CN106474291A - A kind of Chinese medicine composition with moisture-keeping efficacy and its preparation method and application - Google Patents
A kind of Chinese medicine composition with moisture-keeping efficacy and its preparation method and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q19/00—Preparations for care of the skin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention discloses a kind of Chinese medicine composition with moisture-keeping efficacy, is made up of the component for including following parts by weight：The fruit of Chinese magnoliavine 20～30, saline cistanche 15～20, date 15～20, safflower 10～15, Poria cocos 10～15, marine alga 5～10, white fungus 5～10.Invention additionally discloses the preparation method of the Chinese medicine composition with moisture-keeping efficacy and the application in cosmetics.It is an advantage of the invention that：Skin moisture-retaining capacity can be improved, is promoted skin itself that the defeated cloth of water, retaining and moisture is made, reduces skin loss of water, can also reduce skin sensitivity and maintenance is impaired, make skin that health status is returned to, make an addition in cosmetics, moisture-keeping efficacy is notable.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition with moisture-keeping efficacy and its system
Preparation Method and application.
Background technology
Moisture in human body skin can be changed with factors such as age, season, environment, health status, work as skin
When in skin, water content is relatively low, not only the dark and gloomy impact of pachylosis is attractive in appearance, can also accelerate the aging of skin, or even there is also trace
Itch, rubescent, shouting pain, the symptom such as sensitivity.So, keep the moisture in skin more importantly to maintain skin not only for attractive in appearance
Health.
Want to have that health, water is tender, bullet profit, the skin of gloss, its most important condition is exactly moisture abundance and skin in skin
Water-retaining property good.Existing beauty means lift the moisture in skin mostly by the composition of external moisturizing, so that it may immediately
Improve skin texture, promote follow-up skin-care effect and make dressing penetrating docile, so the cosmetics of replenishing water and preserving moisture are consumers
The most basic skin care item of demand.
Substantial amounts of NMF can be added on the market in most of moisturizers so which is formed in skin surface prevents moisture from steaming
Send out film, although have certain moistening effect, but can not fundamentally solve the problem that dries of skin, also have skin sense greasy and
Duration short shortcoming.
Content of the invention
The defect that the purpose of the present invention is present for prior art described above, in conjunction with Chinese tradition theory of traditional Chinese medical science basis,
A kind of natural safe Chinese medicine composition with moisture-keeping efficacy is provided.
The second object of the present invention is the preparation method for providing the above-mentioned Chinese medicine composition with moisture-keeping efficacy.
The third object of the present invention is the application for providing the Chinese medicine composition with moisture-keeping efficacy in cosmetics.
To achieve the object of the present invention, following technical scheme present invention employs：A kind of Chinese medicine group with moisture-keeping efficacy
Compound, its are made up of the component for including following parts by weight：The fruit of Chinese magnoliavine 20～30, saline cistanche 15～20, date 15～20, safranine
Spend 10～15, Poria cocos 10～15, marine alga 5～10, white fungus 5～10.
Preferably, the Chinese medicine composition with moisture-keeping efficacy, its are made up of the component for including following parts by weight：Five
Taste 30, saline cistanche 15, date 15, safflower 10, Poria cocos 10, marine alga 10, white fungus 10.
Preferably, the Chinese medicine composition with moisture-keeping efficacy, its are made up of the component for including following parts by weight：Five
Taste 25, saline cistanche 20, date 20, safflower 10, Poria cocos 10, marine alga 10, white fungus 5.
Preferably, the Chinese medicine composition with moisture-keeping efficacy, its are made up of the component for including following parts by weight：Five
Taste 30, saline cistanche 20, date 20, safflower 10, Poria cocos 10, marine alga 5, white fungus 5
The preparation method of the Chinese medicine composition with moisture-keeping efficacy is as follows the step of which includes：
(1) medicinal material pretreatment：By Removing Kernel for Date, saline cistanche, date section are dried by the difference removal of impurities cleaning of each taste Chinese medicine
Dry, Poria cocos stripping and slicing is dried in the shade, and marine alga segment is dried, and the fruit of Chinese magnoliavine, safflower and white fungus are directly dried；Weigh after process by recipe ingredient
Medicinal material, after crushing mix, obtain medicinal material mixture；
(2) extract：Medicinal material mixture is added in Extraction solvent, and the weight percent of medicinal material mixture and Extraction solvent
Than for 1：10～1：15,1～3h is extracted at 60～80 DEG C, extract 1～3 time, obtain extract；
(3) purify：Extract is filtered, and the 1/5～1/10 of former extracting liquid volume is evaporated at 50～80 DEG C, will be dense
On contracting liquid, resin model is purified for the macroporous resin column of D101 or AB-8, and collected volume specific concentration is 50～80% ethanol elution portions
Point；
(4) concentrate：It is 1 liquid to be evaporated to step (1) Chinese medicine mixture weight percentage at 30～50 DEG C：1
～1：10, the 1,3-PD dissolving with the liquid equal quality after concentration is added, is filtered, obtains with moisture-keeping efficacy
Drug composition extract.
