CN114569485B

CN114569485B - Eye cream containing liquid crystal structure and preparation method thereof

Info

Publication number: CN114569485B
Application number: CN202111274116.0A
Authority: CN
Inventors: 王冠煊; 艾晓淳
Original assignee: Zhongshan Zhongyan Cosmetic Co ltd
Current assignee: Zhongshan Zhongyan Cosmetic Co ltd
Priority date: 2021-10-29
Filing date: 2021-10-29
Publication date: 2024-01-26
Anticipated expiration: 2041-10-29
Also published as: CN114569485A

Abstract

The eye cream containing the liquid crystal structure is prepared from the following raw materials, by weight, 50-80 parts of eye cream base liquid, 20-30 parts of emulsion, 2-8 parts of humectant and 0.5-3 parts of thickener, wherein the eye cream base liquid comprises ceramide liposome, vitamin E, licorice extract, preservative and deionized water, and the emulsion is of a liquid crystal structure. The prepared eye cream has good high temperature resistance and low temperature resistance, is fresh and not greasy in use feeling, can repair skin around eyes, and has the effects of moisturizing, compacting and resisting wrinkles.

Description

Eye cream containing liquid crystal structure and preparation method thereof

Technical Field

The invention relates to the technical field of A61K8/68, in particular to eye cream containing a liquid crystal structure and a preparation method thereof.

Background

Eye care has a great proportion in daily skin care, various eye care products in the market are layered endlessly, but most of the eye care products are oily and thick in texture and are not easy to spread on the surface of skin, so that functional substances in the eye care products cannot well permeate into the skin, and the effect of relieving the problems of periocular wrinkles, dry lines, eye bags and the like is poor.

Chinese patent CN110960436a discloses an eye cream prepared by adding a liquid crystal emulsifier, which exhibits good heat and cold stability, and also has good moisturizing ability and compact permeation effect. Chinese patent CN112353725a discloses an eye cream added with ceramide liposome, which has effects of reducing dark circles and eye edema, improving rough and dry skin, etc. The invention provides an eye cream containing a liquid crystal structure and a preparation method thereof, wherein emulsion containing a stable natural liquid crystal structure is added into the eye cream, so that the stability of the eye cream and the bearing of active ingredients are improved, the absorption of the active ingredients in the eye cream is better promoted, and the eye cream has better effects of repairing skin around eyes, moisturizing and resisting wrinkles.

Disclosure of Invention

The first aspect of the invention provides eye cream containing a liquid crystal structure, which comprises the following raw materials in parts by weight: 50-80 parts of eye cream base liquid, 20-30 parts of emulsion, 2-8 parts of humectant and 0.5-3 parts of thickener.

In a preferred embodiment, the raw materials of the eye cream base solution comprise ceramide liposome, efficacy components, plant extracts, preservatives and deionized water; the functional component is at least one selected from vitamin E, retinol, sericin, panthenol and astaxanthin.

In a preferred embodiment, the efficacy component is vitamin E.

In a preferred embodiment, the plant extract is selected from at least one of licorice extract, rhodiola rosea extract, centella asiatica extract, green tea extract, dyer woad leaf extract, aloe extract, crape myrtle flower extract, grape seed extract, platycodon grandiflorum extract, and angelica dahurica extract.

In a preferred embodiment, the plant extract is a Glycyrrhiza extract, more preferably the Glycyrrhiza extract is a Glycyrrhiza glabra extract.

In a preferred embodiment, the eye cream base comprises, by mass, 0.5-5% of ceramide liposome, 1-3% of efficacy components, 0.1-0.5% of plant extracts, 0.1-0.5% of preservative and deionized water, wherein the balance is supplemented; more preferably, the eye cream base liquid comprises, by mass, 4% of ceramide liposome, 1.5% of efficacy components, 0.5% of plant extracts, 0.5% of preservatives and the balance of deionized water.

In the present application, the ceramide liposome is a hydrogenated lecithin-coated nano ceramide liposome, preferably purchased from the biological medicine technology limited company of Huzhou Pu Rui, and the active matter content is 20%; in the present application, the content of ceramide liposome is the active content of ceramide liposome.

