CN112915050A - Polypeptide anti-aging repair essence and preparation method thereof - Google Patents
Polypeptide anti-aging repair essence and preparation method thereof Download PDFInfo
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- CN112915050A CN112915050A CN202110287608.7A CN202110287608A CN112915050A CN 112915050 A CN112915050 A CN 112915050A CN 202110287608 A CN202110287608 A CN 202110287608A CN 112915050 A CN112915050 A CN 112915050A
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- tremella fuciformis
- ergothioneine
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- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 38
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 38
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 38
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 38
- 230000008439 repair process Effects 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 241000121220 Tricholoma matsutake Species 0.000 claims abstract description 54
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 46
- 241000216654 Armillaria Species 0.000 claims abstract description 42
- 239000000203 mixture Substances 0.000 claims abstract description 36
- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 claims abstract description 35
- 229940093497 ergothioneine Drugs 0.000 claims abstract description 35
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims abstract description 35
- WSGCRSMLXFHGRM-DEVHWETNSA-N (2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s,3r)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O WSGCRSMLXFHGRM-DEVHWETNSA-N 0.000 claims abstract description 23
- QGGBBQJHVCVVKM-XOBYPWAZSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amin Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(N)=O QGGBBQJHVCVVKM-XOBYPWAZSA-N 0.000 claims abstract description 23
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 23
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 23
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims abstract description 23
- 108010087806 Carnosine Proteins 0.000 claims abstract description 23
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 23
- 229940078033 acetyl octapeptide-3 Drugs 0.000 claims abstract description 23
- 229960000458 allantoin Drugs 0.000 claims abstract description 23
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims abstract description 23
- 229940044199 carnosine Drugs 0.000 claims abstract description 23
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000006166 lysate Substances 0.000 claims abstract description 23
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 23
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 23
- 238000000855 fermentation Methods 0.000 claims abstract description 21
- 230000004151 fermentation Effects 0.000 claims abstract description 21
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002738 chelating agent Substances 0.000 claims abstract description 18
- 239000003906 humectant Substances 0.000 claims abstract description 18
- 239000002904 solvent Substances 0.000 claims abstract description 18
- 241000235346 Schizosaccharomyces Species 0.000 claims abstract description 17
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 17
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 17
- 239000002562 thickening agent Substances 0.000 claims abstract description 17
- 241000222518 Agaricus Species 0.000 claims abstract description 16
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical group CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 44
- 241000908178 Tremella fuciformis Species 0.000 claims description 44
- 238000003756 stirring Methods 0.000 claims description 44
- 238000001816 cooling Methods 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 22
- 229920006037 cross link polymer Polymers 0.000 claims description 22
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 21
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 19
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 17
- 150000002148 esters Chemical class 0.000 claims description 17
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 17
- 229920001567 vinyl ester resin Polymers 0.000 claims description 17
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 15
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- 241000235070 Saccharomyces Species 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 230000032683 aging Effects 0.000 abstract description 4
- 230000008859 change Effects 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 206010042496 Sunburn Diseases 0.000 abstract description 2
- 239000005556 hormone Substances 0.000 abstract description 2
- 229940088597 hormone Drugs 0.000 abstract description 2
- 230000035882 stress Effects 0.000 abstract description 2
- 241001506047 Tremella Species 0.000 abstract 1
- 239000000686 essence Substances 0.000 description 56
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 18
- 235000006708 antioxidants Nutrition 0.000 description 11
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 9
- 229930003268 Vitamin C Natural products 0.000 description 9
- 235000019154 vitamin C Nutrition 0.000 description 9
- 239000011718 vitamin C Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000003750 conditioning effect Effects 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- GADGVXXJJXQRSA-UHFFFAOYSA-N ethenyl 8-methylnonanoate Chemical compound CC(C)CCCCCCC(=O)OC=C GADGVXXJJXQRSA-UHFFFAOYSA-N 0.000 description 5
- 206010003399 Arthropod bite Diseases 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
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- 241000222481 Schizophyllum commune Species 0.000 description 2
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- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 206010004950 Birth mark Diseases 0.000 description 1
- 235000003880 Calendula Nutrition 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 241000195888 Physcomitrella Species 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a polypeptide anti-aging repair essence and a preparation method thereof, wherein the polypeptide anti-aging repair essence consists of a skin conditioner, a humectant, a pH regulator, a chelating agent, a thickening agent, an antioxidant and a solvent, wherein the skin conditioner is selected from one or more of allantoin, hydrolyzed sodium hyaluronate, a Tremella (TREEMALIFICIFORMIS) fruiting body extract, 1, 2-hexanediol, bioglycan-1, a schizosaccharomyces cerevisiae fermentation product lysate, a mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4. The product of the invention is alternately rough and dry to the skin due to seasons; become tired and dull due to excessive stress; the original balance of the skin is damaged due to long-distance travel and long-time sunburn; has good cosmetic effect when aging occurs due to aging or hormone change.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a polypeptide anti-aging repair essence and a preparation method thereof.
