CN113876642B - A facial cream composition containing lipid nanoparticle with moisturizing effect and its preparation method - Google Patents
A facial cream composition containing lipid nanoparticle with moisturizing effect and its preparation method Download PDFInfo
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- CN113876642B CN113876642B CN202111339288.1A CN202111339288A CN113876642B CN 113876642 B CN113876642 B CN 113876642B CN 202111339288 A CN202111339288 A CN 202111339288A CN 113876642 B CN113876642 B CN 113876642B
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- cream composition
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a facial cream composition containing lipid nanoparticles with moisturizing effect and a preparation method thereof. The face cream comprises the following raw material components: 0.5-13.2 parts of lipid nanoparticle with moisturizing effect, 1-14.5 parts of emollient, 1-12.4 parts of emulsifier, 0.85-11.5 parts of filler, 1-23.8 parts of thickener, 0.1-3.2 parts of preservative, 0.01-2.6 parts of EDTA-2NA, 0.048-2.4 parts of pH regulator, 0.075-1.2 parts of daily essence and the balance of deionized water. The lipid nanoparticle with the moisturizing effect comprises the following main components: nidus Collocaliae acid, capsosiphon longifolia extract, and nicotinamide. The cream composition has the beneficial effects that the selected functional components have synergistic skin moisturizing effect through reasonable proportion, and the main functional components are wrapped by the lipid nanoparticles, so that transdermal delivery of the effective components is promoted, the rapid loss of the functional components is slowed down, the effective components can be slowly delivered locally on the skin, and the moisturizing effect for a long time is achieved.
Description
Technical Field
The invention relates to a skin care product and a preparation method thereof, belongs to the technical field of daily chemicals, and in particular relates to a cream composition containing lipid nanoparticles with moisturizing and moisturizing effects and a preparation method thereof.
Background
Moisturizing is always the most basic step of skin care, and the whole face can be healthy and full only if the cells of the skin drink enough water. When the skin water loss is too fast, the skin aging is easy to accelerate, the problems of wrinkles, desquamation and the like are caused, and people feel tired and have no spirit.
Factors causing skin water deficiency mainly comprise two aspects, namely, environmental factors bring about skin water deficiency, such as autumn and winter season, dry weather, rapid evaporation of moisture in the stratum corneum and large amount of moisture in the skin taken away by dry wind. In addition, metabolism of human bodies is slowed down in autumn and winter weather, blood flow speed is slowed down, grease secreted by sebaceous glands is reduced, water supplement of skin is slowed down, and the water locking capacity of skin is weakened due to insufficient supplement of sebum films, so that the problem of dryness of skin is caused.
In addition, the normal functions of the skin caused by the factors of the skin are damaged, such as natural aging of the skin, damage of skin metabolism caused by excessive cleaning and exfoliating, damage of the moisturizing system of the skin, rapid loss of the cell interstitium and natural moisturizing factors, difficulty in locking moisture of the skin, and long-term dryness and water shortage of the skin are caused.
How to carry out high-efficient moisturizing to skin is the field of long-term exploration in the industry, except scientific compound reasonable functional components, the purposes of moisturizing and moisturizing can be achieved only by considering that a moisturizing system of the skin needs to be repaired except for instant moisturizing of the skin and enhancing the moisturizing capability of the skin, so that the functional components can be effectively delivered to a target part for acting through skin, and the method is one aspect which needs to be noted in cosmetic preparation.
Disclosure of Invention
The present invention aims to provide a cream composition comprising lipid nanoparticles having moisturizing effect, which can serve to supplement moisture to skin, repair the moisturizing system of skin, and increase the moisture content of skin horny layer, which would be greatly appreciated by consumers.
Another object of the present invention is to provide a method for preparing the above-mentioned cream composition comprising lipid nanoparticles having moisturizing effect.
