CN106310035A - Traditional Chinese medicine composition capable of preventing paratyphoid fever of lambs, and preparation method thereof - Google Patents
Traditional Chinese medicine composition capable of preventing paratyphoid fever of lambs, and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition capable of preventing paratyphoid fever of lambs, and a preparation method of the composition. The traditional Chinese medicine composition is applicable to treatment of diseases of bloody flux, black scour and the like of lambs. The prescription is prepared from the following traditional Chinese medicines: lonicerae flos, radix pulsatillae, cortex phellodendri, pericarpium papaveris, and has the functions of clearing away heat and detoxifying, arresting and inducing astringency, invigorating the spleen for eliminating dampness and harmonizing the stomach and checking diarrhea. The purpose of treating the paratyphoid fever of the lambs can be achieved. The invention provides a preparation method and applications of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the functions of clearing away heat and detoxifying, arresting and inducing astringency, invigorating the spleen for eliminating dampness and harmonizing the stomach and checking diarrhea. By adopting the traditional Chinese medicine and veterinarian therapy and using pure traditional Chinese medicines, the following traditional Chinese medicines are orally taken by the lambs, and the lambs are healed fast without side effects, thus being beneficial to the growth of lambs. The traditional Chinese medicine liquor is simple to blend, and convenient to use, the cost of raw materials is low, no toxic reaction occurs after use, the healing rate is high, and no residues exist, so that the traditional Chinese medicine composition is a desirable drug for treating the paratyphoid fever of the lambs.
Description
Technical field
The present invention relates to technical field of Chinese medicine, be specifically related to a kind of Chinese medicine composition preventing and treating lamb paratyphoid fever and system thereof
Preparation Method, it is adaptable to the disease treatments such as the dysentery of lamb, black dysentery.
Background technology
Lamb paratyphoid fever belongs to sheep salmonellosis (sheep salmonellosis) and is commonly called as dysentery or black dysentery, is lamb
Acute infectious disease.It is characterized in that acute sepsis and dysentery.The most often endanger 7～15d ages lamb, it is possible to see 2～
The lamb in 3d age.Sickness rate about 30%, mortality rate about 25%.
By being by the caused lamb such as bacillus paratyphi abortus, salmonella dublin and Salmonella typhimurium
A kind of acute infectious disease, primary disease the most all can occur, and finishing period lamb often falls ill summer and early autumn.In place popular or
Distribute.Different sexes, age, the sheep of kind all have susceptibility, and wherein lamb susceptibility relatively becomes sheep high.Main infringement 7～15 days
The lamb in age, also has the lamb of 2～3 ages in days to fall ill.Sick lamb and the sheep that carries disease germs are major source of infection.Sheep of recovering can carry disease germs the several months.Sick
Former bacterium is excreted by feces, urine, milk and aborted fetus, afterbirth, amniotic fluid, pollutes feedstuff, drinking-water, instrument, pad grass etc., warp
Digestive tract and infect.Sick sheep and the breeding of strong sheep, the seminal fluid artificial insemination of sick ram also can be infected.Lamb birth 2～3 ages in days are sent out
Sick, the most in uterus infect.Owing to Salmonella generally exists in strong sheep body, especially digestive tract, lymphoid tissue and gallbladder
Capsule is especially prominent, and once external condition changes, and such as abrupt change of climate, feedstuff change or deficiency etc., makes the most emerging wind of pathogenic bacteria
Make wave, after there is autogenous infection, and propagation, make its virulence strengthen and make infection spread.General sheep hurdle sanitary condition is severe, tide
Wet, stocking density is big, crowded, and feedstuff and drinking-water lack, long-distance transport, and ewe milk is not enough, all can induce primary disease.
After morbidity lamb morbidity, spirit is depressed, weak, bows, the back of a bow, and body temperature is increased to 40～about 4l DEG C, dysentery, excrement
Just being mixed with blood in, there is colic symptoms, occur violent dysentery, initial stage dysentery to be black and be mixed with a large amount of clay coating in most of sick sheep
Sample feces.Flow out a little feces after firmly exerting duty during ill lamb defecation in mid-term, pollute its rear quarters and leg, ill lamb eating
Dunghill.Later stage dysentery is spurting, is mixed with volume blood in feces, and dewatering symptom occurs rapidly in ill lamb, enophthalmos,
Thirst and liking drink, serious exhaustion.The symptoms such as the sick sheep performance rapid breathing having, flows out mucus nose liquid, cough.Dead through 1～5 day
Die, have through the rehabilitation of 2 weeks.Sick long appearance pneumonia and arthritic symptom.Some sick sheep recovery from illness is very slow, so that growth promoter
By obstacle, and become dwarf sheep, give and cause the biggest loss on producing.Excrement it is stained with dirty with the lamb died of illness, dehydration, become thin.