Background
The essence is divided into water aqua and oil solution, and the extracted high-nutrient substances are concentrated. The plant essence is extracted from various wild or artificially planted plants, such as mulberry leaf essence, rose essence, calendula essence and the like, is most popular with aloe, is suitable for various skin types due to small irritation, and has the main effects of moistening, balancing moisture and grease secretion, eliminating redness and swelling and relieving inflammation. The essence is a colloidal nutrient solution which is developed according to the skin activity principle, has a natural plant formula, and can slow down fine wrinkles of eyes, delay the skin aging speed and enable the skin to reappear vitality and luster; plant essences are used for extracting effective bioactive polypeptide sequences from natural plants (Physcomitrella), and various technologies such as combinatorial chemistry, active polypeptide optimization and the like are combined. Its birth mark is the conversion of anti-wrinkle cosmetics from traditional active matter to biological active matter.
In the prior art, the patent application for invention with publication number CN109010120A invention name hydrous vitamin C double-layer essence, a preparation method and a use method discloses a non-discoloring hydrous vitamin C double-layer essence, a preparation method and a use method, wherein the double-layer essence has a double-layer structure comprising: the alcohol component, the water and the vitamin C are mutually dissolved to form an essence main body layer, the oil component is attached to the upper surface of the essence main body layer to form an essence covering layer, and therefore the essence main body layer and the essence covering layer jointly form the double-layer essence. The solubility of the vitamin C is improved by the alcohol component, the content of water is reduced by adding the alcohol component, and the problem of color change of the vitamin C is effectively reduced; meanwhile, the vitamin C is dissolved in the mixed solution of the alcohol component and the water, so that the viscosity of the essence body formed by the alcohol component, the water and the vitamin C is greatly reduced, and the problem of viscosity of the existing anhydrous formula VC essence is solved. In addition, the double-layer essence is adopted, the lower layer is an essence main body layer, and the upper layer is an essence covering layer formed by oil and fat components, so that the contact between the vitamin C and the air is reduced, and the color change of the vitamin C is avoided.
The publication number CN108272744A discloses a capsule essence and a method for manufacturing the capsule essence, and discloses an essence and a capsule, wherein the capsule comprises a liquid core consisting of the essence and a gel shell completely encapsulating the liquid core; the invention also discloses a method for preparing the capsule essence, which adopts an injector to inject the essence into a dropper, so that the essence forms liquid drops at the outlet of the dropper, and the liquid drops drop into a container filled with a gelling solution to generate a gelling reaction, thereby forming a gel shell which completely encapsulates the liquid core.
The publication No. CN103705420A invention discloses a mosquito bite detumescence essence for children and a preparation method thereof, the essence disclosed comprises a component A, a component B and a component C, wherein the component A comprises 25-30% of polyhydric alcohol, 1.5-3.5% of solubilizer, 0.2-0.4% of freshener and 0.1-0.3% of tea tree oil according to the total weight percentage of the essence; the component B comprises 65-70% of deionized water, 0.5-2% of humectant and 0.05-0.1% of chelating agent according to the total weight percentage of the essence; the component C comprises 0.15-0.25% of rutin extract, 1-3% of cortex moutan extract and 0.1-0.3% of pyrrolidone carboxylic acid sodium salt according to the total weight percentage of the essence. The essence solution has effects of refreshing, relieving pain and itching of red and swollen part after mosquito bite, rapidly relieving swelling and itching, and treating mosquito bite.
