CN101279078A - Chinese medicinal composition for treating gastropathy and method of preparing the same - Google Patents
Chinese medicinal composition for treating gastropathy and method of preparing the same Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine combination for curing gastric diseases and a preparation method thereof, which solve the problem that the original traditional Chinese combinations for curing gastric diseases do not have prominent effects and have high recurrence rate. The medicine combination is prepared by corydalis tuber, Chinaberry fruit, turmeric root tuber, evodia rutaecarpa, coptis chinensis, villous amomum fruit, costus root, radix linderae, rhizoma cyperi, frankincense, myrrh and cuttlebone. The traditional Chinese medicine combination has the functions of soothing the liver and regulating vital energy, removing heat from the liver, promoting blood circulation to arrest pain, promoting wound healing and granulation, and can be used for curing gastric and duodenal ulcer, gastritis, stomachache, salivation and sour regurgitation, nausea, retching, epigastric distension and depression; besides, the traditional Chinese combination has special curative effects on gastric ulcer and duodenal ulcer and has inhibiting effect on helicobacter pylori.
Description
Technical field:
The invention belongs to the Chinese drug preparation technique field, be a kind of treatment gastric and duodenal ulcers, gastritis, stomachache, sialorrhea acid regurgitation, feel sick, gastropathy such as vomiting, upper abdomen feeling of distension and oppression, and helicobacter pylori had inhibiting Chinese medicine composition.
Background technology:
Gastric and duodenal ulcers is a kind of common frdquently encountered disease, and the patient is numerous, and therapeutic dose is big.In recent years,, adopt attack factor such as gastric acid inhibitory and pepsin and strengthen defense factor medicines such as blood flow, mucous secretion under the mucosa, become the main method of current treatment peptic ulcer along with the further investigation of peptic ulcer equilibrium theory utilization.Then owing to the progress of theory of infection, antimicrobial therapy also causes people's interest and attention, and various stomach medicines arise at the historic moment, and the medicine of many anti-alimentary tract ulcer occurs.Present these medicines, though obtain very big curative effect, but still have certain side effect and the high problem of relapse rate.In recent years the medicine that widely uses although obvious treatment, mitigation are arranged, certain side effect is arranged also, and relapse rate is higher, is difficult to radical cure.
Zuojin Wan so that Rhizoma Coptidis, Fructus Evodiae are formed has clearing away liver-fire, the function of stopping nausea and vomiting by lowering the adverse flow of QI; With Rhizoma Corydalis, the molecular Sichuan Chinaberry Powder of Fructus Toosendan, have soothing the liver expelling the heat-evil, the function of promoting the circulation of QI to relieve pain.But the function that the two does not possess the treatment gastric and duodenal ulcers does not separately possess the function for the treatment of other gastropathy yet.
Summary of the invention:
It is remarkable to the purpose of this invention is to provide various stomach effects such as a kind of treatment stomach and duodenal ulcer, and relapse rate is low, and helicobacter pylori is had inhibiting a kind of Chinese medicine composition for the treatment of gastropathy and preparation method thereof.
The present invention is achieved in that
A kind of Chinese medicine composition for the treatment of gastropathy is made by the crude drug of following portions by weight proportioning: Rhizoma Corydalis 10-60, Fructus Toosendan 8-30, Radix Curcumae 5-30, Fructus Evodiae 2-15, Rhizoma Coptidis 3-20, Fructus Amomi 5-20, Radix Aucklandiae (Radix Vladimiriae) 2-30, Radix Linderae 5-30, Rhizoma Cyperi 10-30, Olibanum 10-40, Myrrha 10-40, Endoconcha Sepiae 5-30.
A kind of Chinese medicine composition for the treatment of gastropathy is made by the crude drug of following portions by weight proportioning: Rhizoma Corydalis 40, Fructus Toosendan 20, Radix Curcumae 20, Fructus Evodiae 6, Rhizoma Coptidis 10, Fructus Amomi 15, Radix Aucklandiae (Radix Vladimiriae) 20, the Radix Linderae 12, Rhizoma Cyperi 15, Olibanum 24, Myrrha 24, Endoconcha Sepiae 20.
A kind of Chinese medicine composition for the treatment of gastropathy, preparation technology is: after Endoconcha Sepiae is pulverized into thin piece, be ground into fine powder with pulverizer, cross sieve six～No. eight, get the Endoconcha Sepiae powder, be used as medicine by recipe quantity; After Rhizoma Corydalis, Fructus Toosendan be ground into coarse powder, add 50%～98% (v/v) medicinal alcohol, heating and refluxing extraction 1～4 time, extraction time was followed successively by 100,60,40,20 minutes, merge extractive liquid,, decompress filter, filtrate becomes extractum in 40～80 ℃ of concentrating under reduced pressure, 30～60 ℃ of drying under reduced pressure become extract powder, and are standby; Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into middle powder earlier in the prescription ratio, mixing is crossed sieve three～No. five, after flooding 10～60 hours in right amount with 50%～98% (v/v) medicinal alcohol, the dress percolator carries out percolation with 50%～98% (v/v) medicinal alcohol, percolation speed is every 1000g medicated powder, per minute is collected 0.5～5ml, divides and collects percolate 1～4 time, and percolate is behind 40～80 ℃ of concentrating under reduced pressure, 30～60 ℃ of drying under reduced pressure become extract powder, and are standby; Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine are chopped into granule in the prescription ratio cross sieve one～No. three, add suitable quantity of water moistening after, place in the extractor, add the water of 6～20 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carried in about 2～15 hours to the greatest extent, tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby.With the said extracted thing, add the excipient mixing, granulate, through 50～80 ℃ of heat dryings.
