JP4495406B2 - Sendangusa plant extract-containing composition - Google Patents
Sendangusa plant extract-containing composition Download PDFInfo
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- JP4495406B2 JP4495406B2 JP2003115703A JP2003115703A JP4495406B2 JP 4495406 B2 JP4495406 B2 JP 4495406B2 JP 2003115703 A JP2003115703 A JP 2003115703A JP 2003115703 A JP2003115703 A JP 2003115703A JP 4495406 B2 JP4495406 B2 JP 4495406B2
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- dermatitis
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- 239000000203 mixture Substances 0.000 title claims description 52
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
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- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明はセンダングサ属植物、特にビデンス・ピローサ抽出物を含む組成物及び抽出物の製造方法に関する。
【０００２】
【従来の技術】
ビデンス・ピローサは昔から身近にあるハーブであり、民間薬草として干した地上部分を煎じ、解熱・解毒・消炎・鎮痛・止瀉・利尿薬として肝炎・腎炎・盲腸炎・糖尿病・膀胱炎・尿道炎・リウマチ性関節炎・気管支炎・腫れ物・胃腸病・下痢・消化不良などに内用し、外用では咽喉の腫れや痛み、打撲傷などに用いられてきた。特に、盲腸炎には癒着のある重症のものでも、煎じ汁を飲むか、新芽をそのまま食べ、或いは60ｇほどを搗いて汁を飲む（蜜とか食塩を少々加えてもいい）と炎症も痛みも収まるとされている。また、腫れた咽喉の痛みには飲むと同時にうがい薬として使用することもよいとされている。また、多少の殺菌静菌作用もあるため打撲などの外傷や、腫れた所を洗ったり、局所に塗ったりなど外用薬としても使われてきた。
従来、ビデンス・ピローサの使用方法としては、内服用または外用として水で抽出したもの（煎じられたもの）が用いられてきた。例えば、生の植物10〜15ｇを水400ｍＬで煎じて半量まで煮詰めて飲むなどの方法がある。なお、ビデンス・ピローサは台湾では家庭用民間薬として、日本におけるドクダミやゲンノショウコなどのように野生のものを摘んで使用する人も多い。また中医（漢方医）の使う薬屋では調剤用咸豊草抽出物粉末が入手できる。花は黄色もあるが薬用には白色が良いとされている。
ビデンス・ピローサの成分研究の目的では、水抽出またはメタノールやエタノール等の溶媒による抽出が行われている（例えば非特許文献１参照）が、ビデンス・ピローサに他の添加物を添加して抽出を行った例は知られていない。
【０００３】
【非特許文献１】
Paul V. Tan et al., Journal of Ethnopharmacology 73, 415 (2000)
【０００４】
【発明が解決しようとする課題】
本発明は、センダングサ属植物の有用性、有効性を更に高めるセンダングサ属植物の抽出物を製造する方法及び前記抽出物を含む組成物を提供することを目的とする。
【０００５】
【課題を解決するための手段】
本発明者はセンダングサ属植物につき種々検討を重ねた結果、ショウガまたはウコン等のショウガ科植物を予めセンダングサ属植物に混合して抽出した抽出物を含む組成物が、センダングサ属植物単独で抽出したものよりも高血糖、皮膚炎、花粉症等の治療及び予防において、また美肌剤や日焼け止め等の化粧品として優れた効果を示すことを発見した。また、センダングサ属植物とショウガ科植物を混合したものを抽出した抽出物の方がそれぞれ単独で抽出したものを混合するよりも優れた効果、すなわち相乗効果を示すことを見出した。
すなわち本発明は、センダングサ属植物にショウガ科植物を混合して抽出溶媒にて抽出することにより製造されたセンダングサ属植物抽出物を含む組成物を提供するものである。
本発明はまた、センダングサ属植物にショウガ科植物を混合して抽出溶媒により抽出することを特徴とするセンダングサ属植物抽出物の製造方法を提供するものである。
【０００６】
【発明の実施の形態】
本発明に使用されるセンダングサ属植物は、特開２００１−１７８３９１号公報および特開２００１−２３３４２７号公報に記載されるように、学名ではビデンス（Bidens）属と言われる一群の植物である。種類も多岐に亘り互いに交配するので変種も多く、植物学上も混乱が見られ、学名、和名、漢名、の対応も交錯していて同定することは極めて困難であるが、本発明で用いられるセンダングサ属植物は以下に掲げるものを包含する。
【０００７】
Bidens pilosa L.（コセンダングサ、コシロノセンダングサ、咸豊草）
Bidens pilosa L .var. minor (Blume)Sherff （シロバナセンダングサ、シロノセンダングサ、コシロノセンダングサ、コセンダングサ、咸豊草）
Bidens pilosa L. var. bisetosa Ohtani et S.Suzuki（アワユキセンダングサ）
Bidens pilosa L. f. decumbens Scherff （ハイアワユキセンダングサ）
Bidens pilosa L. var. radiata Scherff （タチアワユキセンダングサ、ハイアワユキセンダングサを含むこともある）
Bidens pilosa L. var. radiata Schultz Bipontinus （シロノセンダングサ、オオバナノセンダングサ）
Bidens biternata Lour. Merrill et Sherff（センダングサ）
Bidens bipinnata L.（コバノセンダングサ、センダングサ）
Bidens cernua L.（ヤナギタウコギ）
Bidens frondosa L.（アメリカセンダングサ、セイタカタウコギ）
Bidens parviflora Willd （ホソバノセンダングサ）
Bidens radiata Thuill. var. pinnatifida (Turcz.)Kitamura（エゾノタウコギ）
Bidens tripartita L.（タウコギ）
【０００８】
上記センダングサ属植物の中で、特にビデンス・ピローサ（Bidens pilosa）類が好ましい。
上記センダングサ属植物は通常、生の植物を天日乾燥または熱風（例えば７０〜８０℃）乾燥したもの、又は蒸気で、例えば１時間〜１時間半程度蒸した後、乾燥したものを使用してもよい。
