CN114344240A - Hyaluronic acid toning lotion and preparation method thereof - Google Patents
Hyaluronic acid toning lotion and preparation method thereof Download PDFInfo
- Publication number
- CN114344240A CN114344240A CN202210026352.9A CN202210026352A CN114344240A CN 114344240 A CN114344240 A CN 114344240A CN 202210026352 A CN202210026352 A CN 202210026352A CN 114344240 A CN114344240 A CN 114344240A
- Authority
- CN
- China
- Prior art keywords
- parts
- hyaluronic acid
- component
- water
- sodium hyaluronate
- Prior art date
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- Pending
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 84
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 84
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 84
- 239000006210 lotion Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims description 11
- 239000003906 humectant Substances 0.000 claims abstract description 27
- 239000002904 solvent Substances 0.000 claims abstract description 21
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 19
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 19
- 239000002738 chelating agent Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 97
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 92
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 83
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 83
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 82
- 239000000203 mixture Substances 0.000 claims description 71
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 59
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 59
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 53
- 239000000047 product Substances 0.000 claims description 44
- 238000003756 stirring Methods 0.000 claims description 32
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 29
- 235000001855 Portulaca oleracea Nutrition 0.000 claims description 29
- 238000000855 fermentation Methods 0.000 claims description 29
- 230000004151 fermentation Effects 0.000 claims description 29
- 244000146462 Centella asiatica Species 0.000 claims description 28
- 235000004032 Centella asiatica Nutrition 0.000 claims description 28
- 239000002994 raw material Substances 0.000 claims description 26
- 244000234609 Portulaca oleracea Species 0.000 claims description 25
- 235000011187 glycerol Nutrition 0.000 claims description 20
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 18
- 239000011265 semifinished product Substances 0.000 claims description 18
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 17
- 241000206575 Chondrus crispus Species 0.000 claims description 17
- 229940014041 hyaluronate Drugs 0.000 claims description 17
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 16
- 241000186660 Lactobacillus Species 0.000 claims description 16
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 16
- 238000001816 cooling Methods 0.000 claims description 16
- 238000007599 discharging Methods 0.000 claims description 16
- 239000008103 glucose Substances 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 16
- 229940039696 lactobacillus Drugs 0.000 claims description 16
- 229920001285 xanthan gum Polymers 0.000 claims description 16
- 239000000230 xanthan gum Substances 0.000 claims description 16
- 229940082509 xanthan gum Drugs 0.000 claims description 16
- 235000010493 xanthan gum Nutrition 0.000 claims description 16
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 15
- 241000195493 Cryptophyta Species 0.000 claims description 15
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 15
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 15
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 15
- 229960003237 betaine Drugs 0.000 claims description 15
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 15
- 229940101267 panthenol Drugs 0.000 claims description 15
- 235000020957 pantothenol Nutrition 0.000 claims description 15
- 239000011619 pantothenol Substances 0.000 claims description 15
- 229910052700 potassium Inorganic materials 0.000 claims description 15
- 239000011591 potassium Substances 0.000 claims description 15
- SCVVSSZVLZQUDZ-UHFFFAOYSA-N 3-methyl-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound CN1C(NCC=C1)C(=O)O SCVVSSZVLZQUDZ-UHFFFAOYSA-N 0.000 claims description 14
- 230000001804 emulsifying effect Effects 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 14
- 229940087068 glyceryl caprylate Drugs 0.000 claims description 14
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 14
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 13
- -1 caprylyl hydroxamic Chemical compound 0.000 claims description 13
- 229920006037 cross link polymer Polymers 0.000 claims description 13
- 241000206576 Chondrus Species 0.000 claims description 11
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 11
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 10
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 238000007689 inspection Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 238000005086 pumping Methods 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 claims description 5
- 229940100573 methylpropanediol Drugs 0.000 claims description 5
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 5
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims description 3
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 230000003750 conditioning effect Effects 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- 241000235347 Schizosaccharomyces pombe Species 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- 239000000413 hydrolysate Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 241000219304 Portulacaceae Species 0.000 claims 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
- OTPDWCMLUKMQNO-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrimidine Chemical compound C1NCC=CN1 OTPDWCMLUKMQNO-UHFFFAOYSA-N 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 235000019270 ammonium chloride Nutrition 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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- 241000196324 Embryophyta Species 0.000 description 2
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- WDQLRUYAYXDIFW-RWKIJVEZSA-N (2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1 WDQLRUYAYXDIFW-RWKIJVEZSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to hyaluronic acid toning lotion which consists of a skin conditioner, a humectant, a chelating agent, an antioxidant and a solvent. Hyaluronic acid, an acidic mucopolysaccharide, has high moisture retention, viscoelasticity, biocompatibility, and other properties. The product produced according to the technical scheme of the invention is suitable for use after face cleaning, and is used for treating alternate rough and dry skin due to seasons; become tired and dull due to excessive stress; the original balance of the skin is damaged due to long-distance travel and long-time sunburn; has good cosmetic effect when aging occurs due to aging or hormone change.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to hyaluronic acid toning lotion and a preparation method thereof.
Background
The water-like cosmetics refer to transparent liquid products with water, alcohol or water and alcohol solution as matrix, such as perfume, cosmetic water, cold perm water, skin care water, hair growth promoting water, itching relieving water, deodorant water, tinea pedis water, various natural plant lotions and the like, which are required to keep bright color, clear and transparent, and have no impurities. Namely, the lotion belongs to one of water-like cosmetics, and is generally used by applying a proper amount of lotion to the facial skin after cleansing the face and gently massaging the skin until the lotion is absorbed.
In the prior art, the invention with the publication number of CN105596224A discloses a preparation method of small molecular group water toning lotion, discloses a preparation method, and provides small molecular group water toning lotion different from the prior toning lotion by changing solvent water in the toning lotion or solvent water and medium water in the synthesis process of nutrient components in the toning lotion and irrigation water in the culture and cultivation process of natural nutrient components, and improves the moisture retention and skin protection capability of the toning lotion by utilizing six functions of the small molecular group water, such as strong dissolving power, diffusion power, seepage power, emulsifying power, cleaning power, metabolic power and the like. The principle utilized by the technical scheme is that the difference between the small molecular group water toning lotion and the common toning lotion is as follows: the small molecular group water replaces solvent water in the makeup water or replaces solvent water and medium water in the synthesis process of nutrient components in the makeup water and irrigation water in the process of cultivating and cultivating native plants of natural components.