In the experimental process, the eye cream prepared by adding the nano ceramide liposome wrapped by the hydrogenated lecithin shows more excellent stability, and the applicant speculates that the possible reasons are that the hydrogenated lecithin is tightly arranged and has certain rotational toughness, the hydrogenated lecithin improves the hydrophilicity of the liposome to a certain extent, and the emulsion of a liquid crystal structure bears the liposome and simultaneously the combined water existing between the liposome and the liquid crystal structure and hydrophilic groups on the liquid crystal structure act, so that the stability of the emulsion of the liquid crystal structure is improved, and the stability of the eye cream is further improved.

In the present application, the preservative is not particularly limited, and may be selected from at least one of phenoxyethanol, nibergold ester, methylparaben, propylparaben, octanediol, levulinic acid, p-hydroxyacetophenone, anisoic acid, but not limited thereto. Preferably, the preservative is p-hydroxyacetophenone and anisic acid in a mass ratio of 1:1.

In a preferred embodiment, the emulsion is a liquid crystal structured emulsion; the preparation raw materials of the liquid crystal structure emulsion comprise a high-carbon alcohol mixture, an emulsifying agent, an emollient, a viscosity regulator, a bacteriostatic agent and water.

In a preferred embodiment, the liquid crystal structure emulsion is prepared from the following raw materials, by weight, 2-5 parts of a high-carbon alcohol mixture, 1-3.5 parts of an emulsifying agent, 5-15 parts of an emollient, 3-7 parts of a viscosity regulator, 0.5-1.5 parts of a bacteriostatic agent and 70-80 parts of water.

More preferably, the liquid crystal structure emulsion is prepared from the following raw materials in parts by weight, including 3 parts of high-carbon alcohol mixture, 3.3 parts of emulsifier, 10 parts of emollient, 5.6 parts of viscosity regulator, 1.4 parts of bacteriostat and 76.7 parts of water.

In a preferred embodiment, the higher alcohol mixture is selected from higher alcohol mixtures having carbon atoms of from 14 to 22, more preferably, the higher alcohol mixture is hydrogenated rapeseed oil alcohol.

In a preferred embodiment, the emulsifier is a complex of a glycerol derivative and an amino acid stearoyl, more preferably the mass ratio of glycerol derivative to amino acid stearoyl is 10:1, and the amino acid stearoyl is preferably sodium stearoyl glutamate.

In a preferred embodiment, the glycerol derivative is a compound of a polyglyceryl ester derivative and a glyceride derivative, and more preferably, the glycerol derivative is a compound of polyglyceryl-10 pentastearate and monoglyceride in a mass ratio of 2:1.

In a preferred embodiment, the emollient is selected from at least one of caprylic/capric triglyceride, polydimethylsiloxane, cyclohexasiloxane, myristate, PEG-7 olive oleate, octyldodecanol, dioctylcyclohexane.

In a preferred embodiment, the viscosity modifier is at least one selected from the group consisting of glycerin, xanthan gum, sodium hyaluronate, trehalose, chitosan, and polymethyl cellulose. Preferably, the viscosity regulator is a compound substance of glycerol, xanthan gum and sodium hyaluronate, and the mass ratio is 5:0.5:0.1.

In a preferred embodiment, the bacteriostat is magnesium sulfate, phenoxyethanol and ethylhexyl glycerol, and the mass ratio is 0.5:0.8:0.1.

In a preferred embodiment, the humectant is selected from any one or a mixture of several of glycerin, butylene glycol, propylene glycol, panthenol, 1, 2-pentanediol, allantoin, saccharide isomers.

In a preferred embodiment, the humectant is a compound substance of panthenol and glycerin, and the mass ratio is 1: (3-5).

In a preferred embodiment, the thickener is selected from at least one of carbomers, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, xanthan gum, polyacrylate crosslinked polymer, tremella polysaccharide, and sclerotium gum.

In a preferred embodiment, the thickener is hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

The second aspect of the present invention provides a method for preparing an eye cream containing a liquid crystal structure, comprising the steps of:

(1) Preparing emulsion;

(2) Preparing eye cream: and uniformly stirring the eye cream base liquid, the humectant, the thickener and the emulsion to obtain the eye cream.

