CN104189691A - Pharmaceutical composition and pharmaceutical preparation and application thereof - Google Patents
Pharmaceutical composition and pharmaceutical preparation and application thereof Download PDFInfo
- Publication number
- CN104189691A CN104189691A CN201410440494.5A CN201410440494A CN104189691A CN 104189691 A CN104189691 A CN 104189691A CN 201410440494 A CN201410440494 A CN 201410440494A CN 104189691 A CN104189691 A CN 104189691A
- Authority
- CN
- China
- Prior art keywords
- content
- radix
- brown
- parched
- pharmaceutical preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials: rhizoma cyperi, licorice, elecampane, Rheum palmatum L., galangal, Raphanus sativus L., rructus evodiae, wolfiporia cocos, dried tangerine or orange peel, betel nut slices, white paeony root, bletilla, dark malt, scorched hawthorn fruit and scorched medicated leaven, wherein based on 100 weight parts of rhizoma cyperi, the content of the licorice, Rheum palmatum L. and elecampane is respectively and independently 100-150 weight parts; the content of the galangal, Raphanus sativus L. and rructus evodiae is respectively and independently 100-300 weight parts; the content of the Rheum palmatum L. and dried tangerine or orange peel is respectively and independently 100-350 weight parts; the content of the betel nut slices, white paeony root and bletilla is respectively and independently 100-380 weight parts; and the content of the dark malt, scorched hawthorn fruit and scorched medicated leaven is respectively and independently 100-350 weight parts. The invention also provides a pharmaceutical preparation containing the pharmaceutical composition, as well as application of the pharmaceutical preparation and the pharmaceutical composition. When the pharmaceutical composition or pharmaceutical preparation provided by the invention is taken, patients suffering from stomach illness can be effectively treated, so that uncomfortable symptoms of the patients suffering from stomach illness are obviously improved.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, the pharmaceutical preparation of being prepared by this pharmaceutical composition, and the application in the medicine for the preparation for the treatment of gastropathy of described pharmaceutical composition, described pharmaceutical preparation.
Background technology
Along with the develop rapidly of modern social economy, the improving constantly of living standards of the people, the incidence rate of gastropathy is also along with the trend that occurs rising year by year.The traditional Chinese medical science thinks, be mainly because: (1) disorder of emotion: " the main think of of spleen ", " worry impairing spleen ".The traditional Chinese medical science before more than 2,000 years, just recognized people's the mental status and digestive function relation very large.Be worried angry, for a long time strongly fragrant puzzled, injure in liver, depression of liver-QI perverse and unreasonable manner is violated stomach, the venation of the stomach of burning, and network removing blood stasis goes out; (2) eating and drinking without temperance: < < Yu Bo doctor passes > > side: " cause a disease by, how because of self-indulgent food, it is sad to like, and throws off restraint the hot wine of drink and decocts and dial, multiple meal is cold, cool, raw, cold; Towards wine cup drink at dusk, accumulate over a long period, from strongly fragrant one-tenth expectorant, phlegm-fire decocts, and blood is absurd row also, and expectorant blood is assorted mutually, hinders lifting, thus gastralgia, acid regurgitation belch, noisy nauseating; (3) physical factors: " constitution with insufficiency of YANG, excessive phlegm is wet mutually ", being seen ulcer is also that yang deficiency body constitution is more clinically, deficiency of YIN body constitution is less.Because plain body deficiency of spleen-YANG is cold, failure of the spleen to transport and transform, zang-viscera disease involving fu-viscera, stomach-QI being unable to descend normally, gastral cavilty is had a pain.In addition, why extrinsic factor can bring out primary disease as eating cold and uncooked food excessively, affection of exogenous wind-cold, overstrain etc., all with usually have a delicate constitution, particularly weakness of the spleen and stomach has substantial connection; (4) climate change: " cold visitor is in the intestines and stomach, faints on contrary, therefore pain and vomitting." refer to catch cold and can facilitate the outbreak of gastropathy.Can see clinically, the outbreak of gastropathy with flu, be subject to it is attacked by the cold and evil relevant, also can find according to the relevent statistics, the sickness rate of gastropathy changes along with the variation of weather, primary disease in the winter time and cold season autumn Mo multiple.
People's the healthy living of giving occurred frequently of gastropathy has caused serious impact, therefore, develop a kind of can invigorating the spleen and regulating the stomach, soothing liver-QIization stagnant to gastropathy, have the pharmaceutical preparation of good therapeutic effect imperative.