A kind of Chinese medicine composition for the treatment of gastropathy, preparation technology is: after Endoconcha Sepiae is pulverized into thin piece, be ground into fine powder with pulverizer, cross sieve No. seven, get the Endoconcha Sepiae powder, be used as medicine by recipe quantity; After Rhizoma Corydalis, Fructus Toosendan be ground into coarse powder, add 70% (v/v) medicinal alcohol, heating and refluxing extraction 2 times, extraction time was followed successively by 60,40 minutes, merge extractive liquid,, decompress filter, filtrate becomes extractum in 50 ℃ of concentrating under reduced pressure, and 50 ℃ of drying under reduced pressure become extract powder, and are standby; Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into middle powder earlier in the prescription ratio, mixing is crossed sieve No. three, after flooding 48 hours in right amount with 85% (v/v) medicinal alcohol, the dress percolator carries out percolation with 85% (v/v) medicinal alcohol, percolation speed is every 1000g medicated powder, per minute is collected 1～3ml, divides and collects percolate 2 times, and percolate is behind 50 ℃ of concentrating under reduced pressure, 50 ℃ of drying under reduced pressure become extract powder, and are standby; Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine are chopped into granule in the prescription ratio cross sieve No. one, add suitable quantity of water moistening after, place in the extractor, add the water of 10 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carried in about 7～8 hours to the greatest extent, tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby; With the said extracted thing, add the excipient mixing, granulate, through 60 ℃ of heat dryings.
The dosage form of this Chinese medicine composition is a said dosage form on any pharmaceutics.
The dosage form of this Chinese medicine composition is granule, capsule or tablet.
The dosage form of this Chinese medicine composition is the stomach floating preparation.
The stomach floating preparation is intra-gastric floating tablet or gastric floating capsule or stomach floating particle or stomach Pellets Floating.
The present invention prescription is clinical experience side, and this root is seen pathogenic fire derived from stagnation of liver-QI according to primary disease is clinical more, the pathological characteristic of qi depression to blood stasis, with liver-smoothing, qi-regulating, liver heat removing purge heat, promoting blood circulation and stopping pain, expelling pus and promoting granulation be principle of treatment, draft in conjunction with its clinical experience.Prescription with Zuojin Wan (Rhizoma Coptidis, Fructus Evodiae) and Sichuan Chinaberry Powder (Rhizoma Corydalis, Fructus Toosendan) be basic framework add the flavor form.Zuojin Wan comes from " danxi's experiential therapy ", has clearing away liver-fire, the merit of stopping nausea and vomiting by lowering the adverse flow of QI; Sichuan Chinaberry Powder comes from " plain inquiring about disease machine gas should save one's life collection ", has soothing the liver expelling the heat-evil, the merit of promoting the circulation of QI to relieve pain; Help again with the Radix Curcumae circulation of qi promoting and stagnate, the heat of clearing heat in QI system branch and pain relieving; The Radix Aucklandiae, the Radix Linderae, Rhizoma Cyperi promoting the circulation of QI to relieve pain; The Fructus Amomi circulation of qi promoting is amusing, relieving pain by regulating middle-JIAO; Olibanum, Myrrha promoting blood circulation and stopping pain, detumescence and promoting granulation, kind controlling do not closed up after skin infection is burst for a long time; The Endoconcha Sepiae hemostasis with astringents is held back skin ulcer.All medicines share, and not only combine the Zuojin Wan clearing away liver-fire, and the effect of stopping nausea and vomiting by lowering the adverse flow of QI and Sichuan Chinaberry Powder are soothing the liver to expel the heat-evil, the effect of promoting the circulation of QI to relieve pain, and strengthened the merit of promoting the circulation of QI to relieve pain, and increased blood activating and promoting tissue regeneration at gastric and duodenal ulcers, astringent therapy is held back the effect of skin ulcer.Take a broad view of full side, adopt the length of many families, major-minor assistant makes, ties in, and prescription is rigorous, so the clinical application curative effect is quite outstanding.
Through clinical verification, be used for peptic ulcer [6 example]: clinical healing 3 examples (66%), 2 examples that take a turn for the better (33%), total effective rate 99%; Be used for gastritis [4 example]: clinical healing 1 example (25%), 2 examples that take a turn for the better (50%), total effective rate 75%; Be used for doing well,improving [10 example]: treatment back transference cure 7 examples (70%), 2 examples that take a turn for the better (20%), total effective rate 90%.It is very fast that the present invention improves symptom to gastropathy, more obvious with alleviating pain especially; Anastalsis is preferably arranged; Can promote ulcer healing.Do not see untoward reaction during the treatment.The present invention tests through in-vitro antibacterial, and helicobacter pylori is had inhibitory action; Through animal experiment, non-toxic reaction.
Effect and advantage that the present invention can reach are: specific treatment peptic ulcer, gastritis, stomachache, sialorrhea acid regurgitation, feel sick, gastropathy such as vomiting, upper abdomen feeling of distension and oppression, and helicobacter pylori had inhibiting Chinese medicine composition.Good analgesic effect of the present invention, ulcer healing are fast, are difficult for recurrence after the drug withdrawal, have no side effect, can the significant prolongation medicine at gastric transit time, improve the absorption of medicine, thereby improve bioavailability of medicament, medication is convenient.
Have excellent curative in order to ensure Chinese medicine composition of the present invention, carried out series of experimental research, specific as follows:
One, in-vitro antibacterial experiment:
Select " monkey mushroom bacterium ", " SANJIU WEITAI ", " Mistura Bismuthi Composta ", " Veytalo is peaceful ", " KUAIWEI PIAN ", " stomachache due to hyperactive liver-QI attacking the stomach sheet " six kinds to go on the market, determined curative effect, the high similar Chinese medicine in market share carries out external anti-helicobacter pylori experiment in contrast.
