CN104435975A - Tuckahoe-containing pharmaceutical composition for treating diarrhea - Google Patents
Tuckahoe-containing pharmaceutical composition for treating diarrhea Download PDFInfo
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a tuckahoe-containing pharmaceutical composition for treating diarrhea. The tuckahoe-containing pharmaceutical composition is prepared from raw materials including tuckahoe, patchouli, magnolia officinalis, sanguisorba officinalis, amomum cardamomum, fructus evodiae and rhizoma dioscoreae nipponicae. The pharmaceutical composition disclosed by the invention has the effects of regulating qi flow for strengthening the spleen, reinforcing the stomach and tonifying the kidneys, clearing away heat and drying dampness, activating blood circulation and tonifying yang as well as promoting qi and removing qi stagnation, and is remarkable in effect on treating diarrhea, small in dosage, free of toxic or side effects on a human body, simple in prescription and beneficial to popularization and application.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition being used for the treatment of diarrhoea, in particular to a kind of pharmaceutical composition being used for the treatment of diarrhoea containing Poria, be specifically related to a kind of peace by Poria, Herba Pogostemonis, Cortex Magnoliae Officinalis, Radix Sanguisorbae, Fructus Amomi Rotundus, Fructus Evodiae and chicken and remember that sieve is the pharmaceutical composition that raw material is made.
Background technology
Diarrhoea, the traditional Chinese medical science is called has loose bowels, and is a kind of common sympton, and refer to that defecation frequency is significantly more than the frequency be on ordinary days accustomed to, excrement matter is thin, and moisture increases, and every day, feces volume was more than 200g, or containing non-digest food or pus and blood, mucus.Diarrhoea is normal with symptoms such as defecation urgency sense, anus discomfort, incontinences.Diarrhoea point acute and chronic two classes.Modern medicine belongs to digestive system disease diarrhoea, and clinical commonly have inflammatory bowel, functional gastrointestinal disorder and chronic diarrhea, as: acute gastroenteritis, functional dyspepsia, irritable bowel syndrome etc.Treatment mainly adopts antibiotic medicine, sulfa drugs, aid digestion medicine etc.Take western medicine diarrhoea and easily produce drug resistance, easily there is dysbacteriosis in prolonged and repeated use antibiotic, nonresponder can form chronic diarrhea and the clinical gastrointestinal dysfunction syndrome seen, and medical expense is high.
Therefore, how to develop a kind of rapid-action, short treating period, cost are low and the treatment that side effect is little diarrhoea medicine, be unanimously the unremitting pursue of medicine worker.
Summary of the invention
The object of the invention is to overcome above-mentioned deficiency existing in prior art, a kind of pharmaceutical composition being used for the treatment of diarrhoea containing Poria is provided.This pharmaceutical composition has regulating qi-flowing for strengthening spleen, stomach reinforcing the kidney invigorating, heat clearing and damp drying, effect that is supporing yang, circulation of qi promoting removing food stagnancy of invigorating blood circulation, and its treatment diarrhoea is evident in efficacy, and dosage is little, and to human non-toxic's side effect, and prescription is simple, is beneficial to and applies.
In order to realize foregoing invention object, the invention provides following technical scheme:
The pharmaceutical composition being used for the treatment of diarrhoea containing Poria of the present invention, it is the medicament be made up of following raw material: Poria, Herba Pogostemonis, Cortex Magnoliae Officinalis, Radix Sanguisorbae, Fructus Amomi Rotundus, Fructus Evodiae and chicken peace note sieve.
In pharmaceutical composition of the present invention, Poria is sweet, light, flat.GUIXIN, spleen, kidney channel.There is the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.
Herba Pogostemonis, pungent, tepor.Return spleen, stomach, lung meridian.Removing dampness, expelling summer-heat, preventing or arresting vomiting.
Cortex Magnoliae Officinalis, bitter; Pungent; Warm in nature.Return spleen channel; Stomach warp; Large intestine channel.Cure mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.
Radix Sanguisorbae, cold in nature, bitter in the mouth acid, nontoxic; Return liver, lung, kidney and large intestine channel.There is cooling blood for hemostasis, heat-clearing and toxic substances removing, train clear yin nourishing, the effects such as detumescence sore.
Fructus Amomi Rotundus, acrid in the mouth, warm in nature, return lung, spleen, stomach warp.Effect removing dampness, circulation of qi promoting, warming middle-JIAO, preventing or arresting vomiting.
Fructus Evodiae, warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness, headache due to JUE YIN disorder, and the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.
Chicken peace note sieve, acrid, bitter, warm.There is the function of blood circulation promoting regulates qi, dispelling, collateral-activating, reducing swelling and alleviating pain.
