CN104367887A - Wild jujube seed-containing pharmaceutical composition for treating diarrhea - Google Patents
Wild jujube seed-containing pharmaceutical composition for treating diarrhea Download PDFInfo
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Abstract
The invention discloses a wild jujube seed-containing pharmaceutical composition for treating diarrhea. The pharmaceutical composition is prepared from wild jujube seeds, dogwood fruits, coptis roots, valeriana jatamansi, atractylodes macrocephala, coix seeds, magnolia and phyllanthus urinaria. The pharmaceutical composition disclosed by the invention has the effects of regulating Qi and invigorating the spleen, reinforcing the stomach and tonifying the kidneys, clearing heat and drying dampness, promoting blood circulation and strengthening Yang and promoting Qi circulation and removing Qi stagnation, is remarkable in treatment effect on diarrhea, low in drug dosage and simple in prescription, is free from toxic or side effects on human bodies and is beneficial to popularization and application.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition being used for the treatment of diarrhoea, in particular to a kind of pharmaceutical composition being used for the treatment of diarrhoea containing Semen Ziziphi Spinosae, being specifically related to a kind of is the pharmaceutical composition that raw material is made by Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae.
Background technology
Diarrhoea, the traditional Chinese medical science is called has loose bowels, and is a kind of common sympton, and refer to that defecation frequency is significantly more than the frequency be on ordinary days accustomed to, excrement matter is thin, and moisture increases, and every day, feces volume was more than 200g, or containing non-digest food or pus and blood, mucus.Diarrhoea is normal with symptoms such as defecation urgency sense, anus discomfort, incontinences.Diarrhoea point acute and chronic two classes.Modern medicine belongs to digestive system disease diarrhoea, and clinical commonly have inflammatory bowel, functional gastrointestinal disorder and chronic diarrhea, as: acute gastroenteritis, functional dyspepsia, irritable bowel syndrome etc.Treatment mainly adopts antibiotic medicine, sulfa drugs, aid digestion medicine etc.Take western medicine diarrhoea and easily produce drug resistance, easily there is dysbacteriosis in prolonged and repeated use antibiotic, nonresponder can form chronic diarrhea and the clinical gastrointestinal dysfunction syndrome seen, and medical expense is high.
Therefore, how to develop a kind of rapid-action, short treating period, cost are low and the treatment that side effect is little diarrhoea medicine, be unanimously the unremitting pursue of medicine worker.
Summary of the invention
The object of the invention is to overcome above-mentioned deficiency existing in prior art, a kind of pharmaceutical composition being used for the treatment of diarrhoea containing Semen Ziziphi Spinosae is provided.This pharmaceutical composition has regulating qi-flowing for strengthening spleen, stomach reinforcing the kidney invigorating, heat clearing and damp drying, effect that is supporing yang, circulation of qi promoting removing food stagnancy of invigorating blood circulation, and its treatment diarrhoea is evident in efficacy, and dosage is little, and to human non-toxic's side effect, and prescription is simple, is beneficial to and applies.
In order to realize foregoing invention object, the invention provides following technical scheme:
The pharmaceutical composition being used for the treatment of diarrhoea containing Semen Ziziphi Spinosae of the present invention, it is the medicament be made up of following raw material: Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae.
In pharmaceutical composition of the present invention, Semen Ziziphi Spinosae is sweet, flat.Enter the heart, Liver Channel.Tranquilizing by nourishing the heart, arresting sweating.For insomnia, palpitation with fear, spontaneous perspiration, night sweat.
Fructus Corni, acid, tepor.Return liver, kidney channel.Liver and kidney tonifying, restrains astringent or styptic treatment for spontaneous sweating.For having a dizzy spell, soreness of the waist and knees, metrorrhagia, leukorrhagia, menorrhagia, seminal emission, the enuresis, large apogee sweating, weak body and prostration.
Rhizoma Coptidis, bitter, cold.GUIXIN, stomach, liver, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.Damp and hot for gastrointestinal, vomiting, dysentery, unconsciousness due to high fever, dysphoria and insomnia, heat in blood tells nosebleed, sore swollen toxin, glue ear, eczema, toothache due to stomach-fire.
Rhizoma valerianae latifoliae, acrid in the mouth; Micro-hardship; Warm in nature.Regulating the flow of Qi and the middle Jiao, dispelling cold and removing dampness; Promoting blood circulation and detumescence.Main abdominal distention; Tell and have loose bowels; Infantile malnutrition; Anemofrigid-damp arthralgia; Limb air water swells; Menoxenia; Traumatic injury; Furuncle.
