CN101703648B - Chinese patent medicament for treating hematochezia and preparation method thereof - Google Patents
Chinese patent medicament for treating hematochezia and preparation method thereof Download PDFInfo
- Publication number
- CN101703648B CN101703648B CN2009100243661A CN200910024366A CN101703648B CN 101703648 B CN101703648 B CN 101703648B CN 2009100243661 A CN2009100243661 A CN 2009100243661A CN 200910024366 A CN200910024366 A CN 200910024366A CN 101703648 B CN101703648 B CN 101703648B
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- portions
- blood
- standby
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a Chinese patent medicament for treating hematochezia and a preparation method thereof. The Chinese patent medicament for treating the hematochezia is prepared from the following components in part by weight: 70 to 90 parts of pagodatree pod, 65 to 80 parts of India madder root, 65 to 85 parts of sanchi, 30 to 50 parts of dragon's blood, 45 to 65 parts of myrrh, 20 to 40 parts of rhubarb, 20 to 35 parts of golden thread and 10 to 30 parts of liquoric root through the steps of decocting, concentrating, crushing and granulating. Based on the theory of Chinese medicinal formulas, the Chinese patent medicament has the effects of clearing away heat to stop bleeding and relieving swelling to stop pain by extracting essence, and has the characteristics of small prescription, simple preparation method, low processing cost, obvious curative effect and no toxic or side effect.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine and preparation method thereof, Chinese patent medicine that particularly a kind of treatment is had blood in stool and preparation method thereof.
Technical background
Having blood in stool has another name called " hemafecia ", " hematochezia ", " rushing down blood ", with hemafecia or to descend aquatic foods after an action of the bowels be feature.Be common in that ulcer of upper digestive tract is hemorrhage, gastrointestinal polyp, enteric hemorrhage, tumor, and some hematopathys, acute infection medicine, parasite etc.What hemorrhoid breakage, anal fissure, anal sinusitis, nodus hemorrhoidalis intestinal mucosal injury caused has blood in stool, defecate soft and shaping or scleroma, blood is attached to the feces surface, the rectal bleeding followed by defecation that has, the bleeding after defecation that has, color is scarlet mostly, the dim red muddiness that also has, blood volume is not to the utmost dripping for a long time, and anus mouth pain increases the weight of greatly after an action of the bowels, brings great misery for patient's work and life.The Western medicine that treatment is at present had blood in stool has tablet, injection etc., injection exists injecting drug use can form the thrombosis local necrosis, heat, acid, alkali or heavy metal salt can make active decline and ineffective, the patient who has is prone to that allergy etc. is bad brings out disease, the Western medicine of other multiple dosage form such as tablet is held time short and the conventional amount used effect is unsatisfied with more, then toxic and side effects is obvious again to strengthen consumption, and most drug prices are expensive brings very large economy burden for patient and family members, therefore make clinical be difficult to satisfied.Though the traditional Chinese medical science has many treatments prescription of having blood in stool, but it is subjected to the restriction of some row such as dosage form, technology, though the Chinese medicine decoction effect is fast, curative effect is high, but working costs, oral bitter in the mouth, carry inconvenience, though the medicine pill part has been covered the bad flavor of smelling of medicine, but effect slowly, though the Chinese medicine oral liquid onset is very fast, has complex manufacturing, the loaded down with trivial details defective of preparation.And most Chinese medicines are cold and cool because of the property of medicine, and body empty Deficiency and coldness of spleen and stomach patient then be not suitable for again.
The patent No.: ZL200510096362.6; Denomination of invention: a kind of medicine for the treatment of metrorrhagia, hematemesis and having blood in stool, patent of invention discloses a kind of extraction and capsule preparation method thereof for the treatment of metrorrhagia, hematemesis and the medicine of having blood in stool and capsule prescription and active ingredient, prescription 14 flavor medical materials, therapeutic effect is general, and it is bigger that the patient bears economic pressures.
Summary of the invention
In order to overcome the defective of above-mentioned prior art, the object of the present invention is to provide Chinese patent medicine that a kind of treatment has blood in stool and preparation method thereof, by traditional Chinese medical science prescription theory, skim the cream off milk, make its performance clearing away heat to stop bleeding, the effect of reducing swelling and alleviating pain has the advantages that prescription is little, preparation method is simple, processing cost is low, evident in efficacy, without any side effects.
In order to achieve the above object, technical scheme of the present invention is achieved in that
The Chinese patent medicine that a kind of treatment is had blood in stool, its raw material weight constituent comprises: 70～90 parts of the Fructuss Sophorae, 65～80 parts in Radix Rubiae, 65～85 parts of Radix Notoginseng, 30～50 parts of Sanguis Draxonis, 45～65 parts of Myrrhas, 20～40 parts of Radix Et Rhizoma Rhei, 20～35 parts of Rhizoma Coptidis, 10～30 parts in Radix Glycyrrhizae.
The Chinese patent medicine that a kind of treatment is had blood in stool, its raw material weight constituent is: 70～90 parts of the Fructuss Sophorae, 65～80 parts in Radix Rubiae, 65～85 parts of Radix Notoginseng, 30～50 parts of Sanguis Draxonis, 45～65 parts of Myrrhas, 20～40 parts of Radix Et Rhizoma Rhei, 20～35 parts of Rhizoma Coptidis, 10～30 parts in Radix Glycyrrhizae.