In a preferred embodiment, the emulsion is prepared as follows: heating the high-carbon alcohol mixture, the emulsifier and the emollient to 70-75 ℃ and stirring uniformly to obtain a premixed material, heating water and the viscosity regulator to 70-75 ℃ and stirring uniformly, adding the premixed material, homogenizing for 10min at 3000rpm, cooling to 38 ℃ after homogenizing, adding the bacteriostat, stirring uniformly, and discharging.

Compared with the prior art, the invention has the beneficial effects that:

1. the eye cream prepared by the invention is an eye cream containing a stable natural liquid crystal structure, has a stable liquid crystal structure and good high and low temperature resistance, and the stability of the liquid crystal structure and an eye cream system is further improved by adding the ceramide liposome wrapped by hydrogenated lecithin.

2. The eye cream prepared by the invention has fresh and non-greasy use feeling, and the added raw materials such as vitamin E, panthenol and the like can promote active ingredients to permeate into skin, so that the skin around the eyes is better repaired, and the effects of moisturizing, moistening, tightening and anti-wrinkle are achieved.

Detailed Description

Example 1

The first aspect of the embodiment provides an eye cream containing a liquid crystal structure, which is prepared from the following raw materials in parts by weight.

The eye cream base liquid comprises, by mass, 4% of ceramide liposome, 1.5% of vitamin E, 0.5% of licorice extract, 0.25% of p-hydroxyacetophenone, 0.25% of anisic acid and the balance of deionized water.

Ceramide liposomes were purchased from the biomedical technologies limited of Pu Rui in lake, with 20% active content. Glycyrrhiza glabra extract was purchased from the Sian super Bang Biotechnology Co., ltd, and glabridin content was 98%.

The emulsion is prepared from 3 parts by weight of hydrogenated rapeseed oil alcohol, 3.3 parts by weight of an emulsifier, 10 parts by weight of caprylic/capric triglyceride, 5.6 parts by weight of a viscosity regulator, 1.4 parts by weight of a bacteriostatic agent and 76.7 parts by weight of water.

The emulsifier is a compound substance of polyglycerol-10 pentastearate, sodium stearyl glutamate and monoglyceride, and the mass ratio is 2:0.3:1.

The viscosity regulator is a compound substance of glycerin, xanthan gum and sodium hyaluronate, and the mass ratio is 5:0.5:0.1.

The bacteriostat is magnesium sulfate, phenoxyethanol and ethylhexyl glycerol, and the mass ratio is 0.5:0.8:0.1.

Hydrogenated rapeseed oil alcohol was purchased from KOKYU, japan under the brand name: ALCOHOL NO.20-B.

Polyglycerol-10 pentastearate was purchased from Beijing Huamei reciprocity biochemical industry, CAS number 95461-64-6.

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer is purchased from kunskawa biotechnology limited, model: d1UL.

The second aspect of the present embodiment provides a method for preparing an eye cream containing a liquid crystal structure, which includes the following steps:

(1) Preparing emulsion: heating hydrogenated rapeseed oil alcohol, an emulsifier and caprylic/capric triglyceride to 70 ℃ and stirring uniformly to obtain a premixed material, heating water and a viscosity regulator to 70 ℃ and stirring uniformly, adding the premixed material, homogenizing for 10min at a homogenizing speed of 3000rpm, cooling to 38 ℃ after homogenizing is completed, adding a bacteriostat, stirring uniformly, and discharging.

(2) Preparing eye cream: and uniformly stirring the eye cream base solution, glycerol, panthenol, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and emulsion to obtain the eye cream.

Example 2

The first aspect of the embodiment provides an eye cream containing a liquid crystal structure, which is prepared from the following raw materials, by weight, 80 parts of eye cream base liquid, 28 parts of emulsion, 1.5 parts of panthenol, 4.5 parts of glycerol and 2.3 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

Example 3

The eye cream base liquid comprises, by mass, 4% of ceramide liposome, 1.5% of vitamin E, 0.25% of p-hydroxyacetophenone, 0.25% of anisic acid and the balance of deionized water.

Ceramide liposomes are purchased from sco biotechnology limited, inc under the trade name: NACARE CerasomeIII.