The Extraction solvent is the ethanol water of volume by volume concentration 60～80%.
The Chinese medicine composition with moisture-keeping efficacy can be used in cosmetics, its addition in cosmetic formulations
For accounting for the 0.5～20% of total formula weight, preferred addition is account for total formula weight 5～15%.
What traditional Chinese medicine beauty was adhered to is the theory progress of " overall, balance, nature ", and the healthy water profit of skin depends merely on outside
Moisturizing is inadequate, will support, work along both lines and really could effect a permanent cure outside interior tune.The traditional Chinese medical science thinks that skin water profit has close pass with internal organs
System：The spleen being the foundation of acquired constitution, source of generating QI and blood, spleen and stomach function are normal, and qi and blood is vigorous, and human body can just have the moisture of abundance；Lung has
The effect that a surname sends out, has the ability of defeated cloth aqueous, makes body obtain moistening foster moistening；The main water of kidney, aqueous nourish people by the defeated cloth whole body of lung
After body, be collected in kidney again, in the presence of kidney, secrete clear not turbid, to maintain internal normal water liquid measure.So, traditional Chinese medical science moisturizing should
This is the process of a comprehensively regulating, by conditioning viscera, during replenishing water and preserving moisture, it is also possible to prevent sending out for other diseases
Raw.
For a better understanding of the present invention, the principle of the invention is described as follows by spy：In inventive formulation, with the fruit of Chinese magnoliavine it is
Monarch, its are warm in nature, and taste is sour, sweet, return lung, the heart, kidney channel, can restrain astringent or styptic treatment for spontaneous sweating, and nourishing generate fluid, kidney calming, physical fitness, SUN Si miao are recognized
For " the informal dress fruit of Chinese magnoliavine, with the gas of beneficial lung gold, then grows source upper, in lower then kidney tonifying "；Saline cistanche collaboration date is minister, saline cistanche taste
Sweet, salty, warm in nature, return kidney, large intestine channel, can kidney-replenishing, benefiting essence-blood, ease constipation road,《Bencao Jingshu》Think it be " nourshing kidney replenishing vital essence and blood it
Key medicine "；Date is warm in nature, sweet, returns spleen, stomach, with strengthening the spleen and stomach, yin and blood nourishing, mental-tranquilization the effect of, Li Shizhen (1518-1593 A.D.) exists
《Compendium of Materia Medica》In say its " can tonifying middle-Jiao and Qi, nourishes blood and promotes the production of body fluid "；Safflower collaboration Poria cocos is assistant, during safflower is famous and precious simply
Medicinal material, its are sweet mild-natured, the thoughts of returning home, Liver Channel, can be promoting blood circulation and removing blood stasis, dissipate Yu Kaijie；Poria cocos is sweet, light, mild-natured, the thoughts of returning home, lung, spleen, kidney
Warp, its have the effect of clearing damp and promoting diuresis, invigorating the spleen calming heart,《Amplification on Materia Medica》Say its " work(of row water is many "；Marine alga collaboration white fungus is for making, extra large
Algae bitter, salty, cold in nature, return lung, spleen, kidney, liver stomach, the scattered stasis of blood of energy softening hard masses, profit water detumescence,《Book on Chinese herbal medicine covers bamboo fish trap》Think that it can " Li Shui
Road "；White fungus is tonic medicine simply, sweet, light, mild-natured, attaches to the lung and stomach meridians, has nourishing Yin and moistening lung, tonifying spleen appetizing and beneficial gas gut purge
Effect, the laudatory title for having " hat in bacterium ".