The Chinese patent medicine that a kind of treatment is had blood in stool, its raw material weight constituent comprises: 75～85 parts of the Fructuss Sophorae, 65～75 parts in Radix Rubiae, 70～80 parts of Radix Notoginseng, 35～45 parts of Sanguis Draxonis, 50～60 parts of Myrrhas, 25～35 parts of Radix Et Rhizoma Rhei, 25～35 parts of Rhizoma Coptidis, 15～25 parts in Radix Glycyrrhizae.
The Chinese patent medicine that a kind of treatment is had blood in stool, its raw material weight constituent is: 75～85 parts of the Fructuss Sophorae, 65～75 parts in Radix Rubiae, 70～80 parts of Radix Notoginseng, 35～45 parts of Sanguis Draxonis, 50～60 parts of Myrrhas, 25～35 parts of Radix Et Rhizoma Rhei, 25～35 parts of Rhizoma Coptidis, 15～25 parts in Radix Glycyrrhizae.
Preparation method step of the present invention is as follows:
The first step, 70～90 parts of Fructuss Sophorae, 65～80 portions of Radix Rubiaes, 20～40 parts of Radix Et Rhizoma Rhei, 20～35 portions of Rhizoma Coptidis, 10～30 portions of Radix Glycyrrhizaes put together add 3～8 times of amounts of drug weight 70～80% ethanol with 75-85 ℃ of reflux 1～3 hour, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 8～12 times of amounts of drug weight decocted 1～3 hour with 90～100 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,60～80 ℃ are condensed into relative density and are determined as 1.35～1.38 thick paste at 60 ℃, 60～80 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 65～85 portions of Radix Notoginseng, 30～50 parts of Sanguis Draxonis, 45～65 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step; with the standby fine powder mix homogeneously of the 3rd step with the 4th step; add 70～80% ethanol that account for mixed powder weight 15～20%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 60～80 ℃ in hothouse was dried by the fire 1～2 hour; cross 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Preparation method step of the present invention is as follows:
The first step, 75～85 parts of Fructuss Sophorae, 65～75 portions of Radix Rubiaes, 25～35 parts of Radix Et Rhizoma Rhei, 25～35 portions of Rhizoma Coptidis, 15～25 portions of Radix Glycyrrhizaes put together add 3～8 times of amounts of drug weight 70～80% ethanol with 75-85 ℃ of reflux 1～3 hour, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 8～12 times of amounts of drug weight decocted 1～3 hour with 90～100 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,60～80 ℃ are condensed into relative density and are determined as 1.35～1.38 thick paste at 60 ℃, 60～80 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 70～80 portions of Radix Notoginseng, 35～45 parts of Sanguis Draxonis, 50～60 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step; with the standby fine powder mix homogeneously of the 3rd step with the 4th step; add 70～80% ethanol that account for mixed powder weight 15～20%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 60～80 ℃ in hothouse was dried by the fire 1～2 hour; cross 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Above-mentioned raw material of Chinese medicine is through dialectical compatibility, complement each other using, thereby the effect of having given play to effectively reached the purpose that treatment is had blood in stool.Fructus Sophorae hardship, cold among the we is returned liver, large intestine channel in the present invention's prescription, clearing away heat-fire, and cooling blood for hemostasis, kind bowel relieving heat, Radix Rubiae hardship, cold, cooling blood for hemostasis, promoting blood circulation to disperse blood clots and relieves pain is we's monarch drug altogether; And the little hardship of Radix Notoginseng is gone into the stomach warp, removing stasis to stop bleeding, and the characteristic of stopping blooding and not staying the stasis of blood is arranged; Sanguis Draxonis is sweet salty, but promoting blood circulation to remove blood stasis pain relieving for oral administration also has the magical effect of stopping blooding and not staying the stasis of blood, the Myrrha promoting blood circulation and stopping pain, detumescence and promoting granulation, and the relatively length of " blood looses ", Radix Notoginseng, Sanguis Draxonis, Myrrha and the Fructus Sophorae, Radix Rubiae compatibility are arranged, strengthen its promoting blood flow and remove blood stasis and stop bleeding, the effect of reducing swelling and alleviating pain is we's ministerial drug; Fang Zhongzuo returns spleen, stomach, large intestine channel with Radix Et Rhizoma Rhei hardship, cold, and clearing away heat-fire is washed away the intestines and stomach, it is descending to draw heat simultaneously, makes intestinal heat, and stagnant being dropped helped with Rhizoma Coptidis hardship, cold again, return stomach, large intestine channel, the power of heat-clearing and toxic substances removing is strong, cooperates Radix Et Rhizoma Rhei that intestinal poison stagnant heat is dropped; Radix Glycyrrhizae is sweet flat, goes into the taste warp, relieving spasm to stop pain is arranged, the effect of coordinating the actions of various ingredients in a prescription.Full side eight flavors, compatibility is proper, tool clearing away heat to stop bleeding altogether, the effect of reducing swelling and alleviating pain, make intestinal heat clear, be retarded by silt remove, swell and ache disappear, hemorrhage ending, be used for intestinal heat and hold having blood in stool due to the stasis of blood under the arm.
