CN114732777A - Composition with moisturizing and relieving effects and preparation method thereof - Google Patents
Composition with moisturizing and relieving effects and preparation method thereof Download PDFInfo
- Publication number
- CN114732777A CN114732777A CN202210512807.8A CN202210512807A CN114732777A CN 114732777 A CN114732777 A CN 114732777A CN 202210512807 A CN202210512807 A CN 202210512807A CN 114732777 A CN114732777 A CN 114732777A
- Authority
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- China
- Prior art keywords
- extract
- composition
- moisturizing
- filtrate
- weight
- Prior art date
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- Granted
Links
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 73
- 230000000694 effects Effects 0.000 title claims abstract description 64
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 80
- 239000007788 liquid Substances 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
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- 238000002156 mixing Methods 0.000 claims abstract description 26
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- 239000002537 cosmetic Substances 0.000 claims abstract description 20
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- 239000000463 material Substances 0.000 claims abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 41
- 239000000706 filtrate Substances 0.000 claims description 39
- 239000006228 supernatant Substances 0.000 claims description 31
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 20
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- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 2
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- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
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- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 6
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
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- 235000019154 vitamin C Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and particularly relates to a composition with moisturizing and relieving effects, a preparation method and an application thereof, wherein the composition comprises the following components in percentage by weight: 0.1-2.0% of oat extract, 0.5-5.0% of tremella extract, 0.1-2.0% of cactus extract, 0.1-1.0% of fucus extract, 10.0-50.0% of polyalcohol and the balance of deionized water. The preparation method comprises the steps of material preparation, fermentation, decoloration, concentration and blending, the composition with the moisturizing and relieving effects can be stored in a liquid form without freeze-drying, and the composition has high stability and long shelf life and can keep the activity of the active ingredients to the maximum extent. The composition is applied to a cosmetic product, so that the skin moisturizing capability can be improved, the skin can be promoted to generate water, store water and distribute water, the skin moisture loss is reduced, the skin sensitivity and repairing damage can be reduced, and the skin can be recovered to a healthy state.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a composition with moisturizing and relieving effects, and a preparation method and application thereof.
Background
The first requirements for a skin with health, moisture, elasticity and luster are that the skin has sufficient moisture and that the skin has good water retention. Most of the existing cosmetic means can improve the moisture content of skin by external moisture-retaining components, so that the skin texture can be immediately improved, the subsequent skin-care effect is promoted, and the makeup is smooth and comfortable, so that the cosmetic with water replenishing and moisture retaining functions is a basic skin-care product which is most demanded by consumers.
Most moisturizing products in the market are added with a large amount of moisturizing agents to form a film for preventing moisture evaporation on the surface layer of skin, and although the moisturizing products have a certain moisturizing effect, the problem of skin dryness cannot be fundamentally solved, and the moisturizing products also have the defects of greasy skin feel and short duration. As is well known, many natural active ingredients contain polysaccharide, amino acid, vitamin, polyphenol and other ingredients, so that the skin can be well moisturized, relieved, aged and conditioned, and the skin can be restored to a healthy state of water-wet elasticity, but the effect of the raw materials is difficult to be expected due to the limitations of extraction solvents, processes, preparation methods and the like of extracts prepared by the traditional process, and although the fermentation technology can extract smaller-molecular active nutrient substances from natural plant resources, the effect is enhanced, the toxicity is reduced, the effectiveness and the absorbability of the raw materials are improved, the activity of the raw materials is ensured by additionally adding preservative ingredients, and the introduction of the preservative ingredients has the hidden danger of sensitization.
Chinese patent CN110559241A developed a preservative-free composition with moisturizing and soothing effects comprising oat extract, tremella extract, cactus extract and seaweed extract. However, the patent application adopts a freeze-drying method in the preparation process, and the introduction of the freeze-drying method increases the complexity of the production process and the production cost, and may cause the loss of active ingredients in the process of re-dissolving the freeze-dried powder.
The present invention is a newer generation product of CN110559241A, and the inventors found that the moisturizing and soothing efficacy of the composition can be significantly enhanced by adding a specific kind of seaweed extract to the composition, and that not only the moisturizing and soothing efficacy of the composition can be enhanced but also the composition can be stably stored in a liquid form without lyophilization by adding a specific kind of polyol to the composition. The composition with the moisturizing and relieving effects has high stability and long shelf life, and can keep the activity of the effective components to the maximum extent.
Disclosure of Invention
In order to overcome the defects and shortcomings in the prior art, the invention aims to provide a natural, safe, stable and efficient composition with moisturizing and relieving effects.
In order to achieve the purpose of the invention, the invention adopts the following technical scheme:
a composition with moisturizing and relieving effects comprises the following components in percentage by weight: 0.1-2.0% of oat extract, 0.5-5.0% of tremella extract, 0.1-2.0% of cactus extract, 0.1-1.0% of fucus extract, 10.0-50.0% of polyalcohol and the balance of deionized water.
