CN108030847A - A kind of pharmaceutical composition for treating constipation and its application - Google Patents
A kind of pharmaceutical composition for treating constipation and its application Download PDFInfo
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Abstract
Pharmaceutical composition and its application the invention discloses a kind of external curing constipation, described pharmaceutical composition are made of the raw material of parts by weight as described below：20 30 parts of apricot kernel oil, 15 25 parts of honey, 20 30 parts of fructus cannabis oil, 7 13 parts of siritch, 7 13 parts of betel oil, 7 13 parts of longan gravy.The invention has the advantages that：1st, the component of pharmaceutical composition of the present invention, proportioning are by screening, and mutually coordinated performance greatest treatment efficacy between each medicine, lasting medicine, has no toxic side effect, and is worthy of popularization.2nd, pharmaceutical composition of the invention has the effect of good for constipation, can significantly improve constipation patient belly turgor, constipation symptom, high efficiency.3rd, enema of the invention have have no toxic side effect, preparation method it is simple, with it is simple and easy to do the advantages that, suitable for long-time service, be a kind of medicine of safely and effectively treatment constipation, have a good application prospect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for treating constipation and its application, and in particular to a kind of bowel lavage for treating constipation
Agent.
Background technology
Constipation refers to the reduction of defecating number, while difficult defecation, excrement are dry and hard.Constipation can be divided into Treatment of Outlet Obstruction Type Constipation
And Colonic Slow Transit Constipation.Wherein the former is more common in the elderly, more because pelvic diaphragm muscle relaxes, powerless that excrement is discharged.
Western medicine constipation is divided into three classes according to the mechanism of relieving constipation by purgation：The first kind is irritant laxative, this kind of cathartic and its internal generation
Thanking to product directly stimulates intestinal wall, strengthens enterocinesia, so that promote excrement to discharge, but long-time service can cause enteron aisle irritability to drop
It is low, so should not commonly use.Second class is dilution property cathartic.This kind of cathartic can prevent intestinal absorption moisture, increase enteral volume,
It is difficult to absorb after they are oral at the same time, very high osmotic pressure can be formed in the intestine, increases moisture and chyme capacity, due to capacity
Greatly, enteron aisle is expanded, and mechanically stimulates enteron aisle, cause enterocinesia enhancing and defecation.Three classes are emollient cathartics.It is this kind of to rush down
Medicine can lubricate intestinal wall, softening stool, make excrement be easy to discharge, wherein atoleine take orally or bowel lavage after do not absorbed, while can
To hinder the absorption of moisture in intestines, it is comparatively ideal laxative, but prolonged application may interfere with vitamin A, D, K and calcium, phosphorus
Absorb.Although the analogous components such as magnesium sulfate, sorbierite can promote to drain in enema at present, long-time service can cause intestinal wall
It is more and more weaker to the sensitiveness of stimulation, cause dependence, form a vicious circle.And the components such as magnesium sulfate, sorbierite make
It is serious to obtain intestinal wall dehydration, intestinal mucosa unprotect is acted on.Simple glycerine side effect is low, but lubrication intestinal wall effect is small, to just
The effect of secret, differs.
Chinese patent 201310094416X discloses one kind and releives constipation, digestive compound essential oil, by happy rat-tail
The advantages of five kinds of grass, nutmeg, fennel, black pepper and Sweet Almond Oil essential oils are mixed well and are made, the compound essential oil be：Collect happy rat-tail
The effect of grass, nutmeg, fennel, black pepper and Sweet Almond Oil in one, and it is mutually coordinated, complement each other, heighten the effect of a treatment, be allowed to
Have the function of to releive constipation, help digest.Chinese patent 2016100652235 discloses a kind of system for the Chinese medicine dripping pills for treating constipation
Matrix is made in Preparation Method, polyethylene glycol water-bath dissolving, adds the mixed of fructus cannabis oil and Cassia seed oil into matrix under stirring
Compound, stirs evenly, and dripping pill liquid is made, and the matrix is 4-8 times of fructus cannabis oil and cassia seed oil mixture gross weight；Will
Dripping pill liquid, with the drop speed of 30-60 drops per minute, is instilled in the cooling oil tubulation equipped with temperature gradient under the conditions of 70-80 DEG C,
Dripping pill is made, centrifugation removes cooling oil, and to obtain the final product, the Chinese medicine dripping pills are curative for effect reliable, effective for treating constipation.The prior art
In, on the pharmaceutical composition of present invention treatment constipation, it yet there are no report.
