CN115282082A - Oil skin anti-free radical composition and application thereof - Google Patents
Oil skin anti-free radical composition and application thereof Download PDFInfo
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- CN115282082A CN115282082A CN202210800607.2A CN202210800607A CN115282082A CN 115282082 A CN115282082 A CN 115282082A CN 202210800607 A CN202210800607 A CN 202210800607A CN 115282082 A CN115282082 A CN 115282082A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Gerontology & Geriatric Medicine (AREA)
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Abstract
The invention relates to the field of A61K8/00, in particular to a composition for resisting free radicals of oil skins and application thereof. The invention adopts specific vitamin C derivatives, antioxidant amino acids and antioxidants, and through the synergistic compounding effect of the raw materials, the provided oil skin anti-free radical composition has both the radical characteristics of lipophilic free radicals and hydrophilic free radicals, and can effectively reduce the free radicals of the lipophilic and hydrophilic groups aiming at the characteristics of oily skin, thereby achieving the purpose of resisting oxidation of the oil skin.
Description
Technical Field
The invention relates to the field of A61K8/00, in particular to an oil skin anti-free radical composition and application thereof.
Background
Free radicals are atoms or molecules whose outermost orbitals contain unpaired electrons, which have very reactive chemical properties and are susceptible to reaction. The active chemical nature of free radicals makes them very susceptible to the destruction of molecules in the skin, such as collagen, hyaluronic acid, cell membranes, etc., which in turn may cause a series of skin problems or accelerate skin aging. The free radicals may capture electrons of other atoms or molecules, and the atoms or molecules capturing electrons may also become free radicals, so that the electrons of other molecules may be captured, and a chain reaction may be formed to a certain extent, so that the skin may be damaged very widely.
The damage caused by free radicals to the skin can occur both intracellularly and extracellularly, even on the cell membrane. The aging process of organisms is the result of accumulation of free radicals continuously generated by tissue cells of the organisms, and the free radicals can cause DNA damage to cause mutation and induce tumor formation. Free radicals are intermediate products of normal metabolism, have strong reaction capability, and can oxidize various substances in cells to damage biological membranes. But also cross-link macromolecules such as proteins and nucleic acids, and influence the normal functions of the proteins and nucleic acids.
Chinese patent CN113101238A discloses an anti-free radical composition, a preparation method and an application thereof, biological carbohydrate gum, sodium hyaluronate, carbohydrate isomer, sodium polyglutamate and the like are taken as raw materials, and the scavenging effect of the composition on free radicals is improved by adopting small-molecule antioxidant components. However, lipophilic free radicals and hydrophilic free radicals are generated in the process of generating free radicals, and due to the characteristics of the hydrophilic and lipophilic radicals, the hydrophilic antioxidant components have little effect on the lipophilic free radicals, and the products for resisting free radicals in the market at present mainly aim at the hydrophilic free radicals to achieve the purpose of resisting oxidation, but have limitation on the oil skin, so that special lipophilic antioxidant components are needed to aim at the lipophilic free radicals to achieve good free radical scavenging effect and antioxidant effect.
Disclosure of Invention
In order to solve the above problems, the present invention provides an anti-free radical composition for oil skin, which is prepared from at least the following raw materials: vitamin C derivative, antioxidant amino acid, and antioxidant mixture.
As a preferable technical scheme, the vitamin C derivative is at least one selected from vitamin C phosphate, ascorbyl palmitate and ascorbyl glucoside. Preferably, the vitamin C derivative is ascorbyl palmitate; preferably, the ascorbyl palmitate is ascorbyl tetraisopalmitate. The ascorbyl tetraisopalmitate is from Shanghai Keqin science and technology, inc.
As a preferable technical scheme, the antioxidant amino acid is at least one of ergothioneine and conopeptide. Preferably, the antioxidant amino acid is ergothioneine; the ergothioneine is from Shanghai Keqin science and technology, inc.
Based on the system, the specific vitamin C derivative, the antioxidant amino acid and the antioxidant are adopted, and the synergistic compounding effect of the raw materials ensures that the provided oil skin anti-free radical composition gives consideration to the radical characteristics of lipophilic free radicals and hydrophilic free radicals, can effectively reduce the free radicals of the lipophilic and hydrophilic groups aiming at the characteristics of oily skin, and achieves the purpose of resisting oxidation of the oil skin.