Abomasum and mucous membrane of small intestine inflammation, rubescent, there is petechia.Intestinal contents is thin such as water sample, contains clot more.Mesenteric adenophyma
Greatly.Renal cortex and intracardiac adventitia have petechial hemorrhage.Stillborn fetus and dead newborn lamb, change in septicemia.Tissue edema, fill
Blood.Placental edema, hemorrhage.Splenomegaly, has Lycoperdon polymorphum Vitt focus.
Primary disease has a strong impact on the growth promoter of lamb.Therefore, in production practices, lamb paratyphoid fever (dysentery, black dysentery)
Anti-system should be considered the most important thing of sheep raising Disease Prevention work.Lamb paratyphoid fever (dysentery, black dysentery) mainly makes at present
With antibiotic therapy, although antibiotic can suppress or kill many Escherichia coli, but body intestinal is except pathogenic
Outside escherichia coli, the most substantial amounts of non-pathogenic flora, they have very important effect to the eubolism of body,
Blindly use antibiotic also by suppression or kill many non-pathogenic floras, and destroy it and form structure, have a strong impact on body
Digestive function and increase the weight of the state of an illness；Additionally long-term a large amount of use antibiotic is easily generated Drug resistance.Without restraint abuse chemical medicine, antibiotic and
Monomer medicine, had both produced polynary drug resistance and the super many drug-induced disease such as quick of receptor, and had caused again animal products to pollute, jeopardize the mankind
Food sanitation safe.Chinese medicine derives from animal, plant and mineral, containing multiple biological effective components, the most most of Chinese medicines
It is with natural plants as raw material, aboundresources, easily obtain, respond well, cheap, toxic and side effects is small, almost without residual
Stay, without Drug resistance, free from environmental pollution.Therefore, select Chinese medicine preparation to substitute chemical medicine, antibiotic is particularly important.
Summary of the invention
A kind of Chinese medicine composition preventing and treating lamb paratyphoid fever and preparation method thereof, in order to solve above-mentioned technical problem, this
Bright provide following technical scheme:
A kind of Chinese medicine composition preventing and treating lamb paratyphoid fever, is prepared by the component of following weight portion:
Flos Lonicerae 180-220 part, Radix Pulsatillae 90-110 part, Cortex Phellodendri 90-110 part, Rhizoma Dryopteris Crassirhizomatis 70-90 part, Pericarpium Papaveris 90-110
Part, Semen Arecae 55-65 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 90-110 part, Radix Sanguisorbae 90-110 part, Flos Sophorae 90-110 part, Radix Glycyrrhizae Preparata 55-65 part.
Preferably prepared by the component of following weight portion:
Flos Lonicerae 200 parts, the Radix Pulsatillae 100 parts, Cortex Phellodendri 100 parts, Rhizoma Dryopteris Crassirhizomatis 80 parts, Pericarpium Papaveris 100 parts, Semen Arecae 60 parts, Jiao three
Celestial being 100 parts, Radix Sanguisorbae 100 parts, 100 parts of Flos Sophorae, Radix Glycyrrhizae Preparata 60 parts.
The preparation method of a kind of Chinese medicine composition preventing and treating lamb paratyphoid fever, comprises the following steps:
A, once decoct
Adding the water of 8-10 times of weight portion in medical material, decoct 90 minutes, filtering medicinal residues, to leave and take filtrate standby；
B, secondary decoct
Again adding the water of 8-10 times of weight portion in medicinal residues, decoct 60 minutes, filtering medicinal residues, to leave and take filtrate standby；
C, concentrated filtrate
The filtrate of combining step A and B, filtrate stands 12 hours, takes supernatant and to be concentrated into relative density be 1.00～1.10；
D, drug solution preparing
Adding ethanol in step C concentrated supernatant makes ethanol mass concentration in solution to 80%, filter Slag recovering ethanol, add water to
The relative density of solution is 1.00～1.10, adds potassium sorbate in medicinal liquid, and the concentration of potassium sorbate is 2g/kg, and be mixed cooling
12h,
F, subpackage are sterilized
Medicinal liquid brown aseptic polyester bottles subpackage, sterilizes 40 minutes with 100 DEG C of flowing steams after subpackage.