The Rhizoma Atractylodis Macrocephalae, bitter, sweet, temperature; Return spleen, stomach warp.Air making-up and spleen enlivening, dampness diuretic, hidroschesis, antiabortive.For deficiency-weakness of spleen-QI, anorexia and loose stool, phlegm retention edema, exterior deficiency spontaneous perspiration, frequent fetal movement.
Semen Coicis, sweet, light, be slightly cold.Return spleen, stomach, lung meridian.Promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, damp eliminating eliminating impediment, clearing away heat and discharging pus.For dysuria, edema, beriberi, diarrhea due to hypofunction of the spleen, rheumatic arthralgia, muscle arteries and veins contraction is anxious, lung abscess, acute appendicitis.
Drymotaenium miyoshianum (Mak.) Mak., bitter, cold.Cure mainly red bleb wine, carbuncle edema, control alcoholic jaundice, diuresis, treat congenital deformity of the tongue.
Cacumen Securinegae Suffruticosae, micro-hardship, sweet, cool.Clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy.For oedema due to nephritis, urinary system infection, calculus, enteritis, dysentery, infantile malnutrition, eye keratitis, icterohepatitis.
Applicant finds through test of many times, is that pharmaceutical composition made by raw material, effectively can treats diarrhoea by Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae.
Preferably, described pharmaceutical composition is made up of the raw material of following weight: Semen Ziziphi Spinosae 5 ~ 20 parts, Fructus Corni 4 ~ 12 parts, Rhizoma Coptidis 4 ~ 12 parts, Rhizoma valerianae latifoliae 4 ~ 12 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 12 parts, Semen Coicis 1 ~ 8 part, Drymotaenium miyoshianum (Mak.) Mak. 4 ~ 12 parts and Cacumen Securinegae Suffruticosae 1 ~ 8 part.
Applicant finds through many experiments, and pharmaceutical composition of the present invention is made up of the raw material of above-mentioned weight, better can play the synergistic function of each raw material components, not only effectively can treat diarrhoea, instant effect simultaneously, dosage is little, has no side effect.
Further preferably, described pharmaceutical composition is made up of the raw material of following weight: Semen Ziziphi Spinosae 8 ~ 15 parts, Fructus Corni 5 ~ 10 parts, Rhizoma Coptidis 5 ~ 10 parts, Rhizoma valerianae latifoliae 5 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 5 ~ 10 parts, Semen Coicis 2 ~ 7 parts, Drymotaenium miyoshianum (Mak.) Mak. 6 ~ 10 parts and Cacumen Securinegae Suffruticosae 1 ~ 5 part.
Still more preferably, described pharmaceutical composition is made up of the raw material of following weight: Semen Ziziphi Spinosae 10 ~ 12 parts, Fructus Corni 6 ~ 8 parts, Rhizoma Coptidis 5 ~ 6 parts, Rhizoma valerianae latifoliae 6 ~ 7 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 9 parts, Semen Coicis 2 ~ 5 parts, Drymotaenium miyoshianum (Mak.) Mak. 6 ~ 7 parts and Cacumen Securinegae Suffruticosae 2 ~ 4 parts.
Preferably, to the best described pharmaceutical composition be made up of the raw material of following weight: Semen Ziziphi Spinosae 12 parts, Fructus Corni 6 parts, Rhizoma Coptidis 6 parts, Rhizoma valerianae latifoliae 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Semen Coicis 3 parts, Drymotaenium miyoshianum (Mak.) Mak. 6 parts and Cacumen Securinegae Suffruticosae 3 parts.
By preferably above, the curative effect of pharmaceutical composition can be improved further.
The dosage form of pharmaceutical composition of the present invention can be the existing pharmaceutical dosage form of any one in drop pill, tablet, capsule, soft capsule, powder, oral liquid, granule.
The preparation method of pharmaceutical composition of the present invention is as follows:
(1) by Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae mix homogeneously, add 80% ethanol of raw material gross weight 3 ~ 5 times of weight, reflux, extract, 2 ~ 4h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 8 ~ 10 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, make acceptable various pharmaceutical dosage form.
According to the needs of the various drug form of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
Preparation method of the present invention effectively can extract the effective ingredient in each crude drug, makes it better play the effect of Synergistic.
