CN113143837A - Anti-aging skin-tendering composition and preparation method thereof - Google Patents
Anti-aging skin-tendering composition and preparation method thereof Download PDFInfo
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- CN113143837A CN113143837A CN202110168731.7A CN202110168731A CN113143837A CN 113143837 A CN113143837 A CN 113143837A CN 202110168731 A CN202110168731 A CN 202110168731A CN 113143837 A CN113143837 A CN 113143837A
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Abstract
The invention discloses an anti-aging skin-tendering composition and a preparation method thereof, wherein the anti-aging skin-tendering composition comprises the following components in parts by weight: the composition comprises a component A containing 0.1-1 part of thickening agent and 5-10 parts of water, a component B containing 0.5-5 parts of solubilizer, 1-12 parts of organic solvent and 0.1-2 parts of antioxidant, a component C containing 15-40 parts of humectant and 15-70 parts of water, and a component D containing 1-16 parts of skin conditioner, wherein the skin conditioner contains honey, royal jelly and oat peptide, and has excellent anti-aging and skin-tendering effects.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging skin-tendering composition and a preparation method thereof.
Background
The skin is an important organ covering the surface of the human body and is composed of the epidermis, dermis, subcutaneous tissue and the appendages of the skin. Skin is a natural barrier between the external environment and the body, and protects organs in the body from temperature and humidity changes, and from the external environment (e.g., ultraviolet rays, pollutants, etc.), however, the protective effect of skin is limited, and when the external influence exceeds a certain degree, skin aging becomes a necessity.
Skin aging is a phenomenon of skin aging caused by natural factors or non-natural factors, and is generally a result of combined action of natural aging and photoaging factors. After birth, the skin tissue of a person is developed increasingly, the function of the person is active gradually, and the person starts to degenerate when the person reaches a certain age, and the degeneration is gradually performed unconsciously. The growth period of skin tissues generally ends at about 25 years old, which is called as 'skin bend angle' by some people, since the growth and aging of the skin tissues are carried out simultaneously, the skin elastic fibers become thicker gradually, and the skin aging is slowly and obviously in the early aging period of 40-50 years, but the aging degree varies from person to person. The photoaging is mainly caused by that active oxygen free radicals are generated in the skin under the irradiation of ultraviolet rays, and the oxygen free radicals cause collagen to be crosslinked, so that the skin loses elasticity and wrinkles are generated. On the other hand, free radicals cause damage to proteins, DNA, etc., and also have a pro-apoptotic effect, reacting with proteins to form brown spots, producing pigmentation, causing premature aging of the skin.
Skin aging is characterized by rough surface, wrinkle formation, skin laxity and pigment imbalance in appearance, and can be expressed by the changes of various physicochemical indexes and comprehensive indexes such as skin chromaticity, glossiness, roughness, water content, elasticity, wrinkle quantity and the like, and can directly influence the appearance and function of skin.
There are many current methods of treating skin aging, both non-surgical and surgical. Non-surgical methods including drug therapy, chemical exfoliation, microwave therapy, cosmetics, enzymes, etc., can be used for light and moderate facial wrinkles; the drug therapy mainly regulates the biological activity of skin cells to improve the skin nutrition condition. Among them, cosmetics are widely accepted as one of daily consumer products by the general public due to their convenience in use and low price. However, many commercially available skin-rejuvenating cosmetics have disadvantages such as insignificant efficacy and susceptibility to side effects such as skin diseases.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides an anti-aging skin-tendering composition and a preparation method thereof.
The invention provides an anti-aging skin-tendering composition, which comprises the following components in parts by weight:
a component a comprising: 0.1-1 part of thickening agent and 5-10 parts of water;
a component B comprising: 0.5-5 parts of solubilizer, 1-12 parts of organic solvent and 0.1-2 parts of antioxidant;
a component C comprising: 15-40 parts of a humectant and 15-70 parts of water;
a component D comprising: 1-16 parts of a skin conditioner;
the skin conditioner comprises honey, royal jelly and oat peptide.
