CN104435206A - Pharmaceutical composition containing chicken's gizzard-membrane for treating diarrhea - Google Patents

Pharmaceutical composition containing chicken's gizzard-membrane for treating diarrhea Download PDF

Info

Publication number
CN104435206A
CN104435206A CN201410636125.3A CN201410636125A CN104435206A CN 104435206 A CN104435206 A CN 104435206A CN 201410636125 A CN201410636125 A CN 201410636125A CN 104435206 A CN104435206 A CN 104435206A
Authority
CN
China
Prior art keywords
parts
pharmaceutical composition
polygoni multiflori
raw material
endothelium corneum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410636125.3A
Other languages
Chinese (zh)
Inventor
骆均勇
张玲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHENGDU GUORUI PHARMACEUTICAL TECHNOLOGY Co Ltd
Original Assignee
CHENGDU GUORUI PHARMACEUTICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHENGDU GUORUI PHARMACEUTICAL TECHNOLOGY Co Ltd filed Critical CHENGDU GUORUI PHARMACEUTICAL TECHNOLOGY Co Ltd
Priority to CN201410636125.3A priority Critical patent/CN104435206A/en
Publication of CN104435206A publication Critical patent/CN104435206A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a pharmaceutical composition containing chicken's gizzard-membrane for treating diarrhea, which is prepared by taking chicken's gizzard-membrane, greater celandine herb, tuber fleeceflower root, hawthorn fruits, kudzuvine root, tuber fleeceflower stem and hericium erinaceus as raw materials. The pharmaceutical composition disclosed by the invention has the effects of regulating qi and strengthening the spleen, benefiting the stomach and nourishing the kidneys, clearing heat and drying dampness, promoting blood circulation and invigorating yang, as well as regulating qi and removing qi stagnation, has a significant curative effect on treatment of diarrhea, is small in administration dosage, and has no toxic or side effects to a human body; and furthermore, the prescription is simple, so that the pharmaceutical composition is conductive to popularization and application.

