CN105168794A - Pharmaceutical composition and preparation method, preparations and application thereof - Google Patents
Pharmaceutical composition and preparation method, preparations and application thereof Download PDFInfo
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- CN105168794A CN105168794A CN201510735470.7A CN201510735470A CN105168794A CN 105168794 A CN105168794 A CN 105168794A CN 201510735470 A CN201510735470 A CN 201510735470A CN 105168794 A CN105168794 A CN 105168794A
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Abstract
The invention discloses a pharmaceutical composition and a preparation method, preparations and an application thereof. The pharmaceutical composition comprises the following herbal materials in parts by weight: 40-60 parts of rhizoma paridis, 40-60 parts of radix pseudostellariae and/or codonopsis pilosula, 70-90 parts of yam, 40-60 parts of malaytea scurfpea fruits, and 50-60 parts of cuttlebone; and the pharmaceutical composition is prepared through the steps of pretreatment, extraction, uniform mixing, drying, crushing and sieving. The preparation method comprises the steps of pretreatment, extraction, uniform mixing, drying, crushing and sieving. The application refers to that the pharmaceutical composition is applied to the preparation of medicaments for treating gastrointestinal diseases, wherein the gastrointestinal diseases include gastric ulcer, duodenal bulbar ulcer, chronic superficial gastritis, atrophic gastritis, colitis, ulcerative colitis or non-characteristic colitis. The pharmaceutical composition has the characteristics of safe and reliable curative effect and low toxic and side effects.
Description
Technical field
The invention belongs to Chinese drug preparation technique field, be specifically related to a kind of pharmaceutical composition and preparation method thereof, preparation and application.
Background technology
Gastrointestinal tract is the maximum immune organ of human body, is also the maximum toxin expelling organ of human body.Gastrointestinal tract refers to the digestive tube from stomach pylorus to anus.Intestinal is one section the longest in digestive tube, is also most important one section of function.The gastric mucosa acute inflammation that acute gastritis system is caused by different pathogeny.Pathological changes severe patient can involve tela submucosa and muscle layer, even deeply reaches placenta percreta.Press the difference of the cause of disease and pathological change clinically, be divided into
acute simple gastritis,
acute erosive gastritis,
acute corrosive gastritis,
acute phlegmonous gastritis, wherein common with acute simple gastritis clinically, and due to antibiotic extensive use, acute phlegmonous gastritis is rare.Cause the factor of morbidity a lot, have the stimulation of chemistry or physics, also have antibacterial or its toxin to cause.Chemical stimulation mainly from spirits, strong tea, coffee, spice and medicine (as salicylate preparations, indometacin, Phenylbutazone,
glucocorticoiddeng), wherein acute corrosive
gastritismostly be caused by strong acid of swallowing, highly basic and other caustic.Physical stimulation, as overheated, supercool, too coarse food and roentgen radiation x, all can damage gastric mucosa, cause inflammation and sexually revise.And the food of take food antibacterial or its endotoxin contamination, be cause the modal cause of disease of acute gastritis.Symptom is that the lighter only has stomachache, Nausea and vomiting, dyspepsia; Severe patient can have hematemesis, melena, even dehydration and poisoning and shock etc.Chronic gastritis means the various chronic gastric mucosal inflammatory pathological changes that different pathogeny causes, and be a kind of commonly encountered diseases, one of Ye Shi army frequently-occurring disease, its sickness rate is various
gastropathyin rank first.Since fiberendoscope extensive use, primary disease understanding is significantly improved.Chronic gastritis often has atrophy (mucosa loss of function) to a certain degree and changes raw, often involves cardia, reduces with G cell loss and gastrin secretion, also body of stomach can be involved, with the forfeiture of secreting acid gland, cause gastric acid, the minimizing of pepsin and endogenous factors.Chronic gastritis lacks specific symptom, and the weight of symptom and the lesion degree of gastric mucosa are also non-uniform.Most patient often asymptomatic or have degree different indigestion symptom as upper abdomen dull pain, loss of appetite, post-prandial fullness, acid regurgitation etc.Patients with atrophic gastritis can have that anemia, water are thin, glossitis, diarrhoea etc., and individuals patients accompanies mucosal erosion person's upper abdominal pain comparatively obvious, and can have hemorrhage.Upper abdominal pain, dyspepsia, hematemesis, melena.Usually symptom is recurrent exerbation, and irregularities stomachache, pain often to come across in feeding process or after the meal and majority is positioned at epigastrium, umbilicus week, part infant ministries and commissions are not fixed, light intermittent dull pain or bluntly to push away, severe patient is violent angor.Often with
inappetence, Nausea and vomiting,
abdominal distention, continue to affect nutriture and growth promoter.Gastric mucosal erosive haemorrhage person accompanies hematemesis, melena.Ulcerative colitis is that one is confined to mucous membrane of colon and submucosal inflammatory process.The sick multidigit that obtains, in sigmoid colon and rectum, also may extend to descending colon, even whole colon.Pathology is very long, normal recurrent exerbation.Primary disease sees any, but 20-30 year is the most common.