The publication number CN104055725A discloses a nanometer functional travel lotion, which is a nanometer traditional Chinese medicine element anion far infrared anti-electromagnetic wave anti-allergy skin-refreshing travel lotion, radix aucklandiae has the effects of relieving itching, dispelling rash, refreshing, overflowing fragrance, relieving summer heat, radix lithospermi has the effects of removing acne stains, preventing pachylosis, preventing angelica dahurica from being bitten by mosquitoes, diminishing inflammation, relieving pain, relieving swelling, refreshing, preventing mint from getting refreshed, preventing sleepiness, refreshing and refreshing, royal jelly is nutritious, sun-proof, anti-ultraviolet, skin-beautifying, spina date seed has the effects of diminishing inflammation, relieving itching, deodorizing, resisting allergy, and tendering skin. The technical scheme makes a product formula with specific functions and a preparation scheme aiming at the requirements of people in travel and the influence of life and environment in travel on human bodies. .
The publication number CN105963174A invention names an antiallergic astringent and a cosmetic containing the astringent and a using method thereof, the technical scheme provides the antiallergic astringent, and the antiallergic astringent comprises: cactus extract, energy ore compound, propylene glycol, disodium edetate and water. The technical scheme can also comprise: human epidermal growth factor hEGF, vascular endothelial growth factor VEGF, fibroblast growth factor FGF, transforming growth factor-beta 1 TGF-beta 1, transforming growth factor-beta 2 TGF-beta 2, insulin-like growth factor IGF-1, insulin-like growth factor IGF-2 and other biological preparations.
At present, different types and different effects of lotion are designed for people with different functions and different living environments in the makeup industry, and it is very necessary to design a mild lotion suitable for most people. Therefore, it is an objective need to provide a fixed formulation of hyaluronic acid lotion, which is convenient for the consumer to use and provides the desired cosmetic effect.
Disclosure of Invention
In order to overcome the defects of the existing skin care products, the invention aims to provide hyaluronic acid toning lotion; the invention also aims to provide a preparation method of the hyaluronic acid toning lotion.
Hyaluronic acid, an acidic mucopolysaccharide, has high moisture retention, viscoelasticity, biocompatibility, and other properties. The existing hyaluronic acid has four sources, namely, the hyaluronic acid is directly extracted from animals, such as bulls eyes and cockscomb; secondly, biological fermentation extraction, which is also the current main method; thirdly, treating common macromolecular hyaluronic acid by using hyaluronidase with an animal structure; fourthly, treating the common macromolecular hyaluronic acid by the human hyaluronidase.
The hyaluronic acid toning lotion is realized by the following technical scheme.
The hyaluronic acid toning lotion disclosed by the invention is composed of a skin conditioner, a humectant, a chelating agent, an antioxidant and a solvent.
Wherein the skin conditioning agent is selected from the group consisting of water, butylene glycol, purslane (Portulaca oleracea) extract, a mixture consisting of methyl propylene glycol, caprylic hydroxamic acid, glyceryl caprylate, a mixture consisting of water, 1, 2-hexanediol, xanthan gum, caprylyl glycol, butylene glycol, glucose, sodium hyaluronate, Chondrus crispus (Chondrus crispus) extract, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, sodium acetylated hyaluronate, hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, potassium hyaluronate, tetrahydromethyl pyrimidine carboxylic acid, a mixture consisting of Schizosaccharomyces cerevisiae fermentation product filtrate, 1, 2-hexanediol, p-hydroxyacetophenone, a mixture consisting of lactobacillus/algae extract fermentation product and dipropylene glycol, panthenol, or a mixture consisting of water, a grass (CENTELLAASIATICA) extract, a mixture consisting of water, caprylyl hydroxamic acid, caprylyl caprylate, a mixture consisting of water, 1, 2-hexanediol, sodium hyaluronate, a mixture consisting of caprylyl glycol, xanthan gum, caprylyl glycol, a mixture consisting of water, a mixture of caprylyl hydroxamic acid, a mixture of caprylyl glycol, a mixture of water, a mixture of caprylyl glycol, a mixture of lactobacillus extract, a mixture of glycerin, a mixture of glycerin, a mixture of glycerin, a mixture of glycerin, a mixture of glycerin, a mixture of, One or more of glycerol, 1, 2-hexanediol and p-hydroxyacetophenone.
The humectant is one or more of butanediol, 1, 2-hexanediol, sodium hyaluronate, betaine or hydrolyzed sodium hyaluronate; (ii) a
The chelating agent is EDTA disodium;
the antioxidant is p-hydroxyacetophenone;
the solvent is water.
In the technical scheme of the invention, the skin conditioning agent, the humectant, the chelating agent, the antioxidant and the solvent are all available from the market.
Further, in the technical scheme of the invention, the hyaluronic acid toning lotion comprises the following raw materials in parts by weight:
wherein the skin conditioner is selected from the group consisting of 0.22-0.28 parts of water, 0.22-0.28 parts of butylene glycol, 0.12-0.18 parts of purslane (Portulaca oleracea) extract, a mixture consisting of 0.2-0.5 parts of methyl propylene glycol, 0.03-0.08 parts of caprylyl hydroximic acid, 0.0035-0.0055 parts of caprylic caprylate, a mixture consisting of 0.00080-0.00100 parts of water, 1, 2-hexanediol 0.000022-0.000038 parts of xanthan gum, 0.000010-0.000015 parts of caprylyl glycol, 0.000002-0.000008 parts of butylene glycol 0.0000006-567 parts of glucose 0.00000035-0.00000045 parts of sodium hyaluronate, 0.0180-0.0220 parts of Chondrus crispus (Chondrus) extract, 0.0090-0.0120 parts of hyaluronic acid, 0.015-0.023 of hydroxypropyl trimethyl hyaluronic acid, 0.015-0.023 parts of acetylated hyaluronic acid, 0.0220.022-0.022 0.493 polymer, 0.022-0.493 parts of hyaluronic acid, 0.4 parts of sodium chloride, 0.000015 parts of hyaluronic acid, 0.0000000002-0.0000000022 parts of hydrolyzed sodium hyaluronate, 0.0000000002-0.0000000022 parts of potassium hyaluronate, 0.092-0.18 part of tetrahydro methyl pyrimidine carboxylic acid, 0.092-0.16 part of a yeast fermentation product filtrate, 0.0000042-0.0000062 part of 1, 2-hexanediol and 0.0000032-0.0000045 parts of p-hydroxyacetophenone, 0.065-0.075 part of a lactobacillus/algae extract fermentation product and 0.00026-0.00034 part of dipropylene glycol, 0.00092-0.00105 parts of panthenol, or one or more of water 0.000830-0.000848 parts, 0.000092-0.000108 parts of centella asiatica (CENTELLAASIATICA) extract, 0.000042-0.000056 parts of glycerol, 0.0000065-0.0000075 parts of 1, 2-hexanediol and 0.0000045-0.0000058 parts of p-hydroxyacetophenone.
