CN102512642B - Medicinal composition for treating spleen and stomach diseases and application thereof - Google Patents
Medicinal composition for treating spleen and stomach diseases and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of treatment of spleen and stomach diseases, and particularly relates to a Chinese medicinal composition for treating spleen and stomach diseases caused by deficiency-cold in spleen and stomach and an application thereof. The medicinal composition is prepared by grinding raw materials including rhizoma curculiginis, epimedium herb, fried atractylodes rhizome, fried bitter orange, cortex cinnamomi, cassia twig, dried orange peel, fingered citron, amomum fruit, costus root, dried ginger and the like, sieving, mixing uniformly for pilling, and drying. The medicinal composition has a strict formula, and is mainly used for treating the spleen and stomach diseases caused by the deficiency-cold in the spleen and stomach. As proved by long-term wide application, the clinical curative effect is remarkable, symptoms are remarkably improved, the reoccurrence rate is low, and toxic and side effects are avoided.
Description
Technical field
The invention belongs to the spleen-stomach disease treatment technology field, specifically, relate to a kind of pharmaceutical composition for the treatment of spleen-stomach deficiency-cold the spleen-stomach disease.
Background technology
Tcm syndrome differentiation and typing is mainly divided into hepatic qi attacking stomach type, spleen-stomach deficiency-cold and type of deficiency of stomach yin etc. by gastropathy, and wherein spleen-stomach deficiency-cold is divided into again simple deficiency and coldness and two hypotypes of the middle empty stagnation of QI.The spleen-stomach disease is clinically very common digestive tract illness, and wherein spleen-stomach deficiency-cold person is in the majority, the showing as of Deficiency and coldness of spleen and stomach: stomach dull pain, like warm pain relieved by pressing, and pain of empty stomach is very, must eat alleviation of pain, general vomiting watery fluid, poor appetite, spiritlessness and weakness, very extremity are not warm, and large loose stool is thin, pale tongue with white fur, and slow pulse is slow or weak.The Chinese patent medicine that is used for the treatment of at present gastropathy is a lot, as Xiangshayangwei capsule, JIANWEI WAN, KUAIWEI PIAN, SANJIU WEITAI electuary, little Rhizoma Pinelliae Mixture and middle reason spleen ball etc., but stagnant, the disperse blood stasis and dredge collateral of being mostly to disappear for regulating the flow of vital energy, clearing away phlegm expel the heat-evil, dispelling cold and activating YANG, the less spleen-stomach deficiency-cold that is used for the treatment of.XIANGSHA LIUJU WAN is comprised of the Radix Aucklandiae, Fructus Amomi, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria Cocos, Radix Glycyrrhizae Preparata etc., the function with replenishing QI to invigorate the spleen stomach function regulating, be applicable to treat the diseases such as the insufficiency of the spleen stagnation of QI, dyspepsia, eructation and poor appetite, distension and fullness in the abdomen, gastral cavilty painful abdominal mass pain, this medicine be take circulation of qi promoting as main, the medicine that is aided with air making-up and spleen enlivening, these medicine flavour of a drug are more, and complex manufacturing is relatively difficult to the overall quality control of medicine.
In doctor trained in Western medicine, gastropathy is divided into acute gastritis, chronic superficial gastritis, chronic atrophic gastritis, gastroduodenal ulcer, gastric cancer etc. conventionally, develop rapidly due to gastroscope technology, binding of pathological is learned biopsy, very easy to the diagnosis of chronic superficial gastritis, however in treatment, still lack reliable means.At present western medicine primary disease be take symptomatic treatment as main, and gastric acid wretched insufficiency person can oral dilute hydrochloric acid, to increase gastric acidity: dyspepsia person can take Pepsin Mixture, polyzyme tablets etc.; Glutted, nauseating, vomiter can answer amine, motilium or cisapride, not husky Billy with stomach; With bile reflux, can destroy gastric mucosal barrier because of long-term bile reflux, cause chronic superficial gastritis, and then develop into chronic atrophic gastritis, can apply medicine for stomach dynamic in the case, prevent bile reflux, thereby reach the object of protection gastric mucosa, motilium or cisapride can resist bile reflux, and promote emptying and emesis; Have a stomachache obvious person with mountain peak eggplant sheet, 654-2 relieving spasm to stop pain; With infected with Helicobacter pylori, also will add antibiotic effects a radical cure with degerming.Sucralfate, Marzulene are gastric mucosa protectants, can reduce the stimulation of external factor to gastric mucosa, are conducive to the recovery of gastric mucosal lesion, various chronic gastritis all available it.Chronic atrophic gastritis adds vitacoenzyme, can improve body immunity, strengthens the activity of detoxication enzyme in human body, anticancer growth and prevent the abnormal metabolism of cell.But more than can only temporarily control the state of an illness, control table disease, can not obtain the effect for the treatment of both the principal and the secondary aspects of a disease at the same time.And long-term taking Western medicine can have side effects and cause yin-Yang imbalance, produce dependency, also may there is dyshormonia, body immunity is declined, and health anti-virus ability is low, and resistance against diseases is poor, make Relapse rate difficulty more finally tend to worsen, lead to complications simultaneously.