Summary of the invention
The pharmaceutical preparation that the object of this invention is to provide a kind of pharmaceutical composition and be prepared from by this pharmaceutical composition, can patients with gastric disease being played to invigorating the spleen and regulating the stomach, the stagnant effect of soothing liver-QIization, thereby (for example effectively prevent and/or treat gastritis, the chronic gastritis such as chronic atrophic gastritis and duodenal bulbar ulcer), and alleviate the stomachache with cool feeling caused by gastritis, abdominal distention, belch, poor appetite, fear of cold and the symptom such as unable.
To achieve these goals, on the one hand, the invention provides a kind of pharmaceutical composition, wherein, this pharmaceutical composition is prepared from by following raw material: Rhizoma Cyperi, Radix Glycyrrhizae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Rhizoma Alpiniae Officinarum, Radix Raphani, Fructus Evodiae, Fang Ling, Pericarpium Citri Reticulatae, bulky, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown), wherein, the Rhizoma Cyperi of 100 weight portions of take is benchmark, Radix Glycyrrhizae, the content of Radix Et Rhizoma Rhei and the Radix Aucklandiae is 100-150 weight portion independently of one another, Rhizoma Alpiniae Officinarum, the content of Radix Raphani and Fructus Evodiae is 100-300 weight portion independently of one another, the content of Fang Ling and Pericarpium Citri Reticulatae is 100-350 weight portion independently of one another, bulky, the content of the Radix Paeoniae Alba and the Pseudobulbus Bletillae (Rhizoma Bletillae) is 100-380 weight portion independently of one another, Fructus Hordei Germinatus (parched to brown), the content of Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown) is 100-350 weight portion independently of one another.
On the other hand, the present invention also provides a kind of pharmaceutical preparation, and described pharmaceutical preparation contains active component and pharmaceutically acceptable adjuvant alternatively, and wherein, described active component is pharmaceutical composition as above.
On the one hand, the present invention also provides pharmaceutical composition as above again, the application of pharmaceutical preparation as above in the medicine for the preparation for the treatment of gastropathy.
By taking pharmaceutical composition provided by the invention or pharmaceutical preparation, as shown in the Examples, can effectively to patients with gastric disease, treat, and obtain obvious improvement up to the malaise symptoms of 97.5% patients with gastric disease.
Other features and advantages of the present invention partly in detail are described the specific embodiment subsequently.
The specific embodiment
Below the specific embodiment of the present invention is elaborated.Should be understood that, the specific embodiment described herein only, for description and interpretation the present invention, is not limited to the present invention.
On the one hand, the invention provides a kind of pharmaceutical composition, wherein, this pharmaceutical composition is prepared from by following raw material: Rhizoma Cyperi, Radix Glycyrrhizae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Rhizoma Alpiniae Officinarum, Radix Raphani, Fructus Evodiae, Fang Ling, Pericarpium Citri Reticulatae, bulky, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown), wherein, the Rhizoma Cyperi of 100 weight portions of take is benchmark, Radix Glycyrrhizae, the content of Radix Et Rhizoma Rhei and the Radix Aucklandiae is 100-150 weight portion independently of one another, Rhizoma Alpiniae Officinarum, the content of Radix Raphani and Fructus Evodiae is 100-300 weight portion independently of one another, the content of Fang Ling and Pericarpium Citri Reticulatae is 100-350 weight portion independently of one another, bulky, the content of the Radix Paeoniae Alba and the Pseudobulbus Bletillae (Rhizoma Bletillae) is 100-380 weight portion independently of one another, Fructus Hordei Germinatus (parched to brown), the content of Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown) is 100-350 weight portion independently of one another.
The content of each composition in described pharmaceutical composition exists, the Rhizoma Cyperi of 100 weight portions of take is benchmark, Radix Glycyrrhizae, the content of Radix Et Rhizoma Rhei and the Radix Aucklandiae is 110-140 weight portion independently of one another, Rhizoma Alpiniae Officinarum, the content of Radix Raphani and Fructus Evodiae is 150-200 weight portion independently of one another, the content of Fang Ling and Pericarpium Citri Reticulatae is 150-250 weight portion independently of one another, bulky, the content of the Radix Paeoniae Alba and the Pseudobulbus Bletillae (Rhizoma Bletillae) is 150-300 weight portion independently of one another, Fructus Hordei Germinatus (parched to brown), the content of Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown) is 120-280 weight portion independently of one another, preferable range in time, prepared pharmaceutical composition is better to the therapeutic effect of gastropathy.