Result of the test explanation the present invention has definite helicobacter pylori inhibitory action.
Two, cure mainly relevant Pharmacodynamic test of active extract with function:
The present invention is clinical to be used to cure mainly gastric and duodenal ulcers, gastritis, stomachache, sialorrhea acid regurgitation, feel sick, vomiting, upper abdomen feeling of distension and oppression.The applicant has carried out anti-peptic ulcer, analgesia, antiphlogistic experimentation, to confirm main pharmacodynamics effect of the present invention, for its clinical research provides the drug effect foundation.
Result of the test shows:
(1) the present invention all can obviously reduce ulcer index due to the reserpine to big mice, and difference is extremely remarkable.None takes place gastric perforation in the administration group, and the model group punching rate reaches 4%.Ulcer inhibition rate has certain dose-effect relationship.
(2) the present invention treated acetic acid traumatic ulcer model 10 days to rat continuous irrigation stomach, and the ulcer area obviously dwindles than model group, and utmost point significant difference is arranged, and presents good dose-effect relationship, illustrated that this medicine has the effect of the ulcer healing of promotion.
(3) the present invention has definite protective effect to the gastric mucosa injury of alcohol-induced, presents good dose-effect relationship.
(4) the Dichlorodiphenyl Acetate liquid of the present invention mice pain of bringing out has the obvious suppression effect, and presents good dose-effect relationship, and the effect of inhibition of pain is strengthened along with the increase of dosage; Mice also there is obvious inhibitory action because of the pain that thermostimulation causes.
Can obviously suppress the secretion of rat gastric acid when (5) the present invention is heavy dose of, reduce the total acidity and the free acidity of gastric juice.Increase gastric secretion when low dose of.But total acidity gastric juice, free acidity and pepsin activity etc. there is not obviously influence.
(6) result in the test of mouse small intestine ahead running shows that the present invention does not have obvious effect to the mouse small intestine ahead running.
(7) the mice ear inflammation that causes of xylol of the present invention has the obvious anti-inflammatory and anti effect, and the concentration of its antiinflammatory action and this medicine that is coated with has a certain amount of effect relationship, increases the antiinflammatory action reinforcement with drug level.
(8) the mice ankle joint that brings out of PARA FORMALDEHYDE PRILLS(91,95) solution of the present invention is swollen an obvious anti-inflammatory and anti effect.
Show that by above animal test results the present invention has effects such as anti-gastric-ulcer, analgesia, antiinflammatory.
Three, animal acute toxicity test
By measuring the acute toxicity of the present invention, observe toxic reaction symptom and death condition, for clinical application safety dosage provides reference material to mice oral administration, mouse peritoneal injection, rat oral administration, rats by intraperitoneal injection.
This result of the test shows, at the Chinese medicine composition of treatment gastropathy for oral use, all is given to maximum volume regardless of rat, mice, and its reagent concentration also arrives maximum volume, and large and small Mus all occurs dead; This medicine of rats by intraperitoneal injection LD
50Greater than 6g/kg, mouse peritoneal is injected this medicine LD
50Greater than 15g/kg, large and small Mus does not all occur dead.
Four, long-term toxicity test for animals
Repeat continuously to give after the present invention heavy dose of and longer course of treatment to the issuable toxic reaction of rat by observing, the at first target organ of the signs of toxicity of Chu Xianing and the order of severity thereof, toxicity and recovery thereof and development, and the dosage of definite non-toxic reaction, for the clinical application safety evaluation provides reference.
The SD rat is gavaged the present invention every day respectively, 30,15, a 5g/day3 dosage, continuous 3 months, result of the test showed, and the low dose group animal goes out outside blood glucose value raises, and the equal Non Apparent Abnormality of every index changes.
Five, model case
The field, man, 40 years old, workman.Work unit: economize 23 companies that build.The patient is gastropathy for many years, obstinate.Be diagnosed as duodenal bulbar ulcer through barivm meal fluoroscopy (screem) in 1984.Take the present invention's treatment, day clothes three times, each 3 grams are obeyed 270 grams altogether.After January, carry out barivm meal fluoroscopy (screem) again, check result, ulcer recovery from illness.Appetite increases, and leanness disappears.Until in July, 1992, recurrence never.
Luo, man, 50 years old, peasant.District flame people from production team appeases the border area in the Yibin County.Having blood in stool appears in June, 1985, and it is more than to have a stomach-ache, and the health skeletonize has the rhythm and pace of moving things when having a stomach-ache, and is property on an empty stomach, and every day, food back pain slightly subtracted.Be diagnosed as the active stage gastric ulcer through barivm meal fluoroscopy (screem).Take the present invention's treatment, day clothes three times, each 3 grams, after the January of taking medicine, through the barivm meal fluoroscopy (screem) inspection, the gastropathy recovery from illness.The patient poisons because of once eating the fish of poisoning with poison by mistake after 3 years, comes to go to a doctor, and finds to have a stomach-ache, and again through barivm meal fluoroscopy (screem), turns out to be gastric ulcer recurrence, reuse the present invention treatment, and day clothes three times, each 3 grams are treated after one month transference cure.After change into and obey three every day, each 1-2 gram after taking medicine in two months, carries out barium meal examination, the gastropathy recovery from illness.To in July, 1992, do not see recurrence.
Lee, man, 34 years old, peasant, Yibin County Yulong village people.In July, 1985, the patient come to go to a doctor, the readme epigastrium pain of taking back, and whenever pain increases the weight of when hungry on an empty stomach, painful waking up in often sleeping night, and feel epigastrium center flatulence, and inappetence, diet reduces, the health leanness.Clinical examination is diagnosed as gastric ulcer.Through with the present invention's treatment, obey 9 grams day, after 20 days, the stomachache transference cure is not sent out so far.