The existing makeup industry designs skin care products with different types and different effects aiming at people with different skin states, and it is very necessary to design a mild anti-aging repair essence liquid suitable for most people. Therefore, it is an objective need to provide a fixed formula anti-aging repair essence, which is convenient for consumers to use and provides ideal cosmetic effects.
Disclosure of Invention
In order to overcome the defects of the existing skin care products, the invention aims to provide a polypeptide anti-aging repair essence; the invention also aims to provide a preparation method of the polypeptide anti-aging repair essence.
The polypeptide anti-aging repair essence is realized by the following technical scheme.
The polypeptide anti-aging repair essence disclosed by the invention comprises a skin conditioner, a humectant, a chelating agent, a thickening agent, a pH regulator, an antioxidant and a solvent.
Wherein the skin conditioning agent is selected from one or more of allantoin, hydrolyzed sodium hyaluronate, extract of fruiting body of Tremella FUCIFORMIS (Tremella FUCIFORMIS), 1, 2-hexanediol, bioglycan-1, lysate of fermentation product of Schizosaccharomyces cerevisiae, mixture of ergothioneine, extract of Armillaria matsutake (ARMILLARIA MATSUTAKE), 1, 2-pentanediol and ethylhexylglycerin, carnosine, acetyl octapeptide-3, palmitoyl pentapeptide-4;
the humectant is glyceryl polyether-26;
the thickening agent is an acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer;
the chelating agent is EDTA disodium;
the pH regulator is triethanolamine;
the antioxidant is p-hydroxyacetophenone;
the solvent is water.
In the technical scheme of the invention, the mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin is a mixture consisting of 0.01-0.03 part of ergothioneine, 90-120 parts of agaricus (ARMILLARIA MATSUTAKE) extract, 3.0-5.0 parts of 1, 2-pentanediol and 0.07-0.1 part of ethylhexylglycerin in parts by weight; the solvent water is preferably deionized water.
In the technical scheme of the invention, the skin conditioning agent, the humectant, the chelating agent, the thickener, the pH regulator, the antioxidant and the solvent can be obtained from the market except for special instructions.
Further, in the technical scheme of the invention, the polypeptide anti-aging repair essence comprises the following raw materials in parts by weight:
wherein the skin conditioning agent is selected from one or more of allantoin 0.16-0.24 parts, hydrolyzed sodium hyaluronate 0.08-0.12 parts, Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.08-0.12 parts, 1, 2-hexanediol 0.74-0.96 parts, biogel-1 0.4-0.6 parts, Schizophyllum commune fermentation product lysate 0.4-0.6 parts, mixture composed of ergothioneine, matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin 0.4-0.6 parts, carnosine 0.16-0.24 parts, acetyl octapeptide-3 0.4-0.6 parts, and palmitoyl pentapeptide-4 0.8-1.2 parts;
4-6 parts of humectant glycerin polyether-26;
0.32-0.48 part of thickener acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer;
the chelating agent is 0.024-0.036 parts of EDTA disodium;
the pH regulator is 0.32-0.48 part of triethanolamine;
the antioxidant is 0.4-0.6 part of p-hydroxyacetophenone;
the solvent is 72-108 parts of water.
Preferably, in the technical scheme of the invention, the polypeptide anti-aging repair essence comprises the following raw materials in parts by weight:
wherein the skin conditioning agent is selected from one or more of allantoin 0.18-0.22 parts, hydrolyzed sodium hyaluronate 0.09-0.11 parts, Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.09-0.11 parts, 1, 2-hexanediol 0.72-0.88 parts, biogel-1 0.45-0.55 parts, Schizophyllum commune fermentation product lysate 0.45-0.55 parts, mixture composed of ergothioneine, Armillaria matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol 0.45-0.55 parts, carnosine 0.18-0.22 parts, acetyl octapeptide-3 0.45-0.55 parts, and palmitoyl pentapeptide-4 0.9-1.1 parts;
4.5-5.5 parts of humectant glycerin polyether-26;
0.36-0.44 part of thickener acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer;
the chelating agent is 0.027-0.033 parts of disodium EDTA;
the pH regulator is 0.36-0.44 parts of triethanolamine;
the antioxidant is 0.45-0.55 part of p-hydroxyacetophenone;
the solvent is 82-99 parts of water.
