CN1899558A - Medicine composition for treating stomach diseases and preparation method and application thereof - Google Patents
Medicine composition for treating stomach diseases and preparation method and application thereof Download PDFInfo
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- CN1899558A CN1899558A CNA2006100213944A CN200610021394A CN1899558A CN 1899558 A CN1899558 A CN 1899558A CN A2006100213944 A CNA2006100213944 A CN A2006100213944A CN 200610021394 A CN200610021394 A CN 200610021394A CN 1899558 A CN1899558 A CN 1899558A
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Abstract
The invention provides a pharmaceutical composition for treating gastropathy, which is a medicament prepared by taking crude drugs or extracts of radix linderae, rhizoma bletillae, rhizoma corydalis, round cardamon seed, patchouli, immature bitter orange, magnolia officinalis, bletilla striata, cuttle bone, dandelion, rhubarb, cinnamon, galangal and sandalwood as active ingredients and adding belladonna and pharmaceutically acceptable auxiliary materials or auxiliary ingredients. The preparation method is simple, and the prepared medicament has the advantages of quick response, short treatment course, good curative effect and difficult recurrence, and provides a new choice for clinical treatment of gastropathy.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of gastropathy, specifically, it is to be the medicament that primary raw material is prepared from the Chinese crude drug, belongs to drug world.
Background technology
So-called gastropathy is actually the general designation of many diseases, and they have similar symptom, as upper abdomen gastral cavilty portion discomfort, pain, after meal glutted, heating installation, return acid, even feel sick, vomiting or the like.Common clinically gastropathy has the innocent and malignant tumour of acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastroduodenal complex ulcer, stomach, the gastremia that also has prolapse of gastric mucosa, gastric mucosa abscission to cause is hemorrhage, acute gastric dilatation, pyloric obstruction etc., even diseases such as melena, constipation are also reduced gastropathy.
The main treatment means of gastropathy is based on " taking good care of ", " treatment " at present.
Western medicine gastropathy is based on " antacid, protection mucosa and anti-helicobacter pylori ", but side effect is obvious, but can only its side effect of gastric acid inhibitory can cause impotence and sexual disorder as first cyanogen rice croak; Bismuth aluminate compound (compound bismuth aluminate tablets) also is a kind of sour medicine that presses down, but the effect limitation can not suppress helicobacter pylori; Omeprazole can only press down acid, pain relieving still can not suppress helicobacter pylori, and price is higher.
The traditional Chinese medical science claims that gastropathy is that " gastric abscess " or " stomachache due to hyperactive liver-QI attacking the stomach " are commonly called as and are " peratodynia " or " motive pain ", the Chinese patent medicine of treatment gastropathy has XIANGSHA YANGWEI WAN, adds flavor Zuojin Wan, Aucklandiae and Amomi stomach-calming granule, WENWEISHU JIAONANG, yangweishu capsules, qizhi weitong granules (electuary), WEIDE peace sheet, Liuwei Anxiao are loose, WEISU CHONGJI etc., but these Chinese patent medicines can not be treated symptoms all in the gastropathy, and when the gastropathy acute attack effective disease controlling, be mainly used in daily conditioning and recover.
Still there is not at present a kind of medicine that can treat the various stomach symptom.
Summary of the invention
Technical problem to be solved by this invention provides a kind of pharmaceutical composition for the treatment of gastropathy.
The present composition is to contain the medicament that is prepared from following materials of weight proportions: 0.5～1 part of WUJINGEN, 5～10 parts of wooly datchmanspipe roots, 3～5 parts of Rhizoma Corydalis, 20～50 parts of Herba Taraxacis, 0.6～1 part of Cortex Cinnamomi.