The content of the invention
First purpose of the present invention is to be directed to deficiency of the prior art, there is provided a kind of medicine group of external curing constipation
Compound.
Second object of the present invention is to be directed to deficiency of the prior art, there is provided the use of pharmaceutical composition as described above
On the way.
To realize above-mentioned first purpose, the present invention adopts the technical scheme that：
A kind of pharmaceutical composition of external curing constipation, is made of the raw material of parts by weight as described below：Apricot kernel oil 20-30
Part, 15-25 parts of honey, 20-30 parts of fructus cannabis oil, 7-13 parts of siritch, 7-13 parts of betel oil, 7-13 parts of longan gravy.
As the present invention a preferred embodiment, described pharmaceutical composition by parts by weight as described below raw material system
Into：23-27 parts of apricot kernel oil, 18-22 parts of honey, 23-27 parts of fructus cannabis oil, 9-11 parts of siritch, 9-11 parts of betel oil, arillus longan
9-11 parts of juice.
As the present invention a preferred embodiment, described pharmaceutical composition by parts by weight as described below raw material system
Into：25 parts of apricot kernel oil, 20 parts of honey, 25 parts of fructus cannabis oil, 10 parts of siritch, 10 parts of betel oil, 10 parts of longan gravy.
As the preferred embodiment of the present invention, the honey is nectar, mannan or the mixing of the two.
To realize above-mentioned second purpose, the present invention adopts the technical scheme that：
As above application of any composition in the medicine for preparing treatment constipation.
As the preferred embodiment of the present invention, the medicine is enema.By weight as described above
Pharmaceutical composition adds container and mixes, and carries out sterilization treatment, then adds in disposable transfusion device, rectally.
《Compendium of Materia Medica》Record：Honey is sweet flat nontoxic, cures mainly trusted subordinate's perverse trend, all frightened, epilepsy convulsion, five viscera settling various symptims and signs of deficiency, QI invigorating
Bowl spares, analgesic antidotal, except many diseases, and hundred medicines.Honey can promote except playing the role of ease constipation laxation, many research report honey
The healing of wound mucous membrane, and concentration is more high more effective；There is antibacterial, anti-inflammatory, and its antibacterial activity does not produce drug resistance
The danger of property.
Fructus cannabis oil can not only soften stool, and the slight excited intestinal tube of energy, increase the wriggling of intestinal tube.
Almond can relieving cough and asthma, moistening lung defaecation.Research finds almond oil energy anti-inflammatory and antalgic, and external application can effectively treat sore
Ulcer, wound healing.
Flax exists《Sheng Nong's herbal classic》In cure mainly " empty in wound to win, to mend in five, benefiting energy, long muscle, life essence-filling, marrow-benefittings ".Flax
Oily external application can effectively alleviate the breakage of anal skin, redness is even festered.
Betel oil is present in betel nut seed, and safe range is big, has no toxic side effect.Studies have found that betel oil have anti-inflammatory and
The effect suppressed growth of microorganism.
Arillus longan first recorded in《Sheng Nong's herbal classic》, its is sweet in flavor mild-natured nontoxic.Modern study confirms arillus longan flooding agent to dysentery
Shigella has inhibitory action.
The invention has the advantages that：
1st, the present invention passes through for the pharmaceutical composition of constipation and screens, mutually coordinated performance greatest treatment efficacy between each medicine, medicine
Effect is lasting, has no toxic side effect, is worthy of popularization.
