CN104000969B - A kind of Chinese materia medica preparation for treating children's intestines system lymphonodi abdominales inflammation - Google Patents
A kind of Chinese materia medica preparation for treating children's intestines system lymphonodi abdominales inflammation Download PDFInfo
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- CN104000969B CN104000969B CN201410206332.5A CN201410206332A CN104000969B CN 104000969 B CN104000969 B CN 104000969B CN 201410206332 A CN201410206332 A CN 201410206332A CN 104000969 B CN104000969 B CN 104000969B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 230000003187 abdominal effect Effects 0.000 title claims abstract description 16
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- 206010061218 Inflammation Diseases 0.000 title claims abstract description 15
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 15
- 239000002398 materia medica Substances 0.000 title claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 24
- 240000001519 Verbena officinalis Species 0.000 claims abstract description 13
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 13
- 235000018718 Verbena officinalis Nutrition 0.000 claims abstract description 12
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- 241001116389 Aloe Species 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 235000019441 ethanol Nutrition 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 6
- 229940100688 oral solution Drugs 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 2
- 230000006837 decompression Effects 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims 1
- 208000004998 Abdominal Pain Diseases 0.000 abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 7
- 210000001015 abdomen Anatomy 0.000 abstract description 5
- 238000002604 ultrasonography Methods 0.000 abstract description 5
- 230000036760 body temperature Effects 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 description 7
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- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
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- 239000007788 liquid Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 244000144927 Aloe barbadensis Species 0.000 description 2
- 235000002961 Aloe barbadensis Nutrition 0.000 description 2
- 206010057190 Respiratory tract infections Diseases 0.000 description 2
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
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- 208000010453 mesenteric lymphadenitis Diseases 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 206010000084 Abdominal pain lower Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
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- 244000060924 Brassica campestris Species 0.000 description 1
- 235000005637 Brassica campestris Nutrition 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000009847 Cucumis melo var cantalupensis Nutrition 0.000 description 1
- 240000004244 Cucurbita moschata Species 0.000 description 1
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
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- 229960002727 cefotaxime sodium Drugs 0.000 description 1
- AZZMGZXNTDTSME-JUZDKLSSSA-M cefotaxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 AZZMGZXNTDTSME-JUZDKLSSSA-M 0.000 description 1
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- FDRNWTJTHBSPMW-GNXCPKRQSA-L disodium;(6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound [Na+].[Na+].S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)/C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C([O-])=NN1C FDRNWTJTHBSPMW-GNXCPKRQSA-L 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Chinese materia medica preparation for treating children's intestines system lymphonodi abdominales inflammation, which is prepared by raw material and auxiliary material, and by weight, the raw material includes 2-5 parts of aloe, 30-50 parts of pedicellus cucurbitae, 21-30 parts of Verbena officinalis, 8-16 parts of brassicae chinensis,semen.After Chinese medicine preparation treatment of the invention, the abdominal pain of infant and simultaneous disease disappear, and body temperature is normal, and belly color ultrasound checks lymphonodi mesenterici and restores normal.
Description
Technical field
The invention belongs to technical field of Chinese medicine, treat in children's intestines system lymphonodi abdominales inflammation in particular to a kind of
Medicine preparation.
Background technique
Infantile adenomesenteritis (mesenteric lymphadenitis) is to cause children acute abdominal pain, and feature is
A kind of big common disease of mesenteric adenophyma.It is clinically mostly showed with abdominal pain to be main, or with fever and other digestion
Road symptom.This disease is apt to occur in 8 years old or less children more, after being common in acute upper respiratory infection or intestinal inflammatory.Due to virus or
Bacterium infection and cause mesenteric lymphadenitis disease, the easy mistaken diagnosis of part right lower abdominal pain patient clinical be ecphyaditis.Modern medicine is controlled
It treats and predominantly uses broad-spectrum antibiotic and anti symptom treatment, but the side effects such as antibiotic adverse reaction, drug resistance are big, high recurrence rate.
Summary of the invention
The purpose of the present invention is to provide a kind of pharmaceutical compositions for treating children's intestines system lymphonodi abdominales inflammation.The pharmaceutical composition
Object is to improve and obtain on the basis of secret prescription handed down in the family from generation to generation, has the advantages that treatment is significant, it is low to spend, determines after many decades clinical application
It is a kind of specific medicament for treating children's intestines system lymphonodi abdominales inflammation.