上記センダングサ属植物の使用部位は、根、地上部（茎、葉、花等）又は全草何れの部位を用いてもよい。特に、葉及び茎の部分を使用することが効力の点において好ましい。
【０００９】
ショウガ科植物としては、各種のショウガ、ウコン等が挙げられる。食用、薬用等に用いられるものでもよい。ショウガ科植物は、乾燥または粉砕された市販品を用いてもよく、または栽培した植物を乾燥して粉砕、若しくは蒸煮した後乾燥して粉砕したものを用いてもよい。ショウガ科植物の使用部位は少なくとも根を含む部分である。根部分のみを用いてもよく、または根と茎、葉等その他の部分を用いてもよい。本発明の効果の上で特に好ましいのは根の部分である。
【００１０】
本発明の抽出物製造方法において、上述したセンダングサ属植物、ショウガ科植物の他にさらに風味改善等の目的で他の植物を加えてもよい。他の植物としてはセンダングサ属植物、ショウガ科植物からの成分の抽出を阻害しないもの、また本発明の抽出物の効果を阻害しないものであればよい。具体的には、大麦等が挙げられる。大麦は特に風味の改善の目的で用いることができ、その場合には焙煎した大麦を用いることがさらに好ましい。大麦等を添加する場合には、ショウガ科植物に続いてセンダングサ属植物に添加し、その後抽出を行ってもよい。また、別途水等で抽出したものを本発明の方法により製造されたセンダングサ属植物抽出物に添加してもよい。
センダングサ属植物及びショウガ科植物以外の植物を添加する場合の混合比率は、センダングサ属植物乾燥重量に対して、乾燥重量基準で１０〜４００質量％である。
【００１１】
また、本発明の抽出物製造方法においてさらに酸化防止の目的で他の成分または植物を加えてもよい。他の成分または植物として具体的にはアセロラ抽出物またはアセロラが挙げられる。このような成分または植物を添加する場合には、ショウガ科植物に続いてセンダングサ属植物に添加してもよく、また、抽出後に添加してもよい。このような成分は、センダングサ属植物乾燥重量に対して、乾燥重量基準で１〜５０質量％添加してもよい。
【００１２】
本発明の方法は、センダングサ属植物にショウガ科植物を混合して抽出溶媒により抽出することを特徴とする。
本発明の方法の一つの実施態様を示すと、上述したようにセンダングサ属植物を乾燥したもの又は蒸気で蒸した後乾燥したものに対して、乾燥または蒸気で蒸した後乾燥し、粉砕したショウガ科植物を添加し、常温又は加温下に、溶媒を添加して抽出する。抽出方法としては例えば、浸漬して静置、またはソックスレー抽出器等の抽出器具を用いて抽出物を得ることもできる。
【００１３】
センダングサ属植物に対するショウガ科植物の混合比率は、センダングサ属植物の乾燥全重量に対してショウガ科植物が乾燥重量基準で０.０１〜２０質量％であることが好ましく、より好ましくは０.１〜５質量％である。ショウガ科植物の量が多くなりすぎるとショウガ科植物により皮膚に過剰な刺激を与えたり、ショウガ科植物の独特の風味が強くなりすぎるからであり、また少なすぎると本発明の効果が十分に得られないからである。
【００１４】
抽出に使用される溶媒の例としては、水、メタノール、エタノール、プロパノール、ブタノール、エチレングリコール、プロパンジオール、ブタンジオール、グリセリン等のアルコール類、並びにこれらの含水物、アセトン、エチルメチルケトン、クロロホルム、塩化メチレン及び酢酸エチル、並びにそれらの含水物を用いてもよい。また、上記溶媒を二種以上含む混合物であってもよい。溶媒の添加量は、例えば用いる植物の合計乾燥重量１ｋｇに対して１Ｌ〜１００Ｌ程度使用することができる。
抽出時の温度は、通常、室温〜沸点程度で行うことができる。また、抽出時間は、温度や溶媒にもよるが、室温〜沸点程度で抽出を行う場合には、１〜３００時間程度の範囲にわたって行うことができる。
【００１５】
抽出液は必要により溶媒を留去濃縮して濃縮物または固形物（乾燥物）としてもよい。濃縮物として使用する場合、濃度を調整した後そのまま用いてもよい。また、抽出物は、脱色、不用物除去のため活性炭処理、ＨＰ20等の樹脂処理、低温放置、瀘過等の処理を施してから用いてもよい。さらに当該抽出物を適当な分離手段、例えばゲル瀘過法やシリカゲルカラムクロマト法、又は逆相若しくは順相の高速液体クロマト法により活性の高い画分を分画して用いることもできる。
【００１６】
抽出物はそのまま、あるいは濃縮物または固形物（例えば粉末）として、内服または外用として用いてもよい。また、抽出物、抽出物の濃縮物または固形物は、水又は水−低級アルコール等の溶媒に溶解してもよい。また使用目的に応じて他の成分を混合して使用してもよい。
【００１７】
本発明の組成物としては、高血糖治療剤または高血糖予防剤、皮膚炎治療剤または皮膚炎予防剤、花粉症治療剤または花粉症予防剤、化粧品等が挙げられる。本発明のセンダングサ属植物抽出物を含む組成物は、高血糖改善作用を示し、高血糖治療剤または高血糖予防剤として用いることができる。また、本発明のセンダングサ属植物抽出物を含む組成物は高血糖改善作用を示す機能性食品としても有用である。高血糖治療剤または高血糖予防剤として用いる場合には、組成物の全重量に対して抽出物の乾燥重量換算で通常０．０１〜２０質量％程度の量が配合される。
【００１８】
本発明のセンダングサ属植物抽出物を含む組成物は、皮膚炎の改善作用を示し、皮膚炎治療剤または皮膚炎予防剤として用いることができる。用いることができる皮膚炎としては、アレルギー性皮膚炎、アトピー性皮膚炎、湿疹、接触皮膚炎等が挙げられる。また、本発明のセンダングサ属植物抽出物を含む組成物は皮膚炎改善作用を示す機能性食品としても有用である。皮膚炎治療剤または皮膚炎予防剤として用いる場合には、組成物の全重量に対して抽出物の乾燥重量換算で通常０．０１〜２０質量％程度の量が配合される。
【００１９】
本発明のセンダングサ属植物抽出物を含む組成物は、花粉症の改善作用を示し、花粉症治療剤または花粉症予防剤として用いることができる。用いることができる花粉症としては、杉花粉症、檜花粉症、カモガヤ花粉症等が挙げられる。また、本発明のセンダングサ属植物抽出物を含む組成物は皮膚炎改善作用を示す機能性食品としても有用である。皮膚炎治療剤または皮膚炎予防剤として用いる場合には、組成物の全重量に対して抽出物の乾燥重量換算で通常０．０１〜２０質量％程度の量が配合される。
【００２０】
本発明のセンダングサ属植物抽出物を含む組成物は、化粧品としても用いることができる。すなわち、内服若しくは外用により皮膚の保湿作用に効果があり、美肌剤等として使用することができる。また、日焼け止め作用も顕著であり、日焼け止めクリーム等の化粧品としても使用することができる。また、本発明のセンダングサ属植物抽出物を含む組成物は美肌作用を示す機能性食品としても有用である。化粧品が、美肌剤、または日焼け止め剤である場合、化粧品中に化粧品の全重量に対して抽出物の乾燥重量換算で通常は１０質量％程度以下、好ましくは１〜５質量％の量が配合される。化粧品として用いる場合には、化粧水、乳液、クリーム、パック等いずれの形態で用いても構わない。
【００２１】