2nd, pharmaceutical composition of the invention has the effect of good for constipation, and it is swollen can to significantly improve constipation patient belly
Full, constipation symptom, high efficiency.
3rd, enema of the invention have have no toxic side effect, preparation method it is simple, with it is simple and easy to do the advantages that, suitable for length
Phase uses, and is a kind of medicine for safely and effectively treating constipation, has a good application prospect.
Embodiment
The invention will be further elucidated with reference to specific embodiments.It is to be understood that these embodiments are merely to illustrate this hair
It is bright rather than limit the scope of the invention.In addition, it should also be understood that, after the content of the invention recorded has been read, art technology
Personnel can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Fixed scope.
Embodiment 1 treats the pharmaceutical composition (one) of constipation
Bulk pharmaceutical chemicals are taken by weight：25 parts of apricot kernel oil, 20 parts of mannan, 25 parts of fructus cannabis oil, 10 parts of siritch, betel oil
10 parts, 10 parts of longan gravy.
Embodiment 2 treats the pharmaceutical composition (two) of constipation
Bulk pharmaceutical chemicals are taken by weight：20 parts of apricot kernel oil, 15 parts of nectar, 20 parts of fructus cannabis oil, 13 parts of siritch, betel oil 13
Part, 13 parts of longan gravy.
Embodiment 3 treats the pharmaceutical composition (three) of constipation
Bulk pharmaceutical chemicals are taken by weight：30 parts of apricot kernel oil, 25 parts of nectar, 30 parts of fructus cannabis oil, 7 parts of siritch, betel oil 7
Part, 7 parts of longan gravy.
Embodiment 4 treats the pharmaceutical composition (four) of constipation
Bulk pharmaceutical chemicals are taken by weight：20 parts of apricot kernel oil, 15 parts of nectar, 30 parts of fructus cannabis oil, 13 parts of siritch, betel oil 7
Part, 7 parts of longan gravy.
Embodiment 5 treats the pharmaceutical composition (five) of constipation
Bulk pharmaceutical chemicals are taken by weight：30 parts of apricot kernel oil, 25 parts of mannan, 20 parts of fructus cannabis oil, 7 parts of siritch, betel oil
13 parts, 13 parts of longan gravy.
Embodiment 6 treats the pharmaceutical composition (six) of constipation
Bulk pharmaceutical chemicals are taken by weight：30 parts of apricot kernel oil, 15 parts of mannan, 30 parts of fructus cannabis oil, 7 parts of siritch, betel oil
13 parts, 7 parts of longan gravy.
Embodiment 7 treats the pharmaceutical composition (seven) of constipation
Bulk pharmaceutical chemicals are taken by weight：20 parts of apricot kernel oil, 25 parts of mannan, 20 parts of fructus cannabis oil, 13 parts of siritch, betel oil
7 parts, 13 parts of arillus longan.
Embodiment 8 treats the pharmaceutical composition (eight) of constipation
Bulk pharmaceutical chemicals are taken by weight：27 parts of apricot kernel oil, 22 parts of nectar, 27 parts of fructus cannabis oil, 9 parts of siritch, betel oil 9
Part, 9 parts of longan gravy.
Embodiment 9 treats the pharmaceutical composition (nine) of constipation
Bulk pharmaceutical chemicals are taken by weight：23 parts of apricot kernel oil, 18 parts of nectar, 23 parts of fructus cannabis oil, 11 parts of siritch, betel oil 11
Part, 11 parts of longan gravy.
Embodiment 10 treats the pharmaceutical composition (ten) of constipation
Bulk pharmaceutical chemicals are taken by weight：27 parts of apricot kernel oil, 22 parts of nectar, 23 parts of fructus cannabis oil, 9 parts of siritch, betel oil 11
Part, 11 parts of longan gravy.
Embodiment 11 treats the pharmaceutical composition (11) of constipation
Bulk pharmaceutical chemicals are taken by weight：23 parts of apricot kernel oil, 18 parts of nectar, 27 parts of fructus cannabis oil, 11 parts of siritch, betel oil 9
Part, 9 parts of longan gravy.