The humectant is one or more of 3.90-4.10 parts of butanediol, 0.190-0.205 part of 1, 2-hexanediol, 0.0092-0.0105 part of sodium hyaluronate, 0.00092-0.00105 parts of betaine or 0.00092-0.00108 part of hydrolyzed sodium hyaluronate;
the chelating agent is 0.045-0.055 part of EDTA disodium;
the antioxidant is 0.290-0.310 part of p-hydroxyacetophenone;
the solvent is 92.01-96.08 parts of water.
Preferably, in the technical scheme of the invention, the hyaluronic acid lotion comprises the following raw materials in parts by weight:
wherein the skin conditioner is selected from the group consisting of a mixture consisting of 0.24-0.26 parts of water, 0.24-0.26 parts of butylene glycol, 0.14-0.16 parts of purslane (Portulaca oleracea) extract, a mixture consisting of 0.3-0.4 parts of methyl propylene glycol, 0.04-0.06 parts of caprylic hydroxamic acid, 0.003-0.005 parts of caprylic glyceryl caprylate, a mixture consisting of 0.00088-0.00098 parts of water, 0.000025-0.000035 parts of 1, 2-hexanediol, 0.000012-0.000014 parts of xanthan gum, 0.000004-0.000006 parts of caprylyl glycol, 0.0000008-0.0000012 parts of butylene glycol, 23-73 0.00000042 parts of glucose, 0.0185-0.0215 parts of sodium hyaluronate, 0.0095-0115 parts of Chondrus crispus (Chondrus) extract, 0.019-0.465 parts of hydroxypropyl trimethyl hyaluronic acid, 0.019-0.021 parts of hydrolyzed hyaluronic acid, 0.019-0.021, 0.019-0.5 parts of hyaluronic acid, 0.5 parts of hyaluronic acid cross-sodium hyaluronate, 0.0000000009-0.0000000011 parts of hydrolyzed sodium hyaluronate, 0.0000000009-0.0000000011 parts of potassium hyaluronate, 0.095-0.15 part of tetrahydro methyl pyrimidine carboxylic acid, 0.095-0.15 part of schizosaccharomyces cerevisiae fermentation product filtrate, 0.0000048-0.0000 part of 1, 2-hexanediol, 0.0000038-0.0000042 parts of p-hydroxyacetophenone, 0.068-0.072 part of lactobacillus/algae extract fermentation product and 0.00029-0.00031 part of dipropylene glycol, 0.00098-0.00102 parts of panthenol, or one or more of water 0.000835-0.000840 parts, asiatic pennywort (CENTELLAASIATICA) extract 0.000098-0.000102 parts, 0.000048-0.000052 parts of glycerol, 1, 2-hexanediol 0.0000068-0.0000072 parts of p-hydroxyacetophenone, 0.0000048-0.0000 parts of p-hydroxyacetophenone.
The humectant is one or more of 3.95-4.05 parts of butanediol, 0.198-0.202 part of 1, 2-hexanediol, 0.0098-0.0102 parts of sodium hyaluronate, 0.00098-0.00102 parts of betaine or 0.00098-0.00102 parts of hydrolyzed sodium hyaluronate;
the chelating agent is 0.048-0.052 parts of EDTA disodium;
the antioxidant is 0.295-0.305 part of p-hydroxyacetophenone;
the solvent is 94.01-94.03 parts of water.
More preferably, the hyaluronic acid lotion comprises the following components in parts by weight:
wherein the skin conditioner is selected from the group consisting of 0.2485 parts of water, 0.25 part of butylene glycol, 0.15 part of extract of purslane (Portulaca oleracea), 0.348 part of methyl propylene glycol, 0.048 part of caprylyl hydroxamic acid, 0.004 part of glyceryl caprylate, 0.000950275 parts of water, 0.00003 part of 1, 2-hexanediol, 0.000013 parts of xanthan gum, 0.000005 part of caprylyl glycol, 0.000001 part of butylene glycol, 0.0000004 parts of glucose, 0.02 part of sodium hyaluronate, 0.01 part of Chondrus crispus (Chondrus) extract, 0.02 part of hydroxypropyl trimethyl ammonium chloride hyaluronic acid, 0.02 part of hydrolyzed hyaluronic acid, 0.02 part of sodium hyaluronate, 0.000000001 part of hyaluronic acid cross-linked polymer, 0.000000001 part of hydrolyzed sodium hyaluronate, 0.00001 part of potassium hyaluronate, 0.1 part of tetrahydromethyl pyrimidine carboxylic acid, 0.1 part of yeast filtrate, 0.00001 part of dihexyl glycol, 0.000000001 part of ethyl keton hydrolysate, 0.2.00001 part of ethyl keton mixture, 0.07 part of lactobacillus/algae extract fermentation product and 0.0003 part of dipropylene glycol, 0.001 part of panthenol, or one or more of water 0.000838 parts, centella asiatica (CENTELLAASIATICA) extract 0.0001 part, glycerol 0.00005 part, 1, 2-hexanediol 0.000007 part and p-hydroxyacetophenone 0.000005 part.
The humectant is one or more of 4 parts of butanediol, 0.2 part of 1, 2-hexanediol, 0.01 part of sodium hyaluronate, 0.001 part of betaine or 0.001 part of hydrolyzed sodium hyaluronate; (ii) a
The chelating agent is 0.05 part of EDTA disodium;
the antioxidant is 0.3 part of p-hydroxyacetophenone;
the solvent is 94.02619132 parts of water.
Further, the preparation method of the hyaluronic acid toning lotion comprises the following steps:
1) weighing the phases A, B and C according to the proportion.
2) And heating, namely putting the weighed A phase into a water kettle, stirring and heating, pumping into an emulsifying kettle, keeping the temperature and stirring, and observing whether the A phase raw material is completely dissolved.
3) Cooling, cooling to 54-58 deg.C, preferably 55 deg.C, adding phase B, and stirring.
4) And cooling to below 48 deg.C, preferably below 45 deg.C, adding phase C, and stirring.
5) Discharging, and discharging when the temperature is reduced to below 40 ℃, preferably below 32 ℃.
