KR100839030B1 - Composition for improving atopic dermatitis or acne - Google Patents

Abstract

A skin external composition comprising bamboo vinegar and Bambusae Caulis in Liquamen and/or bamboo sap is provided to show excellent atopic dermatitis or acne therapeutic effect. A skin external application composition for improving atopic dermatitis or acne comprises bamboo vinegar and at least one of bamboo sap and Bambusae Caulis in Liquamen. The composition is a cosmetic composition, a pharmaceutical composition or a soap composition.

Description

Composition for Improving Atopic Dermatitis and Composition for Acne Improvement {Composition for Improving Atopic Dermatitis or Acne}

The present invention relates to an atopic dermatitis improving composition and acne improving composition comprising a fire power and raw bamboo power in addition to the bamboo vinegar solution.

Atopy is derived from the Latin word atopia, which means 'weird'. Atopic dermatitis is a disease characterized by severe itching and chronic skin rashes, the most common form of infantile eczema.

The cause of atopic dermatitis has not yet been clearly identified.However, a person with atopic dermatitis usually has an allergic reaction to foreign substances such as house dust, mites, animal hair, food, pollen, or mold. In addition, atopic dermatitis is believed to be caused by disturbance of the immune system in that it is accompanied by allergic rhinitis, asthma, conjunctivitis and the like.

Steroid-based drugs have excellent anti-inflammatory and immunosuppressive effects. However, long-term use causes side effects such as hairs on the right area, atrophy of the skin, less skin pigment, and thinner skin.

On the other hand, acne is known to be caused by sebum hypersecretion, pore closure by hair follicle hyperkeratosis, and skin inflammation caused by free fatty acids produced by decomposition of sebum under the influence of acne bacteria (Propionibacterium acnes). .

Existing major acne treatments include macrolides such as erythromycin and clindamycin, tetracycline antibiotics, and vitamin A (isotretinoin), but these drugs are known to cause side effects such as hormonal changes.

Recently, in order to minimize the side effects of existing chemicals, efforts are being made to find natural extracts effective for atopic dermatitis or acne. For example, Korean Patent No. 0513659 (Ginseng, Palatinum, Gemini, which is effective in improving atopic dermatitis). And discloses a mixed extract of leaflet vegetation) or Korean Patent No. 0584039 (discloses a vine tea extract that is effective in improving atopic dermatitis), Korean Patent No. 0491746 (extracts of barberry extract that are effective in improving acne Is disclosed).

The present invention is also derived from the point of view of using a natural extract for the treatment of atopic dermatitis and acne, in particular, the present invention is very effective in treating atopic dermatitis or acne when the mixture of bamboo vinegar and fire and / or dying power It is completed by confirming.

Accordingly, an object of the present invention is to provide an atopic dermatitis improving composition.

Another object of the present invention to provide an acne improver composition.

Other objects, specific embodiments, and the like of the present invention will be provided below.

The present inventors, as confirmed in the following Examples and Experimental Examples, to prepare a cosmetic lotion composition comprising a mixture of bamboo vinegar liquor and kneading power and / or raw bamboo power, the effect of improving the atopic dermatitis and acne improvement effect of the cosmetic lotion composition As a result of clinical examination, it was confirmed that the effect of each of the bamboo vinegar, bamboo power or raw bamboo power is superior.

In particular, the present inventors were able to confirm that the case of the skin lotion composition prepared by including both bamboo vinegar and fire power and raw bamboo power is very effective in improving atopic dermatitis and improving acne.

These results indicate that the mixture of bamboo vinegar and firepower and / or raw bamboo power (a mixture of bamboo vinegar and firepower, a mixture of bamboo vinegar and live bamboo power or a mixture of bamboo vinegar and fire power and fresh bamboo power) is very effective in improving atopic dermatitis and acne. It can be said that it can.

Therefore, the present invention, in one aspect, can be understood as a composition for improving atopic dermatitis, and in another aspect can be understood as a composition for improving acne.

The composition for improving atopic dermatitis and the acne improving composition of the present invention is characterized by including a bamboo power and / or fresh bamboo power in addition to the bamboo vinegar solution.

