CN104490712B - A kind of Chinese medicine composition with senile-resistant efficacy and its application in cosmetics - Google Patents
A kind of Chinese medicine composition with senile-resistant efficacy and its application in cosmetics Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition with senile-resistant efficacy, it is made up of following components in percentage by weight：Female withers 30~40%, purple sesame 15~25%, lily 15~20%, moutan bark 10~15%, iris 5~10%, Liu Hua 3~5%.Application invention additionally discloses the preparation method of the Chinese medicine composition with senile-resistant efficacy and in cosmetics.It is an advantage of the invention that：Energy nutritious tonifying, promote skin cell metabolism, improve skin immunity, delaying skin aging, make an addition in cosmetics, it is notable to nourish anti-ageing effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition with senile-resistant efficacy and its
Application in cosmetics.
Background technology
Vigorous and graceful skin mark the healthy and beautiful of people, and smooth, careful and flexible skin is that people chase jointly
Target.The aging of skin is a kind of natural law, although we can not prevent the natural aging of skin, can pass through science
Effective measures, change the aging state of skin.
Research of the traditional Chinese medical science to the mechanism of aging is of long standing and well established.The traditional Chinese medical science thinks that aging belongs to Zi Ran Now as being with human five internal organs six
The hypodynamia of internal organs, from Inner to a series of changes of outer generation.These changes cause the function of human body increasingly to decline.Theory of traditional Chinese medical science
Recognize woman with yangming meridian decline for begin, with face it is aged for the external tendency for describing change, this mainly due to the kidney qi cold of insufficiency type,
Caused by weakness of the spleen and the stomach, qi stagnation blood stasis, so the core of successive dynasties traditional Chinese medical science anti-aging is based on invigorating the kidney and spleen.In addition to help prescription,
Other prescriptions of selected parts, it is such as promoting blood circulation and removing blood stasis, dehumidifying resolving sputum, promoting the circulation of qi is soothing the liver, come reach it is anti-ageing preserve youthful looks, support member consolidate, macrobiosis of making light of one's life by commiting suicide
Purpose.
Now, doctor trained in Western medicine it is anti-ageing uses external therapy to attach most importance to take stopgap measures, though it is effective in cure fast the advantages of, curative effect is very unstable.
Chinese medicine is anti-ageing to be particular about the thin reason of slow tune, and based on effecting a permanent cure, curative effect is also relatively stable, and this is one very traditional, but persistently effective
Method.
The content of the invention
The purpose of the present invention is to combine Chinese tradition theory of traditional Chinese medical science basis, there is provided a kind of natural safety has anti-aging work(
The Chinese medicine composition of effect.
The second object of the present invention is to provide the preparation method of the above-mentioned Chinese medicine composition with senile-resistant efficacy.
The third object of the present invention is to provide application of the Chinese medicine composition with senile-resistant efficacy in cosmetics.
To achieve the object of the present invention, present invention employs following technical scheme：Chinese traditional medicine composition with senile-resistant efficacy
Thing, it is made up of following components in percentage by weight：Female withers 30~40%, purple sesame 15~25%, lily 15~20%, moutan bark 10
~15%, iris 5~10%, Liu Hua 3~5%.
Preferably, the Chinese medicine composition (I) with senile-resistant efficacy is made up of following components in percentage by weight：Female
Wither 35%, purple sesame 23%, lily 18%, moutan bark 13%, iris 7%, Liu Hua 4%.
Preferably, the Chinese medicine composition (II) with senile-resistant efficacy is made up of following components in percentage by weight：
Female withers 38%, purple sesame 22%, lily 18%, moutan bark 13%, iris 6%, Liu Hua 3%.
Preferably, the Chinese medicine composition (III) with senile-resistant efficacy is made up of following components in percentage by weight：
Female withers 38%, purple sesame 20%, lily 18%, moutan bark 13%, iris 7%, Liu Hua 4%.