以下試験例および実施例により本発明を具体的に説明するが、本発明はこれらに限定されるものではない。
【実施例】
（実施例１）内服による高血糖改善作用
ビデンス・ピローサ（タチアワユキセンダングサ）を流水で洗浄して異物を取り除いた後、数センチ程度に裁断した。裁断物を底が網状の円筒形容器に入れ、１時間〜１時間半程度蒸気で蒸煮した。その後ニーダーで圧潰し、７０〜８０℃程度の熱風で乾燥した（参照、特開平２００１−１７８３９０号公報）。
得られた乾燥物を、Ａ）ビデンス・ピローサ単独、Ｂ)ビデンス・ピローサとショウガとの混合物、およびＣ)ビデンス・ピローサとウコンとの混合物とし、さらにそれぞれを焙煎した大麦で倍散して、各３ｇをティーバッグに仕立てた。このティーバッグ１個に約１.２ Ｌの水を加えて５分間煮沸抽出し、その全量を１日で飲んでもらい、これを３カ月間毎日行った。調製したティーバッグの種類と内容は表１の通りである。
【００２２】
【表１】
ティーバッグの組成（質量％）
【００２３】
【表２】
高血糖者の空腹時血糖値（mg／dL）の変化
【００２４】
上記表からわかるようにビデンス・ピローサ単独（Ａ）でも若干の血糖降下作用が認められるが、ショウガとの混合物の抽出物（例えばＣ、Ｄ、Ｅ）では個人差はあるもののいずれも血糖降下作用がより顕著に認められた。またウコンとの混合物の抽出物（例えば、Ｇ、Ｈ）についても血糖降下作用が認められた。
またビデンス・ピローサ単独では、独特の野草味、野草臭があって甚だ飲みにくいものであるが、これに少量のショウガ或いはウコンを配合するとこの臭味は著明に改善され格段に飲みやすいものになった。また、本実験で血糖降下作用の他の評価要因として、香味に関して言えば好みに個人差はあるもののショウガまたはウコンの配合量が１〜５％、特に１〜３％が飲みやすく、７％では些か飲みにくいことが分かった。
【００２５】
（実施例２）内服による小児皮膚炎の改善作用
次の４例は、医師の診察を受けアトピー性皮膚炎と診断されたが、医師からの処方による薬剤を使用せず、ビデンス・ピローサ抽出物を使用した例である。最初１カ月は実施例例１の組成Ａ（ビデンス・ピローサ単独）を飲ませたところ、改善され０る傾向が見られたものの一進一退であった。２カ月目から組成Ｃ（ビデンス・ピローサ＋ショウガ）またはＧ（ビデンス・ピローサ＋ウコン）に変更したところ、下記に示すようにいずれも著名な改善が見られた。この間に排便の回数も増え便の状態も改善された。
【００２６】
内服による小児皮膚炎の改善（組成ＣまたはＧに変更後）
Ｋ子（３カ月女） 組成Ｃ使用
発症部位：顔・耳・頸の周囲、四肢の付根や関節部。
投与法：入浴前後毎回50〜60mL、授乳前毎回30〜40mL。
１日量：約10回、約400mL。
経過：１カ月で顔・耳、２カ月で頸の症状消退、３〜４カ月でほぼ完治
【００２７】
Ｎ子（４カ月女） 組成Ｇ使用
発症部位：耳・頸・頬・腕の関節部。
投与法：就眠前・授乳前毎回30〜60mL。
１日量：約10回、約500mL。
経過：約２週間でまず頬が、約５週間で他の部位の症状もほとんど消失した。
【００２８】
Ｓ子（１歳半女） 組成Ｃ使用
発症部位：手・腕・顔・ふくらはぎ。
投与法：随時。
１日量：10回以上、１〜1.2 Ｌ。
経過：約1.5カ月で顔の発疹が、他は１〜２カ月遅れ消失、その後半年再発なし。
【００２９】
Ｔ夫（２歳半男） 組成Ｃ使用
発症部位：耳・頸・腕・膝の裏。
投与法：随時。
１日量：10回以上、1.5 〜1.8Ｌ。
経過：約２カ月で発疹も痒みも次第に消退し３カ月で完治、その後半年再発なし。
【００３０】
結果を総合するとショウガやウコンを混合していない組成Ａを使用した期間は一進一退であったが、本発明の組成ＣまたはＧに変更してからは症状が顕著に改善された。
【００３１】
（実施例３）内服によるアトピー性皮膚炎の改善
42歳女性、20歳の時から顔面〜頸・胸にかけても重症のアトピー性皮膚炎が出て長期間ステロイド剤を使用していた。平成14年11月からステロイド剤を止めて、試験例１の組成Ａ（ビデンス・ピローサ単独）を１日２〜2.5Ｌ飲んだところ１カ月頃から少し改善が見られ始めたが４カ月に入った頃にやや逆戻りしたので、本発明の組成Ｂ（ビデンス・ピローサ＋ショウガ）に変更したところ、通算約７カ月で皮膚の色素斑もほとんど消え、一見して分からないくらいに改善が認められた。
【００３２】
（実施例４）内服による主婦湿疹の改善
48歳女性、約２年前に洗剤で手が荒れた時から、四肢の主として外側に広範囲に、皮膚の隆起と硬化を伴い色素斑を残す皮膚炎を発症、病院でステロイド外用剤の投与を受け却って増悪した。平成13年２月からステロイド剤を止めて試験例１の組成Ａ（ビデンス・ピローサ単独）のティーバッグを１日約３Ｌ（２包分）を飲んだところ、約２カ月で炎症はやや治まる傾向が見えたが別の箇所に新たな発症が見られたので、本発明の組成Ｄ（ビデンス・ピローサ＋ショウガ）に変更したところ次第に改善されて色素斑や皮膚の隆起も退縮し、通算約５カ月でほぼ全快に近い状態となった。
【００３３】
（実施例５）内服による夏季潰瘍の改善
皮膚の毛細血管の血行が障害されて膝から下の足、特に関節付近の皮膚に疼痛を伴う潰瘍を生じ、春から夏になると再発しやすい夏季潰瘍と呼ばれる特に女性に多く報告されている難病がある。そのような患者７人に実施例１のＣ（ビデンス・ピローサ＋ショウガ）を試みに飲んでもらった（早い人は平成12年５月下旬から、遅い人は７月下旬から、１日１包、１〜1.2Ｌ）ところ、その夏は７人全員に潰瘍の再発が見られなかった。この時点で再発率ゼロ、そして飲まなかった９人中５人、関連病院の13例中９人が再発した。そこで翌13年３月から本発明以前の単純な組成のＡ（ビデンス・ピローサ単独）に変更したところ３人に潰瘍が再発し、内１人は軽症であったが２人はかなり重症で、再び本発明の組成Ｃに戻して軽症の１人は軽快したが重症の２人は改善せず、翌14年６月になって漸く潰瘍の新生は見られなくなった。症例を逐次追加し14年の夏は最初の７人を含めて15人中13人が再発しなかった。組成Ａを使用した時期の潰瘍の数、大きさ、程度などを含めた観察結果から組成Ｃは明らかに組成Ａよりも有効性が優れていた。
【００３４】
（実施例６）ビデンス・ピローサ抽出条件の違いによる抗炎症作用比較試験
実施例１〜５において、内服剤としてビデンス・ピローサ単味よりも少量のショウガやウコンを配合して煎じたものの方がより有効であることが見出されたが、この理由として、a)ショウガやウコンの作用が、ビデンス・ピローサの作用に単に付加されたか、b)ショウガやウコンの添加によってビデンス・ピローサの作用が相乗的に増強されたことが考えられる。一方、実施例１に示したような血糖降下作用はショウガやウコンには報告されておらず、a)の解釈は成立しにくい。これを確認すため抗炎症作用を代表として選び、ヒトでのパッチテストを行った。
【００３５】
［抽出条件］
ビデンス・ピローサ水：実施例１と同じ材料100ｇに精製水２Ｌを加え、90〜100℃で５時間抽出した後、濾紙を用いて濾過し、瀘液を濃縮して抽出物全量を100mLとした。
ショウガ水：乾燥ショウガ粉末100ｇをビデンス・ピローサと同様に処理して抽出物全量を100mLとした。