Further preferably, the composition with moisturizing and soothing effects comprises the following components in percentage by weight: 0.4 to 0.8 percent of oat extract, 1.0 to 2.0 percent of tremella extract, 0.4 to 0.8 percent of cactus extract, 0.3 to 0.5 percent of fucus extract, 25.0 to 40.0 percent of polyalcohol and the balance of deionized water.
Further preferably, the composition with moisturizing and soothing effects comprises the following components in percentage by weight: 0.8% of oat extract, 2.0% of tremella extract, 0.8% of cactus extract, 0.5% of fucus extract, 30.0-35.0% of polyhydric alcohol and the balance of deionized water.
The polyalcohol comprises at least one of glycerol, dipropylene glycol, butanediol, propylene glycol and 1, 2-pentanediol, and 1, 2-hexanediol and ethylhexylglycerin.
Preferably, the polyol consists of glycerol, 1, 2-hexanediol and ethylhexylglycerol.
Still further preferably, the composition with moisturizing and soothing effects comprises the following components in percentage by weight: 0.8% of oat extract, 2.0% of tremella extract, 0.8% of cactus extract, 0.5% of fucus extract, 30.0% of glycerol, 2.0% of 1, 2-hexanediol, 0.05% of ethylhexyl glycerol and the balance of deionized water.
The second purpose of the invention is to provide a preparation method of the composition with moisturizing and relieving effects.
In order to achieve the purpose of the invention, the invention adopts the following technical scheme:
a method for preparing a composition with moisturizing and soothing effects comprises the following steps:
(1) pretreatment: respectively preparing filtrate of oat, tremella, cactus and Fucus vesiculosus for later use;
(2) fermentation/decolorization/concentration: fermenting the filtrate obtained in the step (1) to respectively prepare oat, tremella, cactus and fucus extract, and specifically comprises the following steps:
and (3) oat extract: according to the following steps, the ratio of zymophyte liquid I, honey and oat filtrate is 5-50 mL: 5-30 g: selecting raw materials according to the proportion of 100-;
white fungus extract: according to the following steps, 5-20mL of zymophyte liquid II, honey and tremella filtrate: 10-30 g: selecting raw materials according to the proportion of 50-100g, uniformly mixing, placing the prepared solution in the environment of 35-42 ℃ for fermentation for 5-7 days, centrifuging for 15-30min at 8000-10000r/min, taking the supernatant, adding activated carbon accounting for 3% of the weight of the supernatant, decoloring for 40min at 80 ℃, collecting the decolored liquid, and concentrating to 1/5% of the weight of the supernatant to obtain the tremella extract;
cactus extract: according to the following steps, 1-10mL of zymophyte liquid III, honey and cactus filtrate: 5-10 g: selecting raw materials according to the proportion of 50-200g, uniformly mixing, placing the prepared solution in the environment of 25-30 ℃ for fermentation for 7-10 days, centrifuging for 15-30min at 8000-10000r/min, taking supernatant, adding activated carbon accounting for 3% of the weight of the supernatant, decoloring for 40min at 80 ℃, collecting decolored liquid, and concentrating to 1/5% of the weight of the supernatant to obtain the cactus extract;
fucus vesiculosus extract: and (3) setting the fermentation bacterium liquid IV, honey and the fucus vesiculosus filtrate to be 5-20 mL: 20-50 g: selecting raw materials according to the proportion of 100-300g, uniformly mixing, placing the prepared solution in an environment of 25-30 ℃ for fermentation for 5-10 days, centrifuging for 15-30min at 8000-10000r/min, taking supernatant, adding activated carbon accounting for 3% of the weight of the supernatant, decoloring for 40min at 80 ℃, collecting decolored liquid, and concentrating to obtain 1/5 parts of the weight of the supernatant, namely the fucus extract;
(3) blending: and (3) mixing and stirring the extracts in the step (2) uniformly according to the proportion of the composition with the moisturizing and relieving effects in the first purpose, and sterilizing to obtain the composition.
