CN105056196A - Medicine composition for treating peptic ulcer and preparing method thereof - Google Patents

Abstract

The invention relates to a medicine composition for treating the peptic ulcer and a preparing method thereof. The medicine composition has the advantages of being high in curative rate and effective rate, free of toxic and side effects, short in treatment cycle and free of relapsing. The medicine composition comprises, by weight, 10 g to 20 g of red ginseng, 10 g to 20 g of rheum officinale, 10 g to 20 g of fresh ginger, 30 g to 60 g of radix gentianae, 30 g to 60 g of liquorice, 30 g to 60 g of rhizoma cyperi, 5 g to 10 g of bighead atractylodes rhizomes and 5 g to 10 g of betel nuts. According to the medicine composition and the preparing method, the medicinal components are scientifically and reasonably mixed according to the pathogenesis, mutually supported and mutually matched, the side effects on the body are reduced while the medicine curative effect is achieved, and the effects of effective medicine ingredients are sufficiently achieved while invalid impurities are removed.

Description

A kind of pharmaceutical composition for the treatment of peptic ulcer and preparation method thereof

Technical field

The present invention relates to field of medicaments, particularly a kind of pharmaceutical composition for the treatment of peptic ulcer and preparation method thereof.

Background technology

Peptic ulcer mainly refers to betide the duodenal chronic ulcer of harmonization of the stomach, is a frequently-occurring disease, commonly encountered diseases.Ulcer be formed with various factors, wherein the Digestion of acidic gastric juice to mucosa is the Fundamentals of ulcer, hence obtains one's name.Any position of acidic gastric juice contact, as distal esophagus, the postoperative anastomotic stoma of gastrointestinal anastomosis, jejunum and the Meckel diverticulum with Ectopic Gastric Mucosa, most ulcer betides duodenum stomach function regulating, therefore also known as taste-blindness rate.

Experiment and clinic presentations research in recent years shows, it is the key link causing peptic ulcer that gastroxia, helicobacter pylori infections and the protective effects on gastric mucosa such as to weaken at the factor.Gastric emptying and bile reflux, the effect of gastrointestinal peptide, inherited genetic factors, medicine factor, environmental factors and Nervous and Mental Factors etc., all relevant with the generation of peptic ulcer.

Outside other symptom primary disease a good appetite suddenly appearing in a serious disease Upper abdominal paines, salivation still can be had to increase, heartburn, regurgitation, acid eructation, belch, other gastrointestinal symptoms such as Nausea and vomiting.The many maintenances of appetite are normal, but occasionally can fear food because eating rear panic attacks, so that lose weight.General Symptoms can have the neurosal performances such as insomnia, or has the unbalanced symptom of the autonomic nervous system such as moderate pulse, hyperhidrosis.

Sign ulcer stage of attack, middle epigastrium can have local tenderness, and degree does not weigh, and its tenderness position is many to conform to substantially with the position of ulcer.

Under the promotion of the factors such as living standard raising, rhythm of life quickening, city crowd's digestive system disease takes place frequently.According to data, the total prevalence rate of gastrointestinal disease is up to more than 50%, and wherein Peptic Ulcers accounts for more than 10% again.As everyone knows, peptic ulcer is one of more obstinate disease, and relapse rate is very high, and year, relapse rate was up to more than 70%, visible treatment thorny.From medical market, gastrointestinal drug constantly " weeding out the old and bring forth the new " and market phenomenon prosperous without obstacle all the time, can see two main trend: one is that Peptic Ulcers patient constantly increases; Two is that research and development stomach medicine has a extensive future, and therefore develops the above-mentioned disease of a kind of effective treatment and puts into medicine and have very big realistic meaning for the healthy cause of the mankind.

Summary of the invention

In order to overcome above-mentioned defect, the invention provides a kind of pharmaceutical composition for the treatment of peptic ulcer and preparation method thereof, there is cure rate and effective percentage high, have no side effect, treatment cycle is short, without recurrence effect.