6) And inspecting the semi-finished product.
7) And after the inspection is qualified, the product can be put into a semi-finished product warehouse.
8) And (4) filling (finished product).
Phase A raw materials: part of component 1, part of component 2, component 7, component 8 and component 15;
b phase raw materials: part of the components 2, 4, 5 and 6;
c phase raw material: part of component 1, component 3, component 9, component 10, component 11, component 12, component 13, component 14 and component 16;
wherein the content of the first and second substances,
the component 1 is water, preferably deionized water; the component 2 is butanediol and is used as a humectant; component 3 is a mixture of water, butylene glycol, and herba Portulacae (Portulaca oleracea) extract, and can be used as skin conditioner; the component 4 is a mixture consisting of methyl propylene glycol, caprylyl hydroximic acid and glyceryl caprylate and is used as a skin conditioner; component 5 is p-hydroxyacetophenone used as an antioxidant; the component 6 is 1, 2-hexanediol and is used as a humectant;
component 7 is disodium EDTA, which is used as a chelating agent; the component 8 is sodium hyaluronate used as a humectant; the component 9 is a mixture consisting of water, 1, 2-hexanediol, xanthan gum, caprylyl glycol, butylene glycol, glucose, sodium hyaluronate, Chondrus crispus (Chondrus crispus) extract, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hyaluronic acid, a sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate and potassium hyaluronate, and is used as a skin conditioner; component 10 is a tetrahydro-methyl-pyrimidine-carboxylic acid, useful as a skin conditioner; the component 11 is a mixture consisting of a secondary fission yeast fermentation product filtrate, 1, 2-hexanediol and p-hydroxyacetophenone and is used as a skin conditioner; component 12 is betaine, which acts as a humectant; component 13 is a mixture of lactobacillus/algae extract fermentation product and dipropylene glycol, used as skin conditioner; component 14 is panthenol, used as a skin conditioner; component 15 is hydrolyzed sodium hyaluronate used as humectant; component 16 is a mixture of water, centella asiatica (CENTELLAASIATICA) extract, glycerin, 1, 2-hexanediol, and p-hydroxyacetophenone, and is used as a skin conditioner.
The product of the invention is alternately rough and dry to the skin due to seasons; become tired and dull due to excessive stress; the original balance of the skin is damaged due to long-distance travel and long-time sunburn; has good cosmetic effect when aging occurs due to aging or hormone change.
In order to make the purpose and technical solution of the embodiments of the present invention clearer, the technical solution of the embodiments of the present invention will be clearly and completely described below with reference to the implementation examples of the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be made by a person skilled in the art without inventive effort based on the described embodiments of the invention, fall within the scope of protection of the invention.
Detailed description of the preferred embodiments
The technical solution of the present invention is further illustrated by the following specific examples. In the following embodiments, the raw materials are all commercially available and purchased from the relevant manufacturing enterprise or business.
Example 1
In this example 1, the raw materials were weighed in order and formulated into components 1-16: 0.24 kg of water, 0.24 kg of butylene glycol, 0.14 kg of purslane (Portulaca oleracea) extract, 0.3 kg of methylpropanediol, 0.04 kg of caprylyl hydroxamic acid, 0.003 kg of glyceryl caprylate, 0.00088 kg of water, 0.000025 kg of 1, 2-hexanediol, 0.000012 kg of xanthan gum, 0.000004 kg of caprylyl glycol, 0.0000008 kg of butylene glycol, 0.00000038 kg of glucose, 0.0185 kg of sodium hyaluronate, 0.0095 kg of Chondrus crispatus (Chondrus) extract, 0.019 kg of hydroxypropyl trimethylammonium chloride hyaluronic acid, 0.019 kg of hydrolyzed hyaluronic acid, 0.019 kg of sodium acetylate, 0.0000000009 kg of hyaluronic acid, 0.0000000009 kg of sodium hyaluronate crosspolymer, 0.0000000009 kg of hydrolyzed sodium hyaluronate, 0.0000000009 kg of potassium hyaluronate, 0.095 kg of tetrahydromethylpyrimidine carboxylic acid, 0.095 kg of fermentation product filtrate of yeast bifida, 0.0000048 kg of 1, 2-hexanediol, 0.095 kg of purslane, 0.0000038 kg of p-hydroxyacetophenone, 0.068 kg of lactobacillus/algae extract fermentation product and 0.00029 kg of dipropylene glycol, 0.00098 kg of panthenol, or 0.000835 kg of water, 0.000098 kg of centella asiatica (CENTELLAASIATICA) extract, 0.000048 kg of glycerol, 0.0000068 kg of 1, 2-hexanediol and 0.0000048 kg of p-hydroxyacetophenone.
The humectant is 3.95 kg of butanediol, 0.198 kg of 1, 2-hexanediol, 0.0098 kg of sodium hyaluronate, 0.00098 kg of betaine or 0.00098 kg of hydrolyzed sodium hyaluronate;
the chelating agent is 0.048 kg of EDTA disodium;
the antioxidant is 0.295 kg of p-hydroxyacetophenone;
the solvent was 94.01 kg of water.
The hyaluronic acid lotion of the present example was prepared by the following steps, comprising:
1) weighing the phases A, B and C according to the proportion.
2) And heating, namely putting the weighed A phase into a water kettle, stirring and heating, pumping into an emulsifying kettle, keeping the temperature and stirring, and observing whether the A phase raw material is completely dissolved.
3) Cooling, adding phase B when the temperature of the emulsifying pot is reduced to 55 ℃, and uniformly stirring.
4) And when the temperature is reduced to below 45 ℃, adding the phase C, and uniformly stirring.
5) Discharging, and discharging when the temperature is reduced to below 40 ℃.
6) And inspecting the semi-finished product.
7) And after the inspection is qualified, the product can be put into a semi-finished product warehouse.
8) And (4) filling (finished product).