Modern medicine proves that the fruit of Chinese magnoliavine contains schizandrin, vitamin C, resin, tannin and a small amount of carbohydrate, has anti-ageing staying
Face, nti-freckle please color and anti-oxidant effect；The composition of saline cistanche be benzyl carbinol glycoside, iridoids, lignanoids, polysaccharide, ten
Several amino acid and multiple alkaloids, preserve youthful looks with nourishing, the effect of black hair of invigorating blood circulation；Red date contains protein, fat, carbohydrate, has
Machine acid, vitamin and abundant amino acid, can make gloss of having rosy cheeks, and promote the metabolism of skin cell, prevent melanin from sinking
, anti-aging；Safflower contains crocin, bayer acid dimethyl ester etc., can improve the supply of blood oxygen, moisture and nutrition, also
The growth maintenance of damaged blood vessels cell can be promoted, recovered skin and compact；Methionine, cystine in marine alga enriches, and can prevent
Only dry skin, makes Dry be rich in gloss, safeguards epithelial tissue healthy growth, reduces pigment spot and desalination scar；Silver
Ear is rich in natural characteristic colloid, with skin-moisturizing, skin, and can dispel face's chloasma, freckle.
Above all medicines share, this solid unit strong, interior tune is outer to support, and balances internal organs, promotes skin itself to make water and the defeated cloth of moisture, with
Make water, water delivery, retaining be moisturizing this, to reduce mark of the skin loss of water as moisturizing, while going back, repairing is impaired, antioxygen
Change, anti-aging and desalination color spot, strengthen beauty and skin care effect.The Chinese medicine composition extract of the present invention can improve skin moisturizing energy
Power, makes skin return to health status, makes an addition in cosmetics, and moisture-keeping efficacy is notable.
The present invention is nursed one's health while skin moisture evaporation is prevented using the theory progress of the traditional Chinese medical science " overall, balance, nature "
Skin, fundamentally solves the problems, such as that skin makes water, water delivery, retaining, effectively alleviates scaly dry skin, and persistently effective.
Compared with prior art, the present invention has the advantages that：Skin moisture-retaining capacity can be improved, promotes skin itself
The defeated cloth of water, retaining and moisture is made, reduces skin loss of water, can also reduce skin sensitivity and maintenance is impaired, return to skin
Health status, makes an addition in cosmetics, and moisture-keeping efficacy is notable.
Specific embodiment
In order to preferably illustrate present invention, illustrated with some preferably specific embodiments below.But these tools
Body embodiment is simply to illustrate that present disclosure, rather than present invention is limited.
Embodiment 1
A kind of Chinese medicine composition with moisture-keeping efficacy, is made up of the parts by weight Chinese medicine component in formula as below table：
| Component | Parts by weight |
| The fruit of Chinese magnoliavine | 22～28 |
| Saline cistanche | 16～18 |
| Date | 16～19 |
| Safflower | 11～14 |
| Poria cocos | 11～13 |
| Marine alga | 6～9 |
| White fungus | 6～8 |
Preparation method is as follows：
(1) by Removing Kernel for Date, then by the difference removal of impurities cleaning of each taste Chinese medicine, saline cistanche, date section are dried, Poria cocos is cut
Block dries in the shade, and marine alga segment is dried, and the fruit of Chinese magnoliavine, safflower and white fungus are directly dried, and weighs the medicinal material after processing, powder by recipe ingredient
Mix after broken, obtain medicinal material mixture；
(2) it is 1 with the percentage by weight of Extraction solvent to add medicinal material mixture：12 volume by volume concentration is 80% ethanol water
Solution is extracted as Extraction solvent, under 80 DEG C of temperature conditionss 3 times, extracts 1.5h every time, is filtered, merging filtrate, is carried
Take liquid；
(3) extract is evaporated under 60 DEG C of temperature conditionss the 1/5 of original volume, concentrate is obtained, will be dense
On contracting liquid, resin model is purified for the macroporous resin column of D101 or AB-8, and collected volume fraction is 70% ethanol elution part；
(4) it is 1: 5-8 to be evaporated to liquid under the conditions of 50 DEG C with step (1) Chinese medicine mixture weight percentage,
The 1,3-PD with the liquid equal quality after concentration is added, is filtered after dissolving.
