CN104490712A - Traditional Chinese medicine composition with anti-aging effect and application thereof in cosmetics - Google Patents
Traditional Chinese medicine composition with anti-aging effect and application thereof in cosmetics Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition with an anti-aging effect. The composition is prepared from the following components in percentage by weight: 30-40 percent of October clematis stem, 15-25 percent of fomes japonica, 15-20 percent of lily, 10-15 percent of lily, 5-10 percent of iris tectorum and 3-5 percent of catkin. The invention further discloses a preparation method and application in cosmetics of the traditional Chinese medicine composition with the anti-aging effect. The composition has the advantages of nourishing, promoting metabolism of skin cells, improving the skin immunity and retarding skin aging, and has a remarkable nourishing and anti-aging effect when added in cosmetics.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, a kind of specifically have the Chinese medicine composition of senile-resistant efficacy and the application in cosmetics thereof.
Background technology
Vigorous and graceful skin mark health and the beauty of people, and smooth, careful and resilient skin is the target that people chase jointly.The aging of skin is a kind of natural law, although we can not stop the natural aging of skin, by scientific and effective measure, can change the aging state of skin.
The research of the traditional Chinese medical science to the mechanism of aging is of long standing and well established.The traditional Chinese medical science is thought, old and feeble genus resembles from right Now, is the miopragia with human five internal organs's six internal organs, from Inner to a series of changes of outer generation.These changes cause the function of human body day by day to decline.Theory of Chinese medical science recognizes that woman declines for being begun with yangming meridian, and aged for external tendency of describing change with face, this is mainly caused by kidney qi deficiency and coldness, weakness of the spleen and stomach, qi stagnation blood stasis, so the antidotal core of the successive dynasties traditional Chinese medical science is based on invigorating the kidney and spleen.Except tonification side's medicine, its other party medicine of selected parts, as blood circulation promoting and blood stasis dispelling, dehumidifying is reduced phlegm, circulation of qi promoting is soothing the liver, reaches anti-ageing and preserves youthful looks, supports that unit consolidates, the object of prolonging life of making light of one's life by commiting suicide.
Now, the anti-ageing external treatment that adopts of doctor trained in Western medicine is attached most importance to take stopgap measures more, though effective in cure fast advantage, curative effect is very unstable.Chinese medicine is anti-ageing to be particular about and slow to adjust thin reason, and to effect a permanent cure, curative effect is also relatively stable, this be one very traditional, but lasting effective method.
Summary of the invention
The object of the invention is, in conjunction with Chinese tradition theory of Chinese medical science basis, to provide a kind of natural safe Chinese medicine composition with senile-resistant efficacy.
The second object of the present invention is to provide the above-mentioned preparation method with the Chinese medicine composition of senile-resistant efficacy.
The third object of the present invention is to provide the application of Chinese medicine composition in cosmetics with senile-resistant efficacy.
To achieve the object of the present invention, present invention employs following technical scheme: the Chinese medicine composition with senile-resistant efficacy, be made up of the component of following percentage by weight: Caulis Clematidis apiifoliae 30 ~ 40%, Ganoderma 15 ~ 25%, Bulbus Lilii 15 ~ 20%, Cortex Moutan 10 ~ 15%, Rhizoma Iridis Tectori 5 ~ 10%, Liu Hua 3 ~ 5%.
Preferably, the Chinese medicine composition (I) described in senile-resistant efficacy is made up of the component of following percentage by weight: Caulis Clematidis apiifoliae 35%, Ganoderma 23%, Bulbus Lilii 18%, Cortex Moutan 13%, Rhizoma Iridis Tectori 7%, Liu Hua 4%.
Preferably, the Chinese medicine composition (II) described in senile-resistant efficacy is made up of the component of following percentage by weight: Caulis Clematidis apiifoliae 38%, Ganoderma 22%, Bulbus Lilii 18%, Cortex Moutan 13%, Rhizoma Iridis Tectori 6%, Liu Hua 3%.