Phase A raw materials: partial group kg 1, partial group kg 2, group kg 7, group kg 8, group kg 15;
b phase raw materials: part of group kilogram 2, group kilogram 4, group kilogram 5, group kilogram 6;
c phase raw material: part of group kg 1, group kg 3, group kg 9, group kg 10, group kg 11, group kg 12, group kg 13, group kg 14, group kg 16;
example 2
In this example 1, the raw materials were weighed in order and formulated into components 1-16: 0.26 kg of water, 0.26 kg of butylene glycol, 0.16 kg of purslane (Portulaca oleracea) extract, 0.4 kg of methylpropanediol, 0.06 kg of caprylyl hydroxamic acid, 0.005 kg of glyceryl caprylate, 0.00098 kg of water, 0.000035 kg of 1, 2-hexanediol, 0.000014 kg of xanthan gum, 0.000006 kg of caprylyl glycol, 0.0000012 kg of butylene glycol, 0.00000042 kg of glucose, 0.0215 kg of sodium hyaluronate, 0.0115 kg of Chondrus crispus (Chondrus crispus) extract, 0.021 kg of hydroxypropyl trimethylammonium chloride hyaluronic acid, 0.021 kg of hydrolyzed hyaluronic acid, 0.021 kg of sodium hyaluronate, 0.021 kg of acetylated hyaluronic acid, 0.0000000011 kg of hyaluronic acid, 0.0000000011 kg of sodium hyaluronate cross-linked polymer, 0.0000000011 kg of hydrolyzed sodium hyaluronate, 0.0000000011 kg of potassium hyaluronate, 0.15 kg of tetrahydromethylpyrimidine carboxylic acid, 0.15 kg of fermentation product filtrate of yeast bifida, 1, 2-hexanediol, 0.00000.052 kg of 1, 2-hexanediol, 0.0000042 kg of p-hydroxyacetophenone, a mixture of 0.072 kg of lactobacillus/algae extract fermentation product and 0.00031 kg of dipropylene glycol, 0.00102 kg of panthenol, or a mixture of 0.000840 kg of water, 0.000102 kg of centella asiatica (CENTELLAASIATICA) extract, 0.000052 kg of glycerol, 0.0000072 kg of 1, 2-hexanediol and 0.0000052 kg of p-hydroxyacetophenone.
The humectant is 4.05 kg of butanediol, 0.202 kg of 1, 2-hexanediol, 0.0102 kg of sodium hyaluronate, 0.00102 kg of betaine or 0.00102 kg of hydrolyzed sodium hyaluronate;
the chelating agent is 0.052 kg of EDTA disodium;
the antioxidant is 0.305 kg of p-hydroxyacetophenone;
the solvent was 94.03 kg of water.
The hyaluronic acid lotion of the present example was prepared by the following steps, comprising:
1) weighing the phases A, B and C according to the proportion.
2) And heating, namely putting the weighed A phase into a water kettle, stirring and heating, pumping into an emulsifying kettle, keeping the temperature and stirring, and observing whether the A phase raw material is completely dissolved.
3) Cooling, adding phase B when the temperature of the emulsifying pot is reduced to 56 ℃, and uniformly stirring.
4) And when the temperature is reduced to below 46 ℃, adding the phase C, and uniformly stirring.
5) Discharging, and discharging when the temperature is reduced to below 38 ℃.
6) And inspecting the semi-finished product.
7) And after the inspection is qualified, the product can be put into a semi-finished product warehouse.
8) And (4) filling (finished product).
Example 3
In this example 3, the raw materials were weighed in order and formulated into components 1-16: 0.2485 kg of water, 0.25 kg of butylene glycol, 0.15 kg of purslane (Portulaca oleracea) extract, 0.348 kg of methyl propylene glycol, 0.048 kg of caprylyl hydroxamic acid, 0.004 kg of glyceryl caprylate, 0.000950275 kg of water, 0.00003 kg of 1, 2-hexanediol, 0.000013 kg of xanthan gum, 0.000005 kg of caprylyl glycol, 0.000001 kg of butylene glycol, 0.0000004 kg of glucose, 0.02 kg of sodium hyaluronate, 0.01 kg of Chondrus crispatus (Chondrus) extract, 0.02 kg of hydroxypropyl trimonium chloride hyaluronic acid, 0.02 kg of hydrolyzed hyaluronic acid, 0.02 kg of sodium hyaluronate, 0.0000000000001 kg of hyaluronic acid, 0.000000001 kg of cross-linked polymer, 0.000000001 kg of hydrolyzed sodium hyaluronate, 0.00001 kg of potassium hyaluronate, 0.1 kg of tetrahydromethylpyrimidine carboxylic acid, 0.1 kg of fermentation filtrate of yeast dilracture, 0.1 kg of 1 kg of hexylene glycol, 0.05 kg of 2-00001 kg of caprylyl hydroxamic acid, 0.000004 kg of p-hydroxyacetophenone, 0.07 kg of lactobacillus/algae extract fermentation product and 0.0003 kg of dipropylene glycol, 0.001 kg of panthenol, or one or more of 0.000838 kg of water, 0.0001 kg of centella asiatica (CENTELLAASIATICA) extract, 0.00005 kg of glycerol, 0.000007 kg of 1, 2-hexanediol, and 0.000005 kg of p-hydroxyacetophenone.
The humectant is one or more of 4 kg of butanediol, 0.2 kg of 1, 2-hexanediol, 0.01 kg of sodium hyaluronate, 0.001 kg of betaine or 0.001 kg of hydrolyzed sodium hyaluronate; (ii) a
The chelating agent is 0.05 kg of EDTA disodium;
the antioxidant is 0.3 kg of p-hydroxyacetophenone;
the solvent was 94.02619132 kg of water.
The hyaluronic acid lotion of the present example was prepared by the following steps, comprising:
1) weighing the phases A, B and C according to the proportion.
2) And heating, namely putting the weighed A phase into a water kettle, stirring and heating, pumping into an emulsifying kettle, keeping the temperature and stirring, and observing whether the A phase raw material is completely dissolved.
3) Cooling, adding phase B when the temperature of the emulsifying pot is reduced to 55 ℃, and uniformly stirring.
4) And when the temperature is reduced to below 45 ℃, adding the phase C, and uniformly stirring.
5) Discharging, and discharging when the temperature is reduced to below 40 ℃.
6) And inspecting the semi-finished product.
7) And after the inspection is qualified, the product can be put into a semi-finished product warehouse.
8) And (4) filling (finished product).
