CN111658555A

CN111658555A - Nano anti-wrinkle essence cream and preparation method thereof

Info

Publication number: CN111658555A
Application number: CN202010689798.0A
Authority: CN
Inventors: 张�杰; 陈婷婷
Original assignee: Intercos Technology Sip Co ltd
Current assignee: Intercos Technology Sip Co ltd
Priority date: 2020-07-17
Filing date: 2020-07-17
Publication date: 2020-09-15

Abstract

The invention relates to the technical field of skin care products, and discloses a nano anti-wrinkle essence cream and a preparation method thereof; the nano anti-wrinkle essence milk comprises the following components in percentage by weight: 60% -70% of water; 10% -20% of glycerin; 10% -20% of methyl propylene glycol; 1% -6% of an emulsifier; 5% -15% of a grease emollient; 0.01 to 0.5 percent of ceramide; 0.05 to 0.3 percent of pH regulator; 0.01 to 0.5 percent of tetrahydro-methyl pyrimidine carboxylic acid; 0.05-2% of saccharide isomer. The preparation method of the nano anti-wrinkle essence emulsion comprises the steps of mixing a first water phase and a thickening agent to form a uniform system, adding an oil phase under the condition of stirring and homogenizing, wherein the formed product is an O/W type emulsification system, dissolving and stirring the added oil phase to eliminate internal solutes and form a uniform dispersed phase oil phase, and mixing the dispersed phase oil phase with a mixed water phase, so that the water phase and the oil phase are quickly mixed at intervals, and the fluidity of the mixture is improved to enable the mixture to be more viscous and moist.

Description

Nano anti-wrinkle essence cream and preparation method thereof

Technical Field

The invention relates to the technical field of skin care products, and particularly relates to a nano anti-wrinkle essence cream and a preparation method thereof.

Background

The skin is an important organ of the human body, has a complex tissue structure, is closely connected with other organs of the human body, plays a role of a barrier and protects the human body from external stimulation and injury. With the continuous innovation of skin care products and pharmaceutical technology, natural, safe, environment-friendly and functional skin care products are more and more popular with consumers. In recent years, with the improvement of living standard of people, the market share of anti-wrinkle products shows a growing trend year by year.

The skin-care cream product is a main product in skin care products, belongs to an emulsification system, mainly comprises grease, an emulsifier, a rheology regulator, a humectant, a preservative, an antioxidant, essence, a chelating agent, a colorant and other active components, and the main active components in the current market comprise: the preparation method has low preparation efficiency, and meanwhile, the prepared skin care cream product is not easy to permeate the skin, so that the absorption shrinkage rate of the skin is reduced.

Disclosure of Invention

The invention aims to provide a nano anti-wrinkle essence cream and a preparation method thereof, the particle size of the emulsion prepared by adopting an emulsifier is 200nm, the emulsion is beneficial to the penetration of active substances and has higher absorption speed, and the skin can absorb nutrients in the essence cream conveniently, so that the used skin is more tender and white, and the problem that the existing emulsification system preparation method is low in preparation efficiency, and meanwhile, the prepared skin-care cream product is not easy to penetrate the skin, so that the skin absorption shrinkage rate is reduced is solved.

According to the embodiment of the invention, the nano anti-wrinkle essence milk comprises the following components in percentage by weight:

on the basis of the scheme, the anti-wrinkle essence milk further comprises the following components in percentage by weight: 0.0001 to 0.1 percent of ergothioneine.

On the basis of the scheme, the anti-wrinkle essence milk further comprises the following components in percentage by weight: 0.001-0.1% of artichoke leaf extract.

On the basis of the scheme, the anti-wrinkle essence milk further comprises the following components in percentage by weight: palmitoyl tripeptide-50.0001% -0.1%.

On the basis of the scheme, the emulsifier is one or two of PEG-20 methyl glucose sesquistearate, sunflower seed oil glyceride, caprylyl glycine and lauroyl wheat amino acid potassium.

