CN103800748A - Traditional Chinese medicinal composition for treating dyspepsia - Google Patents
Traditional Chinese medicinal composition for treating dyspepsia Download PDFInfo
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- CN103800748A CN103800748A CN201310671669.9A CN201310671669A CN103800748A CN 103800748 A CN103800748 A CN 103800748A CN 201310671669 A CN201310671669 A CN 201310671669A CN 103800748 A CN103800748 A CN 103800748A
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Abstract
The invention relates to the field of traditional Chinese medicinal compositions, and in particular relates to a traditional Chinese medicinal composition for treating dyspepsia. The composition comprises the following components: 15-25g of codonopsis pilosula, 10-20g of astragalus membranaceus, 13-18g of hawthorn, 15-20g of medicated leaven, 20-25g of fried malt, 10-20g of liquorice, 18-22g of dried tangerine peel, 8-12g of semen pharbitidis, 6-8g of rhizoma cyperi, 12-22g of poria, 5-10g of rheum officinale, 5-8g of tendril-leaved fritillary bulb, and 3-6g of apricot kernel. The traditional Chinese medicinal composition has the beneficial effects that the traditional Chinese medicinal composition and cisapride have a remarkable effect to promoting rat gastric emptying and intestinal operation, which indicates that the traditional Chinese medicinal composition has a remarkable effect for improving gastrointestinal dynamics, is low in toxic and side effects due to pure traditional Chinese medicines, can be used for improving muscle body capability by regulating muscle body, and is wide in application range.
Description
Technical field
The present invention relates to Chinese medicine composition field, more specifically one is treated dyspeptic Chinese medicine composition.
Background technology
Dyspepsia is by the caused disease of gastric motility disorder, also comprises gastroparesis and esophageal regurgitation disease that gastric peristalsis is bad.Dyspepsia is mainly divided into functional dyspepsia and Organic dyspepsia.Functional dyspepsia belongs to the categories such as the traditional Chinese medical science " gastral cavity painful abdominal mass ", " stomachache ", " noisy ", and its disease, at stomach, relates to the internal organs such as liver spleen, and suitable determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, gives invigorating the spleen and regulating the stomach, depressed liver-energy dispersing and QI regulating, the method treatments such as dyspepsia and intestinal stasis relieving.Cause that dyspeptic reason is a lot, comprise the chronic inflammatory disease at harmonization of the stomach duodenum position, make the normal creepage of gastrointestinal functions functional disorder of esophagus, Stomach duodenum.Patient's spirit unhappiness, long-term depressed or be subject to suddenly fierce stimulation etc. and all can cause.Gastroparesis is by due to diabetes, constitutional anorexia nervosa and gastrectomy.Gastrointestinal disease can cause dyspepsia, comprises the chronic inflammatory disease at harmonization of the stomach duodenum position, makes the normal creepage of gastrointestinal functions functional disorder of esophagus, Stomach duodenum.
The dyspeptic cause of disease and pathogenesis are still not exclusively clear, most scholars think that this disease is due to many factors, now generally acknowledged that its main pathogenesis is that gastrointestinal motility obstacle, gastric acid secretion are abnormal, internal organs perception allergy, and the effect of psychologic factors, dietary factor, helicobacter pylori infections and gut hormone etc. is still in exploration.The selection of functional dyspepsia Therapeutic Method is experimental, and there is no a kind of method or medicine has sure curative effect to all patients, also lacks objective reliable curative effect determinate standard.The basic principle for the treatment of is on the basis of doctor-patient relationship of setting up mutual trust, varies with each individual and takes individuation, complex treatment measure, and this is the deficiencies in the prior art.
Summary of the invention
Goal of the invention of the present invention is for deficiency of the prior art, provides a kind of applied widely, the dyspeptic Chinese medicine composition for the treatment of that therapeutic effect is good, and it adopts pure Chinese medicine, and safe without toxic side effect and Chinese medicine focus on conditioning, applied widely.
The present invention is achieved by the following technical solutions:
One is treated dyspeptic Chinese medicine composition, is made up of following component: Radix Codonopsis 15-25g, Radix Astragali 10-20g, Fructus Crataegi 13-18g, Massa Medicata Fermentata 15-20g, Fructus Hordei Germinatus (parched) 20-25g, Radix Glycyrrhizae 10-20g, Pericarpium Citri Reticulatae 18-22g, Semen Pharbitidis 8-12g, Rhizoma Cyperi 6-8g, Poria 12-22g, Radix Et Rhizoma Rhei 5-10g, Bulbus Fritillariae Cirrhosae 5-8g, Semen Armeniacae Amarum 3-6g.
Above-mentioned Chinese medicine composition is made up of following component: Radix Codonopsis 20g, Radix Astragali 18g, Fructus Crataegi 15g, Massa Medicata Fermentata 18g, Fructus Hordei Germinatus (parched) 22g, Radix Glycyrrhizae 15g, Pericarpium Citri Reticulatae 20g, Semen Pharbitidis 10g, Rhizoma Cyperi 6g, Poria 18g, Radix Et Rhizoma Rhei 6g, Bulbus Fritillariae Cirrhosae 8g, Semen Armeniacae Amarum 5g.