Example 4
In this example 3, the raw materials were weighed in order and formulated into components 1-16: a mixture consisting of 0.22 kg of water, 0.22 kg of butylene glycol, 0.12 kg of purslane (Portulaca oleracea) extract, a mixture consisting of 0.2 kg of methylpropanediol, 0.03 kg of caprylyl hydroxamic acid, and 0.0035 kg of glyceryl caprylate, a mixture consisting of 0.00080 kg of water, 0.000022 kg of 1, 2-hexanediol, 0.000010 kg of xanthan gum, 0.000002 kg of caprylyl glycol, 0.0000006 kg of butylene glycol, 0.00000035 kg of glucose, 0.0180 kg of sodium hyaluronate, 0.0090 kg of Chondrus crispus (Chondrus) extract, 0.015 kg of hydroxypropyl trimethyl ammonium chloride hyaluronic acid, 0.015 kg of hydrolyzed hyaluronic acid, 0.018 kg of sodium hyaluronate, 0.0000000005 kg of sodium hyaluronate cross-linked polymer 0.0000000002 kg, sodium hyaluronate 0.0000000002, and 0.0000000002 kg of potassium hyaluronate, 0.092 kg of tetrahydro methyl pyrimidinecarboxylic acid, a mixture consisting of fermentation product of Schizosaccharomyces diaviscida, 0.092 kg of filtrate, 0.0000042 kg of 2 kg of hexanediol, 0.0000042 kg of 2-hexanediol, 0.092 kg of hydrolysate of sodium hyaluronate, 0.0000032 kg of p-hydroxyacetophenone constitutes a mixture consisting of 0.065 kg of lactobacillus/algae extract fermentation product and 0.00026 kg of dipropylene glycol, 0.00092 kg of panthenol, or a mixture consisting of 0.000830 kg of water, 0.000092 kg of centella asiatica (CENTELLAASIATICA) extract, 0.000042 kg of glycerol, 0.0000065 kg of 1, 2-hexanediol, 0.0000045 kg of p-hydroxyacetophenone.
The humectant is 3.90 kg of butanediol, 0.190 kg of 1, 2-hexanediol, 0.0092 kg of sodium hyaluronate, 0.00092 kg of betaine or 0.00092 kg of hydrolyzed sodium hyaluronate;
the chelating agent is 0.045 kg of EDTA disodium;
the antioxidant is 0.290 kg of p-hydroxyacetophenone;
the solvent was 92.01 kg of water.
The hyaluronic acid lotion of the present example was prepared by the following steps, comprising:
1) weighing the phases A, B and C according to the proportion.
2) And heating, namely putting the weighed A phase into a water kettle, stirring and heating, pumping into an emulsifying kettle, keeping the temperature and stirring, and observing whether the A phase raw material is completely dissolved.
3) Cooling, adding phase B when the temperature of the emulsifying pot is reduced to 55 ℃, and uniformly stirring.
4) And when the temperature is reduced to below 45 ℃, adding the phase C, and uniformly stirring.
5) Discharging, and discharging when the temperature is reduced to below 40 ℃.
6) And inspecting the semi-finished product.
7) And after the inspection is qualified, the product can be put into a semi-finished product warehouse.
8) And (4) filling (finished product).
Example 5
In this example 3, the raw materials were weighed in order and formulated into components 1-16: a mixture consisting of 0.28 kg of water, 0.28 kg of butylene glycol, 0.18 kg of purslane (Portulaca oleracea) extract, a mixture consisting of 0.5 kg of methylpropanediol, 0.08 kg of caprylyl hydroxamic acid, 0.0055 kg of glyceryl caprylate, a mixture consisting of 0.00100 kg of water, 0.000038 kg of 1, 2-hexanediol, 0.000015 kg of xanthan gum, 0.000008 kg of caprylyl glycol, 0.0000014 kg of butylene glycol, 0.00000045 kg of glucose, 0.0220 kg of sodium hyaluronate, 0.0120 kg of Chondrus crispus (Chondrus) extract, 0.023 of hydroxypropyl trimethyl ammonium chloride hyaluronic acid, 0.022 kg of hydrolyzed hyaluronic acid, 0.022 kg of sodium hyaluronate, 0.022 kg of hyaluronic acid, 0.0000000015 kg of hyaluronic acid, 0.0000000022 kg of sodium hyaluronate cross-linked polymer, 0.0000000022 kg of hydrolyzed sodium hyaluronate, 0.0000000022 kg of potassium hyaluronate, 0.18 kg of tetrahydro methyl pyrimidinecarboxylic acid, a mixture consisting of fermentation product of schizophyllan yeast, 0.16 kg of 1, 2-hexanediol, 0.062 kg of hydrolyzed hyaluronic acid, 0.8 kg of sodium hyaluronate, 0.0000045 kg of p-hydroxyacetophenone constituted a mixture of 0.075 kg of lactobacillus/algae extract fermentation product and 0.00034 kg of dipropylene glycol, 0.00105 kg of panthenol, or a mixture of 0.000848 kg of water, 0.000108 kg of centella asiatica (CENTELLAASIATICA) extract, 0.000056 kg of glycerol, 0.0000075 kg of 1, 2-hexanediol and 0.0000058 kg of p-hydroxyacetophenone.
The humectant is 4.10 kg of butanediol, 0.205 kg of 1, 2-hexanediol, 0.0105 kg of sodium hyaluronate, 0.00105 kg of betaine or 0.00108 kg of hydrolyzed sodium hyaluronate;
the chelating agent is 0.055 kilogram of EDTA disodium;
the antioxidant is 0.310 kg of p-hydroxyacetophenone;
the solvent was 96.08 kg of water.
The hyaluronic acid lotion of the present example was prepared by the following steps, comprising:
1) weighing the phases A, B and C according to the proportion.
2) And heating, namely putting the weighed A phase into a water kettle, stirring and heating, pumping into an emulsifying kettle, keeping the temperature and stirring, and observing whether the A phase raw material is completely dissolved.
3) Cooling, adding phase B when the temperature of the emulsifying pot is reduced to 55 ℃, and uniformly stirring.
4) And when the temperature is reduced to below 45 ℃, adding the phase C, and uniformly stirring.
5) Discharging, and discharging when the temperature is reduced to below 40 ℃.
6) And inspecting the semi-finished product.
7) And after the inspection is qualified, the product can be put into a semi-finished product warehouse.
8) And (4) filling (finished product).
The above description further describes a specific embodiment of the present invention with reference to specific examples, which are intended for the detailed description of the present invention and are not intended to limit the present invention. The above-mentioned embodiments are merely descriptions of the preferred embodiments of the present invention, and do not limit the technical concept and the protection scope of the present invention, and various modifications and improvements made to the technical concept by those skilled in the art without departing from the design concept of the present invention shall fall within the protection scope of the present invention.
Claims (7)
1. A hyaluronic acid lotion, characterized in that the hyaluronic acid lotion is composed of a skin conditioner, a humectant, a chelating agent, an antioxidant, and a solvent.