The anti-aging skin-tendering composition provided by the embodiment of the invention has at least the following beneficial effects: the anti-aging skin-tendering composition is added with a skin conditioner comprising honey and royal jelly, wherein the main components of the honey are fructose and glucose, and the honey contains protein, enzyme, organic acid, multiple vitamins and mineral substances, has good permeability, can promote skin metabolism, has excellent moisturizing capability, can moisturize skin, nourish skin, enhance skin elasticity, reduce wrinkle generation, eliminate pigmentation, enable the skin to be fine and smooth, and is a high-quality product for delaying skin aging; the royal jelly not only contains protein, a plurality of amino acids, vitamins, enzymes and a plurality of bioactive substances, but also contains a unique unsaturated fatty acid-royal jelly acid (10-hydroxydecenoic acid), so that the royal jelly can eliminate free radicals, has very strong antioxidation and anti-aging effects, and cell growth factors in the royal jelly can promote cell division and propagation and revive aging cells; the oat peptide is a peptide existing in oat, can effectively inhibit protease activity, has an antioxidant effect, can provide nutrition for skin, condition the skin, efficiently moisturize the skin, reduce skin roughness, has a permeation-assisting effect, helps the skin to better absorb other nutrients, and can achieve a very good synergistic effect by matching with honey and royal jelly; in addition, under the condition that the honey and the royal jelly contain partially unsaturated acid, the antioxidant is added into the formula to ensure that the raw materials are not oxidized and ensure the effectiveness of the efficacy of the raw materials; in addition, the moisturizing effect of the composition is improved by adding the moisturizing agent, and meanwhile, the wet, smooth and warm skin feeling is provided, and the use experience of a user is improved. Through the synergistic cooperation of the raw material components, the composition can achieve the effective anti-aging and skin-tendering effects, and is safe and reliable.
In some embodiments of the invention, the thickener is selected from at least one of polyacrylate crosspolymer-6, carbomer, hydroxyethyl cellulose, xanthan gum, acrylic acid/C10-30 alkanol acrylate crosspolymer.
In some embodiments of the invention, the solubilizing agent is selected from at least one of PPG-26-butyether-26, polysorbate-20, PEG-40 hydrogenated castor oil.
In some embodiments of the invention, the antioxidant is selected from at least one of tocopheryl acetate, butylated hydroxytoluene, sodium metabisulfite, pentaerythritol tetrakis (di-tert-butylhydroxyhydrocinnamate) ester.
In some embodiments of the invention, the humectant is selected from at least one of glycerin, butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, polyglycerol-3, methyl gluceth-20, polyethylene glycol-8, glyceryl polyether-26; preferably, the humectant is selected from the group consisting of glycerin, 1, 2-hexanediol, polyglycerol-3, methyl gluceth-20; further preferably, the humectant is selected from (1-3) by mass: (1-2): (1-3): (1-3) glycerin, 1, 2-hexanediol, polyglycerol-3, and methyl glucitol polyether-20.
In some embodiments of the invention, the skin conditioner further comprises at least one of hexapeptide-1, carnosine, asiaticoside, agave stem extract, citric acid, oat beta-glucan, bioglycan-1, inositol; preferably, the skin conditioner is prepared from the following components in a mass ratio of (1-3): (1-5): (1-5): (1-3): (0.1-0.5): (0.1-0.5) a mixture of avenin, honey, royal jelly, hexapeptide-1, asiaticoside and citric acid. Wherein, hexapeptide-1 can promote the growth of collagen cells and fibroblasts, slow down the force of muscle contraction, relax muscles, reduce the occurrence of dynamic wrinkles and eliminate fine wrinkles; asiaticoside can promote proliferation of fiber cell and synthesis of collagen.
In some embodiments of the present invention, the organic solvent is selected from at least one of ethanol, propylene glycol, dipropylene glycol.
In some embodiments of the present invention, the B component further comprises 0.01 to 0.5 parts of a fragrance.
