CN113893203B

CN113893203B - Facial cream composition containing anti-aging efficacy liposome and preparation method and application thereof

Info

Publication number: CN113893203B
Application number: CN202111396415.1A
Authority: CN
Inventors: 李宗厚; 杨帆; 周紫燕; 李沫; 郭苗; 周正
Original assignee: Hubei Maishite Biotechnology Co Ltd
Current assignee: Hubei Maishite Biotechnology Co Ltd
Priority date: 2021-11-23
Filing date: 2021-11-23
Publication date: 2023-06-20
Anticipated expiration: 2041-11-23
Also published as: CN113893203A

Abstract

The invention discloses a face cream composition containing anti-aging efficacy liposome and a preparation method thereof. The cream composition comprises the following raw material components: 0.1-15% of anti-aging efficacy liposome, 1-30% of humectant, 1-22.5% of emollient, 1-21% of emulsifier, 0.1-10% of filler, 1-12.5% of thickener, 0.1-3.5% of preservative, 0.01-1% of pH regulator, 0.01-1% of daily essence and the balance of deionized water. The main components of the anti-aging efficacy liposome comprise: hexapeptide-11, dunaliella salina extract, leucasian willow leaf extract, gynostemma pentaphyllum extract. The invention can increase the synthesis of skin collagen, enhance the activity of superoxide dismutase, remove excessive free radicals in skin, reduce peroxidation damage of tissues or cells, strengthen skin barrier, strengthen skin structure and resist skin aging relaxation through simultaneous compounding of the components.

Description

Facial cream composition containing anti-aging efficacy liposome and preparation method and application thereof

Technical Field

The invention relates to a skin care product and a preparation method and application thereof, belongs to the technical field of daily chemicals, and in particular relates to a facial cream composition containing anti-aging efficacy liposome and a preparation method and application thereof.

Background

Today, anti-aging has become the most interesting point in the skin care process, and the earlier skin care is started, the longer the skin state can be maintained. Generally, people can feel the gradual aging of skin at the age of 25 years, skin injury caused by skin aging is difficult to restore to the original state, and skin relaxation, fine lines around eyes, dark complexion and the like caused by aging can be effectively improved only by protecting the skin in advance and delaying the arrival of the aging.

In addition to the gradual aging of skin, there are some external factors that accelerate the aging, such as external ultraviolet radiation, ultraviolet rays can invade the dermis of a person, increase free radicals in the skin, damage skin tissues and various cell structures, and simultaneously, collagen fibers and elastic fibers of the dermis layer are damaged, and the skin is loosened and wrinkled. In addition, the life of the skin is irregular in normal times, and the skin is disturbed due to insufficient sleep, so that the skin is aged rapidly, loose and drooping due to loss of elasticity; meanwhile, when the pressure is increased every day, the tissues of the human skin are destroyed and decomposed, and the barrier function of the skin is lowered.

Although we can reduce skin aging caused by external factors through some protection means, it still causes more or less damage to human skin. Skin aging is caused by both endogenous and various exogenous factors, and it is very difficult to restore the skin state, but we can delay or improve aging caused by external factors by using some skin care products.

How to formulate effective anti-aging compositions is an important matter of constant research in the cosmetic industry.

Disclosure of Invention

The invention aims to provide a facial cream composition containing anti-aging liposome, which can play an anti-aging skin tightening role and is greatly favored by consumers.

The invention also aims to provide a preparation method of the facial cream composition containing the anti-aging efficacy liposome, wherein the liposome wraps the selected efficacy components, so that the transdermal delivery efficiency of the efficacy components is enhanced, the residence time of the efficacy components in the skin is prolonged, the efficacy components can be slowly released, and the utilization rate of the efficacy components is increased.

It is another object of the present invention to provide the use of the above-described cream composition comprising anti-aging efficacy liposomes.

In order to achieve the above object, the present invention adopts the following technical scheme:

a cream composition comprising anti-aging efficacy liposomes, the cream composition comprising, based on the total weight of the composition:

0.1-15% of liposome with anti-aging effect, which comprises the following main components: 0.1-2% hexapeptide-11, 0.1-5% Dunaliella salina extract, 0.1-3% Leisha fuzifolia extract, 0.1-4% Gynostemma Pentaphyllum extract;

85-99.9% of cosmetic auxiliary material matrix.