The following terms herein have the meanings as defined below.

First, "jujube liquor" refers to the middle layer of bamboo vinegar obtained by trapping the smoke produced when carbonizing bamboo directly, cooling and condensing the crude bamboo vinegar (粗 竹 酢 液), and then discarding the upper and lower layers, which are oily layers. It means the purified bamboo vinegar liquid from which the tar component was further removed by the static method, distillation method (pressure distillation method or atmospheric distillation method), or the filtration method (using filter paper and / or activated carbon) from this middle layer bamboo vinegar solution. There is no limit to the type of bamboo that can be used to obtain this bamboo vinegar. Thus, they are classified as botanical taxonomic bamboo, whether bamboo belonging to Phyllostachys, bamboo belonging to Arundinaria, bamboo belonging to Sasa or bamboo belonging to Pseudosasa. Any plant (ie, rice plant bamboo) can be used in the bamboo vinegar solution. As used herein, the term "direct carbonization" means that carbonization is performed without the mediation of a heat transfer medium, such as a pot, a metal container, and the like, unlike the fire power described below.

The next "fire bamboo" refers to the fire power of the middle layer obtained by leaving the upper and lower layers of the meteor layer after leaving the raw crude liquid, which is the bamboo essence obtained when carbonizing bamboo indirectly, It means a refined firepower in which the tar component is further removed from the force by the above-described static method, distillation method or filtration method. The term "indirectly carbonize" herein means that the bamboo is carbonized by heat being transferred to the bamboo through a heat transfer medium such as a pot containing shredded bamboo, a metal container, or the like. Likewise, there is no limit to the type of bamboo that can be used to gain firepower.

The next "raw bamboo" (生 竹瀝) refers to the bamboo's essence obtained by scarring the bamboo. Normal bamboo shoots are obtained by harvesting the lobster liquor that cuts off the ends of bamboo when the growth of bamboo is vigorous in early spring. Likewise, there is no limit to the type of bamboo that can be used to gain raw bamboo.

The following "acne" is defined to include any disease classified as acne in the art, regardless of the direct or indirect cause of its occurrence. As can be seen in the following experimental example of the present invention, as a result of clinical trials conducted on 60 subjects with randomly elected acne disease (20 per group and 3 cosmetic compositions of the examples), It was found that the use of the lotion including the killing and / or killing was effective for about 60 to 80% of the subjects. Since these results are obtained from randomly selected subjects, it can be seen that the acne improvement composition of the present invention is effective in all types of acne regardless of the cause of acne. Therefore, the meaning of the acne is, for example, collective acne, acne caused by bromide, general acne, congoblate acne, acne by using cosmetics, acne by using detergent, acne dtergicans, adolescent acne , Acne fulminans, acne furunculoid, halogenated acne, callus acne, keloid acne, physical acne, mechanical acne, drug acne, necrotic acne, lip acne Acne, newborn acne (acne neonatorum), oily acne (acne oil), papule acne, pomade acne, premenstrual acne, acne rosacea, swelling acne, tropical acne, addictive acne (acne venenata), acne vulgaris and the like are all understood to be included.

The following "atopic dermatitis" is also defined to include all diseases classified as atopic dermatitis in the art, regardless of the direct or indirect cause of its occurrence. Atopic dermatitis is generally classified into infantile atopic dermatitis, pediatric atopic dermatitis, adult atopic dermatitis and maternal atopic dermatitis, according to the time of its onset or subject of the invention, where atopic dermatitis includes all these types of atopic dermatitis. It is defined as. Atopic dermatitis improvement composition of the present invention will be confirmed in the following Examples and Experimental Examples of the present invention will have the effect of improving all types of atopic dermatitis.

The following "improvement" means treatment, prevention and alleviation of symptoms.

On the other hand, in the composition for improving atopic dermatitis or acne improving composition (hereinafter collectively referred to as the "composition of the present invention") of the present invention, the active ingredients of bamboo vinegar and abrasion power and / or dying power of the symptoms of atopic dermatitis or acne Depending on the degree it may be included in any amount within the range that does not have toxicity to the human body, specifically, may be included in 0.001% to 99.99% by weight based on the total weight of the composition, preferably 0.001% by weight To 15% by weight.