In some embodiments of the invention, the D component further comprises 0.2-0.8 parts of preservative and/or 0.00001-0.2 parts of colorant; preferably, the preservative is selected from at least one of phenoxyethanol/ethylhexyl glycerin, methylparaben, sodium benzoate, chlorphenesin, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate, and the colorant is selected from at least one of caramel color, CI 14700, CI 15985, and CI 19140. Further preferably, the colorant is a combination of caramel color and CI 14700, and specifically a mass ratio of 1: caramel color of (0.1-1) and CI 14700. In addition, in the case of adding the preservative, the adding proportion of the preservative in the anti-aging and skin-tendering composition needs to be controlled to be less than 0.01 percent.
In a second aspect of the present invention, there is provided a method for preparing the anti-aging skin-tendering composition provided in the first aspect of the present invention, comprising the steps of:
s1, mixing the components in the component A, and standing for 30-40 min to obtain a mixed solution A;
s2, mixing the components in the component B, and stirring uniformly to obtain a mixed solution B;
s3, mixing each component in the component C with the mixed solution A, heating to 85-95 ℃, uniformly stirring, and then homogenizing;
s4, cooling the material processed in the step S3 to 35-45 ℃, adding the components of the component D and the mixed solution B, stirring uniformly and fully dissolving, and then filtering.
In step S2, the stirring speed can be controlled at 40-60 rpm, and the stirring time is 10-20 min.
In step S3, before homogenizing, the stirring speed can be controlled at 50-70 rpm for 5-10 min. The homogenizing treatment can be performed at 1500-2500 rpm for 3-8 min. After the homogenization treatment is finished, the mixture can be continuously stirred for 20-40 min at the speed of 50-80 rpm. The filtering treatment can be carried out by adopting a 300-mesh filter screen.
Drawings
The invention is further described with reference to the following figures and examples, in which:
FIG. 1 is a graph showing the change of the rate of increase in skin moisture content at various stages of application of the anti-aging skin-rejuvenating composition according to the examples;
FIG. 2 is a graph showing the variation of the skin elasticity increase rate of the facial wrinkle region at different stages of a subject using the anti-aging skin-rejuvenating composition according to each example in application example;
FIG. 3 is a graph showing the change in the skin elasticity increase rate of the non-wrinkled area of the face at different stages after the subjects used the anti-aging and skin-rejuvenating composition according to the examples in application example.
Detailed Description
The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention.
Example 1
The embodiment provides an anti-aging and skin-tendering composition, which comprises the following components in parts by weight: the component A comprises: 10 parts of water and 0.1 part of thickening agent; and B component: 0.5 part of solubilizer, 1 part of organic solvent, 0.1 part of antioxidant and 0.01 part of aromatic; and C, component C: 70 parts of water and 15 parts of humectant; and (D) component: 1 part of skin conditioner, 0.2 part of preservative and 0.00001 part of colorant.
Wherein, the thickening agent adopts polyacrylate cross-linked polymer-6; the solubilizer is PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil; the organic solvent adopts ethanol; the antioxidant is selected from tocopherol acetate; the aromatic is essence; the humectant is prepared from the following components in percentage by mass of 1: 1: 1: 1 of glycerol, 1, 2-hexanediol, polyglycerol-3 and methyl gluceth-20; the skin conditioner is prepared from the following components in a mass ratio of 1: 1: 1: 1: 0.1: 0.1 parts of oat peptide, honey, royal jelly, hexapeptide-1, asiaticoside and citric acid; the antiseptic is phenoxyethanol/ethylhexyl glycerol; the colorant is prepared from the following components in percentage by mass of 1: caramel color of 0.1 and CI 14700.