Above-mentioned Chinese medicine composition of preventing and treating lamb paratyphoid fever and preparation method thereof, it contains in preventing and treating lamb paratyphoid fever
Drug composition and pharmaceutically acceptable adjuvant, be applied to develop the medicine of preventing and treating lamb paratyphoid fever, be particularly well-suited to lamb
Dysentery, the disease treatment such as black dysentery.
The compound medicine of the present invention is wherein:
Flos Lonicerae: sweet in the mouth, cold.Return lung, the heart, stomach warp.There is heat-clearing and toxic substances removing, effect of dispelling wind and heat pathogens.Skin ulcer, heat is treated for treating carbuncle
Toxenia dysentery, sore throat, erysipelas, the disease such as anemopyretic cold.
The Radix Pulsatillae: bitter in the mouth, cold in nature, return stomach warp, large intestine channel；There is effect of eliminating pathogenic heat from blood to cure dysentery, heat-clearing and toxic substances removing, removing dampness and killing parasites.Main
Control the diseases such as toxic-heat and blood stasis, tenesmus, damp-heat vaginal discharge, pyrexial malaria cold and heat.
Cortex Phellodendri: bitter in the mouth, cold in nature.Return kidney, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication, bring down a fever except steam.Cure mainly humid tropics
Under, pyretic stranguria tinea pedis, the disease such as dysentery jaundice.
Rhizoma Dryopteris Crassirhizomatis: bitter in the mouth, cold nature；Return liver, spleen channel.There is heat-clearing and toxic substances removing, hemostasis, effect of parasite killing.For epidemic disease sense
Emit, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation.
Pericarpium Papaveris: sour in the mouth, puckery, property is put down.Return lung, large intestine, kidney channel.There is effect of astringing lung-QI and relieving cough, astringing intestine to stop diarrhea, pain relieving, can control
Chronic cough, chronic diarrhea, chronic dysentery, proctoptosis, the disease such as have blood in stool.
Semen Arecae: bitter in the mouth；Warm in nature.Return stomach warp；Large intestine channel.There is the effect of " sending down the abnormal ascending QI row is stagnant for parasite killing, removing mass, and row aquation is wet ",
It is used for treating after malnutrition due to parasitic infestation, dyspepsia, abdominal distention, dysentery the diseases such as weight, tinea pedis, edema, malaria.
JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata): be Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), the general designation of three kinds of medicine compatibilities of Fructus Hordei Germinatus (parched to brown).Massa Medicata Fermentata (parched to brown) sweet in the mouth, pungent, property of medicine temperature.Enter
Spleen, stomach warp.Function invigorating the spleen and regulating the stomach, help digestion tune in.Fructus Crataegi (parched to brown) sour in the mouth, sweet, property of medicine tepor, return Pi, stomach, Liver Channel.Function helps digestion strong
Stomach, blood circulation promoting and blood stasis dispelling, convergence dysentery relieving.Fructus Hordei Germinatus (parched to brown) sweet in the mouth, mild in medicine property.Return spleen, stomach warp.Function circulation of qi promoting helps digestion, spleen benefiting and stimulating the appetite.Three tastes
Medicine compatibility, has food stagnation removing food stagnation effect, it is adaptable to the diseases such as inappetence, dyspepsia, gastral cavity painful abdominal mass distension.
Radix Sanguisorbae: bitter in the mouth, acid, puckery, cold nature.Return liver, large intestine channel.There are cooling blood for hemostasis, effect of removing toxic substances sore.For blood
Heat is hemorrhage waits disease.This product bitter in the mouth is trembled with fear into blood system, is longer than and expels the heat-evil and cooling blood for hemostasis；Taste is held concurrently sour and astringent, again can astringing to arrest bleeding, available Zhiduo County
Plant the card that heat in blood is hemorrhage.Decline because of its property again, therefore be especially suitable for the hematochezia of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.
Flos Sophorae: bitter in the mouth, cold nature.Return liver, large intestine channel.Have cooling blood for hemostasis, purging liver-fire it.For having blood in stool, hemorrhoidal bleeding, dysentery
Deng disease.