The composition of the present invention is a compound or plant that is known to have an acne-improving effect or an atopic dermatitis-improving effect in order to enhance or enhance the acne-improving effect or atopic dermatitis effect, in addition to its active ingredients, bamboo vinegar and firepower and / or fresh-boiling force Extracts, such as vitamin A, phytandiolamine (WO 2003/037845), benzofuran derivatives (US Pat. No. 4,775,663), isoflavones (Korean Patent No. 439147), tetracycline compounds, benzoyl peroxides , Triclosan, salicylic acid, retinyl palmitate, octoxyglycerol, rosemary extract, sage extract, antihistamine (Hydroxyzine, Acrivastine, etc.) and the like, but are not limited thereto.

In a preferred aspect, the composition of the present invention preferably comprises both the bamboo vinegar and the bamboo power and raw bamboo power. This is because the improvement effect was the best when it included both the bamboo vinegar solution and the bamboo power and raw bamboo power as shown in the following Examples and Experimental Examples. At this time, their preferred compounding ratio is bamboo herb solution: bamboo power: fresh bamboo power = 2: 1: 1.

The composition of the present invention can be regarded as a cosmetic composition in specific embodiments.

When the composition of the present invention is conceived as a cosmetic composition, the cosmetic composition can be prepared in various forms, for example, emulsions, lotions, creams (oil-in-water, water-in-oil, multiphase), solutions, suspensions (anhydrous and Aqueous), anhydrous products (oil and glycol based), gels, masks, packs, powders and the like.

The cosmetic composition of the present invention may include an acceptable carrier in cosmetic preparations in addition to bamboo liquor and agglomerate and / or dyke.

Herein, "acceptable carriers in cosmetic preparations" are compounds or compositions already known and used that may be included in cosmetic preparations, or compounds or compositions which will be developed in the future, which have no toxicity, instability or irritation more than the body can adapt to in contact with the skin. Say that.

The carrier may be included in the cosmetic composition of the present invention in an amount from about 1% to about 99.99% by weight, preferably from about 90% to about 99.99% by weight of the composition.

However, since the ratio will vary depending on the formulation as described above in which the cosmetic composition of the present invention is prepared and its specific application site (face, neck, etc.) or its preferred application amount, the ratio is in any aspect to the present invention. It should not be understood as limiting the scope of.

Meanwhile, examples of the carrier include alcohols, oils, surfactants, fatty acids, silicone oils, wetting agents, moisturizers, viscosity modifiers, emulsions, stabilizers, sunscreen agents, colorants, fragrances, and the like.

The alcohols, oils, surfactants, fatty acids, silicone oils, wetting agents, moisturizers, viscosity modifiers, emulsions, stabilizers, sunscreens, colorants, compounds / compositions that can be used as fragrances and the like are already known in the art, Appropriate materials / compositions may be selected and used.

Meanwhile, the composition of the present invention may be regarded as a pharmaceutical composition in another specific embodiment.

When the composition of the present invention is identified as a pharmaceutical composition, the pharmacological effect can be identified as an atopic dermatitis improving effect, acne improving effect.

The pharmaceutical composition of the present invention may include a pharmaceutically acceptable carrier in addition to the bamboo vinegar and fire and / or raw bamboo power as an active ingredient, such a pharmaceutically acceptable carrier is commonly used in pharmaceutical formulations, Lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methyl cellulose, methyl hydride Hydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, and the like. The pharmaceutical compositions of the present invention may also further comprise lubricants, wetting agents, sweetening agents, flavoring agents, emulsifying agents, suspending agents, preservatives and the like as additives.

The carrier may be included in the pharmaceutical composition of the present invention in an amount of about 1% to about 99.99% by weight, preferably about 90% to about 99.99% by weight, based on the total weight thereof, and the additive is about 0.1% by weight. To about 20% by weight.