Most preferably, the polypeptide anti-aging repair essence comprises the following components in parts by weight:
wherein the skin conditioning agent is selected from one or more of the group consisting of allantoin 0.2 parts, hydrolyzed sodium hyaluronate 0.1 parts, TREMELLA FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.1 parts, 1, 2-hexanediol 0.8 parts, bioglycan-1 0.5 parts, yeast bifida fermentation product lysate 0.5 parts, mixture consisting of ergothioneine, matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin 0.5 parts, carnosine 0.2 parts, acetyl octapeptide-3 0.5 parts, and palmitoyl pentapeptide-4 1 part;
the humectant glycerin polyether-26 is 5 parts;
0.4 part of thickener acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer;
the chelating agent is 0.03 part of EDTA disodium;
the pH regulator is 0.4 part of triethanolamine;
the antioxidant is 0.5 part of p-hydroxyacetophenone;
the solvent is 89.27 parts of water.
Further, the technical scheme of the invention also comprises a preparation method of the polypeptide anti-aging repair essence, and the preparation method comprises the following steps:
step one, stirring and heating the phase A to 86-94 ℃, preferably 88-91 ℃, most preferably 90 ℃, preserving heat and sterilizing for 25-35 minutes, preferably 28-32 minutes, most preferably 30 minutes, and then cooling at constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin.
And step two, cooling the phase A in the step one to 62-67 ℃ at a constant speed, preferably 64-66 ℃, most preferably 65 ℃, adding the preheated and dissolved phase A1, and stirring uniformly. The A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
and step three, adding the A2 phase into the product obtained in the step two, uniformly stirring, and continuously cooling. The A2 phase is triethanolamine;
step four, when the product of the step three is cooled to 44-54 ℃, preferably 46-52 ℃, and most preferably 50 ℃, adding the dispersed phase B, and stirring and dissolving uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
step five, step four products are cooled to 35-43 ℃, preferably 37-40 ℃, most preferably 38 ℃, and phase C is added in sequence, wherein the phase C comprises bioglycan-1, yeast fermentation lysate of schizosaccharomyces, mixture of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4.
And step six, qualified self-inspection, filtering and discharging, standing for 24 hours and reporting inspection.
The product of the invention is alternately rough and dry to the skin due to seasons; become tired and dull due to excessive stress; the original balance of the skin is damaged due to long-distance travel and long-time sunburn; especially, it has good skin caring effect when aging occurs due to aging or hormone change.
In order to make the purpose and technical solution of the embodiments of the present invention clearer, the technical solution of the embodiments of the present invention will be clearly and completely described below with reference to the implementation examples of the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be made by a person skilled in the art without inventive effort based on the described embodiments of the invention, fall within the scope of protection of the invention.
Detailed description of the preferred embodiments
The technical solution of the present invention is further illustrated by the following specific examples. In the following embodiments, unless otherwise specified, the raw materials are commercially available and purchased from the relevant manufacturing facility or business.
Example 1
In this example 1, the following raw materials were weighed in order: skin conditioner allantoin 0.16 g, hydrolyzed sodium hyaluronate 0.08 g, Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.08 g, 1, 2-hexanediol 0.74 g, bioglycan gum-1 0.4 g, schizosaccharomyces cerevisiae fermentation product lysate 0.4 g, mixture consisting of ergothioneine, matsutake mushroom (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin 0.4 g, carnosine 0.16 g, acetyl octapeptide-3 0.4 g, palmitoyl pentapeptide-4 0.8 g; the humectant is 4 g of glyceryl polyether-26; thickener acrylate/vinyl isodecanoate crosspolymer 0.32 g; chelating agent EDTA disodium 0.024 g; the pH regulator is triethanolamine of 0.32 g; antioxidant p-hydroxyacetophenone 0.4 g; 72 g of solvent water.
In this example, the mixture consisting of ergothioneine, matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin was a mixture consisting of 0.01 g of ergothioneine, 90 g of matsutake (ARMILLARIA MATSUTAKE) extract, 3.0 g of 1, 2-pentanediol and 0.07 g of ethylhexylglycerin.
The polypeptide anti-aging repair essence of the embodiment is prepared by the following steps:
step one, stirring phase A, heating to 90 ℃, preserving heat, sterilizing for 30 minutes, and then cooling at a constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin.
