CN114569485A

CN114569485A - Eye cream containing liquid crystal structure and preparation method thereof

Info

Publication number: CN114569485A
Application number: CN202111274116.0A
Authority: CN
Inventors: 王冠煊; 艾晓淳
Original assignee: Zhongshan Zhongyan Cosmetic Co ltd
Current assignee: Zhongshan Zhongyan Cosmetic Co ltd
Priority date: 2021-10-29
Filing date: 2021-10-29
Publication date: 2022-06-03
Anticipated expiration: 2041-10-29
Also published as: CN114569485B

Abstract

The invention provides an eye cream containing a liquid crystal structure and a preparation method thereof, wherein the preparation raw materials comprise, by weight, 50-80 parts of an eye cream base solution, 20-30 parts of an emulsion, 2-8 parts of a humectant and 0.5-3 parts of a thickening agent, wherein the eye cream base solution comprises ceramide liposome, vitamin E, a Glycyrrhiza glabra extract, a preservative and deionized water, and the emulsion is an emulsion with a liquid crystal structure. The prepared eye cream has good high-temperature resistance and low-temperature resistance, is fresh and cool in use feeling and not greasy, can repair skin around eyes, and has the effects of moisturizing, firming and resisting wrinkles.

Description

Eye cream containing liquid crystal structure and preparation method thereof

Technical Field

The invention relates to the technical field of A61K8/68, in particular to eye cream containing a liquid crystal structure and a preparation method thereof.

Background

Eye nursing occupies a great proportion in daily skin nursing, various eye nursing products are available on the market, but most eye nursing products are greasy and heavy in texture, are not easy to spread on the surface of skin, so that functional substances in the eye nursing products cannot well permeate into the skin, and the eye nursing products have poor effect on relieving the problems of wrinkles around eyes, dry lines, pouches and the like.

Chinese patent CN110960436A discloses an eye cream prepared by adding a liquid crystal emulsifier, which shows good heat-resistant and cold-resistant stability, and also has good moisturizing capability and tightening and penetrating effects. Chinese patent CN112353725A discloses an eye cream added with ceramide liposome, which has the effects of lightening dark eye circles and eye edema, improving the phenomenon of rough and dry skin and the like. The invention provides eye cream with a liquid crystal structure and a preparation method thereof.

Disclosure of Invention

The invention provides eye cream containing a liquid crystal structure in a first aspect, which comprises the following raw materials in parts by weight: 50-80 parts of eye cream base liquid, 20-30 parts of emulsion, 2-8 parts of humectant and 0.5-3 parts of thickener.

In a preferred embodiment, the raw materials of the eye cream base solution comprise ceramide liposome, efficacy components, plant extracts, preservatives, deionized water; the functional component is at least one of vitamin E, retinol, sericin, panthenol and astaxanthin.

In a preferred embodiment, the efficacy component is vitamin E.

In a preferred embodiment, the plant extract is at least one selected from the group consisting of licorice extract, rhodiola extract, centella extract, green tea extract, isatis leaf extract, aloe extract, crape myrtle flower extract, grape seed extract, platycodon root extract, and angelica dahurica extract.

In a preferred embodiment, the plant extract is a glycyrrhiza extract, more preferably, the glycyrrhiza extract is a glycyrrhiza glabra extract.

In a preferred embodiment, the raw materials of the eye cream base solution comprise, by mass percentage, 0.5-5% of ceramide liposome, 1-3% of efficacy components, 0.1-0.5% of plant extracts, 0.1-0.5% of preservatives and deionized water to supplement the balance; more preferably, the raw materials of the eye cream base solution comprise, by mass, 4% of ceramide liposome, 1.5% of efficacy components, 0.5% of plant extract, 0.5% of preservative and the balance of deionized water.

In the present application, the ceramide liposome is a hydrogenated lecithin-coated nano ceramide liposome, preferably purchased from purley biomedical technology, limited, lazhou, and has an active matter content of 20%; in the present application, the content of ceramide liposome is the content of ceramide liposome active substance.

In the experimental process, the eye cream prepared by adding the hydrogenated lecithin-coated nano ceramide liposome is found to show more excellent stability, and the applicant conjectures that the hydrogenated lecithin is closely arranged and has certain rotational toughness, the hydrophilicity of liposome is improved to a certain extent by the hydrogenated lecithin, and the combination water existing between the liposome and the liquid crystal structure and the hydrophilic group on the liquid crystal structure act while the emulsion of the liquid crystal structure bears the liposome, so that the stability of the emulsion of the liquid crystal structure is improved, and the stability of the eye cream is further improved.

