CN100509003C - Medicament of treating psoriasis - Google Patents

Abstract

The present invention relates to a medicine for effectively curing psoriasis. Its raw material composition includes (by weight portion) 40-50 portions of realgar, 12-18 portions of hematite, 8-12 portions of calcined oyster shell, 12-18 portions of sulfur, 3-7 portions of krait/agkistrodon, 3-5 portions of scorpion, 3-7 portions of indigo and 0.5-1.5 portions of borneol. Said invention also provides its preparation method and concrete steps.

Description

A kind of antipsoriatics thing

Technical field

The invention belongs to a kind of Chinese medicine.

Background technology

" psoriasis " claims psoriasis again, is a kind of common chronic inflammatory disease dermatoses, has the characteristics of intractable and recurrent, and be obviously seasonal.

" psoriasis " cause of disease complexity, each airs his own views for the medical circle Chinese and Western medicine.The traditional Chinese medical science think many by battalion defend become estranged, the ailment said due to cold or exposure invasion; Temperament and interest internal injury, stagnation of QI-blood; Intemperance of taking food, taste are become estranged; Blood-deficiency and wind-dry, failure of skin and muscle to be nourished; Can not lead off outward, interior can not profit leading, QI and blood does not freely hinder in the flesh table gives birth to.Doctor trained in Western medicine thinks relevant with heredity, infective virus or factors such as antibacterial, immunity, metabolism and endocrine " psoriasis ".Traditional Therapeutic Method is many based on medicine for external use.

Antipsoriatics article kind is various, and cure rate is lower, and side effect is bigger.The aminopterin of using the sixties once had the death cases of causing, used ethyliminum and bimolane the seventies and leukemogenesis and other malignant tumor.Also have methotrexate application for a long time can cause liver cirrhosis.The new drug ciclosporin of using can cause the kidney toxication recently, and retinoic acid can cause monster or the like, is to attend to one thing and lose sight of another.

And some anxious patients that cure the disease are as after having used the corticosteroids medicine, though erythra can temporarily disappear very fast recurrence again, and the oncoming force is more violent, cause easily that sb.'s illness took a turn for the worse, make patient not only waste wealth, also health caused new injury, reduced autoimmunity.

Also have a lot of Chinese herbal and crude drugs preparations Main Ingredients and Appearances with Cortex Moutan, Radix Rubiae, Flos Lonicerae, favus skin, Spina Gleditsiae, the Fructus Kochiae, Radix Paeoniae Rubra, Poria etc., pharmacology with clear medicine detoxify, dandruff-removing itching-relieve is basis, lacks the effect of hard masses softening and resolving, detoxicating and killing parasites.Other has various medicine for external use or ointment to smear agent, though external can be played sterilizing and itch-relieving, lubricated skin, the dry and cracked effect of control, does not have basic therapeutical effect.

Summary of the invention

The invention provides a kind of antipsoriatics thing, side effect, curative effect instability, the bad problem of medicine for external use effect arranged with what solve that present antipsoriatics thing exists.

Follow the traditional theory of the traditional Chinese medical science, should be with strengthening the body resistance, blood-cleaning detoxifying, expelling wind and removing dampness, killing parasites for relieving itching are principle.Based on oral medicine, take stopgap measures and effect a permanent cure earlier.Take the mode for the treatment of the poisonous disease with poisonous drugs, improve body immunity, strengthen microcirculation.

Being monarch drug with Realgar, sulfur in the side, borrowing detoxifcation parasite killing, dampness removing to stop itchin, is main; With Agkistrodon, Scorpio is ministerial drug, and removing blood stasis, dispersing pathogen accumulation dredge the meridian passage are auxilliary; With Concha Ostreae (calcined), Haematitum is assistant, the deficiency of hard masses softening and resolving, suppressing the hyperactive liver and subsiding YANG, cooling blood for hemostasis, blending negative and positive, QI and blood; With Indigo Naturalis, Borneolum Syntheticum for make, blood cooling and ecchymoses removing, heat-clearing and toxic substances removing, bring into play complementary separately effect.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components is for all having better curative effect in the following weight parts scope:

40～50 parts of Realgars, 12～18 parts of Haematitums, 8～12 parts of Concha Ostreae (calcined)s, 12～18 parts in sulfur, 3～7 parts of Agkistrodons, 3～5 parts of Scorpio, 3～7 parts of Indigo Naturaliss, 0.5～1.5 part of Borneolum Syntheticum.

Be preferably:

45 parts of Realgars, 15 parts of Haematitums, 10 parts of Concha Ostreae (calcined)s, 15 parts in sulfur, 5 parts of Agkistrodons, 4 parts of Scorpio, 5 parts of Indigo Naturaliss, 1 part of Borneolum Syntheticum.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.Preferably the preparation method of medicine activity component of the present invention is as follows:

Each medicine pulverize separately is become 80～100 purpose smalls, and should whole medicament mixed even.

The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into any peroral dosage form commonly used as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as granule, pill, powder, tablet, capsule, oral liquid etc.