2. Hyaluronic acid lotion according to claim 1, characterised in that the skin conditioning agent is selected from the group consisting of a mixture consisting of water, butylene glycol, purslane (portulaca oleracea) extract, a mixture consisting of methylpropanediol, caprylic hydroxamic acid, glyceryl caprylate, a mixture consisting of water, 1, 2-hexanediol, xanthan gum, caprylyl glycol, butylene glycol, glucose, sodium hyaluronate, Chondrus crispus (Chondruscrispus) extract, hydroxypropyltrimonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hyaluronic acid, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, potassium hyaluronate, tetrahydromethylpyrimidic acid, a mixture consisting of a fermentation product filtrate of saccharomyces bifidus, 1, 2-hexanediol, p-hydroxyacetophenone, a mixture consisting of a fermentation product of lactobacillus/algae extract and dipropylene glycol, panthenol, or one or more of water, herba Centellae (CENTELLAASIATICA) extract, glycerol, 1, 2-hexanediol, and p-hydroxyacetophenone.
The humectant is one or more of butanediol, 1, 2-hexanediol, sodium hyaluronate, betaine or hydrolyzed sodium hyaluronate; (ii) a
The chelating agent is EDTA disodium;
the antioxidant is p-hydroxyacetophenone;
the solvent is water.
3. The hyaluronic acid astringent according to claim 2, wherein the hyaluronic acid astringent comprises the following raw materials in parts by weight:
the skin conditioner is selected from a mixture consisting of 0.22-0.28 part of water, 0.22-0.28 part of butanediol, 0.12-0.18 part of purslane (Portulaca oleracea) extract, a mixture consisting of 0.2-0.5 part of methyl propylene glycol, 0.03-0.08 part of caprylyl hydroximic acid and 0.0035-0.0055 part of glyceryl caprylate, a mixture consisting of 0.00080-0.00100 part of water, 1, 2-hexanediol 0.000022-0.000038 parts of xanthan gum, 0.000010-0.000015 parts of caprylyl glycol, 0.000002-0.000008 part of butylene glycol 0.0000006-567 parts of glucose, 0.00000035-0.00000045 parts of glucose, 0.0180-0.0220 parts of sodium hyaluronate, 0.0090-0.0120 part of Chondrus crispus (Chondrus) extract, 0.015-0.023, 0.015-0.022, 0.0220.022-0.493 parts of hyaluronic acid cross-linked polymer, 0.0023-493-0.4 parts of sodium hyaluronate, 0.0000000002-0.0000000022 parts of hydrolyzed sodium hyaluronate, 0.0000000002-0.0000000022 parts of potassium hyaluronate, 0.092-0.18 part of tetrahydro methyl pyrimidine carboxylic acid, 0.092-0.16 part of a yeast fermentation product filtrate, 0.0000042-0.0000062 part of 1, 2-hexanediol and 0.0000032-0.0000045 parts of p-hydroxyacetophenone, 0.065-0.075 part of a lactobacillus/algae extract fermentation product and 0.00026-0.00034 part of dipropylene glycol, 0.00092-0.00105 parts of panthenol, or one or more of water 0.000830-0.000848 parts, 0.000092-0.000108 parts of centella asiatica (CENTELLAASIATICA) extract, 0.000042-0.000056 parts of glycerol, 0.0000065-0.0000075 parts of 1, 2-hexanediol and 0.0000045-0.0000058 parts of p-hydroxyacetophenone;
the humectant is one or more of 3.90-4.10 parts of butanediol, 0.190-0.205 part of 1, 2-hexanediol, 0.0092-0.0105 part of sodium hyaluronate, 0.00092-0.00105 parts of betaine or 0.00092-0.00108 part of hydrolyzed sodium hyaluronate;
the chelating agent is 0.045-0.055 part of EDTA disodium;
the antioxidant is 0.290-0.310 part of p-hydroxyacetophenone;
the solvent is 92.01-96.08 parts of water.
4. The hyaluronic acid lotion according to claim 3, wherein the skin conditioner is selected from the group consisting of a mixture consisting of 0.24-0.26 parts of water, 0.24-0.26 parts of butylene glycol, 0.14-0.16 parts of purslane (Portulaca oleracea) extract, a mixture consisting of 0.3-0.4 parts of methyl propylene glycol, 0.04-0.06 parts of caprylyl hydroximic acid, 0.003-0.005 parts of glyceryl caprylate, a mixture consisting of 0.00088-0.00098 parts of water, 0.000025-0.000035 parts of 1, 2-hexanediol, 0.000012-0.000014 parts of xanthan gum, 0.000004-0.000006 parts of caprylyl glycol, 0.0000008-0.0000012 parts of butylene glycol, 0.00000038-0.00000042 parts of glucose, 0.0185-0.0215 parts of sodium hyaluronate, 0.0095-0.0115 parts of Chondrus crispus (Chondrus) extract, 0.019-0.021 part of hydrolyzed hyaluronic acid, 0.021-0.019 parts of hyaluronic acid, 0.021-0.021 part of hyaluronic acid, 0.021 part of hydrolyzed hyaluronic acid, 0.021 ammonium chloride, 0.5 parts of hyaluronic acid, 0.0000000009-0.0000000011 parts of hyaluronic acid, 0.0000000009-0.0000000011 parts of sodium hyaluronate cross-linked polymer, 0.0000000009-0.0000000011 parts of hydrolyzed sodium hyaluronate and 0.0000000009-0.0000000011 parts of potassium hyaluronate, 0.095-0.15 part of tetrahydro methyl pyrimidine carboxylic acid, a mixture consisting of 0.095-0.15 part of yeast fermentation product filtrate, 0.0000048-0.0000052 parts of 1, 2-hexanediol and 0.0000038-0.0000042 parts of p-hydroxyacetophenone, a mixture consisting of 0.068-0.072 part of lactobacillus/algae extract fermentation product and 0.00029-0.00031 part of dipropylene glycol, 0.00098-0.00102 parts of panthenol, or one or more of a mixture consisting of 0.000835-0.000840 parts of water, 0.000098-0.000102 parts of asiatic pennywort (CENTELLAASIATICA) extract, 0.000048-0.000052 parts of glycerol, 1, 2-hexanediol 0.0000068-0.0000072 parts of p-hydroxyacetophenone and 0.0000048-0.0000 parts of p-hydroxyacetophenone.
The humectant is one or more of 3.95-4.05 parts of butanediol, 0.198-0.202 part of 1, 2-hexanediol, 0.0098-0.0102 parts of sodium hyaluronate, 0.00098-0.00102 parts of betaine or 0.00098-0.00102 parts of hydrolyzed sodium hyaluronate;
the chelating agent is 0.048-0.052 parts of EDTA disodium;
the antioxidant is 0.295-0.305 part of p-hydroxyacetophenone;
the solvent is 94.01-94.03 parts of water.