The dosage form of the dyspeptic Chinese medicine composition of above-mentioned treatment is granule, tablet, capsule, pill, powder or oral liquid.
The dosage form of the dyspeptic Chinese medicine composition of above-mentioned treatment is granule.
Above-mentioned one is treated dyspeptic Chinese medicine composition, and the preparation method of described granule comprises step:
(1) each component Chinese herbal medicine is shattered into coarse powder for subsequent use;
(2) get Pericarpium Citri Reticulatae coarse powder, vapor extraction volatile oil, after medicinal residues and distillation, water liquid is for subsequent use; Volatile oil cool drying is for subsequent use;
(3) take out and go Pericarpium Citri Reticulatae residue Chinese herbal medicine coarse powder to mix, decoct 3 times after soaking the medicinal residues that add after 1 hour in step (2) and water liquid, each decoction liquor is filtered to mix be condensed into cream, convergence is dry;
(4) cream is dried and shattered rear granulation, add volatile oil mix homogeneously subpackage.
The invention has the beneficial effects as follows: Chinese medicine composition of the present invention and fine sand Billy are to promoting rat stomach effect emptying and intestinal running very obvious, the have clear improvement effect of gastrointestinal motivity of Chinese medicine composition tool of the present invention is described, and as pure Chinese medicine product, toxic and side effects is low, by the adjusting of human body being improved to the ability of human body, applied widely.
The specific embodiment
Below in conjunction with specific embodiment, the present invention will be further described, so that those skilled in the art can better understand the present invention, but therefore do not limit the present invention.
Embodiment 1
Chinese medicine composition is made up of following component: Radix Codonopsis 20g, Radix Astragali 18g, Fructus Crataegi 15g, Massa Medicata Fermentata 18g, Fructus Hordei Germinatus (parched) 22g, Radix Glycyrrhizae 15g, Pericarpium Citri Reticulatae 20g, Semen Pharbitidis 10g, Rhizoma Cyperi 6g, Poria 18g, Radix Et Rhizoma Rhei 6g, Bulbus Fritillariae Cirrhosae 8g, Semen Armeniacae Amarum 5g.
Embodiment 2
Promote gastric motility experiment
Laboratory animal
Male rat, body weight 200 ± 10g, 25 ± 1 ℃ of test temperatures, humidity 60 ± 5%, light application time 12h, before experiment, fasting be can't help water 12 hours.
Experimental drug
Experimental agents; Granule in embodiment 1 deionized water dissolution filter, is configured to filtrate the experimental solutions of 200mg crude drug/ml with deionized water, 4 ℃ for subsequent use;
Blank: deionized water
Gastrointestinal internal labeling thing: glucosan sugar is blue-2000, is made into 2% solution with deionized water.
Test method
By 50 rats be divided at random 1-5 group, wherein 1 group give with 1.0g crude drug/kg Experimental agents, gastric infusion; Give and 0.5g crude drug/kg Experimental agents for 2 groups, gastric infusion, gives and 0.25g crude drug/kg Experimental agents for 3 groups, and gastric infusion is given and 10ml/kg fine sand Billy for 4 groups, and gastric infusion is given and deionized water 10ml/kg, gastric infusion for 5 groups.
After perfusion 30 minutes, pour into 2% glucosan sugar indigo plant-20000.4ml to each group of rat, after 20 minutes, de-rat neck is put to death, open abdomen and get full gastrointestinal, from sphincter of pylorus, stomach is got at place, cut off along large curved side, rinsing in 4ml deionized water, after centrifugal 15 minutes, get supernatant, in 721-A spectrophotometer, measure absorbance at absorbing wavelength 620nm place, this absorbance is the residual absorbance of gastric pigment, calculate that to obtain the gastric pigment of experimental group with respect to the percentage ratio of 5 class means relatively residual, measure simultaneously sphincter of pylorus to pigment foremost and to the distance of caecum, take the two ratio as intestinal propulsion rate.
Experimental result is picked up following table, respectively organizes large intestine digestive tract power and changes;
| Group | Rat number (only) | The relative residual rate of gastric pigment (%) | Intestinal propulsion rate |
| 1 | 10 | 36.23±7.34** | 78.65±4.36 |
| 2 | 10 | 39.12±7.83** | 75.524.18 |
| 3 | 10 | 45.43±5.47 | 63.29±5.59 |
| 4 | 10 | 30.69±7.24** | 79.383.34 |
| 5 | 10 | 100.00±16.35 | 56.498.46 |
With relatively * P < 0.05 of blank group, * * P < 0.01
Conclusion, as seen from the above table, Chinese medicine composition of the present invention and fine sand Billy are to promoting rat stomach effect emptying and intestinal running very obvious, the have clear improvement effect of gastrointestinal motivity of Chinese medicine composition tool of the present invention is described, and as pure Chinese medicine product, toxic and side effects is low, by the adjusting of human body being improved to the ability of human body, applied widely.