Description

The pharmaceutical composition being used for the treatment of diarrhoea containing Endothelium Corneum Gigeriae Galli
Technical field
The present invention relates to a kind of pharmaceutical composition being used for the treatment of diarrhoea, in particular to a kind of pharmaceutical composition being used for the treatment of diarrhoea containing Endothelium Corneum Gigeriae Galli, being specifically related to a kind of is the pharmaceutical composition that raw material is made by Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers..
Background technology
Diarrhoea, the traditional Chinese medical science is called has loose bowels, and is a kind of common sympton, and refer to that defecation frequency is significantly more than the frequency be on ordinary days accustomed to, excrement matter is thin, and moisture increases, and every day, feces volume was more than 200g, or containing non-digest food or pus and blood, mucus.Diarrhoea is normal with symptoms such as defecation urgency sense, anus discomfort, incontinences.Diarrhoea point acute and chronic two classes.Modern medicine belongs to digestive system disease diarrhoea, and clinical commonly have inflammatory bowel, functional gastrointestinal disorder and chronic diarrhea, as: acute gastroenteritis, functional dyspepsia, irritable bowel syndrome etc.Treatment mainly adopts antibiotic medicine, sulfa drugs, aid digestion medicine etc.Take western medicine diarrhoea and easily produce drug resistance, easily there is dysbacteriosis in prolonged and repeated use antibiotic, nonresponder can form chronic diarrhea and the clinical gastrointestinal dysfunction syndrome seen, and medical expense is high.
Therefore, how to develop a kind of rapid-action, short treating period, cost are low and the treatment that side effect is little diarrhoea medicine, be unanimously the unremitting pursue of medicine worker.
Summary of the invention
The object of the invention is to overcome above-mentioned deficiency existing in prior art, a kind of pharmaceutical composition being used for the treatment of diarrhoea containing Endothelium Corneum Gigeriae Galli is provided.This pharmaceutical composition has regulating qi-flowing for strengthening spleen, stomach reinforcing the kidney invigorating, heat clearing and damp drying, effect that is supporing yang, circulation of qi promoting removing food stagnancy of invigorating blood circulation, and its treatment diarrhoea is evident in efficacy, and dosage is little, and to human non-toxic's side effect, and prescription is simple, is beneficial to and applies.
In order to realize foregoing invention object, the invention provides following technical scheme:
The pharmaceutical composition being used for the treatment of diarrhoea containing Endothelium Corneum Gigeriae Galli of the present invention, it is the medicament be made up of following raw material: Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers..
In pharmaceutical composition of the present invention, Endothelium Corneum Gigeriae Galli is sweet, flat.Return spleen, stomach, small intestinal, urinary bladder channel.Invigorating the stomach and promoting digestion, controlling nocturnal emission with astringent drugs is only lost.Cure mainly accumulation of food in the stomach and intes tine due to indigestion, infantile malnutrition, the enuresis is passed out semen, stranguria caused by urinary stone.
Herba Chelidonii, cool in nature, bitter in the mouth.Return lung; The heart; Kidney channel." the conventional Chinese herbal medicine in the north ": have analgesia, cough-relieving, sterilization, diuresis, separate the merit of sore.Treating acute and chronic gastritis, gastric ulcer, stomachache, dysentery, cough, cirrhotic ascites.
Radix Polygoni Multiflori, bitter sweet puckery, tepor.Enter liver, kidney channel.Nourishing the blood and yin; Loosening bowel to relieve constipation; Preventing the attack (or recurrence) of malaria; Dispel the wind; Removing toxic substances.Main blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula; Hemorrhoid.
Fructus Crataegi, acid is sweet, tepor.Enter spleen, stomach, Liver Channel.Help digestion long-pending, dissipating blood stasis blood, expelling tenia.Control meat to amass, lump in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia after-pains in puerperal, lochiorrhea, children's's breast food is stagnated.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia.
Radix Puerariae, sweet, pungent, cool.Attach to the lung and stomach meridians.Relieving muscles diaphoresis, rash, yang invigorating antidiarrheal, promoting the production of body fluid to quench thirst.For fever caused by exogenous pathogens, stiff nape and back, measles without adequate eruption, damp-heat dysentery, diarrhea due to hypofunction of the spleen, calentura excessive thirst, diabete.
Caulis Polygoni Multiflori, sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel.There is effect of energy tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral.Cure mainly insomnia and dreamful sleep, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, wind skin ulcer scabies.
Hericium erinaceus (Bull. Ex Fr.) Pers., property is put down, sweet in the mouth; Return spleen, stomach warp.There is stomach invigorating, tonify deficiency, anticancer, effect of kidney tonifying essence.
Applicant finds through test of many times, is that pharmaceutical composition made by raw material, effectively can treats diarrhoea by Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers..