The present invention's various raw medicinal materials used are the Chinese crude drug meeting country or provincial standard and specify.The pharmaceutical composition for the treatment of diarrhoea of the present invention, based on theory of Chinese medical science, in conjunction with clinical practice, from Chinese medicine material treasure-house, filter out Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and the pure purification of tcm of Cacumen Securinegae Suffruticosae eight taste form, and regulate the weight of each raw material, make the effect playing Synergistic between each raw material, effectively can treat diarrhoea, regulating qi-flowing for strengthening spleen, stomach reinforcing the kidney invigorating, heat clearing and damp drying, supporing yang, circulation of qi promoting removing food stagnancy of invigorating blood circulation.Pharmaceutical composition instant effect of the present invention simultaneously, dosage is little, has no side effect.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
The pharmaceutical composition of the treatment diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Semen Ziziphi Spinosae 12g, Fructus Corni 6g, Rhizoma Coptidis 6g, Rhizoma valerianae latifoliae 6g, Rhizoma Atractylodis Macrocephalae 6g, Semen Coicis 3g, Drymotaenium miyoshianum (Mak.) Mak. 6g and Cacumen Securinegae Suffruticosae 3g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
(1) by Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae mix homogeneously, add 80% ethanol of raw material gross weight 5 times of weight, reflux, extract, 3h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 9 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, then add 80g calcium carbonate, 20g starch, adopt wet-mixed to granulate, after particle drying, adopt No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 2
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Semen Ziziphi Spinosae 5g, Fructus Corni 12g, Rhizoma Coptidis 4g, Rhizoma valerianae latifoliae 12g, Rhizoma Atractylodis Macrocephalae 4g, Semen Coicis 8g, Drymotaenium miyoshianum (Mak.) Mak. 12g and Cacumen Securinegae Suffruticosae 8g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
(1) by Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae mix homogeneously, add 80% ethanol of raw material gross weight 5 times of weight, reflux, extract, 3h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 9 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, then add 80g calcium carbonate, 20g starch, adopt wet-mixed to granulate, after particle drying, adopt No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 3
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Semen Ziziphi Spinosae 20g, Fructus Corni 4g, Rhizoma Coptidis 4g, Rhizoma valerianae latifoliae 4g, Rhizoma Atractylodis Macrocephalae 12g, Semen Coicis 1g, Drymotaenium miyoshianum (Mak.) Mak. 4g and Cacumen Securinegae Suffruticosae 2g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
(1) by Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae mix homogeneously, add 80% ethanol of raw material gross weight 5 times of weight, reflux, extract, 3h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 9 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, then add 80g calcium carbonate, 20g starch, adopt wet-mixed to granulate, after particle drying, adopt No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 4
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Semen Ziziphi Spinosae 10g, Fructus Corni 4g, Rhizoma Coptidis 8g, Rhizoma valerianae latifoliae 8g, Rhizoma Atractylodis Macrocephalae 7g, Semen Coicis 5g, Drymotaenium miyoshianum (Mak.) Mak. 10g and Cacumen Securinegae Suffruticosae 6g.
Above-mentioned raw materials is prepared into granule, and preparation method is as follows:
(1) by Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae mix homogeneously, add 80% ethanol of raw material gross weight 5 times of weight, reflux, extract, 2h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 8 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, mix with 100g sucrose, adopt the preparation technique of existing granule, make the pharmaceutical composition of granule.
Comparative example 1
The pharmaceutical composition of the treatment diarrhoea described in this comparative example, be made up of the raw material of following weight:
Fructus Corni 6g, Rhizoma Coptidis 6g, Rhizoma valerianae latifoliae 6g, Rhizoma Atractylodis Macrocephalae 6g, Semen Coicis 3g, Drymotaenium miyoshianum (Mak.) Mak. 6g and Cacumen Securinegae Suffruticosae 3g.
Adopt the preparation method described in embodiment 1, make the pharmaceutical composition of capsule.
Comparative example 2
The pharmaceutical composition of the treatment diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Semen Ziziphi Spinosae 12g, Fructus Corni 6g, Rhizoma Coptidis 6g, Rhizoma Atractylodis Macrocephalae 6g, Semen Coicis 3g, Drymotaenium miyoshianum (Mak.) Mak. 6g and Cacumen Securinegae Suffruticosae 3g.
Adopt the preparation method described in embodiment 1, make the pharmaceutical composition of capsule.
Embodiment 5
1. the Observation of Inhibition Effects of pair vibrio parahaemolytious propagation
Vibrio bacteria (Vibrio spp) belongs to vibrionaceae, be a class Gram-negative, tool polar flagella, can move, asporous rod-short antibacterial, be cause alimentary toxicosis common pathogen.The inhibitory action selecting vibrio bacteria vibrio parahaemolytious to observe pharmaceutical composition of the present invention to breed it.