The specific embodiment
Embodiment 1
The raw material weight composition of present embodiment comprises: 70 parts of Fructuss Sophorae, 60 portions of Radix Rubiaes, 65 portions of Radix Notoginseng, 30 parts of Sanguis Draxonis, 45 parts of Myrrhas, 20 parts of Radix Et Rhizoma Rhei, 20 portions of Rhizoma Coptidis, 10 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment is: 70 parts of Fructuss Sophorae, 60 portions of Radix Rubiaes, 65 portions of Radix Notoginseng, 30 parts of Sanguis Draxonis, 45 parts of Myrrhas, 20 parts of Radix Et Rhizoma Rhei, 20 portions of Rhizoma Coptidis, 10 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 70 parts of Fructuss Sophorae, 60 portions of Radix Rubiaes, 20 parts of Radix Et Rhizoma Rhei, 20 portions of Rhizoma Coptidis, 10 portions of Radix Glycyrrhizaes put together add 3 times of amounts of drug weight 75% ethanol with 80 ℃ of reflux 2 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 10 times of amounts of drug weight decocted 2 hours with 92 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,65 ℃ are condensed into relative density and are determined as 1.36 thick paste at 60 ℃, 68 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 65 portions of Radix Notoginseng, 30 parts of Sanguis Draxonis, 45 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step; with the standby fine powder mix homogeneously of the 3rd step with the 4th step; add 75% ethanol that accounts for mixed powder weight 18%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 65 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 2
The raw material weight composition of present embodiment is: 72 parts of Fructuss Sophorae, 62 portions of Radix Rubiaes, 68 portions of Radix Notoginseng, 32 parts of Sanguis Draxonis, 48 parts of Myrrhas, 22 parts of Radix Et Rhizoma Rhei, 22 portions of Rhizoma Coptidis, 12 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment comprises: 72 parts of Fructuss Sophorae, 62 portions of Radix Rubiaes, 68 portions of Radix Notoginseng, 32 parts of Sanguis Draxonis, 48 parts of Myrrhas, 22 parts of Radix Et Rhizoma Rhei, 22 portions of Rhizoma Coptidis, 12 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 72 parts of Fructuss Sophorae, 62 portions of Radix Rubiaes, 22 parts of Radix Et Rhizoma Rhei, 22 portions of Rhizoma Coptidis, 12 portions of Radix Glycyrrhizaes put together add 4 times of amounts of drug weight 70% ethanol with 85 ℃ of reflux 3 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 8 times of amounts of drug weight decocted 2.5 hours with 98 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,64 ℃ are condensed into relative density and are determined as 1.35 thick paste at 60 ℃, 66 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 68 portions of Radix Notoginseng, 32 parts of Sanguis Draxonis, 48 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step with the standby fine powder mix homogeneously of the 3rd step with the 4th step, added 70% ethanol that accounts for mixed powder weight 17%, made soft material; granulate with 20 eye mesh screens in granulator, the temperature with 60 ℃ in hothouse was dried by the fire 1 hour, crossed 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 3
The raw material weight composition of present embodiment comprises: 75 parts of Fructuss Sophorae, 65 portions of Radix Rubiaes, 70 portions of Radix Notoginseng, 35 parts of Sanguis Draxonis, 50 parts of Myrrhas, 25 parts of Radix Et Rhizoma Rhei, 25 portions of Rhizoma Coptidis, 15 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment is: 75 parts of Fructuss Sophorae, 65 portions of Radix Rubiaes, 70 portions of Radix Notoginseng, 35 parts of Sanguis Draxonis, 50 parts of Myrrhas, 25 parts of Radix Et Rhizoma Rhei, 25 portions of Rhizoma Coptidis, 15 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 75 parts of Fructuss Sophorae, 65 portions of Radix Rubiaes, 25 parts of Radix Et Rhizoma Rhei, 25 portions of Rhizoma Coptidis, 15 portions of Radix Glycyrrhizaes put together add 5 times of amounts of drug weight 71% ethanol with 84 ℃ of reflux 2.5 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 8.5 times of amounts of drug weight decocted 1.5 hours with 97 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,67 ℃ are condensed into relative density and are determined as 1.37 thick paste at 60 ℃, 64 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 70 portions of Radix Notoginseng, 35 parts of Sanguis Draxonis, 50 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step with the standby fine powder mix homogeneously of the 3rd step with the 4th step, added 72% ethanol that accounts for mixed powder weight 16%, made soft material; granulate with 20 eye mesh screens in granulator, the temperature with 62 ℃ in hothouse was dried by the fire 2 hours, crossed 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 4
The raw material weight composition of present embodiment is: 78 parts of Fructuss Sophorae, 68 portions of Radix Rubiaes, 72 portions of Radix Notoginseng, 38 parts of Sanguis Draxonis, 52 parts of Myrrhas, 28 parts of Radix Et Rhizoma Rhei, 28 portions of Rhizoma Coptidis, 18 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment comprises: 78 parts of Fructuss Sophorae, 68 portions of Radix Rubiaes, 72 portions of Radix Notoginseng, 38 parts of Sanguis Draxonis, 52 parts of Myrrhas, 28 parts of Radix Et Rhizoma Rhei, 28 portions of Rhizoma Coptidis, 18 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 78 parts of Fructuss Sophorae, 68 portions of Radix Rubiaes, 28 parts of Radix Et Rhizoma Rhei, 28 portions of Rhizoma Coptidis, 18 portions of Radix Glycyrrhizaes put together add 6 times of amounts of drug weight 72% ethanol with 83 ℃ of reflux 1.5 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 9 times of amounts of drug weight decocted 1 hour with 95 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,63 ℃ are condensed into relative density and are determined as 1.38 thick paste at 60 ℃, 60 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 72 portions of Radix Notoginseng, 38 parts of Sanguis Draxonis, 52 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step; with the standby fine powder mix homogeneously of the 3rd step with the 4th step; add 71% ethanol that accounts for mixed powder weight 15%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 68 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 5