On the basis of the scheme, the oil and fat emollient is one or more of meadowfoam seed oil, isononyl isononanoate, dioctyl carbonate, cetearyl alcohol and cyclopentadimethylsiloxane.

On the basis of the scheme, the anti-wrinkle essence milk further comprises the following components in percentage by weight: 0.5 to 2 percent of preservative.

The preservative is a mixture of phenoxyethanol, 1, 2 hexanediol and caprylyl hydroximic acid.

A preparation method of nano anti-wrinkle essence milk specifically comprises the following steps:

s1: weighing glycerol, methyl propylene glycol and a preservative according to the weight percentage, and adding part of water to mix and stir to form a first water phase;

s2: then adding an emulsifier into the first water phase prepared in S1, mixing and stirring for 10-15min to form a mixed water phase;

s3: placing the mixed water phase at 80-90 deg.C, and adding oil emollient into the mixed water phase to mix well;

s4: and (3) adding the tetrahydro-methyl pyrimidine carboxylic acid after uniformly mixing, then cooling to 40-50 ℃, adding the rest raw materials and the rest water, uniformly mixing, and cooling to room temperature to obtain the nano anti-wrinkle essence milk.

In S3, the oil emollient is first heated, mixed and dissolved at 40-60 deg.c to dissolve the internal solute and form a homogeneously dissolved dispersed phase oil phase, and then the homogeneously dissolved dispersed phase oil phase is added to the mixed aqueous phase.

The saccharide isomerate has good instant and long-acting moisturizing effect; ceramide can effectively improve the lipid structure of stratum corneum, so that the ceramide has good effect of enhancing the skin barrier; ergothioneine and Armillaria matsutake extract has effects of resisting oxidation, resisting photoaging, protecting DNA and mitochondria, improving skin elasticity, and improving mottle; the tetrahydro-methyl pyrimidine carboxylic acid has the functions of improving the stress capability of cells, protecting Langerhans cells, enhancing the immune function of skin and protecting DNA from being damaged by ultraviolet rays and visible light; the Cynara scolymus leaf extract obtained by sustainable method is effective in promoting skin microcirculation, reducing lymphatic permeability, maintaining fibroblast function and life, improving skin firmness and elasticity, and reducing wrinkles and skin roughness; palmitoyl tripeptide-5 is a TGF-beta promoter, can effectively promote the generation of skin collagen, and can prevent the degradation of the collagen.

Compared with the prior art, the invention has the beneficial effects that:

1. the preparation method of the nano anti-wrinkle essence emulsion comprises the steps of mixing a first water phase and a thickening agent to form a uniform system, adding an oil phase under the condition of stirring and homogenizing, wherein the formed product is an O/W type emulsification system, dissolving and stirring the added oil phase to eliminate internal solutes, forming a uniform dispersed phase oil phase, and mixing the dispersed phase oil phase with a mixed water phase, so that the water phase and the oil phase are quickly mixed, and the fluidity of the mixture is improved to enable the mixture to be more viscous and moist;

2. the emulsion prepared by the emulsifier has the particle size of 200nm, is beneficial to the penetration of active substances, has a faster absorption speed, and is convenient for the skin to absorb nutrients in the essence emulsion, so that the used skin is more tender and white.

Drawings

Fig. 1 is a particle size distribution diagram of an ordinary temperature sample of comparative example essence milk according to the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The features and properties of the present application are described in further detail below with reference to examples.

Example 1

The nanometer anti-wrinkle essence milk comprises the following components in percentage by weight:

the L-ergothioneine is obtained by regulating and controlling the accurate metabolism of the mixed fermentation of the agaricus and the hericium erinaceus, and the method can obtain the L-ergothioneine with high concentration;

cynara scolymus leaf extract 0.001%;

palmitoyl tripeptide-50.0001%;

0.5 percent of preservative.