Spleen-stomach deficiency-cold the spleen-stomach disease is modal a kind of pattern of syndrome in the numerous types of tcm clinical practice digestive system disease, crowd's sickness rate is high, doctor trained in Western medicine adopts the symptomatic treatments such as acid inhibitor, gastrointestinal prokinetic agent more to the digestive system disease of this kind of pattern of syndrome at present, to this type of gastrointestinal disease without effective treatment means, though exist the similar medicine that is used for the treatment of the spleen-stomach disease all to there is the therapeutical effect to taste on market, but the valuable feature determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of the traditional Chinese medical science will be according to the concrete state of an illness, differential diagnosis of diseases and distinguish disease being used in conjunction with each other, to formulate the therapeutic scheme of a very personalized proper state of an illness.
It is the pharmaceutical preparation that raw material is made that CN 1628730A provides a kind of pharmaceutical composition ，Ta Shiyou Radix Codonopsis extract, Radix et Rhizoma Nardostachyos volatile oil, Rhizoma Zingiberis volatile oil for the treatment of the spleen-stomach disease.The content range that wherein contains the I of tangshenoside in I ，Mei preparation unit of tangshenoside in pharmaceutical preparation is 0.1～3mg.This invention also provides preparation method and the purposes of this pharmaceutical composition.
CN 102068677A relates to a kind of Chinese medicine for the treatment of Deficiency and coldness of spleen and stomach, and it is comprised of the component of following weight material medicine percentage ratio: Radix Codonopsis 20-25%, Rhizoma Atractylodis Macrocephalae 10-15%, Poria 10-15%, Radix Glycyrrhizae 6-10%, Ramulus Cinnamomi 10-15%, Radix Paeoniae Alba 18-22%, Rhizoma Zingiberis 10-15%.
CN 101455833A discloses a kind of compound formulation of Deficiency and coldness of spleen and stomach medicine, adopts Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Zingiberis, Fructus Mume, Fructus Zanthoxyli, after pulverizing, crosses 100 mesh sieves, and mixed at high speed, dries, granulate, and pack, and obtain a kind of Deficiency and coldness of spleen and stomach medicine.
The above several Deficiency and coldness of spleen and stomach medicine has reached certain drug effect in treatment, but pharmacodynamic stability is poor, relatively difficult to the overall quality control of medicine, existing Western medicine side effect is larger, can not treating both the principal and the secondary aspects of a disease at the same time, therefore, be necessary to study a kind of medicine source abundant, clinical efficacy is good, has no side effect, and preparation method is simply treated the medicine of the spleen-stomach disease.
Summary of the invention
The present invention is directed to that the flavour of a drug that the Chinese medicine of existing treatment spleen-stomach deficiency-cold the spleen-stomach disease exists are more, complex manufacturing, drug quality are controlled difficulty and Western medicine is difficult to the easily series of problems such as imbalance for the treatment of both the principal and the secondary aspects of a disease at the same time, physical function, proposed that a kind of prescription is rigorous, clinical efficacy significantly, reduce Chinese medicine composition of the treatment the spleen-stomach disease that recurs, has no side effect and uses thereof.
To achieve these goals, the present invention is achieved through the following technical solutions:
Treat a pharmaceutical composition for the spleen-stomach disease, comprise that the raw material of following weight portion is prepared from: Rhizoma Curculiginis 12～50, Herba Epimedii 16～48, Rhizoma Atractylodis Macrocephalae (parched) 10～35, Fructus Aurantii (parched) 13～30, Cortex Cinnamomi 4～22, Ramulus Cinnamomi 12～35, Pericarpium Citri Reticulatae 9～28, Fructus Citri Sarcodactylis 7～23, Fructus Amomi 2～17, the Radix Aucklandiae 2～18, Rhizoma Zingiberis 1～24.