The raw material weight composition of present embodiment is: 80 parts of Fructuss Sophorae, 70 portions of Radix Rubiaes, 75 portions of Radix Notoginseng, 40 parts of Sanguis Draxonis, 55 parts of Myrrhas, 30 parts of Radix Et Rhizoma Rhei, 30 portions of Rhizoma Coptidis, 20 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment comprises: 80 parts of Fructuss Sophorae, 70 portions of Radix Rubiaes, 75 portions of Radix Notoginseng, 40 parts of Sanguis Draxonis, 55 parts of Myrrhas, 30 parts of Radix Et Rhizoma Rhei, 30 portions of Rhizoma Coptidis, 20 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 80 parts of Fructuss Sophorae, 70 portions of Radix Rubiaes, 30 parts of Radix Et Rhizoma Rhei, 30 portions of Rhizoma Coptidis, 20 portions of Radix Glycyrrhizaes put together add 7 times of amounts of drug weight 73% ethanol with 82 ℃ of reflux 1 hour, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 10.5 times of amounts of drug weight decocted 3 hours with 96 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,68 ℃ are condensed into relative density and are determined as 1.36 thick paste at 60 ℃, 70 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 75 portions of Radix Notoginseng, 40 parts of Sanguis Draxonis, 55 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step with the standby fine powder mix homogeneously of the 3rd step with the 4th step, added 80% ethanol that accounts for mixed powder weight 19%, made soft material; granulate with 20 eye mesh screens in granulator, the temperature with 70 ℃ in hothouse was dried by the fire 1 hour, crossed 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 6
The raw material weight composition of present embodiment comprises: 82 parts of Fructuss Sophorae, 72 portions of Radix Rubiaes, 78 portions of Radix Notoginseng, 42 parts of Sanguis Draxonis, 58 parts of Myrrhas, 32 parts of Radix Et Rhizoma Rhei, 32 portions of Rhizoma Coptidis, 22 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment is: 82 parts of Fructuss Sophorae, 72 portions of Radix Rubiaes, 78 portions of Radix Notoginseng, 42 parts of Sanguis Draxonis, 58 parts of Myrrhas, 32 parts of Radix Et Rhizoma Rhei, 32 portions of Rhizoma Coptidis, 22 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 82 parts of Fructuss Sophorae, 72 portions of Radix Rubiaes, 32 parts of Radix Et Rhizoma Rhei, 32 portions of Rhizoma Coptidis, 22 portions of Radix Glycyrrhizaes put together add 8 times of amounts of drug weight 74% ethanol with 79 ℃ of reflux 2 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 11 times of amounts of drug weight decocted 2 hours with 94 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,80 ℃ are condensed into relative density and are determined as 1.35 thick paste at 60 ℃, 72 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 78 portions of Radix Notoginseng, 42 parts of Sanguis Draxonis, 58 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step with the standby fine powder mix homogeneously of the 3rd step with the 4th step, added 78% ethanol that accounts for mixed powder weight 20%, made soft material; granulate with 20 eye mesh screens in granulator, the temperature with 72 ℃ in hothouse was dried by the fire 2 hours, crossed 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 7
The raw material weight composition of present embodiment is: 85 parts of Fructuss Sophorae, 75 portions of Radix Rubiaes, 80 portions of Radix Notoginseng, 45 parts of Sanguis Draxonis, 60 parts of Myrrhas, 35 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 25 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment comprises: 85 parts of Fructuss Sophorae, 75 portions of Radix Rubiaes, 80 portions of Radix Notoginseng, 45 parts of Sanguis Draxonis, 60 parts of Myrrhas, 35 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 25 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 85 parts of Fructuss Sophorae, 75 portions of Radix Rubiaes, 35 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 25 portions of Radix Glycyrrhizaes put together add 3.5 times of amounts of drug weight 76% ethanol with 78 ℃ of reflux 3 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 11.5 times of amounts of drug weight decocted 2.5 hours with 90 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,60 ℃ are condensed into relative density and are determined as 1.37 thick paste at 60 ℃, 74 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 80 portions of Radix Notoginseng, 45 parts of Sanguis Draxonis, 60 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step; with the standby fine powder mix homogeneously of the 3rd step with the 4th step; add 76% ethanol that accounts for mixed powder weight 17%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 74 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 8