According to the present invention, the state of each raw material for the preparation of aforementioned pharmaceutical compositions is had no particular limits, for example, can be pulverulence, can be also the liquid condition boiling, these those skilled in the art all can select according to practical situation.According to the present invention, the described raw material of preparing described compositions is preferably pulverulence, and described powder is preferably and can passes through the siftage of 80-150 mesh sieve, more preferably can pass through the siftage of 100-120 mesh sieve.
Rhizoma Cyperi is the dry rhizome of sedge dried tuber (Cyperus rotundus L.).After harvesting, remove feeler and impurity, cut sheet or pulverize, put in boiling water, slightly boil or steam after dry, or burn and directly dry afterwards.
This product is spindle more, and some summaries are crooked.Surface sepia or pitchy, have vertical wrinkle, and have the slightly link of protuberance, has brown feeler and the fibrous root mark of break of not Ex-all on joint; Person is more smooth to remove feeler, and link is not obvious.Matter is hard, through steaming and decocting person's section yellowish-brown or rufous, and cutin sample; Sun-dried person is broken pale complexion and is shown mealiness, and endodermis ring grain is obvious, and center pillar color is darker, and point-like vascular bundle is dispersed in.Gas is fragrant, mildly bitter flavor.
Radix Glycyrrhizae, formal name used at school Glycyrrhiza uralensis Fisch., has another name called Glycyrrhiza uralensis Fisch., and herbaceos perennial belongs to pulse family.Spring, Qiu Erji excavate, and remove fibrous root, dry.
Licorice is cylindrical, and crust degree of tightness differs, the brown or taupe brown of surface red, and tool is vertical wrinkle, rill, hole skin and sparse radicula trace significantly.Matter is solid, and section shows slightly fibroid, yellow-white, and mealiness, cambium ring is obvious, ray irradiation shape, what have has a crack.Rhizome is cylindrical, and there is bud trace on surface, and there is marrow at section middle part.Feeble QI, taste is sweet and special.
The Radix Aucklandiae: the common name of feverfew Saussurea lappa Clarke and Radix Vladimiriae.Saussurea lappa Clarke (formal name used at school: Saussurea costus), have another name called Radix Aucklandiae (Radix Vladimiriae) or Radix Aristolochiae, belong to Compositae Genus Saussurea.Radix Vladimiriae (formal name used at school: Dolomiaea souliei) being the plant of Compositae Dolomiaea, is all peculiar wild plants of China, not yet by artificial introducing and planting.The rhizome of this two kind of plant is all important Chinese herbal medicine.Autumn, two seasons of winter excavate, and remove silt and fibrous root, cutting, and large vertical profile again becomes lobe, after being dried, hits rough bark.Gas perfume (or spice) is special, mildly bitter flavor.
Radix Et Rhizoma Rhei: be the rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Formal name used at school: before the withered or inferior spring germination of Rheum palmatum L. autumn Mo stem and leaf, excavate, remove radicula, scrape off crust, valve cutting or section, rope is worn bunchiness and is dried or convection drying.
This product is that class is cylindrical, conical, oval or irregular bulk.The surperficial yellowish-brown of the person that eliminates crust is to rufous, and the visible off-white color reticular texture having and punctate opacity of the cornea (special-shaped vascular bundle) are dispersed in, residual crust sepia, many tools rope hole and thick wrinkle.Matter is solid, and You center is slightly soft, the light red brown or yellowish-brown of section, aobvious graininess; Rhizome marrow is broad, has punctate opacity of the cornea circular row or is dispersed in; Root woody part is flourishing, the radial texture of tool, and stratification ring is obvious, without punctate opacity of the cornea.Gas delicate fragrance, bitter in the mouth is and micro-puckery, and that chews sticks to one's teeth, and has sand feeling.
Rhizoma Alpiniae Officinarum: this product is the dry rhizome of zingiberaceous plant Alpinia officinarum Hance.At the beginning of autumn late summer, excavate, remove fibrous root and residual scale, clean, cutting, dries.
This product is cylindrical, how crooked, has branch.Surface brownish red, to crineous, has fine and closely woven vertical wrinkle and the wavy link of taupe brown, and one side has circular root trace.Matter is tough and tensile, frangibility not, and section taupe brown or rufous, fibroid, center pillar accounts for 1/3.Gas is fragrant, and acrid in the mouth is peppery.
Radix Raphani: be the mature seed of crucifer Radix Raphani, Latin is called Raphanus sativus L.Tap plant during fruit maturation summer, dries, and rubs seed, removes impurity.