Clinical medicine symptom: (one) mucous membrane of colon of getting involved presents superficial ulcer, with congested, edema; Pathological changes is how initial by rectum, often involves colon, distributes in diffusivity.(2) the coarse injustice of intestinal mucosa outward appearance, presents fine particulate, organizes fragility to be easy to hemorrhage, maybe can be coated with dense sexual secretion, like one deck
thin coatingattachment.(3) haustra of colon often flattens or rust, so that knob bag disappears, sometimes can see multiple pseudopolyp differed in size.(4) change of mucous membrane of colon biopsy pathology presents inflammatory reaction, and with often arriving mucosal erosion as seen, crypt abscess, colon body of gland arrangement exception and epithelium change.
At present, the medicine of market being treated gastrointestinal tract class disease is numerous, but all exists and fundamentally can not solve this type of disease and also can bring more larger toxic and side effects simultaneously.Therefore, develop the little and eutherapeutic gastroenteropathy medicine of a kind of toxic and side effects to be very important.
Summary of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition; Second object is to provide the preparation method of described pharmaceutical composition; 3rd object is to provide the preparation of described pharmaceutical composition; 4th object is to provide the application of described pharmaceutical composition.
The first object of the present invention realizes like this, described pharmaceutical composition comprises raw material medicines in portions by weight Rhizoma Paridis 40 ~ 60 parts, Radix Pseudostellariae and/or Radix Codonopsis 40 ~ 60 parts, Rhizoma Dioscoreae 70 ~ 90 parts, Fructus Psoraleae 40 ~ 60 parts, dry through pre-treatment, extraction, mixing, pulverize and sieve after prepare.
The second object of the present invention is achieved in that and comprises pre-treatment, extraction, mixing drying, the step that pulverizes and sieves, and specifically comprises:
A, pre-treatment: weigh respectively by crude drug composition and ratio, by crude drug Radix Pseudostellariae and/or Radix Codonopsis, that Radix Notoginseng pulverized 60 ~ 70 mesh sieves was respectively for subsequent use;
B, extraction: by other crude drug except Radix Pseudostellariae and/or Radix Salviae Miltiorrhizae, Radix Notoginseng by extracting, filtering, concentrated obtain relative density be 1.1 ~ 1.5 extractum for subsequent use;
C, mixing are dry: by the medicated powder mixing of the extractum that extracts and pre-treatment, and being dried to moisture content is 2 ~ 8% obtain target first product;
D, to pulverize and sieve: object first product was pulverized 60 ~ 70 mesh sieves and obtains object.
The third object of the present invention is achieved in that in described pharmaceutical composition that adding the adjuvant pharmaceutically accepted is prepared into powder, tablet, capsule, granule, drop pill or honey pill agent.
The fourth object of the present invention realizes like this, the application of described pharmaceutical composition in preparation treatment gastrointestinal class disease medicament, described stomach intestinal disease is gastric ulcer, duodenal bulbar ulcer, chronic superficial gastritis, atrophic gastritis, colitis, ulcerative colitis or non-characteristic colitis.
In medicament composing prescription of the present invention, Radix Pseudostellariae and/or Radix Codonopsis, Fructus Psoraleae, Rhizoma Paridis, Rhizoma Dioscoreae, Endoconcha Sepiae, benefiting qi and nourishing blood, spleen benefiting and stimulating the appetite, be all monarch drug; Rhizoma Corydalis, Cortex Cinnamomi, Radix Notoginseng, Fructus Amomi, Rhizoma Zingiberis warming the spleen stomach, warm Liver and kidney, cold relieving, dissipating blood stasis for subsidence of swelling, warming middle-JIAO to relieve pain, be all ministerial drug; Radix Salviae Miltiorrhizae and/or Fructus Evodiae, Olibanum, Myrrha, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Picrorhizae nourishing blood and promoting blood circulation, be all adjuvant drug; Flos Caryophylli and/or the Radix Aucklandiae, Rhizoma Cyperi, Rhizoma Atractylodis, Bulbus Fritillariae Thunbergii and/or Bulbus Fritillariae Cirrhosae, the astringent or styptic treatment for spontaneous sweating convergence of Fructus Schisandrae Chinensis, follow gas pain relieving, strengthening the spleen and stomach is all and makes medicine.We prove after deliberation, have the features such as curative effect is safe and reliable, toxic and side effects is low.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, but limited the present invention never in any form, and any conversion done based on training centre of the present invention or replacement, all belong to protection scope of the present invention.
Pharmaceutical composition of the present invention, comprise raw material medicines in portions by weight Rhizoma Paridis 40 ~ 60 parts, Radix Pseudostellariae and/or Radix Codonopsis 40 ~ 60 parts, Rhizoma Dioscoreae 70 ~ 90 parts, Fructus Psoraleae 40 ~ 60 parts, Endoconcha Sepiae 50 ~ 60 parts, dry through pre-treatment, extraction, mixing, pulverize and sieve after prepare.
Described crude drug also comprises weight portion Rhizoma Corydalis 50 ~ 60 parts, Cortex Cinnamomi 60 ~ 80 parts, Radix Notoginseng 30 ~ 40 parts, Fructus Amomi 30 ~ 40 parts, Rhizoma Zingiberis 50 ~ 60 parts.
Described crude drug also comprises the weight portion Pseudobulbus Bletillae (Rhizoma Bletillae) 80 ~ 90 parts, Radix Salviae Miltiorrhizae and/or Fructus Evodiae 30 ~ 40 parts, Rhizoma Picrorhizae 30 ~ 40 parts, Olibanum 30 ~ 40 parts, Myrrha 30 ~ 40 parts.