Embodiment 2
A kind of Chinese medicine composition with moisture-keeping efficacy, is made up of the parts by weight Chinese medicine component in formula as below table：
| Component | Weight/g |
| The fruit of Chinese magnoliavine | 30 |
| Saline cistanche | 15 |
| Date | 15 |
| Safflower | 10 |
| Poria cocos | 10 |
| Marine alga | 10 |
| White fungus | 10 |
Preparation method is as follows：
(1) first by Removing Kernel for Date, then by the difference removal of impurities cleaning of each taste Chinese medicine, saline cistanche, date section are dried, Fu
Siberian cocklebur stripping and slicing is dried in the shade, and marine alga segment is dried, and the fruit of Chinese magnoliavine, safflower and white fungus are directly dried, and weighs the medicine after processing by recipe ingredient
Material, mixes after crushing, obtains medicinal material mixture；
(2) add 1L volume by volume concentration for 80% ethanol water as Extraction solvent, carry under 80 DEG C of temperature conditionss
Take 3 times, extract 1.5h every time, filter, merging filtrate, obtain extract；
(3) extract is evaporated to 200mL under 60 DEG C of temperature conditionss, concentrate is obtained, will set on concentrate
The macroporous resin column purifying of fat model D101 or AB-8, collected volume fraction is 70% ethanol elution part；
(4) reduced pressure concentration obtains 50g concentrate under the conditions of 50 DEG C, adds 50g 1,3-PD, filters, obtain after dissolving
There is the Chinese medicine composition extract of moisture-keeping efficacy to 100g.
Embodiment 3
A kind of Chinese medicine composition with moisture-keeping efficacy, is made up of the parts by weight Chinese medicine component in formula as below table：
| Component | Weight/g |
| The fruit of Chinese magnoliavine | 25 |
| Saline cistanche | 20 |
| Date | 20 |
| Safflower | 10 |
| Poria cocos | 10 |
| Marine alga | 10 |
| White fungus | 5 |
Preparation method is as follows：
(1) first by Removing Kernel for Date, then by the difference removal of impurities cleaning of each taste Chinese medicine, saline cistanche, date section are dried, Fu
Siberian cocklebur stripping and slicing is dried in the shade, and marine alga segment is dried, and the fruit of Chinese magnoliavine, safflower and white fungus are directly dried, and weighs the medicine after processing by recipe ingredient
Material, mixes after crushing, obtains medicinal material mixture；
(2) add 1L volume by volume concentration for 80% ethanol water as Extraction solvent, carry under 80 DEG C of temperature conditionss
Take 3 times, extract 1.5h every time, filter, merging filtrate, obtain extract；
(3) extract is evaporated to 200mL under 60 DEG C of temperature conditionss, concentrate is obtained, will set on concentrate
The macroporous resin column purifying of fat model D101 or AB-8, collected volume fraction is 70% ethanol elution part；
(4) reduced pressure concentration obtains 50g concentrate under the conditions of 50 DEG C, adds 50g 1,3-PD, filters, obtain after dissolving
There is the Chinese medicine composition extract of moisture-keeping efficacy to 100g.
Embodiment 4
A kind of Chinese medicine composition with moisture-keeping efficacy, is made up of the parts by weight Chinese medicine component in formula as below table：
Preparation method is as follows：
(1) first by Removing Kernel for Date, then by the difference removal of impurities cleaning of each taste Chinese medicine, saline cistanche, date section are dried, Fu
Siberian cocklebur stripping and slicing is dried in the shade, and marine alga segment is dried, and the fruit of Chinese magnoliavine, safflower and white fungus are directly dried, and weighs the medicine after processing by recipe ingredient
Material, mixes after crushing, obtains medicinal material mixture；
(2) add 1L volume by volume concentration for 80% ethanol water as Extraction solvent, carry under 80 DEG C of temperature conditionss
Take 3 times, extract 1.5h every time, filter, merging filtrate, obtain extract；
(3) extract is evaporated to 200mL under 60 DEG C of temperature conditionss, concentrate is obtained, will set on concentrate
The macroporous resin column purifying of fat model D101 or AB-8, collected volume fraction is 70% ethanol elution part；
(4) reduced pressure concentration obtains 50g concentrate under the conditions of 50 DEG C, adds 50g 1,3-PD, filters, obtain after dissolving
There is the Chinese medicine composition extract of moisture-keeping efficacy to 100g.