Preferably, the specific preparation steps of the filtrate in the step (1) are as follows:
oat filtrate: sieving oat after impurity removal and crushing by a sieve of 80-200 meshes to obtain oat powder, and sieving the oat powder according to the weight ratio of amylase: oat flour: deionized water 0.001 g: 10-30 g: preparing solution by using 100-300mL, performing enzymolysis on the solution at the temperature of 32-38 ℃ and under the condition of pH value of 5.8-6.2 for 40-60min, and filtering to obtain filtrate for later use;
white fungus filtrate: sieving the tremella subjected to impurity removal and crushing by a sieve of 80 meshes, and mixing the tremella powder: deionized water is 1: 20-1: 40 taking materials, adding the tremella powder into deionized water, mixing and pulping, collecting pulp, adding pectinase accounting for 0.03-0.06% of the weight of the pulp into the pulp, carrying out enzymolysis for 2-4h at 35-38 ℃, and sieving by a 200-mesh sieve to obtain filtrate for later use;
cactus filtrate: cleaning radix et caulis Opuntiae Dillenii, removing spines and skin, cutting mesophyll, homogenizing with a homogenizer for 1-3min, filtering, and collecting filtrate;
fucus vesiculosus filtrate: cutting the rehydrated dried sea oak into pieces according to the mass ratio of the feed liquid of 1:5-1:10 adding deionized water, mixing and pulping, collecting the pulp, adding food grade pectase accounting for 0.03-0.06% of the weight of the pulp, performing enzymolysis at 35-38 ℃ for 1-3h, filtering with 200-mesh gauze, and taking the filtrate for later use.
Preferably, in the step (2), the zymocyte liquid I is Saccharomyces Cerevisiae (Saccharomyces Cerevisiae) in the form of suspension, and the concentration of the zymocyte liquid I is 2.0 x 106-108cfu/mL, pH 6.5-7.5; the zymocyte liquid II is prepared by mixing Lactobacillus plantarum (Lactobacillus plantarum) and Saccharomyces Cerevisiae (Saccharomyces Cerevisiae) according to a weight ratio of 2: 1, at a concentration of 2.0X 106-108cfu/mL, pH 6.5-7.5;
the zymocyte liquid III is prepared from Lactobacillus delbrueckii, Lactobacillus fermentum and Saccharomyces Cerevisiae (Saccharomyces Cerevisiae) according to the weight ratio of 2: 3: 1, in a concentration of 2.0X 106-108cfu/mL, pH 6.5-7.5;
the zymophyte liquid IV is prepared from Lactobacillus plantarum (Lactobacillus plantarum), Lactobacillus fermentum (Lactobacillus fermentum) and Lactobacillus acidophilus (Lactobacillus acidophilus) according to the weight ratio of 1: 1:1, in a concentration of 2.0X 106-108cfu/ml, pH 6.5-7.5.
The third purpose of the invention is to provide the application of the composition with moisturizing and relieving effects in preparing cosmetics.
Preferably, the cosmetic comprises at least one of a lotion, a milk, a serum, a cream, a mask, a face cleanser, or a BB cream.
Preferably, the composition with moisturizing and relieving effects is contained in the cosmetic in an amount of 0.05% -1% by weight of the cosmetic.
Further preferably, the composition with moisturizing and soothing effects is added into the cosmetic in an amount of 0.1% -0.5% by weight of the cosmetic.
Specifically, the invention provides moisturizing essence with a moisturizing effect, which comprises the following components in percentage by mass:
in the invention, in the process of long-term production research, the inventor deeply excavates effective species with water replenishing, moisture preserving, skin moisturizing, soothing and sensitivity in raw materials and reasonably compounds the following components: oat has natural health care function and high beauty value, people have long understood that oat is used for treating dry skin and itching, contains protein, vitamin, beta-glucan, oat oil and other components, and has the effects of resisting oxidation, increasing skin activity, delaying skin aging, whitening and moisturizing, reducing wrinkles and stains, resisting allergy and the like; tremella contains abundant mucopolysaccharides such as glucose, fucoidan, pentose and mannitol, has a structure very similar to that of hyaluronic acid, has excellent moisturizing capability, smaller molecules and higher absorption and permeation speed, and is a natural high-quality moisturizing component; the fresh cactus contains rich protein, mineral substances, cellulose, vitamin C and the like, and also contains rich active functional components such as SOD, flavonoids, polysaccharides and the like, so that the cactus can moisturize, store water, protect skin, resist inflammation and infection and promote the regeneration and repair of cells; fucus vesiculosus contains abundant sulfated polysaccharide and viscous polysaccharide, is an excellent emollient, and active substances in the Fucus vesiculosus can be combined with skin protein to form a moisturizing gel, and can form a protective film on the surface of skin through hydration to prevent water evaporation, and meanwhile, the Fucus vesiculosus also has the effects of resisting bacteria, diminishing inflammation, controlling oil, removing acnes and repairing damage.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, four compositions of oat, tremella, cactus and fucus are applied to cosmetics after being processed by the processing method, the prepared composition does not need freeze-drying processing, can be transported and stored at normal temperature, has long shelf life, and can furthest keep the activity and value of active ingredients; the composition of the invention comprises a plurality of components with moisturizing and relieving effects, the effects of the components are coordinated, the water locking and water producing capability of the skin can be enhanced, the skin can be helped to recover the moisturizing elasticity, the skin defense capability can be enhanced, and the skin sensitivity and repair damage can be resisted.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
Preparation examples
Example 1
A composition with moisturizing and soothing effects is prepared by the following steps:
1) pretreatment of
Crushing the naked oat which is sorted out and has been subjected to impurity and particle screening, sieving the crushed naked oat by a 200-mesh sieve, and mixing the crushed naked oat with the amylase, the oat powder and the deionized water according to the dosage ratio of 0.001 g: 15 g: 200mL, carrying out enzymolysis for 50min at 35 ℃ and pH 6.0, filtering, and taking the filtrate for later use.
