CN103006710B - Chinese medicinal preparation for treating diarrhea - Google Patents
Chinese medicinal preparation for treating diarrhea Download PDFInfo
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- CN103006710B CN103006710B CN201210521363.0A CN201210521363A CN103006710B CN 103006710 B CN103006710 B CN 103006710B CN 201210521363 A CN201210521363 A CN 201210521363A CN 103006710 B CN103006710 B CN 103006710B
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Abstract
Relating to the field of internal medicine, the invention provides a Chinese medicinal preparation for treating diarrhea so as to solve the treatment problems of diarrhea caused by various reasons. The Chinese medicinal preparation is prepared by: mixing Galla chinensis, alum, minium and oysters uniformly, crushing the mixture into fine powder, and sieving the powder through a sieve of 80-100 meshes; heating beeswax and maintaining the temperature at 60-70DEG C, adding the medicinal powder and mixing them evenly; and making the mixture into pills. Specifically, the compatibility of Galla chinensis, alum and beeswax can achieve the efficacy of relieving diarrhea with astringents and astringing dampness and sores; the oysters can induce astringency and arrest discharge, and also can soothe the nerves; and the supplemented minium and beeswax have the efficacy of detoxification and tissue regeneration promotion. The Chinese medicinal preparation provided in the invention can be used for mainly treating diarrhea symptoms by eliminating dampness. Also with the characteristics of simple administration, safe and convenient clinical medication, the Chinese medicinal preparation has broad clinical application prospects.
Description
Technical field
The present invention relates to internal medicine field, specifically a kind of Chinese medicine preparation for the treatment of diarrhoea.
Background technology
Diarrhoea is one of developing country's morbidity and main causes of death, and the whole world has 1,800,000 people to die from diarrhoea every year, and wherein 90% is 5 years old following child, and most death occurs in developing country.The factor that impact diarrhoea occurs is a lot, and except drinking-water factor, food and interpersonal contact transmission are also main causes, and diarrhoea is also relevant with the social factor such as the level of economic development in addition.
The traditional Chinese medical science thinks, diarrhoea can be divided into deficiency and excess emergency.Acute person mostly is excess syndrome, with cold-damp, damp and hot, indigestion diarrhea is common; Chronic diarrhea person takes advantage of spleen, weakness of the spleen and stomach, kidney yang deficiency common with irritability, taking deficiency syndrome as main.All patient's condition are hurried, distension and fullness in the abdomen, and abdominal pain with tenderness, rushes down rear alleviation of pain, dysuria person, mostly empirical; All courses of disease are longer, stomachache not very and pain relieved by pressing, normal urination, mouthful not thirsty, belong to deficiency syndrome more.Excrement matter is clear as water, and stomachache is liked warm aqueous-grainy diarrhea, belongs to the card of cold-damp more; Feces is yellowish-brown, and taste is smelly heavier, rushes down lower urgently, and burning sensation of the anus, belongs to damp-heat syndrome more.Chronic diarrhea protracted course of disease, fatigue and weakness, slightly improper diet, or overstrain and recurrence, mainly with insufficiency of the spleen be main; Have loose bowels and repeatedly do not heal, often recur because feelings will is unsuccessful, mostly be the card of stagnation of liver-QI gram spleen; Diarrhoea, aqueous-grainy diarrhea soreness of waist cold extremities, mostly is insufficiency of kidney-YANG.
Chinese medicine preparation of the present invention can be controlled the incessant chronic diarrhea that a variety of causes causes, is subject to suffer from diarrhoea due to damp and hot heresy but cure mainly.Stagnation of damp-heat, impairing the spleen and stomach, large intestine separating clear and excreting turbid, conduction function mistake department, causes diarrhoea.The common stomachache of having loose bowels of this type of patient, chronic diarrhea protracted course of disease, abnormal smells from the patient is smelly dirty, burning sensation of the anus, or see the raw skin ulcer of anus suppuration.