Embodiment 12 treats the pharmaceutical composition (12) of constipation
Bulk pharmaceutical chemicals are taken by weight：23 parts of apricot kernel oil, 22 parts of nectar, 23 parts of fructus cannabis oil, 11 parts of siritch, betel oil 9
Part, 11 parts of longan gravy.
Embodiment 13 treats the pharmaceutical composition (13) of constipation
Bulk pharmaceutical chemicals are taken by weight：27 parts of apricot kernel oil, 18 parts of nectar, 27 parts of fructus cannabis oil, 9 parts of siritch, betel oil 11
Part, 9 parts of longan gravy.
The medicine composite for curing constipation clinical test of the present invention of embodiment 14
1 data and method
In October, 2013 is selected to constipation patient 181 between in August, 2017, male 86, women 95, age 18-70
Year, course of disease 2-10.All patients are randomly divided into four groups, and each group gender, age, course of disease etc. are comparable without significant difference.
2 diagnostic criteria
Announced with reference to Ministry of Health of the People's Republic of China《New Chinese medicine clinical guidance principle》Formulation standard is as follows：Stool
Matter is hard, excludes difficulty, and stool amount very little, in the case where not applying purgatives medicine thing, excrement is emptied in 7 days without awareness of defecation or spontaneity
It is not above 2 times, anal orifice and rectal intestine has obstruction or blocks sense.The organic disease of colon is excluded through barium enema examination, colonoscopy
Become.
3 treatment methods
Treat one group：25 parts of apricot kernel oil, 20 parts of mannan, 25 parts of fructus cannabis oil, 10 parts of siritch, 10 parts of betel oil, dragon
10 parts of eye meat juice.Sterilization treatment is mixed, is heated to 37-39 DEG C, by disposable transfusion device rectally, 200ml/ bowel lavage, 1
Times/day, ten days as a treatment course, are used in conjunction 2 courses for the treatment of.Require to establish rational diet and habits and customs during treatment, eat vegetable more
Dish, fruit, the coarse cereals of coarse more slags, the food of optional sliding matter profit are few to sit more dynamic, timing defecation.
Treat two groups：15 parts of apricot kernel oil, 10 parts of nectar, 15 parts of fructus cannabis oil, 15 parts of siritch.Sterilization treatment is mixed, is added
Heat is to 37-39 DEG C, and by disposable transfusion device rectally, 200ml/ bowel lavage, 1 times/day, ten days as a treatment course, are used in conjunction 2
A course for the treatment of.Require to establish rational diet and habits and customs during treatment, eat veterinary antibiotics, the coarse cereals of coarse more slags more, select
Property slide the food of matter profit, it is few to sit more dynamic, timing defecation.
Treat three groups：15 parts of apricot kernel oil, 10 parts of nectar, 15 parts of betel oil, 15 parts of longan gravy, mixes sterilization treatment, adds
Heat is to 37-39 DEG C, and by disposable transfusion device rectally, 200ml/ bowel lavage, 1 times/day, ten days as a treatment course, are used in conjunction 2
A course for the treatment of.Require to establish rational diet and habits and customs during treatment, eat veterinary antibiotics, the coarse cereals of coarse more slags more, select
Property slide the food of matter profit, it is few to sit more dynamic, timing defecation.
Control group：Oral hemp seed soft capsule, 2 tablets each time, 2 times every time, is used in conjunction 3 weeks.
4 observation of curative effect
4.1 observation index
Before treatment and after treatment end, naked eyes, excrement inspection observation patient times of defecation, quality, while observe patient and lack abdomen
Make situations such as swollen, by mild symptoms, in, again respectively remember 1,3,5 point.
4.2 standards of grading
Stool interval：Less than 6 days, 1 point is remembered；6-9 days, remember 3 points；More than 9 days, 5 points are remembered.