Crushing tremella, sieving with a 80-mesh sieve, and mixing the materials according to a feed liquid mass ratio of 1: 25 adding into deionized water, mixing, pulping, collecting the pulp, adding pectase 0.05 wt% of the pulp into the pulp, performing enzymolysis at 37 deg.C for 2h, sieving with 200 mesh sieve, and collecting the filtrate.
Cleaning radix et caulis Opuntiae Dillenii, removing spines and skin, cutting mesophyll, homogenizing for 2min with homogenizer, and filtering to obtain filtrate.
Cutting the rehydrated dried sea oak into pieces according to the mass ratio of the feed liquid of 1:5-1:10 adding deionized water, mixing and pulping, collecting the pulp, adding food grade pectase accounting for 0.05 percent of the weight of the pulp, carrying out enzymolysis for 1-3 hours at 37 ℃, filtering with 200-mesh gauze, and taking the filtrate for later use.
2) Fermentation/decolorization/concentration
The dosage ratio of the zymophyte liquid I, the honey and the oat filtrate is 10 mL: 20 g: 250g of fermentation liquor I is prepared. Fermenting the fermentation liquor I at 25-32 ℃ for 12 days, centrifuging at 8000r/min for 15min, taking supernatant, adding activated carbon with the weight of 3% of that of the supernatant, decolorizing at 80 ℃ for 40min, collecting decolorized solution, and concentrating to 1/5% of that of the supernatant, thus obtaining the oat extract. Wherein the zymocyte liquid I is Saccharomyces Cerevisiae (Saccharomyces Cerevisiae) existing in suspension form, and has concentration of 2.0 × 106-108cfu/mL, pH of 6.5-7.5, and the honey is sophora flower honey.
The dosage ratio of the zymophyte liquid II to the honey to the tremella filtrate is 15 mL: 20 g: 100g of fermentation liquor II is prepared. And fermenting the fermentation liquor II at 38 ℃ for 7 days, centrifuging at 8000r/min for 15min, taking supernatant, adding activated carbon accounting for 3% of the weight of the supernatant, decoloring at 80 ℃ for 40min, collecting decolored liquid, and concentrating to obtain 1/5% of the weight of the supernatant, namely the tremella extract. Wherein, the zymocyte liquid II is prepared by mixing Lactobacillus plantarum (Lactobacillus plantarum) and Saccharomyces Cerevisiae (Saccharomyces Cerevisiae) according to the weight ratio of 2: 1 in a concentration of 2.0X 106-108cfu/mL, pH 6.5-7.5, and the honey is litchi honey.
The using amount ratio of the zymophyte liquid III to the honey to the cactus filtrate is 5 mL: 5 g: 150g of fermentation liquor III is prepared. Fermenting the fermentation liquor III at 26 ℃ for 8 days, centrifuging at 8000r/min for 15min, collecting supernatant, adding activated carbon 3 wt% of the supernatant, decolorizing at 80 ℃ for 40min, collecting decolorized solution, and concentrating to obtain supernatant 1/5, which is the cactus extract. Wherein the fermentation bacterium liquid III is prepared from Lactobacillus delbrueckii, Lactobacillus fermentum and Saccharomyces Cerevisiae (Saccharomyces Cerevisiae) according to the weight ratio of 2: 3: 1, in a concentration of 2.0X 106-108cfu/mL, pH of 6.5-7.5, and Mel is Astragalus sinicus Mel.
The using amount ratio of the zymophyte liquid IV to the honey to the kelp filtrate is 15 mL: 40 g: 200g of fermentation liquor IV is prepared. And fermenting the fermentation liquor IV at 28 ℃ for 10 days, centrifuging at 8000r/min for 15min, filtering to obtain supernatant, taking supernatant, adding activated carbon accounting for 3% of the weight of the supernatant, decoloring at 80 ℃ for 40min, collecting decolored liquid, and concentrating to obtain supernatant of 1/5 weight, namely the fucus extract. Wherein the fermentation bacterium liquid IV is Lactobacillus plantarum (Lactobacillus plantarum), Lactobacillus fermentum (Lactobacillus fermentum) and Lactobacillus acidophilus (Lactobacillus acidophilus) according to the proportion of 1: 1:1, in a concentration of 2.0X 106-108cfu/mL, pH 6.5-7.5, the honey is sophora flower honey and jujube flower honey according to the proportion of 2: 1.