Preferably, described pharmaceutical composition is made up of the raw material of following weight: Endothelium Corneum Gigeriae Galli 5 ~ 16 parts, Herba Chelidonii 8 ~ 25 parts, Radix Polygoni Multiflori 5 ~ 14 parts, Fructus Crataegi 3 ~ 12 parts, Radix Puerariae 3 ~ 12 parts, Caulis Polygoni Multiflori 1 ~ 7 part and Hericium erinaceus (Bull. Ex Fr.) Pers. 1 ~ 7 part.
Applicant finds through many experiments, and pharmaceutical composition of the present invention is made up of the raw material of above-mentioned weight, better can play the synergistic function of each raw material components, not only effectively can treat diarrhoea, instant effect simultaneously, dosage is little, has no side effect.
Further preferably, described pharmaceutical composition is made up of the raw material of following weight: Endothelium Corneum Gigeriae Galli 6 ~ 12 parts, Herba Chelidonii 10 ~ 20 parts, Radix Polygoni Multiflori 6 ~ 12 parts, Fructus Crataegi 4 ~ 10 parts, Radix Puerariae 4 ~ 8 parts, Caulis Polygoni Multiflori 1 ~ 5 part and Hericium erinaceus (Bull. Ex Fr.) Pers. 1 ~ 5 part.
Still more preferably, described pharmaceutical composition is made up of the raw material of following weight: Endothelium Corneum Gigeriae Galli 8 ~ 10 parts, Herba Chelidonii 12 ~ 15 parts, Radix Polygoni Multiflori 8 ~ 10 parts, Fructus Crataegi 5 ~ 9 parts, Radix Puerariae 5 ~ 7 parts, Caulis Polygoni Multiflori 2 ~ 4 parts and Hericium erinaceus (Bull. Ex Fr.) Pers. 1 ~ 3 part.
Preferably, to the best described pharmaceutical composition be made up of the raw material of following weight: Endothelium Corneum Gigeriae Galli 9 parts, Herba Chelidonii 12 parts, Radix Polygoni Multiflori 9 parts, Fructus Crataegi 6 parts, Radix Puerariae 6 parts, Caulis Polygoni Multiflori 3 parts and Hericium erinaceus (Bull. Ex Fr.) Pers. 3 parts.
By preferably above, the curative effect of pharmaceutical composition can be improved further.
The dosage form of pharmaceutical composition of the present invention can be the existing pharmaceutical dosage form of any one in drop pill, tablet, capsule, soft capsule, powder, oral liquid, granule.
The preparation method of pharmaceutical composition of the present invention is as follows:
(1) by Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers. mix homogeneously, add 80% ethanol of raw material gross weight 3 ~ 5 times of weight, reflux, extract, 2 ~ 4h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 8 ~ 10 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, make acceptable various pharmaceutical dosage form.
According to the needs of the various drug form of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
Preparation method of the present invention effectively can extract the effective ingredient in each crude drug, makes it better play the effect of Synergistic.
The present invention's various raw medicinal materials used are the Chinese crude drug meeting country or provincial standard and specify.The pharmaceutical composition for the treatment of diarrhoea of the present invention, based on theory of Chinese medical science, in conjunction with clinical practice, from Chinese medicine material treasure-house, filter out Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and the pure purification of tcm of Hericium erinaceus (Bull. Ex Fr.) Pers. seven taste form, and regulate the weight of each raw material, make the effect playing Synergistic between each raw material, effectively can treat diarrhoea, regulating qi-flowing for strengthening spleen, stomach reinforcing the kidney invigorating, heat clearing and damp drying, supporing yang, circulation of qi promoting removing food stagnancy of invigorating blood circulation.Pharmaceutical composition instant effect of the present invention simultaneously, dosage is little, has no side effect.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
The pharmaceutical composition of the treatment diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Endothelium Corneum Gigeriae Galli 9g, Herba Chelidonii 12g, Radix Polygoni Multiflori 9g, Fructus Crataegi 6g, Radix Puerariae 6g, Caulis Polygoni Multiflori 3g and Hericium erinaceus (Bull. Ex Fr.) Pers. 3g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
(1) by Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers. mix homogeneously, add 80% ethanol of raw material gross weight 3 times of weight, reflux, extract, 3h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 10 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, then add 60g calcium carbonate, 10g starch, adopt wet-mixed to granulate, after particle drying, adopt No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 2
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Endothelium Corneum Gigeriae Galli 5g, Herba Chelidonii 25g, Radix Polygoni Multiflori 10g, Fructus Crataegi 3g, Radix Puerariae 3g, Caulis Polygoni Multiflori 7g and Hericium erinaceus (Bull. Ex Fr.) Pers. 7g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
(1) by Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers. mix homogeneously, add 80% ethanol of raw material gross weight 5 times of weight, reflux, extract, 2h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 9 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, then add 50g calcium carbonate, 10g starch, adopt wet-mixed to granulate, after particle drying, adopt No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 3