The emulsifier is PEG-20 methyl glucose sesquistearate and sunflower seed oil glyceride with the mixing ratio of 2: 1.

The oil emollient is white chinlon oil.

The preservative is a mixture of phenoxyethanol, 1, 2 hexanediol and caprylyl hydroximic acid, and the mixing ratio is 1:1: 1.

Example 2

the L-ergothioneine is obtained by precise metabolic regulation and control of mixed fermentation of agaricus and hericium, and the method can obtain high-concentration L-ergothioneine;

cynara scolymus leaf extract 0.1%;

palmitoyl tripeptide-50.1%;

2 percent of preservative.

The emulsifier is PEG-20 methyl glucose sesquistearate.

The oil and fat emollient is a mixture of meadowfoam seed oil, isononyl isononanoate, dioctyl carbonate, cetostearyl alcohol and cyclopentadimethylsiloxane, and the mixing ratio is 1:2:1: 2.

The preservative is a mixture of phenoxyethanol, 1, 2 hexanediol and caprylyl hydroximic acid, and the mixing ratio is 2:1: 2.

The performance of the nano anti-wrinkle essence milk of the examples of the present application is tested by the following tests (examples 1-2 and comparative examples 1-5, wherein comparative examples 1-4 are all prior art essence milk products).

Comparative example

First, stability detection

The test process comprises the following steps:

in 2019, 1 month, seven products are respectively placed under the following conditions and the recorded results are observed,

and record the oil droplet size:

through experiments, stable nano emulsion can be formed by using the potassium lauroyl wheat amino acid composite emulsifier, and the figure 1 is a particle size distribution diagram of a sample at the normal temperature.

Second, texture detection

The test process comprises the following steps:

evaluation method of skin feel global impression: in 2019, the nano anti-wrinkle essence milks of the examples and the comparative examples are provided to 20 randomly selected female volunteers for trial use for one week and are distributed to electronic evaluation sheets of the volunteers through a social platform. The following indexes of the product are evaluated respectively, and according to 1-5 points, the texture detection total impression average value is equal to the weight/weight sum corresponding to each index score multiplied by the total statistical average value; the evaluation criteria are shown in the following table:

evaluation index	Evaluation criteria	Weight of
			Degree of freshness	Greasy feeling-very fresh and cool (1-5)	20
Moistening and moistening	Dryness-moistening (1-5)	20
			Sense of touch and bounce	Sticky feeling-good elasticity (1-5)	20
Degree of spreading	Difficult to push open- -easy to spread (1-5)	20
			Sensation of absorption	Very slow absorption- -very fast absorption	20

Refreshing degree; after the product is applied to absorb the skin, the more obvious the refreshing degree of the skin is, the higher the score is;

moistening; after the product is applied to the skin for absorption, the skin feels not dry, the skin does not feel tight, the skin feels rich, and the more obvious the feeling is, the higher the score is;

a sense of touch; the more the product is in the stage of extrusion and rubbing on the hand, the higher the bullet score is;

spreading degree; the product has better uniformity when in use, is not easy to adhere to large sheets, and has more obvious effect.

The absorption feeling is as follows: the faster the product is absorbed in use, the higher the score

The detection results are shown in the following chart:

from the above table, the products of examples 1 and 2 of the present application have good skin feel, good spreadability when applied, high skin-fit, fast absorption, and no sticky feel.

Third, moisture retention effect detection

Test time: year 2019, month 5 and day 7.

The purpose of the test is as follows: and testing and evaluating the moisturizing efficacy within 8 hours after the product is used.

The subject: 5 names of the Chinese characters.

The test method comprises selecting the curved side of forearm of subject to be 2 × 2cm²Seven places were selected on the two arms (for seven experimental examples), and after cleaning, the product was applied to the area to be tested. The measurement of the stratum corneum moisture content of the area to be tested was carried out using a Corneometer (skin moisture tester) at 0h, 4h and 8h before and after use, respectively. The same site was measured 5 times, and 3 averages were taken after excluding the maximum and minimum values and recorded. Values are the average of 5 subjects.