Virgin certain, man, 31 years old, Yibin cadre of publicity department of county Party committee.Came to go to a doctor in 1987, readme barium meal examination is a gastric ulcer.The present invention treatment is taken in requirement, dosage day clothes 9 grams, the stomachache of clothes back alleviates, through continuing treatment January, patient's disappearance of having a stomachache is not sent out so far.
Permitted certain, woman, 40 years old, big people from Anxiang of Zigong City.The patient has a stomach-ache the several years, and treatment is recovery from illness not, comes to go to a doctor in 84 years.Use barivm meal fluoroscopy (screem), be diagnosed as gastric ulcer.The bimester treating with the present invention, barivm meal fluoroscopy (screem), gastric ulcer recovery from illness, recurrence never so far.
Military certain, man, 40 years old, workman.Yibin County Chinese crude drug retail sales work.Went to a doctor before nineteen eighty-two, the time health become thin, diet goes down, and often feels epigastrium dull pain, attaches most importance to during especially with hunger.Through barivm meal fluoroscopy (screem) is duodenal bulbar ulcer.Through taking the present invention, restrain every days 9, and sx after 10 days is clearly better.Medicining mode: every day three times, each three grams, the morning 9～10 o'clock at 4 o'clock in afternoon, service once before sleeping evening.Take medicine after January, the gastropathy recovery from illness was not recurred so far.
Poplar, man, 50 years old, the work of Yibin County capital construction commission.Came to go to a doctor in 1987, and showed the barivm meal fluoroscopy (screem) result and be duodenal bulbar ulcer.Take the present invention, day clothes 9 grams, after 20 days, the readme stomachache disappears, and does not recur so far.
Separate certain, the woman, 38 years old, the district grade teacher appeased the border area in the Yibin County.In December, 1988 comes to go to a doctor, and stomachache is often felt in readme, takes medicine for many years, does not take effect yet.Through clinical diagnosis is gastric ulcer.Take the present invention's treatment, day clothes 9 grams, after taking medicine 25, patient's transference cure did not recur so far.
Cao, man, 39 years old, Yibin City Jin Ping township peasant.Examine in February, 1992, and the readme belch emits acid, and epigastrium hits exactly the dull pain that takes over.Be diagnosed as duodenal bulbar ulcer through gastroscopy, and superficial gastritis is arranged.Through clothes the present invention, pain subtracts greatly after a few days, and symptom is clearly better.9 grams of taking medicine every day, stomachache in 15 days disappears, and diet increases.Readme gastropathy is fully recovered, so far not recurrence.
Poplar, man, 63 years old, the county annals office work of the Yibin County People's Government.The stomachache several years, gastroscopy in 1974 is a pylorus edema and with chronic superficial gastritis, through treatment for many years, fail to cure, took medicine 20 through taking the former side's powder treatment of the present invention in 1986, totally 9 restrain once a day, sb.'s illness took a favorable turn, after January, took medicine 20 approximately again, dosage such as preceding, the gastropathy recovery from illness, the health rejuvenation is not sent out so far.
Liu, woman, 26 years old, Yibin County Bai Xi people from town.In March, 1992, patient's clinical diagnosis is an acute gastroenteritis, takes the present invention, and day clothes 9 grams were treated 20 days.Patient's readme stomachache recovery from illness was not recurred.
Grandson, woman, 60 years old.The Yibin County government work, retirement, pain below the right hypochondrium, gastral cavilty portion, abdominal part distending pain, belch giddy, constipation.Take the former side's decoction of the present invention Second Mate, took in three days, clinical condition of illness disappears at once.
Zeng, man, 25 years old, Yibin County hospital work.In April, 1992, stomachache comes to go to a doctor, clothes the present invention, and two days later, stomachache promptly ends.
Thank certain, the woman 6 years old, lives the Yibin County oil extraction plant.Anorexia, cough, white and slippery fur is greasy.The former side's decoction of clothes the present invention Second Mate is almost recovered.
Liu, woman, 60 years old, the retired cadre of Yibin County county trade union.The patient examines in March, 1992.Condition of illness: anorexia, appetite reduces, and is weak, abdominal distention.Clinical diagnosis is a gastritis.Through the former side's decoction of clothes the present invention, cure.
Liu, woman, 25 years old, the cadre of Yibin County hydroelectric board.Symptom during prescription on individual diagnosis: gastric abscess, diet minimizing, abdominal distention, with red tongue, oral ulcer.Through taking we, potion promptly turns for the better by and large.
Appoint certain, man, 40 years old, the two River Reservoir managers in Yibin County.Often stomachache comes to go to a doctor, and the former side's powder of clothes the present invention is through taking medicine a week sick recovery from illness.
Huang, the man, 26 years old, class's work was driven at driver training center, Yibin City residential district.Before the prescription on individual diagnosis, abdominal distention, diarrhoea, giddy, diet reduce.Through with the former side's decoction treatment of the present invention, take medicine a week, recover.
Hu, woman, 66 years old, Bai Xi town, household Yibin County Yang Jiacijie.Patient's gastral cavilty, two side of body distending pain, belch.Through the former side's decoction of clothes the present invention Second Mate, recover.
Cao, the woman 43 years old, lives railway station, Bai Xi town, Yibin County.Patient's readme: abdominal part gastral cavilty place distending pain.Clinical diagnosis is a chronic gastritis, through promptly healing with the former side's decoction treatment of the present invention.
The Wang, woman, 38 years old, Yibin County Bai Xi people from town.During prescription on individual diagnosis, the gastral cavilty dull pain of taking back is diagnosed as chronic gastritis.Treat recovery from illness with the present invention.