The preparation method of the anti-aging skin-tendering composition comprises the following steps:
s1, mixing the components in the component A, and standing for 30min to obtain a mixed solution A;
s2, mixing the components in the component B, stirring at 40rpm for 20min, and stirring uniformly to obtain a mixed solution B;
s3, adding the components in the component C and the mixed solution A into an emulsification main pot, heating to 85-90 ℃, and stirring at the speed of 50rpm for 10min to stir uniformly; then homogenizing at 1500rpm for 8 min; stirring at 50rpm for 40 min;
s4, cooling the materials in the emulsification main pot processed in the step S3 to 35-40 ℃, adding the components of the component D and the mixed liquid B, stirring at 30rpm for 40min to uniformly and fully dissolve the components, and filtering by using a 300-mesh filter screen to obtain the anti-aging and skin-tendering composition.
Example 2
The embodiment provides an anti-aging and skin-tendering composition, which comprises the following components in parts by weight: the component A comprises: 8 parts of water and 1 part of thickening agent; and B component: 5 parts of solubilizer, 12 parts of organic solvent, 2 parts of antioxidant and 0.5 part of aromatic; and C, component C: 15 parts of water and 40 parts of humectant; and (D) component: 16 parts of skin conditioner, 0.8 part of preservative and 0.02 part of colorant.
Wherein, the thickening agent adopts polyacrylate cross-linked polymer-6; the solubilizer is PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil; the organic solvent adopts ethanol; the antioxidant is selected from tocopherol acetate; the aromatic is essence; the humectant is 3: 2: 3: 3 of glycerol, 1, 2-hexanediol, polyglycerol-3 and methyl gluceth-20; the skin conditioner is prepared from the following components in a mass ratio of 1: 1: 1: 3: 0.5: 0.5 parts of oat peptide, honey, royal jelly, hexapeptide-1, asiaticoside and citric acid; the antiseptic is phenoxyethanol/ethylhexyl glycerol; the colorant is prepared from the following components in percentage by mass of 1: caramel color of 1 and CI 14700.
The preparation method of the anti-aging skin-tendering composition comprises the following steps:
s1, mixing the components in the component A, and standing for 35min to obtain a mixed solution A;
s2, mixing the components in the component B, stirring for 15min at the speed of 50rpm, and uniformly stirring to obtain a mixed solution B;
s3, adding the components in the component C and the mixed solution A into an emulsification main pot, heating to 85-90 ℃, and stirring at the speed of 60rpm for 8min to stir uniformly; then homogenizing at 2000rpm for 5 min; stirring at 70rpm for 30 min;
s4, cooling the materials in the emulsification main pot processed in the step S3 to 40-45 ℃, adding the components of the component D and the mixed liquid B, stirring at 40rpm for 30min to uniformly and fully dissolve, and filtering with a 300-mesh filter screen to obtain the anti-aging and skin-tendering composition.
Example 3
The embodiment provides an anti-aging and skin-tendering composition, which comprises the following components in parts by weight: the component A comprises: 10 parts of water and 0.5 part of thickening agent; and B component: 2 parts of solubilizer, 8 parts of organic solvent, 1 part of antioxidant and 0.05 part of aromatic; and C, component C: 33 parts of water and 30 parts of humectant; and (D) component: 15 parts of skin conditioner, 0.5 part of preservative and 0.1 part of colorant.
Wherein, the thickening agent adopts polyacrylate cross-linked polymer-6; the solubilizer is PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil; the organic solvent adopts ethanol; the antioxidant is selected from tocopherol acetate; the aromatic is essence; the humectant is prepared from the following components in percentage by mass: 1: 2: 3 of glycerol, 1, 2-hexanediol, polyglycerol-3 and methyl gluceth-20; the skin conditioner comprises 3 mass percent of: 5: 5: 1: 0.1: 0.1 parts of oat peptide, honey, royal jelly, hexapeptide-1, asiaticoside and citric acid; the antiseptic is phenoxyethanol/ethylhexyl glycerol; the colorant is prepared from the following components in percentage by mass of 1: caramel color 0.5 and CI 14700.