Applicant finds through test of many times, is that pharmaceutical composition made by raw material, effectively can treats diarrhoea by Poria, Herba Pogostemonis, Cortex Magnoliae Officinalis, Radix Sanguisorbae, Fructus Amomi Rotundus, Fructus Evodiae and chicken peace note sieve.
Preferably, described pharmaceutical composition is made up of the raw material of following weight: 1 ~ 8 part, Poria, Herba Pogostemonis 5 ~ 20 parts, Cortex Magnoliae Officinalis 8 ~ 18 parts, Radix Sanguisorbae 3 ~ 11 parts, Fructus Amomi Rotundus 6 ~ 17 parts, Fructus Evodiae 2 ~ 11 parts and chicken peace note sieve 5 ~ 20 parts.
Applicant finds through many experiments, and pharmaceutical composition of the present invention is made up of the raw material of above-mentioned weight, better can play the synergistic function of each raw material components, not only effectively can treat diarrhoea, instant effect simultaneously, dosage is little, has no side effect.
Further preferably, described pharmaceutical composition is made up of the raw material of following weight: 2 ~ 6 parts, Poria, Herba Pogostemonis 10 ~ 18 parts, Cortex Magnoliae Officinalis 10 ~ 16 parts, Radix Sanguisorbae 3 ~ 9 parts, Fructus Amomi Rotundus 6 ~ 12 parts, Fructus Evodiae 3 ~ 8 parts and chicken peace note sieve 8 ~ 17 parts.
Still more preferably, described pharmaceutical composition is made up of the raw material of following weight: 3 ~ 5 parts, Poria, Herba Pogostemonis 12 ~ 15 parts, Cortex Magnoliae Officinalis 12 ~ 14 parts, Radix Sanguisorbae 4 ~ 7 parts, Fructus Amomi Rotundus 7 ~ 9 parts, Fructus Evodiae 5 ~ 8 parts and chicken peace note sieve 10 ~ 15 parts.
Preferably, to the best described pharmaceutical composition be made up of the raw material of following weight: 3 parts, Poria, Herba Pogostemonis 15 parts, Cortex Magnoliae Officinalis 12 parts, Radix Sanguisorbae 5 parts, Fructus Amomi Rotundus 9 parts, Fructus Evodiae 6 parts and chicken peace note sieve 12 parts.
By preferably above, the curative effect of pharmaceutical composition can be improved further.
The dosage form of pharmaceutical composition of the present invention can be the existing pharmaceutical dosage form of any one in drop pill, tablet, capsule, soft capsule, powder, oral liquid, granule.
The preparation method of pharmaceutical composition of the present invention is as follows:
The raw material of above-mentioned weight is added respectively 50 ~ 70% ethanol of 8 ~ 10 times of volumes, reflux, extract, three times, extraction time is respectively 2.0h, 1.5h, 1.5h, filter, merge 3 filtrates, by each concentrated solution mix homogeneously after recovery ethanol also concentrates, dry, make acceptable various pharmaceutical dosage form.
According to the needs of the various drug form of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
Preparation method of the present invention effectively can extract the effective ingredient in each crude drug, makes it better play the effect of Synergistic.
The present invention's various raw medicinal materials used are the Chinese crude drug meeting country or provincial standard and specify.The pharmaceutical composition for the treatment of diarrhoea of the present invention, based on theory of Chinese medical science, in conjunction with clinical practice, from Chinese medicine material treasure-house, filter out Poria, Herba Pogostemonis, Cortex Magnoliae Officinalis, Radix Sanguisorbae, Fructus Amomi Rotundus, Fructus Evodiae and the pure purification of tcm of chicken peace note sieve seven taste form, and regulate the weight of each raw material, make the effect playing Synergistic between each raw material, effectively can treat diarrhoea, regulating qi-flowing for strengthening spleen, stomach reinforcing the kidney invigorating, heat clearing and damp drying, supporing yang, circulation of qi promoting removing food stagnancy of invigorating blood circulation.Pharmaceutical composition instant effect of the present invention simultaneously, dosage is little, has no side effect.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
The pharmaceutical composition of the treatment diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Poria 3g, Herba Pogostemonis 15g, Cortex Magnoliae Officinalis 12g, Radix Sanguisorbae 5g, Fructus Amomi Rotundus 9g, Fructus Evodiae 6g and chicken peace note sieve 12g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
The raw material of above-mentioned weight is added respectively 70% ethanol of 10 times of volumes, reflux, extract, three times, extraction time is respectively 2.0h, 1.5h, 1.5h, filter, merge 3 filtrates, by each concentrated solution mix homogeneously after recovery ethanol also concentrates, dry, then 50g calcium carbonate, 10g starch is added, employing wet-mixed is granulated, and after particle drying, adopts No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 2