Above-mentioned five tastes medicine anti inflammatory blood quickening, separate the spasm pain relieving, be monarch drug.Wherein, WUJINGEN is the root of aristolochiaceae plant black wool Herba Asari (beautiful Herba Asari) Asarum pulchellum Hemsl., has the effect of anti-inflammatory analgetic, and the effect of healing is arranged for gastric ulcer; Wooly datchmanspipe root is the root of aristolochiaceae plant Aristolochia mollissima Aristolochia mollissimaHance, has the cold syndrome of the stomach of dispelling, analgesic effect; The effect of Rhizoma Corydalis promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling; Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, can hemostasis, pain relieving, preventing or arresting vomiting, elimination flatulence; Cortex Cinnamomi energy let the fire back to its origin, warming middle-JIAO to dispel cold can be treated the stomachache of Deficiency and coldness of spleen and stomach and be suffered from abdominal pain.
Further, it also contains the following weight proportion raw material: 0.6～0.8 part of roud cardamon seed, 2.5～10 parts of Herba Pogostemonis, 2.5～6 parts of Fructus Aurantii Immaturuss, 2.5～5 parts of Cortex Magnoliae Officinalis, 0.8～5 part in Lignum Santali Albi.
These five tastes that add have relieving distension by promoting circulation of QI, all stagnant effects of the gastrointestinal that disappears, and are ministerial drug.Wherein, roud cardamon seed removing dampness by means of aromatics, warming middle-JIAO to arrest vomiting, promoting qi circulation, resolving food retention; Herba Pogostemonis removing dampness by means of aromatics and middle preventing or arresting vomiting, the pathogenic factor in the exterior that looses, Herba Pogostemonis can not substitute with herba agastachis rugosae because of containing peculiar volatile ingredient in addition, influences the synergism between drug effect and the medicine; Fructus Aurantii Immaturus has dispelling the stagnated QI removing food stagnancy, therapeutic method to keep the adverse QI flowing downwards relieving constipation, effect that circulation of qi promoting power is strong; Cortex Magnoliae Officinalis circulation of qi promoting removing dampness intestinal stasis relieving, can treat diseases such as the spleen and stomach being stranded by dampness, abdominal distention, constipation; The Lignum Santali Albi promoting the circulation of QI to relieve pain.
Further, it also contains the following weight proportion raw material: 0.3～0.8 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.1～2 part of Os Sepiae, 0.2～1 part of Radix Et Rhizoma Rhei, 2.5～5 parts of Rhizoma Alpiniae Officinarums, 0.01～0.015 part of Semen daturae Belladonna.
The Pseudobulbus Bletillae (Rhizoma Bletillae) of adding on the basis of original ten herbal medicines, Os Sepiae, Semen daturae Belladonna three herbal medicines have the effect of antacid, hemostasis, detumescence, repairing ulcer, are adjuvant drug; The Radix Et Rhizoma Rhei (being commonly called as Radix Et Rhizoma Rhei), the Rhizoma Alpiniae Officinarum that add can be cleansed gastrointestinal excess-heat, relieving constipation cold expelling, preventing or arresting vomiting, are messenger drug.Wherein, Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation; But Os Sepiae antacid, hemostasis; Radix Et Rhizoma Rhei purging heat to relax the bowels, blood circulation promoting and blood stasis dispelling, to cleanse the intestines and stomach excess-heat stagnant; Rhizoma Alpiniae Officinarum can loose cold, the treatment epigastric pain of taste, preventing or arresting vomiting; Semen daturae Belladonna has auxiliary analgesic effect, and the Semen daturae in the pharmaceutical composition of the present invention is the commercial goods Semen daturae tablet, and every contains Semen daturae extractum 10mg, and weight proportion is in the Semen daturae extractum content in the Semen daturae tablet.
The present invention treats the pharmaceutical composition of gastropathy, is the medicament that is prepared from by the following weight proportion raw material:
0.5～1 part of WUJINGEN, 5～10 parts of wooly datchmanspipe roots, 3～5 parts of Rhizoma Corydalis, 20～50 parts of Herba Taraxacis, 0.6～1 part of Cortex Cinnamomi, 0.6～0.8 part of roud cardamon seed, 2.5～10 parts of Herba Pogostemonis, 2.5～6 parts of Fructus Aurantii Immaturuss, 2.5～5 parts of Cortex Magnoliae Officinalis, 0.8～5 part in Lignum Santali Albi, 0.3～0.8 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.1～2 part of Os Sepiae, 0.2～1 part of Radix Et Rhizoma Rhei, 2.5～5 parts of Rhizoma Alpiniae Officinarums, 0.01～0.015 part of Semen daturae Belladonna.