In the present application, the preservative is not particularly limited, and may be selected from, but not limited to, at least one of phenoxyethanol, paraben, methylparaben, propylparaben, octanediol, levulinic acid, p-hydroxyacetophenone, and anisic acid. Preferably, the preservative is p-hydroxyacetophenone and anisic acid in a mass ratio of 1: 1.

In a preferred embodiment, the emulsion is a liquid crystal structure emulsion; the raw materials for preparing the liquid crystal structure emulsion comprise a high-carbon alcohol mixture, an emulsifier, an emollient, a viscosity regulator, a bacteriostatic agent and water.

In a preferred embodiment, the raw materials for preparing the liquid crystal structure emulsion comprise, by weight, 2-5 parts of a higher alcohol mixture, 1-3.5 parts of an emulsifier, 5-15 parts of an emollient, 3-7 parts of a viscosity regulator, 0.5-1.5 parts of a bacteriostatic agent and 70-80 parts of water.

More preferably, the raw materials for preparing the liquid crystal structure emulsion comprise, by weight, 3 parts of a higher alcohol mixture, 3.3 parts of an emulsifier, 10 parts of an emollient, 5.6 parts of a viscosity regulator, 1.4 parts of a bacteriostatic agent and 76.7 parts of water.

In a preferred embodiment, the higher alcohol mixture is selected from the group consisting of higher alcohol mixtures having a carbon number of C14-22, and more preferably, the higher alcohol mixture is hydrogenated rapeseed oleyl alcohol.

In a preferred embodiment, the emulsifier is a compound substance of a glycerol derivative and an amino acid stearoyl, more preferably the mass ratio of the glycerol derivative to the amino acid stearoyl is 10:1, and the amino acid stearoyl is preferably sodium stearoyl glutamate.

In a preferred embodiment, the glycerol derivative is a compound of a polyglycerol ester derivative and a glycerol ester derivative, and more preferably, the glycerol derivative is a compound of polyglycerol-10 pentastearate and monoglyceride in a mass ratio of 2: 1.

In a preferred embodiment, the emollient is selected from at least one of caprylic/capric triglyceride, dimethicone, cyclohexasiloxane, myristyl myristate, PEG-7 olive oleate, octyldodecanol, dioctylcyclohexane.

In a preferred embodiment, the viscosity modifier is selected from at least one of glycerol, xanthan gum, sodium hyaluronate, trehalose, chitosan, and polymethylcellulose. Preferably, the viscosity regulator is a compound substance of glycerol, xanthan gum and sodium hyaluronate, and the mass ratio is 5:0.5: 0.1.

In a preferred embodiment, the bacteriostatic agent is magnesium sulfate, phenoxyethanol and ethylhexyl glycerin in a mass ratio of 0.5:0.8: 0.1.

In a preferred embodiment, the humectant is selected from any one or a mixture of glycerol, butylene glycol, propylene glycol, panthenol, 1, 2-pentanediol, allantoin, saccharide isomers.

In a preferred embodiment, the humectant is a compound substance of panthenol and glycerin, and the mass ratio of the panthenol to the glycerin is 1: (3-5).

In a preferred embodiment, the thickener is selected from at least one of carbomer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, xanthan gum, polyacrylate cross-linked polymer, tremella polysaccharide, sclerotium rolfsii gum.

In a preferred embodiment, the thickener is a hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

The invention provides a preparation method of eye cream containing a liquid crystal structure in a second aspect, which comprises the following steps:

(1) preparing an emulsion;

(2) preparing eye cream: and uniformly stirring the eye cream base solution, the humectant, the thickener and the emulsion to obtain the eye cream.

In a preferred embodiment, the emulsion is prepared as follows: heating the high-carbon alcohol mixture, the emulsifier and the emollient to 70-75 ℃, uniformly stirring to obtain a premixed material, heating the water and the viscosity regulator to 70-75 ℃, uniformly stirring, adding the premixed material, homogenizing for 10min at the speed of 3000rpm, cooling to 38 ℃ after homogenizing, adding the bacteriostatic agent, uniformly stirring, and discharging.