Summary of the invention
The present invention is for the diarrhea treatment problem that solves a variety of causes and cause and a kind of Chinese medicine preparation for the treatment of diarrhoea is provided.
The present invention is realized by following technical scheme, and a kind of Chinese medicine preparation for the treatment of diarrhoea is made up of the raw material of following weight portion: Galla Chinensis 25-100 part, Alumen 10-20 part, Plumbum preparatium 5-15 part, Concha Ostreae 10-20 part, Cera Flava 25-100 part.Above medicine Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae are crushed to fine-powdered after mixing, and cross 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make the heavily pill for 5g.
The optimum ratio scheme of each component of Chinese medicine preparation of the present invention is: 50 parts of Galla Chinensiss, 15 parts of Alumens, 10 parts of Plumbum preparatiums, 15 parts of Concha Ostreaes, 50 parts, Cera Flava.The Chinese medicine preparation preparation method for the treatment of diarrhoea of the present invention is: described medicine Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae are crushed to fine-powdered after mixing, and crosses 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make the heavily pill for 5g.
In Chinese medicine preparation of the present invention, Galla Chinensis acid, puckery, cold, returns lung, large intestine, kidney channel; Astringe the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating hemostasis, removing dampness sore, for chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, night sweat, quench one's thirst, have blood in stool hemorrhoidal bleeding, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.Alumen acid, puckery, cold, returns lung, spleen, liver, large intestine channel, external removing toxic substances parasite killing, dampness removing to stop itchin; Take hemostasis antidiarrheal orally, dispel wind-phlegm, external treatment is for eczema, scabies, Ting discharging ear; Take orally for incessant chronic diarrhea, have blood in stool, metrorrhagia, epilepsy go mad.Plumbum preparatium property is pungent, salty, cold, poisonous, enters the heart, spleen, Liver Channel, and removing toxic substances, granulation promoting, eliminating phlegm down to arrest convulsion control that carbuncle, ulcer, incised wound are hemorrhage, aphtha, corneal nebula, soup fire are burnt, infantile convulsion is demented, malaria, dysentery, tell converse stomach.Concha Ostreae property is salty, be slightly cold, and returns liver, gallbladder, kidney channel.Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, for the insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Cera Flava sweet in the mouth, light, property are flat, return spleen, stomach, large intestine channel, removing toxic substances, granulation promoting, dysentery relieving, hemostasis, analgesic therapy, main carbuncle carbuncle on the back, ulcer for holding back, urgency is pained, dysentery pus and blood, incessant chronic diarrhea, vaginal bleeding due to excessive movement of fetus, seminal emission, leukorrhagia.Galla Chinensis, Alumen and Cera Flava compatibility relieving diarrhea with astringents, removing dampness sore; Concha Ostreae not only can be restrained astringent or styptic treatment for spontaneous sweating but also can be calmed the nerves; Be aided with the effect of Plumbum preparatium and Cera Flava removing toxic substances and promoting granulation.Chinese medicine preparation of the present invention can be by the dry symptom that cures mainly diarrhoea of letting out.
Chinese medicine of the present invention is as follows for clinical situation: be the infant of accepting for medical treatment 7～October in 2010, and totally 31 examples, 2～3 years old age.Clinical manifestation is to defecate every day 3～10 times, defecates thin or as water sample, and yellow or yellow green, be mixed with a small amount of mucus milk lobe or indigestion food has mild dehydration more, can accompany the diseases such as abdominal distention stomachache, heating, the course of disease≤2 day.The pill that uses the embodiment of the present invention 2 to prepare, child takes 5-7 ball every day, and adult's ball every days 10 is limited, and every day twice, boiled water takes.Treat heating person's symptomatic treatment 7.