Preferably, the cream composition containing the anti-aging efficacy liposome comprises the following components in percentage by weight:

1 to 30 percent of humectant, 1 to 22.5 percent of emollient, 1 to 21 percent of emulsifier, 0.1 to 10 percent of filler, 1 to 12.5 percent of thickener, 0.1 to 3.5 percent of preservative, 0.01 to 1 percent of pH regulator, 0.01 to 1 percent of daily essence and the balance of deionized water.

1-12% of anti-aging efficacy liposome, which mainly comprises the following components: 0.1-1% hexapeptide-11, 0.1-3% Dunaliella salina extract, 0.1-2% Leisha fuzifolia extract, 0.1-2% Gynostemma Pentaphyllum extract;

88-99% of cosmetic auxiliary material matrix, which consists of the following components: 5-20% of humectant, 1-12.5% of emollient, 1-11% of emulsifier, 0.1-8% of filler, 1-8.5% of thickener, 0.1-1.5% of preservative, 0.01-0.8% of pH regulator, 0.01-0.7% of daily essence and the balance of deionized water.

5-10% of anti-aging efficacy liposome, which mainly comprises the following components: 0.1-1% hexapeptide-11, 0.1-3% Dunaliella salina extract, 0.1-2% Leisha fuzifolia extract, 0.1-2% Gynostemma Pentaphyllum extract;

88-99% of cosmetic auxiliary material matrix, which consists of the following components: 6-10% of humectant, 3-5% of emollient, 3-5% of emulsifier, 1-5% of filler, 2-5% of thickener, 0.5-1.5% of preservative, 0.01-0.8% of pH regulator, 0.01-0.7% of daily essence and the balance of deionized water.

Preferably, the cream composition containing the anti-aging efficacy liposome comprises the following main components in percentage by mass based on the total weight of the composition:

hexapeptide-11, dunaliella salina extract, willow leaf extract, fiveleaf fleshy leaf extract = 1: (2-4): (1-3): (1-4.5).

Preferably, the cream composition containing the anti-aging efficacy liposome comprises the following steps:

1) Weighing a proper amount of hexapeptide-11, dunaliella salina extract, fulai willow leaf extract and gynostemma pentaphylla extract, and dissolving in phosphate buffer solution with pH=6.8 by ultrasonic;

2) Weighing a certain amount of phospholipid and cholesterol according to the mass ratio of (1-8): 1 dissolving in an appropriate amount of organic solvent by ultrasonic dissolution;

3) Pouring the phosphate buffer solution in the step 1) into the organic solvent in the step 2), homogenizing for 2-8 min at the speed of 10000-20000 r/min, and removing the organic solvent at room temperature;

4) Adding a certain amount of mannitol, performing ultrasonic treatment on the mixed solution obtained in the step 3) to obtain emulsion, filtering with a 0.45m filter membrane, and freeze-drying the filtrate with a freeze dryer for 12-48 h to obtain the anti-aging liposome coated with the functional components.

Preferably, the phospholipid is selected from one or more of lecithin, cephalin, dipalmitoyl phospholipid and hydrogenated soybean phospholipid; the organic solvent is selected from one or more of dichloromethane, diethyl ether, ethyl acetate, chloroform and acetone; the particle size of the liposome is 50-200nm.

Preferably, the cream composition comprising anti-aging efficacy liposomes, the moisturizer is selected from the group consisting of: one or more of glycerol, butanediol, sorbitol, xylitol, panthenol, trehalose, sodium hyaluronate, phytosterol fatty alcohols (such as cetyl alcohol, stearyl alcohol, and behenyl alcohol).