Example 4

The eye cream base liquid comprises, by mass, 4% of ceramide liposome, 0.5% of licorice extract, 0.25% of p-hydroxyacetophenone, 0.25% of anisic acid and the balance of deionized water.

Ceramide liposomes are purchased from sco biotechnology limited, inc under the trade name: NACARE CerasomeIII. Glycyrrhiza glabra extract was purchased from the Sian super Bang Biotechnology Co., ltd, and glabridin content was 98%.

Performance testing

1. The eye cream prepared in the example was subjected to stability test:

the eye cream with the same volume is placed in the environment of-18 ℃ and 5 ℃ and 48 ℃ for 1 month respectively, the appearance change of the eye cream is observed, and the eye cream with the same volume is subjected to 8 cyclic freezing and thawing processes respectively in the environment of-8 ℃ to 40 ℃ to observe the appearance change of the eye cream. The data are recorded in table 1.

TABLE 1

2. The eye cream prepared in the example was subjected to a moisturizing test:

the moisturizing test was performed with reference to QBT 4256-2011 cosmetic moisturizing efficacy evaluation guidelines.

60 volunteers were selected and randomly divided into 2 groups, one group of 30 persons tested the eye cream prepared in example 1, and the other group of 30 persons tested the eye cream prepared in example 4. Before the test, the volunteer needs to clean the inside of the forearm with water, wipe it clean with dry facial tissues, sit still for 30min in a room with a relative humidity of 50% at 25 ℃, and not drink water, keeping relaxed. And then, dividing the inner side of the forearm of the volunteer into 3 test areas on average, respectively using skin diagnosis Expert-DermaExpert MC760 moisture test probes to test the moisture values of the skin after the eye cream is not smeared, 30min is smeared, 2h is smeared and 4h is smeared, and calculating the moisture growth rate. The data are recorded in table 2. Moisture increase rate= (moisture value after application of eye cream-moisture value of not-applied eye cream)/moisture value of not-applied eye cream.

TABLE 2

	Example 1	Example 4
			Eye cream is smeared for 30min	32.79％	14.65％
Eye cream is smeared for 2h	31.27％	10.87％
			Eye cream is smeared for 4 hours	20.63％	8.24％

Claims

1. An eye cream containing a liquid crystal structure is characterized by comprising the following preparation raw materials in parts by weight: comprises 72 parts of eye cream basic solution, 22 parts of emulsion, 1 part of panthenol, 3.5 parts of glycerol and 1.5 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;

the eye cream base liquid comprises, by mass, 4% of ceramide liposome, 1.5% of vitamin E, 0.5% of licorice extract, 0.25% of p-hydroxyacetophenone, 0.25% of anisic acid and the balance of deionized water; the ceramide liposome is purchased from the biological medicine technology limited company of Huzhou Pu Rui, and the content of active substances is 20%; the glabridin extract is purchased from the Sian super-bang biotechnology Co., ltd, and the glabridin content is 98%;

the emulsion is prepared from the following raw materials in parts by weight, including 3 parts of hydrogenated rapeseed oil alcohol, 3.3 parts of emulsifier, 10 parts of caprylic/capric triglyceride, 5.6 parts of viscosity regulator, 1.4 parts of bacteriostat and 76.7 parts of water;

the emulsifier is a compound substance of polyglycerol-10 pentastearate, sodium stearoyl glutamate and monoglyceride, and the mass ratio is 2:0.3:1;

the viscosity regulator is a compound substance of glycerol, xanthan gum and sodium hyaluronate, and the mass ratio is 5:0.5:0.1;

the bacteriostat is magnesium sulfate, phenoxyethanol and ethylhexyl glycerol, and the mass ratio is 0.5:0.8:0.1;

the preparation method of the eye cream comprises the following steps:

(1) Preparing emulsion: heating hydrogenated rapeseed oil alcohol, an emulsifier and caprylic/capric triglyceride to 70 ℃ and stirring uniformly to obtain a premixed material, heating water and a viscosity regulator to 70 ℃ and stirring uniformly, adding the premixed material, homogenizing for 10min at a homogenizing speed of 3000rpm, cooling to 38 ℃ after homogenizing is completed, adding a bacteriostat, stirring uniformly, and discharging;