Radix Glycyrrhizae Preparata: property is flat, taste is put down. enter the heart, lung, spleen, stomach warp.There are invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, go phlegm and relieving cough, emergency only
Bitterly, effect of coordinating the actions of various ingredients in a prescription.
Medicine of the present invention is to use Flos Lonicerae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, Radix Pulsatillae eliminating pathogenic heat from blood to cure dysentery, heat-clearing and toxic substances removing, dampness
Parasite killing, two medicines are this card monarch drug for the treatment of.Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, can control damp-heat diarrhea；Rhizoma Dryopteris Crassirhizomatis heat-clearing and toxic substances removing,
Hemostasis, parasite killing, treat damp and hot temperature poison, sore swollen toxin, abdominal pain due to worm stagnation；Pericarpium Papaveris relieving diarrhea with astringents, pain relieving, control chronic diarrhea, chronic dysentery, take off
Anus, have blood in stool；Radix Sanguisorbae cooling blood for hemostasis, sore of detoxifying, treatment heat in blood is hemorrhage waits disease.This product bitter in the mouth is trembled with fear into blood system, is longer than and expels the heat-evil and cool
Blood stops blooding；Taste is held concurrently sour and astringent, again can astringing to arrest bleeding, the card that heat in blood is hemorrhage is planted by available Zhiduo County.Decline because of its property again, therefore be especially suitable for the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels
Hematochezia, Flos Sophorae cooling blood for hemostasis, purging liver-fire it, be used for having blood in stool, hemorrhoidal bleeding, the disease such as dysentery；Above five medicines are ministerial drug altogether.Semen Arecae kills
Worm, removing mass, sending down the abnormal ascending QI row is stagnant, and row aquation is wet, weight after treatment dyspepsia, abdominal distention, dysentery；JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) is Massa Medicata Fermentata (parched to brown), Fructus Crataegi (parched to brown), Jiao
The general designation of three kinds of medicine compatibilities of Fructus Hordei Germinatus, three taste medicine compatibility food stagnation removing food stagnations, treat the diseases such as inappetence, dyspepsia, gastral cavity painful abdominal mass distension；With
Upper four medicines are for adjuvant drug.Radix Glycyrrhizae Preparata QI invigorating and middle emergency, and can solve the poison of all medicines, can relax again the pungent strong property of all medicines for making, all
Medicine shares, treating both the principal and secondary aspects of a disease, and healthy energy is unobstructed, then evil inverse from removing.
Medicine of the present invention has heat-clearing and toxic substances removing, restrains astringent or styptic treatment for spontaneous sweating, cooling blood for hemostasis, invigorating the spleen for eliminating dampness, the function of stomach function regulating antidiarrheal.Prescription
Abundant reference Chinese veterinarian's eight guiding principles for diagnosis, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs are theoretical, giving consideration to both the exterior and interior, and QI and blood is ruled together, and special by YAOJING, compatibility is careful and precise, embodies use
Medicine is such as used military forces, and the road used military forces is essence, and the road of medication is pure prescription characteristic.
Lamb paratyphoid fever (dysentery, black dysentery) is multiple is born in summer and autumn, lamb weakness of the spleen and stomach, and transportation capabilities are not strong, the most greatly
There are the greedy cool and rotten situations such as food of turning sour of feed more, therefore think that primary disease is mainly due to gas and the unhygienic diet institute experiencing wet dirty epidemic disease poison
Cause.It is young that Chinese veterinarian thinks that the generation of primary disease is mainly (1) lamb, weakness of the spleen and stomach, and transportation capabilities are the strongest, it is impossible to by Na Shuigu and
Transporting is precise and tiny, water paddy stagnate, clear QI being mixed up with turbid QI, mix and under, then become have loose bowels.As " Jing Yue's complete work is had loose bowels " piece is so-called: " have loose bowels it
This, invariably due to taste ".(2) experiencing seasonal pathogen: the season in autumn in summer, damp is rising, if it is inappropriate to take good care of oneself, experience damp and hot foul epidemic disease it
Gas, or cool sleep in the open because of greedy, cold-damp is invaded, exopathogen oxious gas, strongly fragrant holds back middle Jiao, and taste all can be made injured, dysfunction of the spleen in transportation and transformation, disorder of QI movement,
Disorder in ascending and descending, abnormal ascent-descent between clear YANG and turbid YIN, disorderly form in the intestines and stomach and have loose bowels, damage intestinal and lower profit pus and blood.