The emollient is selected from: oils/esters such as one or more of isohexadecane, isopropyl isostearate, caprylic/capric triglyceride, butter fruit, silicone oil;

the emulsifier is selected from: one or more of glycerol stearate, PEG-100 stearate, cetostearyl glucoside;

the filler is selected from: one or more of polymethylsilsesquioxane, silica powder, starch octyl aluminum succinate, talcum powder and volcanic ash;

the thickener is selected from: one or more of carbomer, xanthan gum, modified starch, sodium acrylate/sodium acryloyldimethyl taurate copolymer;

the preservative is selected from the group consisting of: one or more of phenoxyethanol, ethylhexyl glycerol and pentanediol;

the pH regulator is one or more of lactic acid, arginine and sodium hydroxide.

Preferably, the preparation method of the cream composition containing the anti-aging efficacy liposome comprises the following steps:

1) Firstly, dissolving a thickening agent with deionized water, and uniformly stirring and dispersing;

2) Adding the humectant into the mixed solution in the step 1), stirring, heating to 70-80 ℃, and preserving heat and stirring for 10-30 minutes to obtain a water phase material;

3) Dissolving an emollient and an emulsifier with deionized water, stirring and dispersing uniformly, and heating to 70-80 ℃ until the emollient and the emulsifier are completely dissolved to obtain an oil phase material;

4) Slowly adding the oil phase material into the water phase material in a homogeneous state of 3000-5000r/min, continuously homogenizing for 5-15min, and then adding the pH regulator, the filler and the preservative;

5) Stirring and cooling the mixed solution in the step 4) to 40-50 ℃, adding anti-aging liposome and daily essence, and homogenizing for 5-10min at 1500-3000 r/min;

6) After homogenization, stirring and cooling to 30-40 ℃ at the speed of 200-300r/min to obtain the facial cream composition containing the anti-aging liposome.

Specifically, a cosmetic comprises a face cream composition having anti-aging efficacy liposomes; the cosmetic is in the form of solvent dispersion or suspension, or in the form of emulsified particles, or in the form of polymer packages.

By means of the technical scheme, the invention has the following beneficial effects:

1) The innovative anti-aging functional components of the invention mainly comprise: hexapeptide-11, dunaliella salina extract, leucasian willow leaf extract, and Gynostemma Pentaphyllum extract can increase skin collagen synthesis, enhance superoxide dismutase activity, remove excessive free radicals in skin, relieve peroxidation damage of tissues or cells, enhance skin barrier, and strengthen skin structure to resist skin aging relaxation.

2) The inventive anti-aging efficacy liposome wraps the selected efficacy components and is compounded into the face cream composition, so that the transdermal delivery efficiency of the face cream composition can be enhanced, the residence time of the efficacy components in the skin can be prolonged, the efficacy components can be slowly released, and the utilization rate of the efficacy components can be increased.

Drawings

FIG. 1 is a graph showing the rate of change of wrinkles at the outer corners of the skin after 56 days using example 1;

FIG. 2 is a graph showing the change in skin collagen density test values after 56 days using example 1;

FIG. 3 is a graph showing the change rate of wrinkles at the external skin corners after 14 to 56 days using example 1 and comparative examples 1 to 15.

Detailed Description

The invention discloses a face cream composition containing anti-aging efficacy liposome. The main wrinkle-removing ingredients of the cream composition include: hexapeptide-11, dunaliella salina extract, leucasian willow extract, gynostemma pentaphyllum extract, through preferred combination and efficacy test, the most preferred composition ratio is found, and the synergistic anti-aging and wrinkle removing effects are obtained through liposome encapsulation.

The hexapeptide-11 is produced by controlling the metabolism and fermentation conditions of microorganisms through a biological fermentation method, and the amino acid sequence is optimized through genetic engineering, so that the hexapeptide-11 has high recognition degree and high purity, and has the main effects of promoting the synthesis of collagen, strengthening the skin structure, improving the skin elasticity and having better anti-aging and tightening effects.

Dunaliella salina extract: the Dunaliella has high content of beta-carotene, lipid, protein and the like, has positive effects on body health and is important for cell health, can resist oxidative damage, and has a protective effect on cell components. Is a potent free radical, a quencher of singlet oxygen and a lipid antioxidant.