In order to achieve the above object, the present invention adopts the following technical scheme:
a cream composition comprising lipid nanoparticles with moisturizing efficacy, which comprises the following components in parts by weight:
0.5-12 parts of lipid nanoparticle with moisturizing effect, which comprises the following components: 0.1-2.5 parts of cubilose acid, 0.1-4.5 parts of kappaphycus alvarezii extract and 0.1-5 parts of nicotinamide;
88-99.5 parts of cosmetic auxiliary material matrix, which comprises: 1 to 14.5 parts of emollient, 1 to 12.4 parts of emulsifier, 0.85 to 11.5 parts of filler, 1 to 23.8 parts of thickener, 0.1 to 3.2 parts of preservative, 0.01 to 2.6 parts of EDTA-2NA, 0.048 to 2.4 parts of pH regulator, 0.075 to 1.2 parts of daily essence and the balance of deionized water.
Preferably, the cream composition containing lipid nanoparticles with moisturizing effect comprises the following components in parts by weight:
0.5-9 parts of lipid nanoparticle with moisturizing effect, which comprises the following components: 0.1-2 parts of cubilose acid, 0.1-4 parts of kappaphycus alvarezii extract and 0.1-3 parts of nicotinamide;
91-99.5 parts of cosmetic auxiliary material matrix, which comprises: 5-12 parts of an emollient, 2-10 parts of an emulsifier, 1-8 parts of a filler, 2-15 parts of a thickener, 0.5-1.2 parts of a preservative, 0.1-1.8 parts of EDTA-2NA, 0.05-1.2 parts of a pH regulator, 0.08-0.8 part of a daily essence and the balance of deionized water.
Preferably, the cream composition containing lipid nanoparticles with moisturizing effect comprises the following components in parts by weight:
a lipid nanoparticle having moisturizing efficacy comprising: 0.1-1 part of cubilose acid, 0.1-2 parts of kappaphycus alvarezii extract and 0.1-2 parts of nicotinamide;
a cosmetic adjuvant matrix comprising: 5-10 parts of an emollient, 3-7 parts of an emulsifier, 1.5-2 parts of a filler, 5-10 parts of a thickener, 0.8-1.2 parts of a preservative, 0.8-1.2 parts of EDTA-2NA, 0.5-1.2 parts of a pH regulator, 0.1-0.3 parts of a daily essence and the balance of deionized water.
Preferably, the lipid nanoparticle with moisturizing effect comprises the following main components in percentage by mass: cubilose acid: extract of kappaphycus alvarezii: nicotinamide = 1: (2-4.5): (1.5-3).
Preferably, the lipid nanoparticle with moisturizing effect comprises the following main components in percentage by mass: cubilose acid: myrrh leaf cell extract: oculopathy nannochloropsis = 1: (1-2.5): (1-3).
Preferably, the lipid nanoparticle with moisturizing effect comprises the following steps:
1) Proper amount of moisturizing and moisturizing efficacy components: dissolving nidus Collocaliae acid, capsosiphon longifolia extract and nicotinamide in deionized water to form an inner water phase (W1);
2) Dissolving a certain amount of solid lipid capsule wall material and lipophilic emulsifier in an organic solvent to form an oil phase;
3) The internal aqueous phase was taken up in 1: adding the volume ratio of (2-6) into the oil phase solution, and performing ultrasonic treatment for 2-10 min under the ice bath condition with the power of 60-80W by using a cell pulverizer to obtain W1/O type emulsion;
4) The W1/O type emulsion obtained in the step 3) is mixed with the following components in a volume ratio of 1: (10-30) adding the mixture into a PVA aqueous solution containing 0.2-2%, and carrying out ultrasonic treatment for 2-10 min at a power of 60-80W by using a cell pulverizer under the ice bath condition to obtain W1/O/W2 type emulsion;
5) Stirring the W1/O/W2 emulsion obtained in the step 4) for 1-4 hours at room temperature to completely volatilize the organic solvent so as to obtain a suspension of lipid nanoparticles; centrifuging at 8000-12000r/min for 10-30min at 4deg.C, removing supernatant, washing with deionized water for 3 times, lyophilizing for 24 hr, and storing in 4deg.C refrigerator.