ウコン水：乾燥ウコン粉末も同様に処理した。
混合抽出物１：ビデンス・ピローサ94ｇ＋ショウガ６ｇを同様に処理した。
混合抽出物２：ビデンス・ピローサ94ｇ＋ウコン６ｇを同様に処理した。
【００３６】
［パッチテスト試料］
試料１：ビデンス・ピローサ水単独
試料２：ビデンス・ピローサ水94部＋ショウガ水６部の混液
試料３：ビデンス・ピローサ水94部＋ウコン水６部の混液
試料４：混合抽出物１
試料５：混合抽出物２
【００３７】
［消炎効果の比較試験］
1）接触皮膚炎治療効果
起炎剤（ラウリル硫酸ナトリウムの10％水溶液）を上腕内側に４時間クローズドパッチし、90分後、試料（0.5mL）を16時間クローズドパッチして120時間まで観察した結果は表３に示すとおりである。
【００３８】
【表３】
消炎効果の比較試験
【００３９】
2）接触皮膚炎予防効果
起炎剤を試料に混合して上腕内側に５時間クローズドパッチし、72時間まで観察した。その結果は表４に示すとおりである。
【００４０】
【表４】
炎症抑制効果の比較試験
【００４１】
（実施例７）美肌用スキンクリームの効果
実施例６で調製した試料を用いて表５に示す組成のスキンクリームを調製し、その効果及び使用感について、下記の方法に従い評価を行った。
［製造方法］
表５のＡグループ成分を加温溶解し80℃に保った油相に、Ｂグループ成分を同様に処理した水相を加えて乳化し、冷却して製品（スキンクリーム１〜３）とした。
［評価方法］
上述したように製造した製品を、製品１ｇ／日の使用量で、各クリームについて２０名づつの被験者の顔と手に塗布して、１ヶ月間使用することにより評価した。
【００４２】
［評価基準］
【００４３】
【表５】
美肌用スキンクリームの比較評価
*2：スキンクリーム２（本発明）
*3：スキンクリーム３（本発明）
【００４４】
表５のとおり、対照である従来法のビデンス・ピローサ水を混合したスキンクリーム１に比べて本発明の混合抽出物１及び２を添加したスキンクリーム２及び３の方が顕著な美肌効果及び使用感の改善が認められた。またカブレを訴えた者は全くいなかった。
【００４５】
（実施例８）乳液によるアトピー性皮膚炎の軽減
実施例１と同じビデンス・ピローサ94ｇにショウガ６ｇを混合し、エタノール２Ｌを加え、常温で７日間抽出した後、瀘液を濃縮して抽出物全量を100mLとして、混合抽出物３を製造した。また別にエタノールの代りに1,3-ブチレングリコールを用いて、混合抽出物４を製造した。対照としてビデンス・ピローサ100ｇをエタノールまたは1,3-ブチレングリコールで同様に処理したもの（ビデンス・ピローサ＋エタノール、及びビデンス・ピローサ＋1,3-ブチレングリコール）を用意した。
［乳液の製造方法］
表６のＡグループ成分を加温溶解し80℃に保った油相に、Ｂグループ成分を同様に処理した水相を加えて乳化し、冷却して製品（乳液１〜４）とした。
【００４６】
［評価方法］
これらの抽出物を配合した表６に示す組成の乳液を用い、アトピー性皮膚炎患者（全１０名）で評価を行った。アトピー性皮膚炎が発症した部位に、０．５g/cm2程度の使用量で、１ヶ月間使用した。その効果及び使用感につき下記の方法に従い評価を行った。
［評価基準］
【表６】
乳液によるアトピー性皮膚炎の改善
表６の結果に見られるように、エタノールで抽出した場合も1,3-ブチレングリコールで抽出した場合も本発明の実施例（混合抽出物３及び４）の方が比較（ビデンス・ピローサ＋エタノール、ビデンス・ピローサ＋1,3-ブチレングリコール）に比べて、顕著な消炎効果と、カユミ止め効果の改善が認められた。
【００４９】
（実施例９）日焼け止めクリームの効果の改善
［日焼け止めクリームの製造方法］
表７の成分Ａグループを加温溶解し80℃に保った油相に、成分Ｂグループを同様に処理した水相を加えて乳化し、冷却して製品（日焼け止めクリーム１〜４）とした。なお、表７における混合抽出物３、混合抽出物４、ビデンス・ピローサ＋エタノール、及びビデンス・ピローサ＋1,3-ブチレングリコールは、実施例８において調整したものと同じである。
[評価方法]
得られて製品を人の背部に塗布しその上に紫外線ＵＶＢを照射し、日本化粧品工業会の測定法に準じ日焼け防止効果ＳＰＦを算出して評価を行った。
【００５０】
【表７】
日焼け止めクリームの効果の改善
*2：日焼け止めクリーム２（本発明）
*3：日焼け止めクリーム３（比較例）
*3：日焼け止めクリーム４（本発明）
【００５１】
表７の結果に見られるように、エタノールで抽出した場合も1,3-ブチレングリコールで抽出した場合も本発明の実施例（混合抽出物３及び４）の方が比較（ビデンス・ピローサ＋エタノール、ビデンス・ピローサ＋1,3-ブチレングリコール）に比べて、顕著な日焼け防止効果の改善が見られた。
【００５２】
（実施例１０）
タチアワユキセンダングサの地上部を刈り取り洗浄後、適当な長さに刻んで約１時間蒸煮し、80℃の熱風を送って通風乾燥した。その10kgに、乾燥したショウガ3kgを添加して、水／メタノール／1,3-ブチレングリコール（1/1/2、v/v）混液200Ｌを加えて室温で1週間放置して抽出し、濾過を行い、濾紙上の不溶物を十分に絞って濾液を得た。得られた濾液に乳糖0.5kgを加えて噴霧乾燥し、2.9kgの抽出物粉末を得た。
この抽出物粉末に賦形剤としてアビセル（結晶セルロース）0.3kgと滑沢剤として蔗糖脂肪酸エステル0.1kgを加え、打錠して250mgの錠子とした。
【００５３】
杉花粉症に対する効果
くしゃみ、鼻水、目のかゆみ等の症状を有する杉花粉症患者５人を被験者とした。５人とも、医師の指導のもと、抗アレルギー剤、マスクの着用等の措置を講じていたが依然として症状が緩和されなかった。この５人の被験者に、医者の薬を止めて本発明の錠子を空腹時に３錠ずつ１日３回飲んでもらったところ、いずれも以下に示すように10日以内にはすっきりと症状がなくなった。その後服用を継続している限り症状が出なかったが、服用を二三日忘れると発症した。
【００５４】
１）Ｙ．Ｓ．男性47歳（会社管理職）5〜7日でほとんど症状がなくなり、その後再発症しなかった。
２）Ｓ．Ｔ．男性39歳（会社営業職）約1週間で症状が非常に軽くなった。
３）Ｋ．Ｉ．男性44歳（地方公務員）4〜5日でほとんど症状がなくなり、その後再発症しなかった。
４）Ｍ．Ｉ．男性75歳（会社役員）数日後からほとんど花粉症の症状が無くなった。
５）Ｒ．Ｉ．女性39歳（会社事務職）10日ほど経ってから極めて症状が軽くなった。
【発明の効果】
以上の通り、本発明の方法により得られた抽出物を含む組成物は、高血糖、皮膚炎、花粉症等の治療及び予防剤として、また美肌剤や日焼け止め等の化粧品として優れた効果を示し、さらにビデンス・ピローサ単独の抽出物より明らかに優れた効果を示す。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a composition containing Sendangusa plants, in particular, a Bidence pirosa extract, and a method for producing the extract.