The extract of Epilobium freundum is a 100% natural, pure and micro-ecologically friendly organic active, which is extracted from mountain plants grown on an alpine with an altitude of 2500 m. The product can be used as an organic prebiotic with biological activity, and can strengthen the defending ability of skin and resist the damage of the environment to the skin.

Gynostemma pentaphylla extract: the main lower component of the gynostemma pentaphylla extract is gynostemma pentaphylla saponin, and experiments prove that the gynostemma pentaphylla extract can prolong the cell reproduction algebra of organisms and prolong the cell life; the gynostemma pentaphylla extract can be used for favorably strengthening the activity of superoxide dismutase and reducing the formation of lipid peroxide in the body, prevents the inactivation of intracellular protein molecules, prevents or stops peroxidation of lipid in the body to a certain extent, and achieves the anti-aging purpose.

The invention is illustrated by the following examples which are given for further illustration of the invention and are not intended to limit the scope of the invention. Some insubstantial modifications and adaptations of the invention by others are within the scope of the invention.

The following percentages (%) are mass percentages unless otherwise indicated. All raw material components of the invention are commercial products.

Examples 1 to 3

A facial cream composition containing anti-aging liposome is prepared into anti-aging facial cream, and the raw material components and contents are shown in the following table 1.

TABLE 1 raw material composition ratio (unit: mass%) of examples 1-3

The preparation process of the cream composition containing the anti-aging efficacy liposome of the above embodiment 1 comprises the following steps:

1) Preparation of anti-aging efficacy liposome a: weighing 400mg of hexapeptide-11, 800mg of dunaliella salina extract, 800mg of Leisha fumarmorata extract and 800mg of gynostemma pentaphylla extract, and dissolving in phosphate buffer solution with pH=6.8 by ultrasonic; 1000mg of phospholipid and 200mg of cholesterol are weighed and dissolved in diethyl ether by ultrasonic dissolution; pouring the phosphate buffer solution into diethyl ether, homogenizing at 15000r/min for 5min, and removing the organic solvent at room temperature; adding 2% mannitol, performing ultrasonic treatment on the mixed solution to obtain emulsion, filtering with a 0.45 μm filter membrane, and lyophilizing the filtrate with a lyophilizer for 24 hr to obtain anti-aging liposome a coated with effective components;

2) Dissolving a thickening agent with deionized water, and uniformly stirring and dispersing;

3) Adding a humectant into the mixed solution in the step 2), stirring, heating to 75 ℃, and preserving heat and stirring for 20 minutes to obtain a water phase material;

4) Dissolving an emollient and an emulsifier with deionized water, stirring and dispersing uniformly, and heating to 75 ℃ until the emollient and the emulsifier are completely dissolved to obtain an oil phase material;

5) Slowly adding the oil phase raw material into the water phase material in a homogeneous state of 4000r/min, continuously homogenizing for 10min, and then adding the pH value regulator, the filler and the preservative;

6) Stirring and cooling the mixed solution in the step 5) to 45 ℃, adding the anti-aging liposome a and the daily essence, and homogenizing for 8min at 2000 r/min;

7) After homogenization, stirring at the speed of 250r/min, and cooling to 35 ℃ to obtain the cream composition containing the anti-aging liposome.

The preparation process of the anti-aging facial cream composition of the above example 2 comprises the following steps:

1) Preparation of anti-aging efficacy liposome b: 643mg of hexapeptide-11, 1286mg of dunaliella salina extract, 1286mg of salix volvulus extract, 1286mg of gynostemma pentaphylla extract are weighed and dissolved in phosphate buffer solution with pH=6.8 by ultrasonic; weighing 2000mg of phospholipid and 1000mg of cholesterol, dissolving in a proper amount of dichloromethane, and performing ultrasonic dissolution; pouring the phosphate buffer solution into dichloromethane, homogenizing at 20000r/min for 8min, and removing the organic solvent at room temperature; adding 2.5% mannitol, ultrasonic treating the mixed solution to obtain emulsion, filtering with 0.45 μm filter membrane, lyophilizing the filtrate with a lyophilizing machine for 48 hr to obtain liposome b coated with effective components;