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Poria 2g, Herba Pogostemonis 18g, Cortex Magnoliae Officinalis 8g, Radix Sanguisorbae 3g, Fructus Amomi Rotundus 15g, Fructus Evodiae 10g and chicken peace note sieve 7g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
The raw material of above-mentioned weight is added respectively 70% ethanol of 10 times of volumes, reflux, extract, three times, extraction time is respectively 2.0h, 1.5h, 1.5h, filter, merge 3 filtrates, by each concentrated solution mix homogeneously after recovery ethanol also concentrates, dry, then 50g calcium carbonate, 10g starch is added, employing wet-mixed is granulated, and after particle drying, adopts No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 3
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Poria 5g, Herba Pogostemonis 9g, Cortex Magnoliae Officinalis 10g, Radix Sanguisorbae 8g, Fructus Amomi Rotundus 6g, Fructus Evodiae 5g and chicken peace note 20g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
The raw material of above-mentioned weight is added respectively 60% ethanol of 9 times of volumes, reflux, extract, three times, extraction time is respectively 2.0h, 1.5h, 1.5h, filter, merge 3 filtrates, by each concentrated solution mix homogeneously after recovery ethanol also concentrates, dry, then 50g calcium carbonate, 10g starch is added, employing wet-mixed is granulated, and after particle drying, adopts No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 4
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Poria 8g, Herba Pogostemonis 5g, Cortex Magnoliae Officinalis 18g, Radix Sanguisorbae 11g, Fructus Amomi Rotundus 6g, Fructus Evodiae 2g and chicken peace note sieve 10g.
Above-mentioned raw materials is prepared into tablet, and preparation method is as follows:
The raw material of above-mentioned weight is added respectively 60% ethanol of 9 times of volumes, reflux, extract, three times, extraction time is respectively 2.0h, 1.5h, 1.5h, filters, merges 3 filtrates, by each concentrated solution mix homogeneously after recovery ethanol also concentrates, drying, with 60g starch, 10g polyvidone mixes, adopt existing pressed-disc technique, make the pharmaceutical composition of tablet.
Comparative example 1
The pharmaceutical composition of the blood fat reducing described in this comparative example, be made up of the raw material of following weight:
Herba Pogostemonis 15g, Cortex Magnoliae Officinalis 12g, Radix Sanguisorbae 5g, Fructus Amomi Rotundus 9g, Fructus Evodiae 6g and chicken peace note sieve 12g.
Adopt the preparation method described in embodiment 1, make the pharmaceutical composition of capsule.
Comparative example 2
The pharmaceutical composition of the blood fat reducing described in the present embodiment, be made up of the raw material of following weight:
Poria 3g, Herba Pogostemonis 15g, Cortex Magnoliae Officinalis 12g, Fructus Amomi Rotundus 9g, Fructus Evodiae 6g and chicken peace note sieve 12g.
Adopt the preparation method described in embodiment 1, make the pharmaceutical composition of capsule.
Embodiment 5
1. the Observation of Inhibition Effects of pair vibrio parahaemolytious propagation
Vibrio bacteria (Vibrio spp) belongs to vibrionaceae, be a class Gram-negative, tool polar flagella, can move, asporous rod-short antibacterial, be cause alimentary toxicosis common pathogen.The inhibitory action selecting vibrio bacteria vibrio parahaemolytious to observe pharmaceutical composition of the present invention to breed it.
The preparation of 1.1 Chinese medicinal liquors of the present invention: the pharmaceutical composition of capsule described in Example 1, pours out Dissolve things inside, spends the night with the water soaking of 10 times of weight, and filter, filtrate reduced in volume, obtains dry powder, weighs; Use water dissolution again, adopt coubling dilution prepare concentration be respectively 6,12,30,50, the solution of 100mg/ml.
The preparation of 1.2LB fluid medium: get peptone 0.5g, yeast extract 0.1g, ferric ammonium citrate 0.01g, physiological saline solution 90ml, be uniformly mixed, regulates pH to 7.6, is settled to 100ml, and conventional high-pressure is sterilized, and is LB fluid medium.
The preparation of 1.3LB agar plate: LB fluid medium is micro-boil under slowly add 2g agar powder while stirring.Use the NaOH adjust ph of 0.1mol/L to 7.6 while hot, the paved LB agar plate of routine operation.