This product is class oval or ellipse, slightly flat.Surface yellowish-brown, rufous or taupe brown.There is the circular hilum of dark-brown one end, and a side has several longitudinal furrows.Plant skin thin and crisp, yellow-white, has oiliness.Feeble QI, lightly seasoned, micro-toil.
Fructus Evodiae: be the immaturity dry fruit of rutaceae shrub or dungarunga Fructus Evodiae (the former plant Evodia of medical material Fructus Evodiae rutaecarpa (Juss.) Benth.) and mutation thereof.
Fructus Evodiae, dungarunga or shrub, the dark violet redness of twig, same by sallow or red rust color fine hair with tender shoots, or thin undercoat.Tender fruit is Chinese medicine Fructus Evodiae after brewed airing, claims again Fructus Evodiae.Leaf has lobule, and lobule is as thin as ground paper matter, avette, ellipse or lanceolar, rachis bottom less.Inflorescence top is raw; The flower of staminate inflorescence is estranged each other, and spending of female inflorescence is intensive or estranged.
Fang Ling (Wolfiporia cocos): the dry sclerotia of Shi Ni shelf fungus section fungus Poria, often colonize on pinaster root, shape is as Rhizoma Dioscoreae esculentae, spherical, crust light brown or pitchy, inner pink colour or white, be called Poria or Poria after refining.
Mostly be irregular bulk, spherical, flat, Long Circle or oblong etc., not of uniform size, little person is as fist.The light taupe brown of epidermis or pitchy, be warty shrinkage, and inner white is slightly with pink, countless mycelia, consists of.Sporophore is calm, and peristoma is tooth slightly; Sexual generation is difficult for seeing, cellular, the crust of common attached sclerotium and giving birth to, first white, after change gradually light brown into, polygon is made in hole, load is bar-shaped, basidiospore is oval to cylindrical, flexing slightly, one end point, level and smooth, colourless.There is special foul smell.
Pericarpium Citri Reticulatae: the peel of dicotyledon medicine rutaceae Citrus sinensis (L.) Osbeck or Citrus aurantium L..
Bulky: be the seed of babassu Semen Arecae (Semen Arecae).
The Radix Paeoniae Alba: the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Summer, Qiu Erji excavate, and clean, and remove end to end and radicula, put after removing crust or peeling after boiling in boiling water and boil, dry.
This product is cylindrical, and straight or slightly crooked, two ends are truncate.Surface off-white color or light brown red, bright and clean or have vertical wrinkle and radicula trace, occasionally there is remaining sepia crust.Matter is solid, frangibility not, and section is more smooth, off-white color or micro-band brownish red, cambium ring is obvious, ray irradiation shape.Feeble QI, mildly bitter flavor, acid.
The Pseudobulbus Bletillae (Rhizoma Bletillae) (formal name used at school: Bletilla striata) have another name called Lian Jicao, sweet, give free of charge, indocalamus orchid, Zhu Lan, Rhizoma Bletillae, purple a species of orchid, hundred large bamboo hats with a conical crown and broad brim.Two seasons of autumn in summer excavate, and remove residual stem and fibrous root, clean, and put boiling water boiling to without the white heart, remove crust, dry, and section is raw to be used.
Rhizome is slightly irregular oblateness or rhombus.Surface canescence or yellow-white, have fine wrinkle, has protruding stem trace above, also has the vestige that connects another tuber below; Centered by stem trace, several sepia concentricity, the mark of fibrous root of residual brown point-like on ring.Matter is hard, not frangibility.Section off-white color, translucent, cutin sample, is dispersed in point-like vascular bundle as seen.Coarse powder is met water and is expanded, and has remarkable stick-slip sense, and infusion is colloid sample.Odorless, bitter in the mouth, the toughness of chewing.Take individual large, full, color is white, translucent, the solid person of matter is as good.
Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown), claim again JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata).
Through barley germination, form, Fructus Hordei Germinatus is put to pot interior micro-stir-fry to yellow, spray clear water, taking-up is dried, and is Fructus Hordei Germinatus (parched to brown).Fructus Crataegi section is dried, and putting and frying with high heat extremely outer wrinkly face brown, inner yellowish-brown in pot is degree, sprays clear water, and taking-up is dried, and is Fructus Crataegi (parched to brown).Whole wheat flour and other drug (Herba Artemisiae Annuae, Herba Xanthii, the buds such as Herba polygoni hydropiperis, Semen Armeniacae Amarum, Semen Phaseoli) mix the processed goods form by fermentation, get Massa Medicata Fermentata and put in pot, to fry to appearance and be coke black, inner coke yellow, take out, and spray the water that disappears, and cool, and are Massa Medicata Fermentata (parched to brown).
