CN114272179A - Composition for skin repair and preparation method and application thereof - Google Patents
Composition for skin repair and preparation method and application thereof Download PDFInfo
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- CN114272179A CN114272179A CN202111652516.0A CN202111652516A CN114272179A CN 114272179 A CN114272179 A CN 114272179A CN 202111652516 A CN202111652516 A CN 202111652516A CN 114272179 A CN114272179 A CN 114272179A
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- centella asiatica
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- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 230000008439 repair process Effects 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 43
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 32
- 102000008186 Collagen Human genes 0.000 claims abstract description 21
- 108010035532 Collagen Proteins 0.000 claims abstract description 21
- 229920001436 collagen Polymers 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
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- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 claims abstract description 16
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 16
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- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- 229940039697 alkanna tinctoria root extract Drugs 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000000284 extract Substances 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 16
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- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 claims description 7
- 239000004229 Alkannin Substances 0.000 claims description 7
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 claims description 7
- 235000019232 alkannin Nutrition 0.000 claims description 7
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- 238000010438 heat treatment Methods 0.000 claims description 5
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N Glycyrrhetinic acid Natural products C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 3
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 3
- 229960003720 enoxolone Drugs 0.000 claims description 3
- 125000002168 glycyrrhetinic acid group Chemical group 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 229960005188 collagen Drugs 0.000 claims description 2
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- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 description 1
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- 230000002378 acidificating effect Effects 0.000 description 1
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 description 1
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a composition for skin repair, a preparation method and an application thereof, wherein the composition comprises the following raw materials in percentage by weight: 0.1-0.5% of carbomer, 0.1-0.5% of xanthan gum, 0.1-0.5% of sodium hyaluronate, 1-20% of glycerol, 0.1-2% of PEG-60 hydrogenated castor oil, 0.1-2% of recombinant collagen, 0.1-1% of licorice root extract, 0.1-1% of centella asiatica extract, 0.1-2% of 1, 2-hexanediol, 0.1-0.5% of p-hydroxyacetophenone, 0.1-0.5% of phenoxyethanol, 0.001-0.1% of alkanna tinctoria root extract, and the balance of deionized water, wherein the total amount is 100%. The facial mask provided by the invention has a powerful repairing effect under the compounding coordination of various skin repairing raw materials by reasonably utilizing the moisturizing repairing effect of the recombinant collagen, the anti-inflammatory and anti-allergic effect of the licorice root extract, the tightening repairing effect of the centella asiatica extract and the anti-inflammatory repairing effect of the alkanna tinctoria root extract.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a composition for skin repair and a preparation method and application thereof.
Background
With the increasing quality of life and the increasing interest in skin care needs of consumers, especially women, periodic and reasonable repeated purchases of cosmetics have become essential for daily life. Skin is the outermost tissue that provides barrier protection to the human body. Human skin, especially facial skin, is often damaged by skin related to various environmental stress factors such as ultraviolet rays, wind, haze and the like, and is damaged by long-term use of cosmetics such as color cosmetics. These injuries cause skin damage and inflammation, and seriously cause skin relaxation, roughness and wrinkle formation, and further cause skin immune function to be reduced. Therefore, the demand for cosmetics for accelerating skin repair is increasing. The mask is an important facial skin care product and is the largest cosmetic consumer variety, and a multi-effect repair mask is needed in the urgent market.
Disclosure of Invention
The purpose of the invention is as follows: the invention provides a composition for skin repair and a preparation method and application thereof, and experiments prove that a mask prepared from the composition has an obvious skin repair effect, is safe and has no side effect.
In order to achieve the purpose, the invention adopts the technical scheme that:
a composition for skin repair comprises the following raw materials in percentage by weight:
0.1-0.5% of carbomer, 0.1-0.5% of xanthan gum, 0.1-0.5% of sodium hyaluronate, 1-20% of glycerol, 0.1-2% of PEG-60 hydrogenated castor oil, 0.1-2% of recombinant collagen, 0.1-1% of licorice root extract, 0.1-1% of centella asiatica extract, 0.1-2% of 1, 2-hexanediol, 0.1-0.5% of p-hydroxyacetophenone, 0.1-0.5% of phenoxyethanol, 0.001-0.1% of alkanna tinctoria root extract, and the balance of deionized water, wherein the total amount is 100%.
Preferably, the composition comprises the following raw materials in percentage by weight:
0.1-0.3% of xanthan gum, 0.1-0.3% of sodium hyaluronate, 5-15% of glycerol, 0.3-1% of PEG-60 hydrogenated castor oil, 0.2-1% of recombinant collagen, 0.1-0.5% of licorice root extract, 0.1-0.5% of centella asiatica extract, 0.2-0.5% of 1, 2-hexanediol, 0.1-0.3% of p-hydroxyacetophenone, 0.1-0.3% of phenoxyethanol, 0.001-0.01% of alkanna tinctoria root extract and the balance of deionized water, wherein the total amount is 100%.