The preparation method of the anti-aging skin-tendering composition comprises the following steps:
s1, mixing the components in the component A, and standing for 40min to obtain a mixed solution A;
s2, mixing the components in the component B, stirring at the speed of 60rpm for 10min, and stirring uniformly to obtain a mixed solution B;
s3, adding the components in the component C and the mixed solution A into an emulsification main pot, heating to 90-95 ℃, and stirring at the speed of 70rpm for 5min to stir uniformly; then homogenizing at 2500rpm for 3 min; stirring at 80rpm for 20 min;
s4, cooling the materials in the emulsification main pot processed in the step S3 to 40-45 ℃, adding the components of the component D and the mixed liquid B, stirring at the speed of 60rpm for 20min to uniformly and fully dissolve the components, and filtering by using a 300-mesh filter screen to obtain the anti-aging and skin-tendering composition.
Example 4
The embodiment provides an anti-aging and skin-tendering composition, which comprises the following components in parts by weight: the component A comprises: 10 parts of water and 0.5 part of thickening agent; and B component: 2 parts of solubilizer, 8 parts of organic solvent, 1 part of antioxidant and 0.05 part of aromatic; and C, component C: 33 parts of water and 30 parts of humectant; and (D) component: 15 parts of skin conditioner, 0.5 part of preservative and 0.1 part of colorant.
Wherein, the thickening agent adopts polyacrylate cross-linked polymer-6; the solubilizer is PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil; the organic solvent adopts ethanol; the antioxidant is selected from tocopherol acetate; the aromatic is essence; the humectant is prepared from the following components in percentage by mass: 1: 2: 3 of glycerol, 1, 2-hexanediol, polyglycerol-3 and methyl gluceth-20; the skin conditioner comprises 3 mass percent of: 5: 5: 1.2 of oat peptide, honey, royal jelly and water; the antiseptic is phenoxyethanol/ethylhexyl glycerol; the colorant is prepared from the following components in percentage by mass of 1: caramel color 0.5 and CI 14700.
The preparation method of the anti-aging skin-tendering composition comprises the following steps:
s1, mixing the components in the component A, and standing for 40min to obtain a mixed solution A;
s2, mixing the components in the component B, stirring at the speed of 60rpm for 10min, and stirring uniformly to obtain a mixed solution B;
s3, adding the components in the component C and the mixed solution A into an emulsification main pot, heating to 90-95 ℃, and stirring at the speed of 70rpm for 5min to stir uniformly; then homogenizing at 2500rpm for 3 min; stirring at 80rpm for 20 min;
s4, cooling the materials in the emulsification main pot processed in the step S3 to 40-45 ℃, adding the components of the component D and the mixed liquid B, stirring at the speed of 60rpm for 20min to uniformly and fully dissolve the components, and filtering by using a 300-mesh filter screen to obtain the anti-aging and skin-tendering composition.
Comparative example 1
The embodiment provides an anti-aging and skin-tendering composition, which comprises the following components in parts by weight: the component A comprises: 10 parts of water and 0.5 part of thickening agent; and B component: 2 parts of solubilizer, 8 parts of organic solvent, 1 part of antioxidant and 0.05 part of aromatic; and C, component C: 33 parts of water and 30 parts of humectant; and (D) component: 15 parts of skin conditioner, 0.5 part of preservative and 0.1 part of colorant.
Wherein, the thickening agent adopts polyacrylate cross-linked polymer-6; the solubilizer is PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil; the organic solvent adopts ethanol; the antioxidant is selected from tocopherol acetate; the aromatic is essence; the humectant is prepared from the following components in percentage by mass: 1: 2: 3 of glycerol, 1, 2-hexanediol, polyglycerol-3 and methyl gluceth-20; the skin conditioner comprises 3 mass percent of: 5: 5: 1: 0.1: 0.1 parts of water, honey, royal jelly, hexapeptide-1, asiaticoside and citric acid; the antiseptic is phenoxyethanol/ethylhexyl glycerol; the colorant is prepared from the following components in percentage by mass of 1: caramel color 0.5 and CI 14700.