Diagnosis basis: according to the regulation of " People's Republic of China's Chinese medicine industry standard---traditional Chinese medical science disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis of having loose bowels ", defecate thin or as water sample, increased frequency; Can accompany the diseases such as abdominal distention stomachache; Acute sudden attack of spouting diarrhea onset is unexpected, and the course of disease is short; Can be with the disease such as aversion to cold, heating; Chronic chronic diarrhea onset is slow, and the course of disease is longer, outbreak repeatedly, time heavy when light; Improper diet, can bring out by cold and cool or emotion changes; Visible a little red, the leukocyte of stool routine examination, stool is cultivated pathogenic bacterium positive or negative; Make if desired x-ray barium enema or intestinal fiberscopy.
Effect assessment: according to the regulation of " People's Republic of China's Chinese medicine industry standard---traditional Chinese medical science disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis, syndrome-classification, the efficacy evaluation of having loose bowels ", cure: stool is normal, other transference cures, Clinical Laboratory is normal; Take a turn for the better: times of defecation obviously reduces, other symptoms are improved; Do not heal: symptom has no improvement.
Therapeutic Method: get 50 parts of Galla Chinensiss, 15 parts of Alumens, 10 parts of Plumbum preparatiums, 15 parts of Concha Ostreaes, 50 parts, Cera Flava.After Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae mix, be crushed to fine-powdered, cross 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make the heavily pill for 5g.Child takes 5-7 ball every day, and adult's ball every days 10 is limited; Every day twice, boiled water takes.Treat heating person's symptomatic treatment 7.
Therapeutic outcome: healing person's 21 examples account for 67.74%, improvement person's 9 examples account for 29.03%, and more person's 1 example does not account for 3.23%, and total effective rate reaches 96.77%.Use other embodiments of the invention and the therapeutic effect there was no significant difference that uses the embodiment of the present invention 2.
Model case:
1. Wang, female, 2 years old 4 months, in August, 2010 was medical, and nearly two week every day, watery stool several, without stomachache, had no temperature.Anus has burning sensation after an action of the bowels.Examine as diarrhoea, take the embodiment of the present invention 2 medicines, sooner or later respectively take medicine 1 time, each 3 balls, stool is normal afterwards to treat 7, described transference cure.
2. Zhao, man, 3 years old 2 months, 2010 were medical, and have loose bowels five or six nearly three week every day, abdominal distention stomachache, low grade fever occurs together.Examine as diarrhoea, take the embodiment of the present invention 2 medicines, sooner or later respectively take medicine 1 time, each 3 balls, treat and observe afterwards for 7th, and stool is normal, described transference cure.
3. Shen, female, 18 years old, diarrhoea again and again existing 1 year half, can not be in generally, the time is many easily to be occurred in the time of school, and all in the afternoon about 3,4 o'clock, belly pain, time have borborygmus, in time, lets out when half congealed, takes medicine and takes effect, but end-of-dose failure.Examine as diarrhoea, take the embodiment of the present invention 2 medicines, every day twice, each 5 balls are limited, and boiled water takes, and treat and observe afterwards for 7th, and all diseases alleviate, and stool was normal afterwards on 7th for continual cure, and described transference cure, follows up a case by regular visits to so far not recurrence.
Detailed description of the invention
Below in conjunction with experimental example and embodiment, the present invention is described in further detail.
Experimental example: to the Observation of Inhibition Effects of vibrio parahaemolytious propagation
Vibrio antibacterial (Vibrio spp) belongs to vibrionaceae, be a class Gram-negative, tool polar flagella, can move, asporous rod-short antibacterial, be to cause alimentary toxicosis common pathogen.Select vibrio antibacterial vibrio parahaemolytious to observe the inhibitory action of Chinese medicine preparation of the present invention to its propagation.
1, the preparation of Chinese medicinal liquor of the present invention: get described in embodiment 2 10 of pills, again grind to form powdery, water 10ml soaked overnight, filters, and filtrate decompression is concentrated, obtains dry powder, weighs; Use again water dissolution, adopt coubling dilution to prepare that concentration is respectively 6.25,12.5,25,50, the solution of 100mg/ml.