Described crude drug also comprises weight portion Flos Caryophylli and/or the Radix Aucklandiae 30 ~ 40 parts, Bulbus Fritillariae Thunbergii and/or Bulbus Fritillariae Cirrhosae 50 ~ 60 parts, Rhizoma Atractylodis 50 ~ 60 parts, Fructus Schisandrae Chinensis 40 ~ 50 parts, Rhizoma Cyperi 50 ~ 60 parts.
Described crude drug comprises weight portion Rhizoma Paridis 40 ~ 60 parts, Radix Pseudostellariae and/or Radix Codonopsis 40 ~ 60 parts, Rhizoma Dioscoreae 70 ~ 90 parts, Fructus Psoraleae 40 ~ 60 parts, Endoconcha Sepiae 50 ~ 60 parts, Rhizoma Corydalis 50 ~ 60 parts, Cortex Cinnamomi 60 ~ 80 parts, Radix Notoginseng 30 ~ 40 parts, Fructus Amomi 30 ~ 40 parts, Rhizoma Zingiberis 50 ~ 60 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 80 ~ 90 parts, Radix Salviae Miltiorrhizae and/or Fructus Evodiae 30 ~ 40 parts, Rhizoma Picrorhizae 30 ~ 40 parts, Olibanum 30 ~ 40 parts, Myrrha 30 ~ 40 parts, Flos Caryophylli and/or the Radix Aucklandiae 30 ~ 40 parts, Bulbus Fritillariae Thunbergii and/or Bulbus Fritillariae Cirrhosae 50 ~ 60 parts, Rhizoma Atractylodis 50 ~ 60 parts, Fructus Schisandrae Chinensis 40 ~ 50 parts and Rhizoma Cyperi 50 ~ 60 parts.
The preparation method of pharmaceutical composition of the present invention, comprises pre-treatment, extraction, mixing drying, the step that pulverizes and sieves, specifically comprises:
A, pre-treatment: weigh respectively by crude drug composition and ratio, by crude drug Radix Pseudostellariae and/or Radix Codonopsis, that Radix Notoginseng pulverized 60 ~ 70 mesh sieves was respectively for subsequent use;
B, extraction: by other crude drug except Radix Pseudostellariae and/or Radix Salviae Miltiorrhizae, Radix Notoginseng by extracting, filtering, concentrated obtain relative density be 1.1 ~ 1.5 extractum for subsequent use;
C, mixing are dry: by the medicated powder mixing of the extractum that extracts and pre-treatment, and being dried to moisture content is 2 ~ 8% obtain target first product;
D, to pulverize and sieve: object first product was pulverized 60 ~ 70 mesh sieves and obtains object.
The one be extracted as in decocting method, infusion process or percolation described in step B.
Described is extracted as decocting method, and the water namely adding other crude drug weight ratios 4 ~ 10 times except Radix Pseudostellariae and/or Radix Salviae Miltiorrhizae, Radix Notoginseng extracts 2 ~ 4 times in 90 ~ 100 DEG C, and extraction time is each 3 ~ 5h.
The preparation of pharmaceutical composition of the present invention is add the adjuvant pharmaceutically accepted in described pharmaceutical composition to be prepared into powder, tablet, capsule, granule, drop pill or honey pill agent.
Of the present inventionly be applied as the application of described pharmaceutical composition in preparation treatment gastrointestinal class disease medicament, described stomach intestinal disease is gastric ulcer, duodenal bulbar ulcer, chronic superficial gastritis, atrophic gastritis, colitis, ulcerative colitis or non-characteristic colitis.
Embodiment 1
Prepare Rhizoma Paridis 40g, Radix Pseudostellariae 30g, Radix Codonopsis 20g, Rhizoma Dioscoreae 70g, Fructus Psoraleae 40g, Endoconcha Sepiae 50g, Radix Pseudostellariae 30g and Radix Codonopsis 20g was pulverized 60 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 40g, Rhizoma Dioscoreae 70g, Fructus Psoraleae 40g and Endoconcha Sepiae 50g are moved into the 90 DEG C of Hot water immersion 48h adding weight ratio 4 times in extraction pot, with 90 DEG C of hot water with the speed percolation of 2ml/min, collect liquid of filtering, be condensed into the extractum of relative density 1.1 ~ 1.2; By extractum and medicated powder mixing and stirring, being dried to moisture content is 8%, carries out pulverizing 60 mesh sieves and obtains drug target compositions.
Embodiment 2
Prepare Rhizoma Paridis 60g, Radix Pseudostellariae 60g, Rhizoma Dioscoreae 90g, Fructus Psoraleae 60g, Endoconcha Sepiae 60g, Radix Pseudostellariae 60g was pulverized 70 mesh sieves and obtains medicated powder; Remaining Rhizoma Paridis 60g, Rhizoma Dioscoreae 90g, Fructus Psoraleae 60g and Endoconcha Sepiae 60g are moved in extraction pot the 100 DEG C of hot water boiling and extraction 4 times adding weight ratio 10 times, each 5h, filters again, and merging filtrate is also condensed into the extractum of relative density 1.4 ~ 1.5; By extractum and medicated powder mixing and stirring, being dried to moisture content is 2%, carries out pulverizing 70 mesh sieves and obtains drug target compositions.