The raw material weight composition of present embodiment comprises: 86 parts of Fructuss Sophorae, 76 portions of Radix Rubiaes, 82 portions of Radix Notoginseng, 46 parts of Sanguis Draxonis, 62 parts of Myrrhas, 36 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 26 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment is: 86 parts of Fructuss Sophorae, 76 portions of Radix Rubiaes, 82 portions of Radix Notoginseng, 46 parts of Sanguis Draxonis, 62 parts of Myrrhas, 36 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 26 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 86 parts of Fructuss Sophorae, 76 portions of Radix Rubiaes, 36 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 26 portions of Radix Glycyrrhizaes put together add 5.5 times of amounts of drug weight 77% ethanol with 77 ℃ of reflux 2.5 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 12 times of amounts of drug weight decocted 1.5 hours with 93 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,62 ℃ are condensed into relative density and are determined as 1.38 thick paste at 60 ℃, 76 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 82 portions of Radix Notoginseng, 46 parts of Sanguis Draxonis, 62 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step with the standby fine powder mix homogeneously of the 3rd step with the 4th step, added 77% ethanol that accounts for mixed powder weight 16%, made soft material; granulate with 20 eye mesh screens in granulator, the temperature with 76 ℃ in hothouse was dried by the fire 1 hour, crossed 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 9
The raw material weight composition of present embodiment is: 88 parts of Fructuss Sophorae, 78 portions of Radix Rubiaes, 84 portions of Radix Notoginseng, 48 parts of Sanguis Draxonis, 64 parts of Myrrhas, 38 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 28 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment comprises: 88 parts of Fructuss Sophorae, 78 portions of Radix Rubiaes, 84 portions of Radix Notoginseng, 48 parts of Sanguis Draxonis, 64 parts of Myrrhas, 38 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 28 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 88 parts of Fructuss Sophorae, 78 portions of Radix Rubiaes, 38 parts of Radix Et Rhizoma Rhei, 35 portions of Rhizoma Coptidis, 28 portions of Radix Glycyrrhizaes put together add 6.5 times of amounts of drug weight 78% ethanol with 76 ℃ of reflux 1.5 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 9 times of amounts of drug weight decocted 1 hour with 91 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,66 ℃ are condensed into relative density and are determined as 1.35 thick paste at 60 ℃, 78 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 84 portions of Radix Notoginseng, 48 parts of Sanguis Draxonis, 64 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step with the standby fine powder mix homogeneously of the 3rd step with the 4th step, added 74% ethanol that accounts for mixed powder weight 18%, made soft material; granulate with 20 eye mesh screens in granulator, the temperature with 78 ℃ in hothouse was dried by the fire 2 hours, crossed 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Embodiment 10
The raw material weight composition of present embodiment comprises: 90 parts of Fructuss Sophorae, 80 portions of Radix Rubiaes, 85 portions of Radix Notoginseng, 50 parts of Sanguis Draxonis, 65 parts of Myrrhas, 40 parts of Radix Et Rhizoma Rhei, 34 portions of Rhizoma Coptidis, 30 portions of Radix Glycyrrhizaes.
The raw material weight composition of present embodiment is: 90 parts of Fructuss Sophorae, 80 portions of Radix Rubiaes, 85 portions of Radix Notoginseng, 50 parts of Sanguis Draxonis, 65 parts of Myrrhas, 40 parts of Radix Et Rhizoma Rhei, 34 portions of Rhizoma Coptidis, 30 portions of Radix Glycyrrhizaes.
The preparation method of present embodiment may further comprise the steps:
The first step, 90 parts of Fructuss Sophorae, 80 portions of Radix Rubiaes, 40 parts of Radix Et Rhizoma Rhei, 34 portions of Rhizoma Coptidis, 30 portions of Radix Glycyrrhizaes put together add 7.5 times of amounts of drug weight 80% ethanol with 75 ℃ of reflux 2 hours, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby
In second step, the water that the medicinal residues in the step 1 is added 11 times of amounts of drug weight decocted 3 hours with 99 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use,
The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,69 ℃ are condensed into relative density and are determined as 1.37 thick paste at 60 ℃, 80 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby,
The 4th step, 85 portions of Radix Notoginseng, 50 parts of Sanguis Draxonis, 65 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby,
The 5th step; with the standby fine powder mix homogeneously of the 3rd step with the 4th step; add 73% ethanol that accounts for mixed powder weight 19%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 80 ℃ in hothouse was dried by the fire 1.5 hours; cross 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Clinical experiment
1, is subjected to the reagent thing: the embodiment of the invention 5 capsules, 300mg/ grain.
2, test objective: observe curative effect and dosage thereof that Drug therapy of the present invention is had blood in stool, observe clinical drug safety simultaneously.
3, EXPERIMENTAL DESIGN
3.1, the contrast medicine: cause recovering capsule, provide by thousand standing grain Pharmaceuticaies.
3.2, the case choice criteria
3.2.1, the diagnostic criteria of having blood in stool: during defecation or just, blood flows out from anus after an action of the bowels, or the feces surface is measured the amount doesn't matter with small amounts of blood.The color of having blood in stool is scarlet, can be bleed, spurting is hemorrhage, band blood or held clot etc. under the arm on the toilet paper; Also can be melena.The patient has following medical history or is diagnosed as following disease: 1. acute hemorrhagic necrotizing enteritis, chronic non-specific ulcerative colitis, anal and rectal diseases; 2. hemorrhoid; 3. gastrointestinal polyp, colon tumor; 4. digestive tract ulcer; 5. the disease of some general such as hematopathy, acute infectious disease, parasitic disease etc.
