CN103495031A - Medicament for treating ulcerative colitis - Google Patents

Medicament for treating ulcerative colitis Download PDF

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CN103495031A
CN103495031A CN201310406109.0A CN201310406109A CN103495031A CN 103495031 A CN103495031 A CN 103495031A CN 201310406109 A CN201310406109 A CN 201310406109A CN 103495031 A CN103495031 A CN 103495031A
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grams
radix
flos sophorae
rhizoma
ulcerative colitis
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CN103495031B (en
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白石根
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Abstract

A medicament for treating ulcerative colitis relates to medicaments for treating colitis, and is prepared by: selecting the following raw materials by weight: 13-17 g of radix astragali, 13-17 g of radix codonopsis, 13-17 g of bighead atractylodes rhizome, 9-15 g of semen cuscutae, 7-13 g of sophora bud, 9-15 g of sophora flower, 9-15 g of terminalia, 9-15 g of bletillastriata, 25-35 g of charred radix sanguisorbae, 13-17 g of radix paeoniae alba, 9-15 g of pomegranate rind, 9-15 g of Chinese gall, 9-15 g of red halloysite, 7-13 g of banksia rose, 7-13 g of camellia oleifera seeds, 7-13 g of cimicifugafoetida, 3-7 g of cinnamomum cassia and 3-7 g of coptis; cutting into segments or cutting into sheets or grinding into powder, adding 3000-4000 g of water, boiling until one third of water is left, filtering out residues to obtain the medicinal soup. The beneficial effect of the medicament comprise that: by employing oral and clysis, the medicament is capable of simultaneously treating principal and subordinate symptoms, and is fast in drug effect, safe, reliable, and relatively excellent in treatment effect; and 109 examples of clinical experiments show that the effective rate is 98.2%.

Description

The medicine for the treatment of ulcerative colitis
Technical field
The present invention relates to medicine, is further the medicine for the treatment of colitis, particularly treats the Chinese medicine preparation of ulcerative colitis.
Background technology
Ulcerative colitis claims again chronic non-specific ulcerative colitis, and the pathological changes multidigit, in rectum and sigmoid colon, also can spread to descending colon, even whole colon.Clinical whole symptom is diarrhoea, bloody purulent stool, stomachache and tenesmus.Modern medicine is thought self cellular immune abnormality, cause mucosa destroyed, or because Nervous and Mental Factors causes the cerebral cortex moving obstacle, autonomic nervous dysfunction and to produce intestinal movement hyperfunction, intestinal vascular smooth muscle spasm is shunk, tissue ischemia, capillary permeability increases, thereby forms inflammation, erosion and the ulcer of intestinal mucosa.
The colitis course of disease is long, obstinate, easily recurrence, treat quite thornyly, by World Health Organization (WHO), is classified as one of modern difficult treatment, is in recent years the trend of rising gradually.At present, the proctitis of western medical treatment ulcerative colitis mainly contains a few class medicines such as sulfonamides, antibiotics, hormones, immunosuppressant, said medicine all proves to have reliable therapeutic effect by the long-term test of pesticide effectiveness and clinical trial, but toxicity is large mostly, side effect is many, the symptoms such as nausea and vomiting, headache, general malaise are often arranged as oral sulfa drugs, or cause leukopenia, arthritis, erythra, albuminuria etc.; The oral gastrointestinal irritation that easily causes of antibiotic medicine, the intravenous administration side effect is large; Immunosuppressant is larger on the impact of hemopoietic function of bone marrow, answers the periodic review bone marrow smear in the medication process.
Therefore, seek to have therapeutic effect good, the Chinese medicine that untoward reaction is few or Chinese medicine and western medicine mixture just seem very urgent and needs, the research of actively developing this respect has important using value and clinical finger meaning.
Summary of the invention
Purpose of the present invention is exactly the defect existed in existing Drug therapy, and a kind for the treatment of both the principal and secondary aspects of a disease, the treatment ulcerative colitis that drug effect is rapid, safe and reliable, therapeutic effect is good, the medicine of proctitis are provided.