Preferably, the Chinese medicine composition (III) described in senile-resistant efficacy is made up of the component of following percentage by weight: Caulis Clematidis apiifoliae 38%, Ganoderma 20%, Bulbus Lilii 18%, Cortex Moutan 13%, Rhizoma Iridis Tectori 7%, Liu Hua 4%.
The above-mentioned preparation method with the Chinese medicine composition of senile-resistant efficacy, it step comprised is as follows: take raw material of Chinese medicine Caulis Clematidis apiifoliae by said ratio, Ganoderma, Bulbus Lilii, Cortex Moutan, Rhizoma Iridis Tectori, Liu Hua, above-mentioned Chinese medicine is pulverized, mix homogeneously after sieving, for 1:15 ~ 1:20, to join volume fraction be in 60% ~ 80% ethanol in mass ratio, 50 ~ 80 DEG C of heating extraction 1 ~ 3h, extract 1 ~ 3 time, filter, merging filtrate, be evaporated to original volume 1/5 ~ 1/15, going up model is again D101 macroporous resin column purification, collected volume mark is 30% ~ 80% ethanol elution fraction, the mass ratio being evaporated to extracting solution and raw material of Chinese medicine is 1:0.5 ~ 1:10, add again and dissolve with the butanediol of concentrated solution equal quality, filter, obtained Chinese medicine composition extract.
The present invention has the Chinese medicine composition of senile-resistant efficacy in facial film class cosmetics, can make stable in properties, respond well anti-aging cosmetics.
The described Chinese medicine composition with senile-resistant efficacy is for preparing facial film class cosmetics, and its consumption is 2 ~ 25%, and preferable amount is 5 ~ 15%.
The invention has the beneficial effects as follows: the traditional Chinese medical science is thought, kidney is " the congenital foundation ", the raw marrow of main store essential substances, residence nephroyin and nephroyang, and kidney qi prosperity and decline is directly connected to the growth promoter of people and even the overall process of aging; Spleen is " the foundation of acquired constitution ", source of generating QI and blood, main transporting the lucid yang sending up, for human functional activity of vital energy is elevated the hinge transferred.Invigorating the kidney and spleen is the antidotal key of the traditional Chinese medical science, takes aggregate measures simultaneously, its other party medicine of selected parts, improves defying age curative effect, reaches defying age and preserves youthful looks, supports that unit consolidates, the object of prolonging life of making light of one's life by commiting suicide.
In formula of the present invention, Caulis Clematidis apiifoliae is monarch, Caulis Clematidis apiifoliae sweet in the mouth, flat, returns liver, spleen, large intestine channel, ancients think Caulis Clematidis apiifoliae sweet in the mouth greasiness, are soft and moist product, can nourish skin and eliminate dark complexion and do, record in Shennong's Herbal: " take for a long time, go dark complexion to do, good color is moistened "; Ganoderma, Bulbus Lilii, Cortex Moutan are worked in coordination with as minister, Ganoderma sweet in the mouth, temperature, tonification the five internal organs, and strengthening the body resistance, has the effect of slow down aging, record in Shennong's Herbal: " god is protected, beneficial vital essence, hard muscles and bones, good color in main deafness, sharp joint "; Bulbus Lilii is bitter, pungent, be slightly cold, GUIXIN, liver, kidney channel, clearing away heart-fire for tranquillization, nourishing YIN and moistening the lung, nourishing essence-blood, " Bencao Jingshu " medium cloud: " the cleer and peaceful of sky of holding concurrently, sweet can invigorating middle warmer, the clear then gas of heat is raw, therefore invigorating the spleen and replenishing QI "; Cortex Moutan nature and flavor are bitter, pungent, are slightly cold, GUIXIN, liver, kidney channel, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, are loaded with " except pathogen, happy color, clearance natural fibre line of meat blood vessels " in " Japan hanako materia medica "; Rhizoma Iridis Tectori is assistant, blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, removing toxic substances removing food stagnancy, says its " main broken lump in the abdomen " in Shennong's Herbal; Liu Huawei makes, and bitter in the mouth can fall to be let out, heat drop fire of dispelling cold in nature, and heat conduction is descending, says in Shennong's Herbal " can to eliminate fever sensation of the face black ".