The specific embodiment:
The invention will be further described with embodiment below:
Embodiment 1:
Composition of raw materials: Rhizoma Corydalis 40 gram Fructus Toosendans 20 grams
Radix Curcumae 20 gram Fructus Evodiaes 6 grams
Rhizoma Coptidis 10 gram Fructus Amomis 15 grams
The Radix Aucklandiae (Radix Vladimiriae) 20 gram Radixs Linderae 12 grams
Rhizoma Cyperi 15 gram Olibanums 24 grams
Myrrha 24 gram Endoconcha Sepiaes 20 grams
Preparation method:
(1) Endoconcha Sepiae is pulverized into thin piece after, be ground into fine powder with pulverizer, cross sieve for No. seven the Endoconcha Sepiae powder, be used as medicine by recipe quantity;
(2) Rhizoma Corydalis, Fructus Toosendan are ground into coarse powder after, add 70% (v/v) medicinal alcohol, heating and refluxing extraction 2 times (extraction time was followed successively by 60,40 minutes), merge extractive liquid,, decompress filter, filtrate becomes extractum in 50 ℃ of concentrating under reduced pressure, and drying under reduced pressure becomes extract powder (50 ℃ of temperature), the content of its tetrahydropalmatine is 0.6%, and is standby;
(3) Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into middle powder earlier in the prescription ratio, mixing is crossed sieve No. three, after flooding 48 hours in right amount with 85% (v/v) medicinal alcohol, the dress percolator, carry out percolation with 85% (v/v) medicinal alcohol, percolation speed is every 1000g medicated powder, per minute is collected 1～3ml, divide and collect percolate 2 times, percolate is behind 50 ℃ of concentrating under reduced pressure, 50 ℃ of drying under reduced pressure become extract powder, and the total content that the content that contains berberine is 15.6%, contain rutaecarpin and rutaecarpine is 0.38%, and is standby;
(4) Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine are chopped into granule in the prescription ratio and cross sieve No. one, add suitable quantity of water moistening after, place in the extractor, add the water of 10 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carried in about 7～8 hours to the greatest extent, tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby;
(5) with the said extracted thing, add dextrin or starch mixing, granulate, through 60 ℃ of heat dryings, make the granule that per 10 gram granules contain crude drug 3.75 grams.
Embodiment 2:
Composition of raw materials: Rhizoma Corydalis 60 gram Fructus Toosendans 8 grams
Radix Curcumae 30 gram Fructus Evodiaes 15 grams
Rhizoma Coptidis 6 gram Fructus Amomis 20 grams
The Radix Aucklandiae (Radix Vladimiriae) 6 gram Radixs Linderae 30 grams
Rhizoma Cyperi 20 gram Olibanums 10 grams
Myrrha 40 gram Endoconcha Sepiaes 22 grams
Preparation method:
(1) Endoconcha Sepiae is pulverized into thin piece after, be ground into fine powder with pulverizer, cross sieve for No. six the Endoconcha Sepiae powder, be used as medicine by recipe quantity;
(2) Rhizoma Corydalis, Fructus Toosendan are ground into coarse powder after, add 98% (v/v) medicinal alcohol, heating and refluxing extraction 2 times (extraction time was followed successively by 60,40 minutes), merge extractive liquid,, decompress filter, filtrate becomes extractum in 80 ℃ of concentrating under reduced pressure, and drying under reduced pressure becomes extract powder (60 ℃ of temperature), the content of its tetrahydropalmatine is 0.4%, and is standby;
(3) Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into middle powder earlier in the prescription ratio, mixing is crossed sieve No. five, flood 20 hours in right amount with 75% (v/v) medicinal alcohol after, adorn percolator, carry out percolation with 75% (v/v) medicinal alcohol.Percolation speed is every 1000g medicated powder, and per minute is collected 3ml.Divide and collect percolate 3 times.Percolate is behind 80 ℃ of concentrating under reduced pressure, and drying under reduced pressure becomes extract powder (30 ℃ of temperature), and the total content that the content that contains berberine is 5.2%, contain rutaecarpin and rutaecarpine is 0.16%, and is standby;
(4) Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine (in the prescription ratio) are chopped into granule and cross sieve No. three, add suitable quantity of water moistening after, place in the extractor, add the water of 6 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carry most oil (about 7 hours), tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby;
(5) with the said extracted thing, add lactose, dextrin, pregelatinized Starch or microcrystalline Cellulose mixing, granulate, through 50 ℃ of heat dryings, make the tablet that per 10 gram granules contain crude drug 3.75 grams.
Embodiment 3:
Composition of raw materials: Rhizoma Corydalis 10 gram Fructus Toosendans 10 grams
Radix Curcumae 5 gram Fructus Evodiaes 2 grams
Rhizoma Coptidis 20 gram Fructus Amomis 10 grams
The Radix Aucklandiae (Radix Vladimiriae) 5 gram Radixs Linderae 25 grams
Rhizoma Cyperi 10 gram Olibanums 40 grams
Myrrha 10 gram Endoconcha Sepiaes 5 grams
Preparation method:
(1) Endoconcha Sepiae is pulverized into thin piece after, be ground into fine powder with pulverizer, cross sieve for No. seven the Endoconcha Sepiae powder, be used as medicine by recipe quantity;
(2) Rhizoma Corydalis, Fructus Toosendan are ground into coarse powder after, add 85% (v/v) medicinal alcohol, heating and refluxing extraction 4 times (extraction time was followed successively by 100,60,40,20 minutes), merge extractive liquid,, decompress filter, filtrate becomes extractum in concentrating under reduced pressure below 40 ℃, and drying under reduced pressure becomes extract powder (50 ℃ of temperature), the content of its tetrahydropalmatine is 0.5%, and is standby;
(3) Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into earlier in the prescription ratio in the powder mixing cross sieve No. seven, flood 30 hours in right amount with 50% (v/v) medicinal alcohol after, adorn percolator, carry out percolation with 50% (v/v) medicinal alcohol.Percolation speed is every 1000g medicated powder, and per minute is collected 0.5ml.Divide and collect percolate 4 times.Percolate is behind concentrating under reduced pressure below 70 ℃, and drying under reduced pressure becomes extract powder (60 ℃ of temperature), and wherein, the content that Rhizoma Coptidis contains berberine is 7.4%, the total content of Fructus Evodiae and rutaecarpine is 0.28%, and is standby;
(4) Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine (in the prescription ratio) are chopped into granule and cross sieve No. two, add suitable quantity of water moistening after, place in the extractor, add the water of 8 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carry most oil (about 8 hours), tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby;
(5) with the said extracted thing, add dextrin or starch mixing, granulate, through 80 ℃ of heat dryings, make the granule that per 10 gram granules contain crude drug 3.75 grams.