Shit quality：Firmly, 1 point is remembered；It is very hard, remember 3 points；Hard sphere, remembers 5 points.
Belly turgor：Slightly, 1 point is remembered；It can endure, remember 3 points；It is difficult to endure, remembers 5 points.
4.3 criterion of therapeutical effect
It is effective：The symptom of stool 1~2 time/1~2 day, difficult defecation and merging all disappears；Effectively：Times of defecation is relatively controlled
There is increase before treatment, the symptom partial disappearance of difficult defecation and merging or be clearly better；It is invalid：After treatment with above symptom before treatment
Without significant change.
5 treatment results
(1) four group of patient clinical curative effect compares
The results are shown in Table 1, treatment one group effective 30, effective 18, total effective rate 100%；Treat two groups effective 14
Example, effective 19, invalid 13, total effective rate 71.7%；Treat three groups effective 10, effective 20, invalid 12, it is total effectively
Rate 71.4%；Effective 12 of control group, effective 17, invalid 16, total effective rate 64.4%.It is notable to treat one group of total effective rate
Higher than control group, illustrating the pharmaceutical composition of the present invention has effects that significantly to treat constipation.Treat one group of total effective rate and
Obvious effective rate is significantly better than three groups of two groups for the treatment of and treatment, illustrates the pharmaceutical composition of the present invention and has the advantages that significant effect.
Clinical efficacy comparison after 1 four groups of patient's treatments of table
| Group | Number of cases | It is effective | Effectively | It is invalid | Total effective rate |
| Control group | 45 | 12 | 17 | 16 | 29 (64.4%) |
| Treat one group | 48 | 30 | 18 | 0 | 48 (100%) |
| Treat two groups | 46 | 14 | 19 | 13 | 33 (71.7%) |
| Treat three groups | 42 | 10 | 20 | 12 | 30 (71.4%) |
(2) four groups of tients with constipation's cardinal symptom integral contrasts
The results are shown in Table 2, treat interval of defecating after one group of patient treatment, shit quality, belly turgor symptom integral compared with
(P is significantly reduced before treatment<0.01) constipation symptom of patient can be effectively improved by, illustrating the pharmaceutical composition of the present invention.Treatment one
Defecate interval, shit quality, belly turgor symptom integral (P statistically significant compared with the control group after group patient's treatment<
0.05), illustrate that the pharmaceutical composition of the present invention is more preferable for the improvement of constipation symptom.
The pretherapy and post-treatment constipation cardinal symptom integral contrast of 2 four groups of patients of table
Note：Compared with before treatment, * P<0.05, * * P<0.01.Compared with the control group#P<0.05,##P<0.05。
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the method for the present invention is not departed from, can also make some improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (6)
1. a kind of pharmaceutical composition of external curing constipation, it is characterised in that be made of the raw material of parts by weight as described below：Almond
It is 20-30 parts oily, 15-25 parts of honey, 20-30 parts of fructus cannabis oil, 7-13 parts of siritch, 7-13 parts of betel oil, longan gravy 7-13
Part.
2. the pharmaceutical composition of constipation is treated according to claim 1, it is characterised in that by the raw material of parts by weight as described below
It is made：23-27 parts of apricot kernel oil, 18-22 parts of honey, 23-27 parts of fructus cannabis oil, 9-11 parts of siritch, 9-11 parts of betel oil, longan
9-11 parts of gravy.
3. the pharmaceutical composition of constipation is treated according to claim 1, it is characterised in that by the raw material of parts by weight as described below
It is made：25 parts of apricot kernel oil, 20 parts of honey, 25 parts of fructus cannabis oil, 10 parts of siritch, 10 parts of betel oil, 10 parts of longan gravy.
4. the pharmaceutical composition of constipation is treated according to claim 1, it is characterised in that the honey is nectar, mannan
Or the mixing of the two.
5. application of any compositions of claim 1-4 in the medicine for preparing treatment constipation.
6. application according to claim 5, it is characterised in that the medicine is enema.
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Cited By (1)
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