The objective of the invention is to realize by following scheme:
The medicine for the treatment of ulcerative colitis, it is characterized in that choosing the raw material of following weight: the Radix Astragali 13~17 grams, Radix Codonopsis 13~17 grams, the Rhizoma Atractylodis Macrocephalae 13~17 grams, Semen Cuscutae 9~15 grams, the Flos Sophorae Immaturus 7~13 grams, Flos Sophorae 9~15 grams, Fructus Chebulae's 9~15 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 9~15 grams, charred Radix Sanguisorbae 25~35 grams, the Radix Paeoniae Alba 13~17 grams, Pericarpium Granati 9~15 grams, Galla Chinensis 9~15 grams, Halloysitum Rubrum 9~15 grams, the Radix Aucklandiae 7~13 grams, Semen Camelliae 7~13 grams, Rhizoma Cimicifugae 7~13 grams, Cortex Cinnamomi 3~7 grams, Rhizoma Coptidis 3~7 grams, cutting or section or levigation, add water 3000~4000 grams, decoct to three/for the moment, filtering residue is medicinal liquid.
The present invention can further realize by following scheme:
Each component the best is: the Radix Astragali 15 grams, Radix Codonopsis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 Ke, Semen Cuscutae 12 grams, the Flos Sophorae Immaturus 10 grams, Flos Sophorae 12 grams, Fructus Chebulae's 12 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, charred Radix Sanguisorbae 30 grams, the Radix Paeoniae Alba 15 grams, Pericarpium Granati 12 grams, Galla Chinensis 12 grams, Halloysitum Rubrum 12 grams, the Radix Aucklandiae 10 grams, Semen Camelliae 10 grams, Rhizoma Cimicifugae 10 grams, Cortex Cinnamomi 5 grams, Rhizoma Coptidis 5 grams, cutting or section or levigation, add water 3500 grams, decoct to three/for the moment, filtering residue is medicinal liquid.
In the present invention: the Radix Astragali, invigorating QI to consolidate the body surface resistance, the diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, enrich blood, gas in lifting, enhancing body resistance; Radix Codonopsis, invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; The Rhizoma Atractylodis Macrocephalae, air making-up and spleen enlivening, the dampness diuretic, hidroschesis, antiabortive; Semen Cuscutae: invigorating the liver and kidney, benefit essence, improving eyesight; The Flos Sophorae Immaturus, cooling blood for hemostasis, purging liver-fire; Flos Sophorae, cooling blood for hemostasis, purging liver-fire; The Fructus Chebulae, astringing intestine to stop diarrhea is astringed the lung, the pathogenic fire reducing sore-throat relieving; The Pseudobulbus Bletillae (Rhizoma Bletillae), astringing to arrest bleeding, detumescence and promoting granulation; Charred Radix Sanguisorbae, Radix Sanguisorbae belongs to hemorrhage, has cooling blood for hemostasis, the effect of removing toxic substances sore; The common drugs (clinical many parch to black are used as medicine) such as the various hemorrhage and burn due to hot liquid or fires for the treatment of heat in blood; The Radix Paeoniae Alba: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating; Pericarpium Granati, relieving diarrhea with astringents, hemostasis, anthelmintic; Galla Chinensis, the pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating hemostasis, removing dampness sore; Halloysitum Rubrum, astringing intestine to stop diarrhea, hemostasis, promoting tissue regeneration and ulcer healing; The Radix Aucklandiae, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Semen Camelliae, circulation of qi promoting is dredged stagnant; Rhizoma Cimicifugae, deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy; Cortex Cinnamomi, mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow; Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication.