Modern medicine proves, Caulis Clematidis apiifoliae contains starch and the phlegmatic temperament of 25.6 ~ 30.6%, effectively can improve dry and cracked rough skin situation, desalinate the mottle caused by Exposure to Sunlight, bright color, gos deep into skin and nourishes reparation, make skin consolidation flexible; Ganoderma main component is organic germanium and macromolecule polysaccharide body, can strengthen epidermis cell vigor, enhance metabolism, and improves Abwehrkraft des Koepers, regulation of physiological functions, prevents the raw wrinkle of xerosis cutis; Bulbus Lilii has the merit of good nutritious tonifying, is rich in lymphatic temperament and vitamin, useful to skin cell metabolism, has anti-ageing effect of waiting for a long time; Cortex Moutan is just used as whitening good medicine from ancient times, the antiinflammatory of external application energy, blood circulation promoting, brilliant white skin light speckle; Rhizoma Iridis Tectori can be repaired because of aging and impaired skin cell, and short skin cell self metabolism of living, extends survival and the regeneration period of skin cell, allows skin present to compact, plentiful, bullet profit; Liu Hua cures mainly edema clinically, jaundice, dark complexion and hot, there is damp color, go dark complexion dry, treat the effect such as acne vulgaris, soft skin.
All medicines share above, can Synergistic, and foster unit consolidates, qi-supplementing, blood-engendering, flourishly support skin, play the merit of conditioning viscera, Yin Yang balancing altogether, control anti-ageing preserve youthful looks this.Chinese medicine composition extract energy nutritious tonifying of the present invention, promote skin cell metabolism, improve skin immunity, delaying skin aging, makes an addition in cosmetics, and it is remarkable to nourish anti-ageing effect.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further illustrated, but these embodiments are just in order to illustrate, are not limitations of the present invention.
Embodiment 1 has Chinese medicine composition (I) and the preparation method of senile-resistant efficacy
Raw material of Chinese medicine Caulis Clematidis apiifoliae 35g is taken by proportioning, Ganoderma 23g, Bulbus Lilii 18g, Cortex Moutan 13g, Rhizoma Iridis Tectori 7g, Liu Hua 4g, above-mentioned Chinese medicine composition is pulverized, cross mix homogeneously after 80 mesh sieves, the concentration joining 2L is in 80% ethanol, 80 DEG C of heating extraction 3 times, each extraction 2 hours, cross after filtering medicine residue, merging filtrate, 600mL is evaporated at 60 DEG C, it is D101 macroporous resin column purification that above extracting solution goes up model again, collect 70% ethanol elution fraction, under 50 DEG C of conditions, concentrating under reduced pressure obtains 50g concentrated solution, add 50g butanediol again, filter, obtained 100g traditional Chinese medicine composition extract liquid.
Embodiment 2 has Chinese medicine composition (II) and the preparation method of senile-resistant efficacy
Raw material of Chinese medicine Caulis Clematidis apiifoliae 38g is taken by proportioning, Ganoderma 22g, Bulbus Lilii 18g, Cortex Moutan 13g, Rhizoma Iridis Tectori 6g, Liu Hua 3g, above-mentioned Chinese medicine composition is pulverized, cross mix homogeneously after 80 mesh sieves, the concentration joining 2L is in 80% ethanol, 80 DEG C of heating extraction 3 times, each extraction 2 hours, cross after filtering medicine residue, merging filtrate, 600mL is evaporated at 60 DEG C, it is D101 macroporous resin column purification that above extracting solution goes up model again, collect 70% ethanol elution fraction, under 50 DEG C of conditions, concentrating under reduced pressure obtains 50g concentrated solution, add 50g butanediol again, filter, obtained 100g traditional Chinese medicine composition extract liquid.