Claims (5)
1. the dyspeptic Chinese medicine composition for the treatment of, is made up of following component: Radix Codonopsis 15-25g, Radix Astragali 10-20g, Fructus Crataegi 13-18g, Massa Medicata Fermentata 15-20g, Fructus Hordei Germinatus (parched) 20-25g, Radix Glycyrrhizae 10-20g, Pericarpium Citri Reticulatae 18-22g, Semen Pharbitidis 8-12g, Rhizoma Cyperi 6-8g, Poria 12-22g, Radix Et Rhizoma Rhei 5-10g, Bulbus Fritillariae Cirrhosae 5-8g, Semen Armeniacae Amarum 3-6g.
2. one according to claim 1 is treated dyspeptic Chinese medicine composition, it is characterized in that: described Chinese medicine composition is made up of following component: Radix Codonopsis 20g, Radix Astragali 18g, Fructus Crataegi 15g, Massa Medicata Fermentata 18g, Fructus Hordei Germinatus (parched) 22g, Radix Glycyrrhizae 15g, Pericarpium Citri Reticulatae 20g, Semen Pharbitidis 10g, Rhizoma Cyperi 6g, Poria 18g, Radix Et Rhizoma Rhei 6g, Bulbus Fritillariae Cirrhosae 8g, Semen Armeniacae Amarum 5g.
3. one according to claim 1 is treated dyspeptic Chinese medicine composition, it is characterized in that: the dosage form of the dyspeptic Chinese medicine composition of described treatment is granule, tablet, capsule, pill, powder or oral liquid.
4. one according to claim 3 is treated dyspeptic Chinese medicine composition, it is characterized in that: the dosage form of the dyspeptic Chinese medicine composition of described treatment is granule.
5. one according to claim 4 is treated dyspeptic Chinese medicine composition, it is characterized in that: the preparation method of described granule comprises step:
(1) each component Chinese herbal medicine is shattered into coarse powder for subsequent use;
(2) get Pericarpium Citri Reticulatae coarse powder, vapor extraction volatile oil, after medicinal residues and distillation, water liquid is for subsequent use; Volatile oil cool drying is for subsequent use;
(3) take out and go Pericarpium Citri Reticulatae residue Chinese herbal medicine coarse powder to mix, decoct 3 times after soaking the medicinal residues that add after 1 hour in step (2) and water liquid, each decoction liquor is filtered to mix be condensed into cream, convergence is dry;
(4) cream is dried and shattered rear granulation, add volatile oil mix homogeneously subpackage.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104273529A (en) * | 2014-09-26 | 2015-01-14 | 上海浦东高星生物技术研究所 | Dragon fruit tablets |
| CN104491592A (en) * | 2014-11-26 | 2015-04-08 | 山东永泰化工有限公司 | Health-care tea used for functional dyspepsia |
| CN105233095A (en) * | 2015-11-06 | 2016-01-13 | 李宏 | Formula and administration method of traditional Chinese medicine for treating stomach troubles |
| CN106138584A (en) * | 2016-07-21 | 2016-11-23 | 魏晓兵 | A kind of Chinese medicine of external application for curing stomachache |
| CN106720988A (en) * | 2016-11-30 | 2017-05-31 | 刘吴阳 | A kind of feed addictive for calf indigestion |
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| CN101274081A (en) * | 2008-04-22 | 2008-10-01 | 梁进 | Paste for reinforcing spleen and promoting digestion |
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2013
- 2013-12-10 CN CN201310671669.9A patent/CN103800748A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101274081A (en) * | 2008-04-22 | 2008-10-01 | 梁进 | Paste for reinforcing spleen and promoting digestion |
Non-Patent Citations (3)
| Title |
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| 方雪: "苦杏仁能治哪些病", 《民族医药报》, 8 June 2007 (2007-06-08), pages 1 * |
| 杨凤琴: "川贝散治疗婴幼儿消化不良10例报告", 《黑龙江中医药》, no. 3, 31 December 1991 (1991-12-31), pages 38 * |
| 田连起等: "牵牛子（黑丑、白丑）生熟饮片的紫外谱线组法鉴别研究", 《中国民族民间医药》, no. 17, 31 December 2010 (2010-12-31), pages 23 - 24 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104273529A (en) * | 2014-09-26 | 2015-01-14 | 上海浦东高星生物技术研究所 | Dragon fruit tablets |
| CN104491592A (en) * | 2014-11-26 | 2015-04-08 | 山东永泰化工有限公司 | Health-care tea used for functional dyspepsia |
| CN105233095A (en) * | 2015-11-06 | 2016-01-13 | 李宏 | Formula and administration method of traditional Chinese medicine for treating stomach troubles |
| CN106138584A (en) * | 2016-07-21 | 2016-11-23 | 魏晓兵 | A kind of Chinese medicine of external application for curing stomachache |
| CN106720988A (en) * | 2016-11-30 | 2017-05-31 | 刘吴阳 | A kind of feed addictive for calf indigestion |
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Application publication date: 20140521 |