And step two, cooling the phase A in the step one to 65 ℃, adding the preheated and dissolved phase A1, and stirring uniformly. The A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
and step three, adding the A2 phase into the product obtained in the step two, uniformly stirring, and continuously cooling. The A2 phase is triethanolamine;
step four, when the product of the step three is cooled to 50 ℃, adding the dispersed phase B, and stirring and dissolving uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
cooling the products of step five and step four to the most preferable temperature of 38 ℃, and adding C phase in sequence, wherein the C phase added in sequence comprises biogum-1, schizosaccharomyces cerevisiae fermentation product lysate, mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4; and uniformly stirring to obtain the polypeptide anti-aging repair essence liquid.
Example 2
In this example 2, the following raw materials were weighed in sequence: allantoin 0.24 g, hydrolyzed sodium hyaluronate 0.12 g, Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.12 g, 1, 2-hexanediol 0.96 g, bioglycan-1 0.6 g, Dischizosaccharomyces cerevisiae fermentation product lysate 0.6 g, mixture consisting of ergothioneine, Armillaria matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol 0.6 g, carnosine 0.24 g, acetyl octapeptide-3 0.6 g, palmitoyl pentapeptide-4 1.2 g; 6 g of humectant glycerin polyether-26; thickener acrylate/vinyl isodecanoate crosspolymer 0.48 g; the chelating agent is EDTA disodium 0.036 g; the pH regulator is 0.48 g of triethanolamine; the antioxidant is p-hydroxyacetophenone 0.6; 108 grams.
In this example, the mixture consisting of ergothioneine, matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin was a mixture consisting of 0.03 g of ergothioneine, 120 g of matsutake (ARMILLARIA MATSUTAKE) extract, 5.0 g of 1, 2-pentanediol and 0.1 g of ethylhexylglycerin.
The preparation method of the polypeptide anti-aging repair essence comprises the following steps:
step one, stirring phase A, heating to 90 ℃, preserving heat, sterilizing for 30 minutes, and then cooling at a constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin.
And step two, cooling the phase A in the step one to 64 ℃ at a constant speed, adding the preheated and dissolved phase A1, and stirring uniformly. The A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
and step three, adding the A2 phase into the product obtained in the step two, uniformly stirring, and continuously cooling. The A2 phase is triethanolamine;
step four, when the product of the step three is cooled to 46 ℃, adding the dispersed phase B, and stirring and dissolving uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
cooling the product of step five and step four to 37, and adding a C phase, wherein the C phase comprises bioglycan-1, zymolite lysate of schizosaccharomyces cerevisiae, a mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4; and stirring uniformly to obtain the polypeptide anti-aging repair essence.
Example 3
In this example 3, the following raw materials were weighed in sequence: skin conditioner allantoin 0.18 g, hydrolyzed sodium hyaluronate 0.09 g, Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.09 g, 1, 2-hexanediol 0.72 g, bioglycan gum-1 0.45 g, schizosaccharomyces cerevisiae fermentation product lysate 0.45 g, mixture composed of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol 0.45 g, carnosine 0.18 g, acetyl octapeptide-3 0.45 g, palmitoyl pentapeptide-4 0.9 g; humectant glycerin polyether-26 is 4.5 g; thickener acrylate/vinyl isodecanoate crosspolymer 0.36 g; the chelating agent is 0.027 g of EDTA disodium; the pH regulator is 0.36 g of triethanolamine; the antioxidant is 0.45 g of p-hydroxyacetophenone; the solvent was 82 g of water.
In this example, the mixture consisting of ergothioneine, matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol, and ethylhexylglycerin was a mixture consisting of 0.03 g of ergothioneine, 100 g of matsutake (ARMILLARIA MATSUTAKE) extract, 5.0 g of 1, 2-pentanediol, and 0.1 g of ethylhexylglycerin.
The preparation method of the polypeptide anti-aging repair essence comprises the following steps:
step one, stirring phase A, heating to 91 ℃, preserving heat, sterilizing for 32 minutes, and then cooling at a constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin.