Embodiment 3
Prepare Rhizoma Paridis 50g, Radix Codonopsis 40g, Rhizoma Dioscoreae 80g, Fructus Psoraleae 50g, Endoconcha Sepiae 55g, Radix Codonopsis 40g was pulverized 65 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 80g, Fructus Psoraleae 50g and Endoconcha Sepiae 55g are moved into the 95 DEG C of Hot water immersion 24h adding weight ratio 8 times in extraction pot, with 95 DEG C of hot water with the speed percolation of 3ml/min, collect liquid of filtering, be condensed into the extractum of relative density 1.3 ~ 1.4; By extractum and medicated powder mixing and stirring, being dried to moisture content is 6%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 4
Prepare Rhizoma Paridis 50g, Radix Pseudostellariae 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Radix Pseudostellariae 50g was pulverized 65 mesh sieves and obtains medicated powder; Remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g are moved in extraction pot the 100 DEG C of hot water boiling and extraction 3 times adding weight ratio 10 times, each 3h, filters again, and merging filtrate is also condensed into the extractum of relative density 1.2 ~ 1.3; By extractum and medicated powder mixing and stirring, being dried to moisture content is 5%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 5
Prepare Rhizoma Paridis 40g, Radix Pseudostellariae 30g, Radix Codonopsis 20g, Rhizoma Dioscoreae 70g, Fructus Psoraleae 40g, Endoconcha Sepiae 50g, Rhizoma Corydalis 50g, Cortex Cinnamomi 60g, Radix Notoginseng 30g, Fructus Amomi 30g, Rhizoma Zingiberis 50g, Radix Pseudostellariae 30g and Radix Codonopsis 20g, Radix Notoginseng 30g were pulverized 60 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 40g, Rhizoma Dioscoreae 70g, Fructus Psoraleae 40g, Endoconcha Sepiae 50g, Rhizoma Corydalis 50g, Cortex Cinnamomi 60g, Fructus Amomi 30g and Rhizoma Zingiberis 50g are moved into the 90 DEG C of Hot water immersion 48h adding weight ratio 4 times in extraction pot, with 90 DEG C of hot water with the speed percolation of 2ml/min, collection is filtered liquid, is condensed into the extractum of relative density 1.1 ~ 1.2; By extractum and medicated powder mixing and stirring, being dried to moisture content is 8%, carries out pulverizing 60 mesh sieves and obtains drug target compositions.
Embodiment 6
Prepare Rhizoma Paridis 60g, Radix Pseudostellariae 60g, Rhizoma Dioscoreae 90g, Fructus Psoraleae 60g, Endoconcha Sepiae 60g, Rhizoma Corydalis 60g, Cortex Cinnamomi 80g, Radix Notoginseng 40g, Fructus Amomi 40g, Rhizoma Zingiberis 60g, Radix Pseudostellariae 60g, Radix Notoginseng 40g were pulverized 70 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 60g, Rhizoma Dioscoreae 90g, Fructus Psoraleae 60g, Endoconcha Sepiae 60g, Rhizoma Corydalis 60g, Cortex Cinnamomi 80g, Radix Notoginseng 40g, Fructus Amomi 40g and Rhizoma Zingiberis 60g are moved in extraction pot the 100 DEG C of hot water boiling and extraction 4 times adding weight ratio 10 times, each 5h, filter, merging filtrate is also condensed into the extractum of relative density 1.4 ~ 1.5; By extractum and medicated powder mixing and stirring, being dried to moisture content is 2%, carries out pulverizing 70 mesh sieves and obtains drug target compositions.
Embodiment 7
Prepare Rhizoma Paridis 50g, Radix Codonopsis 40g, Rhizoma Dioscoreae 80g, Fructus Psoraleae 50g, Endoconcha Sepiae 55g, Rhizoma Corydalis 55g, Cortex Cinnamomi 70g, Radix Notoginseng 35g, Fructus Amomi 35g, Rhizoma Zingiberis 55g, Radix Codonopsis 40g, Radix Notoginseng 35g were pulverized 65 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 80g, Fructus Psoraleae 50g, Endoconcha Sepiae 55g, Rhizoma Corydalis 55g, Cortex Cinnamomi 70g, Fructus Amomi 35g and Rhizoma Zingiberis 55g are moved into the 95 DEG C of Hot water immersion 24h adding weight ratio 8 times in extraction pot, with 95 DEG C of hot water with the speed percolation of 3ml/min, collection is filtered liquid, is condensed into the extractum of relative density 1.3 ~ 1.4; By extractum and medicated powder mixing and stirring, being dried to moisture content is 6%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 8
Prepare Rhizoma Paridis 50g, Radix Pseudostellariae 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Rhizoma Corydalis 55g, Cortex Cinnamomi 69g, Radix Notoginseng 35g, Fructus Amomi 35g, Rhizoma Zingiberis 52g, Radix Pseudostellariae 50g, Radix Notoginseng 35g were pulverized 65 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Rhizoma Corydalis 55g, Cortex Cinnamomi 69g, Fructus Amomi 35g and Rhizoma Zingiberis 52g are moved in extraction pot the 100 DEG C of hot water boiling and extraction 3 times adding weight ratio 10 times, each 3h, filter, merging filtrate is also condensed into the extractum of relative density 1.2 ~ 1.3; By extractum and medicated powder mixing and stirring, being dried to moisture content is 5%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 9
Prepare Rhizoma Paridis 40g, Radix Pseudostellariae 30g, Radix Codonopsis 20g, Rhizoma Dioscoreae 70g, Fructus Psoraleae 40g, Endoconcha Sepiae 50g, Pseudobulbus Bletillae (Rhizoma Bletillae) 80g, Radix Salviae Miltiorrhizae 30g, Fructus Evodiae 10g, Rhizoma Picrorhizae 30g, Olibanum 30g, Myrrha 30g, Radix Pseudostellariae 30g and Radix Codonopsis 20g was pulverized 60 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 40g, Rhizoma Dioscoreae 70g, Fructus Psoraleae 40g, Endoconcha Sepiae 50g, Pseudobulbus Bletillae (Rhizoma Bletillae) 80g, Radix Salviae Miltiorrhizae 30g, Fructus Evodiae 10g, Rhizoma Picrorhizae 30g, Olibanum 30g and Myrrha 30g are moved into the 90 DEG C of Hot water immersion 48h adding weight ratio 4 times in extraction pot, with 90 DEG C of hot water with the speed percolation of 2ml/min, collection is filtered liquid, is condensed into the extractum of relative density 1.1 ~ 1.2; By extractum and medicated powder mixing and stirring, being dried to moisture content is 8%, carries out pulverizing 60 mesh sieves and obtains drug target compositions.