The preparation of comparative example 1-6 single medicinal material extract
Take raw material of Chinese medicine Caulis Clematidis apiifoliae 100g respectively, Ganoderma 100g, Bulbus Lilii 100g, Cortex Moutan 100g, Rhizoma Iridis Tectori 100g, Liu Hua 100g, above-mentioned Traditional Chinese drug mixture is pulverized, cross mix homogeneously after 80 mesh sieves, the concentration joining 2L is in 80% ethanol, 80 DEG C of heating extraction 3 times, each extraction 2 hours, cross after filtering medicine residue, merging filtrate, 600mL is evaporated at 60 DEG C, it is D101 macroporous resin column purification that above extracting solution goes up model again, collect 70% ethanol elution fraction, under 50 DEG C of conditions, concentrating under reduced pressure obtains 50g concentrated solution, add 50g butanediol again, filter, obtained 100g Caulis Clematidis apiifoliae extracting solution, Ganoderma extracting solution, Bulbus Lilii extracting solution, Cortex Moutan extracting solution, Rhizoma Iridis Tectori extracting solution, Liu Hua extracting solution.
The anti-ageing mask of embodiment 3 and preparation thereof
Table 1 provides the anti-ageing mask formula containing Chinese medicine composition extract of the present invention.
Table 1
Its preparation method:
1, by interpolation phase raw material methyl hydroxybenzoate and propyl hydroxybenzoate, in 1.3-butanediol, heating for dissolving is to clear in advance, for subsequent use.
2, Aqueous Phase Raw Material is fed in deionized water, is heated to 75 ~ 85 DEG C, is stirred to and is uniformly dissolved.
3, aqueous phase is cooled to 60 DEG C, slowly adds the methyl hydroxybenzoate, propyl hydroxybenzoate and the 1.3-butanediol that have dissolved in advance while stirring, is stirred to and is uniformly dissolved.
4, be cooled to 40 DEG C, add the Chinese medicine composition (I) with senile-resistant efficacy, then drip aminomethyl propanol adjust ph to 5 ~ 6.
5, stir, be cooled to 35 DEG C, 400 order dischargings after repetition measurement pH.
Embodiment 4 defying age sleep mask and preparation preparation thereof
Table 2 provides the defying age sleep mask formula containing Chinese medicine composition extract of the present invention.
Table 2
Its preparation method:
1, by oil phase raw material, stirring and dissolving is to being uniformly dispersed in advance, and by interpolation phase raw material methyl hydroxybenzoate and propyl hydroxybenzoate, in 1.3-butanediol, heating for dissolving is to clear in advance, for subsequent use.
2, Aqueous Phase Raw Material is fed in deionized water, is heated to 75 ~ 85 DEG C, is stirred to and is uniformly dissolved.
3, by oil phase under agitation (1000 ~ 2000rpm) slowly at the uniform velocity join in aqueous phase, after adding, reemulsification 5 ~ 10 minutes under homogenizing speed 4000 ~ 6000rpm.
4, be cooled to 40 DEG C, add the Chinese medicine composition (I) and essence with senile-resistant efficacy, then drip aminomethyl propanol adjust ph to 5.5 ~ 6.5.
5, stir, be cooled to 35 DEG C, the deaeration of repetition measurement pH final vacuum, filter discharging.
Prepared by comparative example 7 normal sleep facial film
Table 3 provides the normal sleep face pack prescription not containing Chinese medicine composition extract of the present invention.
Table 3
Its preparation method:
1, by oil phase raw material, stirring and dissolving is to being uniformly dispersed in advance, and by interpolation phase raw material methyl hydroxybenzoate and propyl hydroxybenzoate, in 1.3-butanediol, heating for dissolving is to clear in advance, for subsequent use.
2, Aqueous Phase Raw Material is fed in deionized water, is heated to 75 ~ 85 DEG C, is stirred to and is uniformly dissolved.
3, by oil phase under agitation (1000 ~ 2000rpm) slowly at the uniform velocity join in aqueous phase, after adding, reemulsification 5 ~ 10 minutes under homogenizing speed 4000 ~ 6000rpm.
4, be cooled to 40 DEG C, add essence, then add aminomethyl propanol adjust ph to 5.5 ~ 6.5.
5, stir, be cooled to 35 DEG C, the deaeration of repetition measurement pH final vacuum, filter discharging.