The above strains were purchased from the culture collection of microorganisms of the institute of microorganisms, Guangdong province.
3) Blending:
the extract in the step (2) is prepared from the following components in percentage by weight: 0.8% of oat extract, 2.0% of tremella extract, 0.8% of cactus extract, 0.5% of fucus extract, 30.0% of glycerol, 2.0% of 1, 2-hexanediol, 0.05% of ethylhexyl glycerol and the balance of deionized water. Mixing, stirring, and sterilizing to obtain composition (I) with effects of keeping moisture and relieving.
Example 2
Compared with the embodiment 1, the composition (II) with the moisturizing and relieving effects in the embodiment 2 comprises the following components in percentage by weight: 1.5% of oat extract, 1.0% of tremella extract, 1.5% of cactus extract, 0.3% of fucus extract, 30.0% of glycerol, 2.0% of 1, 2-hexanediol, 0.05% of ethylhexyl glycerol and the balance of deionized water, and the preparation method is the same as that in example 1.
Example 3
Compared with the embodiment 1, the composition (III) with the moisturizing and relieving effects in the embodiment 3 comprises the following components in percentage by weight: 0.1% of oat extract, 5.0% of tremella extract, 2.0% of cactus extract, 0.1% of fucus extract, 30.0% of glycerol, 2.0% of 1, 2-hexanediol, 0.05% of ethylhexyl glycerol and the balance of deionized water, and the preparation method is the same as that of example 1.
Example 4: preparation of moisturizing and relieving essence
Table 1 shows the formula of moisturizing essence containing the composition of the present invention.
TABLE 1
The preparation method comprises the following steps:
(1) pre-dispersing xanthan gum and sodium hyaluronate in the phase A by using glycerol, putting the pre-dispersed xanthan gum and sodium hyaluronate into an emulsifying pot, directly putting EDTA disodium, glycerol polyacrylate and PEG/PPG/polytetramethylene glycol-8/5/3 glycerol into the emulsifying pot, heating to 80 ℃, stirring and dispersing until the EDTA disodium, the glycerol polyacrylate and the PEG/PPG/polytetramethylene glycol-8/5/3 are completely dissolved.
(2) The p-hydroxyacetophenone in the phase B is dissolved in butanediol, 1, 3-propanediol and 1, 2-hexanediol by heating in advance until the solution is transparent.
(3) Cooling after the A phase is completely dissolved, adding the B phase when the temperature is reduced to 60 ℃, stirring until the B phase is completely dissolved, cooling to 37 ℃, uniformly stirring and refining, checking physicochemical indexes such as color, pH, fragrance and appearance, vacuumizing and defoaming, filtering with 200 meshes after the inspection is qualified, discharging, and filling.
(4) And (3) independently vacuum-packaging the phase C, and adding the phase C into the prepared phase (3) before use.
Example 5: preparation of moisturizing and relieving essence
The same conditions as in example 4 were used except that the composition (I) having moisturizing and soothing effects was changed to the composition (II) having moisturizing and soothing effects, as compared with example 4.
Example 6: preparation of moisturizing and relieving essence
The same conditions as in example 4 were used except that the composition (I) having moisturizing and soothing effects was changed to the composition (III) having moisturizing and soothing effects as compared with example 4.
Comparative example 1:
compared with example 1, the fucus is replaced by the following components in the weight ratio of 1: 2, the other conditions were the same as in example 1.
Comparative example 2:
in comparison with example 1, no polyol was contained, and other conditions were the same as in example 1.
Comparative example 3:
the polyol contained only glycerol as compared with example 1, and the other conditions were the same as in example 1.
Comparative example 4: the composition is prepared by a conventional hot reflux process
In comparison with example 1, comparative example 11 directly takes plant material in the ratio of 1:5-1:10 percent of deionized water is added, reflux extraction is carried out for 2 times at 80 ℃, dregs of a decoction are filtered, decolorization and concentration are carried out until the same proportion as that of the example 1, and 30.0 percent of glycerol, 2.0 percent of 1, 2-hexanediol, 0.05 percent of ethyl hexyl glycerol and the balance of deionized water are added according to the weight percentage. Mixing, stirring, and sterilizing to obtain composition comparative example 4.
Comparative examples 5 to 8: preparation of moisturizing and soothing essence Using comparative examples 1-4
The same conditions as in example 4 were set to comparative examples 5 to 8, except that the composition (i) having moisturizing and soothing effects was changed to comparative examples 1 to 4 as compared to example 4, and the prepared moisturizing and soothing essence containing comparative examples 1 to 4 was set to comparative examples 5 to 8.