The pharmaceutical composition that the present invention treats peptic ulcer is made up of the crude drug of following weighing scale: Radix Ginseng Rubra 10 ~ 20g, Radix Et Rhizoma Rhei 10 ~ 20g, Rhizoma Zingiberis Recens 10 ~ 20g, Radix Gentianae 30 ~ 60g, Radix Glycyrrhizae 30 ~ 60g, Rhizoma Cyperi 30 ~ 60g, the Rhizoma Atractylodis Macrocephalae 5 ~ 10g and Semen Arecae 5 ~ 10g;

Its preparation method is:

(1) first Radix Ginseng Rubra water shower is cleaned, to put in baking oven 75-85 DEG C and dry, pulverize, cross 100 mesh sieves, obtain Radix Ginseng Rubra fine powder;

(2) by Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Radix Gentianae, Radix Glycyrrhizae, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Semen Arecae totally seven taste crude drug decoct with water twice, first time adds the water of seven taste crude drug weight 9-11 times amount, extracts 1.5-2.5 hour; Filter, medicinal residues add the water of seven taste crude drug weight 7-9 times amount again, extract 1-1.5 hour, filter, merge twice filtrate; Be evaporated to the thick paste that 80 DEG C ~ 90 DEG C are surveyed relative density 1.35 ~ 1.40;

(3) in thick paste, add Radix Ginseng Rubra fine powder and starch 200g-400g granulates, the granule made is put in ebullated dryer, under 60 ~ 80 DEG C of conditions, is dried to dry granule; Described starch is any one in the starch such as sweet potato starch, potato starch, corn starch.

(4) add the magnesium stearate of dry particle weight 1%, mixing, tabletting, to obtain final product.

The present invention is directed to the cause of disease, scientific and reasonable allotment drug component, mutually supports to each other, cooperatively interacts, and while playing curative effect of medication, reduces the side effect to health, while eliminating invalid impurity, has given full play to the effect of effective ingredient.

Specific embodiments

Below in conjunction with example, the specific embodiment of the present invention is described in further details.

Embodiment 1

The present invention treats the pharmaceutical composition of peptic ulcer by weighing scale: Radix Ginseng Rubra 10g, Radix Et Rhizoma Rhei 10g, Rhizoma Zingiberis Recens 10g, Radix Gentianae 30g, Radix Glycyrrhizae 30g, Rhizoma Cyperi 30g, Rhizoma Atractylodis Macrocephalae 5g and Semen Arecae 5g make as material medicine, and its preparation method is:

Its preparation method is:

(1) first Radix Ginseng Rubra water shower is cleaned, to put in baking oven 75 DEG C and dry, pulverize, cross 100 mesh sieves, obtain Radix Ginseng Rubra fine powder;

(2) by Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Radix Gentianae, Radix Glycyrrhizae, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Semen Arecae totally seven taste crude drug decoct with water twice, first time adds the water of seven taste crude drug weight 9 times amount, extracts 1.5 hours; Filter, medicinal residues add the water of seven taste crude drug weight 7 times amount again, extract 1 hour, filter, merge twice filtrate; Be evaporated to the thick paste that 80 DEG C are surveyed relative density 1.40;

(3) in thick paste, add Radix Ginseng Rubra fine powder and starch 200g, granulate, the granule made is put in ebullated dryer, under 60 DEG C of conditions, is dried to dry granule;

(4) add the magnesium stearate of dry particle weight 1%, mixing, tabletting, to obtain final product.

Embodiment 2

The present invention treats the pharmaceutical composition of peptic ulcer by weighing scale: Radix Ginseng Rubra 15g, Radix Et Rhizoma Rhei 15g, Rhizoma Zingiberis Recens 15g, Radix Gentianae 45g, Radix Glycyrrhizae 45g, Rhizoma Cyperi 45g, Rhizoma Atractylodis Macrocephalae 7.5g and Semen Arecae 7.5g make as material medicine, and its preparation method is:

(1) first Radix Ginseng Rubra water shower is cleaned, to put in baking oven 80 DEG C and dry, pulverize, cross 100 mesh sieves, obtain Radix Ginseng Rubra fine powder;

(2) by Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Radix Gentianae, Radix Glycyrrhizae, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Semen Arecae totally seven taste crude drug decoct with water twice, first time adds the water of seven taste crude drug weight 10 times amount, extracts 2 hours; Filter, medicinal residues add the water of seven taste crude drug weight 8 times amount again, extract 1 hour, filter, merge twice filtrate; Be evaporated to the thick paste that 90 DEG C are surveyed relative density 1.35;

(3) in thick paste, add Radix Ginseng Rubra fine powder and starch 300g, granulate, the granule made is put in ebullated dryer, under 70 DEG C of conditions, is dried to dry granule;

(4) add the magnesium stearate of dry particle weight 1%, mixing, tabletting, to obtain final product.