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Endothelium Corneum Gigeriae Galli 16g, Herba Chelidonii 8g, Radix Polygoni Multiflori 14g, Fructus Crataegi 12g, Radix Puerariae 12g, Caulis Polygoni Multiflori 1g and Hericium erinaceus (Bull. Ex Fr.) Pers. 2g.
Above-mentioned raw materials is prepared into capsule, and preparation method is as follows:
(1) by Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers. mix homogeneously, add 80% ethanol of raw material gross weight 4 times of weight, reflux, extract, 4h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 8 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, then add 60g calcium carbonate, 15g starch, adopt wet-mixed to granulate, after particle drying, adopt No. 1 capsule, make capsule, every capsules Dissolve things inside weight is about 0.3g.
Embodiment 4
Treat the pharmaceutical composition of diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Endothelium Corneum Gigeriae Galli 10g, Herba Chelidonii 20g, Radix Polygoni Multiflori 5g, Fructus Crataegi 4g, Radix Puerariae 6g, Caulis Polygoni Multiflori 2g and Hericium erinaceus (Bull. Ex Fr.) Pers. 7g.
Above-mentioned raw materials is prepared into granule, and preparation method is as follows:
(1) by Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers. mix homogeneously, add 80% ethanol of raw material gross weight 3 times of weight, reflux, extract, 3h, filter, recovery ethanol, obtains concentrated solution and medicinal residues are retained for subsequent use respectively;
(2) medicinal residues are added the water of 10 times of weight, decoct, decocting time 1.5h, it is for subsequent use that separation obtains decoction liquor, and medicinal residues are abandoned;
(3) concentrated solution and decoction liquor are merged, concentrated, dry, mix with 100g dextrin, adopt the preparation technique of existing granule, make the pharmaceutical composition of granule.
Comparative example 1
The pharmaceutical composition of the treatment diarrhoea described in this comparative example, be made up of the raw material of following weight:
Herba Chelidonii 12g, Radix Polygoni Multiflori 9g, Fructus Crataegi 6g, Radix Puerariae 6g, Caulis Polygoni Multiflori 3g and Hericium erinaceus (Bull. Ex Fr.) Pers. 3g.
Adopt the preparation method described in embodiment 1, make the pharmaceutical composition of capsule.
Comparative example 2
The pharmaceutical composition of the treatment diarrhoea described in the present embodiment, be made up of the raw material of following weight:
Endothelium Corneum Gigeriae Galli 9g, Radix Polygoni Multiflori 9g, Fructus Crataegi 6g, Radix Puerariae 6g, Caulis Polygoni Multiflori 3g and Hericium erinaceus (Bull. Ex Fr.) Pers. 3g.
Adopt the preparation method described in embodiment 1, make the pharmaceutical composition of capsule.
Embodiment 5
1. the Observation of Inhibition Effects of pair vibrio parahaemolytious propagation
Vibrio bacteria (Vibrio spp) belongs to vibrionaceae, be a class Gram-negative, tool polar flagella, can move, asporous rod-short antibacterial, be cause alimentary toxicosis common pathogen.The inhibitory action selecting vibrio bacteria vibrio parahaemolytious to observe pharmaceutical composition of the present invention to breed it.
The preparation of 1.1 Chinese medicinal liquors of the present invention: the pharmaceutical composition of capsule described in Example 1, pours out Dissolve things inside, spends the night with the water soaking of 10 times of weight, and filter, filtrate reduced in volume, obtains dry powder, weighs; Use water dissolution again, adopt coubling dilution prepare concentration be respectively 6,12,30,50, the solution of 100mg/ml.
The preparation of 1.2LB fluid medium: get peptone 0.5g, yeast extract 0.1g, ferric ammonium citrate 0.01g, physiological saline solution 90ml, be uniformly mixed, regulates pH to 7.6, is settled to 100ml, and conventional high-pressure is sterilized, and is LB fluid medium.
The preparation of 1.3LB agar plate: LB fluid medium is micro-boil under slowly add 2g agar powder while stirring.Use the NaOH adjust ph of 0.1mol/L to 7.6 while hot, the paved LB agar plate of routine operation.
The preparation of 1.4 bacterial strains: vibrio parahaemolytious is provided by preclinical medicine institute of Mountain Western Medicine S University, is stored in self-made medium inclined-plane, is put in 4 DEG C of refrigerators for subsequent use; After strain inoculation is streak culture, select colonies typical and be inoculated in LB fluid medium, cultivate 18-24h for 28 DEG C, is 10 by the dilution of bacterium liquid after continuous passage 3 times 8individual/ml is for subsequent use.
1.5 dull and stereotyped hole method bacteriostatic tests: get bacterium liquid 200 μ l routine on superclean bench and coat LB agar plate surface; Turn with ophthalmic cornea ring and equidistantly make a call to 5 holes on LB agar plate, aperture, every hole is 6.5mm, and hole agar chosen by lancet; The Chinese medicinal liquor 0.15ml of the present invention of variable concentrations is dripped respectively in hole; Plate is placed in 28 DEG C of constant incubators and cultivates 48h; Antibacterial circle diameter is measured with slide gauge.
1.6 experimental results: result shows, concentration is respectively 6,12,30,50, the pharmaceutical composition of the present invention of 100mg/ml all can form larger inhibition zone, compare with matched group, P value is all less than 0.01, illustrate that pharmaceutical composition of the present invention has the effect suppressing vibrio parahaemolytious propagation, the results are shown in Table 1.