Embodiment 4:
Composition of raw materials: Rhizoma Corydalis 50 gram Fructus Toosendans 30 grams
Radix Curcumae 5 gram Fructus Evodiaes 15 grams
Rhizoma Coptidis 3 gram Fructus Amomis 30 grams
The Radix Aucklandiae (Radix Vladimiriae) 2 gram Radixs Linderae 5 grams
Rhizoma Cyperi 30 gram Olibanums 20 grams
Myrrha 20 gram Endoconcha Sepiaes 30 grams
Preparation method:
(1) Endoconcha Sepiae is pulverized into thin piece after, be ground into fine powder with pulverizer, cross sieve for No. seven the Endoconcha Sepiae powder, be used as medicine by recipe quantity;
(2) Rhizoma Corydalis, Fructus Toosendan are ground into coarse powder after, add 50% (v/v) medicinal alcohol, heating and refluxing extraction 3 times (extraction time was followed successively by 60,40,20 minutes), merge extractive liquid,, decompress filter, filtrate becomes extractum in concentrating under reduced pressure below 60 ℃, and drying under reduced pressure becomes extract powder (30 ℃ of temperature), the content of its tetrahydropalmatine is 0.4%, and is standby;
(3) Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into earlier in the prescription ratio in the powder mixing cross sieve No. four, flood 60 hours in right amount with 98% (v/v) medicinal alcohol after, adorn percolator, carry out percolation with 98% (v/v) medicinal alcohol.Percolation speed is every 1000g medicated powder, and per minute is collected 5ml.Divide and collect percolate 2 times.Percolate is behind 70 ℃ of concentrating under reduced pressure, and drying under reduced pressure becomes extract powder (50 ℃ of temperature), and wherein, the content that Rhizoma Coptidis contains berberine is 8.5%, the total content of Fructus Evodiae and rutaecarpine is 0.32%, and is standby;
(4) Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine (in the prescription ratio) are chopped into granule and cross sieve No. one, add suitable quantity of water moistening after, place in the extractor, add the water of 20 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carry most oil (about 15 hours), tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby;
(5) with the said extracted thing, add mannitol, dextrin, starch or lactose mixing, to granulate, 60 ℃ of heat dryings are made the content that per 10 gram granules contain crude drug 3.75 grams, insert capsule promptly.
Embodiment 5
Composition of raw materials: Rhizoma Corydalis 20 gram Fructus Toosendans 20 grams
Radix Curcumae 15 gram Fructus Evodiaes 12 grams
Rhizoma Coptidis 10 gram Fructus Amomis 5 grams
The Radix Aucklandiae (Radix Vladimiriae) 30 gram Radixs Linderae 5 grams
Rhizoma Cyperi 15 gram Olibanums 30 grams
Myrrha 30 gram Endoconcha Sepiaes 30 grams
Preparation method:
(1) Endoconcha Sepiae is pulverized into thin piece after, be ground into fine powder with pulverizer, cross sieve No. six, the Endoconcha Sepiae powder, be used as medicine by recipe quantity;
(2) Rhizoma Corydalis, Fructus Toosendan are ground into coarse powder after, add 90% (v/v) medicinal alcohol, heating and refluxing extraction 1 time (extraction time was followed successively by 100 minutes), merge extractive liquid,, decompress filter, filtrate becomes extractum in concentrating under reduced pressure below 40 ℃, and drying under reduced pressure becomes extract powder (40 ℃ of temperature), the content of its tetrahydropalmatine is 0.2%, and is standby;
(3) Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into earlier in the prescription ratio in the powder mixing cross sieve No. three, flood 10 hours in right amount with 50% (v/v) medicinal alcohol after, adorn percolator, carry out percolation with 50% (v/v) medicinal alcohol.Percolation speed is every 1000g medicated powder, and per minute is collected 2ml.Divide and collect percolate 3 times.Percolate is behind 40 ℃ of concentrating under reduced pressure, and drying under reduced pressure becomes extract powder (50 ℃ of temperature), and wherein, the content that Rhizoma Coptidis contains berberine is 6.9%, the total content of Fructus Evodiae and rutaecarpine is 0.15%, and is standby;
(4) Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine (in the prescription ratio) are chopped into granule and cross sieve No. two, add suitable quantity of water moistening after, place in the extractor, add the water of 15 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carry most oil (about 12 hours), tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby;
(5) with the said extracted thing, add dextrin or starch mixing, to granulate, 70 ℃ of heat dryings are made the granule that per 10 gram granules contain crude drug 3.75 grams.
