CN1140071A - Anticancer drug and preparing method thereof - Google Patents
Anticancer drug and preparing method thereof Download PDFInfo
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- CN1140071A CN1140071A CN95108065A CN95108065A CN1140071A CN 1140071 A CN1140071 A CN 1140071A CN 95108065 A CN95108065 A CN 95108065A CN 95108065 A CN95108065 A CN 95108065A CN 1140071 A CN1140071 A CN 1140071A
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- rhizoma
- radix
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- borneolum syntheticum
- calculus bovis
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Abstract
An anticancer Chinese patent medicine is prepared from 29 Chinese-medicinal materials such as notoginseng, pilose asiabell root, astragalus root, white atractylodes rhizome, liquorice root, etc. through crushing, sieving, decoction, concentration, drying, sterilization, mixing and tabletting or filling in capsules, and features low toxic by-effect and distinct curative effect.
Description
The present invention relates to a kind of anticancer medicine, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Cancer is a serious harm human body health, threatens human life's commonly encountered diseases, frequently-occurring disease.The World Health Organization's statistics in 1970, in the whole world 4,000,000,000 populations, have about five hundred ten thousand because of malignant tumor death person every year.This tissue statistics in 1981 shows that about 37,000,000 cancer patients are arranged at present in the world; The new patient of developing country's annual increase by 5,000,000 cancers; Annual increase by the 3000000 new cancer patients of developed country.Cancer is considered to cause in the world at present three big one of the main reasons of people's death, therefore seeks new cancer therapy drug, has become the emphasis of current medical science and life science.
At present, generally use the treatment method for cancer to be chemotherapy and radiation both at home and abroad, and hemopoietic system, the immunologic function of chemotherapy, radiotherapy meeting major injury human body, and side effect is many, toxic reaction.
The object of the present invention is to provide a kind of determined curative effect, easy to use, safety non-toxic can effectively be treated Chinese patent medicine of cancer and preparation method thereof.
Medicine of the present invention is made (unit: gram) by following component
Radix Notoginseng 255-345 Radix Codonopsis 170-230 Radix Astragali 170-230
Rhizoma Atractylodis Macrocephalae 127.5-172.5 Radix Glycyrrhizae 255-345 Rhizoma Polygonati 170-230
Radix Ophiopogonis 170-230 Rhizoma Polygonati Odorati 170-230 Radix Aconiti Preparata 170-230
Rhizoma Paridis 255-345 Herba Portulacae Grandiflorae 170-230 Herba Violae 170-230
Radix Scutellariae 170-230 Rhizoma Smilacis Glabrae 170-230 Spica Prunellae 170-230
Rhizoma Polygoni Cuspidati 170-230 Pseudobulbus cremastrae seu pleiones 255-345 Radix Bupleuri 170-230
Sanguis Draxonis 42.5-57.5 Semen Vaccariae 85-115 Rhizoma Curcumae Longae 85-115
Flos Inulae 170-230 Lignum Dalbergiae Odoriferae 42.5-57.5 Haematitum 85-115
Rhizoma Corydalis 255-345 Rhizoma Phragmitis 255-345 Radix Et Rhizoma Rhei 85-115
Semen Pharbitidis 42.5-57.5 Borneolum Syntheticum 51-69 Calculus Bovis 2.55-3.45
Technical process and the condition of above-mentioned each component being made medicine of the present invention are:
1. refine
1. differentiate and select Chinese crude drug;
2. the Chinese crude drug raw material is ground into fine powder and cross sieve No. nine;
3. Calculus Bovis, Borneolum Syntheticum, the fine ground mistake of Haematitum difference are sieved for No. nine;
4. except that Borneolum Syntheticum and Calculus Bovis directly were used as medicine after pulverizing sterilization with crude drug in whole, other 28 flavor medicines all will be concentrated and decoct three times, medicinal liquid after filtration, concentrate, precipitate with ethanol.Medicinal liquid behind the precipitate with ethanol continues to be condensed into extractum, and oven dry stone roller powder is stand-by.
2. preparation
1. extractum is added appropriate amount of starch and dextrin and mix, with distilled oil and the abundant mixed pelletization of ethanol, oven dry in right amount;
2. add behind Calculus Bovis and Borneolum Syntheticum and the lubricant granulate through pulverizing sterilization in the granule of drying or tabletting, or divide encapsulatedly, put in storage quality inspection packing back.