The preparation method of the above-mentioned Chinese medicine composition with senile-resistant efficacy, the step of it includes, are as follows：By said ratio
Weigh Chinese medicine material female wither, purple sesame, lily, moutan bark, iris, Liu Hua, above-mentioned Chinese medicine is crushed, after sieving be well mixed, press
Mass ratio is 1：15~1：20 are added to volume fraction in 60%~80% alcohol, 50~80 DEG C of 1~3h of heating extraction, to extract
1~3 time, filtering, merging filtrate, original volume 1/5~1/15, then upper model D101 macroporous resin columns purifying are concentrated under reduced pressure into,
Collected volume fraction is 30%~80% alcohol elution fraction, and the mass ratio for being concentrated under reduced pressure into extract solution and Chinese medicine material is 1：
0.5~1：10, add and dissolved with the butanediol of concentrate equal quality, filtering, Chinese medicine composition extract is made.
The Chinese medicine composition that the present invention has senile-resistant efficacy is used in facial mask class cosmetics, can make property it is stable,
The anti-aging cosmetics to work well.
The Chinese medicine composition with senile-resistant efficacy is used to prepare facial mask class cosmetics, and its dosage is 2~25%, excellent
It is 5~15% from amount.
The beneficial effects of the invention are as follows：The traditional Chinese medical science thinks that kidney is " the congenital foundation ", and main store essential substances gives birth to marrow, nephroyin and nephroyang of residing, kidney qi
Prosperity and decline be directly connected to people grow so that the overall process of aging；Spleen is " the foundation of acquired constitution ", source of generating QI and blood, main transporting
Rise clear, to be transferred for human body ascending or descending movement of vital Qi hinge.Invigorating the kidney and spleen is the key of traditional Chinese medical science anti-aging, while takes aggregate measures, saves
Select other prescriptions, improve anti-aging curative effect, reach anti-aging preserve youthful looks, support member consolidate, the purpose for macrobiosis of making light of one's life by commiting suicide.
In inventive formulation, female withers for monarch, and female withers sweet, flat, Return liver, spleen, large intestine channel, and it is sweet more that ancients think that female withers
Fat, is soft and moist product, skin-nourishing and to eliminate face black dry,《Sheng Nong's herbal classic》Described in：" long term usage, go to face black dry, good color
It is moist "；Purple sesame, lily, moutan bark collaboration are minister, and purple sesame is sweet, warm, help the five internal organs, strengthens the body resistance to consolidate the constitution, and has the work of anti-aging
With,《Sheng Nong's herbal classic》Described in:" main deafness, sharp joint, protecting god, strengthening the essence gas, hard muscles and bones, good color "；Lily is bitter, pungent, micro-
It is cold, the thoughts of returning home, liver and kidney channel, clearing away the heart fire and tranquillizing, Yin nourishing and lung moistening, nourishing essence-blood,《Bencao Jingshu》Medium cloud：" and day is cleer and peaceful, it is sweet to mend
In, the clear then gas of heat is given birth to, therefore tonifying middle-Jiao and Qi "；Moutan bark is bitter in taste, pungent, is slightly cold, the thoughts of returning home, liver and kidney channel, clearing heat and cooling blood, promoting blood circulationization
The stasis of blood,《Japan hanako materia medica》In be loaded with " remove pathogenic factor, please color, clearance natural fibre line of meat blood vessels "；Iris is assistant, promoting blood circulation, expelling wind and removing dampness, is detoxified
Disperse accumulations,《Sheng Nong's herbal classic》In say its " main broken a lump in the abdomen causing distension and pain "；Liu Huawei makes, and bitter, which can drop, to be let out, heat drop fire cold in nature of dispelling, heat conduction
It is descending,《Sheng Nong's herbal classic》It is black that middle theory " can eliminate face heat ".