2, the preparation of LB fluid medium: get peptone 0.5g, yeast extract 0.1g, ferric ammonium citrate 0.01g, physiological saline solution 90ml, be uniformly mixed, regulate pH to 7.6, be settled to 100ml, conventional autoclave sterilization, is LB fluid medium.
3, the preparation of LB agar plate: LB fluid medium is micro-slowly adds 2g agar powder under boiling while stirring.Regulate pH value to 7.6, the paved LB agar plate of routine operation with the NaOH of 0.1mol/L while hot.
4, the preparation of bacterial strain: vibrio parahaemolytious is provided by preclinical medicine institute of Mountain Western Medicine S University, is stored in self-control medium slant, is put in 4 DEG C of refrigerators for subsequent use; By strain inoculate streak culture after, select colonies typical and be inoculated in LB fluid medium, cultivate 18-24h for 28 DEG C, after continuous passage 3 times, be 10 by the dilution of bacterium liquid
8individual/ml is for subsequent use.
5, dull and stereotyped hole method bacteriostatic test: get bacterium liquid 200ul routine on superclean bench and coat LB agar plate surface; Turn on LB agar plate and equidistantly make a call to 5 holes with ophthalmic cornea ring, aperture, every hole is 6.5mm, and lancet is chosen hole agar; In hole, drip respectively the Chinese medicinal liquor 0.15ml of the present invention of variable concentrations; Plate is placed in 28 DEG C of constant incubators and cultivates 48h; Measure antibacterial circle diameter with slide gauge.
6. experimental result: result shows, concentration is respectively 6.25,12.5,25,50, the Chinese medicine preparation of the present invention of 100mg/ml all can form larger inhibition zone, with matched group comparison, P value is all less than 0.01, illustrate that Chinese medicine preparation of the present invention has the effect that suppresses vibrio parahaemolytious propagation, the results are shown in Table 1.
Table 1: the inhibitory action of Chinese medicine preparation of the present invention to vibrio parahaemolytious propagation
Embodiment 1: a kind of Chinese medicine preparation for the treatment of diarrhoea, made by the raw material of following weight portion: 25 parts of Galla Chinensiss, 10 parts of Alumens, 5 parts of Plumbum preparatiums, 10 parts of Concha Ostreaes, 25 parts, Cera Flava.Described medicine Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae are crushed to fine-powdered after mixing, and cross 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make the heavily pill for 5g.The present embodiment institute pharmacy, adopts above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, and 34 patients are treated, therapeutic outcome: healing person's 21 examples account for 61.76%, improvement person's 10 examples account for 29.41%, and more person's 3 examples do not account for 8.82%, and total effective rate reaches 91.12%.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of diarrhoea, made by the raw material of following weight portion: 50 parts of Galla Chinensiss, 15 parts of Alumens, 10 parts of Plumbum preparatiums, 15 parts of Concha Ostreaes, 50 parts, Cera Flava.Described medicine Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae are crushed to fine-powdered after mixing, and cross 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make the heavily pill for 5g.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of diarrhoea, made by the raw material of following weight portion: 75 parts of Galla Chinensiss, 12 parts of Alumens, 8 parts of Plumbum preparatiums, 12 parts of Concha Ostreaes, 40 parts, Cera Flava.Described medicine Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae are crushed to fine-powdered after mixing, and cross 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make the heavily pill for 5g.The present embodiment institute pharmacy, adopts above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, and 30 patients are treated, therapeutic outcome: healing person's 19 examples account for 63.33%, improvement person's 9 examples account for 30%, and more person's 2 examples do not account for 6.67%, and total effective rate reaches 93.33%.
Embodiment 4: a kind of Chinese medicine preparation for the treatment of diarrhoea, made by the raw material of following weight portion: 60 parts of Galla Chinensiss, 10 parts of Alumens, 15 parts of Plumbum preparatiums, 15 parts of Concha Ostreaes, 80 parts, Cera Flava.Described medicine Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae are crushed to fine-powdered after mixing, and cross 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make the heavily pill for 5g.The present embodiment institute pharmacy, adopts above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, and 28 patients are treated, therapeutic outcome: healing person's 18 examples account for 64.29%, improvement person's 8 examples account for 28.57%, and more person's 2 examples do not account for 7.14%, and total effective rate reaches 92.86%.