Instructions of taking of the present invention:
Take every day three times, take 8 at every turn, boiled water takes after meal.Look state of an illness weight and patient's gastro-intestinal digestion situation dose can increase and decrease in 6-12 grain scope.
Embodiment 1:
The optimum weight proportioning of medicine of the present invention is: (unit: gram)
Radix Notoginseng 300 Radix Codonopsis 200 Radixs Astragali 200
The Rhizoma Atractylodis Macrocephalae 150 Radix Glycyrrhizaes 300 Rhizoma Polygonatis 200
Radix Ophiopogonis 200 Rhizoma Polygonati Odorati, 200 Radix Aconiti Preparatas 200
Rhizoma Paridis 300 Herba Portulacae Grandifloraes 200 Herba Violaes 200
Radix Scutellariae 200 Rhizoma Smilacis Glabraes 200 Spica Prunellaes 200
Rhizoma Polygoni Cuspidati 200 Pseudobulbus cremastrae seu pleiones 300 Radix Bupleuri 200
Sanguis Draxonis 50 Semen Vaccariae 100 Rhizoma Curcumae Longaes 100
Flos Inulae 200 Lignum Dalbergiae Odoriferaes 50 Haematitums 100
Rhizoma Corydalis 300 Rhizoma Phragmitiss 300 Radix Et Rhizoma Rhei 100
Semen Pharbitidis 50 Borneolum Syntheticums 60 Calculus Boviss 3
Its preparation method is:
The prescription Chinese crude drug removes Borneolum Syntheticum and Calculus Bovis is crossed sieve after crushed No. nine; and outside directly being used as medicine after the sterilization; all the other 28 medicated powder are broken; cross sieve No. nine; concentrate water to decoct three times; with the gained medical filtration, concentrate, continue to be condensed into extractum behind the precipitate with ethanol and oven dry is pulverized, add appropriate amount of starch and dextrin then and mix, with distilled oil and an amount of abundant mixed pelletization of ethanol, oven dry.Add lubricant in the granule after oven dry and through pretreated Borneolum Syntheticum and Calculus Bovis, tabletting or divide encapsulated behind the granulate.
30 flavor medicines of above weight proportion can make 1000 of 1000 in tablet or capsules.
Its using method is:
Take every day three times, take 8 at every turn, boiled water takes after meal.Look state of an illness weight and patient's gastro-intestinal digestion situation dose can increase and decrease in 6-12 grain scope.
Embodiment 2:
Take by weighing raw material by following proportioning: (unit: gram)
Radix Notoginseng 255 Radix Codonopsis 170 Radixs Astragali 170
The Rhizoma Atractylodis Macrocephalae 127.5 Radix Glycyrrhizaes 255 Rhizoma Polygonatis 170
Radix Ophiopogonis 170 Rhizoma Polygonati Odorati, 170 Radix Aconiti Preparatas 170
Rhizoma Paridis 255 Herba Portulacae Grandifloraes 170 Herba Violaes 170
Radix Scutellariae 170 Rhizoma Smilacis Glabraes 170 Spica Prunellaes 170
Rhizoma Polygoni Cuspidati 170 Pseudobulbus cremastrae seu pleiones 255 Radix Bupleuri 170
Sanguis Draxonis 42.5 Semen Vaccariae 85 Rhizoma Curcumae Longaes 85
Flos Inulae 170 Lignum Dalbergiae Odoriferaes 42.5 Haematitums 85
Rhizoma Corydalis 255 Rhizoma Phragmitiss 255 Radix Et Rhizoma Rhei 85
Semen Pharbitidis 42.5 Borneolum Syntheticums 51 Calculus Boviss 2.55
Its preparation method and using method are with embodiment 1.