3) Adding a humectant into the mixed solution in the step 2), stirring, heating to 80 ℃, and preserving heat and stirring for 30 minutes to obtain a water phase material;

4) Dissolving an emollient and an emulsifier with deionized water, stirring and dispersing uniformly, and heating to 80 ℃ until the emollient and the emulsifier are completely dissolved to obtain an oil phase material;

5) Slowly adding the oil phase raw material into the water phase material in a homogeneous state of 5000r/min, continuously homogenizing for 15min, and then adding the pH value regulator, the filler and the preservative;

6) Stirring and cooling the mixed solution in the step 5) to 50 ℃, adding the anti-aging liposome b and the daily essence, and homogenizing for 10min at 3000 r/min;

7) After homogenization, stirring and cooling to 40 ℃ at the speed of 300 revolutions per minute, and obtaining the cream composition containing the anti-aging efficacy liposome.

The preparation process of the anti-aging facial cream composition of the above example 3 comprises the following steps:

1) Preparation of anti-aging efficacy liposome c: weighing 142mg of hexapeptide-11, 284mg of dunaliella salina extract, 284mg of Fullerene salix extract and 284mg of gynostemma pentaphylla extract, and dissolving in phosphate buffer solution with pH=6.8 by ultrasonic; weighing 800mg of phospholipid and 100mg of cholesterol, dissolving in a proper amount of organic solvent by ultrasonic waves; pouring the phosphate buffer solution into the organic solution, homogenizing at 10000r/min for 3min, and removing the organic solvent at room temperature; adding 1.5% mannitol, ultrasonically treating the mixed solution into emulsion, filtering with 0.45 μm filter membrane, and lyophilizing the filtrate with a lyophilizing machine for 12 hr to obtain liposome c coated with effective components;

3) Adding a humectant into the mixed solution in the step 2), stirring, heating to 70 ℃, and preserving heat and stirring for 15 minutes to obtain a water phase material;

4) Dissolving an emollient and an emulsifier with deionized water, stirring and dispersing uniformly, and heating to 70 ℃ until the emollient and the emulsifier are completely dissolved to obtain an oil phase material;

5) Slowly adding the oil phase raw material into the water phase material in a homogeneous state of 3000r/min, continuously homogenizing for 8min, and then adding the pH value regulator, the filler and the preservative;

6) Stirring and cooling the mixed solution in the step 5) to 40 ℃, adding the anti-aging liposome c and the daily essence, and homogenizing for 5min at 1500 r/min;

7) After homogenization, stirring and cooling to 30 ℃ at the speed of 200r/min, thus obtaining the facial cream composition containing the anti-aging efficacy liposome.

Effect verification test example

1. Safety test

Test sample: example 1;

the testing method comprises the following steps: and testing the security by adopting a third party detection mechanism. The selected area is not more than 50mm ² A suitable patch device having a depth of about 1mm is provided by adding about 0.02 to about 0.025ml (g) of a subject to the patch device by a closed patch test method. The patch tester is attached to the forearm of a subject, the test object is removed after 24 hours, skin reactions are observed after 0.5 hour, 24 hours and 48 hours respectively, and the results are recorded according to the skin reaction grading standard in cosmetic safety technical regulations 2015.

TABLE 2 Patch test results

Remarks: skin reaction grading criterion

Level 0: a negative reaction;

stage 1: suspicious reactions; only weak erythema;

2 stages: weak positive response (erythema response); erythema, infiltration, edema, and possibly papules;

3 stages: strong positive response (herpes response); erythema, infiltration, edema, papules, herpes; the reaction may be beyond the test zone;

4 stages: extremely strong reactions (fusogenic herpetic reactions); obvious erythema, severe infiltration, edema, blepharospermia, and response beyond the test area.

From table 2 above, the prepared cream showed no irritation and was safe.

2. Stability test

Test sample: example 1;

the testing method comprises the following steps: internal control standard, the appearance color, viscosity, pH for three months was observed.