Specifically, the solid lipid vesicles are selected from the group consisting of: one or more of glyceryl tristearate, cetyl palmitate, steroid, triglyceride, palmitic acid and stearic acid;
the lipophilic emulsifier is one or more selected from span 20, span 60 and span 80;
the organic solvent is selected from one or more of dichloromethane, acetone, chloroform and hexane;
the particle size of the lipid nanoparticle is 0.1-0.5 μm.
Preferably, the emollient is selected from one or more of glycerol, squalane, panthenol, isohexadecane, butanediol, wheat germ oil, octylglycol, hydrogenated polyisobutene, tocopheryl acetate, propylene glycol, capric triglyceride, mannose, phytosterol, xylitol, sodium hyaluronate, octyl polymethylsiloxane, jojoba oil, hexylene glycol, cyclohexasiloxane, glyceryl caprylate, polyethylene glycol, dipropylene glycol.
The emulsifier is one or more selected from PEG-100 stearate, isocetyl polyether-20, glyceryl polyether-26, polysorbate 20, PEG-20 methyl glucose sesquistearate and polysorbate 80;
the filler is one or more selected from titanium dioxide, tapioca starch, kaolin, sodium chloride, silica and magnesium sulfate;
the thickener is one or more selected from acrylamide/VP copolymer, acrylic acid (ester) C10-30 alkanol acrylate cross-linked polymer, polyacryl dimethyl taurate amine, carbomer, sodium polyacrylate, hydroxyethyl cellulose, polyacrylate cross-linked polymer-6, guar gum, C12-20 alkyl glucoside alginic acid and xanthan gum;
the preservative is one or more selected from phenoxyethanol, chlorpheniramine, butanediol and methylparaben;
the pH regulator selects one or more of arginine or lactic acid.
Further, the preparation method of the cream composition containing the lipid nanoparticle with moisturizing effect comprises the following steps:
1) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
2) Adding an emollient, a filler, a preservative and EDTA-2NA into the mixed solution in the step 1), heating to 70-80 ℃, homogenizing for 5-10 minutes at 2000-4000r/min to ensure that the mixed solution is completely dispersed;
3) Adding emulsifying agent, daily essence and pH regulator into the step 2), homogenizing for 5-10 min at 2000-4000r/min to completely emulsify, stirring and cooling, and adding lipid nanoparticle with moisturizing effect to obtain facial cream composition containing lipid nanoparticle with moisturizing effect.
Preferably, the cream composition is in the form of solvent dispersion or suspension, or in the form of emulsified particles, or in the form of a polymer coating.
In particular, the cream composition has a pH in the range of 4-10, preferably a pH in the range of 5-8, most preferably a pH in the range of 5-7.
By means of the technical scheme, the invention has the following beneficial effects:
1) The main functional components of the lipid nanoparticle with moisturizing and hydrating effects comprise: nidus Collocaliae acid, capsosiphon longifolia extract, and nicotinamide. Wherein, the bird's nest acid can promote the synthesis of extracellular hyaluronic acid, and enhance the water retention capacity of the skin; the Kappaphycus alvarezii extract can relieve xerosis cutis and supplement water content of running water; the nicotinamide has the effects of enhancing skin metabolism, repairing skin barrier and preventing skin moisture loss.
2) The three functional components of the invention can promote the synthesis of extracellular hyaluronic acid, enhance the water retention capacity of skin, relieve skin dryness, supplement water of running water, enhance skin metabolism and repair skin barrier, and simultaneously, the three components are compounded for use to have synergistic long-term moisturizing effect.
3) The lipid nanoparticle with the moisturizing effect is innovative, and the lipid nanoparticle wraps the main effective components, so that transdermal delivery of the effective components is promoted, and rapid loss of the effective components is slowed down, so that the effective components can be slowly delivered locally on the skin, and the moisturizing effect for a long time is achieved.
Drawings
FIG. 1 is a graph showing efficacy test of moisturizing liposomes in example 1;
FIG. 2 is a graph showing the change in moisture content of the stratum corneum of the skin over 56 days after using the cream and base cream of example 1;
FIG. 3 is a graph showing the change in moisture content of the stratum corneum after using example 1 and comparative examples 1 to 7.