Modern medicine proves that female withers containing 25.6~30.6% starch and mucilaginous substance, can effectively improve dry and cracked coarse
Skin, desalinate the color spot as caused by Exposure to Sunlight, bright color, go deep into skin and nourish reparation, make skin consolidation flexible；Ganoderma lucidum
Main component is organic germanium and macromolecule polysaccharide body, can strengthen epidermal cell vigor, enhance metabolism, and improves body resistance
Power, regulation of physiological functions, prevent dry skin life wrinkle；Lily has the work(of good nutritious tonifying, rich in lymphatic temperament and vitamin,
It is beneficial to skin cell metabolism, there is anti-aging and other effects；Moutan bark is just used as whitening good medicine, external application energy from ancient times
Anti-inflammatory, stimulate circulation, brilliant white skin and light spot；Iris can repair skin cell because of aging and impaired, and it is thin to promote skin living
Born of the same parents itself metabolism, extend survival and the regeneration period of skin cell, allow skin presentation to compact, be plentiful, bullet profit；Willow Hua Lin
Oedema is cured mainly on bed, jaundice, face are black and hot, have damp color, remove black dry, the treatment face sore in face, soft skin and other effects.
Above all medicines share, can Synergistic, foster member consolidates, qi-supplementing, blood-engendering, the foster skin of honor, plays conditioning viscera, balance altogether
The work(of negative and positive, control anti-ageing preserve youthful looks originally.The Chinese medicine composition extract energy nutritious tonifying of the present invention, promote skin cell new old generation
Thank, improve skin immunity, delaying skin aging, make an addition in cosmetics, it is notable to nourish anti-ageing effect.
Embodiment
Below by way of specific embodiment come the present invention is further illustrated, but these embodiments simply to illustrate that,
It is not limitation of the present invention.
Embodiment 1 has the Chinese medicine composition (I) and preparation method of senile-resistant efficacy
Chinese medicine material female is weighed by proportioning to wither 35g, purple sesame 23g, lily 18g, moutan bark 13g, iris 7g, Liu Hua 4g, will
Above-mentioned Chinese medicine composition crushes, and is well mixed after crossing 80 mesh sieves, and the concentration for being added to 2L is 80 DEG C of heating extractions in 80% alcohol
3 times, extraction 2 hours, after being filtered to remove medicine residue, merging filtrates, 600mL are concentrated under reduced pressure at 60 DEG C, is carried above every time
Liquid upper model D101 macroporous resin columns purifying again is taken, 70% alcohol elution fraction is collected, is concentrated under reduced pressure under the conditions of 50 DEG C
50g concentrates, 50g butanediols are added, filtered, 100g traditional Chinese medicine composition extract liquids are made.
Embodiment 2 has the Chinese medicine composition (II) and preparation method of senile-resistant efficacy
Chinese medicine material female is weighed by proportioning to wither 38g, purple sesame 22g, lily 18g, moutan bark 13g, iris 6g, Liu Hua 3g, will
Above-mentioned Chinese medicine composition crushes, and is well mixed after crossing 80 mesh sieves, and the concentration for being added to 2L is 80 DEG C of heating extractions in 80% alcohol
3 times, extraction 2 hours, after being filtered to remove medicine residue, merging filtrates, 600mL are concentrated under reduced pressure at 60 DEG C, is carried above every time
Liquid upper model D101 macroporous resin columns purifying again is taken, 70% alcohol elution fraction is collected, is concentrated under reduced pressure under the conditions of 50 DEG C
50g concentrates, 50g butanediols are added, filtered, 100g traditional Chinese medicine composition extract liquids are made.
The preparation of comparative example 1-6 single medicinal material extracts
Chinese medicine material female is weighed respectively to wither 100g, purple sesame 100g, lily 100g, moutan bark 100g, iris 100g, Liu Hua
100g, above-mentioned Traditional Chinese drug mixture is crushed, be well mixed after crossing 80 mesh sieves, the concentration for being added to 2L is 80 DEG C in 80% alcohol
Heating extraction 3 times, extraction 2 hours, after being filtered to remove medicine residue, merging filtrate, are concentrated under reduced pressure at 60 DEG C every time
600mL, above extract solution upper model D101 macroporous resin columns purifying again, collects 70% alcohol elution fraction, in 50 DEG C of conditions
Under be concentrated under reduced pressure to obtain 50g concentrates, add 50g butanediols, filter, 100g female is made and withers extract solution, purple sesame extract solution, lily
Extract solution, moutan bark extract solution, iris extract solution, Liu Hua extract solutions.