Comparative example 9: preparation of common essence
The general essence of the combination (i) for removing moisturizing effect was set as comparative example 9 in the same condition as example 4 except that the composition (i) for moisturizing and soothing effects was not added as in example 4.
Effects of the embodiment
Effect example 1: product stability test
The stability test of the product mainly takes heat resistance, cold resistance and freeze-thaw cycle as main tests to verify the stability of the product.
1.1 Heat and Cold resistance test
The heat and cold resistance test is to place the sample in an incubator or refrigerator at 45 ℃ or-18 ℃ respectively, and observe the stability of recovering to room temperature after 1 day, 3 days, 7 days, 15 days, 30 days, 45 days, 60 days, 75 days and 90 days.
1.2 Freeze-thaw cycling test
The main method of the freeze-thaw cycle test is to freeze and thaw the mixture back and forth at the temperature of-5 ℃ and normal temperature, the cycle is carried out for 3 times, and the appearance condition is observed and recorded.
1.3 test results
TABLE 2 stability statistics
The data in Table 2 shows that the addition of the composition to the product system clearly compares the differences between the examples and the comparative examples. The concrete expression is as follows: when the composition does not contain the polyhydric alcohol or the polyhydric alcohol is only glycerol, a product added with the composition has poor stability in a heat resistance test and a freeze-thaw test, and is particularly characterized in that indexes such as appearance, viscosity and the like of the product are greatly changed. The results of this experiment suggest that whether or not a polyol is added to the composition of the present invention and the particular type of polyol added have a great effect on the stability of the product comprising the composition of the present invention. In addition, the composition treated by the conventional hot reflux extraction is added into a product, has great influence on physical and chemical indexes such as appearance, viscosity and the like of a system, and has very remarkable formula stability after being treated by the method. The compositions of the present invention are shown to have superior stability over conventional actives.
Effect example 2: testing of skin moisture content and skin moisture loss (TEWL)
The moisture test adopts the recognized method
The method-capacitance method, TEWL is an important parameter for evaluating the function of the skin moisture protective layer, and has been widely accepted internationally. The more intact the skin protection layer, the higher the moisture content and the lower the value of TEWL for skin moisture loss. The skin moisture test can find out in time whether the protective function of the skin has been destroyed.
2.1 test Instrument
A skin moisture content Corneometer test probe manufactured by Courage + Khazaka, germany (CK, germany). Skin moisture loss (TEWL) Tewameter TM300 test probe manufactured by Courage + Khazaka, Germany (CK).
2.2 skin moisture content and TEWL test methods
The products of examples 4 to 6 and comparative examples 5, 7 to 8 were subjected to the following experiments.
36 dry skin people (people with the accumulated stabbing pain feeling more than or equal to 3 points) are selected, the age is 20-45 years old, and the age is half of that of men and women. Groups were randomized into 3 groups of 6 males and 6 females. Any product (cosmetics or external medicines or internal health care products) cannot be used for 15 days before the tested part. Before the test, the subject was asked to wash and cleanse the face and sit still for 30min in a constant temperature and humidity room at a temperature of 22 + -1 deg.C and a humidity of 50 + -5% 2 hours after the washing, and to maintain a relaxed state.
In the experiment, a half face test is carried out according to a random table, one side is an example 4-6, the other side is a comparative example 5, 7-8, the left nasolabial sulcus part and the right nasolabial sulcus part of a volunteer are selected to carry out a skin moisture content test and a moisture loss (TEWL) test, and the average value of 3 values is taken as the data (D0) of the nasolabial sulcus moisture content and the data (D0) of the nasolabial sulcus skin moisture loss (TEWL). After the test is finished, the volunteers need to use the product according to the requirements, one side face is coated with one product, and the other side face is coated with the other product. Trial was continued for 28 days and required a return visit on day 14 (D14) and day 28 (D28) of the trial.
2.3 results of the experiment
Table 3: moisture content test Change Rate Unit (%)
The results of skin hydration and TEWL are shown by the data in Table 3 to clearly compare the efficacy differences between the examples and the comparative examples. The concrete expression is as follows: the fucus in example 4 was replaced by the following materials in the weight ratio of 1: 2, the moisturizing effect of the product of comparative example 5 on the skin is much deteriorated, which indicates that the moisturizing effect of the product comprising the composition of the present invention may be related to the specific kinds of the ingredients in the composition of the present invention, that is, it is not possible to combine any kind of seaweed extract with the oat extract, the tremella extract and the cactus extract so that the product comprising the composition of the present invention has a significant moisturizing effect. The moisturizing effect on skin of the product of comparative example 6 was much less good after removal of the polyol composition of example 4, indicating that the moisturizing effect of the product comprising the composition of the invention may additionally be related to the combination of polyols in the composition of the invention. In addition, as shown in comparative example 8, the composition treated by the conventional hot reflux extraction also has poor moisturizing effect on the skin, which shows that the treatment process according to the present invention can ensure the activity of the product more and make the moisturizing effect of the product more excellent.