On the other hand, the pharmaceutical composition of the present invention may be administered orally or parenterally, and most preferably, directly to the skin in a topical mode of administration.

The pharmaceutical compositions of the present invention can be prepared in unit dose form or formulated into pharmaceutically acceptable carriers and / or excipients or incorporated into multi-dose containers. In this case, the formulation may be in the form of a solution, a suspension or an emulsion, or may include an exercire, an excipient, a powder, a granule, a tablet, a warning, a coughing agent, a lotion, an ointment, and the like.

The daily dosage of the pharmaceutical composition of the present invention is usually 0.001 ~ 150 mg / kg body weight range, it can be administered once or divided into several times. However, since the dosage of the pharmaceutical composition of the present invention is determined in view of various related factors such as the route of administration, the age, sex, weight of the patient, and the severity of the patient, the dosage may limit the scope of the present invention in any aspect. It should not be understood as.

The composition of the present invention may be regarded as a functional food composition in another specific embodiment.

The food composition of the present invention may be prepared from gums, vitamin complexes, dietary supplements, special nutritional supplements, functional drinks, and the like.

To the food composition of the present invention, in addition to the addition of bamboo vinegar liquor and fire power and / or raw bamboo power, glucose, monosaccharides such as fructose, disaccharides such as maltose, sucrose, or polysaccharides such as dextrin, cyclodextrin may be added, Sugar alcohols such as xylitol, sorbitol, erythritol and the like may also be added, sweeteners such as taurine, stevia extract and the like may also be added, and other food additives may be added.

The composition of the present invention may be regarded as a soap composition in another specific embodiment.

When the composition of the present invention is understood as a soap composition, the soap composition of the present invention may be prepared by including bamboo vinegar solution and fire power and / or raw bamboo power on the soap base, and may be used as an additive such as skin moisturizer, emulsifier, water softener, and the like. It can be prepared to include.

As the soap base material, vegetable oils such as palm oil, palm oil, soybean oil, perm oil, olive oil, palm kernels, or animal oils such as tallow, pork, sunny and fish oils can be used, and the skin moisturizing agent is glycerin, erythritol and polyethylene glycol. , Propylene glycol, butylene glycol, pentylene glycol, hexyl glycol, isopropyl myristate, silicone derivatives, aloe vera, sorbitol and the like can be used, the emulsifiers include natural oils, wax fatty alcohols, hydrocarbons, natural plant extracts, etc. May be used, and tetrasodium idieti or the like may be used as the water softener.

The soap composition of the present invention may further include an antimicrobial agent, a dispersant, a foam inhibitor, a solvent, a scale inhibitor, a corrosion inhibitor, a perfume, a pigment, a metal ion sequestrant, an antioxidant, a preservative, and the like as an additive.

In the soap composition of the present invention, the soap base or additives may be included in an amount generally used in the art, and the soap base is generally added in an amount of 99.999 wt% to 50 wt% based on the total weight of the soap composition. The additive may be added in an amount of 1% to 20% by weight.

<Reference Example> Preparation of bamboo smoke distillate, flower production, and tabasheer tabasheer

<Reference Example 1> Preparation of BV

Bamboo shoot liquor was prepared according to the conventional method of preparing bamboo shoot liquor. First of all, the smoke produced by carbonizing powdered bamboo from Damyang, Jeonnam was cooled and condensed to obtain crude bamboo vinegar (粗 竹 酢 液), which was placed in a plastic container and allowed to stand for about a year. The crude bamboo liquor in the container was separated into three layers over time. The oily layer, the upper layer (the black light oil component layer) and the lower layer (tar layer), was discarded and the middle layer of bamboo vinegar solution was taken. Since the bamboo tar liquor contained a trace amount of tar, the tar component was removed again by the static method (here, the standing time is about one year), and finally, the purified bamboo liquor liquid was obtained.