[0002]
[Prior art]
Bidence Pilosa is a herb that has been around for a long time, decoction of dried ground as a private medicinal herb, hepatitis, nephritis, cecalitis, diabetes, cystitis, urethritis as antipyretic, detoxification, anti-inflammatory, analgesic, antipruritic, diuretic・ It has been used internally for rheumatoid arthritis, bronchitis, swelling, gastrointestinal disease, diarrhea, indigestion, etc., and for external use it has been used for swelling, pain, and bruises in the throat. In particular, even in severe cases with adhesions, if you drink decoction juice, eat shoots as it is, or drink about 60 g of juice (you can add a little nectar or salt), inflammation and pain will subside. It is said that. For swollen sore throat, it can be used as a mouthwash at the same time as drinking. In addition, since it has some bacteriostatic bacteriostatic action, it has been used as a topical medicine for trauma such as bruises, washing swollen areas, and applying it locally.
Conventionally, as a method of using Bidence Pilosa, one extracted with water for internal use or external use (decoction) has been used. For example, there is a method in which 10 to 15 g of a raw plant is decocted with 400 mL of water, half-boiled and then drunk. Bidence Pilosa is often used in Taiwan as a home folk medicine by picking wild things such as Japanese dolphin and Genkosho. In addition, you can obtain powdered licorice herb extract powder at a drugstore used by a Chinese doctor. Flowers are yellow, but white is considered good for medicinal purposes.
For the purpose of studying the components of Bidence pillows, water extraction or extraction with a solvent such as methanol or ethanol is performed (for example, see Non-Patent Document 1), but extraction is performed by adding other additives to Bidence Pilosa. No example has been done.
[0003]
[Non-Patent Document 1]
Paul V. Tan et al., Journal of Ethnopharmacology 73, 415 (2000)
[0004]
[Problems to be solved by the invention]
An object of the present invention is to provide a method for producing an extract of the plant belonging to the genus Sendangusa that further enhances the usefulness and effectiveness of the plant belonging to the genus Sendangsa, and a composition containing the extract.
[0005]
[Means for Solving the Problems]
The present inventor has conducted various studies on Sendangusa plants, and as a result, a composition containing an extract obtained by previously mixing ginger family plants such as ginger or turmeric with Sendendusa plants and extracted by Sendangusa plants alone is extracted. It has been found that it has an excellent effect in the treatment and prevention of hyperglycemia, dermatitis, hay fever, etc., and as a cosmetic product such as a skin cleanser and sunscreen. In addition, the present inventors have found that an extract obtained by extracting a mixture of Sendangsa genus plants and ginger family plants exhibits a superior effect, that is, a synergistic effect, compared with a case where each extract is independently mixed.
That is, the present invention provides a composition comprising a Sendangusa plant extract produced by mixing a Ginger plant with a Sendangsa plant and extracting it with an extraction solvent.
The present invention also provides a method for producing an extract of the genus Sendanga, which comprises mixing a ginger family plant with the plant of the genus Sendangsa and extracting the extract with an extraction solvent.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
As described in Japanese Patent Application Laid-Open Nos. 2001-178391 and 2001-233427, the plants belonging to the genus Sendangsa used in the present invention are a group of plants referred to by the genus Bidens in scientific name. There are many varieties because they cross each other in a wide variety, and there is confusion in botany, and it is extremely difficult to identify because the correspondence between scientific names, Japanese names, and Han names is also mixed. The Sendangsa plants used include the following:
[0007]
Bidens pilosa L. (Kosendangusa, Koshirono Sendangusa, Sakai Toyokusa)
Bidens pilosa L .var. Minor (Blume) Sherff (Shirobanasendangusa, Shironosendangusa, Koshironosendangsa, Kosendangusa, Sagafengakusa)
Bidens pilosa L. var. Bisetosa Ohtani et S. Suzuki
Bidens pilosa L. f. Decumbens Scherff
Bidens pilosa L. var. Radiata Scherff (may also include Tachiawayukisendangusa, Hiawayukisendangusa)
Bidens pilosa L. var. Radiata Schultz Bipontinus (Shironosendangusa)
Bidens biternata Lour. Merrill et Sherff (Sendangsa)
Bidens bipinnata L. (Kobano Sendangsa, Sendangsa)
Bidens cernua L.
Bidens frondosa L. (American Sendangsa, Seitakatakogi)
Bidens parviflora Willd
Bidens radiata Thuill. Var. Pinnatifida (Turcz.) Kitamura
Bidens tripartita L.
[0008]
Among the above-mentioned plants of the genus Sendangsa, Bidens pilosa is particularly preferable.
The above-mentioned Sendangsa plant usually uses a raw plant obtained by drying in the sun or hot air (for example, 70 to 80 ° C.), or steaming, for example, steaming for about 1 hour to 1 and a half hours, and then drying the plant. Also good.
The use part of the above-mentioned Sendangsa plant may be any part of the root, the above-ground part (stem, leaf, flower, etc.) or the whole plant. In particular, the use of leaf and stem portions is preferred in terms of efficacy.
[0009]
Examples of ginger family plants include various ginger and turmeric. It may be used for food, medicine and the like. As the ginger plant, a commercially available product that has been dried or pulverized may be used, or a cultivated plant that has been dried and pulverized, or steamed and then dried and pulverized may be used. The use part of the ginger family plant is a part including at least a root. Only the root part may be used, or other parts such as roots and stems and leaves may be used. From the viewpoint of the effect of the present invention, the root portion is particularly preferable.
[0010]
In the method for producing an extract of the present invention, other plants may be added for the purpose of improving the flavor in addition to the above-mentioned Sendangsa genus plants and ginger family plants. Other plants may be those that do not inhibit the extraction of components from Sendangusa plants and ginger family plants, and those that do not inhibit the effect of the extract of the present invention. Specifically, barley etc. are mentioned. Barley can be used particularly for the purpose of improving the flavor, in which case roasted barley is more preferably used. When adding barley or the like, it may be added to the plant belonging to the genus Sendangsa following the ginger family plant and then extracted. Moreover, you may add what was separately extracted with water etc. to the Sendangusa genus plant extract manufactured by the method of this invention.
The mixing ratio in the case of adding a plant other than the Sendanga genus plant and the ginger family plant is 10 to 400% by mass on the dry weight basis with respect to the dry weight of the Sendangsa genus plant.
[0011]
Moreover, you may add another component or a plant in the extract manufacturing method of this invention further for the purpose of antioxidant. Specific examples of other components or plants include acerola extract or acerola. When such a component or plant is added, it may be added to a plant belonging to the genus Sendangusa following a ginger plant, or may be added after extraction. Such a component may be added in an amount of 1 to 50% by mass based on the dry weight with respect to the dry weight of the Sendangusa plant.
[0012]
The method of the present invention is characterized in that a ginger plant is mixed with a Sendangusa plant and extracted with an extraction solvent.
According to one embodiment of the method of the present invention, as described above, ginger that has been dried or steamed and then dried and crushed with respect to a dried plant of the genus Sendangsa or steamed and steamed A family plant is added and a solvent is added and extracted at room temperature or under heating. As an extraction method, for example, the extract can be obtained by immersing and standing, or using an extraction device such as a Soxhlet extractor.
[0013]
The mixing ratio of the ginger family plant relative to the plant of the genus Sendungusa is preferably 0.01 to 20% by mass, more preferably 0.1 to 20% by mass, based on the dry weight of the ginger family plant with respect to the total dry weight of the genus Sendangsa. 5% by mass. If the amount of the ginger plant is too large, the ginger plant will excessively irritate the skin, or the unique flavor of the ginger plant will be too strong. If the amount is too small, the effect of the present invention will be sufficiently obtained. Because it is not possible.