Further, it is the medicament that is prepared from by the following weight proportion raw material:
0.5 part of WUJINGEN, 5 parts of wooly datchmanspipe roots, 3 parts of Rhizoma Corydalis, 20 parts of Herba Taraxacis, 0.6 part of Cortex Cinnamomi, 0.6 part of roud cardamon seed, 2.5 parts of Herba Pogostemonis, 2.5 parts of Fructus Aurantii Immaturuss, 2.5 parts of Cortex Magnoliae Officinalis, 0.8 part in Lignum Santali Albi, 0.3 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.3 part of Os Sepiae, 0.2 part of Radix Et Rhizoma Rhei, 2.5 parts of Rhizoma Alpiniae Officinarums, 0.015 part of Semen daturae Belladonna.
The pharmaceutical composition that the present invention treats gastropathy is that containing with WUJINGEN, wooly datchmanspipe root, Rhizoma Corydalis, roud cardamon seed, Herba Pogostemonis, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae, Herba Taraxaci, Radix Et Rhizoma Rhei, Cortex Cinnamomi, Rhizoma Alpiniae Officinarum, Lignum Santali Albi crude drug or extract is active component, adds the medicament that Semen daturae and acceptable accessories or complementary composition are prepared from.
Wherein, described medicament is regular dosage forms such as powder, granule, capsule, tablet, oral liquid or mixture.
The present invention also provides the method for this pharmaceutical composition, and it comprises the steps:
A, take by weighing raw material by weight ratio: 0.5～1 part of WUJINGEN, 5～10 parts of wooly datchmanspipe roots, 3～5 parts of Rhizoma Corydalis, 20～50 parts of Herba Taraxacis, 0.6～1 part of Cortex Cinnamomi, 0.6～0.8 part of roud cardamon seed, 2.5～10 parts of Herba Pogostemonis, 2.5～6 parts of Fructus Aurantii Immaturuss, 2.5～5 parts of Cortex Magnoliae Officinalis, 0.8～5 part in Lignum Santali Albi, 0.3～0.8 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.1～2 part of Os Sepiae, 0.2～1 part of Radix Et Rhizoma Rhei, 2.5～5 parts of Rhizoma Alpiniae Officinarums, 0.01～0.015 part of Semen daturae Belladonna;
B, get the described raw material pulverizing powdered of step a, powder size is coarse powder, middle powder, fine powder, fine powder, impalpable powder, makes powder, or powder is packed in the softgel shell, makes capsule; Or
C, can also get the described raw material WUJINGEN of step a, roud cardamon seed, Herba Pogostemonis, Cortex Cinnamomi, Lignum Santali Albi, Rhizoma Alpiniae Officinarum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Magnoliae Officinalis distillating extracting oil, preserve the water extract, medicinal residues are standby;
D, get wooly datchmanspipe root, Rhizoma Corydalis, Herba Taraxaci, Fructus Aurantii Immaturus, Os Sepiae, Radix Et Rhizoma Rhei, add and remain medicinal residues after carrying volatile oil, decoct with water, filter filtrate, add aromatics medicine gained water extract, concentrate, drying is mixed with Semen daturae;
E, get said mixture, add the medicament that step c gained volatile oil and acceptable accessories or complementary composition are prepared from.
The present invention also provides the purposes of this pharmaceutical composition in the medicine of preparation treatment gastropathy.
Wherein, described gastropathy is acute gastritis, chronic gastritis, superficial gastritis, flatulence pain, gastric ulcer, digestive tract hemorrhage, duodenal ulcer, gastroduodenal complex ulcer, and the gastremia that also has gastric mucosa abscission, gastric mucosa abscission to cause is hemorrhage, acute gastric dilatation, pyloric obstruction; Also comprise diseases such as constipation, melena.It mainly is the gastropathy disease that causes at cold syndrome of the stomach, gastric qi.