The object of the present invention is achieved like this:
A kind of Chinese materia medica preparation for treating children's intestines system lymphonodi abdominales inflammation, is prepared: reed by the Chinese medicine of following parts by weight
2-5 parts of luxuriant growth, 30-50 parts of pedicellus cucurbitae, 21-30 parts of Verbena officinalis, 8-16 parts of brassicae chinensis,semen.
Preferably, the Chinese materia medica preparation for treating children's intestines system lymphonodi abdominales inflammation as described above, by following parts by weight
Medicinal material is prepared: 3-4 parts of aloe, 35-42 parts of pedicellus cucurbitae, 24-26 parts of Verbena officinalis, 10-14 parts of brassicae chinensis,semen.
In a most preferred embodiment of the invention, the Chinese medicine as described above for treating children's intestines system lymphonodi abdominales inflammation
Preparation is prepared by the Chinese medicine of following parts by weight: 3 parts of aloe, 38 parts of pedicellus cucurbitae, 25 parts of Verbena officinalis, 12 parts of brassicae chinensis,semen.
It is further preferred that the Chinese materia medica preparation for the treatment of children's intestines system lymphonodi abdominales inflammation is oral preparation.
Still further preferably, the Chinese materia medica preparation for the treatment of children's intestines system lymphonodi abdominales inflammation be oral solution, granule,
Tablets and capsules.
It is found by a large amount of clinical application experimental study, pharmaceutical composition being prepared by above-mentioned Chinese medicine is being treated
The scorching aspect of children's intestines system lymphonodi abdominales obtains satisfied curative effect.Therefore, second object of the present invention is to provide a kind of doctor
Medicine new application, i.e., application of the above-mentioned pharmaceutical preparation in the drug of preparation treatment children's intestines system lymphonodi abdominales inflammation.
By the preparation method of the Chinese materia medica preparation of above-mentioned each Chinese medicine preparation cost invention, include the following steps: to weigh cleaning
Clean and drying 2-5 parts of aloe, 30-50 parts of pedicellus cucurbitae, 21-30 parts of Verbena officinalis, 8-16 parts of brassicae chinensis,semen, merge, add water to cook
Twice, collecting decoction, relative density is 1.15-1.20 when being concentrated under reduced pressure into 70 DEG C, and ethyl alcohol is added to make the percent by volume of alcohol content
It up to 75-85%, stirs, stands, filtering, relative density is 1.20-1.30 and recycles ethyl alcohol and obtain when filtrate decompression is concentrated into 70 DEG C
Concentrate.By concentrate plus water and auxiliaries at oral solution, or by concentrate vacuum drying (60 DEG C or less) at dry cream,
It crushes, adds pharmaceutic adjuvant, 40 mesh particle pulvis are made and pack.
For the treatment of children's intestines system lymphonodi abdominales inflammation, though Western medicine controls comparatively fast, to entirety acute stage symptom
Symptom, functional rehabilitation are slower, and abdominal pain is easy recurrent exerbation after treatment, still hinder for interior stagnant unclear, fate.And Chinese medicine can not only make
Symptom is comparatively fast alleviated, and can effect a permanent cure.After Chinese medicine preparation treatment of the invention, the abdominal pain of infant and simultaneous disease disappear, body
Warm normal, belly color ultrasound checks lymphonodi mesenterici and restores normal.In addition, since drug of the invention is by lower using price
Traditional Chinese medicine is prepared, and medical expense is low, has no toxic side effect substantially, and patient medication is safer.
Specific embodiment
The present invention is further illustrated below by embodiment.The embodiment of the present invention is only used for illustrating the present invention, and
It is not limitation of the present invention, the present invention is belonged to the simple modifications of preparation method of the present invention under concept thereof of the invention
Claimed range.
It should be noted that medicinal raw material used by various embodiments of the present invention has following source: aloe selects lily
The dry product of concentrated juice of section's plant aloe barbadensis Miller Aloe barbadensis Miller leaf.Pedicellus cucurbitae selects Curcurbitaceae to plant
The drying muskmelon pedicel of object pumpkin.Verbena officinalis is selected on the dry ground of Verbenaceae Verbena officinalis Verbena officinalis L.
Part.The seed of brassicae chinensis,semen selection Cruciferae Brassica plants rape Brassica campestris L..