The preparation of 1.1 Chinese medicinal liquors of the present invention: the pharmaceutical composition of capsule described in Example 1, pours out Dissolve things inside, spends the night with the water soaking of 10 times of weight, and filter, filtrate reduced in volume, obtains dry powder, weighs; Use water dissolution again, adopt coubling dilution prepare concentration be respectively 6,12,30,50, the solution of 100mg/ml.
The preparation of 1.2LB fluid medium: get peptone 0.5g, yeast extract 0.1g, ferric ammonium citrate 0.01g, physiological saline solution 90ml, be uniformly mixed, regulates pH to 7.6, is settled to 100ml, and conventional high-pressure is sterilized, and is LB fluid medium.
The preparation of 1.3LB agar plate: LB fluid medium is micro-boil under slowly add 2g agar powder while stirring.Use the NaOH adjust ph of 0.1mol/L to 7.6 while hot, the paved LB agar plate of routine operation.
The preparation of 1.4 bacterial strains: vibrio parahaemolytious is provided by preclinical medicine institute of Mountain Western Medicine S University, is stored in self-made medium inclined-plane, is put in 4 DEG C of refrigerators for subsequent use; After strain inoculation is streak culture, select colonies typical and be inoculated in LB fluid medium, cultivate 18-24h for 28 DEG C, is that 108/ml is for subsequent use by the dilution of bacterium liquid after continuous passage 3 times.
1.5 dull and stereotyped hole method bacteriostatic tests: get bacterium liquid 200 μ l routine on superclean bench and coat LB agar plate surface; Turn with ophthalmic cornea ring and equidistantly make a call to 5 holes on LB agar plate, aperture, every hole is 6.5mm, and hole agar chosen by lancet; The Chinese medicinal liquor 0.15ml of the present invention of variable concentrations is dripped respectively in hole; Plate is placed in 28 DEG C of constant incubators and cultivates 48h; Antibacterial circle diameter is measured with slide gauge.
1.6 experimental results: result shows, concentration is respectively 6,12,30,50, the pharmaceutical composition of the present invention of 100mg/ml all can form larger inhibition zone, compare with matched group, P value is all less than 0.01, illustrate that pharmaceutical composition of the present invention has the effect suppressing vibrio parahaemolytious propagation, the results are shown in Table 1.
Table 1: the inhibitory action that pharmaceutical composition of the present invention is bred vibrio parahaemolytious
Note: compare with matched group,
*p < 0.01.
2. clinical trial
2.1 diagnosis basis: according to the regulation of " People's Republic of China's traditional Chinese medicine industry standard---Chinese medical disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis of having loose bowels ", soft stools or as water sample, increased frequency; The diseases such as abdominal distention stomachache can be accompanied; Acute sudden attack of spouting diarrhea onset is unexpected, and the course of disease is short; Can with the disease such as aversion to cold, heating; Chronic chronic diarrhea onset is slow, and the course of disease is longer, recurrent exerbation, time light time heavy; Improper diet, can to bring out by cold and cool or emotion changes; Visible red, the leukocyte a little of stool routine examination, stool cultivates pathogenic bacterium positive or negative; Make x-ray barium enema or intestinal fiberscopy if desired.
2.2 general data: pharmaceutical composition of the present invention is used for clinical observation case 150 example, is divided at random five groups (experimental group 1 ~ 3 and matched groups 1 ~ 3), often organizes 30 people.
Experimental group 1:30 example, man 15 example, female 15 example, the age is 11 ~ 68 years old, average 22 years old.All meet above-mentioned diagnosis basis.
Experimental group 2:30 example, man 15 example, female 15 example, the age is 10 ~ 59 years old, average 23 years old.All meet above-mentioned diagnosis basis.
Experimental group 3:30 example, man 15 example, female 15 example, the age is 8 ~ 69 years old, average 25 years old.All meet above-mentioned diagnosis basis.
Matched group 1:30 example, man 15 example, female 15 example, the age is 8 ~ 58 years old, average 21 years old.All meet above-mentioned diagnosis basis.
Matched group 2:30 example, man 15 example, female 15 example, the age is 9 ~ 64 years old, average 22 years old.All meet above-mentioned diagnosis basis.
Above five groups of physical data comparing differences are without significantly.
2.3 therapeutic evaluatioies: according to the regulation of " People's Republic of China's traditional Chinese medicine industry standard---Chinese medical disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis of having loose bowels, syndrome-classification, efficacy evaluation ", cure: stool is normal, other transference cures, Clinical Laboratory is normal; Take a turn for the better: times of defecation obviously reduces, other symptoms are improved; Do not heal: symptom has no improvement.