Ten five tastes material combination are used and are had vital energy regualting and blood circulation-promoting, pain relieving, hemostasis, preventing or arresting vomiting, antacid, cold expelling, antiinflammatory, heat clearing away, healing ulcer, relieving constipation, relieving distension, appetite promoting and the spleen strengthening in the prescription of the present invention.Remarkable to a gastropathy and a digestive system treatment for diseases effect.Therapeutic process instant effect (general disease played a role after the half an hour of taking medicine, and alleviated the sufferer symptom), short treating period, difficult recurrence.According to the Chinese medical theory method of treatment rule of treatment, can also on prescription raw material of the present invention basis, set out according to the clinical diagnosis actual needs, add, subtract, replace the medicine of the relevant indication of treatment, and do not break away from the medicine method of treatment rule of treatment of the present invention.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 powder of the present invention
A, take by weighing raw material: WUJINGEN 5g, wooly datchmanspipe root 50g, Rhizoma Corydalis 30g, roud cardamon seed 6g, Herba Pogostemonis 25g, Fructus Aurantii Immaturus 25g, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 25g, Pseudobulbus Bletillae (Rhizoma Bletillae) 3g, Os Sepiae 3g, Herba Taraxaci 200g, Radix Et Rhizoma Rhei 2g, Cortex Cinnamomi 6g, Rhizoma Alpiniae Officinarum 25g, Lignum Santali Albi 8g, Semen daturae Belladonna 0.15g by weight ratio;
B, get the described raw material pulverizing powdered of step a, powder size is a fine powder, makes powder.
This powder is 10 taking doses.
The preparation of embodiment 2 powders of the present invention
A, take by weighing raw material: WUJINGEN 5g, wooly datchmanspipe root 50g, Rhizoma Corydalis 30g, Herba Taraxaci 200g, Cortex Cinnamomi 6g by weight ratio;
B, get the described raw material pulverizing powdered of step a, powder size is an impalpable powder, makes powder.
This powder is 10 taking doses.
The preparation of embodiment 3 powders of the present invention
A, by weight ratio take by weighing raw material: WUJINGEN 5g, wooly datchmanspipe root 50g, Rhizoma Corydalis 30g, Herba Taraxaci 200g, Cortex Cinnamomi 6g, roud cardamon seed 6g, Herba Pogostemonis 25g, Fructus Aurantii Immaturus 25g, Cortex Magnoliae Officinalis 25g, Lignum Santali Albi 8g,
B, get the described raw material pulverizing powdered of step a, powder size is a fine powder, makes powder.
This powder is 10 taking doses.
The preparation of embodiment 4 powders of the present invention
A, take by weighing raw material: WUJINGEN 1g, wooly datchmanspipe root 10g, Rhizoma Corydalis 5g, roud cardamon seed 0.8g, Herba Pogostemonis 10g, Fructus Aurantii Immaturus 6g, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 5g, Pseudobulbus Bletillae (Rhizoma Bletillae) 0.8g, Os Sepiae 2g, Herba Taraxaci 50g, Radix Et Rhizoma Rhei 1g, Cortex Cinnamomi 1g, Rhizoma Alpiniae Officinarum 5g, Lignum Santali Albi 5g, Semen daturae Belladonna 0.015g by weight ratio;
B, get the described raw material pulverizing powdered of step a, powder size is made powder for fine powder.
This powder is 1 taking dose.
The preparation of embodiment 5 powders of the present invention
A, take by weighing raw material: WUJINGEN 15g, wooly datchmanspipe root 75g, Rhizoma Corydalis 50g, roud cardamon seed 65g, Herba Pogostemonis 75g, Fructus Aurantii Immaturus 60g, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 40g, Pseudobulbus Bletillae (Rhizoma Bletillae) 55g, Os Sepiae 15g, Herba Taraxaci 80g, Radix Et Rhizoma Rhei 10g, Cortex Cinnamomi 10g, Rhizoma Alpiniae Officinarum 40g, Lignum Santali Albi 40g, Semen daturae Belladonna 0.30g by weight ratio;
B, get the described raw material pulverizing powdered of step a, powder size is a coarse powder, makes powder.