Configuration mechanism of the present invention: the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (stir-fry) replenishing QI to invigorate the spleen; The flat the kidney invigorating of Semen Cuscutae unit; The Flos Sophorae Immaturus (stir-fry), Flos Sophorae (stir-fry) freeze blood hemostasis dissipating blood stasis for subsidence of swelling; Fructus Chebulae, Pericarpium Granati, Halloysitum Rubrum antidiarrheal are killed intestinal bacteria; The hemostasis of putting on flesh of Pseudobulbus Bletillae (Rhizoma Bletillae) granulation promoting; The charred Radix Sanguisorbae hemostasis; The Radix Paeoniae Alba relieving pain by regulating nutrient QI that nourishes blood; Galla Chinensis cooling blood for hemostasis relieving diarrhea with astringents; Radix Aucklandiae regulating QI intestinal stasis relieving; Semen Camelliae circulation of qi promoting intestinal stasis relieving pain-alleviating diarrhea-relieving; Rhizoma Cimicifugae, Cortex Cinnamomi benefiting qi and raising yang; The Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.All medicine compatibilities of the present invention have the effects such as gas in heat-clearing and toxic substances removing, cooling blood for hemostasis, removing the necrotic tissue and promoting granulation, lifting, anti-inflammation, enhancing body resistance.
The invention has the beneficial effects as follows: with this medicine, adopt the oral method with coloclysis, treatment ulcerative colitis, proctitis, the medicine sick institute that goes directly, can improve the local blood drug level of enteral, the availability of medicine has obtained giving full play to, and has better reached heat-clearing and toxic substances removing, cooling blood for hemostasis, removing the necrotic tissue and promoting granulation, anti-inflammation, and contrafluxion, edema are comparatively fast recovered, the healing of local curing ulcer erosion, thus reach therapeutic purposes.Medicine of the present invention, treating both the principal and secondary aspects of a disease, drug effect is rapid, safe and reliable, curative effect is better.With 109 routine clinical trials, show, effective percentage reaches 98.2%.
Testing data:
1, cure mainly: ulcerative colitis.
2, case statistics: treat in 109 examples, male's 81 examples, women's 28 examples, age distribution is: 21 examples below 30 years old, 31~40 years old 28 example, 41~50 years old 26 example, 50~60 years old 20 example, 14 examples more than 60 years old, maximum 73 years old age, minimal ages 22 years old; The course of disease is the shortest 1 year, the longest 12 years.
3, Therapeutic Method: each oral 250 milliliters of adult, 150 milliliters, coloclysis, every day is oral twice, twice, coloclysis.It within 30 days, is a course for the treatment of.Each, interval was 3~7 days the course for the treatment of, can be again with the next course for the treatment of.General 1~2 the course for the treatment of clinical symptoms just can substantially disappear.Afterwards, re-use 1~3 course for the treatment of, consolidate curative effect, to prevent recurrence.
4, contraindication: period in a medicine, avoid eating anything raw or cold, pungent greasy, stodgy food, with cold water, do not have a bath.Anemia of pregnant woman's forbidding, forbid this product allergy sufferers.
5, efficacy assessment standard:
Cure: bloody purulent stool disappears, and stomachache disappears, and it is normal that stool recovers.Take a turn for the better: bloody purulent stool reduces, and stomachache alleviates, and the diarrhoea number of times reduces.Invalid: as not reach improvement target person.
6, therapeutic effect:
The shortest 21 days, the longest 90 days, 63 examples are cured in medication, account for 57.8%; 44 examples that take a turn for the better, account for 40.4%; Invalid 2 examples, account for 1.8%; Total effective rate 98.2%.
7, model case introduction:
Case 1: cattle so-and-so, the man, 41 years old, live the Changyuan County, Henan Province.In JIUYUE, 2011 is medical, and through a plurality of hospitals, the intestinal mirror is made a definite diagnosis, and suffers from colorectum ulcer 7 years, not good enough through the multi-treatment effect, starts to show as tenesmus, and just pus is had blood in stool often.With the oral enema treatment that adds of this medicine, positive effect was arranged in 10 days, pus and blood obviously reduces, and adheres to treating 2 months, and clinical symptoms all disappears.Recurrence that so far there are no.