In sum, primary disease is mainly tender and lovely because of lamb internal organs, and shape gas does not fills or congenital malformation, and the nutrition day after tomorrow is not
Foot, causes lamb weakness of the spleen and stomach and resistance to decline, experiences the gas of wet dirty epidemic disease poison, and Shi Re Bing Pian invades taste in an opponent's defence, and noxious dampness is stranded
Spleen, deficiency of spleen-QI and stomach-QI, hypoactivity of YANG in middle-JIAO, and cause mechanism of qi and stagnate, rise sending down the abnormal ascending QI disorderly, spleen main fortune transporting and sending up the lucid YANG, stomach receiving food and drink and the turbid descending
The moon, in the present, void has wet, lifting dereliction of duty, therefore is lower profit stomachache, loss of appetite；The digestive and absorptive functions generation obstacle of taste, pure and impure
Regardless of mix and under, damp and hot tenesmus, intestine and small intestine secretes and do not neglects one's duty, and water is wet a point profit can not be formed and have loose bowels, therefore excrement is dilute, stench, or poison is stagnant
In intestinal, make intestinal QI and blood block, turn to pus white, therefore dysentery color is white or band pus is white.Control suitable heat-clearing and toxic substances removing, only restrain astringent or styptic treatment for spontaneous sweating, removing heat from blood
Blood, invigorating the spleen for eliminating dampness, stomach function regulating antidiarrheal.
This prescription by Flos Lonicerae, the Radix Pulsatillae, Cortex Phellodendri, Pericarpium Papaveris, etc. traditional Chinese drug inspissation form, there is heat-clearing and toxic substances removing, convergence solid
Puckery, cooling blood for hemostasis, invigorating the spleen for eliminating dampness, the function of stomach function regulating antidiarrheal.Reach to treat the purpose of lamb paratyphoid fever (dysentery, black dysentery).
Modern veterinary's pharmacological research and clinical prolonged application it was verified that Chinese medicine has overall curative effect height, be not likely to produce
Drug resistance, remains low, the advantages such as toxic and side effects is little, and the growth of many bacteria pathogenies is had with breeding and significantly suppresses to make by it
With, even up to kill the pharmacological effect of cause of disease.The present invention according to lamb paratyphoid fever (dysentery, black dysentery) the cause of disease, fall ill machine
System, clinical pathology and drug mechanism, carry out Chinese medicine compound preventing and treating lamb paratyphoid fever (dysentery, black dysentery), develop treatment
Effect is notable, reliable in quality, and application is convenient, cheap compound Chinese medicinal preparation, and popularization and application in sheep raising produces, for promoting
The sound development entering sheep husbandry has highly important economy and social meaning.
Advantages of the present invention and have the beneficial effect that 1, the present invention uses traditional Chinese medical science veterinary treatment, uses pure Chinese medicinal components, oral
Following traditional Chinese medicines, cures fast, has no side effect, beneficially the growth of lamb after lamb is edible.2, the traditional Chinese medicine liquid modulation letter of the present invention
Single, easy to use, low raw-material cost, noresidue the highest with rear non-toxic reaction, cure rate, is that one preferably treats lamb
The medicine of sheep paratyphoid fever (dysentery, black dysentery).
The medicine of the present invention can directly gavage for lamb when specifically used.
The usage amount of the medicine of the present invention is: therapeutic dose: lamb, 3ml/kg BW, 1 time/d, be used in conjunction 5 days；Preventive dose: lamb
Sheep, 1ml/kg BW, 1 time/d, be used in conjunction 5 days.BW is lamb weight.
Detailed description of the invention
A kind of Chinese medicine composition preventing and treating lamb paratyphoid fever, is prepared by the component of following weight portion:
Flos Lonicerae 180-220 part, Radix Pulsatillae 90-110 part, Cortex Phellodendri 90-110 part, Rhizoma Dryopteris Crassirhizomatis 70-90 part, Pericarpium Papaveris 90-110
Part, Semen Arecae 55-65 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 90-110 part, Radix Sanguisorbae 90-110 part, Flos Sophorae 90-110 part, Radix Glycyrrhizae Preparata 55-65 part.
Preferably, the component of following weight portion prepare:
Flos Lonicerae 200 parts, the Radix Pulsatillae 100 parts, Cortex Phellodendri 100 parts, Rhizoma Dryopteris Crassirhizomatis 80 parts, Pericarpium Papaveris 100 parts, Semen Arecae 60 parts, Jiao three
Celestial being 100 parts, Radix Sanguisorbae 100 parts, 100 parts of Flos Sophorae, Radix Glycyrrhizae Preparata 60 parts.