Detailed Description
The invention discloses a cream composition containing lipid nanoparticles with moisturizing effect. The main functional components of the face cream composition comprise: nidus Collocaliae acid, capsosiphon longifolia extract, and nicotinamide. It has effects in supplementing water and promoting repair of skin moisturizing system. The present invention finds the best choice through the preferred combination and efficacy test. All the raw material components described below are commercially available products unless otherwise specified.
(1) Cubilose acid
Sialic acid, known as nidus Collocaliae acid, is widely distributed in human tissues, exists in the form of cell membrane glycoprotein and glycolipid, has various different biological functions, and plays a very important role in regulating physiological and biochemical functions of human bodies. In the aspect of skin care, the bird's nest acid has remarkable anti-aging and freckle-removing functions, can promote synthesis and secretion of macromolecules such as extracellular hyaluronic acid, glycoprotein and the like, enhances the hydrophilicity of skin, maintains the moisture in dermis, can also enhance the water-retaining capacity of epidermis horny layer, and is flexible and transparent to skin.
(2) Capparis longa extract
The Kappaphycus alvarezii has upright, clustered and cylindrical algae bodies, grows under the condition of normal and sufficient nutrition, and is purple-red kelp. The Kappaphycus alvarezii extract can improve the structural integrity of horny layer and the biosynthesis function of epidermis of dry skin to reduce skin water loss, can provide sufficient water and nutrient minerals for skin in 24 hours, is helpful for maintaining the water level of skin and regulating the dynamic balance of skin, and makes skin smoother and healthier.
(3) Nicotinamide
Besides enhancing metabolism of skin, the nicotinamide can improve the levels of free fatty acid and ceramide in the skin at a certain concentration, supplement intercellular lipid, repair skin barrier and fundamentally enhance the moisturizing ability of the skin.
Examples 1 to 3
A facial cream composition containing lipid nanoparticles with moisturizing effect comprises the following raw materials in proportion and content shown in table 1.
TABLE 1 raw material composition ratios (unit: parts by mass) of examples 1 to 3
The preparation process of the cream containing lipid nanoparticles with moisturizing effect of the above embodiment 1 includes the following steps:
1) Dissolving 70mg of cubilose acid, 140mg of kappaphycus alvarezii extract and 140mg of nicotinamide in 5mL of deionized water to form an inner water phase (W1); 500mg of glyceryl tristearate and span 80 were dissolved in 15mL of methylene chloride to form an oil phase; the internal aqueous phase was taken up in 1:3, adding the mixture into the oil phase solution in a volume ratio, and performing ultrasonic treatment for 3min at a power of 60W by using a cell pulverizer under the ice bath condition to obtain W1/O type emulsion;
the W1/O emulsion obtained was mixed in a volume ratio of 1:10 is added into PVA water solution containing 0.5 percent, and under the ice bath condition, the cell grinder is used for ultrasonic treatment for 3 minutes with the power of 60W to obtain W1/O/W2 type emulsion;
stirring the W1/O/W2 emulsion obtained in the step at room temperature for 1.5h to completely volatilize the organic solvent so as to obtain a suspension of lipid nanoparticles; centrifuging at a rotation speed of 8000r/min at 4deg.C for 10min, removing supernatant, washing with deionized water for 3 times to precipitate, freeze drying for 24 hr, and storing in a refrigerator at 4deg.C for use, wherein the lipid nanoparticle has a particle diameter of 0.16+ -0.02 μm;
2) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
3) Adding an emollient, a filler, a preservative and EDTA-2NA into the mixed solution in the step 2), heating to 70 ℃, homogenizing for 5 minutes at 2800r/min to ensure that the mixed solution is completely dispersed;
4) Adding an emulsifying agent, daily essence and a pH regulator into the step 3), homogenizing for 5 minutes at 2800r/min to enable the emulsifying agent to be completely emulsified, and adding lipid nanoparticles when stirring and cooling to obtain a cream composition containing the lipid nanoparticles with moisturizing and moisturizing effects, wherein the pH is 5.8.