Rhizoma Curculiginis is perennial herb, and rhizome extends, and length can reach 30 centimetres, cylindric, meat, crust brown; Root is sturdy, meat, and the aerial stem of plant is not obvious.There is the effect of reinforcing the kidney and supporting YANG, benefiting essence-blood, bone and muscle strengthening and promoting the circulation of blood detumescence, be mainly used in the diseases such as insufficiency of kidney-YANG, impotence and seminal emission, chronic consumptive disease internal injury and bones and muscles pain.Its main component contains tannin 4%, fat 1% and resin, starch etc.Also containing lycorine, yuccagenin, cupreol.From the water soluble part of rhizome, separation obtains curculigoside B, curculigineB and C and orcinol glucoside.The effects such as modern pharmacology activity research shows that Rhizoma Curculiginis has immunity, the antioxidation of adjusting, protects the liver, hyperglycemia, kidney invigorating and YANG supporting and osteoporosis, antiinflammatory and adaptation former state.
Herba Epimedii also claims Herba Epimedii, and Berberidaceae plant lobus cardiacus, has very high medical value.Herba Epimedii mainly contains icariine etc., and Herba Epimedii extracting solution has the effect of androgen sample, can promote gonepoiesis, blood sugar lowering; Be improved hypophysis--the effect of interrenal system function, and can form by enhancing antibody.Taste is returned through acrid, sweet, warm, returns liver, kidney channel, cures mainly function: kidney-replenishing, and bone and muscle strengthening, wind-damp dispelling, for impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
The Rhizoma Atractylodis Macrocephalae is perennial herb, and the nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration.Rhizoma Atractylodis Macrocephalae (parched) is that processed with honey wheat bran is sprinkled in heat pot, adds Rhizoma Atractylodis Macrocephalae sheet when smoldering, and fries to coke yellow, effusion burnt odor gas, takes out, and sieve removes processed with honey wheat bran.Rhizoma Atractylodis Macrocephalae (parched) dampness, QI invigorating, spleen invigorating, stomach invigorating, Hang Shui.Be mainly used in the spleen-stomach disease, deficiency of spleen-QI, retention of dampness in middle-JIAO.
Fructus Aurantii is irregular arcuation bar shaped thin slice, and tangent plane outer peel sepia is to brown, and mesocarp yellow-white is to yellowish-brown, and nearly outer rim has 1～2 row point-like grease chamber, and inner side has a small amount of puce pulp.Fructus Aurantii (parched) is irregular arcuation bar shaped thin slice, and color is darker, and what have has a focal spot.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.The raw Fructus Aurantii property of medicine is more violent, and after frying, the property of medicine relaxes, also much smaller to the stimulation of stomach.
Cortex Cinnamomi is containing volatile oil approximately 1%, in containing phellandrene, eugenol, methyleugenol.Leaf is containing volatile oil approximately 1%, in containing safrole approximately 60%, eugenol approximately 3%, 1,8-presses foline etc.Function is warming the spleen stomach, warm Liver and kidney, cold-dispelling pain-relieving, dissipating blood stasis for subsidence of swelling; Main coldness and pain in the epigastrium, vomiting is had loose bowels, and the acid of waist knee joint is cold, colic of cold type stomachache, arthralgia due to cold-dampnes, the stagnant dysmenorrhea of the stasis of blood, dysentery, hemorrhoidal hamorrhage, treating swelling and pain by traumatic injury.
Ramulus Cinnamomi is the dry twig of Lauraceae aiphyllium plant Cortex Cinnamomi.For similar round, oval-shaped or difform section.Skin zone's rufous, surface is visible point-like hole skin or vertical crest line sometimes, woody part yellow-white or light yellowish brown, marrow similar round or be slightly square.Main product in Guangxi, the ground such as Guangdong and Yunnan.Spring, summer are cut twig, dry or dry in the shade, and thinly slice or segment use.Function is diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange and variety thereof.Pluck mature fruit, strip peel, dry or cold drying.For diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, for lung qi, gather around the diseases such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen.The compatibility application such as normal and the Radix Aucklandiae, Fructus Aurantii, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough, for insufficiency of the spleen diet minimizing, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea.