The preparation method of a kind of Chinese medicine composition preventing and treating lamb paratyphoid fever, comprises the following steps:
A, once decoct
Adding the water of 8-10 times of weight portion in medical material, decoct 90 minutes, filtering medicinal residues, to leave and take filtrate standby；
B, secondary decoct
Again adding the water of 8-10 times of weight portion in medicinal residues, decoct 60 minutes, filtering medicinal residues, to leave and take filtrate standby；
C, concentrated filtrate
The filtrate of combining step A and B, filtrate stands 12 hours, takes supernatant and to be concentrated into relative density be 1.00～1.10；
D, drug solution preparing
Adding ethanol in step C concentrated supernatant makes ethanol mass concentration in solution to 80%, filter Slag recovering ethanol, add water to
The relative density of solution is 1.00～1.10, adds potassium sorbate in medicinal liquid, and the concentration of potassium sorbate is 2g/kg, and be mixed cooling
12h,
F, subpackage are sterilized
Medicinal liquid brown aseptic polyester bottles subpackage, sterilizes 40 minutes with 100 DEG C of flowing steams after subpackage.
Embodiment 1
A kind of Chinese medicine composition preventing and treating lamb paratyphoid fever, is prepared by the component of following weight portion: Flos Lonicerae 180 parts, the Radix Pulsatillae
90 parts, Cortex Phellodendri 90 parts, Rhizoma Dryopteris Crassirhizomatis 70 parts, Pericarpium Papaveris 90 parts, Semen Arecae 55 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 90 parts, Radix Sanguisorbae 90 parts, 90 parts of Flos Sophorae,
Radix Glycyrrhizae Preparata 55 parts.
Embodiment 2
A kind of Chinese medicine composition preventing and treating lamb paratyphoid fever, is prepared by the component of following weight portion: Flos Lonicerae 220 parts, the Radix Pulsatillae
110 parts, Cortex Phellodendri 110 parts, Rhizoma Dryopteris Crassirhizomatis 90 parts, Pericarpium Papaveris 110 parts, Semen Arecae 65 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 110 parts, Radix Sanguisorbae 110 parts, Flos Sophorae
110 parts, Radix Glycyrrhizae Preparata 65 parts.
Embodiment 3
A kind of Chinese medicine composition preventing and treating lamb paratyphoid fever, is prepared by the component of following weight portion: Flos Lonicerae 200 parts, the Radix Pulsatillae
100 parts, Cortex Phellodendri 100 parts, Rhizoma Dryopteris Crassirhizomatis 80 parts, Pericarpium Papaveris 100 parts, Semen Arecae 60 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 100 parts, Radix Sanguisorbae 100 parts, Flos Sophorae
100 parts, Radix Glycyrrhizae Preparata 60 parts.
Comparative experimental example
1) therapeutic test:
The present embodiment 3 use random double blind test method carried out various dose treatment natural occurrence lamb paratyphoid fever (dysentery, black
Dysentery) therapeutic test, and to select colistin sulfate injection be positive drug control group.Observe the present invention to lamb paratyphoid fever (blood
Dysentery, black dysentery) therapeutical effect, to inquire into its feasibility applied in Production of Livestock and Poultry.
Therapeutic test to the lamb paratyphoid fever (dysentery, black dysentery) of natural occurrence: by natural occurrence through clinical diagnosis and reality
Test room diagnosis to make a definite diagnosis the sick lamb of lamb paratyphoid fever (dysentery, black dysentery) and be randomly divided into 5 groups, often group 40.1-3 group is for using
Medication therapy groups of the present invention (sets three groups of basic, normal, high dosage) respectively；4th group is gentamicin injection liquid+0.5% ground plug
Meter Song+VC positive drug control group；5th group is positive controls (infecting, be not administered).Being individually insulated raising, itemized record are sick
The situations such as the symptom of lamb, healing, death.