Embodiment 5
A kind of moisturizing mask of the Chinese medicine composition containing with moisture-keeping efficacy, which is by following table mass percent component system
Become：
Table 1
The Preparation Method of the moisturizing mask of the Chinese medicine composition containing with moisture-keeping efficacy is as follows：
(1) glycerine in A phase and Sodium Hyaluronate are emulsified pot with pre-dispersed rear input of glycerine, by EDETATE SODIUM and propylene
Acyl dimethyltaurine ammonium/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers direct plunges into emulsification pot, is warmed to 80 DEG C
Dispersed with stirring is complete to dissolving.
(2) by the methyl hydroxybenzoate in B phase and Nipasol butanediol and the advance heating for dissolving of 1,3- propane diols to transparent.
(3) A phased soln is lowered the temperature completely afterwards, adds B phase when being cooled to 60 DEG C, stirs to dissolving completely, cooling.
(4) to 45 DEG C spend when add C phase, dispersed with stirring to dissolving completely,
(5) and then 37 degree are cooled to, stir exquisiteness, inspection color, pH, fragrance, the physical and chemical index such as outward appearance, vacuumize
Deaeration, 200 mesh filtering and discharging after the assay was approved.
Embodiment 6
A kind of moisturizing face cream of the Chinese medicine composition containing with moisture-keeping efficacy, which is by following table mass percent component system
Become：
Table 2
The preparation method of the moisturizing face cream of the Chinese medicine composition containing with moisture-keeping efficacy：
(1) in advance 1,3-BDO and Sodium Hyaluronate are evenly stirred until transparent, it is 1% that Carbomer is made into mass fraction
Aqueous dispersions.
(2) A phase raw material is put into oil phase pot and 80 DEG C is heated to, stir to dissolving completely.
(3) 1,3-BDO that handles well through step (1), Sodium Hyaluronate and other B phase raw materials are put into emulsification pot to add
Heat is stirred to dissolving completely to 80 DEG C.
(4) by quick for A phase suction agitated kettle, add after finishing, with the speed emulsifying 5 of 4000～6000rpm～
10 minutes, emulsify continuously stirred with the speed of 1000～2000rpm after terminating and start to lower the temperature.
(5), when being down to 65 DEG C, the aqueous dispersions that the mass fraction for preparing through step (1) is 1% are added, with 4000～
The speed homogeneous of 6000rpm 2 minutes.
(6) treat that temperature is cooled to 45 DEG C, C phase is added, stir to being uniformly dissolved.
(7) vacuum defoamation after temperature is down to 35 DEG C, inspection color, fragrance, the physical and chemical index such as outward appearance, after the assay was approved
200 mesh filtering and dischargings.
The preparation of 1～5 single medicinal material extract of comparative example
Chinese medicine material fruit of Chinese magnoliavine 100g, saline cistanche 100g, date 100g, marine alga 100g, white fungus 100g are weighed respectively, will be upper
State clean, removal of impurities, drying, crushing, after crossing 80 mesh sieves, the concentration that is added separately to 1L is in 80% alcohol, 80 DEG C heating extractions 3
Secondary, extract 1.5 hours every time, after being filtered to remove medicine residue, merging filtrate, 200mL is evaporated at 60 DEG C, is more than carried
Take liquid and go up model D101 macroporous resin column purifying again, 70% alcohol elution fraction is collected, reduced pressure concentration is obtained under the conditions of 50 DEG C
50g concentrate, adds 50g 1,3-PD, filters, and 100g single medicinal material extract is obtained.
The preparation of 6～10 single medicinal material facial mask of comparative example
A kind of common facial mask containing single medicinal material extract, is made up of the component of following mass percent：
Table 3
Preparation method is as follows：
(1) glycerine in A phase and Sodium Hyaluronate are emulsified pot with pre-dispersed rear input of glycerine, by EDETATE SODIUM and propylene
Acyl dimethyltaurine ammonium/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers direct plunges into emulsification pot, is warmed to 80 DEG C
Dispersed with stirring is complete to dissolving.
(2) by the methyl hydroxybenzoate in B phase and Nipasol butanediol and the advance heating for dissolving of 1,3- propane diols to transparent.
(3) A phased soln is lowered the temperature completely afterwards, adds B phase when being cooled to 60 DEG C, stirs to dissolving completely, cooling.
(4) to 45 DEG C spend when add C phase, dispersed with stirring to dissolving completely,
(5) and then 37 degree are cooled to, stir exquisiteness, inspection color pH, fragrance, the physical and chemical index such as outward appearance, vacuumize
Deaeration, 200 mesh filtering and discharging after the assay was approved.