And step two, cooling the phase A in the step one to 66 ℃ at a constant speed, adding the preheated and dissolved phase A1, and stirring uniformly. The A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
and step three, adding the A2 phase into the product obtained in the step two, uniformly stirring, and continuously cooling. The A2 phase is triethanolamine;
step four, when the product of the step three is cooled to 52 ℃, adding the dispersed phase B, and stirring and dissolving uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
step five, step four products are cooled to 40 ℃, and phase C is added, wherein the phase C comprises bioglycan-1, schizosaccharomyces cerevisiae fermentation product lysate, mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4; and stirring uniformly to obtain the polypeptide anti-aging repair essence.
Example 4
In this example 4, the following raw materials were weighed: the skin conditioning agent is selected from allantoin 0.22 g, hydrolyzed sodium hyaluronate 0.11 g, Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.11 g, 1, 2-hexanediol 0.88 g, bioglycan gum-1 0.55 g, yeast lysate of Schizosaccharomyces cerevisiae 0.55 g, mixture composed of ergothioneine, Armillaria matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol 0.55 g, carnosine 0.22 g, acetyl octapeptide-3 0.55 g, palmitoyl pentapeptide-4 1.1 g; 5.5 g of humectant glycerin polyether-26; thickener acrylate/vinyl isodecanoate crosspolymer 0.44 g; the chelating agent is 0.033 g of EDTA disodium; the pH regulator is 0.44 g of triethanolamine; the antioxidant is 0.55 g of p-hydroxyacetophenone; 99 g of solvent water.
In this example, the mixture of ergothioneine, Armillaria matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerol was prepared as described in example 3.
The preparation method of the polypeptide anti-aging repair essence comprises the following steps:
step one, stirring phase A, heating to 86 ℃, preserving heat, sterilizing for 25 minutes, and then cooling at a constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin.
And step two, cooling the phase A in the step one to 62 ℃ at a constant speed, adding the preheated and dissolved phase A1, and stirring uniformly. The A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
and step three, adding the A2 phase into the product obtained in the step two, uniformly stirring, and continuously cooling. The A2 phase is triethanolamine;
step four, when the product of the step three is cooled to 44 ℃, adding the dispersed phase B, and stirring and dissolving uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
step five, step four products are cooled to 35 ℃, and C phase is added, wherein the C phase comprises bioglycan-1, schizosaccharomyces cerevisiae fermentation product lysate, mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4; and stirring uniformly to obtain the polypeptide anti-aging repair essence.
Example 5
In this example 5, the raw materials were weighed: skin conditioner allantoin 0.2 g, hydrolyzed sodium hyaluronate 0.1 g, Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.1 g, 1, 2-hexanediol 0.8 g, bioglycan gum-1 0.5 g, schizosaccharomyces cerevisiae fermentation product lysate 0.5 g, mixture composed of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol 0.5 g, carnosine 0.2 g, acetyl octapeptide-3 0.5 g, palmitoyl pentapeptide-4 1 g; 5 g of humectant glycerin polyether-26; thickener acrylate/vinyl isodecanoate crosspolymer 0.4 g; the chelating agent is EDTA disodium 0.03 g; the pH regulator is triethanolamine of 0.4 g; the antioxidant is p-hydroxyacetophenone 0.5; the solvent was 89.27 grams of water.
In this example, the mixture of ergothioneine, Armillaria matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerol was prepared as described in example 3.
The preparation method of the polypeptide anti-aging repair essence comprises the following steps:
step one, stirring phase A, heating to 90 ℃, preserving heat, sterilizing for 30 minutes, and then cooling at a constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin.
And step two, cooling the phase A in the step one to 65 ℃ at a constant speed, adding the preheated and dissolved phase A1, and stirring uniformly. The A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
and step three, adding the A2 phase into the product obtained in the step two, uniformly stirring, and continuously cooling. The A2 phase is triethanolamine;
step four, when the product of the step three is cooled to 50 ℃, adding the dispersed phase B, and stirring and dissolving uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
step five, step four products are cooled to 38 ℃, and phase C is added, including biogel-1, schizosaccharomyces cerevisiae fermentation product lysate, mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4; and stirring uniformly to obtain the polypeptide anti-aging repair essence.
The above description further describes a specific embodiment of the present invention with reference to specific examples, which are intended for the detailed description of the present invention and are not intended to limit the present invention. The above-mentioned embodiments are merely descriptions of the preferred embodiments of the present invention, and do not limit the technical concept and the protection scope of the present invention, and various modifications and improvements made to the technical concept by those skilled in the art without departing from the design concept of the present invention shall fall within the protection scope of the present invention.