The preparation of 1 Chinese herbal granules of embodiment
It weighs aloe 0.03kg, pedicellus cucurbitae 0.38kg, Verbena officinalis 0.25kg, brassicae chinensis,semen 0.12kg to merge, adds water to cook two
Secondary, first time plus water are 10 times of amounts of medicinal material weight, decoct 2h, and for the second time plus water is 8 times of amounts of medicinal material weight, decoct 1.5h,
Collecting decoction, 0.08MPa, relative density is 1.15 when being concentrated under reduced pressure into 70 DEG C at 70 DEG C, and 95% (v/v) ethyl alcohol is added to make alcohol content
Up to 85% (v/v), stirring is stood overnight, and is filtered, and filtrate is opposite when be concentrated under reduced pressure under the conditions of 0.08MPa, 65 DEG C to 65 DEG C
Density is the medicinal extract of 1.25g/mL, and medicinal extract is set in stainless steel disc, and vacuum drying (60 DEG C or less) is crushed at dry cream, adds 2 times of amounts
Cane sugar powder, dry method are made 40 mesh granules and pack, every packet 9g.
The preparation of 2 traditional Chinese medicine oral liquid of embodiment
It weighs aloe 0.03kg, pedicellus cucurbitae 0.45kg, Verbena officinalis 0.30kg, brassicae chinensis,semen 0.16kg to merge, adds water to cook two
Secondary, first time plus water are 10 times of amounts of medicinal material weight, decoct 2h, and for the second time plus water is 8 times of amounts of medicinal material weight, decoct 1.5h,
Collecting decoction, 0.08MPa, relative density is 1.15 when being concentrated under reduced pressure into 70 DEG C at 70 DEG C, and 95% (v/v) ethyl alcohol is added to make alcohol content
Up to 75% (v/v), stirring is stood overnight, and is filtered, and filtrate is opposite when be concentrated under reduced pressure under the conditions of 0.08MPa, 65 DEG C to 65 DEG C
Density is 1.25g/mL, and suitable quantity of water and sucrose is added to be configured to oral solution.
The preparation of 3 traditional Chinese medicine oral liquid of embodiment
It weighs aloe 0.04kg, pedicellus cucurbitae 0.35kg, Verbena officinalis 0.24kg, brassicae chinensis,semen 0.14kg to merge, adds water to cook two
Secondary, first time plus water are 10 times of amounts of medicinal material weight, decoct 2h, and for the second time plus water is 8 times of amounts of medicinal material weight, decoct 1.5h,
Collecting decoction, 0.08MPa, relative density is 1.15 when being concentrated under reduced pressure into 70 DEG C at 70 DEG C, and 95% (v/v) ethyl alcohol is added to make alcohol content
Up to 85% (v/v), stirring is stood overnight, and is filtered, and filtrate is opposite when be concentrated under reduced pressure under the conditions of 0.08MPa, 65 DEG C to 65 DEG C
Density is 1.25g/mL, and suitable quantity of water and sucrose is added to be configured to oral solution.
The preparation of 4 traditional Chinese medicine oral liquid of embodiment
It weighs aloe 0.05kg, pedicellus cucurbitae 0.30kg, Verbena officinalis 0.21kg, brassicae chinensis,semen 0.10kg to merge, adds water to cook two
Secondary, first time plus water are 10 times of amounts of medicinal material weight, decoct 2h, and for the second time plus water is 8 times of amounts of medicinal material weight, decoct 1.5h,
Collecting decoction, 0.08MPa, relative density is 1.20 when being concentrated under reduced pressure into 70 DEG C at 70 DEG C, and 95% (v/v) ethyl alcohol is added to make alcohol content
Up to 80% (v/v), stirring is stood overnight, and is filtered, and filtrate is opposite when be concentrated under reduced pressure under the conditions of 0.08MPa, 65 DEG C to 65 DEG C
Density is 1.25g/mL, and suitable quantity of water and sucrose is added to be configured to oral solution.
Clinical application example
The infant of intestines system lymphonodi abdominales inflammation totally 56 shows themselves in that there are the upper respiratory tract or enteric infection medical history in nearly half a month；Repeatedly
Abdominal pain, based on navel week pain；Belly color ultrasound shows multiple enlargements of lymph nodes.In all patients, male 34, female 22；Age 2~
4 years old 22,5~7 years old 19,8~10 years old 15, average 6.7 years old；The course of disease is most 3 days short, longest 22 days, 6 days average.Random point
For control group (28) and treatment group (28).Two groups of genders, age, courses of disease etc. compare that there was no significant difference, are comparable.