Embodiment 10
Prepare Rhizoma Paridis 60g, Radix Pseudostellariae 60g, Rhizoma Dioscoreae 90g, Fructus Psoraleae 60g, Endoconcha Sepiae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90g, Radix Salviae Miltiorrhizae 40g, Rhizoma Picrorhizae 40g, Olibanum 40g, Myrrha 40g, Radix Pseudostellariae 60g was pulverized 70 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 60g, Rhizoma Dioscoreae 90g, Fructus Psoraleae 60g, Endoconcha Sepiae 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90g, Radix Salviae Miltiorrhizae 40g, Rhizoma Picrorhizae 40g, Olibanum 40g and Myrrha 40g are moved in extraction pot the 100 DEG C of hot water boiling and extraction 4 times adding weight ratio 10 times, each 5h, filter, merging filtrate is also condensed into the extractum of relative density 1.4 ~ 1.5; By extractum and medicated powder mixing and stirring, being dried to moisture content is 2%, carries out pulverizing 70 mesh sieves and obtains drug target compositions.
Embodiment 11
Prepare Rhizoma Paridis 50g, Radix Codonopsis 40g, Rhizoma Dioscoreae 80g, Fructus Psoraleae 50g, Endoconcha Sepiae 55g, Pseudobulbus Bletillae (Rhizoma Bletillae) 85g, Fructus Evodiae 30g, Rhizoma Picrorhizae 35g, Olibanum 35g, Myrrha 35g, Radix Codonopsis 40g was pulverized 65 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 80g, Fructus Psoraleae 50g, Endoconcha Sepiae 55g, Pseudobulbus Bletillae (Rhizoma Bletillae) 85g, Fructus Evodiae 30g, Rhizoma Picrorhizae 35g, Olibanum 35g and Myrrha 35g are moved into the 95 DEG C of Hot water immersion 24h adding weight ratio 8 times in extraction pot, with 95 DEG C of hot water with the speed percolation of 3ml/min, collection is filtered liquid, is condensed into the extractum of relative density 1.3 ~ 1.4; By extractum and medicated powder mixing and stirring, being dried to moisture content is 6%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 12
Prepare Rhizoma Paridis 50g, Radix Pseudostellariae 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Pseudobulbus Bletillae (Rhizoma Bletillae) 82g, Fructus Evodiae 37g, Rhizoma Picrorhizae 32g, Olibanum 35g, Myrrha 33g, Radix Pseudostellariae 50g was pulverized 65 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Pseudobulbus Bletillae (Rhizoma Bletillae) 82g, Fructus Evodiae 37g, Rhizoma Picrorhizae 32g, Olibanum 35g and Myrrha 33g are moved in extraction pot the 100 DEG C of hot water boiling and extraction 3 times adding weight ratio 10 times, each 3h, filter, merging filtrate is also condensed into the extractum of relative density 1.2 ~ 1.3; By extractum and medicated powder mixing and stirring, being dried to moisture content is 5%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 13
Prepare Rhizoma Paridis 50g, Radix Pseudostellariae 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Rhizoma Corydalis 55g, Cortex Cinnamomi 69g, Radix Notoginseng 35g, Fructus Amomi 35g, Rhizoma Zingiberis 52g, pulverized 65 mesh sieves by Radix Pseudostellariae 50g, Radix Notoginseng 35g and obtained medicated powder; Again remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Rhizoma Corydalis 55g, Cortex Cinnamomi 69g, Fructus Amomi 35g and Rhizoma Zingiberis 52g are moved in extraction pot the 100 DEG C of hot water boiling and extraction 3 times adding weight ratio 10 times, each 3h, filter, merging filtrate is also condensed into the extractum of relative density 1.2 ~ 1.3; By extractum and medicated powder mixing and stirring, being dried to moisture content is 5%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 14
Prepare Rhizoma Paridis 40g, Radix Pseudostellariae 30g, Radix Codonopsis 20g, Rhizoma Dioscoreae 70g, Fructus Psoraleae 40g, Endoconcha Sepiae 50g, Rhizoma Corydalis 50g, Cortex Cinnamomi 60g, Radix Notoginseng 30g, Fructus Amomi 30g, Rhizoma Zingiberis 50g, Pseudobulbus Bletillae (Rhizoma Bletillae) 80g, Radix Salviae Miltiorrhizae 30g, Fructus Evodiae 10g, Rhizoma Picrorhizae 30g, Olibanum 30g, Myrrha 30g, Radix Pseudostellariae 30g and Radix Codonopsis 20g, Radix Notoginseng 30g were pulverized 60 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 40g, Rhizoma Dioscoreae 70g, Fructus Psoraleae 40g, Endoconcha Sepiae 50g, Rhizoma Corydalis 50g, Cortex Cinnamomi 60g, Fructus Amomi 30g, Rhizoma Zingiberis 50g, Pseudobulbus Bletillae (Rhizoma Bletillae) 80g, Radix Salviae Miltiorrhizae 30g, Fructus Evodiae 10g, Rhizoma Picrorhizae 30g, Olibanum 30g and Myrrha 30g are moved into the 90 DEG C of Hot water immersion 48h adding weight ratio 4 times in extraction pot, with 90 DEG C of hot water with the speed percolation of 2ml/min, collection is filtered liquid, is condensed into the extractum of relative density 1.1 ~ 1.2; By extractum and medicated powder mixing and stirring, being dried to moisture content is 8%, carries out pulverizing 60 mesh sieves and obtains drug target compositions.