Case 2: Lee so-and-so, the man, 56 years old, live Hua County, Henan Province Lao Miaoxiang, repeatedly show effect stomachache, diarrhoea, bloody purulent stool after 2 months, do colonoscopy in March, 2010 to County Hospital, be diagnosed as ulcerative colitis.Oral with coloclysis with this medicine, after 1 course for the treatment of, bloody purulent stool disappears substantially.Treat 2 courses for the treatment of, clinical symptom disappearance.Recurrence that so far there are no.
In order to make those skilled in the art person understand better the present invention program, and above-mentioned purpose of the present invention, feature and advantage can be become apparent more, below in conjunction with embodiment, the present invention is further detailed explanation.
The specific embodiment
Embodiment 1:
Choose the Radix Astragali 13 grams, Radix Codonopsis 13 grams, the Rhizoma Atractylodis Macrocephalae 13 Ke, Semen Cuscutae 9 grams, the Flos Sophorae Immaturus 7 grams, Flos Sophorae 9 grams, Fructus Chebulae's 9 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 9 grams, charred Radix Sanguisorbae 25 grams, the Radix Paeoniae Alba 13 grams, Pericarpium Granati 9 grams, Galla Chinensis 9 grams, Halloysitum Rubrum 9 grams, the Radix Aucklandiae 7 grams, Semen Camelliae 7 grams, Rhizoma Cimicifugae 7 grams, Cortex Cinnamomi 3 grams, Rhizoma Coptidis 3 grams, cutting or section or levigation, add water 3000 grams, decoct to three/for the moment, filtering residue is medicinal liquid.
Embodiment 2:
Choose the Radix Astragali 17 grams, Radix Codonopsis 17 grams, the Rhizoma Atractylodis Macrocephalae 17 Ke, Semen Cuscutae 15 grams, the Flos Sophorae Immaturus 13 grams, Flos Sophorae 15 grams, Fructus Chebulae's 15 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, charred Radix Sanguisorbae 35 grams, the Radix Paeoniae Alba 17 grams, Pericarpium Granati 15 grams, Galla Chinensis 15 grams, Halloysitum Rubrum 15 grams, the Radix Aucklandiae 13 grams, Semen Camelliae 13 grams, Rhizoma Cimicifugae 13 grams, Cortex Cinnamomi 7 grams, Rhizoma Coptidis 7 grams, cutting or section or levigation, add water 4000 grams, decoct to three/for the moment, filtering residue is medicinal liquid.
Embodiment 3:
Choose the Radix Astragali 15 grams, Radix Codonopsis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 Ke, Semen Cuscutae 12 grams, the Flos Sophorae Immaturus 10 grams, Flos Sophorae 12 grams, Fructus Chebulae's 12 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, charred Radix Sanguisorbae 30 grams, the Radix Paeoniae Alba 15 grams, Pericarpium Granati 12 grams, Galla Chinensis 12 grams, Halloysitum Rubrum 12 grams, the Radix Aucklandiae 10 grams, Semen Camelliae 10 grams, Rhizoma Cimicifugae 10 grams, Cortex Cinnamomi 5 grams, Rhizoma Coptidis 5 grams, cutting or section or levigation, add water 3500 grams, decoct to three/for the moment, filtering residue is medicinal liquid.
In each embodiment, the Rhizoma Atractylodis Macrocephalae refers to that Rhizoma Atractylodis Macrocephalae (parched), the Flos Sophorae Immaturus refer to that stir-baked FLOS SOPHORAE IMMATURUS, Flos Sophorae refer to that Flos Sophorae (parched), the Radix Paeoniae Alba refer to Radix Paeoniae Alba (parched).
The above; be only the specific embodiment of the present invention, but protection scope of the present invention is not limited to this, anyly is familiar with those skilled in the art in the technical scope that the present invention discloses; the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.