Claims (9)
1. The polypeptide anti-aging repair essence is characterized by comprising a skin conditioner, a humectant, a pH regulator, a chelating agent, a thickening agent, an antioxidant and a solvent.
2. The polypeptide anti-aging serum according to claim 1, wherein the skin conditioner is selected from one or more of the group consisting of allantoin, hydrolyzed sodium hyaluronate, extract of fruit body of Tremella FUCIFORMIS (Tremella FUCIFORMIS), 1, 2-hexanediol, bioglycan-1, lysate of Saccharomyces bifidus fermentation product, ergothioneine, extract of Armillaria matsutake (ARMILLARIA MATSUTAKE), mixture of 1, 2-pentanediol and ethylhexylglycerin, carnosine, acetyl octapeptide-3, palmitoyl pentapeptide-4;
the humectant is glyceryl polyether-26;
the thickening agent is an acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer;
the chelating agent is EDTA disodium;
the pH regulator is triethanolamine;
the antioxidant is p-hydroxyacetophenone;
the solvent is water.
3. The polypeptide anti-aging essence according to claim 2, wherein the mixture consisting of ergothioneine, matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin is a mixture consisting of, in parts by weight, 0.01-0.03 parts of ergothioneine, 90-120 parts of matsutake (ARMILLARIA MATSUTAKE) extract, 3.0-5.0 parts of 1, 2-pentanediol and 0.07-0.1 parts of ethylhexylglycerin.
4. The polypeptide anti-aging repair essence according to claim 2 or 3, which is characterized by comprising the following raw materials in parts by weight:
the skin conditioner is selected from one or more of the group consisting of 0.16-0.24 parts of allantoin, 0.08-0.12 parts of hydrolyzed sodium hyaluronate, 0.08-0.12 parts of TREMELLA FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract, 0.74-0.96 parts of 1, 2-hexanediol, 0.4-0.6 parts of biogel-1, 0.4-0.6 parts of schizosaccharomyces cerevisiae fermentation product lysate, 0.4-0.6 parts of mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin, 0.16-0.24 parts of carnosine, 0.4-0.6 parts of acetyl octapeptide-3 and 0.8-1.2 parts of palmitoyl pentapeptide-4;
4-6 parts of humectant glycerin polyether-26;
0.32-0.48 part of thickener acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer;
the chelating agent is 0.024-0.036 parts of EDTA disodium;
the pH regulator is 0.32-0.48 part of triethanolamine;
the antioxidant is 0.4-0.6 part of p-hydroxyacetophenone;
the solvent is 72-108 parts of water.
5. The polypeptide anti-aging repair essence of claim 4, wherein the polypeptide anti-aging repair essence is characterized by comprising
The skin conditioner is selected from one or more of allantoin 0.18-0.22 parts, hydrolyzed sodium hyaluronate 0.09-0.11 parts, Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract 0.09-0.11 parts, 1, 2-hexanediol 0.72-0.88 parts, biogel-1 0.45-0.55 parts, split yeast fermentation product lysate 0.45-0.55 parts, mixture composed of ergothioneine, matsutake (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethyl hexyl glycerol 0.45-0.55 parts, carnosine 0.18-0.22 parts, acetyl octapeptide-3 0.45-0.55 parts, and palmitoyl pentapeptide-4 0.9-1.1 parts;
4.5-5.5 parts of humectant glycerin polyether-26;
0.36-0.44 part of thickener acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer;
the chelating agent is 0.027-0.033 parts of disodium EDTA;
the pH regulator is 0.36-0.44 parts of triethanolamine;
the antioxidant is 0.45-0.55 part of p-hydroxyacetophenone;
the solvent is 82-99 parts of water.