The preparation of the common face cream of comparative example 11
A kind of do not contain the common face cream that the present invention has moisture-keeping efficacy Chinese medicine composition, by following mass percent
Component is made：
Table 4
Its preparation method：
(1) in advance 1,3-BDO and Sodium Hyaluronate are evenly stirred until transparent, it is 1% that Carbomer is made into mass fraction
Aqueous dispersions.
(2) A phase raw material is put into oil phase pot and 80 DEG C is heated to, stir to dissolving completely.
(3) 1,3-BDO that handles well through step (1), Sodium Hyaluronate and other B phase raw materials are put into emulsification pot to add
Heat is stirred to dissolving completely to 80 DEG C.
(4) by quick for A phase suction agitated kettle, add after finishing, with the speed emulsifying 5 of 4000～6000rpm～
10 minutes, emulsify continuously stirred with the speed of 1000～2000rpm after terminating and start to lower the temperature.
(5), when being down to 65 DEG C, the aqueous dispersions that the mass fraction for preparing through step (1) is 1% are added, with 4000～
The speed homogeneous of 6000rpm 2 minutes.
(6) treat that temperature is cooled to 45 DEG C, C phase is added, stir to being uniformly dissolved.
(7) vacuum defoamation after temperature is down to 35 DEG C, inspection color, fragrance, the physical and chemical index such as outward appearance, after the assay was approved
200 mesh filtering and dischargings.
1 skin moisture content of experimental example and skin moisture are lost in the test of (TEWL)
Moisture content test uses universally acknowledgedMethod capacitance method, skin moisture are lost in TEWL pair
The function of assessment skin moisture protective layer is very important parameter, has been obtained for extensive accreditation in the world.Skin is protected
Sheath is more intact, and the content of moisture content will be higher, and the numerical value that skin moisture is lost in TEWL is lower.Moisture of skin test can be in time
It was found that whether the defencive function of skin is destroyed.
1.1 tester
The skin moisture content Corneometer test that German Courage+Khazaka company (German CK company) manufactures
Probe.The skin moisture that German Courage+Khazaka company (German CK company) manufactures is lost in (TEWL) Tewameter
TM300 test probe.
1.2 skin moisture content and TEWL method of testing
Embodiment 5 and comparative example 6～10 are carried out experiment below.
Dry skin crowd (tingling sensation adds up >=3 points of persons) 120 is chosen, the age, men and women half and half at 20～45 years old.At random
It is divided into 6 groups, per group 10 male sex, 10 women.Any product (cosmetics or topical drug can not be used within 15 days before recipient site
Or health products for oral administration).Before test, it is desirable to which experimenter's cleaning cleaning facial area simultaneously enters 22 ± 1 DEG C of temperature in 2 hours after cleaning,
Sit quietly in the constant temperature and humidity room of humidity 50 ± 5% 30min, and keeps relaxation state.
Half of face test is carried out by random table in experiment, side is the case study on implementation 5 containing Chinese medical extract, and opposite side is
Comparative example 6～10, the left and right nasolabial groove part for choosing volunteer carry out skin moisture content measuring and moisture loss (TEWL) survey
Examination, takes the number of data (D0) and nasolabial groove skin moisture loss (TEWL) of the mean value of 3 values as nasolabial groove water content
According to (D0).After test terminates, volunteer need to be by using, and side face smears a kind of product, and opposite side face smears another kind of product.
Continuous on probation 28 days, and require that the 14th day (D14) and the 28th day (D28) that test is paid a return visit.
1.3 experimental result
5 water content of table test rate of change unit (%)
Experimental example 2 is releived sensitive effect of stimulation functional evaluation
2.1 facial area lactic acid stimulate efficacy assessment method of testing
Half of face test is carried out by random table in experiment, side is the case study on implementation 6 containing Chinese medical extract, and opposite side is
Comparative example 11, selects experimenter's nasolabial groove position to be tested, 10% lactic acid solution 50ul is dropped in the individual layer of a diameter of 0.8cm
On filter paper, experimenter's tingling sensation is inquired in 3min, 4min and 5min respectively, scored by 4 point-scores (0 is divided into without tingling sensation,
1 is divided into slight shouting pain, and 2 are divided into moderate shouting pain, and 3 are divided into severe shouting pain), the scoring for recording volunteer is commented as side lactic acid stimulation
Divide (D0).Daily sooner or later carry out product for 2 times on request to smear, continuous on probation 28 days, and the 14th day (D14) requiring to test and the
(D28) is paid a return visit within 28 days.