3.2.2, the case of participating in the experiment selects: (1) includes standard in: 1. meet the diagnostic criteria of having blood in stool; 2. the age is at 18～65 years old, and male or female is ready to be subjected to examination (medicine is free).(2) get rid of the case standard: 1. used in 2 weeks and relevant medicine or the therapy person of treatment primary disease curative effect; 2. gestation or women breast-feeding their children; 3. allergic constitution reaches multiple drug allergy person; 4. merge primary diseases such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system, may the person of affecting the treatment; 5. psychotic.
3.3, observation index
3.3.1, safety observes: (1) general health check-up project; (2) heart, liver, renal function.
3.3.2, observation of curative effect: the doing well,improving situation of having blood in stool.
3.4, medication (1) test group: 4/time of the embodiment of the invention 5 capsules, 3 times/day, oral; (2) matched group: cause 4/time of recovering capsules, 3 times/day, oral.
3.5, the course of treatment: 3 is 1 course of treatment, has blood in stool after finishing the 1st course of treatment fully to stop the person and add 1 course of treatment.To serve on 2 courses of treatment still the nonresponder use the other treatment scheme instead.
3.6, curative effect determinate standard: produce effects: fecal occult blood testing is turned out cloudy and hemorrhage simultaneous phenomenon obviously improves, and blood pressure is steady, pulse＜90 time/min, perusal does not have the blood streak; Effectively: defecating hemorrhagely stops substantially, still has color on the toilet paper; Invalid: defecate hemorrhage do not see be clearly better or increase the weight of.
3.7, statistical method: χ
2Check.
4, case data: choose case totally 136 examples that meet the standard of including in, 64 examples of wherein being in hospital, outpatient service 72 examples; Stomach, duodenal ulcer are accompanied 23 examples of having blood in stool, hemorrhoid (internal hemorrhoid, external hemorrhoid) 60 examples, acute hemorrhagic necrotizing enteritis 13 examples, chronic non-specific ulcerative colitis 16 examples, polyp of colon 13 examples, colon cancer, rectum cancer induced hematochezia 11 examples; Man's 84 examples, women 52 examples.Patient age is 20 years old～58 years old.According to situations such as patient's sex, age, the state of an illness, the course of disease follow equilibrium, at random, the principle of double blinding is divided into 2 groups of test group and matched groups, every group 68 example with the patient.
5, result of the test
5.1, safety observes: be subjected to the reagent thing to general health check-up project such as body weight, breathing, heart rate, blood pressure and important organ after one's own heart, functions such as liver, kidney are not all influential.
5.2, clinical efficacy: though finish the 1st course of treatment back test group effective percentage and matched group comparison no difference of science of statistics (P＞0.05 sees Table 1), the test group obvious effective rate is like bigger than matched group, and test group cure rate and obvious effective rate are seemingly also greater than matched group.Fully stop having blood in stool after the person appends the 2nd course of treatment, test group and matched group effective percentage no difference of science of statistics (table 2), two groups of total effective rates (2 courses of treatment) be no difference of science of statistics (table 2) also.
Curative effect after table 1 treatment 1 course of treatment
Compare * P＞0.05 with matched group
Table 2 curative effect after the 2nd course of treatment
Compare * P＞0.05 with matched group
6, conclusion (of pressure testing): 4/time of the embodiment of the invention 5 capsule orals, 3 times/day, can be used for treating having blood in stool that multiple digestive tract disease causes, curative effect is better than causing recovering capsule, and the embodiment of the invention 5 Capsules group obvious effective rates are higher than and cause the recovering capsule group in the test; The longlyest in the test serve on 6 days, do not find obvious adverse reaction.
Animal experiment
1, test objective: observe the reaction of the embodiment of the invention 5 capsule animal acute toxicities, measure animal median lethal dose(LD 50) or maximum tolerated dose.
2, animal: ICR strain mice, male and female dual-purpose, body weight 20 ± 2g.Provide by Xi'an Jiaotong University Medical College's Experimental Animal Center.The quality certification number: the moving card of Shan doctor word 08-004.
3, route of administration: gastric infusion.
4, test ambient temperature, humidity: 23～24 ℃ of room temperatures, relative humidity 66～70%.
5, method
5.1, trial test: the geometric progression series dosage disposable gastric infusion that divides into groups was observed 7 days, did not find minimum complete dead dosage.So formal test changes the survey maximum tolerated dose.
5.2, formal experiment: get 20 of ICR strain mices, male and female half and half are weighed and are used the picric acid marker number.Pour out and cause the health capsule medicated powder of having blood in stool, being made into maximum concentration (not stopping up the mouse stomach syringe needle) with distilled water is 38.4% suspension, and mice state on an empty stomach press the 0.4mL/10g body weight down and irritates stomach, irritates stomach the same day altogether 3 times (interval 4h).After the administration, mice is put into animal feeding room, and conventional feed is freely drunk water, and observes continuously 15.
5, result: test mice does not have death.Except that administration mice on the same day gets rid of the feces of the softer formability difference of quality, do not observe other physiology and dystropy.The prompting mice can tolerate the embodiment of the invention 5 capsule medicated powder gastric infusions of maximum concentration, heap(ed) capacity.