Compared with the prior art, the invention has the following beneficial effects:

1. the eye cream prepared by the invention is an eye cream containing a stable natural liquid crystal structure, the liquid crystal structure is stable, the high-temperature resistance and low-temperature resistance are good, and the stability of the liquid crystal structure and an eye cream system is further improved by adding the ceramide liposome wrapped by the hydrogenated lecithin.

2. The eye cream prepared by the invention is fresh and cool in use feeling and not greasy, and the added raw materials such as vitamin E, panthenol and the like can promote active ingredients to permeate into skin, better repair skin around eyes and play the effects of moisturizing, firming and resisting wrinkles.

Detailed Description

Example 1

In the first aspect of this embodiment, an eye cream containing a liquid crystal structure is provided, and the raw materials for preparation include, by weight, 72 parts of an eye cream base solution, 22 parts of an emulsion, 1 part of panthenol, 3.5 parts of glycerin, and 1.5 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

The raw materials of the eye cream base solution comprise, by mass, 4% of ceramide liposome, 1.5% of vitamin E, 0.5% of Glycyrrhiza glabra extract, 0.25% of p-hydroxyacetophenone, 0.25% of anisic acid and the balance of deionized water.

Ceramide liposome was purchased from pury biomedical technology, inc, lazhou with an active content of 20%. Glycyrrhiza glabra extract was purchased from biosciences, Chailan, Inc., and the content of glabridin was 98%.

The raw materials for preparing the emulsion comprise, by weight, 3 parts of hydrogenated rapeseed oleyl alcohol, 3.3 parts of an emulsifier, 10 parts of caprylic/capric triglyceride, 5.6 parts of a viscosity regulator, 1.4 parts of a bacteriostatic agent and 76.7 parts of water.

The emulsifier is a compound substance of polyglycerol-10 pentastearate, sodium stearyl glutamate and monoglyceride, and the mass ratio is 2:0.3: 1.

The viscosity regulator is a compound substance of glycerol, xanthan gum and sodium hyaluronate, and the mass ratio is 5:0.5: 0.1.

The bacteriostatic agent is magnesium sulfate, phenoxyethanol and ethyl hexyl glycerol, and the mass ratio is 0.5:0.8: 0.1.

Hydrogenated rapeseed oleyl alcohol was purchased from KOKYU, japan, trade mark: ALCOOL NO. 20-B.

Polyglycerol-10 pentastearate was purchased from the beijing Huameili biochemical industry, CAS number 95461-64-6.

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer was purchased from Kunshan sandian Biotechnology Co., Ltd, model number: d1 UL.

In a second aspect, this embodiment provides a method for preparing an eye cream containing a liquid crystal structure, comprising the following steps:

(1) preparing an emulsion: heating hydrogenated rapeseed oleyl alcohol, an emulsifier and caprylic/capric triglyceride to 70 ℃, uniformly stirring to obtain a premixed material, heating water and a viscosity regulator to 70 ℃, uniformly stirring, adding the premixed material, homogenizing for 10min at the speed of 3000rpm, cooling to 38 ℃ after homogenizing, adding a bacteriostatic agent, uniformly stirring, and discharging.

(2) Preparing eye cream: and uniformly stirring the eye cream base solution, the glycerol, the panthenol, the hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer and the emulsion to obtain the eye cream.

Example 2

In the first aspect of this embodiment, an eye cream containing a liquid crystal structure is provided, and the raw materials for preparation comprise, by weight, 80 parts of an eye cream base solution, 28 parts of an emulsion, 1.5 parts of panthenol, 4.5 parts of glycerol, and 2.3 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer was purchased from sandansan biotechnology limited, model number: d1 UL.

Example 3

The eye cream base solution comprises 4% of ceramide liposome, 1.5% of vitamin E, 0.25% of p-hydroxyacetophenone, 0.25% of anisic acid and the balance of deionized water in percentage by mass.

Ceramide liposomes are available from nakang biotech ltd, suzhou under the trade name: NACARE Cerasome III.

Hydrogenated rapeseed oleyl alcohol was purchased from KOKYU, japan, brand: ALCOOL NO. 20-B.

Example 4

In the first aspect of the present embodiment, an eye cream containing a liquid crystal structure is provided, and the preparation raw materials include, by weight, 72 parts of an eye cream base solution, 22 parts of an emulsion, 1 part of panthenol, 3.5 parts of glycerol, and 1.5 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

The raw materials of the eye cream base solution comprise, by mass, 4% of ceramide liposome, 0.5% of glycyrrhiza glabra extract, 0.25% of p-hydroxyacetophenone, 0.25% of anisic acid and the balance of deionized water.