Source to above-mentioned various raw materials in the present invention has no particular limits, and for example, can on market, buy the product having cooked, and also can obtain by conventional concocting method, for example, can make by raw material is dried and is ground.Dry method can, for drying or naturally drying, be preferably nature and dry.The method of grinding can be the Ginding process of field of Chinese medicines routine, and the condition optimization of grinding makes described raw material can pass through the powder of 80-150 object sieve aperture, preferably can pass through 100-120 object sieve aperture.
According to the present invention, the method for being prepared described compositions by above raw material has no particular limits, and can, for the method for the pharmaceutical compositions of this area routine, for example, after can directly mixing, obtain.
Second aspect, the present invention also provides a kind of pharmaceutical preparation, and this pharmaceutical preparation contains active component, and pharmaceutically acceptable adjuvant alternatively, and wherein, described active component is above-described pharmaceutical composition.
According to the present invention, can by described active component and alternatively pharmaceutically acceptable adjuvant be prepared into any type of pharmaceutical preparation.For example, can be pill, capsule or unguentum.Described pharmaceutically acceptable adjuvant can specifically be selected according to the dosage form of prepared pharmaceutical preparation.And well known to a person skilled in the art, adding of described adjuvant can't have a negative impact to the drug effect of pharmaceutical preparation.
When pharmaceutical preparation of the present invention is capsule, described pharmaceutical preparation comprises capsule shells and is filled in the described active component in capsule shells.
According to the present invention, the preparation method of described capsule has no particular limits, it can be the preparation method of this area routine, for example, can the above pharmaceutical composition as active component directly be incapsulated in shell, wherein, described capsule shells can be by commercially available, for example, can be the hard capsule case of suitable size of national related medical sanitary standard of meeting of this area routine.In every capsules, the amount of active component is preferably 0.45-0.5g.
When described pharmaceutical preparation is pill or unguentum, described pharmaceutical composition contains described active component and pharmaceutically acceptable adjuvant.The gross weight of pharmaceutical preparation of take is benchmark, and the content of described active component can be 10-90 % by weight, is preferably 30-50 % by weight, and the content of described adjuvant can be 10-90 % by weight, is preferably 50-70 % by weight.
According to the present invention, described adjuvant is preferably Mel, and described Mel can be commercially available various Mel.
According to the present invention, the preparation method of described pill can comprise: the pharmaceutical composition providing is mixed with adjuvant as above and molding.The temperature of described mixing can be 100-130 ℃, is preferably 105-110 ℃, and the time of mixing can be 10-60 minute.The method of described molding can adopt the conventional forming method for the preparation of pill, for example, the medicine piece being mixed to form can be put into pellet processing machine and become ball.Preferably with doctor's pellet processing machine, make the pill of about 0.2-0.5 gram.
According to the present invention, the preparation method of described unguentum can comprise: pharmaceutical composition as above and adjuvant are mixed and sealed.Time those skilled in the art of described sealing can adjust voluntarily according to practical situation, for example, can be 4-6 days.
On the one hand, the present invention also provides pharmaceutical composition as above again, the application of pharmaceutical preparation as above in the medicine for the preparation for the treatment of gastropathy.
Described gastropathy can be common various gastropathy, for example, can be gastritis, comprises the chronic gastritiss such as duodenal bulbar ulcer, chronic atrophic gastritis, and alleviates by the caused stomachache with cool feeling of chronic gastritis, abdominal distention, belch, poor appetite, fear of cold and the symptom such as unable.
Below will describe the present invention by embodiment.
In following examples and comparative example, the processing method of raw material used is as follows.
By Rhizoma Cyperi, Radix Glycyrrhizae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Rhizoma Alpiniae Officinarum, Radix Raphani, Fructus Evodiae, Fang Ling, Pericarpium Citri Reticulatae, bulky, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown), after drying, be ground to 120 object powder respectively.
Capsule shells for the production of capsule in following examples and comparative example is purchased from Zhejiang Lv Jian capsule company limited model, to be the snap fit capsule of 1# palm fibre white 2225101.