Medication, administration time: medicine 1 group: every lamb feeds the medicine 5ml/kg BW of the present invention every day, even feed
5 days；Medicine 2 groups: every lamb feeds the medicine 3ml/kg BW of the present invention every day, even feeds 3 days；Medicine 3 groups: every lamb is every
Day feeds the medicine 1ml/kg BW of the present invention, even feeds 5 days.Positive drug control group: every lamb uses sulphuric acid celebrating the most mould every day
Element 3 mg/(kg bw)+0.5% dexamethasone 3 mg/(kg bw)+VC 5 mL/(kg bw), intramuscular injection respectively, 2～3
Secondary/d, even feeds 5 days；Positive controls: be not administered.
Experimental result:
After treatment group medicine feed 24h, the spirit of medicine group disease lamb is better than positive controls, adds up death toll, medicine after 36 h
The sick lamb of group is fewer than positive controls death toll；Observing after 48h, the improvement occurred in various degree respectively organized by medicine, positive right
Dead successively generation is still had according to group.After 3d, the spirit of medicine group disease lamb, appetite take a favorable turn and (increase from sucking amount, feeding capacity
Go out), feces is normal.
Test statistics result shows, in 40 lambs of medicine high-dose therapy group of the present invention, have 36 recoveries from illness, and 4 are still drawn
Dilute, but there is no death, cure rate is 90.0%；In 40 lambs of middle dosage treatment group, there are 35 recoveries from illness, still have loose bowels, but do not have for 5
Having death, cure rate is 87.5%；In 40 lambs of low dose therapy group, there are 29 recoveries from illness, still have loose bowels for 8, dead 3, control
More rate is 72.5%；In 40 lambs of gentamicin injection liquid+0.5% dexamethasone+VC treatment group (matched group), have 34
Only recovery from illness, still has loose bowels for 4, and has 2 death, and cure rate is 85.0%；In 40 lambs of positive controls (not being administered), have 24
Only still having loose bowels, and have 16 death, dosage treatment group mortality rate high, middle is 0.0%, and treatment group disease lamb relatively matched group disease lamb
Sheep, shows as symptom and alleviates, and the course of disease shortens, and experiment proves that the high, medium and low dosage of the present invention is to lamb paratyphoid fever (dysentery, black dysentery)
Disease has therapeutical effect, energy relief of symptoms, reduces mortality rate, and dosage high, middle is reducing mortality rate, improves the aspects such as cure rate
It is superior to the effect of gentamicin injection liquid+0.5% dexamethasone+VC.The dosage present invention high, middle can reach to cure the disease,
The effect of raising survival rate, and both zero differences in 0.05 level, therefore dosage in can using during Clinical practice, the most economical
Curative effect is the most notable.
2) prophylactic tria
At the Yang Chang that epidemic situation occurs, the lamb that 100 health do not fallen ill is randomly divided into 2 groups, often group 50, and the 1st group is that medicine is pre-
Anti-group；2nd group is matched group；1st group of every lamb gavages the medicine 10ml(of embodiment 3 every day and even feeds 7 days；2nd group does not adds
Add；Two groups of other measures of lamb are all normally sterilized by lamb immune programme for children.
Result shows: the sickness rate of chemoprophylaxis group lamb paratyphoid fever (dysentery, black dysentery) is 3.0%, and matched group sickness rate is
75.0%, and medicine group morbidity the spirit of lamb, appetite be all better than matched group, illness symptom is also light compared with matched group.Prevention group is being sent out
After being ill give with treatment after, cure rate is 86.0%；And matched group is 67.0%.
From the point of view of result of the test, the present invention has heat-clearing and toxic substances removing, restrains astringent or styptic treatment for spontaneous sweating, invigorating the spleen for eliminating dampness, cooling blood for hemostasis, stomach function regulating antidiarrheal
Function.During clinical trial, do not find that this medicine has untoward reaction.High, medium and low dosage to lamb paratyphoid fever (dysentery, black
Dysentery) disease has preferable therapeutic effect.The therapeutic effect of low dose group be less than dosage group high, middle, middle and high dosage group mortality rate,
Cure rate and total effective rate aspect there are no significant difference.Should be according to the weight of the state of an illness and treatment cost, it is proposed that clinical practice with
In (3ml/kg BW, 1 time/d) preferably, be used in conjunction 5 days.
3) contrast therapeutic test
The present embodiment 1 to 3 uses lamb paratyphoid fever (dysentery, the black dysentery) therapeutic test of same dose treatment natural occurrence, observes
The present invention is to lamb paratyphoid fever (dysentery, black dysentery) therapeutical effect, to inquire into its feasibility applied in Production of Livestock and Poultry.