This powder is 30 taking doses.
The preparation of embodiment 6 powders of the present invention
A, take by weighing raw material: WUJINGEN 1g, wooly datchmanspipe root 5g, Rhizoma Corydalis 5g, roud cardamon seed 0.8g, Herba Pogostemonis 10g, Fructus Aurantii Immaturus 5g, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 4g, Pseudobulbus Bletillae (Rhizoma Bletillae) 0.6g, Os Sepiae 2g, Herba Taraxaci 20g, Radix Et Rhizoma Rhei 0.8g, Cortex Cinnamomi 0.8g, Rhizoma Alpiniae Officinarum 4g, Lignum Santali Albi 3g, Semen daturae Belladonna0.015g by weight ratio;
B, get the described raw material pulverizing powdered of step a, powder size is an impalpable powder, makes powder.
This powder is 1 taking dose.
The preparation of embodiment 7 capsules of the present invention
Get embodiment 1,2,3,4,6 gained powders respectively and pack in the softgel shell, make capsule.The taking dose number of times is consistent with former embodiment.
The preparation of embodiment 8 pills of the present invention
Get the powder of embodiment 1～6 gained respectively, call in refined honey, be prepared into pill.The taking dose number of times is consistent with former embodiment.
The preparation of embodiment 9 tablets of the present invention
A, take by weighing raw material: WUJINGEN 50g, wooly datchmanspipe root 500g, Rhizoma Corydalis 300g, roud cardamon seed 60g, Herba Pogostemonis 250g, Fructus Aurantii Immaturus 200g, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 250g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Os Sepiae 30g, Herba Taraxaci 2000g, Radix Et Rhizoma Rhei 20g, Cortex Cinnamomi 60g, Rhizoma Alpiniae Officinarum 250g, Lignum Santali Albi 80g, Semen daturae Belladonna 1.5g by weight ratio;
B, get raw material WUJINGEN, roud cardamon seed, Herba Pogostemonis, Cortex Cinnamomi, Lignum Santali Albi, Rhizoma Alpiniae Officinarum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Magnoliae Officinalis described in the step a and carry volatile oil, preserve the water extract, medicinal residues are standby;
C, get step b surplus stock (remove Semen daturae), add and remain medicinal residues after carrying volatile oil, decoct with water, filter filtrate, add step c gained water extract, concentrate, drying is mixed with Semen daturae;
D, get step c mixture, add starch slurry and make soft material, granulate, granulate adds an amount of Pulvis Talci and magnesium stearate mix homogeneously, and tabletting promptly.
This tablet is 100 taking doses.
The preparation of embodiment 10 capsules of the present invention
A, take by weighing raw material: WUJINGEN 50g, wooly datchmanspipe root 500g, Rhizoma Corydalis 300g, roud cardamon seed 60g, Herba Pogostemonis 250g, Fructus Aurantii Immaturus 250g, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China 250g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Os Sepiae 30g, Herba Taraxaci 2000g, Radix Et Rhizoma Rhei 20g, Cortex Cinnamomi 60g, Rhizoma Alpiniae Officinarum 250g, Lignum Santali Albi 80g, Semen daturae Belladonna 1.5g by weight ratio;
B, get raw material WUJINGEN, roud cardamon seed, Herba Pogostemonis, Cortex Cinnamomi, Lignum Santali Albi, Rhizoma Alpiniae Officinarum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Magnoliae Officinalis described in the step a and carry volatile oil, preserve the water extract, medicinal residues are standby;
C, get step b surplus stock (remove Semen daturae), add and remain medicinal residues after carrying volatile oil, decoct with water, filter filtrate, add step c gained water extract, concentrate, drying is mixed with Semen daturae, pulverizing is encapsulated.
This capsule is 100 taking doses.