Embodiment 3:
Prescription of the present invention is made up of following traditional Chinese medicines: (unit: gram)
Radix Notoginseng 345 Radix Codonopsis 230 Radixs Astragali 230
The Rhizoma Atractylodis Macrocephalae 172.5 Radix Glycyrrhizaes 345 Rhizoma Polygonatis 230
Radix Ophiopogonis 230 Rhizoma Polygonati Odorati, 230 Radix Aconiti Preparatas 230
Rhizoma Paridis 345 Herba Portulacae Grandifloraes 230 Herba Violaes 230
Radix Scutellariae 230 Rhizoma Smilacis Glabraes 250 Spica Prunellaes 230
Rhizoma Polygoni Cuspidati 230 Pseudobulbus cremastrae seu pleiones 345 Radix Bupleuri 230
Sanguis Draxonis 57.5 Semen Vaccariae 115 Rhizoma Curcumae Longaes 115
Flos Inulae 230 Lignum Dalbergiae Odoriferaes 57.5 reddish brown 115
Rhizoma Corydalis 345 Rhizoma Phragmitiss 345 Radix Et Rhizoma Rhei 115
Semen Pharbitidis 57.5 Borneolum Syntheticums 69 Calculus Boviss 3.45
Its preparation method and using method are with embodiment 1.
The present invention carries out the treatment and the clinical observation of system to the patient that 500 examples have different medical histories, the state of an illness, age, sex, and effective percentage is 96%, and cure rate is 26%.Below in conjunction with three routine medical records, the effect of Drug therapy cancer of the present invention is specified:
Medical record 1
Pueraria lobota * *, man, 66 years old.The patient is because of the recurrent cough, expectoration 3 years is surplus, increases the weight of a week, lives into The Second Affiliated Hospital of Kunming Medical School October 27 nineteen ninety, through the People's Hospital, Yunnan Province radiology department CT examination report and lung PCT diagnosis of scans conclusion: the disconnected peripheral type carcinoma of lung of the inferior lobe of right lung back of the body, to late period.The patient in nineteen ninety December began to take medicine of the present invention on the 6th, instructions of taking is: every day three times, each 8, boiled water takes after meal.
The patient adheres to taking medicine and ends on May 6th, 1991, diagnoses through Kunming General Hospital Chengdu Military Area radiology department CT examination: the disconnected pulmonary carcinoma lamellar of the bottom right lung back of the body absorbs, has not had the shaping solid tumor mass, and sick the announcement fully recovered.
Medical record 2
Old *, the woman, 24 years old, patient's stomachache, the stool front and back are many hemorrhage February, fail to respond to any medical treatment repeatedly, and pathologic finding is diagnosed as through The Second Affiliated Hospital of Kunming Medical School: the rectum neoplasm.Take medicine of the present invention, instructions of taking: every day three times, each 8, boiled water takes after meal.(be 60-180 days a course of treatment) checks to hospital after one course of treatment, and pathological examination results is: the enclosed mass complete obiteration.So far gun-ho.
Medical record 3
Poplar * *, woman, 10 years old.The patient did not move back because of fever in October, 1989, and gingiva, subcutaneous hemorrhage are lived the treatment of 60 military hospitals, Dali, be chronic leukemia after diagnosing, live the treatment of The Second Affiliated Hospital of Kunming Medical School and hospital general, the military region November nineteen ninety, through expert diagnosis, consistent conclusion is: chronic leukemia.The patient in nineteen ninety December began to take medicine of the present invention on the 4th, instructions of taking: every day three times, each 8, boiled water takes after meal.Continue to take medicine and check to hospital in March, 1991, earlier after the cloud large hospital, PLA General Hospital is worn as bone respectively, and hemogram etc. check that comprehensively all normal, disease obtains recovery from illness.
The present invention is the characteristics from theory of traditional Chinese medical science " organic conception " and " dialectical opinion is controlled ", Think that cancer is a kind of multisystem, the systemic disease of many organs, multicenter growth is for it Lesion characteristic adopts the traditional Chinese medical science to set upright reinforcing, and is clearing heat and detoxicating, promoting blood circulation and stopping pain, and the rules for the treatment of such as function of spleen and stomach regulating, On the basis, analgesic, human body is carried out multichannel and regulate, coordinate patient's vivo environment and state, Reach eventually inhibition, antagonism, the purpose of killing tumor cells. Compared with prior art, the present invention has Following advantage:
1. the present invention is pure Chinese medicinal preparation, the energy Long-term Oral, and toxic and side effect is little. Through the Yunnan medicine The product check detects, and records median lethal dose and is: 2001 ± 300mg/kg body weight.