Table 1
| ? | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Chinese medicine composition numbering | A1 | A2 | A3 | A4 | A5 |
| Rhizoma Cyperi | 100 | 100 | 100 | 100 | 100 |
| Radix Glycyrrhizae | 110 | 120 | 140 | 100 | 150 |
| The Radix Aucklandiae | 110 | 120 | 140 | 100 | 150 |
| Radix Et Rhizoma Rhei | 110 | 120 | 140 | 100 | 150 |
| Rhizoma Alpiniae Officinarum | 150 | 180 | 200 | 100 | 300 |
| Radix Raphani | 180 | 200 | 150 | 300 | 100 |
| Fructus Evodiae | 200 | 160 | 150 | 100 | 300 |
| Fang Ling | 180 | 150 | 250 | 100 | 350 |
| Pericarpium Citri Reticulatae | 150 | 250 | 200 | 350 | 100 |
| Bulky | 200 | 300 | 150 | 100 | 380 |
| The Radix Paeoniae Alba | 300 | 150 | 300 | 300 | 100 |
| The Pseudobulbus Bletillae (Rhizoma Bletillae) | 150 | 250 | 300 | 100 | 300 |
| Fructus Crataegi (parched to brown) | 210 | 120 | 280 | 100 | 350 |
| Fructus Hordei Germinatus (parched to brown) | 120 | 280 | 200 | 250 | 100 |
| Massa Medicata Fermentata (parched to brown) | 180 | 120 | 280 | 100 | 350 |
Embodiment 1-5
Embodiment 1-5 is for the preparation of the pharmaceutical composition that the invention provides thing.
According to the consumption shown in table 1 (all in weight portion), each raw material is mixed, make respectively compositions A1-A5.
Comparative example 1
This comparative example is for the preparation of pharmaceutical composition provided by the invention.
According to the method pharmaceutical compositions of embodiment 1, different, in described pharmaceutical composition, do not contain Rhizoma Cyperi, remaining other compositions are on average shared the amount of the Rhizoma Cyperi of minimizing.Make compositions E1.
Embodiment 6-10
Embodiment 6-7 is used for illustrating preparation capsule provided by the invention.
The pharmaceutical composition A 1-A5 respectively being prepared by 0.5g embodiment 1-5 joins in capsule shells.Make capsule B1-B5.
Embodiment 11-15
Embodiment 11-15 is used for illustrating preparation pill provided by the invention.
Mel is heated to 110 ℃, and the Chinese medicine composition A1-A5 then respectively being prepared by embodiment 1-5 joins that in Mel, (weight ratio of A1-A5 and Mel is 1:1.2, endures 20 minutes at 110 ℃.Then after being naturally cooled to 25 ℃, joining in pellet processing machine and make ball, the weight of every ball is 0.37 gram, obtains pill C1-C5.
Embodiment 16-20
Embodiment 16-20 is used for illustrating preparation unguentum provided by the invention.
The pharmaceutical composition A 1-A5 respectively being prepared by embodiment 1-5 joins in Mel, is mixed into cream, and at room temperature in sealed container, keeps can using for 5 days, obtains unguentum D1-D5.
Comparative example 2
For the capsule of preparing reference is described.
Method according to embodiment 6 is prepared capsule, different, and the pharmaceutical composition using is E1, obtains capsule F1.
Comparative example 3
For the pill of preparing reference is described.
Method according to embodiment 11 is prepared pill, different, and the pharmaceutical composition using is E1, obtains pill G1.
Comparative example 4
For the unguentum of preparing reference is described.
Method according to embodiment 16 is prepared unguentum, different, and the pharmaceutical composition using is E1, obtains unguentum H1.
Test case
Select 720 to there is the men and women patient of gastropathy in various degree and (or suffer from duodenal bulbar ulcer or suffer from chronic atrophic gastritis, there is stomachache with cool feeling, abdominal distention, belch, poor appetite, fear of cold and the symptom such as unable), patient's age is at 20-80 between year, be divided at random 18 treatment groups (every group of 40 patients, the patient of every kind of symptom all has).Wherein, 6 treatment groups are taken respectively capsule B1-B5 and F1, instructions of taking is that every day, sooner or later each was once, each 5, boiled water is oral, 3 weeks observing effects after taking medicine, with take medicine before compare, what symptom disappeared completely is labeled as zero, and symptom obviously alleviates is labeled as △, and symptom is not improved is labeled as *; 6 treatment groups are taken respectively pill C1-C5 and G1, instructions of taking be every day sooner or later each once, each 8 balls, boiled water is oral, observing effect after 100 days, with take medicine before compare, what symptom disappeared completely is labeled as zero, and symptom obviously alleviates is labeled as △, and symptom is not improved is labeled as *; Other 6 treatment groups are taken respectively unguentum D1-D5 and H1, instructions of taking be every day sooner or later each once, each one, boiled water is oral, observing effect after 100 days, with take medicine before compare, what symptom disappeared completely is labeled as zero, and symptom obviously alleviates is labeled as △, and symptom is not improved is labeled as *; The therapeutic effect of 15 treatment groups is as shown in table 2.