5. The hyaluronic acid lotion according to claim 4, characterized in that the skin conditioner is selected from the group consisting of a mixture consisting of 0.2485 parts of water, 0.25 parts of butylene glycol, 0.15 parts of extract of purslane (Portulaca oleracea), a mixture consisting of 0.348 parts of methyl propylene glycol, 0.048 parts of caprylyl hydroxamic acid, 0.004 parts of glyceryl caprylate, a mixture consisting of 0.000950275 parts of water, 0.00003 parts of 1, 2-hexanediol, 0.000013 parts of xanthan gum, 0.000005 parts of caprylyl glycol, 0.000001 parts of butylene glycol, 0.0000004 parts of glucose, 0.02 parts of sodium hyaluronate, 0.01 parts of Chonus crispatus (Chonus Crispus) extract, 0.02 parts of hydroxypropyl trimonium chloride hyaluronic acid, 0.02 parts of hydrolyzed hyaluronic acid, 0.02 parts of sodium acetylated hyaluronate, 0.000000001 parts of hyaluronic acid, 0.000000001 parts of sodium hyaluronate cross-linked polymer, 0.000000001 parts of hydrolyzed sodium hyaluronate, 0.000000001 parts of potassium hyaluronate, 0.00001 parts of a mixture of tetrahydropyrimidine yeast filtrate, and a yeast hydrolysate of yeast, 0.000005 part of 1, 2-hexanediol, 0.000004 part of p-hydroxyacetophenone, 0.07 part of lactobacillus/algae extract fermentation product and 0.0003 part of dipropylene glycol, 0.001 part of panthenol, or one or more of water 0.000838 parts, 0.0001 part of centella asiatica (CENTELLAASIATICA) extract, 0.00005 part of glycerol, 0.000007 part of 1, 2-hexanediol and 0.000005 part of p-hydroxyacetophenone;
the humectant is one or more of 4 parts of butanediol, 0.2 part of 1, 2-hexanediol, 0.01 part of sodium hyaluronate, 0.001 part of betaine or 0.001 part of hydrolyzed sodium hyaluronate; (ii) a
The chelating agent is 0.05 part of EDTA disodium;
the antioxidant is 0.3 part of p-hydroxyacetophenone;
the solvent is 94.02619132 parts of water.
6. A method for preparing hyaluronic acid lotion, characterized in that the preparation method comprises:
1) weighing the phases A, B and C according to the proportion;
2) heating, putting the weighed phase A into a water kettle, stirring and heating, pumping into an emulsifying kettle, keeping the temperature and stirring, and observing whether the phase A raw material is completely dissolved;
3) cooling, cooling to 54-58 deg.C, adding phase B, and stirring;
4) cooling to below 48 ℃, adding the phase C, and uniformly stirring;
5) discharging, cooling to below 40 ℃, and discharging;
6) checking the semi-finished product;
7) after the inspection is qualified, the semi-finished products can be put into a semi-finished product warehouse;
8) filling (finished product);
phase A raw materials: part of component 1, part of component 2, component 7, component 8 and component 15;
b phase raw materials: part of the components 2, 4, 5 and 6;
c phase raw material: part of component 1, component 3, component 9, component 10, component 11, component 12, component 13, component 14 and component 16;
wherein the content of the first and second substances,
the component 1 is water, preferably deionized water; the component 2 is butanediol and is used as a humectant; component 3 is a mixture of water, butylene glycol, and herba Portulacae (Portulaca oleracea) extract, and can be used as skin conditioner; the component 4 is a mixture consisting of methyl propylene glycol, caprylyl hydroximic acid and glyceryl caprylate and is used as a skin conditioner; component 5 is p-hydroxyacetophenone used as an antioxidant; the component 6 is 1, 2-hexanediol and is used as a humectant;
component 7 is disodium EDTA, which is used as a chelating agent; the component 8 is sodium hyaluronate used as a humectant; the component 9 is a mixture consisting of water, 1, 2-hexanediol, xanthan gum, caprylyl glycol, butylene glycol, glucose, sodium hyaluronate, Chondrus crispus (Chondrus crispus) extract, hydroxypropyl trimethyl ammonium chloride hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hyaluronic acid, a sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate and potassium hyaluronate, and is used as a skin conditioner; component 10 is a tetrahydro-methyl-pyrimidine-carboxylic acid, useful as a skin conditioner; the component 11 is a mixture consisting of a secondary fission yeast fermentation product filtrate, 1, 2-hexanediol and p-hydroxyacetophenone and is used as a skin conditioner; component 12 is betaine, which acts as a humectant; component 13 is a mixture of lactobacillus/algae extract fermentation product and dipropylene glycol, used as skin conditioner; component 14 is panthenol, used as a skin conditioner; component 15 is hydrolyzed sodium hyaluronate used as humectant; component 16 is a mixture of water, centella asiatica (CENTELLAASIATICA) extract, glycerin, 1, 2-hexanediol, and p-hydroxyacetophenone, and is used as a skin conditioner.
7. The method for preparing hyaluronic acid astringent according to claim 6, characterized in that the preparation method comprises:
1) weighing the phases A, B and C according to the proportion;
2) heating, putting the weighed phase A into a water kettle, stirring and heating, pumping into an emulsifying kettle, keeping the temperature and stirring, and observing whether the phase A raw material is completely dissolved;
3) cooling, cooling to 55 deg.C, adding phase B, and stirring;
4) cooling to below 45 ℃, adding the phase C, and uniformly stirring;
5) discharging, cooling to below 32 ℃, and discharging;
6) checking the semi-finished product;
7) after the inspection is qualified, the semi-finished products can be put into a semi-finished product warehouse;
8) and (4) filling (finished product).
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| CN106109296A (en) * | 2016-06-30 | 2016-11-16 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
| CN112315849A (en) * | 2020-12-10 | 2021-02-05 | 广州诗妃生物科技有限公司 | Moisturizing composition containing 8 kinds of hyaluronic acid and preparation method thereof |
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| CN106109296A (en) * | 2016-06-30 | 2016-11-16 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
| CN112315849A (en) * | 2020-12-10 | 2021-02-05 | 广州诗妃生物科技有限公司 | Moisturizing composition containing 8 kinds of hyaluronic acid and preparation method thereof |
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