Fructus Citri Sarcodactylis is containing volatile oil, Coumarins compound, and main component has bergapten, Limettin, Hesperidin, hottentot tea glycosides (diosmin) etc.The root of Fructus Citri Sarcodactylis, stem, leaf, flower, fruit all can be used as medicine, pungent, bitter, sweet, warm, nontoxic; Enter liver, spleen, stomach three warps, have activating QI to eliminate phlegm, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating, the more kinds of medicinal functions of stomach function regulating.Old people's tracheitis, asthma are had to obvious mitigation; Vexed to common people's dyspepsia, breast abdominal distention, there is more significant curative effect.Pinus densiflora gold bergamot can be made into several kinds of Chinese medicinal materials, and clothes have the effect of health-care for a long time.Liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite vomiting.
The traditional Chinese medical science thinks, Fructus Amomi Main Function is in stomach, kidney and the spleen of human body, can circulation of qi promoting seasoning, and stomach function regulating is amusing.Fructus Amomi often coordinates with Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae etc., the diseases such as treatment fullness in the epigastrium and chest, abdominal distention and little diet.Containing volatile oil, in oil, containing borneol acetate, Camphora, lauro lene, limonene, nopinene, nerolidol and australene, camphene, eucalyptol, linalool, α-capaene, 3,8-dimethyl-5-(.alpha.-hydroxyisopropyl)-.DELTA.9-octahydroazulene etc., separately contain flavones ingredient.
The Radix Aucklandiae is returned spleen; Stomach; Liver; Lung meridian, containing volatile oil, in oil, contain myrcene, p-cymene, linalool, beta-elemene, Flos Caryophylli alkene, humulene, cedrene, alpha, beta-lonone, cedrol, α-costol, 1,8,11,14 positive 17 tetraenes and constuslactone, dihydrocostulactone, dehydrocostuslactone, costunolide, dihydro costunolide, 12-melonia costunolide and 12-melonia dehydrocostuslactone.Another containing α-costic acid and 24 seed amino acids. cure mainly born of the same parents and coerce distension foot, abdominal distention, tells and has loose bowels, heavy after dysentery.
Rhizoma Zingiberis acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention, cures mainly coldness and pain in the epigastrium, and vomiting, has loose bowels, and YANG-depletion is fainted contrary, and cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes.This product is hot dry strong, and master enters taste and is longer than warming spleen and stomach for dispelling cold, strong activating the spleen sun.Control gastrofrigid vomiting, coldness and pain in the epigastrium, often joins Rhizoma Alpiniae Officinarum and uses.Control Deficiency and coldness of spleen and stomach, coldness and pain in the epigastrium, vomiting is had loose bowels, and many and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae are equal to use.
Above raw material, after optimum organization of the present invention, is made the Chinese medicine preparation for the treatment of the spleen-stomach disease, not only can bring into play separately original effect, more can further strengthen its curative effect, and treatment spleen-stomach deficiency-cold the spleen-stomach disease is had to the effect that is better than existing medicine.
As optimal technical scheme, treat a pharmaceutical composition for the spleen-stomach disease, comprise that the raw material of following weight portion is prepared from: Rhizoma Curculiginis 18～42, Herba Epimedii 22～40, Rhizoma Atractylodis Macrocephalae (parched) 14～33, Fructus Aurantii (parched) 17～27, Cortex Cinnamomi 6～17, Ramulus Cinnamomi 16～30, Pericarpium Citri Reticulatae 14～23, Fructus Citri Sarcodactylis 9～16, Fructus Amomi 4～13, the Radix Aucklandiae 3～15, Rhizoma Zingiberis 4～14.
As optimal technical scheme, treat a pharmaceutical composition for the spleen-stomach disease, comprise that the raw material of following weight portion is prepared from: Rhizoma Curculiginis 25～33, Herba Epimedii 27～31, Rhizoma Atractylodis Macrocephalae (parched) 18～27, Fructus Aurantii (parched) 18～23, Cortex Cinnamomi 8～12, Ramulus Cinnamomi 19～26, Pericarpium Citri Reticulatae 16～23, Fructus Citri Sarcodactylis 11～14, Fructus Amomi 5～10, the Radix Aucklandiae 6～13, Rhizoma Zingiberis 5～9.