Preferably, the composition comprises the following raw materials in percentage by weight:
carbomer 0.1%, xanthan gum 0.2%, sodium hyaluronate 0.15%, glycerin 8%, PEG-60 hydrogenated castor oil 0.6%, recombinant collagen 0.5%, licorice root extract 0.2%, centella asiatica extract 0.2%, 1, 2-hexanediol 0.3%, p-hydroxyacetophenone 0.2%, phenoxyethanol 0.1%, alkanna tinctoria root extract 0.001%, and the balance of deionized water, the total amount being 100%.
Preferably, the purity of the recombinant collagen is not less than 95%.
Preferably, the licorice root extract is glycyrrhetinic acid monoglucuronide.
Preferably, the preparation process of the centella asiatica extract comprises the following steps:
weighing a certain mass of centella asiatica, leaching with 2-3 times of 90-95% ethanol for three times, each time for 10-20min, combining leaching solutions, concentrating at 45-55 ℃, and drying to obtain powder.
More preferably, the preparation process of the centella asiatica extract comprises the following steps:
weighing centella asiatica with a certain mass, leaching with 95% ethanol for three times, 15min each time, wherein the using amount of the 95% ethanol is 3 times of the weight ratio (3 times of the weight ratio is 3 of the weight ratio of the ethanol to the centella asiatica, and the following weight ratio has the same meaning and is not repeated), 3 times of the weight ratio and 2 times of the weight ratio, combining the leaching solutions, concentrating at 50 ℃, and drying to be powdery.
Preferably, the source of the alkannin root extract is the high-purity alkannin prepared by the method of example 3 in the Chinese patent 201510881298.6.
The preparation method of the composition for skin repair comprises the following steps:
adding carbomer, xanthan gum, sodium hyaluronate and glycerol into water, stirring for dissolving, heating, stirring for dissolving completely, cooling, adding PEG-60 hydrogenated castor oil, recombinant collagen, Glycyrrhrizae radix extract, herba Centellae extract, 1, 2-hexanediol, p-hydroxyacetophenone, phenoxyethanol and radix Arnebiae extract, supplementing evaporated deionized water, and stirring completely.
Preferably, in the method, carbomer, xanthan gum, sodium hyaluronate and glycerol are added into water and fully stirred for dissolving, the temperature is increased to 80-90 ℃ and stirred for complete dissolving, the temperature is reduced to 40-50 ℃, and then PEG-60 hydrogenated castor oil, recombinant collagen, licorice root extract, centella asiatica extract, 1, 2-hexanediol, p-hydroxyacetophenone, phenoxyethanol and alkanna tinctoria root extract are added.
The invention finally provides the use of said composition for preparing a cosmetic product for skin repair.
Has the advantages that: compared with the prior art, the invention reasonably utilizes the moisturizing and nourishing effects of the recombinant collagen, the anti-inflammatory and anti-allergic effects of the licorice root extract, the tightening effects of the centella asiatica extract and the anti-inflammatory and anti-allergic effects of the alkanna tinctoria root extract in the formula design, and the extracts have the synergistic effect when acting on the skin, so that the product has the effect of repairing the skin. The alkannin which aims at the local inflammation of skin injury can achieve the anti-inflammatory effect on the inhibition of tumor necrosis factor alpha (NF-alpha), and then the glycyrrhizic acid salt in the licorice root extract is cooperated to play the anti-inflammatory effect on the inhibition of the release of free histamine. In addition, the herba Centellae extract is rich in asiaticoside, and can exert repairing effect by protecting fibronectin and promoting fibroblast proliferation. Therefore, the various functional ingredients of the present invention are not simply combined but have a synergistic effect.
Detailed Description
In order to more concisely and clearly demonstrate technical solutions, objects and advantages of the present invention, the present invention will be further described in detail with reference to specific embodiments.
In the following examples:
the purity of the recombinant collagen is not lower than 95%.
The Glycyrrhrizae radix extract is glycyrrhetinic acid monoglucuronide.
The preparation process of the centella extract comprises the following steps: weighing herba Centellae with a certain mass, leaching with 95% ethanol for three times (15 min each time), wherein the ethanol content of 95% is 3 times, 3 times and 2 times respectively, mixing the leaching solutions, concentrating at 50 deg.C, and drying to obtain powder.
The source of the alkannin root extract is high-purity alkannin prepared by adopting example 3 in Chinese patent 201510881298.6.