Embodiment 3

The present invention treats the pharmaceutical composition of peptic ulcer by weighing scale: Radix Ginseng Rubra 20g, Radix Et Rhizoma Rhei 20g, Rhizoma Zingiberis Recens 20g, Radix Gentianae 60g, Radix Glycyrrhizae 60g, Rhizoma Cyperi 60g, Rhizoma Atractylodis Macrocephalae 10g and Semen Arecae 10g make as material medicine, and its preparation method is:

(1) first Radix Ginseng Rubra water shower is cleaned, to put in baking oven 85 DEG C and dry, pulverize, cross 100 mesh sieves, obtain Radix Ginseng Rubra fine powder;

(2) by Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Radix Gentianae, Radix Glycyrrhizae, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Semen Arecae totally seven taste crude drug decoct with water twice, first time adds the water of seven taste crude drug weight 11 times amount, extracts 2.5 hours; Filter, medicinal residues add the water of seven taste crude drug weight 9 times amount again, extract 1.5 hours, filter, merge twice filtrate; Be evaporated to the thick paste that 85 DEG C are surveyed relative density 1.38;

(3) in thick paste, add Radix Ginseng Rubra fine powder and starch 400g, granulate, the granule made is put in ebullated dryer, under 80 DEG C of conditions, is dried to dry granule;

(4) add the magnesium stearate of dry particle weight 1%, mixing, tabletting, to obtain final product.

Embodiment 4

The pharmaceutical composition that the present invention treats peptic ulcer is made up of the crude drug of following weighing scale: Radix Ginseng Rubra 10g, Radix Et Rhizoma Rhei 20g, Rhizoma Zingiberis Recens 20g, Radix Gentianae 30g, Radix Glycyrrhizae 60g, Rhizoma Cyperi 30g, Rhizoma Atractylodis Macrocephalae 10g and Semen Arecae 10g;

Its preparation method is:

(1) first Radix Ginseng Rubra water shower is cleaned, to put in baking oven 75 DEG C and dry, pulverize, cross 100 mesh sieves, obtain Radix Ginseng Rubra fine powder;

(2) by Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Radix Gentianae, Radix Glycyrrhizae, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Semen Arecae totally seven taste crude drug decoct with water twice, first time adds the water of seven taste crude drug weight 11 times amount, extracts 2 hours; Filter, medicinal residues add the water of seven taste crude drug weight 7 times amount again, extract 1.5 hours, filter, merge twice filtrate; Be evaporated to the thick paste that 80 DEG C are surveyed relative density 1.40;

(3) in thick paste, add Radix Ginseng Rubra fine powder and starch 275g, granulate, the granule made is put in ebullated dryer, under 80 DEG C of conditions, is dried to dry granule;

(4) add the magnesium stearate of dry particle weight 1%, mixing, tabletting, to obtain final product.

In said medicine:

Radix Ginseng Rubra: sweet, micro-hardship, temperature.Return spleen, lung, heart channel.Have strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, nourishing qi to stop.For weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis; Heart failure, cardiogenic shock.

Pharmacological research shows, Radix Ginseng Rubra has following effect: 1. Radix Ginseng Rubra has excitation to central nervous system and cardiac muscle and blood vessel, and has inhibitory action on the contrary time a large amount of; 2, body is strengthened to the resistance of harmful factor; 3, have the hyperglycemia animal caused because of epinephrine and fall hypoglycemic effect; Improve outside symptom to diabetics decapacitation is conscious, also have slight hypoglycemic activity, and have synergism with islets of langerhans; 4, can promote the gonad function of animal, white mice eats Radix Ginseng Rubra in a small amount, can produce and lift tail phenomenon; 5, at suitable dosage, also can put on weight to rabbit, make the ratio of plasma albumin and globulin increase; 6, hemopoietic organ, is improved the effect of anemia; 7, long-term taking in a small amount, can make reticuloendothelial system can be high.

Radix Et Rhizoma Rhei: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.There is purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.