As optimal technical scheme, treat a pharmaceutical composition for the spleen-stomach disease, comprise that the raw material of following weight portion is prepared from: Rhizoma Curculiginis 30, Herba Epimedii 30, Rhizoma Atractylodis Macrocephalae (parched) 20, Fructus Aurantii (parched) 20, Cortex Cinnamomi 10, Ramulus Cinnamomi 20, Pericarpium Citri Reticulatae 20, Fructus Citri Sarcodactylis 12, Fructus Amomi 6, the Radix Aucklandiae 10, Rhizoma Zingiberis 6.
" comprising " of the present invention, mean it except described component, can also comprise other components, these other components give described pharmaceutical composition different characteristics.In addition, " comprising " of the present invention, can also replace with enclosed " being " or " by ... form ".
Chinese medicine preparation refers to that any medicine, for all making the form that is suitable for medical treatment or prophylactic applications before clinical, is called dosage form, such as tablet, injection, aerosol, pill, powder, unguentum etc.Dosage form is collective noun, generally refers to the classification of preparation, any one the concrete kind in dosage form, and such as the YUANHU ZHITONG PIAN in tablet, the ZHICHUANLING ZHUSHEYE in injection, the pill of costus and amomum with six noble ingredients in pill etc. is called preparation.Wherein, pill refers to that medical material fine powder or medicinal substances extract add the spherical or class ball sheet shape preparation that suitable bonding adjuvant is made.The watered pill also claims water pill, is to be the pellet shapes pill that bonding (moistening) agent is made by cold boiled water, medicine juice or other liquid for fine drug powder.The watered pill is to develop and form on the basis of decoction.Beginning juice of decocting of a part of medicine in writing out a prescription makes decoction pill with the fine powder of another part medicine to drip into the method for ball, then develops gradually, take various water-soluble liquids as binding agent, by general method for making, all or part of fine drug powder in side is made to piller.General pill grain, volume is little, and surface compact is smooth, has both been convenient to swallow, and is difficult for again the moisture absorption, is conducive to keeping and stores.Because its binding agent is water miscible, take rear easy disintegrating and absorb, effective very fast.Pharmaceutical composition of the present invention is pill, preferably makes water pill.Other form of Chinese drug that those skilled in the art can be known all can be used for the present invention, can rule of thumb select with practical situation, there is no particular restriction.The categories of excipients of the watered pill is more, and they are mainly moistening drug powders, brings into play its cohesive, strengthens outside the viscosity of fine drug powder the dissolubility that can increase some active ingredient in principal agent having; What have itself has certain curative effect.Water is most widely used in general ball, topmost excipient.Though water itself is inviscid, the phlegmatic temperament in energy moistening dissolved substance, sugar, starch, colloid etc., produce viscosity after moistening, can the general ball of making.In order to guarantee the quality of finished product, reduce the pollution of microorganism, should select and newly boil water or the distilled water letting cool.The medicine that has Cardiac glycosides in prescription, as Folium Digitalis Purpureae etc., should not use water as wetting agent, because water can make the enzyme in former medicated powder decompose gradually cardiotonic glycoside.In prescription, contain and draw moist or soluble component and poison, drastic etc., should first dissolve or mix in a small amount of water, in order to dispersion.Mix general ball with other drug again, on all clinical treatments to excipient without specific (special) requirements, medicine is met the water person of never degenerating, all available water pill, general Cheng Houying is dry immediately.Other binding agents also can be selected according to practical situation, all can be used for implementing the present invention.
The above-described pharmaceutical composition of the present invention is mainly used in treating spleen-stomach deficiency-cold the spleen-stomach disease.Deficiency and coldness of spleen and stomach, same deficiency of spleen-YANG, due to drinking and eating irregularly, eating cold and uncooked food excessively, overstrain or prolonged illness or melancholy impairing the spleen etc.Disease see indigestion and loss of appetite abdominal distention, abdominal pain and like that warm pain relieved by pressing, tastelessness and no thirst, extremity are not warm, loose stool or extremity edema, aversion to cold and preference for warmth, clear urine in large amounts or unfavorable, women's clear and thin leucorrhea be and many, light red tongue is fat tender, tongue fur is white and moist, deep-slow pulse etc.Symptoms, for often causing pain because weather turns cold, feels the cold product of cold food, with the cold and cool sense of stomach, obtains warm symptom and alleviates during pain.Stomachache is indistinctly, endlessly continuous, and cold type of pain is uncomfortable, likes warm pain relieved by pressing, and pain of empty stomach very, obtains food slow, tired or eat cold or suffer from cold after pain outbreak or increase the weight of, general vomiting watery fluid, lack of appetite, spiritlessness and weakness, hands and feet being not warm, large loose stool is thin, pale tongue with white fur, deficient and weak pulse.The Etiological of Deficiency and coldness of spleen and stomach is that dietary habit is bad as eating and drinking without temperance system, often eat cold drink or ice-cold food causes.Add rhythm of life fast, stress is large, more easily causes gastropathy, so need form good dietary habit.