Below prove the beneficial effect of medicine of the present invention by case statistics and individual case.
Added up for 1 1998-2006 service time of clinical drug of the present invention, treat about 600 examples of total case, the patient suffers from stomach discomfort such as flatulence pain, gastritis, and diseases such as stomach, duodenal ulcer, according to the clinical case statistics of placing on record, therapeutic effect sees Table 1:
Use medicine during this time, with prescription 1 (WUJINGEN 0.5～1g, wooly datchmanspipe root 5～10g, Rhizoma Corydalis 3～5g, Herba Taraxaci 20～50g, Cortex Cinnamomi 0.6～1g, roud cardamon seed 0.6～0.8g, Herba Pogostemonis 2.5～10g, Fructus Aurantii Immaturus 2.5～6g, Cortex Magnoliae Officinalis 2.5～5g, Lignum Santali Albi 0.8～5g, the Pseudobulbus Bletillae (Rhizoma Bletillae) 0.3～0.8g, Os Sepiae 0.1～2g, Radix Et Rhizoma Rhei 0.2～1g, Rhizoma Alpiniae Officinarum 2.5～5g, Semen daturae Belladonna 0.01～0.015g, this dosage is a dose) be the basis, add according to clinical needs and to simplify the sanction prescription; Wherein preferred prescription 2 (WUJINGEN 0.5g, wooly datchmanspipe root 5g, Rhizoma Corydalis 3g, Herba Taraxaci 20g, Cortex Cinnamomi 0.6g, roud cardamon seed 0.6g, Herba Pogostemonis 2.5g, Fructus Aurantii Immaturus 2.5g, Cortex Magnoliae Officinalis 2.5g, Lignum Santali Albi 0.8g, Pseudobulbus Bletillae (Rhizoma Bletillae) 0.3g, Os Sepiae 0.3g, Radix Et Rhizoma Rhei 0.2g, Rhizoma Alpiniae Officinarum 2.5g, Semen daturae Belladonna 0.015g, this dosage are a dose) is made powder or capsule.
The concrete disease statistics of table 1 the present invention
| Disease | The example number | Recovery from illness | Take a turn for the better | Invalid | Effective percentage |
| Acute gastritis chronic gastritis, gastric ulcer duodenal ulcer gasteremphraxis stomachache gastrorrhagia indigestion | 4 115 10 5 130 112 18 206 | 2 113 9 4 127 111 16 203 | 1 2 1 1 3 1 2 3 | 1 | 75％ 100％ 100％ 100％ 100％ 100％ 100％ 100％ |
Efficient calculating is to comprise that (recovery from illness refers to rehabilitation to two kinds of situations of recovery from illness and improvement, the disease complete obiteration in the above table; Improvement refer to disease alleviate, but not complete obiteration).Show curable substance various stomach symptom of the present invention, and therapeutic effect is remarkable, effective percentage mostly is 100%.
Add up 2 clinical drug typical case records of the present invention
1,31 years old flatulence pain of patient Li Gang man, melena, in February, 2003 certain hospital control seek medical advice fail to respond to any medical treatment after, take medicine of the present invention (embodiment 10 preparations) in June, 2003, day clothes 3 times treats after three months, recurrence was not seen in state of an illness elimination in 2 years.
2, the old dish woman of a specified duration of patient flatulence, belch occur 72 years old in March, 2004, takes medicine of the present invention (embodiment 10 preparations), and day clothes 3 times were treated after 7 days, and the state of an illness is eliminated and do not seen recurrence half a year.
3, patient Wang Qinan 58 years old flatulence pain, melena sought medical advice in August, 2002, takes medicine of the present invention (embodiment 10 preparations), and day clothes 3 times were treated after six months, and the state of an illness is eliminated and do not seen recurrence in 3 years.
4, patient Peng Binnan flatulence 25 years old in January, 2005, through medicine of the present invention (embodiment 1 preparation) treatment, day clothes 3 times were treated 2 days, and the state of an illness is eliminated and was not seen recurrence in five months.