[0014]
Examples of solvents used for extraction include water, methanol, ethanol, propanol, butanol, ethylene glycol, propanediol, butanediol, glycerin and other alcohols, and their hydrates, acetone, ethyl methyl ketone, chloroform, Methylene chloride and ethyl acetate and their hydrates may be used. Moreover, the mixture containing 2 or more types of the said solvent may be sufficient. The amount of the solvent added can be, for example, about 1 L to 100 L with respect to 1 kg of the total dry weight of the plant to be used.
The temperature at the time of extraction can be normally performed at room temperature to about the boiling point. The extraction time depends on the temperature and the solvent, but when extraction is performed at room temperature to about boiling point, it can be performed over a range of about 1 to 300 hours.
[0015]
The extract may be concentrated or solid (dry product) by distilling off the solvent if necessary. When used as a concentrate, it may be used as it is after the concentration is adjusted. In addition, the extract may be used after being subjected to treatment such as activated carbon treatment, resin treatment such as HP20, low-temperature standing, filtration, etc. for decolorization and removal of waste. Further, the extract can be used by fractionating a highly active fraction by an appropriate separation means such as a gel filtration method, a silica gel column chromatography method, or a reversed phase or normal phase high performance liquid chromatography method.
[0016]
The extract may be used as it is or as a concentrate or solid (eg, powder) for internal use or external use. Further, the extract, the concentrate of the extract, or the solid may be dissolved in a solvent such as water or water-lower alcohol. Moreover, you may mix and use another component according to the intended purpose.
[0017]
Examples of the composition of the present invention include a hyperglycemic therapeutic agent or a hyperglycemic preventive agent, a dermatitis therapeutic agent or a dermatitis preventive agent, a hay fever therapeutic agent or a hay fever preventive agent, and cosmetics. The composition containing the plant extract of the genus Sendanga of the present invention exhibits an action for improving hyperglycemia and can be used as a therapeutic agent for hyperglycemia or a preventive agent for hyperglycemia. Moreover, the composition containing the Sendangusa genus plant extract of the present invention is useful as a functional food exhibiting an action for improving hyperglycemia. When used as an antihyperglycemic agent or an antihyperglycemic agent, an amount of about 0.01 to 20% by mass is usually added in terms of the dry weight of the extract with respect to the total weight of the composition.
[0018]
The composition containing the plant extract of the genus Sendanga of the present invention exhibits an effect of improving dermatitis and can be used as a dermatitis therapeutic agent or a dermatitis preventive agent. Examples of dermatitis that can be used include allergic dermatitis, atopic dermatitis, eczema, and contact dermatitis. Moreover, the composition containing the Sendangusa genus plant extract of this invention is useful also as a functional food which shows the dermatitis improvement effect. When used as a dermatitis therapeutic agent or dermatitis preventive agent, an amount of about 0.01 to 20% by mass in terms of the dry weight of the extract is usually blended with respect to the total weight of the composition.
[0019]
The composition containing the plant extract of the genus Sendanga of the present invention exhibits an action for improving hay fever and can be used as a hay fever therapeutic agent or a hay fever preventive agent. Examples of hay fever that can be used include cedar pollinosis, gonorrhoea, and hemlock hay fever. Moreover, the composition containing the Sendangusa genus plant extract of this invention is useful also as a functional food which shows the dermatitis improvement effect. When used as a dermatitis therapeutic agent or dermatitis preventive agent, an amount of about 0.01 to 20% by mass in terms of the dry weight of the extract is usually blended with respect to the total weight of the composition.
[0020]
The composition containing the Sendangusa plant extract of the present invention can also be used as a cosmetic. That is, it is effective for moisturizing the skin by internal use or external use, and can be used as a skin beautifier or the like. Moreover, the sunscreen action is also remarkable and it can be used as cosmetics such as sunscreen cream. Moreover, the composition containing the Sendangusa genus plant extract of this invention is useful also as a functional food which shows a beautifying skin effect. When the cosmetic is a skin beautifying agent or a sunscreen, the amount of the extract is usually about 10% by mass or less, preferably 1 to 5% by mass in terms of the dry weight of the extract with respect to the total weight of the cosmetic. Is done. When used as a cosmetic, it may be used in any form such as lotion, milky lotion, cream or pack.
[0021]
Hereinafter, the present invention will be specifically described with reference to test examples and examples, but the present invention is not limited thereto.
【Example】
(Example 1) Hyperglycemia improvement effect by internal use
Bidence Pilosa (Tachiawayukisendangusa) was washed with running water to remove foreign matter, and then cut into several centimeters. The cut material was put into a cylindrical container having a net-like bottom and steamed with steam for about 1 hour to 1 hour and a half. After that, it was crushed with a kneader and dried with hot air of about 70 to 80 ° C. (see JP-A-2001-178390).
The obtained dried product was made into A) a Bidence Pilosa alone, B) a mixture of Bidence Pilosa and ginger, and C) a mixture of Bidence Pilosa and Turmeric, and each was further triturated with roasted barley. Each 3 g was made into a tea bag. About 1.2 L of water was added to one tea bag, boiled and extracted for 5 minutes, and the whole amount was drunk in one day, and this was performed every day for three months. Table 1 shows the types and contents of the prepared tea bags.
[0022]
[Table 1]
Tea bag composition (% by mass)
[0023]
[Table 2]
Changes in fasting blood glucose level (mg / dL) in hyperglycemic patients
[0024]
As can be seen from the above table, a slight hypoglycemic effect is observed even with Bidence Pilosa alone (A), but the extract of a mixture with ginger (eg, C, D, E) has an individual hypoglycemic effect. Was more prominent. Moreover, the hypoglycemic effect was recognized also about the extract (for example, G, H) of the mixture with turmeric.
In addition, Bidence Pyrrosa alone has a unique wild herb taste and wild grass odor, and it is difficult to drink, but when added with a small amount of ginger or turmeric, this odor is markedly improved and much easier to drink. became. As another evaluation factor of hypoglycemic action in this experiment, although there are individual differences in tastes, the amount of ginger or turmeric is 1 to 5%, especially 1 to 3% is easy to drink, and 7% I found it a little difficult to drink.
[0025]
(Example 2) Improvement of childhood dermatitis by internal use
The following four cases are cases in which atopic dermatitis was diagnosed after consulting with a doctor, but a medicine based on the prescription from the doctor was not used but a Bidence Pilosa extract was used. In the first month, when the composition A of Example 1 (Bidence Pyrrosa alone) was drunk, there was a tendency to improve, but it was a retreat. When the composition was changed from the second month to composition C (vidence pilosa + ginger) or G (vidence pilosa + turmeric), as shown below, both markedly improved. During this time, the number of defecations increased and the condition of the stool improved.
[0026]
Improvement of pediatric dermatitis by internal use (after changing to composition C or G)
K child (3 months female) Composition C used
Site of onset: Around the face, ears and neck, roots and joints of the extremities.
Administration method: 50-60 mL each time before and after bathing, 30-40 mL each time before breastfeeding.
Daily dose: about 10 times, about 400 mL.
Course: Face and ear in 1 month, neck symptoms disappeared in 2 months, almost cured in 3-4 months
[0027]
N child (4 months female) Composition G used
Onset site: Ear, neck, cheek, arm joint.
Administration method: 30-60 mL each time before going to sleep and before breastfeeding.
Daily dose: about 10 times, about 500 mL.
Progress: The cheeks first disappeared in about 2 weeks, and symptoms in other parts almost disappeared in about 5 weeks.