Compare with prior art scheme, the present invention has following beneficial effect:
Product of the present invention uses through the clinical practice over more than 10 years, and prescription is rigorous, avoids using the high strong product of warm-dryness syndrome, cures mainly spleen-stomach deficiency-cold taste patient, clinical efficacy is remarkable, obviously improves symptom, cure diseases, reduce recurrence, have no side effect, firmly get Building patient trust and welcome.The medicine pill that the present invention makes is through a large amount of clinical uses, and while using 20 days left and right, 85% patient cures substantially, various transference cures, and it is normal that physical function recovers.
Below the present invention is described in more detail.But following example is only simple and easy example of the present invention, does not represent or limit the scope of the present invention, and interest field of the present invention is as the criterion with claims.
The specific embodiment
For the present invention is described better, be convenient to understand technical scheme of the present invention, typical but non-limiting embodiment of the present invention is as follows:
Embodiment 1
Get Rhizoma Curculiginis 30g, Herba Epimedii 30g, Rhizoma Atractylodis Macrocephalae (parched) 20g, Fructus Aurantii (parched) 20g, Cortex Cinnamomi 10g, Ramulus Cinnamomi 20g, Pericarpium Citri Reticulatae 20g, Fructus Citri Sarcodactylis 12g, Fructus Amomi 6g, Radix Aucklandiae 10g, Rhizoma Zingiberis 6g, respectively through grinding 120 mesh sieves, obtain fine powder, newly to boil the water or the distilled water that let cool, do binding agent, each medicine mixes general ball, after general one-tenth, is dried and makes finished product immediately.
Embodiment 2
Get Rhizoma Curculiginis 12g, Herba Epimedii 48g, Rhizoma Atractylodis Macrocephalae (parched) 35g, Fructus Aurantii (parched) 13g, Cortex Cinnamomi 4g, Ramulus Cinnamomi 35g, Pericarpium Citri Reticulatae 9g, Fructus Citri Sarcodactylis 23g, Fructus Amomi 17g, Radix Aucklandiae 2g, Rhizoma Zingiberis 24g, respectively through grinding 100 mesh sieves, obtain fine powder, newly to boil the water or the distilled water that let cool, do binding agent, each medicine mixes general ball, after general one-tenth, is dried and makes finished product immediately.
Embodiment 3
Get Rhizoma Curculiginis 50g, Herba Epimedii 22g, Rhizoma Atractylodis Macrocephalae (parched) 10g, Fructus Aurantii (parched) 17g, Cortex Cinnamomi 17g, Ramulus Cinnamomi 12g, Pericarpium Citri Reticulatae 28g, Fructus Citri Sarcodactylis 7g, Fructus Amomi 4g, Radix Aucklandiae 15g, Rhizoma Zingiberis 14g, respectively through grinding 120 mesh sieves, obtain fine powder, newly to boil the water or the distilled water that let cool, do binding agent, each medicine mixes general ball, after general one-tenth, is dried and makes finished product immediately.
Embodiment 4
Get Rhizoma Curculiginis 18g, Herba Epimedii 16g, Rhizoma Atractylodis Macrocephalae (parched) 33g, Fructus Aurantii (parched) 27g, Cortex Cinnamomi 22g, Ramulus Cinnamomi 16g, Pericarpium Citri Reticulatae 14g, Fructus Citri Sarcodactylis 9g, Fructus Amomi 2g, Radix Aucklandiae 18g, Rhizoma Zingiberis 1g, respectively through grinding 120 mesh sieves, obtain fine powder, newly to boil the water or the distilled water that let cool, do binding agent, each medicine mixes general ball, after general one-tenth, is dried and makes finished product immediately.