Table 1: the inhibitory action that pharmaceutical composition of the present invention is bred vibrio parahaemolytious
Note: compare with matched group, *p < 0.01.
2. clinical trial
2.1 diagnosis basis: according to the regulation of " People's Republic of China's traditional Chinese medicine industry standard---Chinese medical disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis of having loose bowels ", soft stools or as water sample, increased frequency; The diseases such as abdominal distention stomachache can be accompanied; Acute sudden attack of spouting diarrhea onset is unexpected, and the course of disease is short; Can with the disease such as aversion to cold, heating; Chronic chronic diarrhea onset is slow, and the course of disease is longer, recurrent exerbation, time light time heavy; Improper diet, can to bring out by cold and cool or emotion changes; Visible red, the leukocyte a little of stool routine examination, stool cultivates pathogenic bacterium positive or negative; Make x-ray barium enema or intestinal fiberscopy if desired.
2.2 general data: pharmaceutical composition of the present invention is used for clinical observation case 150 example, is divided at random five groups (experimental group 1 ~ 3 and matched groups 1 ~ 3), often organizes 30 people.
Experimental group 1:30 example, man 16 example, female 14 example, the age is 9 ~ 58 years old, average 24 years old.All meet above-mentioned diagnosis basis.
Experimental group 2:30 example, man 15 example, female 15 example, the age is 9 ~ 64 years old, average 23 years old.All meet above-mentioned diagnosis basis.
Experimental group 3:30 example, man 14 example, female 16 example, the age is 8 ~ 57 years old, average 21 years old.All meet above-mentioned diagnosis basis.
Matched group 1:30 example, man 15 example, female 15 example, the age is 9 ~ 66 years old, average 24 years old.All meet above-mentioned diagnosis basis.
Matched group 2:30 example, man 15 example, female 15 example, the age is 10 ~ 68 years old, average 25 years old.All meet above-mentioned diagnosis basis.
Above five groups of physical data comparing differences are without significantly.
2.3 therapeutic evaluatioies: according to the regulation of " People's Republic of China's traditional Chinese medicine industry standard---Chinese medical disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis of having loose bowels, syndrome-classification, efficacy evaluation ", cure: stool is normal, other transference cures, Clinical Laboratory is normal; Take a turn for the better: times of defecation obviously reduces, other symptoms are improved; Do not heal: symptom has no improvement.
2.4 medications:
Experimental group 1: take pharmaceutical composition prepared by the embodiment of the present invention 1, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Experimental group 2: take pharmaceutical composition prepared by the embodiment of the present invention 2, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Experimental group 3: take pharmaceutical composition prepared by the embodiment of the present invention 3, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Matched group 1: the pharmaceutical composition taking comparative example 1 of the present invention preparation, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
Matched group 2: the pharmaceutical composition taking comparative example 2 of the present invention preparation, adult daily 3 times, each 2, boiled water is taken after mixing it with water, and child reduces by half.Treat 7, heating person's symptomatic treatment.
2.5 therapeutic outcome
The therapeutic outcome of each group of patient is as shown in table 2.
The therapeutic outcome of patient respectively organized by table 2.
Note: cure rate=healing number of cases ÷ tests number of cases × 100%; Total effective rate=(curing number of cases+improvement number of cases) ÷ tests number of cases × 100%.
In experimentation, all do not find untoward reaction before and after most of patient medication of experimental group 1 ~ 3 and matched group 1 ~ 2, only have 1 ~ 4 routine patient to occur the discomforts such as dizzy, by the equal spontaneous remission of diet modification, non-drug withdrawal, shows that pharmaceutical composition of the present invention has no side effect to patient body.
The cure rate of experimental group in table 21 ~ 3 with comparative example 1 ~ 2 is compared with total effective rate, the cure rate of experimental group and total effective rate improve about 30%, about 20% respectively, show that pharmaceutical composition of the present invention needs the mutual compatibility of each raw material components, play the effect of Synergistic, just can reach best therapeutic effect, lack the curative effect that any Herba indigoferae Pseudotinctoriae all significantly can reduce pharmaceutical composition.
Compared with total effective rate by the cure rate of experimental group in table 21 ~ 3, the cure rate of experimental group 1 and total effective rate comparatively experimental group 2 improve 16%, 3% respectively, and comparatively experimental group 3 improves 20% respectively, and 0%; Showing that the pharmaceutical composition described in embodiment 1 achieves non-obvious effect, is optimum implementation of the present invention.

