCM syndrome diagnostic criteria.In 1 week, fibrescope turns out to be ulcer active stage, ulcer diameter person between 2 ~ 3mm.
3) exclusion standard
Endoscope turns out to be giving a farfetched interpretation property ulcer, stomach bottom ulcer, gastric ulcer merging severe dysplasia person; There is complication in 30 days before the test and carry out operator; There is the gastric and duodenal ulcers of cause specific, as gastrinoma, hepatitis interstitialis chronica etc.; The women of gestation and preparation gestation, women breast-feeding their children; Allergic constitution or to multi-medicament allergy sufferers; There are other complication to affect the treatment and observe or have trial drug the disease of taboo; Indulge in excessive drinking or have other to be unfit to do drug test observer; Be associated with severe primary disease, the psychotics such as cardiovascular, liver, kidney and hemopoietic system.
2, case is collected and grouping
Choose suitable being in hospital and clinic case according to above standard, finally make a definite diagnosis cold patients 418 example, be divided into six groups at random:
Experimental example 1 group, 60 example, man 41 example, female 19 example, age 19-56 year, 35.6 years old mean age;
Experimental example 2 groups, 57 example, man 40 example, female 17 example, age 21-54 year, 37.5 years old mean age;
Experimental example 3 groups, 61 example, man 44 example, female 17 example, age 18-57 year, 35.2 years old mean age;
Experimental example 4 groups, 56 example, man 38 example, female 18 example, age 22-56 year, 37.1 years old mean age;
Experimental example 5 groups, 63 example, man 41 example, female 22 example, age 19-55 year, 38.0 years old mean age;
Experimental example 6 groups, 62 example, man 42 example, female 20 example, age 18-53 year, 36.9 years old mean age;
Matched group: 59 example, man 40 example, female 19 example, age 19-55 year, 39.0 years old mean age, experimental group and matched group data through statistical procedures without explicitly difference.
Wherein, embodiment 1-6 group gives the Chinese medicine composition prepared in embodiment of the present invention 1-6 respectively.Matched group: triple therapy, omeprazole enteric-coated capsules (SHANDONG LUOXIN PHARMACY STOCK Co., LTD.), Amoxicillin Capsules (Hainan Sanye Pharmaceutical Co., Ltd.), clarithromycin tablet (He'nan Tianfang Pharmaceutical Co., Ltd), treating 1 week is 1 course for the treatment of, terminate rear omeprazole consumption 2 courses for the treatment of to reduce by half, all the other medicines are constant, treat 4 courses for the treatment of continuously.
The all experimenters of treatments period do not add and treat with other drug.
3, efficacy assessment standard
1) gastroscopy effect criterion
Clinical recovery: ulcer and around inflammation all disappear.
Effective: ulcer disappears, and still has inflammation.
Effective: ulcer surface reduces more than 50%.
Invalid: ulcer surface reduces not as good as 50%.
2) therapeutic effect of syndrome criterion
Clinical recovery: symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: symptom, sign are all not improved, even increase the weight of, syndrome integral reduces less than 30%.
4, therapeutic outcome: in table 7.
Table 7 treatment group and matched group clinical curative effect analysis
Group Number of cases Recovery from illness Effective Effectively Invalid Effective percentage
Matched group 59 9 10 19 21 64.41%
Embodiment 1 group 60 12 13 22 13 78.33%
Embodiment 2 groups 57 11 12 22 12 78.95%
Embodiment 3 groups 61 14 15 18 14 77.05%
Embodiment 4 groups 56 12 13 18 13 76.79%
Embodiment 5 groups 63 16 14 18 15 76.19%
Embodiment 6 groups 62 18 15 17 12 80.65%
As can be seen from Table 7, the effective percentage for the treatment of of control group flu is only 64.41%, and uses the Chinese medicine composition effective percentage prepared in embodiment of the present invention 1-6 higher than 76%, and treatment group is significant difference (p<0.05) compared with matched group curative effect.Result shows: this product is in treatment peptic ulcer, and effect is better than existing therapy or medicine.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (9)

1. treat a Chinese medicine composition for peptic ulcer, described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Corydalis 28-52, Radix Salviae Miltiorrhizae 42-78, Rhizoma Zingiberis 21-39, Cortex Cinnamomi 21-39, Pericarpium Citri Reticulatae 35-65, Radix Aucklandiae 17-33, Radix Glycyrrhizae 17-33, Radix Codonopsis 42-78, Pseudobulbus Bletillae (Rhizoma Bletillae) 56-104, Endoconcha Sepiae 56-104 and Semen Armeniacae Amarum 14-26.
2. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Corydalis 32-48, Radix Salviae Miltiorrhizae 48-72, Rhizoma Zingiberis 24-36, Cortex Cinnamomi 24-36, Pericarpium Citri Reticulatae 40-60, Radix Aucklandiae 20-30, Radix Glycyrrhizae 20-30, Radix Codonopsis 48-72, Pseudobulbus Bletillae (Rhizoma Bletillae) 64-96, Endoconcha Sepiae 64-96 and Semen Armeniacae Amarum 16-24.
3. Chinese medicine composition according to claim 2, it is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: Rhizoma Corydalis 40, Radix Salviae Miltiorrhizae 60, Rhizoma Zingiberis 30, Cortex Cinnamomi 30, Pericarpium Citri Reticulatae 50, the Radix Aucklandiae 25, Radix Glycyrrhizae 25, Radix Codonopsis 60, Pseudobulbus Bletillae (Rhizoma Bletillae) 80, Endoconcha Sepiae 80 and Semen Armeniacae Amarum 20.
4. the Chinese medicine composition according to any one of claim 1-3, is characterized in that, described Chinese medicine composition is capsule, tablet, powder, pill, decoction, mixture or granule.
5. prepare the method for Chinese medicine composition described in any one of claim 1-4, it is characterized in that, comprise the following steps:
1) Radix Salviae Miltiorrhizae, Endoconcha Sepiae and the Radix Aucklandiae are worn into coarse powder, then by coarse powder and Rhizoma Corydalis, Cortex Cinnamomi alcohol reflux, filter, decompression filtrate recycling ethanol, obtains ethanol concentrated solution;
2), after Semen Armeniacae Amarum being smashed to pieces, soak together with Pseudobulbus Bletillae (Rhizoma Bletillae) with Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Radix Codonopsis; By the medical material after soaking and step 1) in medical material water extraction after alcohol reflux, filter, concentrated filtrate, obtains filtrate concentrated solution; The volatile oil obtained in water extraction process collected by another device simultaneously;
3) above-mentioned ethanol concentrated solution and filtrate concentrated solution are merged, be condensed into thick paste;
4) volatile oil and thick paste are merged, to obtain final product.
6. method according to claim 5, is characterized in that, step 1) in the concrete grammar of alcohol reflux be: the concentration adding 8-12 times of medical material weight is the ethanol of 70%-90%, heating and refluxing extraction 1h-4h, filters, decompression filtrate recycling ethanol.
7. method according to claim 5, is characterized in that, step 2) in medical material is soaked 8-24h before water extraction, the method for water extraction is specially: with water extraction 2-3 time, add the water of 6-12 times of medical material weight, each decocting time is 1-3h at every turn; After decoction, filter, merging filtrate, be evaporated to appropriate.
8. method according to claim 7, is characterized in that, step 2) in the method for water extraction be specially: extracting in water 3 times, adds the soak by water 1.5h of 10 times of medical material weight for the 1st time, adds the soak by water 1h of 8 times of medical material weight for the 2nd time and the 3rd time respectively.
9. the application in Chinese medicine composition described in any one of claim 1-4 in the medicine for the preparation for the treatment of peptic ulcer, described peptic ulcer refers to gastric duodenal ulcer, esophageal peptic ulcer, ileum far-end peptic ulcer.
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