Embodiment 6
Composition of raw materials: Rhizoma Corydalis 40 gram Fructus Toosendans 20 grams
Radix Curcumae 10 gram Fructus Evodiaes 15 grams
Rhizoma Coptidis 15 gram Fructus Amomis 18 grams
The Radix Aucklandiae (Radix Vladimiriae) 20 gram Radixs Linderae 20 grams
Rhizoma Cyperi 20 gram Olibanums 25 grams
Myrrha 25 gram Endoconcha Sepiaes 25 grams
Preparation method:
(1) Endoconcha Sepiae is pulverized into thin piece after, be ground into fine powder with pulverizer, cross sieve for No. eight the Endoconcha Sepiae powder, be used as medicine by recipe quantity;
(2) Rhizoma Corydalis, Fructus Toosendan are ground into coarse powder after, add 65% (v/v) medicinal alcohol, heating and refluxing extraction 3 times (extraction time was followed successively by 100,60,40 minutes), merge extractive liquid,, decompress filter, filtrate becomes extractum in concentrating under reduced pressure below 70 ℃, and drying under reduced pressure becomes extract powder (50 ℃ of temperature), the content of its tetrahydropalmatine is 0.5%, and is standby;
(3) Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into earlier in the prescription ratio in the powder mixing cross sieve No. three, flood 48 hours in right amount with 60% (v/v) medicinal alcohol after, adorn percolator, carry out percolation with 60% (v/v) medicinal alcohol.Percolation speed is every 1000g medicated powder, and per minute is collected 1ml, divides and collects percolate 1 time.Percolate is behind 70 ℃ of concentrating under reduced pressure, and drying under reduced pressure becomes extract powder (50 ℃ of temperature), and wherein, the content that Rhizoma Coptidis contains berberine is 10.7%, the total content of Fructus Evodiae and rutaecarpine is 0.31%, and is standby;
(4) Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine (in the prescription ratio) are chopped into granule and cross sieve No. two, add suitable quantity of water moistening after, place in the extractor, add the water of 12 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carry most oil (about 2 hours), tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby;
(5) with the said extracted thing, add lactose, dextrin, pregelatinized Starch, microcrystalline Cellulose, hydroxypropyl emthylcellulose, chitin or carbomer mixing, granulate, 80 ℃ of heat dryings, tabletting is made the intra-gastric floating tablet agent that per 10 gram granules contain crude drug 3.75 grams.
Claims (8)
1, a kind of Chinese medicine composition for the treatment of gastropathy is characterized in that being made by the crude drug of following portions by weight proportioning: Rhizoma Corydalis 10-60, Fructus Toosendan 8-30, Radix Curcumae 5-30, Fructus Evodiae 2-15, Rhizoma Coptidis 3-20, Fructus Amomi 5-20, Radix Aucklandiae (Radix Vladimiriae) 2-30, Radix Linderae 5-30, Rhizoma Cyperi 10-30, Olibanum 10-40, Myrrha 10-40, Endoconcha Sepiae 5-30.
2, a kind of Chinese medicine composition for the treatment of gastropathy according to claim 1 is characterized in that being made by the crude drug of following portions by weight proportioning: Rhizoma Corydalis 40, Fructus Toosendan 20, Radix Curcumae 20, Fructus Evodiae 6, Rhizoma Coptidis 10, Fructus Amomi 15, Radix Aucklandiae (Radix Vladimiriae) 20, the Radix Linderae 12, Rhizoma Cyperi 15, Olibanum 24, Myrrha 24, Endoconcha Sepiae 20.
3, the method for the Chinese medicine composition of preparation treatment gastropathy as claimed in claim 1 is characterized in that preparation method is: after Endoconcha Sepiae is pulverized into thin piece, be ground into fine powder with pulverizer, cross sieve six～No. eight, get the Endoconcha Sepiae powder, be used as medicine by recipe quantity; After Rhizoma Corydalis, Fructus Toosendan be ground into coarse powder, add 50%～98% (v/v) medicinal alcohol, heating and refluxing extraction 1～4 time, extraction time was followed successively by 100,60,40,20 minutes, merge extractive liquid,, decompress filter, filtrate becomes extractum in 40～80 ℃ of concentrating under reduced pressure, 30～60 ℃ of drying under reduced pressure become extract powder, and are standby; Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into middle powder earlier in the prescription ratio, mixing is crossed sieve three～No. five, after flooding 10～60 hours in right amount with 50%～98% (v/v) medicinal alcohol, the dress percolator carries out percolation with 50%～98% (v/v) medicinal alcohol, percolation speed is every 1000g medicated powder, per minute is collected 0.5～5ml, divides and collects percolate 1～4 time, and percolate is behind 40～80 ℃ of concentrating under reduced pressure, 30～60 ℃ of drying under reduced pressure become extract powder, and are standby; Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine are chopped into granule in the prescription ratio cross sieve one～No. three, add suitable quantity of water moistening after, place in the extractor, add the water of 6～20 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carried in about 2～15 hours to the greatest extent, tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby.With the said extracted thing, add the excipient mixing, granulate, through 50～80 ℃ of heat dryings.