The preparation of 1.4 bacterial strains: vibrio parahaemolytious is provided by preclinical medicine institute of Mountain Western Medicine S University, is stored in self-made medium inclined-plane, is put in 4 DEG C of refrigerators for subsequent use; After strain inoculation is streak culture, select colonies typical and be inoculated in LB fluid medium, cultivate 18-24h for 28 DEG C, is that 108/ml is for subsequent use by the dilution of bacterium liquid after continuous passage 3 times.
1.5 dull and stereotyped hole method bacteriostatic tests: get bacterium liquid 200 μ l routine on superclean bench and coat LB agar plate surface; Turn with ophthalmic cornea ring and equidistantly make a call to 5 holes on LB agar plate, aperture, every hole is 6.5mm, and hole agar chosen by lancet; The Chinese medicinal liquor 0.15ml of the present invention of variable concentrations is dripped respectively in hole; Plate is placed in 28 DEG C of constant incubators and cultivates 48h; Antibacterial circle diameter is measured with slide gauge.
1.6 experimental results: result shows, concentration is respectively 6,12,30,50, the pharmaceutical composition of the present invention of 100mg/ml all can form larger inhibition zone, compare with matched group, P value is all less than 0.01, illustrate that pharmaceutical composition of the present invention has the effect suppressing vibrio parahaemolytious propagation, the results are shown in Table 1.
Table 1: the inhibitory action that pharmaceutical composition of the present invention is bred vibrio parahaemolytious
Note: compare with matched group,
*p < 0.01.
2. clinical trial
2.1 diagnosis basis: according to the regulation of " People's Republic of China's traditional Chinese medicine industry standard---Chinese medical disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis of having loose bowels ", soft stools or as water sample, increased frequency; The diseases such as abdominal distention stomachache can be accompanied; Acute sudden attack of spouting diarrhea onset is unexpected, and the course of disease is short; Can with the disease such as aversion to cold, heating; Chronic chronic diarrhea onset is slow, and the course of disease is longer, recurrent exerbation, time light time heavy; Improper diet, can to bring out by cold and cool or emotion changes; Visible red, the leukocyte a little of stool routine examination, stool cultivates pathogenic bacterium positive or negative; Make x-ray barium enema or intestinal fiberscopy if desired.
2.2 general data: pharmaceutical composition of the present invention is used for clinical observation case 150 example, is divided at random five groups (experimental group 1 ~ 3 and matched groups 1 ~ 3), often organizes 30 people.
Experimental group 1:30 example, man 15 example, female 15 example, the age is 9 ~ 62 years old, average 25 years old.All meet above-mentioned diagnosis basis.
Experimental group 2:30 example, man 16 example, female 14 example, the age is 10 ~ 60 years old, average 22 years old.All meet above-mentioned diagnosis basis.
Experimental group 3:30 example, man 15 example, female 15 example, the age is 10 ~ 59 years old, average 22 years old.All meet above-mentioned diagnosis basis.
Matched group 1:30 example, man 14 example, female 16 example, the age is 11 ~ 65 years old, average 25 years old.All meet above-mentioned diagnosis basis.
Matched group 2:30 example, man 15 example, female 15 example, the age is 12 ~ 63 years old, average 20 years old.All meet above-mentioned diagnosis basis.
Above five groups of physical data comparing differences are without significantly.
2.3 therapeutic evaluatioies: according to the regulation of " People's Republic of China's traditional Chinese medicine industry standard---Chinese medical disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis of having loose bowels, syndrome-classification, efficacy evaluation ", cure: stool is normal, other transference cures, Clinical Laboratory is normal; Take a turn for the better: times of defecation obviously reduces, other symptoms are improved; Do not heal: symptom has no improvement.
2.4 medications:
Experimental group 1: take pharmaceutical composition prepared by the embodiment of the present invention 1, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Experimental group 2: take pharmaceutical composition prepared by the embodiment of the present invention 2, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Experimental group 3: take pharmaceutical composition prepared by the embodiment of the present invention 3, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Matched group 1: the pharmaceutical composition taking comparative example 1 of the present invention preparation, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Matched group 2: the pharmaceutical composition taking comparative example 2 of the present invention preparation, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
2.5 therapeutic outcome
The therapeutic outcome of each group of patient is as shown in table 2.
The therapeutic outcome of patient respectively organized by table 2.
Note: cure rate=healing number of cases ÷ tests number of cases × 100%; Total effective rate=(curing number of cases+improvement number of cases) ÷ tests number of cases × 100%.
In experimentation, all do not find untoward reaction before and after most of patient medication of experimental group 1 ~ 3 and matched group 1 ~ 2, only have 1 ~ 3 routine patient to occur the discomforts such as dizzy, by the equal spontaneous remission of diet modification, non-drug withdrawal, shows that pharmaceutical composition of the present invention has no side effect to patient body.