The preparation method of the anti-aging skin-tendering composition comprises the following steps:
s1, mixing the components in the component A, and standing for 40min to obtain a mixed solution A;
s2, mixing the components in the component B, stirring at the speed of 60rpm for 10min, and stirring uniformly to obtain a mixed solution B;
s3, adding the components in the component C and the mixed solution A into an emulsification main pot, heating to 90-95 ℃, and stirring at the speed of 70rpm for 5min to stir uniformly; then homogenizing at 2500rpm for 3 min; stirring at 80rpm for 20 min;
s4, cooling the materials in the emulsification main pot processed in the step S3 to 40-45 ℃, adding the components of the component D and the mixed liquid B, stirring at the speed of 60rpm for 20min to uniformly and fully dissolve the components, and filtering by using a 300-mesh filter screen to obtain the anti-aging and skin-tendering composition.
Test examples
The anti-aging skin-tendering composition prepared in each example is subjected to application test tests, and the application test tests are as follows:
testing the environmental temperature: 25 ± 1 ℃, relative humidity: 50 +/-5%. The effective volunteers are 100, 50 men and 50 women, and the age is 30-45 years old. The test method comprises the following steps: the subjects were divided into 5 groups of 20 subjects each, 10 men and 10 women, and each group of subjects was given the anti-aging and skin-rejuvenating composition of examples 1 to 4 and comparative example 1 above all over the face for 12 weeks, 1 time per night, and no other skin care product was used during the test period. The subjects were evaluated for stratum corneum moisture content, skin elasticity, visual wrinkles at different stages, and were allowed to self-evaluate. The specific test time points are respectively as follows: before use (W0), 2 weeks after use (W2), 4 weeks (W4), 8 weeks (W8), 12 weeks (W12). The specific evaluation methods and results are as follows:
evaluation of moisture content of skin stratum corneum: skin moisture content was analyzed using a skin moisture tester Corneometer CM 825 to measure skin capacitance values. Higher test values indicate higher stratum corneum moisture content. The measurement is completed by the same measurer for 3 times, the average value of the measurement is taken, the increase rate is calculated by taking the skin moisture content measured before use as a reference after statistics, and the obtained result is shown in figure 1.
Evaluation of skin elasticity: the skin elasticity of the facial wrinkle and non-wrinkle areas was measured with the instrument Cutomer MPA 580. The Cutomer is a testing instrument designed based on suction and stretching principles, the principle is that negative pressure pulls skin to cause deformation, the capability of the skin to recover deformation is measured, an elastic recovery parameter RE/R0 is used for representing the elastic characteristic of the skin, each testing point is repeatedly measured for 3 times and then averaged, the increase rate is calculated by taking the measured skin elasticity value before use as a reference after statistics, and the testing result is shown in fig. 2 and fig. 3.
Evaluation of wrinkles by visual inspection: the scoring staff scores wrinkles at 4 positions of canthus wrinkles, glabellar wrinkles, forehead wrinkles and perioral wrinkles of the subject. The scoring standard is divided into 1-10 grades, the higher the score is, the more serious the wrinkles are, the score is statistically calculated to be an average value according to the scoring result, the effect is reflected in the descending trend of scoring in the use process, the lower the score is, the better the effect is, and the obtained results are shown in tables 1-4.
TABLE 1 Ocular Angle wrinkle score
TABLE 2 intereyebrow wrinkle score
TABLE 3 forehead wrinkle score
TABLE 4 perioral wrinkle score
Self-assessment: the subjects evaluated their skin allergy in terms of the whole facial area, wrinkles, elasticity, firmness and water improvement and the examples according to the self-evaluation table, and counted in terms of the ratio of the number of persons evaluated, and the results are shown in tables 5 to 9.