2.4 medications:
Experimental group 1: take pharmaceutical composition prepared by the embodiment of the present invention 1, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Experimental group 2: take pharmaceutical composition prepared by the embodiment of the present invention 2, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Experimental group 3: take pharmaceutical composition prepared by the embodiment of the present invention 3, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Matched group 1: the pharmaceutical composition taking comparative example 1 of the present invention preparation, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Matched group 2: the pharmaceutical composition taking comparative example 2 of the present invention preparation, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
2.5 therapeutic outcome
The therapeutic outcome of each group of patient is as shown in table 2.
The therapeutic outcome of patient respectively organized by table 2.
Note: cure rate=healing number of cases ÷ tests number of cases × 100%; Total effective rate=(curing number of cases+improvement number of cases) ÷ tests number of cases × 100%.
In experimentation, all do not find untoward reaction before and after most of patient medication of experimental group 1 ~ 3 and matched group 1 ~ 2, only have 1 ~ 4 routine patient to occur the discomforts such as dizzy, by the equal spontaneous remission of diet modification, non-drug withdrawal, shows that pharmaceutical composition of the present invention has no side effect to patient body.
The cure rate of experimental group in table 21 ~ 3 with comparative example 1 ~ 2 is compared with total effective rate, the cure rate of experimental group and total effective rate improve 13 ~ 36%, 13 ~ 20% respectively, show that pharmaceutical composition of the present invention needs the mutual compatibility of each raw material components, play the effect of Synergistic, just can reach best therapeutic effect, lack the curative effect that any Herba indigoferae Pseudotinctoriae all significantly can reduce pharmaceutical composition.
Compared with total effective rate by the cure rate of experimental group in table 21 ~ 3, the cure rate of experimental group 1 and total effective rate comparatively experimental group 2 improve 16%, 0% respectively, and comparatively experimental group 3 improves 20% respectively, and 3%; Showing that the pharmaceutical composition described in embodiment 1 achieves non-obvious effect, is optimum implementation of the present invention.
Claims (5)
1. the pharmaceutical composition being used for the treatment of diarrhoea containing Semen Ziziphi Spinosae, it is characterized in that, it is the medicament be made up of following raw material: Semen Ziziphi Spinosae, Fructus Corni, Rhizoma Coptidis, Rhizoma valerianae latifoliae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Drymotaenium miyoshianum (Mak.) Mak. and Cacumen Securinegae Suffruticosae.
2. pharmaceutical composition according to claim 1, it is characterized in that, the weight of described each raw material is: Semen Ziziphi Spinosae 5 ~ 20 parts, Fructus Corni 4 ~ 12 parts, Rhizoma Coptidis 4 ~ 12 parts, Rhizoma valerianae latifoliae 4 ~ 12 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 12 parts, Semen Coicis 1 ~ 8 part, Drymotaenium miyoshianum (Mak.) Mak. 4 ~ 12 parts and Cacumen Securinegae Suffruticosae 1 ~ 8 part.
3. pharmaceutical composition according to claim 2, it is characterized in that, the weight of described each raw material is: Semen Ziziphi Spinosae 8 ~ 15 parts, Fructus Corni 5 ~ 10 parts, Rhizoma Coptidis 5 ~ 10 parts, Rhizoma valerianae latifoliae 5 ~ 10 parts, the Rhizoma Atractylodis Macrocephalae 5 ~ 10 parts, Semen Coicis 2 ~ 7 parts, Drymotaenium miyoshianum (Mak.) Mak. 6 ~ 10 parts and Cacumen Securinegae Suffruticosae 1 ~ 5 part.
4. pharmaceutical composition according to claim 3, it is characterized in that, the weight of described each raw material is: Semen Ziziphi Spinosae 10 ~ 12 parts, Fructus Corni 6 ~ 8 parts, Rhizoma Coptidis 5 ~ 6 parts, Rhizoma valerianae latifoliae 6 ~ 7 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 9 parts, Semen Coicis 2 ~ 5 parts, Drymotaenium miyoshianum (Mak.) Mak. 6 ~ 7 parts and Cacumen Securinegae Suffruticosae 2 ~ 4 parts.
5. pharmaceutical composition according to claim 4, is characterized in that, the weight of described each raw material is: Semen Ziziphi Spinosae 12 parts, Fructus Corni 6 parts, Rhizoma Coptidis 6 parts, Rhizoma valerianae latifoliae 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Semen Coicis 3 parts, Drymotaenium miyoshianum (Mak.) Mak. 6 parts and Cacumen Securinegae Suffruticosae 3 parts.
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