Claims (3)

1. treat the medicine of ulcerative colitis, it is characterized in that choosing the raw material of following weight: the Radix Astragali 13~17 grams, Radix Codonopsis 13~17 grams, the Rhizoma Atractylodis Macrocephalae 13~17 grams, Semen Cuscutae 9~15 grams, the Flos Sophorae Immaturus 7~13 grams, Flos Sophorae 9~15 grams, Fructus Chebulae's 9~15 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 9~15 grams, charred Radix Sanguisorbae 25~35 grams, the Radix Paeoniae Alba 13~17 grams, Pericarpium Granati 9~15 grams, Galla Chinensis 9~15 grams, Halloysitum Rubrum 9~15 grams, the Radix Aucklandiae 7~13 grams, Semen Camelliae 7~13 grams, Rhizoma Cimicifugae 7~13 grams, Cortex Cinnamomi 3~7 grams, Rhizoma Coptidis 3~7 grams, cutting or section or levigation, add water 3000~4000 grams, decoct to three/for the moment, filtering residue is medicinal liquid.
2. the medicine for the treatment of ulcerative colitis according to claim 1, it is characterized in that each component is: the Radix Astragali 15 grams, Radix Codonopsis 15 grams, the Rhizoma Atractylodis Macrocephalae 15 Ke, Semen Cuscutae 12 grams, the Flos Sophorae Immaturus 10 grams, Flos Sophorae 12 grams, Fructus Chebulae's 12 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, charred Radix Sanguisorbae 30 grams, the Radix Paeoniae Alba 15 grams, Pericarpium Granati 12 grams, Galla Chinensis 12 grams, Halloysitum Rubrum 12 grams, the Radix Aucklandiae 10 grams, Semen Camelliae 10 grams, Rhizoma Cimicifugae 10 grams, Cortex Cinnamomi 5 grams, Rhizoma Coptidis 5 grams, cutting or section or levigation, add water 3200 grams, decoct to three/for the moment, filtering residue is medicinal liquid.
3. the medicine for the treatment of ulcerative colitis according to claim 1 and 2, is characterized in that the Rhizoma Atractylodis Macrocephalae refers to that Rhizoma Atractylodis Macrocephalae (parched), the Flos Sophorae Immaturus refer to that stir-baked FLOS SOPHORAE IMMATURUS, Flos Sophorae refer to that Flos Sophorae (parched), the Radix Paeoniae Alba refer to Radix Paeoniae Alba (parched).
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103736000A (en) * 2014-02-08 2014-04-23 范红霞 Traditional Chinese medicine for treating spleen-kidney-yang deficiency syndrome ulcerative colitis
CN105168904A (en) * 2015-08-31 2015-12-23 李丽芬 Traditional Chinese medicine preparation for treating chronic gastric ulcer or duodenal ulcer
CN106581547A (en) * 2017-02-21 2017-04-26 陈秋生 Traditional Chinese medicine composition for treating enteritis in general surgery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1634303A (en) * 2004-11-08 2005-07-06 王献美 Medicine capsule for treating ulcerative colitis
CN101700358A (en) * 2009-11-12 2010-05-05 林喜彬 Medicine for treating acute and chronic nonspecific ulcerative colitis and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1634303A (en) * 2004-11-08 2005-07-06 王献美 Medicine capsule for treating ulcerative colitis
CN101700358A (en) * 2009-11-12 2010-05-05 林喜彬 Medicine for treating acute and chronic nonspecific ulcerative colitis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
黄烈生: "溃疡性结肠炎中医药治疗进展", 《黑龙江中医药》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103736000A (en) * 2014-02-08 2014-04-23 范红霞 Traditional Chinese medicine for treating spleen-kidney-yang deficiency syndrome ulcerative colitis
CN103736000B (en) * 2014-02-08 2016-03-23 范红霞 A kind of Chinese medicine for the treatment of yang deficiency of spleen and stomache ulcerative colitis
CN105168904A (en) * 2015-08-31 2015-12-23 李丽芬 Traditional Chinese medicine preparation for treating chronic gastric ulcer or duodenal ulcer
CN106581547A (en) * 2017-02-21 2017-04-26 陈秋生 Traditional Chinese medicine composition for treating enteritis in general surgery

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