5, patient's literary composition holt woman seeks medical advice 22 years old in March, 2005, disease performance flatulence pain, and through medicine of the present invention (embodiment 1 preparation) treatment, day clothes 3 times were treated 7 days, and the state of an illness is eliminated and is not seen recurrence.
According to inventor's clinical experience, in the regular dosage form of pharmaceutical composition of the present invention, curative effect is clear and definite, and the various disease conditions in the treatment gastropathy is all imitated soon, short treating period, and good effect is difficult for recurrence.Best in the dosage form with the capsule effect, for clinical treatment gastropathy provides a kind of new selection.
Claims (10)
1, a kind of pharmaceutical composition for the treatment of gastropathy is characterized in that: it is to contain the medicament that is prepared from following materials of weight proportions:
0.5～1 part of WUJINGEN, 5～10 parts of wooly datchmanspipe roots, 3～5 parts of Rhizoma Corydalis, 20～50 parts of Herba Taraxacis, 0.6～1 part of Cortex Cinnamomi.
2, the pharmaceutical composition of treatment gastropathy according to claim 1 is characterized in that: it also contains the following weight proportion raw material:
0.6～0.8 part of roud cardamon seed, 2.5～10 parts of Herba Pogostemonis, 2.5～6 parts of Fructus Aurantii Immaturuss, 2.5～5 parts of Cortex Magnoliae Officinalis, 0.8～5 part in Lignum Santali Albi.
3, the pharmaceutical composition of treatment gastropathy according to claim 2 is characterized in that: it also contains the following weight proportion raw material:
0.3～0.8 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.1～2 part of Os Sepiae, 0.2～1 part of Radix Et Rhizoma Rhei, 2.5～5 parts of Rhizoma Alpiniae Officinarums, 0.01～0.015 part of Semen daturae Belladonna.
4, the pharmaceutical composition of treatment gastropathy according to claim 3 is characterized in that: it is the medicament that is prepared from by the following weight proportion raw material:
0.5～1 part of WUJINGEN, 5～10 parts of wooly datchmanspipe roots, 3～5 parts of Rhizoma Corydalis, 20～50 parts of Herba Taraxacis, 0.6～1 part of Cortex Cinnamomi, 0.6～0.8 part of roud cardamon seed, 2.5～10 parts of Herba Pogostemonis, 2.5～6 parts of Fructus Aurantii Immaturuss, 2.5～5 parts of Cortex Magnoliae Officinalis, 0.8～5 part in Lignum Santali Albi, 0.3～0.8 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.1～2 part of Os Sepiae, 0.2～1 part of Radix Et Rhizoma Rhei, 2.5～5 parts of Rhizoma Alpiniae Officinarums, 0.01～0.015 part of Semen daturae Belladonna.
5, the pharmaceutical composition of treatment gastropathy according to claim 4 is characterized in that: it is the medicament that is prepared from by the following weight proportion raw material:
0.5 part of WUJINGEN, 5 parts of wooly datchmanspipe roots, 3 parts of Rhizoma Corydalis, 20 parts of Herba Taraxacis, 0.6 part of Cortex Cinnamomi, 0.6 part of roud cardamon seed, 2.5 parts of Herba Pogostemonis, 2.5 parts of Fructus Aurantii Immaturuss, 2.5 parts of Cortex Magnoliae Officinalis, 0.8 part in Lignum Santali Albi, 0.3 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.3 part of Os Sepiae, 0.2 part of Radix Et Rhizoma Rhei, 2.5 parts of Rhizoma Alpiniae Officinarums, 0.015 part of Semen daturae Belladonna.
6, according to the pharmaceutical composition of each described treatment gastropathy of claim 3～5, it is characterized in that: it is that containing with WUJINGEN, wooly datchmanspipe root, Rhizoma Corydalis, roud cardamon seed, Herba Pogostemonis, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Os Sepiae, Herba Taraxaci, Radix Et Rhizoma Rhei, Cortex Cinnamomi, Rhizoma Alpiniae Officinarum, Lignum Santali Albi crude drug, processed product or extract is active component, adds the medicament that Semen daturae Belladonna and acceptable accessories or complementary composition are prepared from.