Parameter interpretation: the greater the stratum corneum moisture content value (CORNE), the higher the skin stratum corneum moisture content.

As can be seen from the graph, the product obtained by the method of the present application, which is provided in example 1, exhibited a horny layer moisture growth rate of 67% after use and still exhibited a horny layer moisture growth rate of 48% after 8 hours of use. It can be seen that the product provided by the embodiment of the application has instant and 8-hour moisturizing effects.

The experimental data of example 2 also show the same effects as those of example 1.

Moreover, the contents of the specific components are summarized in the comparative examples, and the effects of the components are omitted.

Among others, mention may be made of:

in comparative example 1, ceramide 2 and saccharide isomer were absent, so that the moisturizing effect was significantly insufficient, and it was apparent that both the moisturizing effect and the moisturizing effect were inferior to those of examples 1 and 2 with reference to data of 0h after use (horny layer moisture increase rate of 47%) and 8h after use (horny layer moisture increase rate of 19%).

In comparative example 5, in which the composite nanoemulsion (sunflower seed oil glycerides, caprylyl glycine, potassium lauroyl wheat amino acid, water) is absent, the corresponding data of 0h after use (the water increase rate of the horny layer is 45%) and 8h after use (the water increase rate of the horny layer is 34%) are poor in both the moisturizing effect and the moisturizing effect compared to example 1.

Comparative examples 2, 3 and 4, which lack ergothioneine, artichoke leaf extract and palmitoyl tripeptide-5, and tetrahydro-methylpyrimidine carboxylic acid, respectively, show that they have a better moisturizing effect, although slightly inferior to that of example 1.

Fourth, detection of water loss rate effect of epidermis

Test time: year 2019, month 5, and day 17.

The subject: 5 names of the Chinese characters.

The test method comprises selecting the curved side of forearm of subject to be 2 × 2cm²Seven places were selected on the two arms (for seven experimental examples), and after cleaning, the product was applied to the area to be tested. The measurement of the water content of the stratum corneum of the area to be tested was carried out using a Tewameter TM300 (transepidermal water loss tester) before and 4h and 8h after use, respectively. The same site was measured 5 times, and 3 averages were taken after excluding the maximum and minimum values and recorded.

Parameter interpretation: the smaller the trans-epidermal water loss value (TEWL), the less the skin epidermal water loss and the better the skin barrier.

As can be seen from the graph, the product prepared by the preparation method provided in example 1 of the present application has a water loss rate through the epidermis of 33% after 4 hours of use and 27% after 8 hours of use. It can be seen that the products provided by the examples of the present application have the function of enhancing the skin barrier.

Among others, mention may be made of:

the comparative example 1 lacks ceramide and saccharide isomers, and thus is significantly insufficient in the skin barrier function improvement effect, and it is apparent that the skin barrier function improvement effect is slightly inferior to that of examples 1 and 2, with reference to data of 4h after use (15% reduction in the epidermal water loss rate) and 8h after use (11% reduction in the epidermal water loss rate).

In comparative example 5, in which the composite nanoemulsion (sunflower seed oil glycerides, caprylyl glycine, potassium lauroyl wheat amino acid, water) was absent, it can be seen from the data that the skin barrier function improvement effect was slightly inferior compared to examples 1 and 2, in the data of 4 hours after use (the water loss rate through the epidermis was reduced by 23%) and 8 hours after use (the water loss rate through the epidermis was reduced by 13%).

Comparative examples 2, 3, 4, lacking ergothioneine, artichoke leaf extract and palmitoyl tripeptide-5, tetrahydromethylpyrimidine carboxylic acid, respectively, still had some skin barrier improvement effect, and the final use effect was slightly inferior to example 1/2.