Example 1
The multi-effect repairing facial mask comprises the following components in parts by weight: carbomer 0.3%, xanthan gum 0.3%, sodium hyaluronate 0.3%, glycerin 15%, PEG-60 hydrogenated castor oil 2%, recombinant collagen 2%, licorice root extract 1%, centella asiatica extract 1%, 1, 2-hexanediol 2%, p-hydroxyacetophenone 0.5%, phenoxyethanol 0.5%, alkanna tinctoria root extract 0.01%, and deionized water to 100%.
The multi-effect repairing facial mask is prepared by the following method:
adding carbomer, xanthan gum, sodium hyaluronate and glycerol into water, stirring for dissolving, heating to 85 deg.C, stirring for dissolving completely, cooling to 45 deg.C, adding PEG-60 hydrogenated castor oil, recombinant collagen, Glycyrrhrizae radix extract, herba Centellae extract, 1, 2-hexanediol, p-hydroxyacetophenone, phenoxyethanol and radix Arnebiae extract, supplementing evaporated deionized water, stirring thoroughly, detecting sensory physicochemical index, and packaging after qualified.
Example 2
The multi-effect repairing facial mask comprises the following components in parts by weight: carbomer 0.1%, xanthan gum 0.1%, sodium hyaluronate 0.1%, glycerin 5%, PEG-60 hydrogenated castor oil 0.1%, recombinant collagen 0.1%, licorice root extract 0.1%, centella asiatica extract 0.1%, 1, 2-hexanediol 0.1%, p-hydroxyacetophenone 0.1%, phenoxyethanol 0.1%, alkanna tinctoria root extract 0.001%, and deionized water to 100%.
The multi-effect repairing facial mask is prepared by the following method:
adding carbomer, xanthan gum, sodium hyaluronate and glycerol into water, stirring for dissolving, heating to 85 deg.C, stirring for dissolving completely, cooling to 45 deg.C, adding PEG-60 hydrogenated castor oil, recombinant collagen, Glycyrrhrizae radix extract, herba Centellae extract, 1, 2-hexanediol, p-hydroxyacetophenone, phenoxyethanol and radix Arnebiae extract, supplementing evaporated deionized water, stirring thoroughly, detecting sensory physicochemical index, and packaging after qualified.
Example 3
The multi-effect repairing facial mask comprises the following components in parts by weight: carbomer 0.1%, xanthan gum 0.2%, sodium hyaluronate 0.15%, glycerin 8%, PEG-60 hydrogenated castor oil 0.6%, recombinant collagen 0.5%, licorice root extract 0.2%, centella asiatica extract 0.2%, 1, 2-hexanediol 0.3%, p-hydroxyacetophenone 0.2%, phenoxyethanol 0.1%, alkanna tinctoria root extract 0.001%, and deionized water to 100%.
The multi-effect repairing facial mask is prepared by the following method:
adding carbomer, xanthan gum, sodium hyaluronate and glycerol into water, stirring for dissolving, heating to 85 deg.C, stirring for dissolving completely, cooling to 45 deg.C, adding PEG-60 hydrogenated castor oil, recombinant collagen, Glycyrrhrizae radix extract, herba Centellae extract, 1, 2-hexanediol, p-hydroxyacetophenone, phenoxyethanol and radix Arnebiae extract, supplementing evaporated deionized water, stirring thoroughly, detecting sensory physicochemical index, and packaging after qualified.
Example 4
Evaluation of sensory and physical Properties
The mask liquids prepared in example 3 were allowed to stand at 40 ℃ and-10 ℃ for 48 hours, respectively, and subjected to sensory and physical and chemical property tests, the results of which are shown in Table 1. As can be seen from Table 1, the facial mask liquid is pink in appearance, clear and transparent, weakly acidic, good in stability, mild and non-irritant to the face after application. The skin is fresh and comfortable after the use; after the skin-care product is used for a period of time by people with skin damage, red swelling and the like, the skin-care product is obviously improved.
TABLE 1 sensory and physicochemical Properties index test results
Example 5
Survey on mask trial
The mask prepared in example 3 was used for evaluation on a trial basis. 20 parts of trial evaluation sheets are provided, the evaluation indexes comprise comfort level, moistening degree, refreshing feeling and repairing effect, arithmetic mean statistics is adopted, and the final evaluation result is shown in table 2.
TABLE 2 evaluation statistics on trial
| Test items | Comfort level | Moistening degree | Refreshing feeling | Repairing effects |
| Score value | 4.7 | 4.4 | 4.6 | 4.5 |
Note: the table adopts a score of 5, from 5 to 1, and the scores are good, normal, poor and poor in sequence
As can be seen from Table 2, the scores are all above 4 points, which indicates that the mask prepared according to the invention is a multi-effect repairing mask.