Based on the system, the ascorbyl tetraisopalmitate oil adopted in the invention is oil-soluble, the ascorbyl tetraisopalmitate does not have antioxidant property, but the ascorbyl tetraisopalmitate can rapidly enter cells and is gradually decomposed into ascorbyl triisopalmitate, ascorbyl diisopalmitate and ascorbic acid, and the ascorbyl triisopalmitate has lipophilic property and antioxidant property, so that the system has targeted antioxidant effect on lipophilic radicals, and meanwhile, the water-soluble ergothione can be accumulated in various cells such as keratinocytes, melanocytes and the like through a transport protein OCTN1, EGT can be accumulated in the cells, and the comprehensive free radical removing effect and the excellent antioxidant effect are cooperatively realized.
As a preferred solution, the antioxidant mixture comprises at least ascorbyl tetraisopalmitate, tocopherol (vitamin E); preferably, the antioxidant mixture is SMARTVECTOR, which is derived from BASF. According to the composition provided by the invention, an antioxidant mixture SMARTVECTOR is introduced, wherein the SMARTVECTOR intelligently wraps ascorbyl tetraisopalmitate and tocopherol (vitamin E), active ingredients of the ascorbyl tetraisopalmitate and the tocopherol (vitamin E) are released under ultraviolet irradiation according to the change of illumination intensity, and free radicals generated by the ultraviolet irradiation are neutralized, so that the effect of the anti-free radical effect of the composition is further improved.
On the other hand, the invention provides application of the composition for resisting free radicals in oil skin, and the composition is applied to preparation of antioxidant essence water, essence liquid, emulsion and cream products.
As a preferable technical scheme, the composition is applied to the preparation of essence and at least comprises the following steps:
(1) Adding deionized water, a solvent and a thickening agent into a stirring pot, stirring and heating, homogenizing and stirring, and then cooling;
(2) Cooling to 30-35 deg.C under stirring, adding the composition and antiseptic, homogenizing, and stirring;
(3) And (5) cooling to normal temperature, sampling, inspecting, and discharging qualified product to obtain the antioxidant essence.
Preferably, the heating temperature in the step (1) is 80-85 ℃, and the time for homogenizing and stirring in the step (1) is 2-6min.
Preferably, the rotation speed of the homogenizing and stirring in the step (1) and the step (2) is 2200 to 2500r/min.
Preferably, the time for homogenizing and stirring in the step (2) is 3-4h.
Preferably, the content of the vitamin C derivative added in the composition in the step (3) is 0.01-20wt% based on the total mass of the essence; the addition content of antioxidant amino acid is 0.01-20wt%; the antioxidant mixture is added in an amount of 0.01-10wt%.
As a preferred technical scheme, the composition is applied to the preparation of the face cream and at least comprises the following steps:
s1, adding deionized water into an emulsifying pot, adding a thickening agent, mixing and stirring, and homogenizing for 3-10 min; heating, adding a surfactant, a preservative and a solvent, and stirring until the water phase is completely and uniformly dissolved;
s2, putting the grease into an oil phase pot, heating and stirring until the oil phase is dissolved and transparent;
and S3, adding the oil phase into the water phase, adding the composition, stirring, homogenizing, cooling and discharging to obtain the antioxidant cream. As a preferable technical scheme, the mixing and stirring time in the step (1) is 10-30min; the mixing and stirring speed in the step (1) is 3000-6000 r/min.
As a preferable technical scheme, the heating temperature in the step (2) is 65-75 ℃; the stirring speed is 200-500 r/min.
Preferably, the content of the vitamin C derivative in the composition in the step S3 is 0.01-20wt% based on the total mass of the face cream; the addition content of antioxidant amino acid is 0.01-20wt%; the content of the antioxidant mixture is 0.01-10wt%.
Has the advantages that:
1. the invention provides an oil skin anti-free radical composition, which adopts specific vitamin C derivatives, antioxidant amino acid and antioxidant, and the synergistic compounding effect of the raw materials ensures that the provided oil skin anti-free radical composition gives consideration to the radical characteristics of lipophilic free radicals and hydrophilic free radicals, can effectively reduce the free radicals of the lipophilic and hydrophilic groups aiming at the characteristics of oily skin, and achieves the purpose of resisting oxygen of oil skin.