2. Main Ingredients and Appearance of the present invention, its pharmacological function has multifunctional effect, wherein has Medicine energy adjuster vivo environment improves the patient immune function; Having of having is clearing heat and detoxicating, lives Blood and relieving pain, the function of soft heavily fortified point; What have has function of spleen and stomach regulating, an orectic function; The tool that has There is fragrance to walk to alter, the function that eliminating stagnation to stop pain etc. cooperatively interact. Multi-functional meaning is: press down and kill Develop simultaneously with reconstruction, for this multisystem of cancer, many organs, the general disease of multicenter growth Disease is paid attention to integral body, is taken into account the part, and performance is comprehensive, and effectively therapeutic action solves single medicine The indeterminable problem of thing.
3. can Effective Raise cancer patient's immunologic function.
4. can effectively alleviate the hardship that various tumours, particularly late tumor patient have an intense pain.
5. can make big improvement of symptom of cancer patient, improve a poor appetite, regain one's strength. Through right The observation of 500 routine kinds cancer patient treatment effects, be 60-180 days the course for the treatment of, all can change Kind symptom is promoted diet, and spirit is clearly better, and is efficient 96%, cures 26%. Its In to lung cancer, cholangiocarcinoma, the cancer of the uterus, leukemia then effect are better.
Claims (5)
1. an anticancer medicine is characterized in that it is the medicament of being made by the following weight proportion raw material: (unit: gram)
Radix Notoginseng 255-345 Radix Codonopsis 170-230 Radix Astragali 170-230
Rhizoma Atractylodis Macrocephalae 127.5-172.5 Radix Glycyrrhizae 255-345 Rhizoma Polygonati 170-230
Radix Ophiopogonis 170-230 Rhizoma Polygonati Odorati 170-230 Radix Aconiti Preparata 170-230
Rhizoma Paridis 255-345 Herba Portulacae Grandiflorae 170-230 Herba Violae 170-230
Radix Scutellariae 170-230 Rhizoma Smilacis Glabrae 170-230 Spica Prunellae 170-230
Rhizoma Polygoni Cuspidati 170-230 Pseudobulbus cremastrae seu pleiones 255-345 Radix Bupleuri 170-230
Sanguis Draxonis 42.5-57.5 Semen Vaccariae 85-115 Rhizoma Curcumae Longae 85-115
Flos Inulae 170-230 Lignum Dalbergiae Odoriferae 42.5-57.5 Haematitum 85-115
Rhizoma Corydalis 255-345 Rhizoma Phragmitis 255-345 Radix Et Rhizoma Rhei 85-115
Semen Pharbitidis 42.5-57.5 Borneolum Syntheticum 51-69 Calculus Bovis 2.55-3.45
2. the cancer therapy drug according to claim 1 wherein weight proportion of each raw material is: (unit: gram)
Radix Notoginseng 300 Radix Codonopsis 200 Radixs Astragali 200
The Rhizoma Atractylodis Macrocephalae 150 Radix Glycyrrhizaes 300 Rhizoma Polygonatis 200
Radix Ophiopogonis 200 Rhizoma Polygonati Odorati, 200 Radix Aconiti Preparatas 200
Rhizoma Paridis 300 Herba Portulacae Grandifloraes 200 Herba Violaes 200
Radix Scutellariae 200 Rhizoma Smilacis Glabraes 200 Spica Prunellaes 200
Rhizoma Polygoni Cuspidati 200 Pseudobulbus cremastrae seu pleiones 300 Radix Bupleuri 200
Sanguis Draxonis 50 Semen Vaccariae 100 Rhizoma Curcumae Longaes 100
Flos Inulae 200 Lignum Dalbergiae Odoriferaes 50 Haematitums 100
Rhizoma Corydalis 300 Rhizoma Phragmitiss 300 Radix Et Rhizoma Rhei 100
Semen Pharbitidis 50 Borneolum Syntheticums 60 Calculus Boviss 3
3. cancer therapy drug according to claim 1 and 2 is characterized in that said medicament is a said dosage form on any pharmaceutics.
4. cancer therapy drug according to claim 3 is characterized in that described pharmaceutical formulation is tablet or capsule.