6, brief summary: the embodiment of the invention 5 capsule mice maximum tolerated doses are the 46.08g/kg body weight, are equivalent to clinical people and intend with dosage (768～1024 times (body weight for humans is by 60kg) of 2.7～3.6g/d).
Claims (8)
1. Chinese patent medicine that treatment is had blood in stool, it is characterized in that its raw material weight constituent is: 70～90 parts of the Fructuss Sophorae, 65～80 parts in Radix Rubiae, 65～85 parts of Radix Notoginseng, 30～50 parts of Sanguis Draxonis, 45～65 parts of Myrrhas, 20～40 parts of Radix Et Rhizoma Rhei, 20～35 parts of Rhizoma Coptidis, 10～30 parts in Radix Glycyrrhizae.
2. the Chinese patent medicine that a kind of treatment according to claim 1 is had blood in stool, its raw material weight constituent is: 75～85 parts of the Fructuss Sophorae, 65～75 parts in Radix Rubiae, 70～80 parts of Radix Notoginseng, 35～45 parts of Sanguis Draxonis, 50～60 parts of Myrrhas, 25～35 parts of Radix Et Rhizoma Rhei, 25～35 parts of Rhizoma Coptidis, 15～25 parts in Radix Glycyrrhizae.
3. the Chinese patent medicine that a kind of treatment according to claim 1 is had blood in stool, its raw material weight constituent is: 80 parts of the Fructuss Sophorae, 70 parts in Radix Rubiae, 75 parts of Radix Notoginseng, 40 parts of Sanguis Draxonis, 55 parts of Myrrhas, 30 parts of Radix Et Rhizoma Rhei, 30 parts of Rhizoma Coptidis, 20 parts in Radix Glycyrrhizae.
4. the Chinese patent medicine that a kind of treatment according to claim 1 is had blood in stool, its raw material weight constituent is: 82 parts of the Fructuss Sophorae, 72 parts in Radix Rubiae, 78 parts of Radix Notoginseng, 42 parts of Sanguis Draxonis, 58 parts of Myrrhas, 32 parts of Radix Et Rhizoma Rhei, 32 parts of Rhizoma Coptidis, 22 parts in Radix Glycyrrhizae.
5. the Chinese patent medicine that a kind of treatment according to claim 1 is had blood in stool, its raw material weight constituent is: 85 parts of the Fructuss Sophorae, 75 parts in Radix Rubiae, 80 parts of Radix Notoginseng, 45 parts of Sanguis Draxonis, 60 parts of Myrrhas, 35 parts of Radix Et Rhizoma Rhei, 35 parts of Rhizoma Coptidis, 25 parts in Radix Glycyrrhizae.
6. the Chinese patent medicine that a kind of treatment according to claim 1 is had blood in stool, its raw material weight constituent is: 78 parts of the Fructuss Sophorae, 68 parts in Radix Rubiae, 72 parts of Radix Notoginseng, 38 parts of Sanguis Draxonis, 52 parts of Myrrhas, 28 parts of Radix Et Rhizoma Rhei, 28 parts of Rhizoma Coptidis, 18 parts in Radix Glycyrrhizae.
7. the preparation method of the treatment Chinese patent medicine of having blood in stool is characterized in that step is as follows:
The first step, 70～90 parts of Fructuss Sophorae, 65～80 portions of Radix Rubiaes, 20～40 parts of Radix Et Rhizoma Rhei, 20～35 portions of Rhizoma Coptidis, 10～30 portions of Radix Glycyrrhizaes put together add 3～8 times of amounts of drug weight 70～80% ethanol with 75-85 ℃ of reflux 1～3 hour, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby; In second step, the water that the medicinal residues in the step 1 is added 8～12 times of amounts of drug weight decocted 1～3 hour with 90～100 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use; The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,60～80 ℃ are condensed into relative density and are determined as 1.35～1.38 thick paste at 60 ℃, 60～80 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby; The 4th step, 65～85 portions of Radix Notoginseng, 30～50 parts of Sanguis Draxonis, 45～65 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby; The 5th step; with the standby fine powder mix homogeneously of the 3rd step with the 4th step; add 70～80% ethanol that account for mixed powder weight 15～20%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 60～80 ℃ in hothouse was dried by the fire 1～2 hour; cross 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
8. the preparation method of the Chinese patent medicine that a kind of treatment according to claim 7 is had blood in stool, it is characterized in that, step is as follows: the first step, 75～85 parts of Fructuss Sophorae, 65～75 portions of Radix Rubiaes, 25～35 parts of Radix Et Rhizoma Rhei, 25～35 portions of Rhizoma Coptidis, 15～25 portions of Radix Glycyrrhizaes put together add 3～8 times of amounts of drug weight 70～80% ethanol with 75-85 ℃ of reflux 1～3 hour, pour out extracting solution, reflux for the second time with the same terms again, pour out extracting solution, extracted twice liquid is merged, 200 mesh sieves filter, filtrate recycling ethanol, clear paste is standby; In second step, the water that the medicinal residues in the step 1 is added 8～12 times of amounts of drug weight decocted 1～3 hour with 90～100 ℃, poured out decoction liquor, decocted for the second time with the same terms again, poured out decoction liquor, merged the secondary decoction liquor, and 200 mesh sieves filter, filtrate for later use; The 3rd step, the clear paste in the step 1 is mixed with the filtrate in the step 2,60～80 ℃ are condensed into relative density and are determined as 1.35～1.38 thick paste at 60 ℃, 60～80 ℃ of dryings, pulverizing, mistake 