Pharmacological research shows, Radix Et Rhizoma Rhei has following effect: 1. discharge function Radix Et Rhizoma Rhei has discharge function, and anthraquinone glycoside is that it produces the main component of discharge function, and the effect of dianthracene ketone Sennosides is the strongest, and sequestered Anthraquinones only has faint discharge function; 2, Radix Et Rhizoma Rhei all has antibacterial action to gram-positive bacteria and some gram-negative bacteria. and antibacterial effective ingredient is best with aloe-emodin, emodin and chrysophanic acid effect; 3, give Radix Et Rhizoma Rhei can treat and prevent the hemorrhage of stress gastric ulcer; show as extent of hemorrhage obviously to alleviate; hemorrhagic focus and hemorrhagic focus area obviously reduce; its effect is similar to cimetidine. and the mechanism of rhubarb treatment and pre-ulcer is that it has gastric acid secretion inhibiting, reduces the effect of proteinase activity; 4, emodin can remove the isolated mouse enterospasm caused by acetylcholine, and its spasmolysis comparatively papaverine is strong more than 4 times, but more weak to the spasmolysis of guinea pig trachea; 5, Radix Et Rhizoma Rhei has obvious inhibitory action to inflammation, oral decoct can significantly suppress Oleum Tiglii to cause mouse ear inflammatory edema, rat formaldehyde, Ovum Gallus domesticus album pedal swelling, the granuloma induced by implantation of cotton pellets hypertrophy of Mouse and rat. Rhubarb concoction is to ooze out and the inflammatory process of granulation hyperplasia all has inhibitory action.

Rhizoma Zingiberis Recens: pungent, tepor.Return lung, spleen, stomach warp.There is the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.

Pharmacological research shows, Rhizoma Zingiberis Recens has following effect: 1. Rhizoma Zingiberis Recens can regulate lipid peroxidation in rats, reduces body endoperoxide; 2, cholesterol effect 3, the rat paw edema that carrageenin and 52 hydroxytryptamines (52HT) can be suppressed to cause and hydroderma is reduced; but the swelling caused for Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 or Kallidin I does not affect, point out its mechanisms of anti-inflammatory receptor related with blocking-up 52HT; 4, common in culture medium dermatophytosis, trichophyton, Sabouraudites lanosus tinea barbae, trichophyton acrothesium floccosum have antibacterial and bactericidal action very significantly.

Rhizoma Zingiberis Recens: pungent, tepor.Return lung, spleen, stomach warp.There is the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.

Pharmacological research shows, Rhizoma Zingiberis Recens has following effect: 1. Rhizoma Zingiberis Recens can regulate lipid peroxidation in rats, reduces body endoperoxide; 2, cholesterol effect 3, the rat paw edema that carrageenin and 52 hydroxytryptamines (52HT) can be suppressed to cause and hydroderma is reduced; but the swelling caused for Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 or Kallidin I does not affect, point out its mechanisms of anti-inflammatory receptor related with blocking-up 52HT; 4, common in culture medium dermatophytosis, a trichophyton! A Sabouraudites lanosus! An alpha fungus! Acrothesium floccosum has antibacterial and bactericidal action very significantly.

Radix Gentianae: bitter, cold.Return liver, gallbladder meridian.There is heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.

Pharmacological research shows, Radix Gentianae has following effect: 1. on gastral impact: Radix Gentianae or gentiopicrin can promote gastric juice and gastric acid secretion, causes the Canis familiaris L. of gastric fistula pipe oral, can promote gastric secretion with gentiopicrin, and free hydrochloric acid can be made to increase, appetite is promoted.2. diuresis: Radix Gentianae has obvious diuresis.3. function of gallbladder promoting and hepatoprotective effect: increase bile flow can be shown.4. the effect of couple central nervous system: tinctura gentianae heavy dose has hypotensive effect to anesthetized animal, and can suppress heart, makes decreased heart rate.5. antibacterial action: to root nodule bacteria, escherichia coli, bacillus subtilis, Agrobacterium tumefaciens etc. have effect; To bacillus pyocyaneus, Bacillus proteus, Bacillus typhi, dysentery bacterium, staphylococcus aureus etc. have inhibitory action in various degree.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Pharmacological research shows, Radix Glycyrrhizae has following effect: western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect.

Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.There are promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Pharmacological research shows, Rhizoma Cyperi has following effect: 1. pair smooth muscle effect: Rhizoma Cyperi volatile oil can relax rabbit intestinal smooth muscle, and acetone extract can shrink myenteron caused by anti-acetylcholine, potassium ion.2. function of gallbladder promoting: obviously increase solid contents in bile flow and bile.3. suppress uterus and estrogen-like effects: Rhizoma Cyperi fluid extract is to dog, cat, rabbit, guinea pig in vitro uterus, no matter to be pregnant and unpregnancy all has inhibitory action, make uterine leio muscle relaxation, muscular tension declines, and contractility weakens.4. analgesia, antiinflammatory: cyperol extract can significantly improve the threshold of pain of mice, suppresses carrageenin and formaldehyde to cause rat paw edema.