The property of medicine of Chinese prescription of the present invention for flat, temperature, cool, be slightly cold, the salty and bitter and cold cushion of taking into account, attend to one thing and lose sight of another avoiding, can avoid causing the damage internal organs because of the treatment dermatosis, make the more comprehensive and treating both the principal and secondary aspects of a disease of drug effect, demonstrate fully the organic conception and the advantage of the traditional Chinese medical science, remove the misery of human body and psychology for the patient.

Medication 1～3 month was a course of treatment, and the affected part of original psoriasic position of patient and discharge will disappear 90～95%, and 1～4 course of treatment of general therapeutic, curative effect is better.Every medicine contains crude drug amount 0.08 gram, two of oral every days, takes at twice.

The specific embodiment

The preparation of embodiment 1 pill of the present invention.

Realgar 450 grams, Haematitum 150 grams, Concha Ostreae (calcined) 100 grams, sulfur 150 grams, Agkistrodon 50 grams, Scorpio 40 grams, Indigo Naturalis 50 grams, Borneolum Syntheticum 10 grams.

Each medicine pulverize separately is become 80～100 purpose smalls, and should whole medicament mixed even, add medicinal dextrin and make pill, make 12500 altogether, every contains crude drug amount 0.08 gram.

The preparation of embodiment 2 tablets of the present invention

Realgar 400 grams, Haematitum 120 grams, Concha Ostreae (calcined) 80 grams, sulfur 120 grams, Agkistrodon 30 grams, Scorpio 30 grams, Indigo Naturalis 30 grams, Borneolum Syntheticum 5 grams.

Each medicine pulverize separately is become 80～100 purpose smalls, and should whole medicament mixed even, add the conventional adjuvant of preparation tablet, make tablet.

The preparation of embodiment 3 capsules of the present invention

Realgar 500 grams, Haematitum 180 grams, Concha Ostreae (calcined) 120 grams, sulfur 180 grams, Agkistrodon 70 grams, Scorpio 50 grams, Indigo Naturalis 70 grams, Borneolum Syntheticum 15 grams.

Each medicine pulverize separately is become 80～100 purpose smalls, and should whole medicament mixed even, incapsulate.

Experimental example: the visual report of the clinical use of the present invention.

One, natural situation

Male's 60 examples, women's 40 examples

Age: 16～25 years old 20 example, 26～35 years old 20 example, 36～45 years old 30 example, 46～55 years old 15 example, 56～65 years old 15 example.

Medical history: 3～5 years 20 examples, 6～15 years 50 examples, 30 examples more than 16～20 years, the affected part position: most of at head, the extremities joint place, back, waist, 15 years above person's abdominal paries of medical history occur, and area is bigger.

Two, the course of treatment and administrated method

3 months is a course of treatment, oral medicine, and every day is early, evening, respectively once each one, half an hour, plain boiled water took after meal, and every contains crude drug amount 0.08 gram.

Three, curative effect determinate standard

1, produce effects: medication silver bits can occur and increase and very itch after 3～5 days, 15～20 day laundering period, white scales begins to eliminate after 40 days, the skin affected part color that reddens.

2, effective: one the course of treatment interval, former affected part can be eliminated more than 90～95% with medication eliminating position, remaining position is former ground.

3, cure: because of psoriasis is periodically obvious, answer the medication after treatment, virus is got rid of once more, through 3～4 courses of treatment, recovering skin normally has state, generally no longer recurrence.

4, invalid: the silver bits disappear and are lower than 50%.It is old that reason mostly is, and other disease that occurs together is used atypical medicine, and suffer from the dermatosis time limit than the elder.

100 routine psoriatic's therapeutic outcome statistical tables

	Age	The example number	Medical history (year)	First course of treatment of produce effects	Effective second course of treatment	Cured for the 3rd course of treatment	Invalid the 4th course of treatment
								Psoriasis	16～25	20	3～5	20	20	20
	26～35	20	6～15	20	20	20
									36～45	30	6～15	30	30	29	1
	46～55	15	16～20	15	15	13	3
									56～65	15	More than 20 years	15	15	8	7
		100		100％	100％	90％	10％

Medication 3 months was a course of treatment, obvious effective rate 100%; Two courses of treatment of medication, the affected part of original psoriasic position of patient and discharge will disappear 90～95%, and 1～4 course of treatment of general therapeutic, curative effect is better.It is old that cause of invalidity mostly is, and other disease that occurs together is used atypical medicine, and suffer from the dermatosis time limit than the elder.

Claims (2)

1, a kind of antipsoriatics thing is characterized in that in weight portion, makes raw materials of effective components and consists of:

40～50 parts of Realgars, 12～18 parts of Haematitums, 8～12 parts of Concha Ostreae (calcined)s, 12～18 parts in sulfur, 3～7 parts of Agkistrodons, 3～5 parts of Scorpio, 3～7 parts of Indigo Naturaliss, 0.5～1.5 part of Borneolum Syntheticum.

2, antipsoriatics thing according to claim 1 is characterized in that in weight portion, makes raw materials of effective components and consists of:

45 parts of Realgars, 15 parts of Haematitums, 10 parts of Concha Ostreae (calcined)s, 15 parts in sulfur, 5 parts of Agkistrodons, 4 parts of Scorpio, 5 parts of Indigo Naturaliss, 1 part of Borneolum Syntheticum.