TABLE 3 stability investigation results

Time

45℃

40℃

37℃

25℃

5℃

-15℃

CYCLE

Illumination of

1W

√

2W

√

3W

√

4W

√

2M

√

3M

√

As shown in the table 3, the prepared face cream has no obvious change in color, viscosity and pH within three months under the conditions of high and low temperature or illumination, which proves that the face cream has better stability.

3. Evaluation of anti-aging Effect of face cream

Test sample: the experimental group is example 1, and the control group is a basic cream without the liposome of the efficacy component.

The testing method comprises the following steps: after daily face cleaning, a proper amount of test group samples are smeared on one side face randomly, and a control group sample is smeared on the other side. The sunscreen product is applied to the whole face daily in the morning.

The results were tested in the following 4 time periods, respectively:

before the sample (D0), after 14 days of the sample (D14), after 28 days of the sample (D28), and after 56 days of the sample (D56). The test is performed in a room at 20-22 c with a relative humidity of 40-60% and the subject must now be conditioned for 15 minutes in the same environment.

The detection items are as follows:

1) Primos is used for facial image acquisition and skin wrinkle analysis;

2) The Dermalab combo ultrasonic probe (frequency 20 MHz) was used to evaluate skin collagen density, and the larger the test value, the greater the skin collagen density.

Test results:

as shown in fig. 1-2, tables 4-5 show the clinical efficacy test results of example 1, and the analysis test performed on the target site of the use test can result in a significant reduction of 12.24% in skin external corner wrinkles after 56 days on one side of the use test group, while the reduction of only 2.45% in the control group; in addition, in the test experiment of the collagen density, the skin collagen density test value of the experimental group is improved from 32.6 to 42.7, the change rate is about 31%, and the control group is only improved by 4.8%, so that the prepared anti-aging facial cream can effectively reduce the occurrence of facial wrinkles and promote the synthesis of the skin collagen density, and has a good anti-aging effect.

TABLE 4 rate of change of wrinkles at the external skin corners

Time	After 14 days of use	After 28 days of use	After using for 56 days
				Experimental group	-4.63％	-8.19％	-12.24％
Control group	-1.42％	-1.98％	-2.45％

TABLE 5 skin collagen Density test values

Time	Day 0 of use	After 14 days of use	After 28 days of use	After using for 56 days
					Experimental group	32.6	38.5	40.2	42.7
Control group	32.9	33.7	34.1	34.5

4. Synergistic test of anti-aging composition

A facial cream composition containing antiaging effect is prepared into facial cream, and the content of the raw material components of the control example is shown in the following tables 6-7.

TABLE 6 anti-aging face cream composition proportion Table (unit: mass%) of comparative examples 1 to 7

TABLE 7 anti-aging face cream composition proportion Table (unit: mass%) of comparative examples 8-15

The preparation process of the anti-aging face cream comprises the following steps:

1) Dissolving a thickening agent with deionized water, and uniformly stirring and dispersing;

2) Adding a humectant into the mixed solution in the step 1), stirring, heating to 75 ℃, and preserving heat and stirring for 20 minutes to obtain a water phase material;

3) Dissolving an emollient and an emulsifier with deionized water, stirring and dispersing uniformly, and heating to 75 ℃ until the emollient and the emulsifier are completely dissolved to obtain an oil phase material;

4) Slowly adding the oil phase raw material into the water phase material in a homogeneous state of 4000r/min, continuously homogenizing for 10min, and then adding the pH value regulator, the filler and the preservative;

5) Stirring and cooling the mixed solution in the step 4) to 45 ℃, adding the corresponding parts of anti-aging functional components and essence, and homogenizing for 8min at 2000 r/min;

6) After homogenization, stirring at the speed of 250r/min, and cooling to 35 ℃ to obtain the cream composition containing the anti-aging liposome.

The effect of the anti-aging composition synergy test example and the control example was verified (wrinkle removal effect evaluation), and the test procedure and results are as follows:

1. the tester: 160 healthy females (25-45 years old) are divided into 16 groups of 10 individuals each; the same formulation was used for each group.