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.

Pharmacological research shows, the Rhizoma Atractylodis Macrocephalae has following effect: 1. the regulating action of Peritoneal Stomata: the Rhizoma Atractylodis Macrocephalae has the function opening large Peritoneal Stomata significantly, and the open number of Peritoneal Stomata is increased, because the Rhizoma Atractylodis Macrocephalae can regulate and control Peritoneal Stomata strongly, so they have significant treating ascites effect.2. the inhibitory action of pair metabolism activation enzyme: Rhizoma Atractylodis Macrocephalae water extraction brings out the formation of V79 cell micronucleus, and there is inhibitory action in system to metabolism activation enzyme.3. the effect of pair uterine smooth muscle: the ethanol extract of the Rhizoma Atractylodis Macrocephalae and ligroin extraction are to the Spontaneous Contraction of unpregnancy mice isolated uterine and to oxytocin, and the uteri excitation that Herba Leonuri causes shrinks all in significant inhibitory action.4. on the impact of gastrointestinal motility: promote the emptying and gastrointestinal propulsive movement effect of Mouse Stomach.5. pair lymphocytic regulating action: have regulating action with external to mouse spleen lymphocyte in Rhizoma Atractylodis polysaccharide PAM body.6. immunoregulation effect: immunosuppressant animal splenocyte In vitro culture survival rate can be improved, can lymphocyte life span be extended.7. the Rhizoma Atractylodis Macrocephalae also have diuresis, blood sugar lowering, strong, anticoagulant, antibacterial, the pharmacological action such as to protect the liver.

Semen Arecae: bitter, pungent, temperature.Return stomach, large intestine channel.There is killing insect and eliminating accumulation, sending down the abnormal ascending QI, row water, preventing the attack (or recurrence) of malaria.For cestode, ascarid, fasciolopsiasis buski, abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, malaria.

Pharmacological research shows, Semen Arecae has following effect: 1. go out spiral shell: arecoline and the conbined usage such as plant drug for exterminating oncomelania snail phytolaccatoxin or chemical drug for exterminating oncomelania snail five ammonia phenol sodium, significantly can reduce the dosage of the two.2. anthelmintic, parasite killing: have obvious inhibitory action to trichomonal vaginitis, press down worm rate and reach 81% ~ 100%.3. antibacterial: to be obvious bacteriostasis to each experimental strain.4. short gastrointestinal motility: the effect of significant short functional dyspepsia rat stomach smooth muscle contraction.

The scientific and reasonable allotment drug component of the present invention, has the advantage that curative effect is high, have no side effect.The result of clinical observation of the present invention is as follows:

1, tCM syndrome diagnostic criteria:

Epigastric distending pain, two side of body feeling of distension and oppression, indistinctly, desire for warm and being pressed, whenever cold or tired easy outbreak or increase the weight of, pain of empty stomach weight, obtain food alleviation of pain, abdominal distention after meal, fatigue and weakness, spiritlessness and sparing of words, aversion to cold and cold limbs, the stool pool is thin in stomachache.

2, inclusive criteria

Meet peptic ulcer diagnostic criteria and TCM syndrome diagnostic criteria.In 1 week, fibrescope turns out to be ulcer active stage, ulcer diameter person between 2 ~ 3mm.

3, patient's exclusion standard

Endoscope turns out to be giving a farfetched interpretation property ulcer, stomach bottom ulcer, gastric ulcer merging severe dysplasia person;

There is complication in 30 days before the test and carry out operator;

There is the gastric and duodenal ulcers of cause specific, as gastrinoma, hepatitis interstitialis chronica etc.;

The women of gestation and preparation gestation, women breast-feeding their children; Allergic constitution or to multi-medicament allergy sufferers and other unaccommodated patients.

4, therapeutic scheme

Oral the present invention, three times on the one, a 1-2g.Treating 1 week is a course for the treatment of, continuously treatment 4 weeks, statistics curative effect.

5, curative effect determinate standard:

Cure: patient's ulcer surface and around inflammation all disappear.

Effective: patient's ulcer disappears, and still has inflammation, does not reach arm's length standard.

Effective: patient's ulcer surface reduces more than 50%, and the state of an illness makes moderate progress.

Invalid: patient's ulcer surface reduces not as good as 50% or without any improvement.

6, curative effect of medication observes situation:

Drug therapy 152 people of the present invention, healing person 74 people, effective person 44 people, responder: 20 people, nonresponder 14 people, effective percentage 91%, and at treatments period, there are no untoward reaction, have no side effect, to healing person, follow up a case by regular visits to after 2 years, there are no recidivist.