The preparation process of the cream containing lipid nanoparticles with moisturizing effect of the above embodiment 2 includes the following steps:
1) 165mg of cubilose acid, 330mg of kappaphycus alvarezii extract and 330mg of nicotinamide are dissolved in 10mL of deionized water to form an inner water phase (W1);
1000mg of cetyl palmitate and span 60 were dissolved in 50mL of hexane to form an oil phase; the internal aqueous phase was taken up in 1:5, adding the mixture into the oil phase solution in a volume ratio, and performing ultrasonic treatment for 5min with a cell pulverizer under the ice bath condition at a power of 70W to obtain W1/O type emulsion;
the W1/O emulsion obtained was mixed in a volume ratio of 1:12 is added into PVA water solution containing 0.2 percent, and under the ice bath condition, the cell grinder is used for ultrasonic treatment for 5 minutes with the power of 70W to obtain W1/O/W2 type emulsion; stirring the W1/O/W2 emulsion obtained in the step at room temperature for 2 hours to completely volatilize the organic solvent so as to obtain a suspension of lipid nanoparticles;
and centrifuging at 4deg.C at 10000r/min for 15min, removing supernatant, washing with deionized water for 3 times, lyophilizing for 24 hr, and storing in 4deg.C refrigerator to obtain lipid nanoparticle with particle diameter of 0.20+ -0.03 μm.
2) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
3) Adding an emollient, a filler, a preservative and EDTA-2NA into the mixed solution in the step 2), heating to 75 ℃, homogenizing for 8 minutes at 3000r/min to ensure that the mixed solution is completely dispersed;
4) Adding an emulsifying agent, daily essence and a pH regulator into the step 3), homogenizing for 8 minutes at 3000r/min to enable the emulsifying agent to be completely emulsified, and adding lipid nanoparticles when stirring and cooling to obtain the cream composition containing the lipid nanoparticles with the moisturizing and moisturizing effects, wherein the pH is 5.6.
The preparation process of the cream containing lipid nanoparticles with moisturizing effect of the above embodiment 3 includes the following steps:
1) Dissolving 400mg of cubilose acid, 800mg of kappaphycus alvarezii extract and 800mg of nicotinamide in 12mL of deionized water to form an inner water phase (W1);
200mg of palmitic acid and span 20 were dissolved in 48mL of chloroform to form an oil phase; the internal aqueous phase was taken up in 1:4, adding the mixture into the oil phase solution in a volume ratio, and performing ultrasonic treatment for 5min at a power of 80W by using a cell pulverizer under the ice bath condition to obtain W1/O type emulsion;
the W1/O emulsion obtained was mixed in a volume ratio of 1:12 is added into PVA water solution containing 0.5 percent, and under the ice bath condition, the cell grinder is used for ultrasonic treatment for 5 minutes with the power of 70W to obtain W1/O/W2 type emulsion; stirring the W1/O/W2 emulsion obtained in the step for 4 hours at room temperature to completely volatilize the organic solvent so as to obtain a suspension of lipid nanoparticles;
and centrifuging at 12000r/min for 30min at 4deg.C, removing supernatant, washing with deionized water for 3 times, lyophilizing for 24 hr, and storing in a refrigerator at 4deg.C for use to obtain lipid nanoparticle with particle diameter of 0.14+ -0.01 μm.
2) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
3) Adding an emollient, a filler, a preservative and EDTA-2NA into the mixed solution in the step 2), heating to 80 ℃, homogenizing for 10 minutes at 3500r/min to ensure that the mixed solution is completely dispersed;
4) Adding an emulsifying agent, daily essence and a pH regulator into the step 3), homogenizing at 3500r/min for 10min to enable the emulsifying agent to be completely emulsified, adding lipid nanoparticles when stirring and cooling to obtain a cream composition containing lipid nanoparticles with moisturizing and moisturizing effects, wherein the pH is 5.5.
Effect verification test example
1. Safety test
Test sample: example 1;
the testing method comprises the following steps: and testing the security by adopting a third party detection mechanism. The selected area is not more than 50mm 2 A suitable patch device having a depth of about 1mm is provided by adding about 0.02 to about 0.025ml (g) of a subject to the patch device by a closed patch test method.