Table 5 self-assessment improvement in population ratio of subjects using the anti-aging skin rejuvenation composition of example 1
Table 6 self-assessment of the population ratio for improvement in subjects using the anti-aging skin rejuvenation composition of example 2
Table 7 self-assessment of the population ratio for improvement in subjects using the anti-aging skin rejuvenation composition of example 3
Table 8 self-assessment of the population ratio for improvement in subjects using the anti-aging skin rejuvenation composition of example 4
TABLE 9 self-assessment improvement population ratio of subjects using the anti-aging skin rejuvenation composition of comparative example 1
From the application test results, after the subjects use the anti-aging and skin-rejuvenating compositions of examples 1-4 and comparative example 1 for 2-12 weeks, the moisture content of the facial skin is improved, the skin elasticity is obviously increased, and the wrinkles on the face are obviously reduced, wherein the addition amount of the skin conditioner in the anti-aging and skin-rejuvenating composition of example 1 is the least, so the effect is relatively the worst; the addition amount of the skin conditioning agent and the humectant in the embodiment 2 is high, and although the addition ratio of the honey to the royal jelly is low, the ratio of other components of the skin conditioning agent is increased, so that the overall effect of the composition in the embodiment 2 is good; compared with examples 1,2 and 4 and comparative example 1, the anti-aging and skin-tendering composition of example 3 has more obvious effect, reasonable proportion addition amount and best effect when used by a subject; as can be seen from the comparison of the effects of comparative example 1 and examples 2 and 3, the combination of oat peptide, honey and royal jelly has a synergistic effect when used as a skin conditioner.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (10)
1. The anti-aging skin-tendering composition is characterized by comprising the following components in parts by weight:
a component a comprising: 0.1-1 part of thickening agent and 5-10 parts of water;
a component B comprising: 0.5-5 parts of solubilizer, 1-12 parts of organic solvent and 0.1-2 parts of antioxidant;
a component C comprising: 15-40 parts of a humectant and 15-70 parts of water;
a component D comprising: 1-16 parts of a skin conditioner;
the skin conditioner comprises honey, royal jelly and oat peptide.
2. The anti-aging skin-tendering composition according to claim 1, wherein the thickener is at least one selected from polyacrylate crosspolymer-6, carbomer, hydroxyethyl cellulose, xanthan gum, acrylic acid/C10-30 alkanol acrylate crosspolymer.
3. The anti-aging skin rejuvenation composition as claimed in claim 1 wherein the solubilizing agent is at least one selected from PPG-26-butyether-26, polysorbate-20, PEG-40 hydrogenated castor oil.
4. The anti-aging skin-tendering composition according to claim 1, wherein the antioxidant is selected from at least one of tocopherol acetate, butylated hydroxytoluene, sodium metabisulfite, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) ester.
5. The anti-aging skin rejuvenation composition as claimed in claim 1 wherein the humectant is selected from at least one of glycerin, butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, polyglycerin-3, methyl gluceth-20, polyethylene glycol-8, glyceryl polyether-26; preferably, the humectant is selected from the group consisting of glycerin, 1, 2-hexanediol, polyglycerol-3, methyl gluceth-20; further preferably, the humectant is selected from (1-3) by mass: (1-2): (1-3): (1-3) glycerin, 1, 2-hexanediol, polyglycerol-3, and methyl glucitol polyether-20.
6. The anti-aging skin rejuvenation composition as claimed in claim 1 wherein the skin conditioning agent further comprises at least one of hexapeptide-1, carnosine, asiaticoside, agave stem extract, citric acid, oat beta-glucan, bioglycan-1, inositol; preferably, the skin conditioner is prepared from the following components in a mass ratio of (1-3): (1-5): (1-5): (1-3): (0.1-0.5): (0.1-0.5) a mixture of avenin, honey, royal jelly, hexapeptide-1, asiaticoside and citric acid.
7. The anti-aging skin-tendering composition according to claim 1, wherein the organic solvent is at least one selected from ethanol, propylene glycol and dipropylene glycol.
8. The anti-aging skin-tendering composition according to claim 1, characterized in that the component B further comprises 0.01-0.5 parts of aromatic.