6. The polypeptide anti-aging repair essence according to claim 5, characterized in that
The skin conditioner is selected from one or more of the group consisting of 0.2 parts of allantoin, 0.1 parts of hydrolyzed sodium hyaluronate, 0.1 parts of TREMELLA FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract, 0.8 parts of 1, 2-hexanediol, 0.5 parts of bioglycan gum-1, 0.5 parts of schizosaccharomyces cerevisiae fermentation product lysate, 0.5 parts of a mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexylglycerin, 0.2 parts of carnosine, 0.5 parts of acetyl octapeptide-3 and 1 part of palmitoyl pentapeptide-4;
the humectant glycerin polyether-26 is 5 parts;
0.4 part of thickener acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer;
the chelating agent is 0.03 part of EDTA disodium;
the pH regulator is 0.4 part of triethanolamine;
the antioxidant is 0.5 part of p-hydroxyacetophenone;
the solvent is 89.27 parts of water.
7. A preparation method of polypeptide anti-aging repair essence is characterized by comprising the following steps:
step one, stirring phase A, heating to 86-94 ℃, preserving heat, sterilizing for 25-35 minutes, preferably 28-32 minutes, most preferably 30 minutes, and then cooling at constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin;
cooling the phase A in the step one to 62-67 ℃ at a constant speed, adding the preheated and dissolved phase A1, and stirring uniformly; the A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
step three, adding the A2 phase into the product obtained in the step two, stirring uniformly, and continuously cooling; the A2 phase is triethanolamine;
cooling the product obtained in the step three to 44-54 ℃, adding the dispersed phase B, and stirring and dissolving the mixture uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
step five, step four products are cooled to 35-43 ℃, and phase C is added, wherein the phase C comprises bioglycan-1, schizosaccharomyces cerevisiae fermentation product lysate, mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4; and stirring uniformly to obtain the polypeptide anti-aging repair essence.
8. The method for preparing the polypeptide anti-aging repair essence according to claim 7, wherein the preparation method comprises the following steps:
step one, stirring phase A, heating to 88-91 ℃, preserving heat, sterilizing for 28-32 minutes, and then cooling at constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin;
cooling the phase A in the step one to 64-66 ℃ at a constant speed, adding the preheated and dissolved phase A1, and stirring uniformly; the A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
step three, adding the A2 phase into the product obtained in the step two, stirring uniformly, and continuously cooling; the A2 phase is triethanolamine;
step four, when the product of the step three is cooled to 46-52 ℃, adding the dispersed phase B, and stirring and dissolving uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
step five, step four products are cooled to 37-40 ℃, and C phase is added, wherein the C phase comprises bioglycan-1, schizosaccharomyces cerevisiae fermentation product lysate, mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4; and stirring uniformly to obtain the polypeptide anti-aging repair essence.
9. The method for preparing the polypeptide anti-aging repair essence according to claim 8, wherein the preparation method comprises the following steps:
step one, stirring phase A, heating to 90 ℃, preserving heat, sterilizing for 30 minutes, and then cooling at a constant speed; the phase A comprises deionized water, acrylic acid (ester)/isodecyl acid vinyl ester cross-linked polymer, EDTA disodium and allantoin;
step two, cooling the phase A in the step one to 65 ℃, adding the preheated and dissolved phase A1, and stirring uniformly; the A1 phase comprises glyceryl polyether-26, p-hydroxyacetophenone, and 1, 2-hexanediol;
step three, adding the A2 phase into the product obtained in the step two, stirring uniformly, and continuously cooling; the A2 phase is triethanolamine;
step four, when the product of the step three is cooled to 50 ℃, adding the dispersed phase B, and stirring and dissolving uniformly; the phase B comprises glyceryl polyether-26, hydrolyzed sodium hyaluronate, and Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract;
step five, step four products are cooled to 38 ℃, and C phase is added, wherein the C phase comprises bioglycan-1, schizosaccharomyces cerevisiae fermentation product lysate, mixture consisting of ergothioneine, agaricus (ARMILLARIA MATSUTAKE) extract, 1, 2-pentanediol and ethylhexyl glycerol, carnosine, acetyl octapeptide-3 and palmitoyl pentapeptide-4; and stirring uniformly to obtain the polypeptide anti-aging repair essence.
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| CN115813776A (en) * | 2022-12-30 | 2023-03-21 | 杭州菲丝凯化妆品有限公司 | Essence with suspended particles and preparation method thereof |
| WO2023200874A1 (en) * | 2022-04-13 | 2023-10-19 | ALASTIN Skincare, Inc. | Combination of octapeptide and high molecular weight hyaluronic acid for topical application |
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