Effect example 3: functional assessment of soothing sensitive stimulus effects
3.1 evaluation and test method for lactic acid stimulation efficacy of face
The products of examples 4 to 6 and comparative examples 5, 7 to 8 were subjected to the following experiments.
36 dry skin people (with the cumulative stabbing pain feeling more than or equal to 3 points) are selected, the age is 20-45 years, and the age is half of that of men and women. Groups were randomized into 3 groups of 6 males and 6 females. Any product (cosmetics or external medicines or internal health care products) cannot be used for 15 days before the tested part.
In the experiment, a half-face test was performed according to a random schedule, one side was examples 4 to 6, and the other side was comparative examples 5 and 7 to 8, and the nasolabial sulcus of the subject was selected for the test, 50 μ L of a 10% lactic acid solution was dropped on a single-layer filter paper having a diameter of 0.8cm, the subject was asked for stinging sensation at 3min, 4min and 5min, respectively, and the score was made by 4 points (0 point was no stinging sensation, 1 point was mild stinging, 2 point was moderate stinging, and 3 point was severe stinging), and the score of the volunteer was recorded as the lactic acid stimulation score of the side (D0). The product is applied as required 2 times a day, and the application is continued for 28 days, and the 14 th (D14) and 28 th (D28) days of the test are required for revisit.
3.2 results of the experiment
Table 4: lactic acid stimulation test result change rate unit (%)
The data in table 4 show that the evaluation results of the human half-face test can clearly compare the efficacy difference between the examples and the comparative examples. The concrete expression is as follows: the fucus in example 4 was replaced by the following materials in the weight ratio of 1: 2, the soothing effect of the product according to comparative example 5 on skin sensitivity is much worse, which indicates that the soothing effect of the product comprising the composition of the present invention may be related to the specific kind of each ingredient in the composition of the present invention, that is, it is not possible to combine any kind of seaweed extract with the oat extract, the tremella extract and the cactus extract to give the product comprising the composition of the present invention a significant soothing effect on skin. The soothing effect on skin sensitivity of the product of comparative example 7 was much less pronounced after removal of the polyol composition of example 4, indicating that the soothing effect on skin of the product comprising the composition of the invention may additionally be related to the combination of polyols in the composition of the invention. In addition, as shown in comparative example 8, the composition treated by the conventional hot reflux extraction also has poor effect of relieving skin allergy, which shows that the treatment process according to the invention can ensure the activity of the product and ensure that the product has more excellent effect of relieving skin allergy.
In conclusion, the composition having moisturizing and soothing effects according to the present invention can be stored in a liquid form without lyophilization, has high stability and a long shelf life, and can maximally maintain the activity of active ingredients. The composition is applied to a cosmetic product, so that the skin moisturizing capability can be improved, the skin can be promoted to generate water, store water and distribute water, the skin moisture loss is reduced, the skin sensitivity and repairing damage can be reduced, and the skin can be recovered to a healthy state.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (9)
1. The composition with the effects of moisturizing and relieving is characterized by comprising the following components in percentage by weight: 0.1-2.0% of oat extract, 0.5-5.0% of tremella extract, 0.1-2.0% of cactus extract, 0.1-1.0% of fucus extract, 10.0-50.0% of polyalcohol and the balance of deionized water.
2. The moisturizing and soothing composition as claimed in claim 1, comprising the following components in percentage by weight: 0.4 to 0.8 percent of oat extract, 1.0 to 2.0 percent of tremella extract, 0.4 to 0.8 percent of cactus extract, 0.3 to 0.5 percent of fucus extract, 25.0 to 40.0 percent of polyalcohol and the balance of deionized water.
3. The moisturizing and soothing composition as claimed in claim 2, comprising the following components in percentage by weight: 0.8% of oat extract, 2.0% of tremella extract, 0.8% of cactus extract, 0.5% of fucus extract, 30.0-35.0% of polyhydric alcohol and the balance of deionized water.
4. The composition with moisturizing and soothing effects as claimed in claim 1,2 or 3, wherein the polyol comprises at least one of glycerin, dipropylene glycol, butylene glycol, propylene glycol, 1, 2-pentanediol, and 1, 2-hexanediol, ethylhexylglycerin.