REFERENCE EXAMPLE 2 Preparation of Fire Ability

Prepared firewood according to the traditional method. In other words, the powder collected from Damyang, Jeonnam was cut into 20cm to 40cm in length and placed tightly in Onggi, and the inlet of Onggi was closed with a cloth. Another pot was buried in the ground so deep that the entrance of the pot would go into the ground. After turning the pottery with the shredded bamboo on, and aligning the entrance with the other pottery buried in the ground so that the entrances of the two pottery abut, the ocher was opened in water to completely seal the pottery on the ground. Finally, a large amount of chaff was piled up around the clay that covered the Onggi to set fire to the chaff and burn for about a day and a half. Next, the liquid flowing down from the heated bamboo flows into the pot, which is buried in the ground. Some of the tar ingredient is contained in the tar ingredient, and in order to remove the tar ingredient, the killing agent solution is left in a plastic container for one year to obtain a refined amalgam of the intermediate layer.

Reference Example 3 Preparation of Raw Dough

The end of the mountain porridge in the wild of Damyang, Jeonnam was cut off to extract the juice.

EXAMPLES Preparation of Cosmetic Water Composition

<Example 1-3> Preparation of lotion The composition Examples 1 to 3

As shown in the following Table 1, the skin lotion composition was prepared by adding the bamboo vinegar solution and the firepower and / or raw bamboo power obtained in the above reference example to the general lotion component.

division Example 1 (% by weight) Example 2 (% by weight)  Example 3 (% by weight) Bambooweed solution of Reference Example 1 3.0 3.0 3.0 Firepower of Reference Example 2 3.0 - 1.5 Raw strength of reference example 3 - 3.0 1.5 Beeswax 2.0 2.0 2.0 Pyromethicone 2.0 2.0 2.0 Liquid paraffin 5.0 2.0 2.0 Squalane 5.0 5.0 5.0 Stearic acid 2.0 2.0 2.0 Lipophilic monostearic acid glycerin 3.0 3.0 3.0 Macadamia oil 4.0 4.0 4.0 glycerin 4.0 4.0 4.0 Propylene glycol 3.0 3.0 3.0 Butylene glycol 3.0 3.0 3.0 Triethanolamine 1.0 1.0 1.0 Aluminum Magnesium Silicate 0.5 0.5 0.5 Pigment 12.0 12.0 12.0 antiseptic a very small amount a very small amount a very small amount Spices a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount

<Comparative Example> Preparation of a lotion composition

<Comparative Examples 1 to 3> Comparative Production Examples 1 to 3 of the lotion composition

As shown in Table 2 below, the bamboo vinegar solution, the bamboo fire power or the fresh bamboo power obtained in the above reference example was added to the general lotion component to prepare a lotion composition.

division Example 1 (% by weight) Example 2 (% by weight)  Example 3 (% by weight) Bambooweed solution of Reference Example 1 6.0 - - Firepower of Reference Example 2 - 6.0 - Raw strength of reference example 3 - - 6.0 Beeswax 2.0 2.0 2.0 Pyromethicone 2.0 2.0 2.0 Liquid paraffin 5.0 2.0 2.0 Squalane 5.0 5.0 5.0 Stearic acid 2.0 2.0 2.0 Lipophilic monostearic acid glycerin 3.0 3.0 3.0 Macadamia oil 4.0 4.0 4.0 glycerin 4.0 4.0 4.0 Propylene glycol 3.0 3.0 3.0 Butylene glycol 3.0 3.0 3.0 Triethanolamine 1.0 1.0 1.0 Aluminum Magnesium Silicate 0.5 0.5 0.5 Pigment 12.0 12.0 12.0 antiseptic a very small amount a very small amount a very small amount Spices a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount

<Experimental example> Sensory evaluation on atopic dermatitis and acne improvement effect

Experimental Example 1 Improvement of Atopic Dermatitis Patients

With the cooperation of a pediatric hospital in Gwangju, 20 children with atopic dermatitis using the lotion composition of the above example and the comparative example were subjected to sensory evaluation. The composition of each example or the composition of each comparative example was applied to the lesion site for a total of six weeks, two times each morning and evening.

Atopic dermatitis improvement evaluation was performed in two ways, one of which is the atopic dermatitis index (EASI score) showing the severity of atopic dermatitis. Atopy is spread, and the other method is a questionnaire form that is evaluated by the patient or the parents of the patients as a percentage of the total subjects who responded that the effect of the itch is improved.