Embodiment 5 Kangshuaining mixture mud facial film and preparation thereof
Table 4 provides the Kangshuaining mixture mud face pack prescription containing Chinese medicine composition extract of the present invention.
Table 4
Its preparation method:
1, oil phase raw material is heated to 75 ~ 85 DEG C in oil phase pot, is stirred to and dissolves completely.
2, Aqueous Phase Raw Material is fed in deionized water, is heated to 75 ~ 85 DEG C, be stirred to Kaolin, toner and other Aqueous Phase Raw Material and be uniformly dispersed.
3, open homogenizing (3000 ~ 6000rpm), slow for oil phase at the uniform velocity suction aqueous phase is carried out emulsifying, emulsifying 20 minutes, open cycle water for cooling, keeps stirring.
4, be cooled to 40 DEG C, add the Chinese medicine composition (II) and essence with senile-resistant efficacy, stir.Vacuumizing and defoaming.
Embodiment 6 experimental technique and anti-senescence function evaluation
1, the preparation of sample
Respectively the Chinese medicine extract of embodiment 1 and comparative example 1-6 is made into the sample solution that concentration is 1%, tests below carrying out.
2, ultra-oxygen anion free radical Scavenging activity is evaluated
Get the Tris-HCl buffer 4.5mL of 0.05mol/L pH=8.2, preheating 20min in 25 DEG C of water-baths.Add the pyrogallol solution of 1mL sample and 0.4mL 25mmol/L again, after mixing, in 25 DEG C of water-baths, react 5min, add the HCl 1.0mL cessation reaction of 8mol/L.Make reference with Tris-HCl buffer, survey absorbance at 299nm place.The solvent of blank 1mL sample carrys out alternative sample.Clearance rate (D) is calculated according to formula (1).
Ultra-oxygen anion free radical clearance rate (%)=[1-(A2/A1)] × 100% (1)
In formula, A1 is the absorbance of blank; A2 is the absorbance of sample.
3, to the Scavenging activity evaluation of hydroxy radical
2mmol/L FeSO is added successively in 25mL color comparison tube
43mL, 1mmol/L H
2o
23mL, shakes up, and then adds 6mmol/L salicylic acid 3mL, shakes up, take out after 37 DEG C of heating in water bath 15min, survey its absorbance; Add certain density liquid to be measured respectively, shake up, continue heating in water bath 15min, take out and survey its absorbance.Following formula is the clearance rate of liquid to be measured to hydroxy radical (OH):
Scavenging action to hydroxyl free radical (%)=[A1-A2-(A1-A3)]/A1 × 100% (2)
In formula, A1 is the absorbance not adding reaction system before medicine; A2 is the absorbance of system after sample removing OH; A3 is the absorbance of system after blank removing OH.
Table 5 anti-senescence function evaluation result
Experiment shows, Chinese medicine composition of the present invention up to 79.64%, to Scavenging action to hydroxyl free radical up to 80.50%, illustrates that the synergism between compositions is remarkable to superoxide anion clearance rate, to superoxide anion and Scavenging action to hydroxyl free radical higher than single medicinal material, there is good anti-aging effects.
Embodiment 7 normal individual trial evaluation experimental
1, experimental technique
The sleep mask of embodiment 4, comparative example 7 preparation carries out normal individual trial evaluation respectively.Choose healthy volunteer 60, the age, men and women half and half at 25 ~ 50 years old.Be divided into 2 groups at random, often organize 15 male, 15 women.Each group of controlled trial of carrying out defying age sleep mask and normal sleep facial film respectively, left side uses blank sample, and right side uses routine sample on probation, uses once before sleeping night every day, continues 30 days on probation, uses the colour of skin of observing left face and right face after month.
Carry out moisturizing degree, glossiness, degree of compacting and anti-wrinkle effect evaluation to sample in use procedure, wherein best result is 5, is minimumly divided into 1.