Embodiment 5
Get Rhizoma Curculiginis 42g, Herba Epimedii 40g, Rhizoma Atractylodis Macrocephalae (parched) 14g, Fructus Aurantii (parched) 30g, Cortex Cinnamomi 6g, Ramulus Cinnamomi 30g, Pericarpium Citri Reticulatae 23g, Fructus Citri Sarcodactylis 16g, Fructus Amomi 13g, Radix Aucklandiae 3g, Rhizoma Zingiberis 4g, respectively through grinding 120 mesh sieves, obtain fine powder, newly to boil the water or the distilled water that let cool, do binding agent, each medicine mixes general ball, after general one-tenth, is dried and makes finished product immediately.
Embodiment 6
Get Rhizoma Curculiginis 24g, Herba Epimedii 30g, Rhizoma Atractylodis Macrocephalae (parched) 21g, Fructus Aurantii (parched) 27g, Cortex Cinnamomi 10g, Ramulus Cinnamomi 26g, Pericarpium Citri Reticulatae 20g, Fructus Citri Sarcodactylis 16g, Fructus Amomi 11g, Radix Aucklandiae 8g, Rhizoma Zingiberis 13g, respectively through grinding 100 mesh sieves, obtain fine powder, newly to boil the water or the distilled water that let cool, do binding agent, each medicine mixes general ball, after general one-tenth, is dried and makes finished product immediately.
Embodiment 7
Get Rhizoma Curculiginis 25g, Herba Epimedii 27g, Rhizoma Atractylodis Macrocephalae (parched) 27g, Fructus Aurantii (parched) 18g, Cortex Cinnamomi 8g, Ramulus Cinnamomi 26g, Pericarpium Citri Reticulatae 16g, Fructus Citri Sarcodactylis 11g, Fructus Amomi 10g, Radix Aucklandiae 6g, Rhizoma Zingiberis 5g, respectively through grinding 120 mesh sieves, obtain fine powder, newly to boil the water or the distilled water that let cool, do binding agent, each medicine mixes general ball, after general one-tenth, is dried and makes finished product immediately.
Embodiment 8
Get Rhizoma Curculiginis 33g, Herba Epimedii 31g, Rhizoma Atractylodis Macrocephalae (parched) 18g, Fructus Aurantii (parched) 23g, Cortex Cinnamomi 12g, Ramulus Cinnamomi 19g, Pericarpium Citri Reticulatae 23g, Fructus Citri Sarcodactylis 14g, Fructus Amomi 5g, Radix Aucklandiae 13g, Rhizoma Zingiberis 9g, respectively through grinding 100 mesh sieves, obtain fine powder, newly to boil the water or the distilled water that let cool, do binding agent, each medicine mixes general ball, after general one-tenth, is dried and makes finished product immediately.
Applicant's statement, person of ordinary skill in the field is on the basis of above-described embodiment, by the concrete content point value of above-described embodiment component, combined with the technical scheme of summary of the invention part, thereby the new numerical range producing, also be one of record scope of the present invention, the application, for making description simple and clear, is no longer enumerated these numerical rangies.
Product warming middle-JIAO and strengthening the spleen of the present invention, for spleen-stomach deficiency-cold gastralgia, aversion to cold and cold limbs, belch abdominal distention, anorexia, the disease such as limbs are weak, diarrhea with loose stool.
For the therapeutical effect of test Chinese medicine of the present invention to spleen-stomach deficiency-cold the spleen-stomach disease, select 550 routine patients to carry out clinical observation, select spleen-stomach deficiency-cold the spleen-stomach disease patient 530 examples that medical history, the state of an illness, age and former Therapeutic Method are suitable as a control group simultaneously.The medicine pill that test group adopts the embodiment of the present invention 1 to make carries out the treatment of the spleen-stomach disease, and matched group is treated according to a conventional method.
Therapeutic Method: the medicine pill that embodiment 1 is made, the each 3g of test group patient (effective dose), take orally every day for three times, and clinical test results is as shown in the table.
As can be seen from the above table, use after medicine pill couple of days of the present invention, 95% patient has stomach pain to weaken, and appetite takes a turn for the better, and abdominal distention weakens phenomenon, to human body without any injury; After 8 days, 90% the various symptoms of patient obviously alleviate; Use after 20 days, the various symptoms of patient's the spleen-stomach disease of 85% disappear substantially, and all the other patients recover, and estimate that after 5～10 days, symptom can all disappear, and recover normal.And still have no while using the matched group to 20 day of traditional therapy, be clearly better, estimate also to need long period treatment, slowly recover.