The degree of change in the average value of the atopic dermatitis index is shown in Table 3 below. The questionnaire evaluation result for the itch is shown in Table 4 below as an average value.

division Atopic Dermatitis Index Change (△) Composition of Example 1 10.2 Composition of Example 2 10.9 Composition of Example 3 15.5 Composition of Comparative Example 1 6.9 Composition of Comparative Example 2 5.4 Composition of Comparative Example 3 5.7

<Table 3> shows that the aroma dermatitis index change value (△) is greater than the lotion composition prepared by mixing the bamboo vinegar with the bamboo power and / or raw bamboo power than the skin lotion composition prepared by including bamboo vinegar, bamboo power or raw bamboo power respectively. Shows.

division Sensory evaluation result Composition of Example 1 52% Composition of Example 2 55% Composition of Example 3 68% Composition of Comparative Example 1 42% Composition of Comparative Example 2 35% Composition of Comparative Example 3 34%

<Table 4> is also similar to the <Table 3> and the lotion composition prepared by mixing bamboo vinegar and / or raw bamboo power to further improve the itch than the lotion composition prepared by containing bamboo vinegar, bamboo power or raw bamboo power, respectively It is effective to make it.

In Tables 3 and 4, the lotion composition having the best effect on atopic dermatitis improvement is a lotion composition (composition of Example 3) including all of bamboo vinegar solution, aquatic power and raw bamboo power.

Example 2 Improvement on Acne Skin

With the cooperation of a dermatological hospital in Gwangju, the sensory evaluation was carried out using the skin lotion composition of the example and the skin lotion composition of the comparative example with 20 male and female adults suffering from acne as one group of subjects. The composition of each example or the composition of each comparative example was applied to the lesion site for a total of two weeks, two times each morning and evening.

Determination of the degree of acne improvement is a method of evaluating patients in the form of a questionnaire as a percentage of the total subjects who answered that the improvement effect on the items shown in Table 5 below.

Improved results for acne skin Test substance Itching improvement Skin redness improvement Skin irritation Composition of Example 1 59.0% 62.4% 58.9% Composition of Example 2 64.7% 67.5% 63.8% Composition of Example 3 78.9% 80.3% 82.4% Composition of Comparative Example 1 48.9% 47.3% 46.0% Composition of Comparative Example 2 41.3% 43.2% 40.5% Composition of Comparative Example 3 42.4% 41.3% 40.2%

<Table 5> also similar to the <Table 3> and <Table 4>, the lotion composition prepared by mixing the bamboo vinegar with the bamboo power and / or raw bamboo power, the cosmetic lotion composition prepared by containing bamboo vinegar, bamboo power or raw bamboo power, respectively More effective in improving itching.

The lotion composition that is most effective in improving acne is a lotion composition (composition of Example 3) including both the bamboo vinegar solution and fire power and raw bamboo power.

As described above, according to the present invention can provide a composition for improving atopic dermatitis and acne-improving composition comprising bamboo vinegar solution and fire power and / or raw bamboo power.

Claims (8)

In addition to the bamboo vinegar, a topical dermatitis composition for improving atopic dermatitis, characterized in that it further comprises one or more of the firepower and raw bamboo power. In addition to the bamboo vinegar solution, the external composition for improving acne, characterized in that it further comprises one or more of the fire power and dying power. The method according to claim 1 or 2, The composition is an external composition for skin, characterized in that it comprises both bamboo vinegar and fire power and raw bamboo power. The method of claim 3, The weight ratio of the bamboo vinegar and the bamboo power and raw bamboo power is bamboo shoot liquid: bamboo power: fresh bamboo power = 2: 1: 1 skin external composition. The method according to claim 1 or 2, The composition is a composition, characterized in that the cosmetic composition. The method according to claim 1 or 2, The composition for external application of skin, characterized in that the pharmaceutical composition. delete The method according to claim 1 or 2, Wherein said composition is a soap composition.