80 mesh sieves, mix homogeneously, fine powder is standby; The 4th step, 70～80 portions of Radix Notoginseng, 35～45 parts of Sanguis Draxonis, 50～60 parts of Myrrhas are mixed pulverizing, cross 80 mesh sieves, fine powder is standby; The 5th step; with the standby fine powder mix homogeneously of the 3rd step with the 4th step; add 70～80% ethanol that account for mixed powder weight 15～20%; make soft material, granulate with 20 eye mesh screens in granulator, the temperature with 60～80 ℃ in hothouse was dried by the fire 1～2 hour; cross 20 mesh sieve granulate; mix homogeneously is filled to capsule, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100243661A CN101703648B (en) | 2009-10-16 | 2009-10-16 | Chinese patent medicament for treating hematochezia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100243661A CN101703648B (en) | 2009-10-16 | 2009-10-16 | Chinese patent medicament for treating hematochezia and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101703648A CN101703648A (en) | 2010-05-12 |
| CN101703648B true CN101703648B (en) | 2011-05-25 |
Family
ID=42373945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100243661A Active CN101703648B (en) | 2009-10-16 | 2009-10-16 | Chinese patent medicament for treating hematochezia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101703648B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920120B (en) * | 2014-04-17 | 2017-06-20 | 烟台海研制药有限公司 | Treat the Chinese medicine composition of mink bloody stool |
| CN107582899B (en) * | 2017-10-21 | 2021-01-15 | 内蒙古民族大学附属医院 | Mongolian medicine for clearing heat and stopping bleeding and its preparing process |
-
2009
- 2009-10-16 CN CN2009100243661A patent/CN101703648B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101703648A (en) | 2010-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101797301B (en) | Medicine for preventing and curing middle and old aged constipation | |
| CN101249235B (en) | Chinese medicine for curing esophagus cancer and method of preparing the same | |
| CN105920514A (en) | Traditional Chinese medicinal composition for treating metabolic syndrome | |
| CN104162094A (en) | Traditional Chinese medicine composition for treating obese polycystic ovary syndrome, and medicinal preparation thereof | |
| CN101703648B (en) | Chinese patent medicament for treating hematochezia and preparation method thereof | |
| CN101757309B (en) | Medicament for treating uterine bleeding and preparation process thereof | |
| CN105325714A (en) | Compound feed for cows and preparation method thereof | |
| CN104324134B (en) | One kind improves microcirculatory Chinese medicine composition and preparation method thereof | |
| CN104225016B (en) | A kind of pharmaceutical composition treating due to weakness of spleen and stomach chronic atrophic gastritis | |
| CN100509043C (en) | Chinese medicine composition for eliminating drug addication | |
| CN105920186A (en) | Traditional Chinese medicine for treating haemorrhoids and preparation method thereof | |
| CN101698037B (en) | Medicine for treating uterine bleeding and preparation process thereof | |
| CN106214828A (en) | A kind of Chinese medicine of passage, nourishing blood and preparation method thereof | |
| CN104800675A (en) | Medicament for treating active ulcerative colitis | |
| CN105232854A (en) | Traditional Chinese medicine pill treating empirical constipation | |
| CN105031568A (en) | Postpartum health food and preparation method thereof | |
| CN1261156C (en) | Medicine for treating chronic gastroenteritis and colitis | |
| CN100364516C (en) | Dan e Fukang preparation and preparing method | |
| CN102302639B (en) | Traditional Chinese medicine composition for treating retention of urine | |
| CN104758708A (en) | Medicine for treating diarrhea | |
| CN106389702A (en) | Traditional Chinese medicine for recovering symptoms of gynecological and obstetric surgery and preparation method of traditional Chinese medicine | |
| CN105381364A (en) | Traditional Chinese medicine for treating chronic colitis and preparation method thereof | |
| CN105031017B (en) | A kind of nursing drug of therapeutic agent post-abortion bleeding and preparation method thereof | |
| CN101757285B (en) | Gastrointestinal disease-treating traditional Chinese medicine composition containing costustoot and preparation method thereof | |
| CN104645191A (en) | Traditional Chinese medicine composition for treating chronic ulcerative colitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: High tech Zone Zhang Bayi Road 710065 Shaanxi city of Xi'an province No. 1 Huixin IBC-B block 11 layer Patentee after: Xian Qianhe Pharmaceutical Co., Ltd. Address before: 710075 science and technology road, hi tech Industrial Development Zone, Shaanxi, Xi'an Patentee before: Xian Qianhe Pharmaceutical Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: High tech Zone Zhang Bayi Road 710065 Shaanxi city of Xi'an province No. 1 Huixin IBC-B block 11 layer Patentee after: Xi'an Millennium pharmaceutical Limited by Share Ltd Address before: High tech Zone Zhang Bayi Road 710065 Shaanxi city of Xi'an province No. 1 Huixin IBC-B block 11 layer Patentee before: Xian Qianhe Pharmaceutical Co., Ltd. |