2. Based on the system, the ascorbic acid tetraisopalmitate is adopted to cooperate with the ergothioneine, so that the comprehensive free radical removal effect and the excellent antioxidant effect are realized.
3. According to the composition provided by the invention, an antioxidant mixture SMARTVECTOR is introduced, wherein the SMARTVECTOR intelligently wraps ascorbyl tetraisopalmitate and tocopherol (vitamin E), active ingredients of the ascorbyl tetraisopalmitate and the tocopherol (vitamin E) are released under ultraviolet irradiation according to the change of illumination intensity, and free radicals generated by the ultraviolet irradiation are neutralized, so that the effect of the anti-free radical effect of the composition is further improved.
4. The composition provided by the invention is effectively applied to the preparation of antioxidant essence water, essence liquid, emulsion and cream products, so that the prepared antioxidant product has an excellent antioxidant effect.
Drawings
FIG. 1 is a graph showing the skin gloss values before and after 28 days using the essence prepared in example 1;
FIG. 2 is a graph of ITA value of skin type angle before and after 28 days using the essence prepared in example 1;
FIG. 3 is a graph showing a comparison between the skin conditions of the test subject No. 4 before and after 28 days using the essence prepared in example 1; FIG. 4 is a graph showing a comparison between the skin condition of the subject 9 before and after 28 days using the essence prepared in example 1;
fig. 5 is a 3D model of the skin of the right canthus before and after 28 days of the serum prepared in example 1 for subject No. 4.
Fig. 6 is a 3D model of the skin of the right canthus before and after 28 days using the essence prepared in example 1 for the subject No. 9.
Detailed Description
Example 1
Embodiment 1 of the present invention provides an anti-free radical composition for oil skin, which is prepared from the following raw materials: vitamin C derivative, antioxidant amino acid, and antioxidant mixture.
The vitamin C derivative is ascorbyl palmitate; the ascorbyl palmitate is ascorbyl tetraisopalmitate. The ascorbyl tetraisopalmitate is from Shanghai Keqin science and technology, inc.
The antioxidant amino acid is ergothioneine; the ergothioneine is from Shanghai Keqin science and technology, inc.
The antioxidant mixture is SMARTVECTOR, which is derived from BASF.
In another aspect, embodiment 1 of the present invention provides an application of a composition for skin care against free radicals, which is applied to the preparation of an antioxidant essence.
The composition is applied to the preparation of the antioxidant essence, and comprises the following steps:
(1) Adding deionized water, a solvent and a thickening agent into a stirring pot, stirring and heating, homogenizing and stirring, and then cooling;
(2) Cooling to 30 deg.C under stirring, adding the composition and antiseptic, homogenizing, and stirring;
(3) Cooling to 25 deg.C, sampling, inspecting, and discharging to obtain antioxidant essence.
The heating temperature in the step (1) is 80 ℃, and the homogenizing and stirring time in the step (1) is 5min.
The rotation speed of homogenizing and stirring in the step (1) and the step (2) is 2500r/min.
The time for homogenizing and stirring in the step (2) is 4h.
Based on the total mass of the antioxidant essence, the addition content of the vitamin C derivative in the composition in the step (3) is 2wt%; the addition content of antioxidant amino acid is 2wt%; the addition content of the antioxidant mixture is 1wt%;
the dosage of the antioxidant essence is shown in the following table 1.
TABLE 1
| Raw materials | Mass percent | Specific substance |
| Deionized water | The balance is supplemented to 100% | |
| Solvent(s) | 12％ | 1, 2-hexanediol |
| Thickening agent | 0.3％ | Xanthan gum |
| Preservative | 0.5％ | Ethyl hexyl glycerol |
Example 2
In one aspect, embodiment 2 of the present invention provides an anti-free radical composition for oil skin, which is prepared from the following raw materials: vitamin C derivative, antioxidant amino acid, and antioxidant mixture.
The vitamin C derivative is ascorbyl palmitate; the ascorbyl palmitate is ascorbyl tetraisopalmitate. The ascorbyl tetraisopalmitate was obtained from Shanghai Kenjin science and technology, inc.