Claims (5)

1. the pharmaceutical composition being used for the treatment of diarrhoea containing Endothelium Corneum Gigeriae Galli, it is characterized in that, it is the medicament be made up of following raw material: Endothelium Corneum Gigeriae Galli, Herba Chelidonii, Radix Polygoni Multiflori, Fructus Crataegi, Radix Puerariae, Caulis Polygoni Multiflori and Hericium erinaceus (Bull. Ex Fr.) Pers..
2. pharmaceutical composition according to claim 1, it is characterized in that, the weight of described each raw material is: Endothelium Corneum Gigeriae Galli 5 ~ 16 parts, Herba Chelidonii 8 ~ 25 parts, Radix Polygoni Multiflori 5 ~ 14 parts, Fructus Crataegi 3 ~ 12 parts, Radix Puerariae 3 ~ 12 parts, Caulis Polygoni Multiflori 1 ~ 7 part and Hericium erinaceus (Bull. Ex Fr.) Pers. 1 ~ 7 part.
3. pharmaceutical composition according to claim 2, it is characterized in that, the weight of described each raw material is: Endothelium Corneum Gigeriae Galli 6 ~ 12 parts, Herba Chelidonii 10 ~ 20 parts, Radix Polygoni Multiflori 6 ~ 12 parts, Fructus Crataegi 4 ~ 10 parts, Radix Puerariae 4 ~ 8 parts, Caulis Polygoni Multiflori 1 ~ 5 part and Hericium erinaceus (Bull. Ex Fr.) Pers. 1 ~ 5 part.
4. pharmaceutical composition according to claim 3, it is characterized in that, the weight of described each raw material is: Endothelium Corneum Gigeriae Galli 8 ~ 10 parts, Herba Chelidonii 12 ~ 15 parts, Radix Polygoni Multiflori 8 ~ 10 parts, Fructus Crataegi 5 ~ 9 parts, Radix Puerariae 5 ~ 7 parts, Caulis Polygoni Multiflori 2 ~ 4 parts and Hericium erinaceus (Bull. Ex Fr.) Pers. 1 ~ 3 part.
5. pharmaceutical composition according to claim 4, is characterized in that, the weight of described each raw material is: Endothelium Corneum Gigeriae Galli 9 parts, Herba Chelidonii 12 parts, Radix Polygoni Multiflori 9 parts, Fructus Crataegi 6 parts, Radix Puerariae 6 parts, Caulis Polygoni Multiflori 3 parts and Hericium erinaceus (Bull. Ex Fr.) Pers. 3 parts.
CN201410636125.3A 2014-11-11 2014-11-11 Pharmaceutical composition containing chicken's gizzard-membrane for treating diarrhea Pending CN104435206A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410636125.3A CN104435206A (en) 2014-11-11 2014-11-11 Pharmaceutical composition containing chicken's gizzard-membrane for treating diarrhea