The cure rate of experimental group in table 21 ~ 3 with comparative example 1 ~ 2 is compared with total effective rate, the cure rate of experimental group and total effective rate improve about 30%, about 20% respectively, show that pharmaceutical composition of the present invention needs the mutual compatibility of each raw material components, play the effect of Synergistic, just can reach best therapeutic effect, lack the curative effect that any Herba indigoferae Pseudotinctoriae all significantly can reduce pharmaceutical composition.
Compared with total effective rate by the cure rate of experimental group in table 21 ~ 3, the cure rate of experimental group 1 and total effective rate comparatively experimental group 2 improve 13%, 4% respectively, and comparatively experimental group 3 improves 17% respectively, and 7%; Showing that the pharmaceutical composition described in embodiment 1 achieves non-obvious effect, is optimum implementation of the present invention.
Claims (5)
1. the pharmaceutical composition being used for the treatment of diarrhoea containing Poria, it is characterized in that, it is the medicament be made up of following raw material: Poria, Herba Pogostemonis, Cortex Magnoliae Officinalis, Radix Sanguisorbae, Fructus Amomi Rotundus, Fructus Evodiae and chicken peace note sieve.
2. pharmaceutical composition according to claim 1, it is characterized in that, the weight of described each raw material is: 1 ~ 8 part, Poria, Herba Pogostemonis 5 ~ 20 parts, Cortex Magnoliae Officinalis 8 ~ 18 parts, Radix Sanguisorbae 3 ~ 11 parts, Fructus Amomi Rotundus 6 ~ 17 parts, Fructus Evodiae 2 ~ 11 parts and chicken peace note sieve 5 ~ 20 parts.
3. pharmaceutical composition according to claim 2, it is characterized in that, the weight of described each raw material is: 2 ~ 6 parts, Poria, Herba Pogostemonis 10 ~ 18 parts, Cortex Magnoliae Officinalis 10 ~ 16 parts, Radix Sanguisorbae 3 ~ 9 parts, Fructus Amomi Rotundus 6 ~ 12 parts, Fructus Evodiae 3 ~ 8 parts and chicken peace note sieve 8 ~ 17 parts.
4. pharmaceutical composition according to claim 3, it is characterized in that, the weight of described each raw material is: 3 ~ 5 parts, Poria, Herba Pogostemonis 12 ~ 15 parts, Cortex Magnoliae Officinalis 12 ~ 14 parts, Radix Sanguisorbae 4 ~ 7 parts, Fructus Amomi Rotundus 7 ~ 9 parts, Fructus Evodiae 5 ~ 8 parts and chicken peace note sieve 10 ~ 15 parts.
5. pharmaceutical composition according to claim 4, is characterized in that, the weight of described each raw material is: 3 parts, Poria, Herba Pogostemonis 15 parts, Cortex Magnoliae Officinalis 12 parts, Radix Sanguisorbae 5 parts, Fructus Amomi Rotundus 9 parts, Fructus Evodiae 6 parts and chicken peace note sieve 12 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410629587.2A CN104435975A (en) | 2014-11-11 | 2014-11-11 | Tuckahoe-containing pharmaceutical composition for treating diarrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410629587.2A CN104435975A (en) | 2014-11-11 | 2014-11-11 | Tuckahoe-containing pharmaceutical composition for treating diarrhea |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5375318A (en) * | 1976-12-14 | 1978-07-04 | Nippon Kayaku Co Ltd | Prophicactics and remedies for diarrhea of young mammals |
| CN1433803A (en) * | 2003-02-19 | 2003-08-06 | 温文斌 | Medicine composition for treating abdominal pain and diarrhea |
-
2014
- 2014-11-11 CN CN201410629587.2A patent/CN104435975A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5375318A (en) * | 1976-12-14 | 1978-07-04 | Nippon Kayaku Co Ltd | Prophicactics and remedies for diarrhea of young mammals |
| CN1433803A (en) * | 2003-02-19 | 2003-08-06 | 温文斌 | Medicine composition for treating abdominal pain and diarrhea |
Non-Patent Citations (4)
| Title |
|---|
| 周纯洁: "中药为主治疗小儿秋季腹泻100例", 《湖北中医杂志》 * |
| 李秋华等: "小儿止泻液的药理研究", 《湖北中医杂志》 * |
| 祁公任等: "《现代实用临床中药学》", 31 May 2010, 化学工业出版社 * |
| 谢英彪: "《中药养生老方精粹》", 31 January 2014, 凤凰出版传媒股份有限公司 江苏科学技术出版社 * |
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