Model case:

Zhang: man, 45 years old, people from Dancheng County, Henan Province, suffer from gastric ulcer 4 years, long-term taking chemotherapy, had certain effect, but can not fully recover, and side effect is large, and through Drug therapy of the present invention, 2 months take effect, recovery from illness in 4 months.

Wang: man, 47 years old, century-old Kang Xin Pharmaceutical employee, suffer from gastric ulcer 2 years, frequent flatulence pain, belch, acid regurgitation water etc., through Drug therapy of the present invention, 2 months took effect, recovery from illness in 5 months.

Liu: female, 38 years old, people from Dancheng County, Henan Province, suffered from gastric ulcer 3 years, heartburn, xerostomia is bitter, pantothenic acid, constipation etc., through Drug therapy of the present invention, 1 month takes effect, recovery from illness in 3 months.

In sum, the present invention treats the medicine composite for curing Be very effective of peptic ulcer, and effective percentage is up to more than 91%, and be the innovation on treatment peptic ulcer medicine, have very strong practical clinical and be worth, economic and social benefit is huge.

Claims (5)

1. treat the pharmaceutical composition of peptic ulcer for one kind, it is characterized in that, be made up of the crude drug of following weighing scale: Radix Ginseng Rubra 10 ~ 20g, Radix Et Rhizoma Rhei 10 ~ 20g, Rhizoma Zingiberis Recens 10 ~ 20g, Radix Gentianae 30 ~ 60g, Radix Glycyrrhizae 30 ~ 60g, Rhizoma Cyperi 30 ~ 60g, the Rhizoma Atractylodis Macrocephalae 5 ~ 10g and Semen Arecae 5 ~ 10g.

2. the pharmaceutical composition for the treatment of peptic ulcer according to claim 1, is characterized in that, by weighing scale: Radix Ginseng Rubra 10g, Radix Et Rhizoma Rhei 10g, Rhizoma Zingiberis Recens 10g, Radix Gentianae 30g, Radix Glycyrrhizae 30g, Rhizoma Cyperi 30g, Rhizoma Atractylodis Macrocephalae 5g and Semen Arecae 5g make as material medicine.

3. the pharmaceutical composition for the treatment of peptic ulcer according to claim 1, is characterized in that, by weighing scale: Radix Ginseng Rubra 15g, Radix Et Rhizoma Rhei 15g, Rhizoma Zingiberis Recens 15g, Radix Gentianae 45g, Radix Glycyrrhizae 45g, Rhizoma Cyperi 45g, Rhizoma Atractylodis Macrocephalae 7.5g and Semen Arecae 7.5g make as material medicine.

4. the pharmaceutical composition for the treatment of peptic ulcer according to claim 1, is characterized in that, by weighing scale: Radix Ginseng Rubra 20g, Radix Et Rhizoma Rhei 20g, Rhizoma Zingiberis Recens 20g, Radix Gentianae 60g, Radix Glycyrrhizae 60g, Rhizoma Cyperi 60g, Rhizoma Atractylodis Macrocephalae 10g and Semen Arecae 10g make as material medicine.

5. the preparation method of the pharmaceutical composition of the treatment peptic ulcer described in claim 1-4 any one, it is characterized in that, step is as follows:

(1) first Radix Ginseng Rubra water shower is cleaned, to put in baking oven 75-85 DEG C and dry, pulverize, cross 100 mesh sieves, obtain Radix Ginseng Rubra fine powder;

(2) by Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Radix Gentianae, Radix Glycyrrhizae, Rhizoma Cyperi, the Rhizoma Atractylodis Macrocephalae, Semen Arecae totally seven taste crude drug decoct with water twice, first time adds the water of seven taste crude drug weight 9-11 times amount, extracts 1.5-2.5 hour; Filter, medicinal residues add the water of seven taste crude drug weight 7-9 times amount again, extract 1-1.5 hour, filter, merge twice filtrate; Be evaporated to the thick paste that 80 DEG C ~ 90 DEG C are surveyed relative density 1.35 ~ 1.40;

(3) in thick paste, add Radix Ginseng Rubra fine powder and starch 200g-400g, granulate, the granule made is put in ebullated dryer, under 60 ~ 80 DEG C of conditions, is dried to dry granule;

(4) add the magnesium stearate of dry particle weight 1%, mixing, tabletting, to obtain final product.