Embodiment 5: a kind of Chinese medicine preparation for the treatment of diarrhoea, made by the raw material of following weight portion: 100 parts of Galla Chinensiss, 20 parts of Alumens, 15 parts of Plumbum preparatiums, 20 parts of Concha Ostreaes, 100 parts, Cera Flava.Described medicine Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae are crushed to fine-powdered after mixing, and cross 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make the heavily pill for 5g.The present embodiment institute pharmacy, adopts above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, and 24 patients are treated, therapeutic outcome: healing person's 15 examples account for 62.5%, improvement person's 7 examples account for 29.17%, and more person's 2 examples do not account for 8.33%, and total effective rate reaches 91.67%.
Claims (4)
1. a Chinese medicine preparation for the treatment of diarrhoea, is characterized in that: the raw material by following weight portion is made: Galla Chinensis 25-100 part, Alumen 10-20 part, Plumbum preparatium 5-15 part, Concha Ostreae 10-20 part, Cera Flava 25-100 part.
2. a kind of Chinese medicine preparation for the treatment of diarrhoea according to claim 1, is characterized in that: the raw material by following weight portion is made: 50 parts of Galla Chinensiss, 15 parts of Alumens, 10 parts of Plumbum preparatiums, 15 parts of Concha Ostreaes, 50 parts, Cera Flava.
3. a kind of Chinese medicine preparation for the treatment of diarrhoea according to claim 1 and 2, is characterized in that: described medicine Galla Chinensis, Alumen, Plumbum preparatium, Concha Ostreae are crushed to fine-powdered after mixing, and crosses 80-100 mesh sieve; Cera Flava heats and remains within the scope of 60-70 DEG C, adds medicated powder to stir; Get mixture and make pill.
4. a kind of Chinese medicine preparation for the treatment of diarrhoea according to claim 3, is characterized in that: pill is heavily 5g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210521363.0A CN103006710B (en) | 2012-12-07 | 2012-12-07 | Chinese medicinal preparation for treating diarrhea |
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| CN201210521363.0A CN103006710B (en) | 2012-12-07 | 2012-12-07 | Chinese medicinal preparation for treating diarrhea |
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| CN103006710B true CN103006710B (en) | 2014-10-22 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105055940A (en) * | 2015-07-29 | 2015-11-18 | 王志军 | Drug for treating diarrhea and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1293060A (en) * | 1999-10-19 | 2001-05-02 | 赵世海 | Chinese medicine for treating baby diarrhea and its preparing process |
| CN1765398A (en) * | 2004-10-28 | 2006-05-03 | 金恭春 | Chinese medicinal pill for treating damp heat pattern protracted diarrhea |
| CN1772150A (en) * | 2005-11-13 | 2006-05-17 | 李殿克 | Medicine for treating mastoproliferation and mastitis and its prepn |
| CN1911427A (en) * | 2005-09-05 | 2007-02-14 | 天津中新药业集团股份有限公司达仁堂制药厂 | Medicine for treating chronic diarrhoea |
-
2012
- 2012-12-07 CN CN201210521363.0A patent/CN103006710B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1293060A (en) * | 1999-10-19 | 2001-05-02 | 赵世海 | Chinese medicine for treating baby diarrhea and its preparing process |
| CN1765398A (en) * | 2004-10-28 | 2006-05-03 | 金恭春 | Chinese medicinal pill for treating damp heat pattern protracted diarrhea |
| CN1911427A (en) * | 2005-09-05 | 2007-02-14 | 天津中新药业集团股份有限公司达仁堂制药厂 | Medicine for treating chronic diarrhoea |
| CN1772150A (en) * | 2005-11-13 | 2006-05-17 | 李殿克 | Medicine for treating mastoproliferation and mastitis and its prepn |
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