The antioxidant amino acid is ergothioneine; the ergothioneine is from Shanghai Keqin science and technology, inc.
The antioxidant mixture is SMARTVECTOR, which is derived from BASF.
In another aspect, embodiment 2 of the present invention provides an application of a composition for skin care against free radicals, which is applied to the preparation of an antioxidant cream.
The composition is applied to the preparation of the antioxidant cream, and comprises the following steps:
s1, adding deionized water into an emulsifying pot, adding a thickening agent, mixing and stirring for 20 minutes at a stirring speed of 5000r/min, and homogenizing for 6 minutes; adding surfactant, antiseptic and solvent when the temperature in the emulsifying pot reaches 65 deg.C, maintaining at 300r/min, stirring and heating; when the temperature in the emulsifying pot reaches 75 ℃, stopping heating, and stirring until the water phase is completely and uniformly dissolved;
s2, putting the grease into an oil phase pot, stirring at 500r/min, heating at the same time, and keeping the constant temperature until the oil phase is dissolved and transparent when the temperature is raised to 70 ℃;
and S3, adding the oil phase into the water phase, adding the functional composition, stirring at 400r/min, adding the oil phase into the water phase, stirring at 4000r/min until the oil phase and the water phase are uniformly mixed, and homogenizing for 8min. Cooling to 50 deg.C, stirring at 5000r/min, and homogenizing for 6min until oil phase and water phase are mixed uniformly; stirring at the speed of 200r/min, cooling to room temperature, stopping stirring, and discharging.
The addition content of the vitamin C derivative in the composition in the step S3 is 2wt% based on the total mass of the antioxidant cream; the addition content of antioxidant amino acid is 2wt%; the addition content of the antioxidant mixture is 1wt%;
the dosage of the raw materials of the antioxidant cream is shown in the following table 2.
TABLE 2,
| Starting materials | Mass percent of | Specific material |
| Deionized water | The balance is supplemented to 100% | |
| Solvent(s) | 15％ | 1, 2-hexanediol |
| Thickening agent | 0.8％ | Xanthan gum |
| Preservative | 0.5％ | Ethyl hexyl glycerol |
| Surface active agent | 5％ | Cetearyl glucoside |
| Grease | 30％ | Butyrospermum parkii fruit resin |
Performance test method
1. Testing population: 31 Chinese healthy women of 30-60 years old
2. Test period and frequency of use: it is administered for 28 days, 1 time per day in the morning and evening
3. The using method comprises the following steps: after every day before and after the toner, an appropriate amount of the essence prepared in example 1 was uniformly applied to the face and massaged until absorption.
4. And (4) testing conclusion:
(1) After 28 days, the moisture content of the skin stratum corneum of the skin is remarkably increased (P is less than 0.001) by using the essence prepared in example 1, which shows that the test product has the effect of moisturizing for 28 days, and the improvement rate is 23.63%.
(2) After 28 days of using the essence prepared in example 1, the transepidermal water loss value of the skin was significantly reduced (P = 0.015), and the product was effective in reducing the water loss of the skin, indicating that the test product had the effect of 28-day repair.
(3) After 28 days, the skin red pigment value of the essence prepared in example 1 is obviously reduced (P = 0.001), and the face redness is improved, which indicates that the test product has a 28-day relieving effect, and the improvement rate is 10.89%.
(4) After 28 days, the skin gloss value is obviously improved (P is less than 0.001) by using the essence prepared in example 1, and the product enables the skin to become glossier, which shows that the test product has the effect of improving the skin gloss for 28 days, and the improvement rate is 32.30%, and the result is shown in figure 1.
(5) After 28 days using the essence prepared in example 1, the ITA ° value of the skin type angle of individual was significantly increased (P < 0.001), and the product had the effect of lightening the skin color, indicating that the test product had the effect of whitening for 28 days, with an improvement rate of 12.56%, as shown in fig. 2.
(6) Subject self-assessment questionnaire: after 28 days using the essence prepared in example 1, 93.55% of the subjects considered improvement of facial texture, 90.32% of the subjects considered improvement of facial wrinkles, 87.10% of the subjects considered lightening of facial wrinkles, 83.87% of the subjects considered reduction of facial wrinkles, 90.32% of the subjects considered firmer facial skin, and 96.77% of the subjects considered more elastic facial skin.