Treatment group: the Chinese herbal granules of method and the technique preparation according to the embodiment of the present invention 1 are taken, infant is every within 2~4 years old
Secondary to take 1/3 packet, 5~7 years old infant is each taking 2/3 packet, and 8~10 years old infant is each taking 1 packet, once in the morning and once at night.It is right
According to group；Intravenous infusion in physiological saline is added in Cefotaxime Sodium, daily lO0mg/kg；Life is added in Ceftriaxone Sodium, daily 80mg/kg
Manage intravenous infusion in salt water.Two groups equal medication one week.Medication after a week, the treatment results of each group is counted by following criterion of therapeutical effect:
Cure: abdominal pain and simultaneous disease disappear, and body temperature is normal, and belly color ultrasound checks lymphonodi mesenterici and restores normal.
Effective: the symptoms such as abdominal pain mitigate or disappear, and body temperature is normal, and belly color ultrasound shows that lymphonodi mesenterici reduces.
Invalid: colic symptoms improve less, and mesenterium film lymph node is unchanged.
Treatment results: for two groups of infants after treating, test group total effective rate is 92.86%, and control group total effective rate is
67.85%, test group total effective rate is apparently higher than control group.Two groups for the treatment of results are specifically shown in Table l.
1 test group of table and control group curative effect statistical result (example)
Claims (3)
1. a kind of application of Chinese materia medica preparation in the drug of preparation treatment children's intestines system lymphonodi abdominales inflammation, is prepared by raw material and auxiliary material
It forms, it is characterised in that: by weight, the raw material is by 3-4 parts of aloe, 35-42 parts of pedicellus cucurbitae, 24-26 parts of Verbena officinalis
It is formed with 10-14 parts of brassicae chinensis,semen；The preparation method comprises the following steps: the aloe for cleaning up and drying, pedicellus cucurbitae, Verbena officinalis, brassicae chinensis,semen are weighed,
Merge, add water to cook twice, collecting decoction, relative density is 1.15-1.20 when being concentrated under reduced pressure into 70 DEG C, and ethyl alcohol is added to make alcohol content
Percent by volume reach 75-85%, stir, stand, filtering, when filtrate decompression is concentrated into 70 DEG C relative density be 1.20-1.30
And it recycles ethyl alcohol and obtains concentrate.
2. application according to claim 1, it is characterised in that: the Chinese materia medica preparation is oral preparation.
3. application according to claim 2, it is characterised in that: the Chinese materia medica preparation is oral solution, granule, tablet or glue
Wafer.
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| CN201410206332.5A CN104000969B (en) | 2014-05-16 | 2014-05-16 | A kind of Chinese materia medica preparation for treating children's intestines system lymphonodi abdominales inflammation |
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| CN201410206332.5A CN104000969B (en) | 2014-05-16 | 2014-05-16 | A kind of Chinese materia medica preparation for treating children's intestines system lymphonodi abdominales inflammation |
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| CN104367711A (en) * | 2014-10-16 | 2015-02-25 | 青岛申达高新技术开发有限公司 | Pharmaceutical composition for treatment of mesenteric lymphadenitis in children |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349799A (en) * | 2000-10-19 | 2002-05-22 | 王伦桥 | Chinese medicine Hanhui prepn |
| CN1528417A (en) * | 2003-10-21 | 2004-09-15 | 李友良 | Medicine for treating acute bacillary dysentery and acute enteritis |
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2014
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349799A (en) * | 2000-10-19 | 2002-05-22 | 王伦桥 | Chinese medicine Hanhui prepn |
| CN1528417A (en) * | 2003-10-21 | 2004-09-15 | 李友良 | Medicine for treating acute bacillary dysentery and acute enteritis |
Non-Patent Citations (2)
| Title |
|---|
| 新清宁片治疗小儿感染性疾病疗效观察;徐莹等;《辽宁中医学院学报》;20030531;第5卷(第2期);第130-131页 * |
| 瓜蒂类药材药学研究进展;李娜等;《安徽农业科学》;20111231;第39卷(第14期);第8369-8370页 * |
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