2.2 experimental result
6 contrast test result unit (%) of table
By table 5 and 6 data display of table, what the result of half face test evaluation of human body can be apparent contrasts experimental example and contrast
Effect difference of example, the wherein moisturiser containing Chinese medicine composition are good to skin moisturization, and which can effectively increase cuticula
Moisture content water content, reduces the external moisture loss of keratoderma, and has certain repair, skin sensitivity of releiving
Reduce lactic acid effect of stimulation.
Shown by test, other embodiment also has similar effect.
Therefore, the Chinese medicine composition that the present invention has moisture-keeping efficacy can improve skin moisture-retaining capacity, promote skin certainly
Body makes the defeated cloth of water, retaining and moisture, reduces skin loss of water, can also reduce skin sensitivity and maintenance is impaired, recover skin
To health status
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, other any Spirit Essences without departing from the present invention and the change that is made under principle, modification, replacement, combine, simplify,
Equivalent replacement mode is all should be, is included within protection scope of the present invention.
Claims (8)
1. a kind of Chinese medicine composition with moisture-keeping efficacy, it is characterised in that be made up of the component for including following parts by weight：Five
Taste 20～30, saline cistanche 15～20, date 15～20, safflower 10～15, Poria cocos 10～15, marine alga 5～10, white fungus 5～
10.
2. a kind of Chinese medicine composition with moisture-keeping efficacy according to claim 1, it is characterised in that following heavy by including
The component of amount number is made：The fruit of Chinese magnoliavine 30, saline cistanche 15, date 15, safflower 10, Poria cocos 10, marine alga 10, white fungus 10.
3. a kind of Chinese medicine composition with moisture-keeping efficacy according to claim 1, it is characterised in that following heavy by including
The component of amount number is made：The fruit of Chinese magnoliavine 25, saline cistanche 20, date 20, safflower 10, Poria cocos 10, marine alga 10, white fungus 5.
4. a kind of Chinese medicine composition with moisture-keeping efficacy according to claim 1, it is characterised in that following heavy by including
The component of amount number is made：The fruit of Chinese magnoliavine 30, saline cistanche 20, date 20, safflower 10, Poria cocos 10, marine alga 5, white fungus 5.
5. a kind of preparation method of Chinese medicine composition with moisture-keeping efficacy according to claim 1, it is characterised in that bag
The step of including is as follows：
(1) medicinal material pretreatment；
(2) extract：Medicinal material mixture is added in Extraction solvent, and medicinal material mixture with the percentage by weight of Extraction solvent is
1：10～1：15,1～3h is extracted at 60～80 DEG C, extract 1～3 time, obtain extract；
(3) purify：Extract is filtered, the 1/5～1/10 of former extracting liquid volume is evaporated at 50～80 DEG C, by concentrate
Upper resin model is purified for the macroporous resin column of D101 or AB-8, and collected volume specific concentration is 50～80% ethanol elution parts；
(4) concentrate：It is 1 liquid to be evaporated to step (1) Chinese medicine mixture weight percentage at 30～50 DEG C：1～1：
10, add the 1,3-PD dissolving with the liquid equal quality after concentration.
6. a kind of preparation method of Chinese medicine composition with moisture-keeping efficacy according to claim 5, it is characterised in that institute
State ethanol water of the Extraction solvent for volume by volume concentration 60～80%.
7. a kind of Chinese medicine composition with moisture-keeping efficacy according to claim 1 is applied in cosmetics, and its feature exists
In：Addition in cosmetic formulations is account for total formula weight 0.5～20%.
8. a kind of Chinese medicine composition with moisture-keeping efficacy according to claim 7 is applied in cosmetics, and its feature exists
In：Addition in cosmetic formulations is account for total formula weight 5～15%.
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| CN114732777A (en) * | 2022-05-12 | 2022-07-12 | 广州宏众生物科技有限公司 | Composition with moisturizing and relieving effects and preparation method thereof |
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| CN114732777A (en) * | 2022-05-12 | 2022-07-12 | 广州宏众生物科技有限公司 | Composition with moisturizing and relieving effects and preparation method thereof |
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