4, the method for the Chinese medicine composition of preparation treatment gastropathy as claimed in claim 1 is characterized in that preparation method is: after Endoconcha Sepiae is pulverized into thin piece, be ground into fine powder with pulverizer, cross sieve No. seven, get the Endoconcha Sepiae powder, be used as medicine by recipe quantity; After Rhizoma Corydalis, Fructus Toosendan be ground into coarse powder, add 70% (v/v) medicinal alcohol, heating and refluxing extraction 2 times, extraction time was followed successively by 60,40 minutes, merge extractive liquid,, decompress filter, filtrate becomes extractum in 50 ℃ of concentrating under reduced pressure, and 50 ℃ of drying under reduced pressure become extract powder, and are standby; Fructus Evodiae, Rhizoma Coptidis, the Radix Linderae three flavor medicines are ground into middle powder earlier in the prescription ratio, mixing is crossed sieve No. three, after flooding 48 hours in right amount with 85% (v/v) medicinal alcohol, the dress percolator carries out percolation with 85% (v/v) medicinal alcohol, percolation speed is every 1000g medicated powder, per minute is collected 1～3ml, divides and collects percolate 2 times, and percolate is behind 50 ℃ of concentrating under reduced pressure, 50 ℃ of drying under reduced pressure become extract powder, and are standby; Radix Curcumae, Fructus Amomi, Rhizoma Cyperi, the Radix Aucklandiae, Olibanum, Myrrha Six-element medicine are chopped into granule in the prescription ratio cross sieve No. one, add suitable quantity of water moistening after, place in the extractor, add the water of 10 times of amounts, use the steam heating distillation extraction, volatile oil companion steam distillates in the lump, and after condenser condenses, volatile oil is then separated out in the receptor upper strata, carried in about 7～8 hours to the greatest extent, tell the transparent oil reservoir in upper strata, and the volatile oil that obtains with this extraction of beta-cyclodextrin inclusion compound, standby; With the said extracted thing, add the excipient mixing, granulate, through 60 ℃ of heat dryings.
5, a kind of Chinese medicine composition for the treatment of gastropathy according to claim 1, the dosage form that it is characterized in that this Chinese medicine composition is a said dosage form on any pharmaceutics.
6, a kind of Chinese medicine composition for the treatment of gastropathy according to claim 1, the dosage form that it is characterized in that this Chinese medicine composition is granule, capsule or tablet.
7, a kind of Chinese medicine composition for the treatment of gastropathy according to claim 1, the dosage form that it is characterized in that this Chinese medicine composition is the stomach floating preparation.
8, a kind of Chinese medicine composition for the treatment of gastropathy according to claim 7 is characterized in that the stomach floating preparation is intra-gastric floating tablet or gastric floating capsule or stomach floating particle or stomach Pellets Floating.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102151304A (en) * | 2011-01-25 | 2011-08-17 | 四川省中医药科学院 | Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof |
| CN102188663A (en) * | 2010-03-09 | 2011-09-21 | 吴振中 | Chinese medicine for treating chronic atrophic gastritis |
| CN102895381A (en) * | 2012-11-13 | 2013-01-30 | 李新欣 | Traditional Chinese medicine for treating bile reflux gastritis |
| CN103040876A (en) * | 2012-12-17 | 2013-04-17 | 浙江佐力药业股份有限公司 | Preparation method for composition of solid traditional Chinese medicine particles |
| CN104189425A (en) * | 2014-08-15 | 2014-12-10 | 刘振声 | Traditional Chinese medicine preparation for treating gastropathy |
| CN104399011A (en) * | 2014-12-16 | 2015-03-11 | 孔馨苑 | Traditional Chinese medicine combination for treating esophageal cancer pain and preparation method thereof |
| CN105168794A (en) * | 2015-11-03 | 2015-12-23 | 李金友 | Pharmaceutical composition and preparation method, preparations and application thereof |
| CN105497361A (en) * | 2015-12-21 | 2016-04-20 | 荥阳市藤本保健品有限公司 | Inflammation-diminishing, pain-relieving and depression-dispersing decoction |
| CN105833165A (en) * | 2016-06-03 | 2016-08-10 | 吕灿利 | Traditional Chinese medicine composition for treating gastric disease |
| CN108310296A (en) * | 2018-04-23 | 2018-07-24 | 党东 | A kind of Solid oral pharmaceutical for treating stomach trouble |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188663A (en) * | 2010-03-09 | 2011-09-21 | 吴振中 | Chinese medicine for treating chronic atrophic gastritis |
| CN102188663B (en) * | 2010-03-09 | 2012-06-27 | 吴振中 | Chinese medicine for treating chronic atrophic gastritis |
| CN102151304B (en) * | 2011-01-25 | 2012-08-22 | 四川省中医药科学院 | Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof |
| CN102151304A (en) * | 2011-01-25 | 2011-08-17 | 四川省中医药科学院 | Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof |
| CN102895381A (en) * | 2012-11-13 | 2013-01-30 | 李新欣 | Traditional Chinese medicine for treating bile reflux gastritis |
| CN103040876B (en) * | 2012-12-17 | 2015-03-25 | 浙江佐力药业股份有限公司 | Preparation method for composition of solid traditional Chinese medicine particles |
| CN103040876A (en) * | 2012-12-17 | 2013-04-17 | 浙江佐力药业股份有限公司 | Preparation method for composition of solid traditional Chinese medicine particles |
| CN104189425A (en) * | 2014-08-15 | 2014-12-10 | 刘振声 | Traditional Chinese medicine preparation for treating gastropathy |
| CN104399011A (en) * | 2014-12-16 | 2015-03-11 | 孔馨苑 | Traditional Chinese medicine combination for treating esophageal cancer pain and preparation method thereof |
| CN105168794A (en) * | 2015-11-03 | 2015-12-23 | 李金友 | Pharmaceutical composition and preparation method, preparations and application thereof |
| CN105497361A (en) * | 2015-12-21 | 2016-04-20 | 荥阳市藤本保健品有限公司 | Inflammation-diminishing, pain-relieving and depression-dispersing decoction |
| CN105833165A (en) * | 2016-06-03 | 2016-08-10 | 吕灿利 | Traditional Chinese medicine composition for treating gastric disease |
| CN108310296A (en) * | 2018-04-23 | 2018-07-24 | 党东 | A kind of Solid oral pharmaceutical for treating stomach trouble |
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