Wrinkle test

Test time: 6 months and 1 day 2019.

The purpose of the test is as follows: the product was tested for wrinkle improvement.

The subject: 16 names.

The test method comprises the following steps: local wrinkle changes were analyzed by Visia-CR image contrast

The using method comprises the following steps: subjects were divided into four groups of 4, each group using one product, method of use: the medicine is taken in the morning and at night every day, and is visited again after 4W, and the questionnaire is filled.

According to data analysis, the product prepared by the preparation method provided by the application example 1 has obvious improvement on local wrinkles after 2W and 4W are used.

Among others, mention may be made of:

comparative example 1 lacks ceramide 2 and saccharide isomers, and is thus significantly insufficient in skin barrier function improvement and moisturizing effects, resulting in a less significant wrinkle improvement effect (a wrinkle area reduction of 9% after 2W application and a wrinkle area reduction of 14% after 4W application).

The lack of ergothioneine in comparative example 2 reduced the skin's ability to combat free radicals, resulting in an increased rate of collagen degradation, but the data showed that this factor did not affect the trend of reduced wrinkle area (12% reduction in wrinkle area after 2W application; 20% reduction in wrinkle area after 4W application).

Comparative example 3, lacking Cynara scolymus leaf extract and palmitoyl tripeptide-5, compared to example 1, shows no significant wrinkle improvement (7% reduction in wrinkle area after 2W application; 10% reduction in wrinkle area after 4W application)

In summary, the nano anti-wrinkle essence cream provided by the embodiment of the application can improve skin conditions and wrinkles from multiple dimensions of moisturizing, enhancing skin barrier, resisting oxidation, reducing photodamage, increasing collagen synthesis and the like.

The above description is only an example of the present application and is not intended to limit the scope of the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A nanometer anti-wrinkle essence cream is characterized in that: the preparation raw materials comprise the following components in percentage by weight:

2. the nano anti-wrinkle essence cream according to claim 1, characterized in that: the anti-wrinkle essence milk further comprises the following components in percentage by weight: 0.0001 to 0.1 percent of ergothioneine.

3. The nano anti-wrinkle essence cream according to claim 2, characterized in that: the anti-wrinkle essence milk further comprises the following components in percentage by weight: 0.001-0.1% of artichoke leaf extract.

4. The nano anti-wrinkle essence cream according to claim 3, wherein: the anti-wrinkle essence milk further comprises the following components in percentage by weight: palmitoyl tripeptide-50.0001% -0.1%.

5. The nano anti-wrinkle essence cream according to claim 4, wherein: the emulsifier is one or two of PEG-20 methyl glucose sesquistearate, sunflower seed oil glyceride, caprylyl glycine and potassium lauroyl wheat amino acid.

6. The nano anti-wrinkle essence cream according to claim 5, wherein: the oil emollient is one or more of white chinlon oil, isononyl isononanoate, dioctyl carbonate, cetostearyl alcohol and cyclopentadimethylsiloxane.

7. The nano anti-wrinkle essence cream according to claim 6, wherein: the anti-wrinkle essence milk further comprises the following components in percentage by weight: 0.5 to 2 percent of preservative.

8. The nano anti-wrinkle essence cream according to claim 7, wherein: the preservative is a mixture of phenoxyethanol, 1, 2 hexanediol and caprylyl hydroximic acid.

9. The preparation method of the nano anti-wrinkle essence cream according to any one of claims 1 to 8, which is characterized by comprising the following steps:

10. The preparation method of the nano anti-wrinkle essence cream according to claim 9, wherein the nano anti-wrinkle essence cream comprises the following steps: in S3, the oil emollient is first heated, mixed and dissolved at 40-60 deg.c to dissolve the internal solute and form a homogeneously dissolved dispersed phase oil phase, and then the homogeneously dissolved dispersed phase oil phase is added to the mixed aqueous phase.