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410636125.3A CN104435206A (en) 2014-11-11 2014-11-11 Pharmaceutical composition containing chicken's gizzard-membrane for treating diarrhea

Publications (1)

Publication Number Publication Date
CN104435206A true CN104435206A (en) 2015-03-25

Family

ID=52882468

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410636125.3A Pending CN104435206A (en) 2014-11-11 2014-11-11 Pharmaceutical composition containing chicken's gizzard-membrane for treating diarrhea

Country Status (1)

Country Link
CN (1) CN104435206A (en)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
潘成平等: "宁肠治泻汤治疗腹泻型肠易激综合征52例", 《实用中医内科杂志》 *
胡翰文等: "暴泻证治", 《山西中医》 *

Similar Documents

Publication Publication Date Title
CN102772781A (en) Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof
CN102188685B (en) Externally-applied traditional Chinese medicine powder for treating diarrhea type irritable bowel syndrome and preparation method thereof
CN104352920A (en) Digestion-helping and stomach-conditioning traditional Chinese medicinal composition
CN105535495A (en) Chinese medicinal composition for treating esophageal cancer by reinforcing vital essence and strengthening primordial qi and preparation method
CN104547936A (en) Traditional Chinese medicine for treating local induration of vascular access of hemodialysis patient
CN103784932A (en) Traditional Chinese medicine decoction for treating hyperplasia of mammary glands
CN102058808A (en) Traditional Chinese medicament for treating rheumatic arthritis
CN101129679A (en) Chinese medicine composition for treating constipation
CN104666702A (en) Traditional Chinese medicine composition for treating acute and chronic enteritis, colitis and bowel dysfunction
CN104367887A (en) Wild jujube seed-containing pharmaceutical composition for treating diarrhea
CN104435533A (en) Codonopsis-containing pharmaceutical composition for treating diarrhea
CN104906472A (en) Traditional Chinese medicine composition for preventing and treating cough-variant asthma
CN104383403A (en) Traditional Chinese medicinal composition for treating chronic gastritis
CN103948763A (en) Traditional Chinese medicinal composition for treating hepatosis
CN104435206A (en) Pharmaceutical composition containing chicken&#39;s gizzard-membrane for treating diarrhea
CN104435327A (en) Coptis-chinensis-containing pharmaceutical composition for treating diarrhea
CN104367654A (en) Raspberry-containing pharmaceutical composition for treating diarrhea
CN103816450B (en) A kind of Chinese medicine for the treatment of rheumatoid arthritis
CN104435975A (en) Tuckahoe-containing pharmaceutical composition for treating diarrhea
CN104435534A (en) Patchouli-containing pharmaceutical composition for treating diarrhea
CN104367671A (en) Radix sanguisorbae-containing pharmaceutical composition for treating diarrhea
CN105770821A (en) Medicine composition containing folium artemisiae argyi and used for treating functional dyspepsia
CN105477067A (en) Traditional Chinese medicine composition for treating dampness obstructing spleen-stomach type infantile jaundice
CN104398605A (en) Pericarpium granati-containing pharmaceutical composition for treating diarrhoea
CN104436108A (en) Tangerine-peel-containing pharmaceutical composition for treating diarrhea

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20150325