5. A process for the preparation of a moisturizing and soothing composition according to any one of claims 1 to 4, comprising the steps of:
(1) pretreatment: respectively preparing filtrate of oat, tremella, cactus and Fucus vesiculosus;
(2) fermentation/decolorization/concentration: fermenting the filtrate obtained in the step (1) to respectively prepare oat, tremella, cactus and fucus extract, and specifically comprises the following steps:
and (3) oat extract: according to the following steps, the ratio of zymophyte liquid I, honey and oat filtrate is 5-50 mL: 5-30 g: selecting raw materials according to the proportion of 100-;
white fungus extract: according to the following steps, 5-20mL of zymophyte liquid II, honey and tremella filtrate: 10-30 g: selecting raw materials according to the proportion of 50-100g, uniformly mixing, placing the prepared solution in the environment of 35-42 ℃ for fermentation for 5-7 days, centrifuging for 15-30min at 8000-10000r/min, taking the supernatant, adding activated carbon accounting for 3% of the weight of the supernatant, decoloring for 40min at 80 ℃, collecting the decolored liquid, and concentrating to 1/5% of the weight of the supernatant to obtain the tremella extract;
cactus extract: according to the proportion that 1-10mL of zymophyte liquid III, honey and cactus filtrate: 5-10 g: selecting raw materials according to the proportion of 50-200g, uniformly mixing, placing the prepared solution in the environment of 25-30 ℃ for fermentation for 7-10 days, centrifuging for 15-30min at 8000-10000r/min, taking supernatant, adding activated carbon accounting for 3% of the weight of the supernatant, decoloring for 40min at 80 ℃, collecting decolored liquid, and concentrating to 1/5% of the weight of the supernatant to obtain the cactus extract;
fucus vesiculosus extract: and (3) setting the fermentation bacterium liquid IV, honey and the fucus vesiculosus filtrate to be 5-20 mL: 20-50 g: selecting raw materials according to the proportion of 100-300g, uniformly mixing, placing the prepared solution in an environment of 25-30 ℃ for fermentation for 5-10 days, centrifuging for 15-30min at 8000-10000r/min, taking supernatant, adding activated carbon accounting for 3% of the weight of the supernatant, decoloring for 40min at 80 ℃, collecting decolored liquid, and concentrating to obtain 1/5 of the weight of the supernatant, namely the fucus extract;
(3) blending: and (3) mixing the extracts prepared in the step (2) according to the proportion of the composition with the moisturizing and relieving effects, uniformly stirring, and sterilizing to obtain the composition.
6. The method for preparing a composition with moisturizing and soothing effects according to claim 5, wherein the filtrate obtained in the step (1) is prepared by the following steps:
the specific preparation steps of the filtrate in the step (1) are as follows:
oat filtrate: sieving oat after impurity removal and crushing by a sieve of 80-200 meshes to obtain oat powder, and sieving by using amylase: oat flour: deionized water 0.001 g: 10-30 g: preparing solution by using 100-300mL, performing enzymolysis on the solution at the temperature of 32-38 ℃ and under the condition of pH value of 5.8-6.2 for 40-60min, and filtering to obtain filtrate for later use;
white fungus filtrate: sieving the tremella subjected to impurity removal and crushing by a sieve of 80 meshes, and mixing the tremella powder: deionized water is 1: 20-1: 40 taking materials, adding the tremella powder into deionized water, mixing and pulping, collecting pulp, adding pectinase accounting for 0.03-0.06% of the weight of the pulp into the pulp, carrying out enzymolysis for 2-4h at 35-38 ℃, and sieving by a 200-mesh sieve to obtain filtrate for later use;
cactus filtrate: cleaning radix et caulis Opuntiae Dillenii, removing spine and skin, cutting mesophyll, homogenizing with a homogenizer for 1-3min, filtering, and collecting filtrate;
fucus vesiculosus filtrate: cutting the rehydrated dried Fucus vesiculosus into pieces, adding deionized water according to the weight ratio of the feed liquid of 1:5-1:10, mixing and pulping, collecting the pulp, adding food grade pectase accounting for 0.03-0.06% of the weight of the pulp, performing enzymolysis at 35-38 ℃ for 1-3h, filtering with 200-mesh gauze, and taking the filtrate for later use.
7. Use of the composition with moisturizing and soothing effects according to any one of claims 1 to 4 or the composition with moisturizing and soothing effects prepared by the preparation method according to claim 5 or 6 in the preparation of cosmetics, wherein the composition with moisturizing and soothing effects is added in an amount of 0.05 to 1% by weight of the cosmetics.
8. Use of a composition with moisturizing and soothing effects according to claim 7, characterized in that the composition with moisturizing and soothing effects is contained in the cosmetic in an amount of 0.1-0.5% by weight of the cosmetic.
9. Use of the composition with moisturizing and soothing effects according to claim 8, wherein the cosmetic comprises at least one of a lotion, an essence, a cream, a mask, a cleanser or a BB cream.
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| CN112972354A (en) * | 2021-02-26 | 2021-06-18 | 广东梵蜜琳生物科技有限公司 | Skin care composition and application thereof in cosmetics |
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