[0028]
S child (1 and a half years old woman) Use composition C
Onset site: hands, arms, face, calf.
Administration method: As needed.
Daily dose: 10 times or more, 1-1.2 L.
Progress: Facial rash in about 1.5 months, others disappeared after 1-2 months, and there was no recurrence in the latter half of the year.
[0029]
T husband (2 and a half years old) Composition C used
Onset site: Ear, neck, arm, back of knee.
Administration method: As needed.
Daily dose: 10 times or more, 1.5-1.8L.
Progress: The rash and itching gradually disappeared in about 2 months, and it was completely cured in 3 months.
[0030]
To summarize the results, the period when the composition A containing no ginger or turmeric was used was once and again, but after changing to the composition C or G of the present invention, the symptoms were remarkably improved.
[0031]
(Example 3) Improvement of atopic dermatitis by internal use
A 42-year-old woman had been suffering from severe atopic dermatitis from the face to the neck and chest since the age of 20 and had been using steroids for a long time. Steroids were stopped in November 2002, and composition A of Test Example 1 (Bidence Pilosa alone) was drunk 2 to 2.5 liters a day. When it was changed back to composition B of the present invention (Bidence Pilosa + ginger), the pigment spots on the skin almost disappeared in about 7 months, and an improvement that was not apparent at first glance was observed. .
[0032]
(Example 4) Improvement of housewife eczema by internal use
A 48-year-old woman has developed dermatitis that leaves pigment spots with swelling and hardening of the skin, mainly on the outside of the extremities, since her hands were roughened with detergent about 2 years ago. Receiving and getting worse. In February 2001, when steroids were stopped and tea bags of Composition A (Bidence Pilosa alone) from Test Example 1 were taken about 3 liters (2 packs) per day, inflammation tends to subside somewhat in about 2 months. However, since a new onset was observed in another part, when it was changed to the composition D of the present invention (bidence pillowa + ginger), it gradually improved, and pigment spots and skin bulges also regressed. In almost a month, it was almost completely full.
[0033]
(Example 5) Improvement of summer ulcer by internal use
An intractable illness often reported to women, especially called summer ulcers, which causes painful ulcers in the legs below the knees, especially in the skin near the joints, due to impaired blood circulation of the skin's capillaries, and which tends to recur from spring to summer There is. Seven such patients were allowed to try the C (bidence pillowa + ginger) of Example 1 (the early one from late May 2000, the late one from the end of July, one packet per day) However, in the summer, no recurrence of ulcers was observed in all seven people. At this time, the recurrence rate was zero, and 5 out of 9 who did not drink and 9 out of 13 related hospitals relapsed. Therefore, from March 2013, when A was changed to simple composition A (Bidence Pilosa alone) prior to the present invention, ulcers recurred in three people, one of which was mild but two were quite severe. Returning to the composition C of the present invention again, one mild patient was relieved, but two serious patients did not improve, and in June 2014, ulcer formation was gradually disappeared. In the summer of 2014, 13 out of 15 cases, including the first seven, did not recur. From the observation results including the number, size, degree, etc. of ulcers at the time of using composition A, composition C was clearly superior to composition A in effectiveness.
[0034]
(Example 6) Comparative test of anti-inflammatory effect depending on the extraction conditions of evidence and pillows
In Examples 1 to 5, it was found that a decoction containing a small amount of ginger or turmeric was more effective as an internal medicine than a simple Bidence / Pirosa. It is considered that the action of turmeric or turmeric was simply added to the action of Bidence Pilosa, or b) the action of Bidence Pilosa was synergistically enhanced by the addition of ginger or turmeric. On the other hand, the hypoglycemic effect as shown in Example 1 has not been reported in ginger and turmeric, and interpretation of a) is difficult to achieve. In order to confirm this, an anti-inflammatory action was selected as a representative and a human patch test was performed.
[0035]
[Extraction condition]
Bidence Pilosa water: 2 g of purified water was added to 100 g of the same material as in Example 1 and extracted at 90-100 ° C. for 5 hours, followed by filtration using filter paper. The filtrate was concentrated to a total volume of 100 mL of extract. .
Ginger water: 100 g of dry ginger powder was treated in the same manner as Bidence Pilosa to make the total amount of extract 100 mL.
Turmeric water: Dry turmeric powder was treated in the same manner.
Mixed extract 1: 94 g of Bidence Pilosa + 6 g of ginger were treated in the same manner.
Mixed extract 2: 94 g of Bidence Pilosa + 6 g of turmeric were treated in the same manner.
[0036]
[Patch test sample]
Sample 1: Bidence Pilosa water alone
Sample 2: Mixed liquid of 94 parts of Bidence Pilosa water + 6 parts ginger water
Sample 3: A mixture of 94 parts of Bidence Pilosa water and 6 parts of Turmeric water
Sample 4: Mixed extract 1
Sample 5: Mixed extract 2
[0037]
[Comparison test of anti-inflammatory effect]
1) Contact dermatitis treatment effect
Table 3 shows the results of the observation of the flame retardant (10% aqueous solution of sodium lauryl sulfate) on the inner side of the upper arm for 4 hours, 90 minutes later, and the sample (0.5 mL) for 16 hours. It is.
[0038]
[Table 3]
Comparative test of anti-inflammatory effect
[0039]
2) Preventing contact dermatitis
The flame retardant was mixed with the sample and patched inside the upper arm for 5 hours and observed for up to 72 hours. The results are shown in Table 4.
[0040]
[Table 4]
Comparative study of anti-inflammatory effect
[0041]
(Example 7) Effect of skin cream for beautiful skin
A skin cream having the composition shown in Table 5 was prepared using the sample prepared in Example 6, and the effects and feeling of use were evaluated according to the following methods.
[Production method]
A water phase in which the B group component was treated in the same manner was added to the oil phase in which the A group component in Table 5 was dissolved by heating and maintained at 80 ° C. to emulsify and cool to obtain products (skin creams 1 to 3).
[Evaluation methods]
The product produced as described above was evaluated by applying it to the face and hands of 20 subjects for each cream at a usage rate of 1 g / day of the product and using it for one month.
[0042]
[Evaluation criteria]
[0043]
[Table 5]
Comparative evaluation of skin creams for beautiful skin
* 2 : Skin cream 2 (present invention)
* 3 : Skin cream 3 (present invention)
[0044]
As shown in Table 5, the skin creams 2 and 3 to which the mixed extracts 1 and 2 of the present invention were added as compared with the skin cream 1 to which the conventional Bidence / Pirosa water was mixed as a control, had a remarkable skin beautifying effect and use. Improvement of feeling was recognized. No one had sued Kabure.
[0045]
(Example 8) Reduction of atopic dermatitis by emulsion
6 g of ginger was mixed with 94 g of the same evidence pillow as in Example 1, 2 L of ethanol was added, and the mixture was extracted at room temperature for 7 days. Then, the filtrate was concentrated to make the total amount of the extract 100 mL, thereby producing a mixed extract 3. Separately, mixed extract 4 was produced using 1,3-butylene glycol instead of ethanol. As a control, 100 g of Bidence Pilosa treated with ethanol or 1,3-butylene glycol in the same manner (Bidens Pilosa + ethanol and Bidence Pilosa + 1,3-butylene glycol) was prepared.
[Method for producing emulsion]
A water phase in which the B group component was treated in the same manner was added to the oil phase in which the A group component in Table 6 was dissolved by heating and maintained at 80 ° C. to emulsify and cool to give products (milky lotions 1 to 4).