2, experimental result
Evaluation table on probation is filled according to sensory evaluation.Collect half face experiment evaluation table on probation, statistical result is in table 6:
Table 6 normal individual trial evaluation result meansigma methods
| Evaluation result | Comparative example 7 sleep mask | Embodiment 4 sleep mask |
| Moisturizing degree | 4 points | 4 points |
| Glossiness | 3 points | 5 points |
| Degree of compacting | 1 point | 4 points |
| Anti-wrinkle effect | 2 points | 4 points |
From table 6 result, the result of human body half face test evaluation clearly can contrast effect difference of this routine sample and blank sample.Embodiment 4, comparative example 7 relatively in, the improvement aspect successful of degree of compacting and anti-wrinkle effect, show the face pack containing Chinese medicine composition extract of the present invention, there is effect that good defying age nourishes, can allow fragile coarse lax skin speedy recovery to health state, smooth exquisiteness, compacts full.
More than describe preferred embodiment of the present invention in detail, that inventor takes a large amount of manpower financial capacity and time, test of many times out result, should be appreciated that the ordinary skill of this area just design according to the present invention can make many modifications and variations without the need to creative work.Therefore, all technical staff in the art according to the present invention's design on prior art basis by logical analysis, reasoning or according to the available technical scheme of limited experiment, all should by among the determined protection domain of these claims.
Claims (8)
1. there is the Chinese medicine composition of senile-resistant efficacy, it is characterized in that, be made up of the component of following percentage by weight: Caulis Clematidis apiifoliae 30 ~ 40%, Ganoderma 15 ~ 25%, Bulbus Lilii 15 ~ 20%, Cortex Moutan 10 ~ 15%, Rhizoma Iridis Tectori 5 ~ 10%, Liu Hua 3 ~ 5%.
2. the Chinese medicine composition with senile-resistant efficacy according to claim 1, is characterized in that, is made up of the component of following percentage by weight: Caulis Clematidis apiifoliae 35%, Ganoderma 23%, Bulbus Lilii 18%, Cortex Moutan 13%, Rhizoma Iridis Tectori 7%, Liu Hua 4%.
3. the Chinese medicine composition with senile-resistant efficacy according to claim 1, is characterized in that, is made up of the component of following percentage by weight: Caulis Clematidis apiifoliae 38%, Ganoderma 22%, Bulbus Lilii 18%, Cortex Moutan 13%, Rhizoma Iridis Tectori 6%, Liu Hua 3%.
4. the Chinese medicine composition with senile-resistant efficacy according to claim 1, is characterized in that, is made up of the component of following percentage by weight: Caulis Clematidis apiifoliae 38%, Ganoderma 20%, Bulbus Lilii 18%, Cortex Moutan 13%, Rhizoma Iridis Tectori 7%, Liu Hua 4%.
5. according to the arbitrary described preparation method with the Chinese medicine composition of senile-resistant efficacy of claim 1-4, it is characterized in that, the step comprised is as follows: take raw material of Chinese medicine Caulis Clematidis apiifoliae by said ratio, Ganoderma, Bulbus Lilii, Cortex Moutan, Rhizoma Iridis Tectori, Liu Hua, above-mentioned Chinese medicine is pulverized, mix homogeneously after sieving, for 1:15 ~ 1:20, to join volume fraction be in 60% ~ 80% ethanol in mass ratio, 50 ~ 80 DEG C of heating extraction 1 ~ 3h, extract 1 ~ 3 time, filter, merging filtrate, be evaporated to 1/5 ~ 1/15 of original volume, go up macroporous resin column purification again, collected volume mark is 30% ~ 80% ethanol elution fraction, the mass ratio being evaporated to extracting solution and raw material of Chinese medicine is 1:0.5 ~ 1:10, add again and dissolve with the butanediol of concentrated solution equal quality, filter, obtained Chinese medicine composition extract.
6. be applied to according to the arbitrary described Chinese medicine composition with senile-resistant efficacy of claim 1-4 and prepare cosmetics.
7. prepare facial film class cosmetics according to the arbitrary described Chinese medicine composition with senile-resistant efficacy of claim 1-4 being applied to, its consumption is 2 ~ 25%.
8. prepare facial film class cosmetics according to the arbitrary described Chinese medicine composition with senile-resistant efficacy of claim 7 being applied to, its consumption is 5 ~ 15%.
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