The patch tester is attached to the forearm of a subject, the test object is removed after 24 hours, skin reactions are observed after 0.5 hour, 24 hours and 48 hours respectively, and the results are recorded according to the skin reaction grading standard in cosmetic safety technical regulations 2015.
TABLE 2 Patch test results
Remarks: skin response grading criteria;
level 0: a negative reaction;
stage 1: suspicious reactions; only weak erythema;
2 stages: weak positive response (erythema response); erythema, infiltration, edema, and possibly papules;
3 stages: strong positive response (herpes response); erythema, infiltration, edema, papules, herpes; the reaction may be beyond the test zone;
4 stages: extremely strong reactions (fusogenic herpetic reactions); obvious erythema, severe infiltration, edema, blepharospermia, and response beyond the test area.
From table 2 above, the prepared cream showed no irritation and was safe.
2. Stability test
Test sample: example 1;
the testing method comprises the following steps: internal control standard, the appearance color, viscosity, pH for three months was observed.
TABLE 3 stability investigation results
| Time | 45℃ | 40℃ | 37℃ | 25℃ | 5℃ | -15℃ | CYCLE | Illumination of |
| 1W | √ | √ | √ | √ | √ | √ | √ | √ |
| 2W | √ | √ | √ | √ | √ | √ | √ | √ |
| 3W | √ | √ | √ | √ | √ | √ | √ | √ |
| 4W | √ | √ | √ | √ | √ | √ | √ | √ |
| 2M | √ | √ | √ | √ | √ | √ | √ | √ |
| 3M | √ | √ | √ | √ | √ | √ | √ | √ |
As shown in the table 3, the prepared face cream has no obvious change in color, viscosity and pH within three months under the conditions of high and low temperature or illumination, which proves that the face cream has better stability.
3. Efficacy test of moisturizing liposomes
Test sample: lipid nanoparticles with moisturizing efficacy in example 1; the control group was a mixture of glycerin and water.
The testing method comprises the following steps: the lipid nanoparticle with moisturizing and moisturizing effects, glycerol and water are compounded and then smeared in the left hand or right hand forearm of a subject for measurement, and a skin moisture meter is used for measuring the moisture content of the skin cuticle at regular intervals.
Test results: as shown in fig. 1, the water replenishing effect of the experimental group reached 13% far higher than that of the control group within 24 hours. The moisturizing effect of the experimental group is maintained between 27 and 31 percent in the first 6 hours, which shows that the lipid nanoparticle with moisturizing effect can play a role in instant moisturizing, can maintain the moisture of the skin in a normal range in 24 hours, and can effectively solve the problems of dry skin and the like.
4. Evaluation of moisturizing Effect
Test sample: example 1 (experimental group) and basic moisturizing cream (control group: cream composition without liposome encapsulation, other ingredients content same as experimental group);
the testing method comprises the following steps: the test method comprises the steps that after the face of a subject is cleaned every day, the face of the subject is smeared on the cheek on the same side, and no product is used in the test day; the test is performed in a room at 20-22 c with a relative humidity of 40-60% and the subject must now be conditioned for 15 minutes in the same environment.
The results were tested in the following 4 time periods, respectively: before the sample (D0), after 14 days of the sample (D14), after 28 days of the sample (D28), and after 56 days of the sample (D56).
The detection items are as follows:
corneometer CM825 detects changes in stratum corneum moisture content;
test results:
as shown in fig. 2 and table 4, the clinical efficacy test experiment results of the face cream containing the liposome with moisturizing efficacy show that the moisture content of the horny layer of the cheek part of the subject is tested within 56 days of using the sample, and the moisture content of the horny layer of the skin of the experimental group is improved from 52.1% to 74.6% after 56 days of using the sample; the control group is improved by 64.0% from 52.3%, which shows that the prepared facial cream has better effect of protecting the moisture content of the skin cuticle compared with the common basic moisturizing facial cream.