[0046]
[Evaluation methods]
Evaluation was carried out on patients with atopic dermatitis (total of 10 patients) using the emulsion having the composition shown in Table 6 containing these extracts. 0.5 g / cm at the site of atopic dermatitis 2 It was used for about 1 month with the amount used. The effect and usability were evaluated according to the following methods.
[Evaluation criteria]
[Table 6]
Improvement of atopic dermatitis by emulsion.
As can be seen from the results in Table 6, the examples of the present invention (mixed extracts 3 and 4) were compared with each other when extracted with ethanol and extracted with 1,3-butylene glycol (Bidence Pilosa + ethanol). , Bidence Pilosa + 1,3-butylene glycol), a marked anti-inflammatory effect and an improvement in the anti-fogging effect were observed.
[0049]
(Example 9) Improvement of the effect of sunscreen cream
[Production method of sunscreen cream]
To the oil phase in which the component A group in Table 7 was heated and dissolved and maintained at 80 ° C., a water phase similarly treated with the component B group was added to emulsify, and cooled to obtain products (sunscreen creams 1 to 4). . In Table 7, the mixed extract 3, mixed extract 4, Bidence Pilosa + ethanol, and Bidence Pilosa + 1,3-butylene glycol are the same as those prepared in Example 8.
[Evaluation methods]
The obtained product was applied to the back of a person and irradiated with UVB, and the sun protection effect SPF was calculated and evaluated according to the measurement method of the Japan Cosmetic Industry Association.
[0050]
[Table 7]
Improving the effectiveness of sun cream
* 2 : Sunscreen cream 2 (present invention)
* 3 : Sunscreen cream 3 (comparative example)
* 3 : Sunscreen cream 4 (present invention)
[0051]
As can be seen from the results of Table 7, the examples of the present invention (mixed extracts 3 and 4) were compared with each other when extracted with ethanol and extracted with 1,3-butylene glycol (Bidence Pilosa + ethanol). , Bidence Pilosa + 1,3-butylene glycol), a significant improvement in sun protection was observed.
[0052]
(Example 10)
After cutting and washing the above-ground part of Tachiawayukisendangusa, it was chopped to an appropriate length, boiled for about 1 hour, sent to hot air at 80 ° C. and dried by ventilation. Add 10kg of dried ginger to the 10kg, add 200L of water / methanol / 1,3-butylene glycol (1/1/2, v / v) mixture and leave it at room temperature for 1 week to extract and filter. The insoluble matter on the filter paper was sufficiently squeezed to obtain a filtrate. 0.5 kg of lactose was added to the obtained filtrate and spray-dried to obtain 2.9 kg of extract powder.
To this extract powder, 0.3 kg of Avicel (crystalline cellulose) as an excipient and 0.1 kg of sucrose fatty acid ester as a lubricant were added, and tableted to give a 250 mg tablet.
[0053]
Effect on cedar pollinosis
Five cedar pollinosis patients with symptoms such as sneezing, runny nose and itchy eyes were used as subjects. All five were taking measures such as wearing antiallergic agents and masks under the guidance of doctors, but their symptoms were still not relieved. When these five subjects stopped taking the doctor's medicine and took the tablet of the present invention three times a day on an empty stomach, the symptoms were clearly observed within 10 days as shown below. lost. As long as she continued taking the drug, she did not have any symptoms, but she developed after forgetting to take it for a few days.
[0054]
1) Y. S. Male 47 years old (company manager) 5-7 days had almost no symptoms and then did not recur.
2) S.M. T. T. Symptoms became very light in about a week for a 39-year-old male (company sales employee).
3) K. I. Male 44 years old (local public servant) almost disappeared after 4-5 days, and did not recur.
4) M.M. I. Male 75 years old (company officer) almost disappeared from hay fever several days later.
5) R.A. I. A woman 39 years of age (company clerical work) became symptomatic after about 10 days.
【The invention's effect】
As described above, the composition containing the extract obtained by the method of the present invention has an excellent effect as a therapeutic and preventive agent for hyperglycemia, dermatitis, hay fever, etc., and as a cosmetic product such as a skin beautifying agent or sunscreen. In addition, it is clearly superior to the extract of Bidence Pilosa alone.
Claims (8)
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| JP2003115703A JP4495406B2 (en) | 2003-04-21 | 2003-04-21 | Sendangusa plant extract-containing composition |
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| JP2006306769A (en) * | 2005-04-27 | 2006-11-09 | Toyo Hakko:Kk | Apoptosis inducing agent, food and drink and medicine containing the same, and method for producing the apoptosis inducing agent |
| JP2007197380A (en) * | 2006-01-27 | 2007-08-09 | Musashino Meneki Kenkyusho:Kk | Anti-histaminic agent comprising enzyme-treated product of plant belonging to genus bidens |
| EP2007408B1 (en) * | 2006-03-03 | 2019-05-01 | Csir | Preventative treatment and remission of allergic diseases |
| WO2008018138A1 (en) | 2006-08-10 | 2008-02-14 | Wood One Co., Ltd. | Hypoglycemic composition containing component originating in the bark of tree belonging to the genus acacia |
| WO2008018141A1 (en) | 2006-08-10 | 2008-02-14 | Wood One Co., Ltd. | Composition for preventing and/or treating itching containing component originating in the bark of tree belonging to the genus acacia |
| BRPI0621961A2 (en) | 2006-08-10 | 2011-12-27 | Wood One Co Ltd | antiobesity composition containing component originating from the bark of an Acacia genus |
| AU2006347125B2 (en) | 2006-08-10 | 2013-06-06 | Acacia-No-Ki Co., Ltd. | Antioxidant composition containing component originating in the bark of tree belonging to the genus Acacia |
| AU2006347123B2 (en) | 2006-08-10 | 2013-06-06 | Acacia-No-Ki Co., Ltd. | Composition for preventing and/or treating tumor containing component originating in the bark of tree belonging to the genus Acacia |
| KR101181797B1 (en) * | 2009-12-09 | 2012-09-17 | 노용수 | Method for Preparing Fermented Liquor of Epicarp of Ginkgo Biloba |
| GB2541319B (en) * | 2014-04-30 | 2019-04-24 | Kimberly Clark Co | The non-therapeutic use of a combination of a bidens extract and an undaria extract |
| US10548835B2 (en) | 2014-04-30 | 2020-02-04 | Kimberly-Clark Worldwide, Inc. | Methods of reducing the signs of skin aging |
| AU2014392689B2 (en) | 2014-04-30 | 2020-12-17 | Kimberly-Clark Worldwide, Inc. | Compositions and methods for reducing oxidative stress |
| WO2015167557A1 (en) | 2014-04-30 | 2015-11-05 | Kimberly-Clark Worldwide, Inc. | Topical compositions for stimulating adipogenesis and lipogenesis to reduce the signs of skin aging |
| WO2015167552A1 (en) * | 2014-04-30 | 2015-11-05 | Kimberly-Clark Worldwide, Inc. | Topical compositions including a bidens extract for reducing signs of skin aging |
| BR112016023571B1 (en) | 2014-04-30 | 2020-12-01 | Kimberly-Clark Worldwide, Inc. | methods to reduce the signs of skin aging in an individual, to increase the adipogenesis of an individual's face and body and to increase the lipogenesis of an individual's face and body |
| CN109984963B (en) * | 2019-05-13 | 2022-02-11 | 烟台新时代健康产业日化有限公司 | Preparation method of pine pollen-turmeric antioxidant skin care product |
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