Claims (10)
1. The composition of the oil skin for resisting free radicals is characterized in that the preparation raw materials at least comprise the following components: vitamin C derivative, antioxidant amino acid, and antioxidant mixture.
2. The composition of claim 1, wherein the ascorbic acid derivative is at least one member selected from the group consisting of ascorbic acid phosphate, ascorbyl palmitate, and ascorbyl glucoside.
3. The composition of claim 2, wherein the vitamin C derivative is ascorbyl palmitate.
4. The composition of claim 1, wherein the antioxidant amino acid is at least one of ergothioneine and conopeptide.
5. The composition of claim 4, wherein the antioxidant amino acid is ergothioneine.
6. The composition according to claim 1, wherein said mixture of antioxidants comprises at least ascorbyl tetraisopalmitate, tocopherol.
7. The use of the composition for resisting free radicals in oil skin according to any one of claims 1 to 6 is characterized by being applied to the preparation of antioxidant essence water, essence liquid, emulsion and cream products.
8. The use of a composition according to claim 7, for the preparation of a serum, comprising at least the following steps:
(1) Adding deionized water, a solvent and a thickening agent into a stirring pot, stirring and heating, homogenizing and stirring, and then cooling;
(2) Cooling to 30-35 deg.C under stirring, adding the composition and antiseptic, homogenizing, and stirring;
(3) And (5) cooling to normal temperature, sampling, inspecting, and discharging qualified product to obtain the antioxidant essence.
9. Use of a composition according to claim 7, for the preparation of a cream, comprising at least the following steps:
s1, adding deionized water into an emulsifying pot, adding a thickening agent, mixing and stirring, and homogenizing for 3-10 min; heating, adding a surfactant, a preservative and a solvent, and stirring until the water phase is completely and uniformly dissolved;
s2, putting the grease into an oil phase pot, heating and stirring until the oil phase is dissolved and transparent;
and S3, adding the oil phase into the water phase, adding the composition, stirring, homogenizing, cooling and discharging to obtain the antioxidant cream.
10. The use of the composition according to claim 9, wherein the mixing and stirring time in step S1 is 10-30min; the mixing and stirring speed in the step (1) is 3000-6000 r/min.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210800607.2A CN115282082A (en) | 2022-07-06 | 2022-07-06 | Oil skin anti-free radical composition and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210800607.2A CN115282082A (en) | 2022-07-06 | 2022-07-06 | Oil skin anti-free radical composition and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1636547A (en) * | 2003-08-21 | 2005-07-13 | 纽创基纳有限公司 | Stabilized compositions containing an oxygen-labile active agent |
| CN110448495A (en) * | 2019-09-09 | 2019-11-15 | 上海新高姿化妆品有限公司 | A kind of cosmetic composition with collaboration antioxidant effect |
| CN112870138A (en) * | 2021-01-26 | 2021-06-01 | 广州华厦生物制药有限公司 | Vegetable protein repair milk |
| CN113893203A (en) * | 2021-11-23 | 2022-01-07 | 湖北省麦诗特生物科技有限公司 | Face cream composition containing anti-aging liposome and preparation method and application thereof |
-
2022
- 2022-07-06 CN CN202210800607.2A patent/CN115282082A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1636547A (en) * | 2003-08-21 | 2005-07-13 | 纽创基纳有限公司 | Stabilized compositions containing an oxygen-labile active agent |
| CN110448495A (en) * | 2019-09-09 | 2019-11-15 | 上海新高姿化妆品有限公司 | A kind of cosmetic composition with collaboration antioxidant effect |
| CN112870138A (en) * | 2021-01-26 | 2021-06-01 | 广州华厦生物制药有限公司 | Vegetable protein repair milk |
| CN113893203A (en) * | 2021-11-23 | 2022-01-07 | 湖北省麦诗特生物科技有限公司 | Face cream composition containing anti-aging liposome and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 上海上水和肌生物科技有限公司: "《上水和肌极光亮彩焕颜乳》", pages 2 - 2, Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakan.html?prodId=1101521392219717632&gb=G> * |
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