TABLE 4 moisture content of stratum corneum (%)
5. Synergistic experiments of face cream composition
A facial cream composition with moisturizing effect comprises the following raw materials in proportion in comparative example, as shown in Table 5.
Table 5 comparative examples 1 to 7 face cream composition ratio Table (unit: parts by mass) having moisturizing effect
The preparation process of the face cream with the moisturizing and moisturizing effects comprises the following steps of:
1) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
2) Adding the moisturizing and moisturizing functional components, the emollient, the filler, the preservative and the EDTA-2NA into the mixed solution in the step 1), heating to 70 ℃, homogenizing for 5 minutes at 2800r/min to ensure that the components are completely dispersed;
3) Adding the emulsifying agent, the daily essence and the pH regulator into the step 2), homogenizing for 5 minutes at 2800r/min to completely emulsify, stirring and cooling to obtain the face cream composition with the moisturizing and moisturizing effects.
The effects of examples and comparative examples 1 to 7 in the moisturizing and moisturizing synergy experiments were verified, and the experimental steps and results are as follows:
1. the tester: 80 healthy females (25-45 years old) are divided into 8 groups of 10 individuals each; the same formulation was used for each group.
2. Test area: a face;
3. the method comprises the following steps: the test method comprises the steps that after the face of a subject is cleaned every day, the face of the subject is smeared on the cheek on the same side, and no product is used in the test day; the test is performed in a room at 20-22 c with a relative humidity of 40-60% and the subject must now be conditioned for 15 minutes in the same environment.
4. Test instrument: corneometer CM825 for measuring stratum corneum moisture content
5. The test results are shown in table 6 below.
Table 6 test set effect
As can be seen from the results of table 6 and fig. 3, example 1 has the best moisturizing effect after 56 days of using the prepared cream, which is capable of increasing the moisture content of the skin horny layer to 74.6%, by 10.6% compared to comparative example 7 without using liposomes, while the moisturizing effect of comparative example 7 is increased by 4 to 7% compared to comparative example using only one or some two effective field components.
In conclusion, the selected functional components have synergistic moisturizing and moisturizing effects after being mixed according to the golden ratio, and the three functional components can promote the synthesis of extracellular hyaluronic acid, enhance the moisturizing capability of skin, relieve skin dryness, supplement water of running water, enhance metabolism of skin and repair skin barriers.
In addition, the lipid nanoparticles encapsulate the main effective components, so that the transdermal delivery of the effective components is promoted, the rapid loss of the effective components is slowed down, the effective components can be slowly delivered locally on the skin, and the long-time moisturizing and moisturizing effects are achieved.
The present invention is not limited to the preferred embodiments, but can be modified, equivalent, and modified in any way without departing from the technical scope of the present invention.
Claims (6)
1. A cream composition comprising lipid nanoparticles having moisturizing efficacy, characterized in that the cream composition is composed of, by weight, 100 parts: 0.5-9 parts of lipid nanoparticle with moisturizing effect, which comprises the following components: 0.1-2 parts of cubilose acid, 0.1-4 parts of kappaphycus alvarezii extract and 0.1-3 parts of nicotinamide;
91-99.5 parts of cosmetic auxiliary material matrix, which comprises: 5-12 parts of an emollient, 2-10 parts of an emulsifier, 1-8 parts of a filler, 2-15 parts of a thickener, 0.5-1.2 parts of a preservative, 0.1-1.8 parts of EDTA-2NA, 0.05-1.2 parts of a pH regulator, 0.08-0.8 part of a daily essence and the balance of deionized water;
the lipid nanoparticle with the moisturizing effect comprises the following main components in percentage by mass: cubilose acid: extract of kappaphycus alvarezii: nicotinamide = 1: (2-4.5): (1.5-3); the bird's nest acid, the kappaphycus alvarezii extract and the nicotinamide which are main effective components are wrapped by the lipid nanoparticles, so that transdermal delivery of the effective components is promoted, and loss of the effective components is slowed down;