Ceramide liposomes are available from nakang biotech ltd, suzhou under the trade name: NACARE Cerasome III. Glycyrrhiza glabra extract was purchased from biosciences, Chailan, Inc., and the content of glabridin was 98%.

The bacteriostatic agent is magnesium sulfate, phenoxyethanol and ethylhexyl glycerin with the mass ratio of 0.5:0.8: 0.1.

Performance testing

1. The eye creams prepared in the examples were subjected to stability tests:

respectively placing the eye creams with the same volume in an environment of-18 ℃, 5 ℃ and 48 ℃ for 1 month, observing the appearance change of the eye creams, respectively carrying out 8 circulating freeze-thaw processes on the eye creams with the same volume in the environment of-8 ℃ to 40 ℃ and observing the appearance change of the eye creams. The data are recorded in table 1.

TABLE 1

2. The eye creams prepared in the examples were subjected to a moisturizing test:

the moisture retention test is carried out by referring to QBT 4256-2011 cosmetic moisture retention efficacy evaluation guideline.

60 volunteers were selected and randomly divided into 2 groups, one group of 30 persons tested the eye cream prepared in example 1, and the other group of 30 persons tested the eye cream prepared in example 4. Before the test, the volunteers need to clean the inner side of the forearm with water, wipe the forearm with dry facial tissue, sit still in a room with a relative humidity of 50% at 25 ℃ for 30min, cannot drink water, and keep relaxed. Then, the inner side of the front arm of the volunteer is divided into 3 test areas on average, the moisture values of the skin without being coated with eye cream, after being coated with the eye cream for 30min, after being coated with the eye cream for 2h and after being coated with the eye cream for 4h are tested by respectively applying a skin diagnosis Expert-Derma Expert MC760 moisture test probe, and the moisture increase rate is calculated. The data are recorded in table 2. The moisture increase rate (moisture value after the eye cream is applied-moisture value of the eye cream not applied)/moisture value of the eye cream not applied.

TABLE 2

	Example 1	Example 4
			Applying eye cream for 30min	32.79％	14.65％
Applying eye cream for 2h	31.27％	10.87％
			Applying eye cream for 4h	20.63％	8.24％

Claims

1. The eye cream containing the liquid crystal structure is characterized by comprising the following preparation raw materials in parts by weight: 50-80 parts of eye cream base liquid, 20-30 parts of emulsion, 2-8 parts of humectant and 0.5-3 parts of thickener.

2. The eye cream containing liquid crystal structure as claimed in claim 1, wherein the raw materials of the eye cream base solution comprise ceramide liposome, efficacy component, plant extract, preservative, deionized water;

the functional component is at least one selected from tocopherol, retinol, sericin, panthenol and astaxanthin.

3. Eye cream with liquid crystal structure according to claim 2, characterized in that the ceramide liposome is a hydrogenated lecithin encapsulated nano ceramide liposome.

4. Eye cream containing liquid crystalline structures according to claim 1, characterized in that the emulsion is a liquid crystalline structure emulsion;

the raw materials for preparing the liquid crystal structure emulsion comprise a high-carbon alcohol mixture, an emulsifier, an emollient, a viscosity regulator, a bacteriostatic agent and water.

5. The eye cream containing a liquid crystal structure according to claim 4, wherein the emulsifier is a compound substance of a glycerol derivative and an amino acid stearyl group.

6. Eye cream containing liquid crystal structures according to claim 4, characterized in that the higher alcohol mixture is selected from higher alcohol mixtures with a number of carbon atoms from C14 to C22.

7. Eye cream with liquid crystal structure according to claim 1, characterized in that the humectant is selected from any one or a mixture of several of glycerol, butylene glycol, propylene glycol, panthenol, 1, 2-pentanediol, allantoin, saccharide isomers.

8. Eye cream with a liquid crystalline structure according to claim 1, characterized in that the thickener is selected from at least one of carbomer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, xanthan gum, polyacrylate crosspolymer, sclerosant, tremella polysaccharide.

9. Eye cream containing a liquid crystalline structure according to claim 8, characterized in that the thickener is hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

10. A method for preparing an eye cream containing a liquid crystal structure according to any one of claims 1 to 9, comprising the steps of:

(1) preparing an emulsion;