Embodiment 15
Prepare Rhizoma Paridis 60g, Radix Pseudostellariae 60g, Rhizoma Dioscoreae 90g, Fructus Psoraleae 60g, Endoconcha Sepiae 60g, Rhizoma Corydalis 60g, Cortex Cinnamomi 80g, Radix Notoginseng 40g, Fructus Amomi 40g, Rhizoma Zingiberis 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90g, Radix Salviae Miltiorrhizae 40g, Rhizoma Picrorhizae 40g, Olibanum 40g, Myrrha 40g, Radix Pseudostellariae 60g, Radix Notoginseng 40g were pulverized 70 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 60g, Rhizoma Dioscoreae 90g, Fructus Psoraleae 60g, Endoconcha Sepiae 60g, Rhizoma Corydalis 60g, Cortex Cinnamomi 80g, Fructus Amomi 40g, Rhizoma Zingiberis 60g, Pseudobulbus Bletillae (Rhizoma Bletillae) 90g, Radix Salviae Miltiorrhizae 40g, Rhizoma Picrorhizae 40g, Olibanum 40g and Myrrha 40g are moved in extraction pot the 100 DEG C of hot water boiling and extraction 4 times adding weight ratio 10 times, each 5h, filter, merging filtrate is also condensed into the extractum of relative density 1.4 ~ 1.5; By extractum and medicated powder mixing and stirring, being dried to moisture content is 2%, carries out pulverizing 70 mesh sieves and obtains drug target compositions.
Embodiment 16
Prepare Rhizoma Paridis 50g, Radix Codonopsis 40g, Rhizoma Dioscoreae 80g, Fructus Psoraleae 50g, Endoconcha Sepiae 55g, Rhizoma Corydalis 55g, Cortex Cinnamomi 70g, Radix Notoginseng 35g, Fructus Amomi 35g, Rhizoma Zingiberis 55g, Pseudobulbus Bletillae (Rhizoma Bletillae) 85g, Fructus Evodiae 30g, Rhizoma Picrorhizae 35g, Olibanum 35g, Myrrha 35g, Radix Codonopsis 40g, Radix Notoginseng 35g were pulverized 65 mesh sieves and obtains medicated powder; Again remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 80g, Fructus Psoraleae 50g, Endoconcha Sepiae 55g, Rhizoma Corydalis 55g, Cortex Cinnamomi 70g, Fructus Amomi 35g, Rhizoma Zingiberis 55g, Pseudobulbus Bletillae (Rhizoma Bletillae) 85g, Fructus Evodiae 30g, Rhizoma Picrorhizae 35g, Olibanum 35g and Myrrha 35g are moved into the 95 DEG C of Hot water immersion 24h adding weight ratio 8 times in extraction pot, with 95 DEG C of hot water with the speed percolation of 3ml/min, collection is filtered liquid, is condensed into the extractum of relative density 1.3 ~ 1.4; By extractum and medicated powder mixing and stirring, being dried to moisture content is 6%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 17
Prepare Rhizoma Paridis 50g, Radix Pseudostellariae 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Rhizoma Corydalis 55g, Cortex Cinnamomi 69g, Radix Notoginseng 35g, Fructus Amomi 35g, Rhizoma Zingiberis 52g, Pseudobulbus Bletillae (Rhizoma Bletillae) 82g, Fructus Evodiae 37g, Rhizoma Picrorhizae 32g, Olibanum 35g, Myrrha 33g, Radix Pseudostellariae 50g, Radix Notoginseng 35g were pulverized 65 mesh sieves and obtains medicated powder; Again by remaining Rhizoma Paridis 50g, Rhizoma Dioscoreae 75g, Fructus Psoraleae 55g, Endoconcha Sepiae 54g, Rhizoma Corydalis 55g, Cortex Cinnamomi 69g, Fructus Amomi 35g, Rhizoma Zingiberis 52g, Pseudobulbus Bletillae (Rhizoma Bletillae) 82g, Fructus Evodiae 37g, Rhizoma Picrorhizae 32g, Olibanum 35g and Myrrha 33g move in extraction pot the 100 DEG C of hot water boiling and extraction 3 times adding weight ratio 10 times, each 3h, filter, merging filtrate is also condensed into the extractum of relative density 1.2 ~ 1.3; By extractum and medicated powder mixing and stirring, being dried to moisture content is 5%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 18