the lipid nanoparticle with the moisturizing effect is prepared by the following steps:
1) Proper amount of moisturizing and moisturizing efficacy components: dissolving nidus Collocaliae acid, capsosiphon longifolia extract and nicotinamide in deionized water to form an inner water phase W1;
2) Dissolving a certain amount of solid lipid capsule wall material and lipophilic emulsifier in an organic solvent to form an oil phase;
3) The internal aqueous phase was taken up in 1: adding the volume ratio of (2-6) into the oil phase solution, and performing ultrasonic treatment for 2-10 min under the ice bath condition with the power of 60-80W by using a cell pulverizer to obtain W1/O type emulsion;
4) The W1/O type emulsion obtained in the step 3) is mixed with the following components in a volume ratio of 1: (10-30) adding the mixture into a PVA aqueous solution containing 0.2-2%, and carrying out ultrasonic treatment for 2-10 min at a power of 60-80W by using a cell pulverizer under the ice bath condition to obtain W1/O/W2 type emulsion;
5) Stirring the W1/O/W2 emulsion obtained in the step 4) for 1-4 hours at room temperature to completely volatilize the organic solvent so as to obtain a suspension of lipid nanoparticles; centrifuging at 8000-12000r/min for 10-30min at 4deg.C, removing supernatant, washing with deionized water for 3 times, lyophilizing for 24 hr, and storing in 4deg.C refrigerator;
the solid lipid capsule material is one or more selected from glyceryl tristearate, cetyl palmitate, steroid, triglyceride, palmitic acid and stearic acid;
the lipophilic emulsifier is one or more selected from span 20, span 60 and span 80;
the organic solvent is selected from one or more of dichloromethane, acetone, chloroform and hexane;
the particle size of the lipid nanoparticle is 0.1-0.5 mu m;
the emollient is selected from one or more of glycerol, squalane, panthenol, isohexadecane, butanediol, wheat germ oil, octaethylene glycol, hydrogenated polyisobutene, tocopheryl acetate, propylene glycol, capric triglyceride, mannose, phytosterol, xylitol, sodium hyaluronate, octyl polymethylsiloxane, jojoba oil, hexylene glycol, cyclohexasiloxane, glycerol caprylate, polyethylene glycol, dipropylene glycol;
the emulsifier is one or more selected from PEG-100 stearate, isocetyl polyether-20, glyceryl polyether-26, polysorbate 20, PEG-20 methyl glucose sesquistearate and polysorbate 80;
the filler is one or more selected from titanium dioxide, tapioca starch, kaolin, sodium chloride, silica and magnesium sulfate;
the thickener is one or more selected from acrylamide/VP copolymer, acrylic acid (ester) C10-30 alkanol acrylate cross-linked polymer, polyacryl dimethyl taurate amine, carbomer, sodium polyacrylate, hydroxyethyl cellulose, polyacrylate cross-linked polymer-6, guar gum, C12-20 alkyl glucoside alginic acid and xanthan gum;
the preservative is one or more selected from phenoxyethanol, chlorpheniramine, butanediol and methylparaben;
the pH regulator selects one or more of arginine or lactic acid.
2. A method for preparing a cream composition comprising lipid nanoparticles having moisturizing effect as claimed in claim 1, comprising the steps of:
1) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
2) Adding an emollient, a filler, a preservative and EDTA-2NA into the mixed solution in the step 1), heating to 70-80 ℃, homogenizing for 5-10 minutes at 2000-4000r/min to ensure that the mixed solution is completely dispersed;
3) Adding emulsifying agent, daily essence and pH regulator into the step 2), homogenizing for 5-10 min at 2000-4000r/min to completely emulsify, stirring and cooling, and adding lipid nanoparticle with moisturizing effect to obtain facial cream composition containing lipid nanoparticle with moisturizing effect.
3. The method of manufacturing as claimed in claim 2, wherein: the cream composition is in the form of solvent dispersion or suspension, or in the form of emulsified particles, or in the form of a polymer coating.
4. A method of preparation as claimed in claim 3, wherein: the cream composition has a pH of 4-10.
5. The method of manufacturing according to claim 4, wherein: the cream composition has a pH of 5-8.
6. The method of manufacturing according to claim 5, wherein: the cream composition has a pH of 5-7.
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