3 anti-ageing mask of embodiment and its preparation
Table 1 provides the anti-ageing mask formula of the Chinese medicine composition extract containing the present invention.
Table 1
Its preparation method：
1st, addition phase raw material methyl hydroxybenzoate and Nipasol are dissolved by heating to clear in 1.3- butanediols in advance,
It is standby.
2nd, Aqueous Phase Raw Material is put into deionized water, is heated to 75~85 DEG C, stirring is to being uniformly dissolved.
3rd, aqueous phase is cooled to 60 DEG C, the methyl hydroxybenzoate that is slowly added to have dissolved in advance while stirring, Nipasol and
1.3- butanediols, stirring is to being uniformly dissolved.
4th, 40 DEG C are cooled to, adds the Chinese medicine composition (I) with senile-resistant efficacy, then aminomethyl propanol regulation pH is added dropwise
It is worth to 5~6.
5th, stir, be cooled to 35 DEG C, 400 mesh discharge after repetition measurement pH, you can.
It is prepared by the anti-aging sleep mask of embodiment 4 and its preparation
Table 2 provides the anti-aging sleep mask formula of the Chinese medicine composition extract containing the present invention.
Table 2
Its preparation method：
1st, the advance stirring and dissolving of oil phase raw material will be added phase raw material methyl hydroxybenzoate and Nipasol is advance to being uniformly dispersed
Dissolved by heating in 1.3- butanediols to clear, it is standby.
2nd, Aqueous Phase Raw Material is put into deionized water, is heated to 75~85 DEG C, stirring is to being uniformly dissolved.
3rd, by oil phase, (1000~2000rpm) is slowly at the uniform velocity added in aqueous phase under agitation, after addition,
Emulsified again under 4000~6000rpm of matter speed 5~10 minutes.
4th, 40 DEG C are cooled to, adds Chinese medicine composition (I) and essence with senile-resistant efficacy, then aminomethyl propanol is added dropwise
PH value is adjusted to 5.5~6.5.
5th, stir, be cooled to 35 DEG C, vacuum defoamation after repetition measurement pH, filtering and discharging, you can.
It is prepared by the normal sleep facial mask of comparative example 7
Table 3 provides the normal sleep face pack prescription for not containing the Chinese medicine composition extract of the present invention.
Table 3
Its preparation method：
1st, the advance stirring and dissolving of oil phase raw material will be added phase raw material methyl hydroxybenzoate and Nipasol is advance to being uniformly dispersed
Dissolved by heating in 1.3- butanediols to clear, it is standby.
2nd, Aqueous Phase Raw Material is put into deionized water, is heated to 75~85 DEG C, stirring is to being uniformly dissolved.
3rd, by oil phase, (1000~2000rpm) is slowly at the uniform velocity added in aqueous phase under agitation, after addition,
Emulsified again under 4000~6000rpm of matter speed 5~10 minutes.
4th, 40 DEG C are cooled to, adds essence, aminomethyl propanol is added and adjusts pH value to 5.5~6.5.
5th, stir, be cooled to 35 DEG C, vacuum defoamation after repetition measurement pH, filtering and discharging, you can.
The Kangshuaining mixture clay mask of embodiment 5 and its preparation
Table 4 provides the Kangshuaining mixture clay mask formula of the Chinese medicine composition extract containing the present invention.
Table 4
Its preparation method：
1st, oil phase raw material is heated to 75~85 DEG C in oil phase pot, stirring is to being completely dissolved.
2nd, Aqueous Phase Raw Material is put into deionized water, is heated to 75~85 DEG C, stirred to kaolin, toner and other water
Phase stock dispersion is uniform.
3rd, homogeneous (3000~6000rpm) is opened, oil phase is slowly at the uniform velocity pumped into aqueous phase and emulsified, emulsified 20 minutes,
Open cycle water cools, and is kept stirring for.
4th, 40 DEG C are cooled to, Chinese medicine composition (II) and essence with senile-resistant efficacy is added, stirs.Vacuumize
Deaeration, you can.