9. The anti-aging skin rejuvenation composition as claimed in any one of claims 1 to 8 wherein the D component further comprises 0.2 to 0.8 parts of a preservative and/or 0.00001 to 0.2 parts of a colorant; preferably, the preservative is selected from at least one of phenoxyethanol/ethylhexyl glycerin, methylparaben, sodium benzoate, chlorphenesin, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate, and the colorant is selected from at least one of caramel color, CI 14700, CI 15985, and CI 19140.
10. A method of preparing an anti-aging skin rejuvenation composition as claimed in any one of claims 1 to 9 which comprises the steps of:
s1, mixing the components in the component A, and standing for 30-40 min to obtain a mixed solution A;
s2, mixing the components in the component B, and stirring uniformly to obtain a mixed solution B;
s3, mixing each component in the component C with the mixed solution A, heating to 85-95 ℃, uniformly stirring, and then homogenizing;
s4, cooling the material processed in the step S3 to 35-45 ℃, adding the components of the component D and the mixed solution B, stirring uniformly and fully dissolving, and then filtering.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115612147A (en) * | 2022-11-09 | 2023-01-17 | 惠州市鑫亚凯立科技有限公司 | Optical fluorine release film with multilayer structure and manufacturing method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055282A (en) * | 2015-08-18 | 2015-11-18 | 北京神州瑞霖环保科技有限公司 | Skin-care composition with anti-aging and skin rejuvenation functions and preparation method of skin-care composition |
| CN105748383A (en) * | 2016-02-04 | 2016-07-13 | 广州静美化妆品科技有限公司 | Royal jelly extract-containing anti-aging skin cream and preparation method thereof |
| CN107737058A (en) * | 2017-12-01 | 2018-02-27 | 绿馨颜（惠州）生物科技有限公司 | A kind of gold moisture retention water of biological carbohydrate gum 1 and preparation method thereof |
| CN109875909A (en) * | 2019-04-12 | 2019-06-14 | 广州昀东生物科技有限公司 | A kind of anti-ageing effect cosmetic of polypeptides in combination |
| CN110312551A (en) * | 2016-12-22 | 2019-10-08 | Lvmh研究公司 | The cosmetic composition of royal jelly comprising Wei Sanghei bee |
-
2021
- 2021-02-07 CN CN202110168731.7A patent/CN113143837A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055282A (en) * | 2015-08-18 | 2015-11-18 | 北京神州瑞霖环保科技有限公司 | Skin-care composition with anti-aging and skin rejuvenation functions and preparation method of skin-care composition |
| CN105748383A (en) * | 2016-02-04 | 2016-07-13 | 广州静美化妆品科技有限公司 | Royal jelly extract-containing anti-aging skin cream and preparation method thereof |
| CN110312551A (en) * | 2016-12-22 | 2019-10-08 | Lvmh研究公司 | The cosmetic composition of royal jelly comprising Wei Sanghei bee |
| CN107737058A (en) * | 2017-12-01 | 2018-02-27 | 绿馨颜（惠州）生物科技有限公司 | A kind of gold moisture retention water of biological carbohydrate gum 1 and preparation method thereof |
| CN109875909A (en) * | 2019-04-12 | 2019-06-14 | 广州昀东生物科技有限公司 | A kind of anti-ageing effect cosmetic of polypeptides in combination |
Non-Patent Citations (2)
| Title |
|---|
| 娇兰（法国）总公司: "娇兰帝皇蜂姿修复蜜润柔肤水", 《国家药品监督管理局数据查询，网址：HTTPS://WWW.NMPA.GOV.CN/DATASEARCH/SEARCH-RESULT.HTML》 * |
| 宋丽雅等, 北京：中国轻工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115612147A (en) * | 2022-11-09 | 2023-01-17 | 惠州市鑫亚凯立科技有限公司 | Optical fluorine release film with multilayer structure and manufacturing method thereof |
| CN115612147B (en) * | 2022-11-09 | 2023-06-06 | 惠州市鑫亚凯立科技有限公司 | Optical fluorine release film with multilayer structure and manufacturing method thereof |
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Application publication date: 20210723 |