Table 2
By table 2, can find out, than the pharmaceutical preparation in comparative example 2-4, the pharmaceutical preparation that adopts pharmaceutical composition of the present invention to prepare, the disease of stomach that can effectively treat patient, and when content is in preferable range, curative effect is better.
More than describe the preferred embodiment of the present invention in detail; but the present invention is not limited to the detail in above-mentioned embodiment, within the scope of technical conceive of the present invention; can carry out multiple simple variant to technical scheme of the present invention, these simple variant all belong to protection scope of the present invention.
It should be noted that in addition each the concrete technical characterictic described in the above-mentioned specific embodiment, in reconcilable situation, can combine by any suitable mode.For fear of unnecessary repetition, the present invention is to the explanation no longer separately of various possible compound modes.
In addition, between various embodiment of the present invention, also can carry out combination in any, as long as it is without prejudice to thought of the present invention, it should be considered as content disclosed in this invention equally.
Claims (10)
1. a pharmaceutical composition, it is characterized in that, this pharmaceutical composition is prepared from by following raw material: Rhizoma Cyperi, Radix Glycyrrhizae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Rhizoma Alpiniae Officinarum, Radix Raphani, Fructus Evodiae, Fang Ling, Pericarpium Citri Reticulatae, bulky, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown), wherein, the Rhizoma Cyperi of 100 weight portions of take is benchmark, Radix Glycyrrhizae, the content of Radix Et Rhizoma Rhei and the Radix Aucklandiae is 100-150 weight portion independently of one another, Rhizoma Alpiniae Officinarum, the content of Radix Raphani and Fructus Evodiae is 100-300 weight portion independently of one another, the content of Fang Ling and Pericarpium Citri Reticulatae is 100-350 weight portion independently of one another, bulky, the content of the Radix Paeoniae Alba and the Pseudobulbus Bletillae (Rhizoma Bletillae) is 100-380 weight portion independently of one another, Fructus Hordei Germinatus (parched to brown), the content of Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown) is 100-350 weight portion independently of one another.
2. pharmaceutical composition according to claim 1, wherein, the Rhizoma Cyperi of 100 weight portions of take is benchmark, the content of Radix Glycyrrhizae, Radix Et Rhizoma Rhei and the Radix Aucklandiae is 110-140 weight portion independently of one another, the content of Rhizoma Alpiniae Officinarum, Radix Raphani and Fructus Evodiae is 150-200 weight portion independently of one another, the content of Fang Ling and Pericarpium Citri Reticulatae is 150-250 weight portion independently of one another, the content of bulky, the Radix Paeoniae Alba and the Pseudobulbus Bletillae (Rhizoma Bletillae) is 150-300 weight portion independently of one another, and the content of Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown) is 120-280 weight portion independently of one another.
3. pharmaceutical composition according to claim 1 and 2, wherein, Rhizoma Cyperi, Radix Glycyrrhizae, the Radix Aucklandiae, Radix Et Rhizoma Rhei, Rhizoma Alpiniae Officinarum, Radix Raphani, Fructus Evodiae, Fang Ling, Pericarpium Citri Reticulatae, bulky, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown) and Massa Medicata Fermentata (parched to brown) are the powder of sieve aperture that can be by 80-150 mesh sieve.
4. a pharmaceutical preparation, described pharmaceutical preparation contains active component and pharmaceutically acceptable adjuvant alternatively, it is characterized in that, and described active component is the pharmaceutical composition described in any one in claim 1-3.
5. pharmaceutical preparation according to claim 4, wherein, described pharmaceutical preparation is capsule, described pharmaceutical preparation comprises capsule shells and is filled in the described active component in capsule shells.
6. pharmaceutical preparation according to claim 4, wherein, described pharmaceutical preparation is pill or unguentum, described pharmaceutical composition contains described active component and pharmaceutically acceptable adjuvant.
7. pharmaceutical preparation according to claim 6, wherein, the gross weight of described pharmaceutical preparation of take is benchmark, and the content of described active component is 10-90 % by weight, and the content of described adjuvant is 10-90 % by weight.
8. pharmaceutical preparation according to claim 7, wherein, the gross weight of described pharmaceutical preparation of take is benchmark, and the content of described active component is 30-50 % by weight, and the content of described adjuvant is 50-70 % by weight.
9. according to the pharmaceutical preparation described in any one in claim 6-8, wherein, described adjuvant is Mel.