2. The method comprises the following steps: after daily face cleaning, a proper amount of test group samples are smeared on one side face randomly, and a control group sample is smeared on the other side. The sunscreen product is applied to the whole face daily in the morning. The results were tested in the following 4 time periods, respectively: before the sample (D0), after 14 days of the sample (D14), after 28 days of the sample (D28), and after 56 days of the sample (D56). The test is performed in a room at 20-22 c with a relative humidity of 40-60% and the subject must now be conditioned for 15 minutes in the same environment.

3. Test instrument: primos is used for facial image acquisition and skin wrinkle analysis.

4. The test results are shown in table 7 below.

Table 7 test set effect

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The results in table 7 and fig. 3 show that the wrinkle removing ability: example 1> comparative example 15> comparative examples 11-14> comparative examples 5-10> comparative examples 1-4, demonstrate that the selected functional ingredients of the present invention can effectively reduce skin external eye corner wrinkles by 8.13% when used in combination at the same time, and have a better anti-aging effect than the use of a single component.

In addition, when the liposome is used for coating the active ingredient, the capability of reducing wrinkles of the external corners of the skin reaches 12.24%, and the liposome is used for coating the selected active ingredient, so that the transdermal delivery efficiency can be enhanced, the residence time of the active ingredient in the skin can be prolonged, the active ingredient can be slowly released, and the utilization rate of the active ingredient can be increased.

In conclusion, the facial cream composition provided by the invention has a remarkable anti-aging effect, can effectively improve the collagen density of skin and improve the ability of skin wrinkles, can delay the arrival of skin aging when the facial cream prepared by the composition is used for a long time, and can also be more youthful and vigor in the same age.

The present invention is not limited to the preferred embodiments, but can be modified, equivalent, and modified in any way without departing from the technical scope of the present invention.

Claims

1. A facial cream composition containing liposome with anti-aging effect is characterized in that,

the cream composition consists of the following components in percentage by weight:

85-99.9% of cosmetic auxiliary material matrix;

the anti-aging efficacy liposome comprises the following main components in percentage by mass based on the total weight of the composition:

2. A cream composition comprising liposomes having anti-aging efficacy according to claim 1,

the cosmetic auxiliary material matrix comprises the following components in percentage by weight:

3. A cream composition comprising liposomes having anti-aging efficacy according to claim 1,

4. A cream composition comprising liposomes having anti-aging efficacy according to claim 1,

the preparation method of the anti-aging efficacy liposome comprises the following steps:

2) Weighing phospholipid and cholesterol according to the mass ratio of (1-8): 1 dissolving in an appropriate amount of organic solvent by ultrasonic dissolution;

4) Adding mannitol, ultrasonically processing the mixed solution in the step 3) into emulsion, filtering with a filter membrane with the diameter of 0.45 mu m, and freeze-drying the filtrate for 12-48 hours by a freeze dryer to obtain the anti-aging liposome coated with the functional components.

5. A cream composition comprising liposomes having anti-aging efficacy according to claim 4,

the phospholipid is one or more selected from lecithin, cephalin, dipalmitoyl phospholipid and hydrogenated soybean phospholipid;

the organic solvent is selected from one or more of dichloromethane, diethyl ether, ethyl acetate, chloroform and acetone;

the particle size of the liposome is 50-200nm.

6. A cream composition containing anti-aging efficacy liposomes as claimed in claim 2, wherein:

the humectant is selected from: one or more of glycerol, butanediol, sorbitol, xylitol, panthenol, trehalose, sodium hyaluronate acetylation, and phytosterol fatty alcohols;

the emollient is selected from: one or more of isohexadecane, isopropyl isostearate, caprylic/capric triglyceride, butter fruit, silicone oil;

the pH regulator is one or more of lactic acid, arginine and sodium hydroxide.

7. A method for preparing a cream composition containing liposomes with anti-aging efficacy as claimed in any one of claims 3 to 6, characterized in that:

the method comprises the following steps:

8. A cosmetic product characterized by:

the cosmetic comprises the facial cream composition with anti-aging liposome prepared by the preparation method of claim 7;

the cosmetic is in the form of solvent dispersion or suspension, or in the form of emulsified particles, or in the form of polymer packages.