Medicine pill of the present invention is through being widely used for a long time, and clinical cure rate reaches 75%, and effective percentage reaches 90%.
Applicant's statement, the present invention illustrates preparation and the use of pharmaceutical composition of the present invention by above-described embodiment, but the present invention is not limited to above-mentioned preparation method, does not mean that the present invention must rely on above-mentioned preparation method and could implement.Person of ordinary skill in the field should understand, any improvement in the present invention, to the selection of the interpolation of the equivalence replacement of the selected raw material of the present invention and auxiliary element, concrete mode etc., within all dropping on protection scope of the present invention and open scope.
Claims (8)
1. treat a pharmaceutical composition for the spleen-stomach disease, by the raw material of following weight portion, be prepared from: Rhizoma Curculiginis 12～50, Herba Epimedii 16～48, Rhizoma Atractylodis Macrocephalae (parched) 10～35, Fructus Aurantii (parched) 13～30, Cortex Cinnamomi 4～22, Ramulus Cinnamomi 12～35, Pericarpium Citri Reticulatae 9～28, Fructus Citri Sarcodactylis 7～23, Fructus Amomi 2～17, the Radix Aucklandiae 2～18, Rhizoma Zingiberis 1～24.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, by the raw material of following weight portion, be prepared from: Rhizoma Curculiginis 18～42, Herba Epimedii 22～40, Rhizoma Atractylodis Macrocephalae (parched) 14～33, Fructus Aurantii (parched) 17～27, Cortex Cinnamomi 6～17, Ramulus Cinnamomi 16～30, Pericarpium Citri Reticulatae 14～23, Fructus Citri Sarcodactylis 9～16, Fructus Amomi 4～13, the Radix Aucklandiae 3～15, Rhizoma Zingiberis 4～14.
3. pharmaceutical composition as claimed in claim 1 or 2, it is characterized in that, by the raw material of following weight portion, be prepared from: Rhizoma Curculiginis 25～33, Herba Epimedii 27～31, Rhizoma Atractylodis Macrocephalae (parched) 18～27, Fructus Aurantii (parched) 18～23, Cortex Cinnamomi 8～12, Ramulus Cinnamomi 19～26, Pericarpium Citri Reticulatae 16～23, Fructus Citri Sarcodactylis 11～14, Fructus Amomi 5～10, the Radix Aucklandiae 6～13, Rhizoma Zingiberis 5～9.
4. pharmaceutical composition as claimed in claim 1, it is characterized in that, by the raw material of following weight portion, be prepared from: Rhizoma Curculiginis 30, Herba Epimedii 30, Rhizoma Atractylodis Macrocephalae (parched) 20, Fructus Aurantii (parched) 20, Cortex Cinnamomi 10, Ramulus Cinnamomi 20, Pericarpium Citri Reticulatae 20, Fructus Citri Sarcodactylis 12, Fructus Amomi 6, the Radix Aucklandiae 10, Rhizoma Zingiberis 6.
5. pharmaceutical composition as claimed in claim 1, is characterized in that, described pharmaceutical composition is pill.
6. pharmaceutical composition as claimed in claim 5, is characterized in that, described pharmaceutical composition is made water pill.
7. pharmaceutical composition as claimed in claim 6, is characterized in that, described water pill selects water to do binding agent.
8. a pharmaceutical composition as claimed in claim 1 is treated the application in spleen-stomach deficiency-cold the spleen-stomach disease medicine in preparation.
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| CN201110419628.1A CN102512642B (en) | 2011-12-15 | 2011-12-15 | Medicinal composition for treating spleen and stomach diseases and application thereof |
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| CN201110419628.1A CN102512642B (en) | 2011-12-15 | 2011-12-15 | Medicinal composition for treating spleen and stomach diseases and application thereof |
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| CN102784374B (en) * | 2012-08-03 | 2014-04-16 | 林红丽 | Traditional Chinese medicine composition for treating stomachache cold gastrodynia |
| CN107583005A (en) * | 2017-06-01 | 2018-01-16 | 合肥远志医药科技开发有限公司 | A kind of formula and its extraction process for invigorating the spleen middle benefit gas |
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| CN1110589A (en) * | 1994-10-21 | 1995-10-25 | 孟灵源 | Pill for treating splenico or gastric vital energy deficiency type chronic superficial, atrophic gastritis |
| CN101766803B (en) * | 2010-04-09 | 2011-04-27 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating epigastric pain and preparation method thereof |
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