10. the pharmaceutical composition described in any one in claim 1-3, the application of the pharmaceutical preparation in claim 4-9 described in any one in the medicine for the preparation for the treatment of gastropathy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410440494.5A CN104189691A (en) | 2014-08-29 | 2014-08-29 | Pharmaceutical composition and pharmaceutical preparation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410440494.5A CN104189691A (en) | 2014-08-29 | 2014-08-29 | Pharmaceutical composition and pharmaceutical preparation and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104189691A true CN104189691A (en) | 2014-12-10 |
Family
ID=52075162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410440494.5A Pending CN104189691A (en) | 2014-08-29 | 2014-08-29 | Pharmaceutical composition and pharmaceutical preparation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104189691A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056196A (en) * | 2015-09-02 | 2015-11-18 | 河南百年康鑫药业有限公司 | Medicine composition for treating peptic ulcer and preparing method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130013A (en) * | 2007-09-05 | 2008-02-27 | 米养素 | Traditional Chinese medicine composition for treating ulcer of stomach and duodenum, and method of preparing the same |
-
2014
- 2014-08-29 CN CN201410440494.5A patent/CN104189691A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130013A (en) * | 2007-09-05 | 2008-02-27 | 米养素 | Traditional Chinese medicine composition for treating ulcer of stomach and duodenum, and method of preparing the same |
Non-Patent Citations (2)
| Title |
|---|
| 李淑英 等: "清热燥湿法治疗萎缩性胃炎188例", 《山西中医》 * |
| 鲍广海 等: "平胃宁蜜丸的临床疗效观察", 《中药通报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056196A (en) * | 2015-09-02 | 2015-11-18 | 河南百年康鑫药业有限公司 | Medicine composition for treating peptic ulcer and preparing method thereof |
| CN105056196B (en) * | 2015-09-02 | 2019-03-08 | 河南百年康鑫药业有限公司 | A kind of pharmaceutical composition and preparation method thereof for treating peptic ulcer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5864252B2 (en) | Medicinal plant extract using smoked product and skin external preparation composition containing the same | |
| CN107303384A (en) | It is a kind of to have medicable Chinese medicine composition and its derivative and product to a variety of symptoms | |
| CN103169903B (en) | Traditional Chinese medicine preparation for treating child bronchitis and preparation method thereof | |
| CN102488850A (en) | Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof | |
| CN105831594A (en) | Delicious tongue-numbing spicy gluten strip and preparation method thereof | |
| CN106039187A (en) | Child Shi-kang tea and preparation method thereof | |
| CN106538786A (en) | A kind of Herba Kalimeridis local flavor Herba Ocimi (Herba Ocimi Pilosi) tea and its production method | |
| KR20160000695A (en) | Herbal-medicine containing dha for recovering fatigue and enhancing memory, and method of manufacturing the same | |
| CN106805235A (en) | A kind of full nutrition formula food suitable for respiratory disease patient | |
| CN104273439A (en) | Noodle capable of tonifying spleen and promoting appetite and preparation method thereof | |
| KR101783549B1 (en) | Health supplement food containing dha for recovering fatigue, and method of manufacturing the same | |
| CN104189691A (en) | Pharmaceutical composition and pharmaceutical preparation and application thereof | |
| CN103444933B (en) | Tea bag for summer health-maintaining noon tea | |
| CN113261600A (en) | Polygonatum sibiricum and coix seed tea and preparation method thereof | |
| CN109646665A (en) | Cortex Eucommiae clearing lung-heat anticancer solid tea and preparation method thereof | |
| CN105535243A (en) | Medicine for treating intractable constipation | |
| CN102512642B (en) | Medicinal composition for treating spleen and stomach diseases and application thereof | |
| CN110478443A (en) | A kind of Chinese medicine treated diabetes and prevent and treat diabetic complication | |
| CN109156778A (en) | A kind of dendrobium candidum haw jelly and preparation method thereof | |
| CN106511547A (en) | Medicine for preventing and treating frog disease in America and preparation method of medicine | |
| CN106620489A (en) | Easy-to-digest cookie and preparation method thereof | |
| CN106434176A (en) | Health wine functional to lower three highs and production method thereof | |
| CN106620632A (en) | Drug capsules for preventing and treating chronic atrophic gastritis | |
| CN106474229A (en) | A kind of protective agents of Rana grylia torticollis disease and preparation method thereof | |
| CN106615500A (en) | Coffee health care jelly |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141210 |
|
| RJ01 | Rejection of invention patent application after publication |