The experimental method of embodiment 6 and anti-senescence function evaluation
1st, the preparation of sample
The Chinese medical extract of embodiment 1 and comparative example 1-6 is made into the sample solution that concentration is 1% respectively, carried out following
Experiment.
2nd, ultra-oxygen anion free radical Scavenging activity is evaluated
0.05mol/L pH=8.2 Tris-HCl buffer solution 4.5mL are taken, 20min is preheated in 25 DEG C of water-baths.Again plus
Enter 1mL samples and 0.4mL 25mmol/L pyrogallol solution, after mixing, 5min is reacted in 25 DEG C of water-baths, adds 8mol/
L HCl 1.0mL terminating reactions.Reference is made with Tris-HCl buffer solutions, absorbance is surveyed at 299nm.Blank control 1mL
The solvent of sample substitutes sample.Clearance rate (D) is calculated according to formula (1).
Ultra-oxygen anion free radical clearance rate (%)=[1- (A2/A1)] × 100% (1)
A1 is the absorbance of blank control in formula；A2 is the absorbance of sample.
3rd, the Scavenging activity of hydroxy radical is evaluated
2mmol/L FeSO are sequentially added in 25mL colorimetric cylinders43mL, 1mmol/L H2O23mL, shake up, be subsequently added into
6mmol/L salicylic acid 3mL, shake up, and are taken out after 37 DEG C of heating water bath 15min, survey its absorbance；It is separately added into certain density
Prepare liquid, shake up, continue heating water bath 15min, take out and survey its absorbance.Following formula is prepare liquid to the clear of hydroxy radical (OH)
Except rate：
Scavenging action to hydroxyl free radical (%)=[A1-A2- (A1-A3)]/A1 × 100% (2)
A1 is the absorbance of reaction system before non-dosing product in formula；A2 is the absorbance that sample removes system after OH
Value；A3 is the absorbance that system after OH is removed in blank control.
The anti-senescence function evaluation result of table 5
Experiment shows that Chinese medicine composition of the invention is up to 79.64% to superoxide anion clearance rate, clear to hydroxy radical
Except rate is up to 80.50%, illustrate that the synergy between composition is notable, to superoxide anion and Scavenging action to hydroxyl free radical higher than single
Taste Chinese medicine, there are good anti-aging effects.
The normal individual trial evaluation experimental of embodiment 7
1st, experimental method
Sleep mask prepared by embodiment 4, comparative example 7 carries out normal individual trial evaluation respectively.Healthy volunteer 60 is chosen,
Age, men and women half and half at 25~50 years old.2 groups are randomly divided into, every group of 15 males, 15 women.Each group carries out anti-aging respectively
The check experiment of sleep mask and normal sleep facial mask, left side use blank sample, and right side uses example sample on probation, before daily night sleeps
Using once, persistently try out 30 days, use the colour of skin that left face and right face are observed after one month.
Moisturizing degree, glossiness, degree of compacting and anti-wrinkle effect are carried out during use to sample to evaluate, wherein highest is divided into 5,
It is minimum to be divided into 1.
2nd, experimental result
Evaluation table on probation is filled according to sensory evaluation.Half face experiment evaluation table on probation is collected, statistical result is shown in Table 6：
The normal individual trial evaluation result average value of table 6
| Evaluation result | The sleep mask of comparative example 7 | The sleep mask of embodiment 4 |
| Moisturizing degree | 4 points | 4 points |
| Glossiness | 3 points | 5 points |
| Degree of compacting | 1 point | 4 points |
| Anti-wrinkle effect | 2 points | 4 points |
From the result of table 6, the result of the face test evaluation of human body half clearly can contrast this example sample and blank sample
The effect of product difference.Embodiment 4, comparative example 7 comparison in, positive effect in terms of the improvement of degree of compacting and anti-wrinkle effect, show
Face pack containing Chinese medicine composition extract of the present invention, there is the effect of good anti-aging is nourished, can allow fragile coarse
Loose skin speedy recovery to health state, smooth exquisiteness, compacts full.