Therapeutic test to the lamb paratyphoid fever (dysentery, black dysentery) of natural occurrence: by natural occurrence through clinical diagnosis and reality
Test room diagnosis to make a definite diagnosis the sick lamb of lamb paratyphoid fever (dysentery, black dysentery) and be randomly divided into 3 groups, often group 40.1-3 group is for using
Medication therapy groups of the present invention, feeds the medicine of embodiment 1 to 3 respectively.It is individually insulated raising, the symptom of itemized record disease lamb,
The situations such as healing, death.
Medication, administration time: in 3 groups, every lamb feeds the medicine 3ml/kg BW of the present invention every day, even feed 5 days.
Test statistics result shows that the cure rate of embodiment of the present invention 1-3 is all reached for more than 70.0%；Without death in three groups, complete
Complete alternative chemical synthetic drug.
The medicine of the present invention is according to listing terms of packing, in temperature: 40 DEG C ± 2 DEG C, relative humidity: under the conditions of 75% ± 5%
Acceleration study 3 months, quality is without significant change.In temperature: 25 DEG C ± 2 DEG C relative humiditys: long term test under the conditions of 60% ± 10%
24 months, quality was without significant change.Above-mentioned result of the test shows, the medicine of present invention storage quality under prescribed conditions is stable.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention,
Although being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it still may be used
So that the technical scheme described in foregoing embodiments to be modified, or wherein portion of techniques feature is carried out equivalent.
All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the present invention's
Within protection domain.
Claims (3)
1. the Chinese medicine composition preventing and treating lamb paratyphoid fever, it is characterised in that prepared by the component of following weight portion:
Flos Lonicerae 180-220 part, Radix Pulsatillae 90-110 part, Cortex Phellodendri 90-110 part, Rhizoma Dryopteris Crassirhizomatis 70-90 part, Pericarpium Papaveris 90-110
Part, Semen Arecae 55-65 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 90-110 part, Radix Sanguisorbae 90-110 part, Flos Sophorae 90-110 part, Radix Glycyrrhizae Preparata 55-65 part.
A kind of Chinese medicine composition preventing and treating lamb paratyphoid fever the most according to claim 1, it is characterised in that by following weight
The component preparation of part:
Flos Lonicerae 200 parts, the Radix Pulsatillae 100 parts, Cortex Phellodendri 100 parts, Rhizoma Dryopteris Crassirhizomatis 80 parts, Pericarpium Papaveris 100 parts, Semen Arecae 60 parts, Jiao three
Celestial being 100 parts, Radix Sanguisorbae 100 parts, 100 parts of Flos Sophorae, Radix Glycyrrhizae Preparata 60 parts.
The preparation method of a kind of Chinese medicine composition preventing and treating lamb paratyphoid fever the most according to claim 1 or claim 2, it is characterised in that
Comprise the following steps:
A, once decoct
Adding the water of 8-10 times of weight portion in medical material, decoct 90 minutes, filtering medicinal residues, to leave and take filtrate standby；
B, secondary decoct
Again adding the water of 8-10 times of weight portion in medicinal residues, decoct 60 minutes, filtering medicinal residues, to leave and take filtrate standby；
C, concentrated filtrate
The filtrate of combining step A and B, filtrate stands 12 hours, takes supernatant and to be concentrated into relative density be 1.00～1.10；
D, drug solution preparing
Adding ethanol in step C concentrated supernatant makes ethanol mass concentration in solution to 80%, filter Slag recovering ethanol, add water to
Relative density is 1.00～1.10, adds potassium sorbate in medicinal liquid, and the concentration of potassium sorbate is 2g/kg, and be mixed cooling 12h,
F, subpackage are sterilized
Medicinal liquid brown aseptic polyester bottles subpackage, sterilizes 40 minutes with 100 DEG C of flowing steams after subpackage.
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Cited By (1)
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| CN106692374A (en) * | 2017-01-23 | 2017-05-24 | 六安市绿丰牧业科技有限公司 | Traditional Chinese medicine formula for treating dysentery bloody stool of goats |
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| CN103394053A (en) * | 2013-07-18 | 2013-11-20 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103394053A (en) * | 2013-07-18 | 2013-11-20 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof |
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| CN106692374A (en) * | 2017-01-23 | 2017-05-24 | 六安市绿丰牧业科技有限公司 | Traditional Chinese medicine formula for treating dysentery bloody stool of goats |
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Application publication date: 20170111 |