Prepare Rhizoma Paridis 53g, Radix Pseudostellariae 52g, Rhizoma Dioscoreae 86g, Fructus Psoraleae 52g, Endoconcha Sepiae 52g, Rhizoma Corydalis 55g, Cortex Cinnamomi 69g, Radix Notoginseng 35g, Fructus Amomi 35g, Rhizoma Zingiberis 52g, Pseudobulbus Bletillae (Rhizoma Bletillae) 83g, Radix Salviae Miltiorrhizae 36g, Rhizoma Picrorhizae 35g, Olibanum 35g, Myrrha 35g, Radix Pseudostellariae 52g, Radix Notoginseng 35g were pulverized 65 mesh sieves and obtains medicated powder; Again by remaining Rhizoma Paridis 53g, Rhizoma Dioscoreae 86g, Fructus Psoraleae 52g, Endoconcha Sepiae 52g, Rhizoma Corydalis 55g, Cortex Cinnamomi 69g, Fructus Amomi 35g, Rhizoma Zingiberis 52g, Pseudobulbus Bletillae (Rhizoma Bletillae) 83g, Radix Salviae Miltiorrhizae 36g, Rhizoma Picrorhizae 35g, Olibanum 35g and Myrrha 35g move in extraction pot the 100 DEG C of hot water boiling and extraction 3 times adding weight ratio 10 times, each 4h, filter, merging filtrate is also condensed into the extractum of relative density 1.2 ~ 1.3; By extractum and medicated powder mixing and stirring, being dried to moisture content is 8%, carries out pulverizing 65 mesh sieves and obtains drug target compositions.
Embodiment 19
Pharmaceutical composition pack prepared by Example 1 becomes powder.
Embodiment 20
Pharmaceutical composition prepared by Example 15 adds pharmaceutically acceptable adjuvant and makes tablet.
Embodiment 21
Pharmaceutical composition prepared by Example 18 adds pharmaceutically acceptable adjuvant and makes capsule.
Embodiment 22
Pharmaceutical composition prepared by Example 3 adds pharmaceutically acceptable adjuvant and makes granule.
Embodiment 23
Pharmaceutical composition prepared by Example 12 adds pharmaceutically acceptable adjuvant and makes drop pill.
Embodiment 24
Pharmaceutical composition prepared by Example 9 adds pharmaceutically acceptable adjuvant and makes honey pill agent.
Embodiment 25
Test with the pharmaceutical composition that embodiment 3 prepares, its result is as follows:
One, toxicity test:
1, experiment material: Kunming mouse, body weight 20.0 ± 2.0g, male and female half and half, are provided by Kunming hospital general Experimental Animal Center.
Sample: the pharmaceutical composition that the present embodiment 3 prepares
Experimental technique: oral administration, every mice presses 10g body weight 0.5ml volume gavage, every day 2 times.
2, experimental result:
| Dosage (g/kg) | Number of animals (n) | Mortality rate |
| 6.75 | 6 | 0 |
| 10.13 | 12 | 0 |
Conclusion: after the pharmaceutical composition oral administration that the present embodiment 3 prepares, dosage 6.75g/kg and 10.13g/kg (maximum tolerated dose), observes one week, and just usually, none is only dead for mouse growth.
Two, the test of pesticide effectiveness:
Minimum 28 years old of patient age, maximum 75 years old, 37 years old mean age, wherein, male 55 example, women 45 example.Patient all has chronic epigastrium pain (abdomen dull pain, causalgia or severe pain) history, in periodical attack, relevant with season, spirit, diet etc.; Normal and have upper gastrointestinal hemorrhage.Physical examination: see direct signs such as having niche and mucosal fold to concentrate through x-ray barium meal examination, gastroscopy can in stomach or (and) pyloric cap, ball rear portion is round, oval or linear, bottom is smooth, with the ulcer of white fur, neat in edge.Visible petechial hemorrhage point in various degree, ulcer surface.Fecal Occult Blood Testing, is positive.
Therapeutic Method, the pharmaceutical composition that half an hour ante cibum, oral administration the present embodiment 3 prepared, be 0.3 ~ 0.6g each serving dose, every day 3 times, period in a medicine avoids pungent, peppery, sour, cold drinks and snachs thing, within one month, is a course for the treatment of.
Therapeutic outcome: through course of therapy, a Quan Yu, 70 example, account for 70%.Cure 15 examples through two courses for the treatment of, account for 15%.Cure 10 examples through three courses for the treatment of, account for 10%, invalid 10 examples, account for 10%.Total effective rate 90%.
Embodiment 26
Prepare pharmaceutical composition with embodiment 1,2,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 respectively to test, test method is identical with embodiment 25, result all show pharmaceutical composition of the present invention to stomach intestinal disease as: gastric ulcer, duodenal bulbar ulcer, chronic superficial gastritis, atrophic gastritis, colitis, ulcerative colitis or non-characteristic colitis have good therapeutic effect.