It should be noted that the above mentioned embodiments are only preferred embodiments of the present invention, and are only used for illustrating the technical solutions of the present invention, but not limiting the same, and that several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.
Claims (9)
1. The composition for skin repair is characterized by comprising the following raw materials in percentage by weight:
0.1-0.5% of carbomer, 0.1-0.5% of xanthan gum, 0.1-0.5% of sodium hyaluronate, 1-20% of glycerol, 0.1-2% of PEG-60 hydrogenated castor oil, 0.1-2% of recombinant collagen, 0.1-1% of licorice root extract, 0.1-1% of centella asiatica extract, 0.1-2% of 1, 2-hexanediol, 0.1-0.5% of p-hydroxyacetophenone, 0.1-0.5% of phenoxyethanol, 0.001-0.1% of alkanna tinctoria root extract, and the balance of deionized water, wherein the total amount is 100%.
2. The composition for skin rejuvenation as claimed in claim 1 wherein said composition comprises the following raw materials in weight percent:
0.1-0.3% of xanthan gum, 0.1-0.3% of sodium hyaluronate, 5-15% of glycerol, 0.3-1% of PEG-60 hydrogenated castor oil, 0.2-1% of recombinant collagen, 0.1-0.5% of licorice root extract, 0.1-0.5% of centella asiatica extract, 0.2-0.5% of 1, 2-hexanediol, 0.1-0.3% of p-hydroxyacetophenone, 0.1-0.3% of phenoxyethanol, 0.001-0.01% of alkanna tinctoria root extract and the balance of deionized water, wherein the total amount is 100%.
3. The composition for skin rejuvenation as defined in claim 1 wherein said recombinant collagen is not less than 95% pure.
4. The composition for skin rejuvenation as claimed in claim 1 wherein said licorice root extract is glycyrrhetinic acid monoglucuronide.
5. The composition for skin rejuvenation as claimed in claim 1 wherein said centella asiatica extract is prepared by a process comprising the steps of:
weighing a certain mass of centella asiatica, leaching with 2-3 times of 90-95% ethanol for three times, each time for 10-20min, combining leaching solutions, concentrating at 45-55 ℃, and drying to obtain powder.
6. The composition for skin rejuvenation as claimed in claim 1 wherein said source of alkannin root extract is high purity alkannin prepared using example 3 of chinese patent 201510881298.6.
7. A process for the preparation of a composition for skin rejuvenation as claimed in any one of claims 1 to 6 which comprises the steps of:
adding carbomer, xanthan gum, sodium hyaluronate and glycerol into water, stirring for dissolving, heating, stirring for dissolving completely, cooling, adding PEG-60 hydrogenated castor oil, recombinant collagen, Glycyrrhrizae radix extract, herba Centellae extract, 1, 2-hexanediol, p-hydroxyacetophenone, phenoxyethanol and radix Arnebiae extract, supplementing evaporated deionized water, and stirring completely.
8. The method for preparing a composition for skin rejuvenation as claimed in claim 7 wherein carbomer, xanthan gum, sodium hyaluronate and glycerin are added to water and dissolved with stirring, heated to 80-90 ℃ and stirred to dissolve completely, and after cooling to 40-50 ℃, PEG-60 hydrogenated castor oil, recombinant collagen, licorice root extract, centella asiatica extract, 1, 2-hexanediol, p-hydroxyacetophenone, phenoxyethanol, and Boragina root extract are added.
9. Use of a composition according to any one of claims 1 to 6 for the preparation of a cosmetic product for skin repair.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115487348A (en) * | 2022-09-23 | 2022-12-20 | 广东粤港澳大湾区黄埔材料研究院 | Composition containing recombinant humanized collagen and preparation method and application thereof |
| CN116098838A (en) * | 2023-02-09 | 2023-05-12 | 山东大学 | Skin repair composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111329828A (en) * | 2020-04-30 | 2020-06-26 | 南京苗邦美业企业管理有限公司 | Essence for removing marks |
| CN112274459A (en) * | 2020-10-30 | 2021-01-29 | 广州市妆妍生物技术有限公司 | Moisture mask and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111329828A (en) * | 2020-04-30 | 2020-06-26 | 南京苗邦美业企业管理有限公司 | Essence for removing marks |
| CN112274459A (en) * | 2020-10-30 | 2021-01-29 | 广州市妆妍生物技术有限公司 | Moisture mask and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115487348A (en) * | 2022-09-23 | 2022-12-20 | 广东粤港澳大湾区黄埔材料研究院 | Composition containing recombinant humanized collagen and preparation method and application thereof |
| CN116098838A (en) * | 2023-02-09 | 2023-05-12 | 山东大学 | Skin repair composition and application thereof |
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