Preferred embodiment of the invention described in detail above, be inventor take a large amount of manpower financial capacities and when
Between, test of many times come out it will be appreciated that, as a result, the ordinary skill of this area without creative work can according to this
Many modifications and variations are made in the design of invention.Therefore, all technician in the art according to present inventive concept in existing skill
, should be by this power by logic analysis, reasoning or according to the limited available technical scheme of experiment on the basis of art
Among protection domain determined by sharp claim.
Claims (8)
1. the Chinese medicine composition with senile-resistant efficacy, it is characterised in that be made up of following components in percentage by weight：Female withers 30
~40%, purple sesame 15~25%, lily 15~20%, moutan bark 10~15%, iris 5~10%, Liu Hua 3~5%；
The step of preparation method includes is as follows：By said ratio weigh Chinese medicine material female wither, purple sesame, lily, moutan bark, iris,
Liu Hua, above-mentioned Chinese medicine is crushed, be well mixed after sieving, be in mass ratio 1：15~1：20 be added to volume fraction for 60%~
In 80% alcohol, 50~80 DEG C of 1~3h of heating extraction, extract 1~3 time, filtering, merging filtrate, be concentrated under reduced pressure into original volume
1/5~1/15, then upper macroporous resin column purifying, collected volume fraction is 30%~80% alcohol elution fraction, is concentrated under reduced pressure into
The mass ratio of extract solution and Chinese medicine material is 1：0.5~1：10, add and dissolved with the butanediol of concentrate equal quality, mistake
Filter, Chinese medicine composition extract is made.
2. the Chinese medicine composition according to claim 1 with senile-resistant efficacy, it is characterised in that by following weight percent
The component of ratio is made：Female withers 35%, purple sesame 23%, lily 18%, moutan bark 13%, iris 7%, Liu Hua 4%.
3. the Chinese medicine composition according to claim 1 with senile-resistant efficacy, it is characterised in that by following weight percent
The component of ratio is made：Female withers 38%, purple sesame 22%, lily 18%, moutan bark 13%, iris 6%, Liu Hua 3%.
4. the Chinese medicine composition according to claim 1 with senile-resistant efficacy, it is characterised in that by following weight percent
The component of ratio is made：Female withers 38%, purple sesame 20%, lily 18%, moutan bark 13%, iris 7%, Liu Hua 4%.
5. according to the preparation method of any described Chinese medicine compositions with senile-resistant efficacy of claim 1-4, its feature exists
In, including the step of it is as follows：By said ratio weigh Chinese medicine material female wither, purple sesame, lily, moutan bark, iris, Liu Hua, will be upper
Chinese medicine crushing is stated, is well mixed after sieving, is in mass ratio 1：15~1：20 to be added to volume fraction be 60%~80% alcohol
In, 50~80 DEG C of 1~3h of heating extraction, extract 1~3 time, filtering, merging filtrate, be concentrated under reduced pressure into the 1/5~1/ of original volume
15, then the purifying of upper macroporous resin column, collected volume fraction be 30%~80% alcohol elution fraction, be concentrated under reduced pressure into extract solution and
The mass ratio of Chinese medicine material is 1：0.5~1：10, add and dissolved with the butanediol of concentrate equal quality, filtering, in being made
Drug composition extract.
6. according to any described Chinese medicine compositions with senile-resistant efficacy of claim 1-4 answering in cosmetics are prepared
With.
7. application of the Chinese medicine composition according to claim 6 with senile-resistant efficacy in cosmetics are prepared, it is special
Sign is：Facial mask class cosmetics are prepared, its dosage is 2~25%.
8. application of the Chinese medicine composition according to claim 7 with senile-resistant efficacy in cosmetics are prepared, it is special
Sign is：Facial mask class cosmetics are prepared, its dosage is 2~25%.
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| KR101829891B1 (en) * | 2017-08-04 | 2018-02-20 | 주식회사 아미코스메틱 | A cosmetic composition comprising osmanthus asiaticus extract and clematis apiifolia extract |
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