Claims (10)
1. a pharmaceutical composition, it is characterized in that described pharmaceutical composition comprises raw material medicines in portions by weight Rhizoma Paridis 40 ~ 60 parts, Radix Pseudostellariae and/or Radix Codonopsis 40 ~ 60 parts, Rhizoma Dioscoreae 70 ~ 90 parts, Fructus Psoraleae 40 ~ 60 parts, Endoconcha Sepiae 50 ~ 60 parts, dry through pre-treatment, extraction, mixing, pulverize and sieve after prepare.
2. pharmaceutical composition according to claim 1, is characterized in that described crude drug also comprises weight portion Rhizoma Corydalis 50 ~ 60 parts, Cortex Cinnamomi 60 ~ 80 parts, Radix Notoginseng 30 ~ 40 parts, Fructus Amomi 30 ~ 40 parts, Rhizoma Zingiberis 50 ~ 60 parts.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that described crude drug also comprises the weight portion Pseudobulbus Bletillae (Rhizoma Bletillae) 80 ~ 90 parts, Radix Salviae Miltiorrhizae and/or Fructus Evodiae 30 ~ 40 parts, Rhizoma Picrorhizae 30 ~ 40 parts, Olibanum 30 ~ 40 parts, Myrrha 30 ~ 40 parts.
4. pharmaceutical composition according to claim 3, is characterized in that described crude drug also comprises weight portion Flos Caryophylli and/or the Radix Aucklandiae 30 ~ 40 parts, Bulbus Fritillariae Thunbergii and/or Bulbus Fritillariae Cirrhosae 50 ~ 60 parts, Rhizoma Atractylodis 50 ~ 60 parts, Fructus Schisandrae Chinensis 40 ~ 50 parts, Rhizoma Cyperi 50 ~ 60 parts.
5. pharmaceutical composition according to claim 4, it is characterized in that described crude drug comprises weight portion Rhizoma Paridis 40 ~ 60 parts, Radix Pseudostellariae and/or Radix Codonopsis 40 ~ 60 parts, Rhizoma Dioscoreae 70 ~ 90 parts, Fructus Psoraleae 40 ~ 60 parts, Endoconcha Sepiae 50 ~ 60 parts, Rhizoma Corydalis 50 ~ 60 parts, Cortex Cinnamomi 60 ~ 80 parts, Radix Notoginseng 30 ~ 40 parts, Fructus Amomi 30 ~ 40 parts, Rhizoma Zingiberis 50 ~ 60 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 80 ~ 90 parts, Radix Salviae Miltiorrhizae and/or Fructus Evodiae 30 ~ 40 parts, Rhizoma Picrorhizae 30 ~ 40 parts, Olibanum 30 ~ 40 parts, Myrrha 30 ~ 40 parts, Flos Caryophylli and/or the Radix Aucklandiae 30 ~ 40 parts, Bulbus Fritillariae Thunbergii and/or Bulbus Fritillariae Cirrhosae 50 ~ 60 parts, Rhizoma Atractylodis 50 ~ 60 parts, Fructus Schisandrae Chinensis 40 ~ 50 parts and Rhizoma Cyperi 50 ~ 60 parts.
6. a preparation method for the arbitrary described pharmaceutical composition of claim 1 ~ 5, is characterized in that comprising pre-treatment, extraction, mixing drying, the step that pulverizes and sieves, specifically comprises:
A, pre-treatment: weigh respectively by crude drug composition and ratio, by crude drug Radix Pseudostellariae and/or Radix Codonopsis, that Radix Notoginseng pulverized 60 ~ 70 mesh sieves was respectively for subsequent use;
B, extraction: by other crude drug except Radix Pseudostellariae and/or Radix Salviae Miltiorrhizae, Radix Notoginseng by extracting, filtering, concentrated obtain relative density be 1.1 ~ 1.5 extractum for subsequent use;
C, mixing are dry: by the medicated powder mixing of the extractum that extracts and pre-treatment, and being dried to moisture content is 2 ~ 8% obtain target first product;
D, to pulverize and sieve: object first product was pulverized 60 ~ 70 mesh sieves and obtains object.
7. preparation method according to claim 6, is characterized in that the one be extracted as in decocting method, infusion process or percolation described in step B.
8. the preparation method according to claim 6 or 7, it is characterized in that described being extracted as decocting method, namely the water adding other crude drug weight ratios 4 ~ 10 times except Radix Pseudostellariae and/or Radix Salviae Miltiorrhizae, Radix Notoginseng extracts 2 ~ 4 times in 90 ~ 100 DEG C, and extraction time is each 3 ~ 5h.
9. a preparation for the arbitrary described pharmaceutical composition of claim 1 ~ 5, is characterized in that adding the adjuvant pharmaceutically accepted in described pharmaceutical composition is prepared into powder, tablet, capsule, granule, drop pill or honey pill agent.
10. the application of the arbitrary described pharmaceutical composition of claim 1 ~ 5 in preparation treatment gastrointestinal class disease medicament, described stomach intestinal disease is gastric ulcer, duodenal bulbar ulcer, chronic superficial gastritis, atrophic gastritis, colitis, ulcerative colitis or non-characteristic colitis.
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