7, according to the pharmaceutical composition of claim 1 or 2 or 6 each described treatment gastropathy, it is characterized in that: described medicament is powder, granule, capsule, tablet, oral liquid or mixture.
8, a kind of method for preparing the pharmaceutical composition of each described treatment gastropathy of claim 3～5, it comprises the steps:
A, take by weighing raw material by weight ratio: 0.5～1 part of WUJINGEN, 5～10 parts of wooly datchmanspipe roots, 3～5 parts of Rhizoma Corydalis, 20～50 parts of Herba Taraxacis, 0.6～1 part of Cortex Cinnamomi, 0.6～0.8 part of roud cardamon seed, 2.5～10 parts of Herba Pogostemonis, 2.5～6 parts of Fructus Aurantii Immaturuss, 2.5～5 parts of Cortex Magnoliae Officinalis, 0.8～5 part in Lignum Santali Albi, 0.3～0.8 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 0.1～2 part of Os Sepiae, 0.2～1 part of Radix Et Rhizoma Rhei, 2.5～5 parts of Rhizoma Alpiniae Officinarums, 0.01～0.015 part of Semen daturae Belladonna;
B, get the described raw material pulverizing powdered of step a, powder size is coarse powder, middle powder, fine powder, fine powder, impalpable powder, makes powder, or powder is packed in the softgel shell, makes capsule; Or
C, get raw material WUJINGEN described in the step a, roud cardamon seed, Herba Pogostemonis, Cortex Cinnamomi, Lignum Santali Albi, Rhizoma Alpiniae Officinarum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Magnoliae Officinalis distillating extracting oil, preserve the water extract, medicinal residues are standby;
D, get wooly datchmanspipe root, Rhizoma Corydalis, Herba Taraxaci, Fructus Aurantii Immaturus, Os Sepiae, Radix Et Rhizoma Rhei, add and remain medicinal residues after carrying volatile oil, decoct with water, filter filtrate, add step c gained water extract, concentrate, drying is mixed with Semen daturae;
E, get the steps d mixture, add the medicament that step c gained volatile oil and acceptable accessories or complementary composition are prepared from.
9, the purposes of the described pharmaceutical composition of claim 1 in the medicine of preparation treatment gastropathy.
10, purposes according to claim 9 is characterized in that: described gastropathy is cold syndrome of the stomach, gastric qi, flatulence pain, gastritis, digestive tract hemorrhage, gastric ulcer, duodenal ulcer or constipation.
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| CNB2006100213944A CN100471519C (en) | 2006-07-14 | 2006-07-14 | Medicine composition for treating stomach diseases and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688433A (en) * | 2012-06-14 | 2012-09-26 | 李良 | Galangal Chinese medicinal decoction for treating stomachache and preparation method thereof |
| CN102940855A (en) * | 2012-12-07 | 2013-02-27 | 青岛市市立医院 | Pharmaceutical composition for treating gastropathy and preparation method of pharmaceutically composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095381C (en) * | 1999-12-29 | 2002-12-04 | 苗少伯 | Method for preparing medicine for curing gastropathy |
| CN1201784C (en) * | 2002-12-11 | 2005-05-18 | 李哲 | Oral liquid medicine for treating stomach-pain, and its prepn. method |
| CN1182865C (en) * | 2003-01-20 | 2005-01-05 | 叶彬 | Medicine for treating discomforts in insteines and stomach |
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2006
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688433A (en) * | 2012-06-14 | 2012-09-26 | 李良 | Galangal Chinese medicinal decoction for treating stomachache and preparation method thereof |
| CN102688433B (en) * | 2012-06-14 | 2013-10-09 | 李良 | Galangal Chinese medicinal decoction for treating stomachache and preparation method thereof |
| CN102940855A (en) * | 2012-12-07 | 2013-02-27 | 青岛市市立医院 | Pharmaceutical composition for treating gastropathy and preparation method of pharmaceutically composition |
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