5. the preparation method of medicine according to claim 4 is characterized in that adopting following technical process:
(1) refines
1. differentiate and select Chinese crude drug;
2. the Chinese crude drug raw material is broken into fine powder and cross sieve No. nine;
3. Calculus Bovis, Borneolum Syntheticum, the fine ground mistake of Haematitum difference are sieved for No. nine;
4. except that Borneolum Syntheticum and Calculus Bovis directly were used as medicine after pulverizing sterilization with crude drug in whole, other 28 flavor medicines all will be concentrated and decoct three times, medicinal liquid after filtration, concentrate, precipitate with ethanol, the medicinal liquid behind the precipitate with ethanol continues to be condensed into extractum, and oven dry to grind powder stand-by;
(2) preparation
1. extractum is added appropriate amount of starch and dextrin and mix, with distilled oil and the abundant mixed pelletization of ethanol, oven dry in right amount;
2. add behind Calculus Bovis and Borneolum Syntheticum and the lubricant granulate through pulverizing sterilization in the granule of drying or tabletting, or divide encapsulatedly, put in storage quality inspection packing back.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95108065A CN1050292C (en) | 1995-07-11 | 1995-07-11 | Anticancer drug and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95108065A CN1050292C (en) | 1995-07-11 | 1995-07-11 | Anticancer drug and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1140071A true CN1140071A (en) | 1997-01-15 |
| CN1050292C CN1050292C (en) | 2000-03-15 |
Family
ID=5076620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95108065A Expired - Fee Related CN1050292C (en) | 1995-07-11 | 1995-07-11 | Anticancer drug and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1050292C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797333A (en) * | 2010-04-21 | 2010-08-11 | 重庆希尔安药业有限公司 | Medicinal composition for treating intracranial tumours |
| US8765197B2 (en) * | 2006-02-28 | 2014-07-01 | Dong-A-Pharm, Co., Ltd. | Extract of herbal and composition containing the same |
| CN105521343A (en) * | 2016-02-24 | 2016-04-27 | 王启光 | Traditional Chinese medicinal preparation suitable for cholangiocarcinoma patients to take and preparation method of traditional Chinese medicinal preparation |
| CN105535663A (en) * | 2016-02-24 | 2016-05-04 | 王启光 | Preparation for postoperatively regulating and treating biliary duct cancer for oncology patient and preparation method |
| CN108434411A (en) * | 2018-06-28 | 2018-08-24 | 河南中医药大学 | A kind of Chinese medicine composition and preparation method thereof for treating the cancer of the esophagus |
| CN117137998A (en) * | 2023-10-27 | 2023-12-01 | 云南中医药大学 | Pharmaceutical composition for treating yin deficiency damp-heat type viral infection and pulmonary nodule, preparation and application thereof |
-
1995
- 1995-07-11 CN CN95108065A patent/CN1050292C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8765197B2 (en) * | 2006-02-28 | 2014-07-01 | Dong-A-Pharm, Co., Ltd. | Extract of herbal and composition containing the same |
| CN101797333A (en) * | 2010-04-21 | 2010-08-11 | 重庆希尔安药业有限公司 | Medicinal composition for treating intracranial tumours |
| CN105521343A (en) * | 2016-02-24 | 2016-04-27 | 王启光 | Traditional Chinese medicinal preparation suitable for cholangiocarcinoma patients to take and preparation method of traditional Chinese medicinal preparation |
| CN105535663A (en) * | 2016-02-24 | 2016-05-04 | 王启光 | Preparation for postoperatively regulating and treating biliary duct cancer for oncology patient and preparation method |
| CN108434411A (en) * | 2018-06-28 | 2018-08-24 | 河南中医药大学 | A kind of Chinese medicine composition and preparation method thereof for treating the cancer of the esophagus |
| CN117137998A (en) * | 2023-10-27 | 2023-12-01 | 云南中医药大学 | Pharmaceutical composition for treating yin deficiency damp-heat type viral infection and pulmonary nodule, preparation and application thereof |
| CN117137998B (en) * | 2023-10-27 | 2023-12-29 | 云南中医药大学 | Pharmaceutical composition for treating yin deficiency damp-heat type viral infection and pulmonary nodule, preparation and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1050292C (en) | 2000-03-15 |
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